Alessandro Guidotti - Publications

Affiliations: 
National Institute of Mental Health, Bethesda, MD, United States 

276 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Caradonna SG, Einhorn NR, Saudagar V, Khalil H, Petty GH, Lihagen A, LeFloch C, Lee FS, Akil H, Guidotti A, McEwen BS, Gatta E, Marrocco J. Corticosterone induces discrete epigenetic signatures in the dorsal and ventral hippocampus that depend upon sex and genotype: focus on methylated Nr3c1 gene. Translational Psychiatry. 12: 109. PMID 35296634 DOI: 10.1038/s41398-022-01864-7  0.652
2022 Matrisciano F, Locci V, Dong E, Nicoletti F, Guidotti A, Grayson DR. Altered Expression and in vivo Activity of mGlu5 variant a Receptors in the striatum of BTBR mice: Novel insights into the pathophysiology of adult idiopathic forms of autism spectrum disorders. Current Neuropharmacology. PMID 35139800 DOI: 10.2174/1567202619999220209112609  0.425
2021 Gatta E, Saudagar V, Drnevich J, Forrest MP, Auta J, Clark LV, Sershen H, Smith RC, Grayson DR, Davis JM, Guidotti A. Concordance of Immune-Related Markers in Lymphocytes and Prefrontal Cortex in Schizophrenia. Schizophrenia Bulletin Open. 2: sgab002. PMID 33585819 DOI: 10.1093/schizbullopen/sgab002  0.656
2021 Gatta E, Saudagar V, Auta J, Grayson DR, Guidotti A. Epigenetic landscape of stress surfeit disorders: Key role for DNA methylation dynamics. International Review of Neurobiology. 156: 127-183. PMID 33461662 DOI: 10.1016/bs.irn.2020.08.002  0.652
2020 Gatta E, Guidotti A, Saudagar V, Grayson DR, Aspesi D, Pandey SC, Pinna G. Epigenetic regulation of GABAergic neurotransmission and neurosteroid biosynthesis in alcohol use disorder. The International Journal of Neuropsychopharmacology. PMID 32968808 DOI: 10.1093/ijnp/pyaa073  0.664
2020 Auta J, Gatta E, Davis JM, Zhang H, Pandey SC, Guidotti A. Essential role for neuronal nitric oxide synthase in acute ethanol-induced motor impairment. Nitric Oxide : Biology and Chemistry. PMID 32278831 DOI: 10.1016/J.Niox.2020.04.003  0.675
2019 Gatta E, Grayson DR, Auta J, Saudagar V, Dong E, Chen Y, Krishnan HR, Drnevich J, Pandey SC, Guidotti A. Genome-wide methylation in alcohol use disorder subjects: implications for an epigenetic regulation of the cortico-limbic glucocorticoid receptors (NR3C1). Molecular Psychiatry. PMID 31239533 DOI: 10.1038/S41380-019-0449-6  0.679
2018 Matrisciano F, Dong E, Nicoletti F, Guidotti A. Epigenetic Alterations in Prenatal Stress Mice as an Endophenotype Model for Schizophrenia: Role of Metabotropic Glutamate 2/3 Receptors. Frontiers in Molecular Neuroscience. 11: 423. PMID 30564095 DOI: 10.3389/Fnmol.2018.00423  0.498
2018 Dong E, Locci V, Gatta E, Grayson DR, Guidotti A. N-Phthalyl-L-tryptophan (RG108), like clozapine (CLO), induces chromatin remodeling in brains of prenatally stressed mice. Molecular Pharmacology. PMID 30397000 DOI: 10.1124/Mol.118.113415  0.705
2018 Auta J, Gatta E, Davis JM, Pandey SC, Guidotti A. Potential role for histone deacetylation in chronic diazepam-induced downregulation of α1-GABA receptor subunit expression. Pharmacology Research & Perspectives. 6: e00416. PMID 29951207 DOI: 10.1002/Prp2.416  0.724
2017 Gatta E, Auta J, Gavin DP, Bhaumik DK, Grayson DR, Pandey SC, Guidotti A. Emerging role of one-carbon metabolism and DNA methylation enrichment on δ-containing GABAA receptor expression in the cerebellum of subjects with alcohol use disorders (AUD). The International Journal of Neuropsychopharmacology. PMID 29020412 DOI: 10.1093/Ijnp/Pyx075  0.789
2016 Gavin DP, Kusumo H, Zhang H, Guidotti A, Pandey SC. Role of Growth Arrest and DNA Damage-Inducible, Beta in Alcohol-Drinking Behaviors. Alcoholism, Clinical and Experimental Research. 40: 263-72. PMID 26842245 DOI: 10.1111/Acer.12965  0.655
2016 Matrisciano F, Panaccione I, Grayson DR, Nicoletti F, Guidotti A. Metabotropic Glutamate 2/3 Receptors and Epigenetic Modifications in Psychotic Disorders: A Review. Current Neuropharmacology. 14: 41-7. PMID 26813121 DOI: 10.2174/1570159X13666150713174242  0.423
2016 Matriscianoa F, Panaccione I, Grayson DR, Nicoletti F, Guidotti A. Metabotropic glutamate 2/3 receptors and epigenetic modifications in psychotic disorders: A review Current Neuropharmacology. 14: 41-47.  0.373
2015 Labouesse MA, Dong E, Grayson D, Guidotti A, Meyer U. Maternal immune activation induces GAD1 and GAD2 promoter remodeling in the offspring prefrontal cortex. Epigenetics. 0. PMID 26575259 DOI: 10.1080/15592294.2015.1114202  0.353
2015 Gavin DP, Kusumo H, Sharma RP, Guizzetti M, Guidotti A, Pandey SC. Gadd45b and N-methyl-D-aspartate induced DNA demethylation in postmitotic neurons. Epigenomics. 7: 567-79. PMID 26111030 DOI: 10.2217/Epi.15.12  0.674
2015 Dong E, Dzitoyeva SG, Matrisciano F, Tueting P, Grayson DR, Guidotti A. Brain-derived neurotrophic factor epigenetic modifications associated with schizophrenia-like phenotype induced by prenatal stress in mice. Biological Psychiatry. 77: 589-96. PMID 25444166 DOI: 10.1016/J.Biopsych.2014.08.012  0.301
2015 Gavin DP, Kusumo H, Sharma RP, Guizzetti M, Guidotti A, Pandey SC. Gadd45b and N-methyl-d-aspartate induced DNA demethylation in postmitotic neurons Epigenomics. 7: 567-579. DOI: 10.2217/epi.15.12  0.64
2014 Dong E, Ruzicka WB, Grayson DR, Guidotti A. DNA-methyltransferase1 (DNMT1) binding to CpG rich GABAergic and BDNF promoters is increased in the brain of schizophrenia and bipolar disorder patients. Schizophrenia Research. PMID 25476119 DOI: 10.1016/J.Schres.2014.10.030  0.364
2014 Guidotti A, Dong E, Tueting P, Grayson DR. Modeling the molecular epigenetic profile of psychosis in prenatally stressed mice. Progress in Molecular Biology and Translational Science. 128: 89-101. PMID 25410542 DOI: 10.1016/B978-0-12-800977-2.00004-8  0.309
2014 Guidotti A, Auta J, Davis JM, Dong E, Gavin DP, Grayson DR, Sharma RP, Smith RC, Tueting P, Zhubi A. Toward the identification of peripheral epigenetic biomarkers of schizophrenia. Journal of Neurogenetics. 28: 41-52. PMID 24702539 DOI: 10.3109/01677063.2014.892485  0.69
2014 Zhubi A, Chen Y, Dong E, Cook EH, Guidotti A, Grayson DR. Increased binding of MeCP2 to the GAD1 and RELN promoters may be mediated by an enrichment of 5-hmC in autism spectrum disorder (ASD) cerebellum. Translational Psychiatry. 4: e349. PMID 24448211 DOI: 10.1038/Tp.2013.123  0.317
2013 Auta J, Smith RC, Dong E, Tueting P, Sershen H, Boules S, Lajtha A, Davis J, Guidotti A. DNA-methylation gene network dysregulation in peripheral blood lymphocytes of schizophrenia patients. Schizophrenia Research. 150: 312-8. PMID 23938174 DOI: 10.1016/J.Schres.2013.07.030  0.322
2013 Chase KA, Gavin DP, Guidotti A, Sharma RP. Histone methylation at H3K9: evidence for a restrictive epigenome in schizophrenia. Schizophrenia Research. 149: 15-20. PMID 23815974 DOI: 10.1016/J.Schres.2013.06.021  0.679
2013 Guidotti A, Dong E, Gavin DP, Veldic M, Zhao W, Bhaumik DK, Pandey SC, Grayson DR. DNA methylation/demethylation network expression in psychotic patients with a history of alcohol abuse. Alcoholism, Clinical and Experimental Research. 37: 417-24. PMID 22958170 DOI: 10.1111/J.1530-0277.2012.01947.X  0.672
2013 Grayson DR, Guidotti A. The dynamics of DNA methylation in schizophrenia and related psychiatric disorders. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 138-66. PMID 22948975 DOI: 10.1038/Npp.2012.125  0.343
2013 Matrisciano F, Tueting P, Dalal I, Kadriu B, Grayson DR, Davis JM, Nicoletti F, Guidotti A. Epigenetic modifications of GABAergic interneurons are associated with the schizophrenia-like phenotype induced by prenatal stress in mice. Neuropharmacology. 68: 184-94. PMID 22564440 DOI: 10.1016/J.Neuropharm.2012.04.013  0.486
2012 Kadriu B, Guidotti A, Chen Y, Grayson DR. DNA methyltransferases1 (DNMT1) and 3a (DNMT3a) colocalize with GAD67-positive neurons in the GAD67-GFP mouse brain. The Journal of Comparative Neurology. 520: 1951-64. PMID 22134929 DOI: 10.1002/Cne.23020  0.357
2012 Matrisciano F, Tueting P, Maccari S, Nicoletti F, Guidotti A. Pharmacological activation of group-II metabotropic glutamate receptors corrects a schizophrenia-like phenotype induced by prenatal stress in mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 929-38. PMID 22089319 DOI: 10.1038/Npp.2011.274  0.502
2012 Gavin DP, Sharma RP, Chase KA, Matrisciano F, Dong E, Guidotti A. Growth arrest and DNA-damage-inducible, beta (GADD45b)-mediated DNA demethylation in major psychosis. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 531-42. PMID 22048458 DOI: 10.1038/Npp.2011.221  0.689
2012 Gavin DP, Sharma RP, Chase KA, Matrisciano F, Dong E, Guidotti A. Erratum: Growth Arrest and DNA-Damage-Inducible, Beta (GADD45b)-Mediated DNA Demethylation in Major Psychosis Neuropsychopharmacology. 37: 2173-2173. DOI: 10.1038/Npp.2012.55  0.618
2011 Kadriu B, Gocel J, Larson J, Guidotti A, Davis JM, Nambiar MP, Auta J. Absence of tolerance to the anticonvulsant and neuroprotective effects of imidazenil against DFP-induced seizure and neuronal damage. Neuropharmacology. 61: 1463-9. PMID 21903116 DOI: 10.1016/J.Neuropharm.2011.08.043  0.311
2011 Matrisciano F, Dong E, Gavin DP, Nicoletti F, Guidotti A. Activation of group II metabotropic glutamate receptors promotes DNA demethylation in the mouse brain. Molecular Pharmacology. 80: 174-82. PMID 21505039 DOI: 10.1124/Mol.110.070896  0.75
2011 Maloku E, Kadriu B, Zhubi A, Dong E, Pibiri F, Satta R, Guidotti A. Selective α4β2 nicotinic acetylcholine receptor agonists target epigenetic mechanisms in cortical GABAergic neurons. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 1366-74. PMID 21368748 DOI: 10.1038/Npp.2011.21  0.396
2011 Kadriu B, Guidotti A, Costa E, Davis JM, Auta J. Acute imidazenil treatment after the onset of DFP-induced seizure is more effective and longer lasting than midazolam at preventing seizure activity and brain neuropathology. Toxicological Sciences : An Official Journal of the Society of Toxicology. 120: 136-45. PMID 21097996 DOI: 10.1093/toxsci/kfq356  0.714
2011 Guidotti A, Auta J, Chen Y, Davis JM, Dong E, Gavin DP, Grayson DR, Matrisciano F, Pinna G, Satta R, Sharma RP, Tremolizzo L, Tueting P. Epigenetic GABAergic targets in schizophrenia and bipolar disorder. Neuropharmacology. 60: 1007-16. PMID 21074545 DOI: 10.1016/J.Neuropharm.2010.10.021  0.711
2011 Tueting P, Costa E, Guidotti A. Epigenetic animal models of GABAergic deficit in mental disorders Neuromethods. 59: 243-260. DOI: 10.1007/978-1-61779-157-4_11  0.651
2010 Dong E, Chen Y, Gavin DP, Grayson DR, Guidotti A. Valproate induces DNA demethylation in nuclear extracts from adult mouse brain. Epigenetics : Official Journal of the Dna Methylation Society. 5: 730-5. PMID 20716949 DOI: 10.4161/Epi.5.8.13053  0.67
2010 Tueting P, Davis JM, Veldic M, Pibiri F, Kadriu B, Guidotti A, Costa E. L-methionine decreases dendritic spine density in mouse frontal cortex. Neuroreport. 21: 543-8. PMID 20442623 DOI: 10.1097/WNR.0b013e3283373126  0.679
2010 Smith RC, Zhubi A, Maloku E, Sershen H, Lajtha A, Davis JM, Costa E, Guidotti A. Varenicline treatment decreases DNMT1 mRNA expression in lymphocytes of schizophrenic patients who are cigarette smokers. Schizophrenia Research. 119: 269-70. PMID 20335008 DOI: 10.1016/j.schres.2010.02.1064  0.675
2010 Auta J, Kadriu B, Giusti P, Costa E, Guidotti A. Anticonvulsant, anxiolytic, and non-sedating actions of imidazenil and other imidazo-benzodiazepine carboxamide derivatives. Pharmacology, Biochemistry, and Behavior. 95: 383-9. PMID 20227434 DOI: 10.1016/j.pbb.2010.02.016  0.722
2010 Maloku E, Covelo IR, Hanbauer I, Guidotti A, Kadriu B, Hu Q, Davis JM, Costa E. Lower number of cerebellar Purkinje neurons in psychosis is associated with reduced reelin expression. Proceedings of the National Academy of Sciences of the United States of America. 107: 4407-11. PMID 20150511 DOI: 10.1073/pnas.0914483107  0.699
2009 Dong E, Grayson DR, Guidotti A, Costa E. Antipsychotic subtypes can be characterized by differences in their ability to modify GABAergic promoter methylation. Epigenomics. 1: 201-11. PMID 22122643 DOI: 10.2217/Epi.09.2  0.706
2009 Zhubi A, Veldic M, Puri NV, Kadriu B, Caruncho H, Loza I, Sershen H, Lajtha A, Smith RC, Guidotti A, Davis JM, Costa E. An upregulation of DNA-methyltransferase 1 and 3a expressed in telencephalic GABAergic neurons of schizophrenia patients is also detected in peripheral blood lymphocytes. Schizophrenia Research. 111: 115-22. PMID 19386473 DOI: 10.1016/J.Schres.2009.03.020  0.7
2009 Pinna G, Costa E, Guidotti A. SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptake. Current Opinion in Pharmacology. 9: 24-30. PMID 19157982 DOI: 10.1016/j.coph.2008.12.006  0.728
2009 Kadriu B, Guidotti A, Costa E, Auta J. Imidazenil, a non-sedating anticonvulsant benzodiazepine, is more potent than diazepam in protecting against DFP-induced seizures and neuronal damage. Toxicology. 256: 164-74. PMID 19111886 DOI: 10.1016/j.tox.2008.11.021  0.714
2009 Guidotti A, Dong E, Kundakovic M, Satta R, Grayson DR, Costa E. Characterization of the action of antipsychotic subtypes on valproate-induced chromatin remodeling. Trends in Pharmacological Sciences. 30: 55-60. PMID 19110320 DOI: 10.1016/J.Tips.2008.10.010  0.731
2009 Costa E, Chen Y, Dong E, Grayson DR, Kundakovic M, Maloku E, Ruzicka W, Satta R, Veldic M, Zhubi A, Guidotti A. GABAergic promoter hypermethylation as a model to study the neurochemistry of schizophrenia vulnerability. Expert Review of Neurotherapeutics. 9: 87-98. PMID 19102671 DOI: 10.1586/14737175.9.1.87  0.709
2008 Satta R, Maloku E, Zhubi A, Pibiri F, Hajos M, Costa E, Guidotti A. Nicotine decreases DNA methyltransferase 1 expression and glutamic acid decarboxylase 67 promoter methylation in GABAergic interneurons. Proceedings of the National Academy of Sciences of the United States of America. 105: 16356-61. PMID 18852456 DOI: 10.1073/Pnas.0808699105  0.702
2008 Pibiri F, Kozikowski AP, Pinna G, Auta J, Kadriu B, Costa E, Guidotti A. The combination of huperzine A and imidazenil is an effective strategy to prevent diisopropyl fluorophosphate toxicity in mice. Proceedings of the National Academy of Sciences of the United States of America. 105: 14169-74. PMID 18784370 DOI: 10.1073/pnas.0807172105  0.711
2008 Dong E, Nelson M, Grayson DR, Costa E, Guidotti A. Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylation. Proceedings of the National Academy of Sciences of the United States of America. 105: 13614-9. PMID 18757738 DOI: 10.1073/Pnas.0805493105  0.683
2008 Auta J, Impagnatiello F, Kadriu B, Guidotti A, Costa E. Imidazenil: a low efficacy agonist at alpha1- but high efficacy at alpha5-GABAA receptors fail to show anticonvulsant cross tolerance to diazepam or zolpidem. Neuropharmacology. 55: 148-53. PMID 18555494 DOI: 10.1016/j.neuropharm.2008.05.002  0.71
2008 Pinna G, Agis-Balboa RC, Pibiri F, Nelson M, Guidotti A, Costa E. Neurosteroid biosynthesis regulates sexually dimorphic fear and aggressive behavior in mice. Neurochemical Research. 33: 1990-2007. PMID 18473173 DOI: 10.1007/s11064-008-9718-5  0.74
2008 Pibiri F, Nelson M, Guidotti A, Costa E, Pinna G. Decreased corticolimbic allopregnanolone expression during social isolation enhances contextual fear: A model relevant for posttraumatic stress disorder. Proceedings of the National Academy of Sciences of the United States of America. 105: 5567-72. PMID 18391192 DOI: 10.1073/pnas.0801853105  0.684
2008 Maloku E, Rivero-Covelo I, Hanbauer I, Guidotti A, Costa E. Aging in C57B/6 mice is accompanied by a decrease of Purkinje cells and changes in open field motor activity European Psychiatry. 23. DOI: 10.1016/J.Eurpsy.2008.01.1332  0.673
2008 Costa E, Chen Y, Dong E, Grayson DR, Guidotti A, Veldic M. Reelin downregulation as a prospective treatment target for GABAergic dysfunction in schizophrenia Reelin Glycoprotein: Structure, Biology and Roles in Health and Disease. 341-363. DOI: 10.1007/978-0-387-76761-1_23  0.658
2007 Agís-Balboa RC, Pinna G, Pibiri F, Kadriu B, Costa E, Guidotti A. Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice. Proceedings of the National Academy of Sciences of the United States of America. 104: 18736-41. PMID 18003893 DOI: 10.1073/pnas.0709419104  0.707
2007 Costa E, Dong E, Grayson DR, Guidotti A, Ruzicka W, Veldic M. Reviewing the role of DNA (cytosine-5) methyltransferase overexpression in the cortical GABAergic dysfunction associated with psychosis vulnerability. Epigenetics : Official Journal of the Dna Methylation Society. 2: 29-36. PMID 17965595 DOI: 10.4161/Epi.2.1.4063  0.73
2007 Dong E, Guidotti A, Grayson DR, Costa E. Histone hyperacetylation induces demethylation of reelin and 67-kDa glutamic acid decarboxylase promoters. Proceedings of the National Academy of Sciences of the United States of America. 104: 4676-81. PMID 17360583 DOI: 10.1073/pnas.0700529104  0.691
2007 Veldic M, Kadriu B, Maloku E, Agis-Balboa RC, Guidotti A, Davis JM, Costa E. Epigenetic mechanisms expressed in basal ganglia GABAergic neurons differentiate schizophrenia from bipolar disorder. Schizophrenia Research. 91: 51-61. PMID 17270400 DOI: 10.1016/j.schres.2006.11.029  0.709
2007 Ruzicka WB, Zhubi A, Veldic M, Grayson DR, Costa E, Guidotti A. Selective epigenetic alteration of layer I GABAergic neurons isolated from prefrontal cortex of schizophrenia patients using laser-assisted microdissection. Molecular Psychiatry. 12: 385-97. PMID 17264840 DOI: 10.1038/Sj.Mp.4001954  0.716
2007 Guidotti A, Ruzicka W, Grayson DR, Veldic M, Pinna G, Davis JM, Costa E. S-adenosyl methionine and DNA methyltransferase-1 mRNA overexpression in psychosis. Neuroreport. 18: 57-60. PMID 17259861 DOI: 10.1097/Wnr.0B013E32800Fefd7  0.712
2007 Maloku E, Satta R, Zhubi A, Veldic M, Kadriu B, Guidotti A, Costa E. Nicotinic cholinergic mechanisms in the regulation of brain DNA-methyltransferase 1 (DNMT1) expression European Psychiatry. 22: S88. DOI: 10.1016/J.Eurpsy.2007.01.1199  0.675
2006 Costa E, Dong E, Grayson DR, Ruzicka WB, Simonini MV, Veldic M, Guidotti A. Epigenetic targets in GABAergic neurons to treat schizophrenia. Advances in Pharmacology (San Diego, Calif.). 54: 95-117. PMID 17175812 DOI: 10.1016/S1054-3589(06)54005-0  0.72
2006 Sharma RP, Rosen C, Kartan S, Guidotti A, Costa E, Grayson DR, Chase K. Valproic acid and chromatin remodeling in schizophrenia and bipolar disorder: preliminary results from a clinical population. Schizophrenia Research. 88: 227-31. PMID 16996718 DOI: 10.1016/J.Schres.2006.07.015  0.703
2006 Agís-Balboa RC, Pinna G, Zhubi A, Maloku E, Veldic M, Costa E, Guidotti A. Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 103: 14602-7. PMID 16984997 DOI: 10.1073/pnas.0606544103  0.73
2006 Rasmusson AM, Pinna G, Paliwal P, Weisman D, Gottschalk C, Charney D, Krystal J, Guidotti A. Decreased cerebrospinal fluid allopregnanolone levels in women with posttraumatic stress disorder. Biological Psychiatry. 60: 704-13. PMID 16934764 DOI: 10.1016/J.Biopsych.2006.03.026  0.312
2006 Tueting P, Doueiri MS, Guidotti A, Davis JM, Costa E. Reelin down-regulation in mice and psychosis endophenotypes. Neuroscience and Biobehavioral Reviews. 30: 1065-77. PMID 16769115 DOI: 10.1016/j.neubiorev.2006.04.001  0.73
2006 Grayson DR, Chen Y, Costa E, Dong E, Guidotti A, Kundakovic M, Sharma RP. The human reelin gene: transcription factors (+), repressors (-) and the methylation switch (+/-) in schizophrenia. Pharmacology & Therapeutics. 111: 272-86. PMID 16574235 DOI: 10.1016/J.Pharmthera.2005.01.007  0.724
2006 Pinna G, Agis-Balboa RC, Zhubi A, Matsumoto K, Grayson DR, Costa E, Guidotti A. Imidazenil and diazepam increase locomotor activity in mice exposed to protracted social isolation. Proceedings of the National Academy of Sciences of the United States of America. 103: 4275-80. PMID 16537521 DOI: 10.1073/Pnas.0600329103  0.693
2006 Pinna G, Costa E, Guidotti A. Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake. Psychopharmacology. 186: 362-72. PMID 16432684 DOI: 10.1007/s00213-005-0213-2  0.717
2006 Simonini MV, Camargo LM, Dong E, Maloku E, Veldic M, Costa E, Guidotti A. The benzamide MS-275 is a potent, long-lasting brain region-selective inhibitor of histone deacetylases. Proceedings of the National Academy of Sciences of the United States of America. 103: 1587-92. PMID 16432198 DOI: 10.1073/pnas.0510341103  0.702
2006 Matsumoto K, Pinna G, Guidotti A, Costa E. Neuroendocrine consequences of social isolation Frontiers in Neuroendocrinology. 27: 134. DOI: 10.1016/J.Yfrne.2006.03.281  0.657
2005 Matsumoto K, Guidotti A, Costa E. [Stress and sleep/emotional disorder: possible involvement of neurosteroid allopregnanolone]. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 126: 107-12. PMID 16205012 DOI: JST.JSTAGE/fpj/126.107  0.657
2005 Dong E, Agis-Balboa RC, Simonini MV, Grayson DR, Costa E, Guidotti A. Reelin and glutamic acid decarboxylase67 promoter remodeling in an epigenetic methionine-induced mouse model of schizophrenia. Proceedings of the National Academy of Sciences of the United States of America. 102: 12578-83. PMID 16113080 DOI: 10.1073/Pnas.0505394102  0.714
2005 Sharma RP, Grayson DR, Guidotti A, Costa E. Chromatin, DNA methylation and neuron gene regulation--the purpose of the package. Journal of Psychiatry & Neuroscience : Jpn. 30: 257-63. PMID 16049569  0.679
2005 Matsumoto K, Pinna G, Puia G, Guidotti A, Costa E. Social isolation stress-induced aggression in mice: a model to study the pharmacology of neurosteroidogenesis. Stress (Amsterdam, Netherlands). 8: 85-93. PMID 16019600 DOI: 10.1080/10253890500159022  0.719
2005 Auta J, Costa E, Davis JM, Guidotti A. Imidazenil: an antagonist of the sedative but not the anticonvulsant action of diazepam. Neuropharmacology. 49: 425-9. PMID 15964602 DOI: 10.1016/j.neuropharm.2005.04.005  0.728
2005 Grayson DR, Jia X, Chen Y, Sharma RP, Mitchell CP, Guidotti A, Costa E. Reelin promoter hypermethylation in schizophrenia. Proceedings of the National Academy of Sciences of the United States of America. 102: 9341-6. PMID 15961543 DOI: 10.1073/Pnas.0503736102  0.7
2005 Guidotti A, Auta J, Davis JM, Dong E, Grayson DR, Veldic M, Zhang X, Costa E. GABAergic dysfunction in schizophrenia: new treatment strategies on the horizon. Psychopharmacology. 180: 191-205. PMID 15864560 DOI: 10.1007/S00213-005-2212-8  0.751
2005 Tremolizzo L, Doueiri MS, Dong E, Grayson DR, Davis J, Pinna G, Tueting P, Rodriguez-Menendez V, Costa E, Guidotti A. Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice. Biological Psychiatry. 57: 500-9. PMID 15737665 DOI: 10.1016/J.Biopsych.2004.11.046  0.741
2005 Veldic M, Guidotti A, Maloku E, Davis JM, Costa E. In psychosis, cortical interneurons overexpress DNA-methyltransferase 1. Proceedings of the National Academy of Sciences of the United States of America. 102: 2152-7. PMID 15684088 DOI: 10.1073/pnas.0409665102  0.734
2005 Pinna G, Costa E, Guidotti A. Changes in brain testosterone and allopregnanolone biosynthesis elicit aggressive behavior. Proceedings of the National Academy of Sciences of the United States of America. 102: 2135-40. PMID 15677716 DOI: 10.1073/pnas.0409643102  0.689
2005 Noh JS, Sharma RP, Veldic M, Salvacion AA, Jia X, Chen Y, Costa E, Guidotti A, Grayson DR. DNA methyltransferase 1 regulates reelin mRNA expression in mouse primary cortical cultures. Proceedings of the National Academy of Sciences of the United States of America. 102: 1749-54. PMID 15671176 DOI: 10.1073/Pnas.0409648102  0.725
2005 Costa E, Guidotti A, Veldić M. Should allosteric positive modulators of GABA(A) receptors be tested in the treatment of schizophrenia? Schizophrenia Research. 73: 367-8. PMID 15653283 DOI: 10.1016/j.schres.2004.08.005  0.717
2004 Pinna G, Agis-Balboa RC, Doueiri MS, Guidotti A, Costa E. Brain neurosteroids in gender-related aggression induced by social isolation. Critical Reviews in Neurobiology. 16: 75-82. PMID 15581402 DOI: 10.1615/CritRevNeurobiol.v16.i12.80  0.692
2004 Costa E, Davis JM, Dong E, Grayson DR, Guidotti A, Tremolizzo L, Veldic M. A GABAergic cortical deficit dominates schizophrenia pathophysiology. Critical Reviews in Neurobiology. 16: 1-23. PMID 15581395 DOI: 10.1615/Critrevneurobiol.V16.I12.10  0.74
2004 Carboni G, Tueting P, Tremolizzo L, Sugaya I, Davis J, Costa E, Guidotti A. Enhanced dizocilpine efficacy in heterozygous reeler mice relates to GABA turnover downregulation. Neuropharmacology. 46: 1070-81. PMID 15111013 DOI: 10.1016/J.Neuropharm.2004.02.001  0.731
2004 Pinna G, Costa E, Guidotti A. Fluoxetine and norfluoxetine stereospecifically facilitate pentobarbital sedation by increasing neurosteroids. Proceedings of the National Academy of Sciences of the United States of America. 101: 6222-5. PMID 15069199 DOI: 10.1073/pnas.0401479101  0.693
2004 Costa E, Grayson DR, Veldic M, Guidotti A. Neurochemical basis for an epigenetic vision of synaptic organization. International Review of Neurobiology. 59: 73-91. PMID 15006485 DOI: 10.1016/S0074-7742(04)59004-9  0.675
2004 Auta J, Costa E, Davis J, Guidotti A. Imidazenil: a potent and safe protective agent against diisopropyl fluorophosphate toxicity. Neuropharmacology. 46: 397-403. PMID 14975695 DOI: 10.1016/J.Neuropharm.2003.09.010  0.709
2004 Veldic M, Caruncho HJ, Liu WS, Davis J, Satta R, Grayson DR, Guidotti A, Costa E. DNA-methyltransferase 1 mRNA is selectively overexpressed in telencephalic GABAergic interneurons of schizophrenia brains. Proceedings of the National Academy of Sciences of the United States of America. 101: 348-53. PMID 14684836 DOI: 10.1073/Pnas.2637013100  0.743
2003 Costa E, Grayson DR, Guidotti A. Epigenetic downregulation of GABAergic function in schizophrenia: potential for pharmacological intervention? Molecular Interventions. 3: 220-9. PMID 14993449 DOI: 10.1124/Mi.3.4.220  0.662
2003 Costa E, Grayson DR, Mitchell CP, Tremolizzo L, Veldic M, Guidotti A. GABAergic cortical neuron chromatin as a putative target to treat schizophrenia vulnerability. Critical Reviews in Neurobiology. 15: 121-42. PMID 14977367 DOI: 10.1615/Critrevneurobiol.V15.I2.20  0.729
2003 Dong E, Caruncho H, Liu WS, Smalheiser NR, Grayson DR, Costa E, Guidotti A. A reelin-integrin receptor interaction regulates Arc mRNA translation in synaptoneurosomes. Proceedings of the National Academy of Sciences of the United States of America. 100: 5479-84. PMID 12707415 DOI: 10.1073/Pnas.1031602100  0.714
2003 Larson J, Hoffman JS, Guidotti A, Costa E. Olfactory discrimination learning deficit in heterozygous reeler mice. Brain Research. 971: 40-6. PMID 12691835 DOI: 10.1016/S0006-8993(03)02353-9  0.659
2003 Pinna G, Dong E, Matsumoto K, Costa E, Guidotti A. In socially isolated mice, the reversal of brain allopregnanolone down-regulation mediates the anti-aggressive action of fluoxetine. Proceedings of the National Academy of Sciences of the United States of America. 100: 2035-40. PMID 12571361 DOI: 10.1073/pnas.0337642100  0.675
2003 Hankiewicz J, Brint SU, Guidotti A, Costa E, Fiat D. In vivo natural-abundance17O/1H MRI of rhesus monkey body in a whole-body scanner Applied Magnetic Resonance. 24: 423-427. DOI: 10.1007/Bf03166945  0.626
2002 Costa E, Chen Y, Davis J, Dong E, Noh JS, Tremolizzo L, Veldic M, Grayson DR, Guidotti A. REELIN and schizophrenia: a disease at the interface of the genome and the epigenome. Molecular Interventions. 2: 47-57. PMID 14993361 DOI: 10.1124/Mi.2.1.47  0.716
2002 Tremolizzo L, Carboni G, Ruzicka WB, Mitchell CP, Sugaya I, Tueting P, Sharma R, Grayson DR, Costa E, Guidotti A. An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability. Proceedings of the National Academy of Sciences of the United States of America. 99: 17095-100. PMID 12481028 DOI: 10.1073/Pnas.262658999  0.702
2002 Costa E, Auta J, Grayson DR, Matsumoto K, Pappas GD, Zhang X, Guidotti A. GABAA receptors and benzodiazepines: a role for dendritic resident subunit mRNAs. Neuropharmacology. 43: 925-37. PMID 12423662 DOI: 10.1016/S0028-3908(02)00199-5  0.73
2002 Rodriguez MA, Caruncho HJ, Costa E, Pesold C, Liu WS, Guidotti A. In Patas monkey, glutamic acid decarboxylase-67 and reelin mRNA coexpression varies in a manner dependent on layers and cortical areas. The Journal of Comparative Neurology. 451: 279-88. PMID 12210139 DOI: 10.1002/cne.10341  0.696
2002 Kim HM, Qu T, Kriho V, Lacor P, Smalheiser N, Pappas GD, Guidotti A, Costa E, Sugaya K. Reelin function in neural stem cell biology. Proceedings of the National Academy of Sciences of the United States of America. 99: 4020-5. PMID 11891343 DOI: 10.1073/Pnas.062698299  0.681
2002 Costa E, Davis J, Pesold C, Tueting P, Guidotti A. The heterozygote reeler mouse as a model for the development of a new generation of antipsychotics. Current Opinion in Pharmacology. 2: 56-62. PMID 11786309 DOI: 10.1016/S1471-4892(01)00121-7  0.731
2001 Guidotti A, Dong E, Matsumoto K, Pinna G, Rasmusson AM, Costa E. The socially-isolated mouse: a model to study the putative role of allopregnanolone and 5alpha-dihydroprogesterone in psychiatric disorders. Brain Research. Brain Research Reviews. 37: 110-5. PMID 11744079 DOI: 10.1016/S0165-0173(01)00129-1  0.705
2001 Costa E, Davis J, Grayson DR, Guidotti A, Pappas GD, Pesold C. Dendritic spine hypoplasticity and downregulation of reelin and GABAergic tone in schizophrenia vulnerability. Neurobiology of Disease. 8: 723-42. PMID 11592844 DOI: 10.1006/Nbdi.2001.0436  0.728
2001 Izzo E, Auta J, Impagnatiello F, Pesold C, Guidotti A, Costa E. Glutamic acid decarboxylase and glutamate receptor changes during tolerance and dependence to benzodiazepines. Proceedings of the National Academy of Sciences of the United States of America. 98: 3483-8. PMID 11248104 DOI: 10.1073/pnas.051628698  0.723
2001 Liu WS, Pesold C, Rodriguez MA, Carboni G, Auta J, Lacor P, Larson J, Condie BG, Guidotti A, Costa E. Down-regulation of dendritic spine and glutamic acid decarboxylase 67 expressions in the reelin haploinsufficient heterozygous reeler mouse. Proceedings of the National Academy of Sciences of the United States of America. 98: 3477-82. PMID 11248103 DOI: 10.1073/Pnas.051614698  0.701
2001 Dong E, Matsumoto K, Uzunova V, Sugaya I, Takahata H, Nomura H, Watanabe H, Costa E, Guidotti A. Brain 5alpha-dihydroprogesterone and allopregnanolone synthesis in a mouse model of protracted social isolation. Proceedings of the National Academy of Sciences of the United States of America. 98: 2849-54. PMID 11226329 DOI: 10.1073/pnas.051628598  0.701
2000 Guidotti A, Auta J, Davis JM, Di-Giorgi-Gerevini V, Dwivedi Y, Grayson DR, Impagnatiello F, Pandey G, Pesold C, Sharma R, Uzunov D, Costa E, DiGiorgi Gerevini V. Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study. Archives of General Psychiatry. 57: 1061-9. PMID 11074872 DOI: 10.1001/Archpsyc.57.11.1061  0.733
2000 Guidotti A, Pesold C, Costa E. New neurochemical markers for psychosis: a working hypothesis of their operation. Neurochemical Research. 25: 1207-18. PMID 11059795 DOI: 10.1023/A:1007635927069  0.735
2000 Auta J, Lecca D, Nelson M, Guidotti A, Overstreet DH, Costa E, Javaid JI. Expression and function of striatal nAChRs differ in the flinders sensitive (FSL) and resistant (FRL) rat lines. Neuropharmacology. 39: 2624-31. PMID 11044732 DOI: 10.1016/S0028-3908(00)00082-4  0.696
2000 Rodriguez MA, Pesold C, Liu WS, Kriho V, Guidotti A, Pappas GD, Costa E. Colocalization of integrin receptors and reelin in dendritic spine postsynaptic densities of adult nonhuman primate cortex. Proceedings of the National Academy of Sciences of the United States of America. 97: 3550-5. PMID 10725376 DOI: 10.1073/pnas.050589797  0.717
2000 Lacor PN, Grayson DR, Auta J, Sugaya I, Costa E, Guidotti A. Reelin secretion from glutamatergic neurons in culture is independent from neurotransmitter regulation. Proceedings of the National Academy of Sciences of the United States of America. 97: 3556-61. PMID 10725375 DOI: 10.1073/Pnas.050589597  0.705
2000 Auta J, Guidotti A, Costa E. Imidazenil prevention of alprazolam-induced acquisition deficit in patas monkeys is devoid of tolerance. Proceedings of the National Academy of Sciences of the United States of America. 97: 2314-9. PMID 10696114 DOI: 10.1073/pnas.97.5.2314  0.704
2000 Smalheiser NR, Costa E, Guidotti A, Impagnatiello F, Auta J, Lacor P, Kriho V, Pappas GD. Expression of reelin in adult mammalian blood, liver, pituitary pars intermedia, and adrenal chromaffin cells. Proceedings of the National Academy of Sciences of the United States of America. 97: 1281-6. PMID 10655522 DOI: 10.1073/pnas.97.3.1281  0.675
2000 Smalheiser NR, Costa E, Guidotti A, Impagnatiello F, Auta J, Lacor P, Kriho V, Pappas GD. 474. Reelin, a protein regulating neural development, is expressed in the blood in adult mammals Biological Psychiatry. 47. DOI: 10.1016/S0006-3223(00)00744-7  0.674
2000 Guidotti A, Uzunova V, Uzunov DP, Matsumoto K, Mienville JM, Puia G, Costa E. 408. Putative role of allopregnanolone in psychiatric disorders Biological Psychiatry. 47. DOI: 10.1016/S0006-3223(00)00678-8  0.693
2000 Costa E, Pesold C, Auta J, Caruncho H, Davis J, Davidkova G, Dwivedi Y, Grayson D, Rodriguez M, Uzunov D, Guidotti A. 223. Reelin and GAD67 downregulation and psychosis vulnerability Biological Psychiatry. 47: S68. DOI: 10.1016/S0006-3223(00)00487-X  0.674
2000 Tueting P, Carboni G, Costa E, Guidotti A, Sugaya I. 83. Pharmacology of psychotic-like abnormalities expressed by reeler heterozygous mouse Biological Psychiatry. 47. DOI: 10.1016/S0006-3223(00)00345-0  0.691
1999 Auta J, Longone P, Guidotti A, Costa E. The regulation of hippocampal nicotinic acetylcholine receptors (nAChRs) after a protracted treatment with selective or nonselective nAChR agonists. Journal of Molecular Neuroscience : Mn. 13: 31-45. PMID 10691290 DOI: 10.1385/JMN:13:1-2:31  0.709
1999 Saito M, Saito M, Berg MJ, Guidotti A, Marks N. Gangliosides attenuate ethanol-induced apoptosis in rat cerebellar granule neurons. Neurochemical Research. 24: 1107-15. PMID 10485581 DOI: 10.1023/A:1020704218574  0.301
1999 Matsumoto K, Uzunova V, Pinna G, Taki K, Uzunov DP, Watanabe H, Mienville JM, Guidotti A, Costa E. Permissive role of brain allopregnanolone content in the regulation of pentobarbital-induced righting reflex loss. Neuropharmacology. 38: 955-63. PMID 10428414 DOI: 10.1016/S0028-3908(99)00018-0  0.737
1999 Tueting P, Costa E, Dwivedi Y, Guidotti A, Impagnatiello F, Manev R, Pesold C. The phenotypic characteristics of heterozygous reeler mouse. Neuroreport. 10: 1329-34. PMID 10363948  0.676
1999 Pesold C, Liu WS, Guidotti A, Costa E, Caruncho HJ. Cortical bitufted, horizontal, and Martinotti cells preferentially express and secrete reelin into perineuronal nets, nonsynaptically modulating gene expression. Proceedings of the National Academy of Sciences of the United States of America. 96: 3217-22. PMID 10077664 DOI: 10.1073/pnas.96.6.3217  0.703
1998 Liao Y, Kozikowski AP, Guidotti A, Costa E. Synthesis and pharmacological evaluation of benzofuran-acetamides as "antineophobic" mitochondrial DBI receptor complex ligands. Bioorganic & Medicinal Chemistry Letters. 8: 2099-102. PMID 9873493 DOI: 10.1016/S0960-894X(98)00374-6  0.661
1998 Impagnatiello F, Guidotti AR, Pesold C, Dwivedi Y, Caruncho H, Pisu MG, Uzunov DP, Smalheiser NR, Davis JM, Pandey GN, Pappas GD, Tueting P, Sharma RP, Costa E. A decrease of reelin expression as a putative vulnerability factor in schizophrenia. Proceedings of the National Academy of Sciences of the United States of America. 95: 15718-23. PMID 9861036 DOI: 10.1073/Pnas.95.26.15718  0.714
1998 Longone P, Impagnatiello F, Mienville JM, Costa E, Guidotti A. Changes in AMPA receptor-spliced variant expression and shift in AMPA receptor spontaneous desensitization pharmacology during cerebellar granule cell maturation in vitro. Journal of Molecular Neuroscience : Mn. 11: 23-41. PMID 9826784 DOI: 10.1385/JMN:11:1:23  0.709
1998 Guidotti A, Costa E. Can the antidysphoric and anxiolytic profiles of selective serotonin reuptake inhibitors be related to their ability to increase brain 3 alpha, 5 alpha-tetrahydroprogesterone (allopregnanolone) availability? Biological Psychiatry. 44: 865-73. PMID 9807641 DOI: 10.1016/S0006-3223(98)00070-5  0.742
1998 Uzunova V, Sheline Y, Davis JM, Rasmusson A, Uzunov DP, Costa E, Guidotti A. Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine. Proceedings of the National Academy of Sciences of the United States of America. 95: 3239-44. PMID 9501247 DOI: 10.1073/Pnas.95.6.3239  0.717
1998 Pesold C, Impagnatiello F, Pisu MG, Uzunov DP, Costa E, Guidotti A, Caruncho HJ. Reelin is preferentially expressed in neurons synthesizing gamma-aminobutyric acid in cortex and hippocampus of adult rats. Proceedings of the National Academy of Sciences of the United States of America. 95: 3221-6. PMID 9501244 DOI: 10.1073/pnas.95.6.3221  0.703
1997 Pesold C, Caruncho HJ, Impagnatiello F, Berg MJ, Fritschy JM, Guidotti A, Costa E. Tolerance to diazepam and changes in GABA(A) receptor subunit expression in rat neocortical areas. Neuroscience. 79: 477-87. PMID 9200730 DOI: 10.1016/S0306-4522(96)00609-4  0.73
1997 Impagnatiello F, Oberto A, Longone P, Costa E, Guidotti A. 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide: a partial modulator of AMPA receptor desensitization devoid of neurotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 94: 7053-8. PMID 9192690 DOI: 10.1073/pnas.94.13.7053  0.734
1997 Caruncho HJ, Guidotti A, Lindstrom J, Costa E, Pesold C. Subcellular localization of the alpha 7 nicotinic receptor in rat cerebellar granule cell layer. Neuroreport. 8: 1431-3. PMID 9172148 DOI: 10.1097/00001756-199704140-00021  0.683
1996 Longone P, Impagnatiello F, Guidotti A, Costa E. Reversible modification of GABAA receptor subunit mRNA expression during tolerance to diazepam-induced cognition dysfunction. Neuropharmacology. 35: 1465-73. PMID 9014162 DOI: 10.1016/S0028-3908(96)00071-8  0.729
1996 Arai A, Guidotti A, Costa E, Lynch G. Effect of the AMPA receptor modulator IDRA 21 on LTP in hippocampal slices. Neuroreport. 7: 2211-5. PMID 8930991 DOI: 10.1097/00001756-199609020-00031  0.688
1996 Uzunov DP, Cooper TB, Costa E, Guidotti A. Fluoxetine-elicited changes in brain neurosteroid content measured by negative ion mass fragmentography. Proceedings of the National Academy of Sciences of the United States of America. 93: 12599-604. PMID 8901628  0.673
1996 Costa E, Guidotti A. Benzodiazepines on trial: a research strategy for their rehabilitation. Trends in Pharmacological Sciences. 17: 192-200. PMID 8669126  0.7
1996 Costa E, Auta J, Thompson JM, Guidotti A. Positive allosteric modulation of AMPA or GABAAreceptors antagonizes alprazolam induced learning impairment in monkeys European Neuropsychopharmacology. 6: 152. DOI: 10.1016/0924-977X(96)88008-4  0.652
1996 Guidotti A, Uzunov DP, Costa E. Fluoxetine treatment selectively causes brain accumulation of allopregnanolone (allo) Biological Psychiatry. 39: 592-593. DOI: 10.1016/0006-3223(96)84262-4  0.664
1995 Auta J, Faust WB, Lambert P, Guidotti A, Costa E, Moerschbaecher JM. Comparison of the effects of full and partial allosteric modulators of GABA(A) receptors on complex behavioral processes in monkeys. Behavioural Pharmacology. 6: 323-332. PMID 11224341  0.675
1995 Cheney DL, Uzunov D, Costa E, Guidotti A. Gas chromatographic-mass fragmentographic quantitation of 3 alpha-hydroxy-5 alpha-pregnan-20-one (allopregnanolone) and its precursors in blood and brain of adrenalectomized and castrated rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 4641-50. PMID 7790929  0.685
1995 Thompson DM, Guidotti A, DiBella M, Costa E. 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide (IDRA 21), a congener of aniracetam, potently abates pharmacologically induced cognitive impairments in patas monkeys. Proceedings of the National Academy of Sciences of the United States of America. 92: 7667-71. PMID 7644474 DOI: 10.1073/pnas.92.17.7667  0.681
1995 Uzunov DP, Zivkovich I, Pirkle WH, Costa E, Guidotti A. Enantiomeric resolution with a new chiral stationary phase of 7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide, a cognition-enhancing benzothiadiazine derivative. Journal of Pharmaceutical Sciences. 84: 937-42. PMID 7500277 DOI: 10.1002/jps.2600840807  0.653
1995 Costa E, Thompson DM, Auta J, Guidotti A. Imidazenil: A Potent Benzodiazepine Partial Positive Modulator of GABAergic Transmission Virtually Devoid of Tolerance Liability Cns Drug Reviews. 1: 168-189. DOI: 10.1111/J.1527-3458.1995.TB00282.X  0.671
1994 Costa E, Auta J, Guidotti A, Korneyev A, Romeo E. The pharmacology of neurosteroidogenesis. The Journal of Steroid Biochemistry and Molecular Biology. 49: 385-9. PMID 8043504 DOI: 10.1016/0960-0760(94)90284-4  0.711
1994 Costa E, Armstrong DM, Guidotti A, Kharlamov A, Kiedrowski L, Manev H, Polo A, Wroblewski JT. Gangliosides in the protection against glutamate excitotoxicity. Progress in Brain Research. 101: 357-73. PMID 8029464 DOI: 10.1016/S0079-6123(08)61962-7  0.742
1994 Kharlamov A, Zivkovic I, Polo A, Armstrong DM, Costa E, Guidotti A. LIGA20, a lyso derivative of ganglioside GM1, given orally after cortical thrombosis reduces infarct size and associated cognition deficit. Proceedings of the National Academy of Sciences of the United States of America. 91: 6303-7. PMID 8022776 DOI: 10.1073/pnas.91.14.6303  0.674
1994 Perillo MA, Guidotti A, Costa E, Yu RK, Maggio B. Modulation of phospholipases A2 and C activities against dilauroylphosphorylcholine in mixed monolayers with semisynthetic derivatives of ganglioside and sphingosine. Molecular Membrane Biology. 11: 119-26. PMID 7920864 DOI: 10.3109/09687689409162229  0.65
1994 Polo A, Kirschner G, Guidotti A, Costa E. Brain content of glycosphingolipids after oral administration of monosialogangliosides GM1 and LIGA20 to rats. Molecular and Chemical Neuropathology / Sponsored by the International Society For Neurochemistry and the World Federation of Neurology and Research Groups On Neurochemistry and Cerebrospinal Fluid. 21: 41-53. PMID 7910019 DOI: 10.1007/Bf03160083  0.697
1994 Rius RA, Guidotti A, Costa E. Pituitary adenylate cyclase activating polypeptide (PACAP) potently enhances tyrosine hydroxylase (TH) expression in adrenal chromaffin cells. Life Sciences. 54: 1735-43. PMID 7909910 DOI: 10.1016/0024-3205(94)00614-8  0.68
1994 van Kammen DP, Guidotti A, Neylan T, Guarneri P, Kelley ME, Gurklis J, Gilbertson MW, Peters JL, Costa E. CSF levels of diazepam-binding inhibitor correlate with REM latency in schizophrenia, a pilot study. European Archives of Psychiatry and Clinical Neuroscience. 244: 216-22. PMID 7888420 DOI: 10.1007/Bf02190401  0.643
1994 Costa E, Cheney DL, Grayson DR, Korneyev A, Longone P, Pani L, Romeo E, Zivkovich E, Guidotti A. Pharmacology of neurosteroid biosynthesis. Role of the mitochondrial DBI receptor (MDR) complex. Annals of the New York Academy of Sciences. 746: 223-42. PMID 7825880  0.665
1993 Kozikowski AP, Ma D, Brewer J, Sun S, Costa E, Romeo E, Guidotti A. Chemistry, binding affinities, and behavioral properties of a new class of "antineophobic" mitochondrial DBI receptor complex (mDRC) ligands. Journal of Medicinal Chemistry. 36: 2908-20. PMID 8411007 DOI: 10.1021/Jm00072A010  0.693
1993 Korneyev A, Pan BS, Polo A, Romeo E, Guidotti A, Costa E. Stimulation of brain pregnenolone synthesis by mitochondrial diazepam binding inhibitor receptor ligands in vivo. Journal of Neurochemistry. 61: 1515-24. PMID 8397297 DOI: 10.1111/J.1471-4159.1993.Tb13647.X  0.703
1993 Cavallaro S, Pani L, Guidotti A, Costa E. ACTH-induced mitochondrial DBI receptor (MDR) and diazepam binding inhibitor (DBI) expression in adrenals of hypophysectomized rats is not cause-effect related to its immediate steroidogenic action. Life Sciences. 53: 1137-47. PMID 8396705 DOI: 10.1016/0024-3205(93)90550-M  0.692
1993 Korneyev AY, Costa E, Guidotti A. During anesthetic-induced activation of hypothalamic pituitary adrenal axis, blood-borne steroids fail to contribute to the anesthetic effect. Neuroendocrinology. 57: 559-65. PMID 8391666 DOI: 10.1159/000126405  0.689
1993 van Kammen DP, Guidotti A, Kelley ME, Gurklis J, Guarneri P, Gilbertson MW, Yao JK, Peters J, Costa E. CSF diazepam binding inhibitor and schizophrenia: clinical and biochemical relationships. Biological Psychiatry. 34: 515-22. PMID 8274578 DOI: 10.1016/0006-3223(93)90193-H  0.698
1993 Perillo MA, Polo A, Guidotti A, Costa E, Maggio B. Molecular parameters of semisynthetic derivatives of gangliosides and sphingosine in monolayers at the air-water interface. Chemistry and Physics of Lipids. 65: 225-38. PMID 8269552 DOI: 10.1016/0009-3084(93)90020-4  0.648
1993 Korneyev A, Guidotti A, Costa E. Regional and interspecies differences in brain progesterone metabolism. Journal of Neurochemistry. 61: 2041-7. PMID 8245959 DOI: 10.1111/J.1471-4159.1993.Tb07440.X  0.673
1993 Manev H, Guidotti A, Costa E. Protection by gangliosides against glutamate excitotoxicity. Advances in Lipid Research. 25: 269-88. PMID 8103620  0.473
1993 Lombardi G, Szekely AM, Bristol LA, Guidotti A, Manev H. Induction of ornithine decarboxylase by N-methyl-D-aspartate receptor activation is unrelated to potentiation of glutamate excitotoxicity by polyamines in cerebellar granule neurons. Journal of Neurochemistry. 60: 1317-24. PMID 8095973 DOI: 10.1111/J.1471-4159.1993.Tb03292.X  0.473
1993 Costa E, Armstrong D, Guidotti A, Kharlamov A, Kiedrowski L, Wroblewski JT. Ganglioside GM1 and its semisynthetic lysogangliosides reduce glutamate neurotoxicity by a novel mechanism. Advances in Experimental Medicine and Biology. 341: 129-41. PMID 7906915 DOI: 10.1007/978-1-4615-2484-7_12  0.702
1993 Kharlamov A, Guidotti A, Costa E, Hayes R, Armstrong D. Semisynthetic sphingolipids prevent protein kinase C translocation and neuronal damage in the perifocal area following a photochemically induced thrombotic brain cortical lesion The Journal of Neuroscience. 13: 2483-2494. DOI: 10.1523/Jneurosci.13-06-02483.1993  0.689
1993 Berkovich A, Ferrarese C, Cavaletti G, Alho H, Marzorati C, Bianchi G, Guidotti A, Costa E. Topology of two DBI receptors in human lymphocytes. Life Sciences. 52: 1265-1277. DOI: 10.1016/S0024-3205(05)80016-5  0.672
1992 Rothstein JD, Guidotti A, Costa E. Release of endogenous benzodiazepine receptor ligands (endozepines) from cultured neurons. Neuroscience Letters. 143: 210-4. PMID 1331901 DOI: 10.1016/0304-3940(92)90267-B  0.696
1992 Papadopoulos V, Guarneri P, Kreuger KE, Guidotti A, Costa E. Pregnenolone biosynthesis in C6-2B glioma cell mitochondria: regulation by a mitochondrial diazepam binding inhibitor receptor. Proceedings of the National Academy of Sciences of the United States of America. 89: 5113-7. PMID 1317581 DOI: 10.1073/Pnas.89.11.5113  0.685
1992 Rothstein JD, Garland W, Puia G, Guidotti A, Weber RJ, Costa E. Purification and characterization of naturally occurring benzodiazepine receptor ligands in rat and human brain. Journal of Neurochemistry. 58: 2102-15. PMID 1315376 DOI: 10.1111/J.1471-4159.1992.Tb10952.X  0.721
1992 Cavallaro S, Korneyev A, Guidotti A, Costa E. Diazepam-binding inhibitor (DBI)-processing products, acting at the mitochondrial DBI receptor, mediate adrenocorticotropic hormone-induced steroidogenesis in rat adrenal gland. Proceedings of the National Academy of Sciences of the United States of America. 89: 10598-602. PMID 1279686 DOI: 10.1073/Pnas.89.22.10598  0.689
1992 Peters JL, Kammen DPv, Guidotti A, Neylan T, Mouton A, Kelley ME, Gilbertson M, Gurklis J, Costa E. CSF levels of diazepam binding-inhibitor correlate with rem latency and slow wave sleep in schizophrenia Schizophrenia Research. 6: 126. DOI: 10.1016/0920-9964(92)90171-Z  0.637
1991 Ferrarese C, Guidotti A, Costa E, Miletich RS, Rice KC, de Costa BR, Fulham MJ, Di Chiro G. In vivo study of NMDA-sensitive glutamate receptor by fluorothienylcyclohexylpiperidine [correction of fluorothienylcycloexylpiperidine], a possible ligand for positron emission tomography. Neuropharmacology. 30: 899-905. PMID 1685770 DOI: 10.1016/0028-3908(91)90125-U  0.691
1991 Manev H, Favaron M, Siman R, Guidotti A, Costa E. Glutamate neurotoxicity is independent of calpain I inhibition in primary cultures of cerebellar granule cells. Journal of Neurochemistry. 57: 1288-95. PMID 1680162 DOI: 10.1111/J.1471-4159.1991.Tb08292.X  0.751
1991 Papadopoulos V, Berkovich A, Krueger KE, Costa E, Guidotti A. Diazepam binding inhibitor and its processing products stimulate mitochondrial steroid biosynthesis via an interaction with mitochondrial benzodiazepine receptors. Endocrinology. 129: 1481-8. PMID 1651852 DOI: 10.1210/Endo-129-3-1481  0.683
1991 Costa E, Guidotti A. Diazepam binding inhibitor (DBI): a peptide with multiple biological actions. Life Sciences. 49: 325-44. PMID 1649940 DOI: 10.1016/0024-3205(91)90440-M  0.714
1991 Massotti M, Slobodyansky E, Konkel D, Costa E, Guidotti A. Regulation of diazepam binding inhibitor in rat adrenal gland by adrenocorticotropin. Endocrinology. 129: 591-6. PMID 1649741 DOI: 10.1210/endo-129-2-591  0.688
1991 Guidotti A, Manev H, Costa E. Neuroprotective effects of glycosphingolipids in in-vitro and in-vivo models of neurotoxicity European Neuropsychopharmacology. 1: 248.  0.717
1990 Guarneri P, Berkovich A, Guidotti A, Costa E. A study of diazepam binding inhibitor (DBI) processing products in human cerebrospinal fluid and in postmortem human brain. Neuropharmacology. 29: 419-28. PMID 2356001 DOI: 10.1016/0028-3908(90)90162-K  0.681
1990 de Erausquin GA, Manev H, Guidotti A, Costa E, Brooker G. Gangliosides normalize distorted single-cell intracellular free Ca2+ dynamics after toxic doses of glutamate in cerebellar granule cells. Proceedings of the National Academy of Sciences of the United States of America. 87: 8017-21. PMID 2236016 DOI: 10.1073/Pnas.87.20.8017  0.735
1990 Manev H, Favaron M, De Erausquin G, Guidotti A, Brooker G, Costa E. Destabilization of ionized Ca2+ homeostasis in excitatory amino acid neurotoxicity: antagonism by glycosphingolipids. Cell Biology International Reports. 14: 3-14. PMID 2185894 DOI: 10.1016/0309-1651(90)90066-8  0.723
1990 Olasmaa M, Rothstein JD, Guidotti A, Weber RJ, Paul SM, Spector S, Zeneroli ML, Baraldi M, Costa E. Endogenous benzodiazepine receptor ligands in human and animal hepatic encephalopathy. Journal of Neurochemistry. 55: 2015-23. PMID 2172467 DOI: 10.1111/J.1471-4159.1990.Tb05790.X  0.682
1990 Manev H, Costa E, Wroblewski JT, Guidotti A. Abusive stimulation of excitatory amino acid receptors: a strategy to limit neurotoxicity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 4: 2789-97. PMID 2165013 DOI: 10.1096/Fasebj.4.10.2165013  0.765
1990 Manev H, Favaron M, Vicini S, Guidotti A. Ganglioside-mediated protection from glutamate-induced neuronal death. Acta Neurobiologiae Experimentalis. 50: 475-88. PMID 1983378  0.473
1990 Guidotti A, Manev H, Favaron M, Brooker G, Costa E. Protection by natural and semisynthetic gangliosides from Ca2(+)-dependent neurotoxicity caused by excitatory amino acid (EAA) neurotransmitters. Advances in Experimental Medicine and Biology. 268: 135-44. PMID 1981639 DOI: 10.1007/978-1-4684-5769-8_16  0.729
1990 Favaron M, Manev H, Siman R, Bertolino M, Szekely AM, DeErausquin G, Guidotti A, Costa E. Down-regulation of protein kinase C protects cerebellar granule neurons in primary culture from glutamate-induced neuronal death. Proceedings of the National Academy of Sciences of the United States of America. 87: 1983-7. PMID 1689850 DOI: 10.1073/Pnas.87.5.1983  0.757
1990 Manev H, Favaron M, Vicini S, Guidotti A, Costa E. Glutamate-induced neuronal death in primary cultures of cerebellar granule cells: protection by synthetic derivatives of endogenous sphingolipids. The Journal of Pharmacology and Experimental Therapeutics. 252: 419-27. PMID 1688945  0.473
1990 Guidotti A, Berkovich A, Muhkin A, Costa E. Diazepam-binding inhibitor: response to Knudsen & Nielsen Biochemical Journal. 265: 928-929. DOI: 10.1042/Bj2650928  0.654
1990 Zeneroli M, Baraldi M, Olusmaa M, Rothstein J, Guidotti A, Costa E. Endogenous benzodiazepines in a rat model of hepatic encephalopathy Journal of Hepatology. 11: S66. DOI: 10.1016/0168-8278(90)91599-R  0.651
1990 Giusti P, Guidotti A, Danysz W, Auta J, Costa E. Neuropharmacological evidence for an interaction between the GABA uptake inhibitor Cl‐966 and anxiolytic benzodiazepines Drug Development Research. 21: 217-225. DOI: 10.1002/Ddr.430210307  0.72
1989 Roy A, Pickar D, Gold P, Barbaccia M, Guidotti A, Costa E, Linnoila M. Diazepam-binding inhibitor and corticotropin-releasing hormone in cerebrospinal fluid. Acta Psychiatrica Scandinavica. 80: 287-91. PMID 2816471 DOI: 10.1111/j.1600-0447.1989.tb01339.x  0.662
1989 Slobodyansky E, Guidotti A, Wambebe C, Berkovich A, Costa E. Isolation and characterization of a rat brain triakontatetraneuropeptide, a posttranslational product of diazepam binding inhibitor: specific action at the Ro 5-4864 recognition site. Journal of Neurochemistry. 53: 1276-84. PMID 2769267 DOI: 10.1111/J.1471-4159.1989.Tb07425.X  0.719
1989 Manev H, Favaron M, Guidotti A, Costa E. Delayed increase of Ca2+ influx elicited by glutamate: role in neuronal death. Molecular Pharmacology. 36: 106-12. PMID 2568579  0.473
1989 Olasmaa M, Guidotti A, Costa E, Rothstein JD, Goldman ME, Weber RJ, Paul SM. Endogenous benzodiazepines in hepatic encephalopathy. Lancet. 1: 491-2. PMID 2563854 DOI: 10.1016/S0140-6736(89)91384-6  0.637
1989 Rothstein JD, McKhann G, Guarneri P, Barbaccia ML, Guidotti A, Costa E. Cerebrospinal fluid content of diazepam binding inhibitor in chronic hepatic encephalopathy. Annals of Neurology. 26: 57-62. PMID 2549847 DOI: 10.1002/Ana.410260109  0.686
1988 Barbaccia ML, Costa E, Guidotti A. Endogenous ligands for high-affinity recognition sites of psychotropic drugs. Annual Review of Pharmacology and Toxicology. 28: 451-76. PMID 3289493 DOI: 10.1146/annurev.pa.28.040188.002315  0.704
1988 Favaron M, Manev H, Alho H, Bertolino M, Ferret B, Guidotti A, Costa E. Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortex. Proceedings of the National Academy of Sciences of the United States of America. 85: 7351-5. PMID 2902628 DOI: 10.1073/Pnas.85.19.7351  0.752
1987 Ferrarese C, Vaccarino F, Alho H, Mellstrom B, Costa E, Guidotti A. Subcellular location and neuronal release of diazepam binding inhibitor. Journal of Neurochemistry. 48: 1093-102. PMID 3819722  0.711
1987 Costa E, Berkovich A, Guidotti A. The regulation of GABAergic receptors by a novel family of endogenous neuropeptides. Life Sciences. 41: 799-803. PMID 3039273 DOI: 10.1016/0024-3205(87)90166-4  0.678
1987 Miyata M, Mocchetti I, Ferrarese C, Guidotti A, Costa E. Protracted treatment with diazepam increases the turnover of putative endogenous ligands for the benzodiazepine/beta-carboline recognition site. Proceedings of the National Academy of Sciences of the United States of America. 84: 1444-8. PMID 3029781 DOI: 10.1073/Pnas.84.5.1444  0.709
1987 Novelli A, Nicoletti F, Wroblewski JT, Alho H, Costa E, Guidotti A. Excitatory amino acid receptors coupled with guanylate cyclase in primary cultures of cerebellar granule cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 7: 40-7. PMID 2879898 DOI: 10.1523/Jneurosci.07-01-00040.1987  0.35
1987 Vaccarino F, Guidotti A, Costa E. Ganglioside inhibition of glutamate-mediated protein kinase C translocation in primary cultures of cerebellar neurons. Proceedings of the National Academy of Sciences of the United States of America. 84: 8707-11. PMID 2825205 DOI: 10.1073/Pnas.84.23.8707  0.695
1987 Ferrarese C, Alho H, Guidotti A, Costa E. Co-localization and co-release of GABA and putative allosteric modulators of GABA receptor. Neuropharmacology. 26: 1011-8. PMID 2821427  0.713
1987 Novelli A, Nicoletti F, Wroblewski J, Alho H, Costa E, Guidotti A. Excitatory amino acid receptors coupled with guanylate cyclase in primary cultures of cerebellar granule cells The Journal of Neuroscience. 7: 40-47. DOI: 10.1523/JNEUROSCI.07-01-00040.1987  0.711
1986 Ferrero P, Costa E, Conti-Tronconi B, Guidotti A. A diazepam binding inhibitor (DBI)-like neuropeptide is detected in human brain. Brain Research. 399: 136-42. PMID 3801915 DOI: 10.1016/0006-8993(86)90607-4  0.692
1986 Ferrero P, Santi MR, Conti-Tronconi B, Costa E, Guidotti A. Study of an octadecaneuropeptide derived from diazepam binding inhibitor (DBI): biological activity and presence in rat brain. Proceedings of the National Academy of Sciences of the United States of America. 83: 827-31. PMID 3456171 DOI: 10.1073/Pnas.83.3.827  0.705
1986 Costa E, Alho H, Santi MR, Ferrero P, Guidotti A. Cotransmission at GABAergic synapses. Progress in Brain Research. 68: 343-56. PMID 3031734 DOI: 10.1016/S0079-6123(08)60250-2  0.717
1986 Barbaccia ML, Costa E, Ferrero P, Guidotti A, Roy A, Sunderland T, Pickar D, Paul SM, Goodwin FK. Diazepam-binding inhibitor. A brain neuropeptide present in human spinal fluid: studies in depression, schizophrenia, and Alzheimer's disease. Archives of General Psychiatry. 43: 1143-7. PMID 3022663 DOI: 10.1001/Archpsyc.1986.01800120029007  0.702
1986 Gray PW, Glaister D, Seeburg PH, Guidotti A, Costa E. Cloning and expression of cDNA for human diazepam binding inhibitor, a natural ligand of an allosteric regulatory site of the gamma-aminobutyric acid type A receptor. Proceedings of the National Academy of Sciences of the United States of America. 83: 7547-51. PMID 3020548 DOI: 10.1073/pnas.83.19.7547  0.691
1986 Nicoletti F, Wroblewski JT, Novelli A, Guidotti A, Costa E. Excitatory amino acid signal transduction in cerebellar cell cultures. Functional Neurology. 1: 345-9. PMID 2886406  0.363
1986 Nicoletti F, Wroblewski J, Novelli A, Alho H, Guidotti A, Costa E. The activation of inositol phospholipid metabolism as a signal- transducing system for excitatory amino acids in primary cultures of cerebellar granule cells The Journal of Neuroscience. 6: 1905-1911. DOI: 10.1523/Jneurosci.06-07-01905.1986  0.709
1985 Vaccarino F, Tronconi BM, Panula P, Guidotti A, Costa E. GABA-modulin: a synaptosomal basic protein that differs from small myelin basic protein of rat brain. Journal of Neurochemistry. 44: 278-90. PMID 3964832 DOI: 10.1111/J.1471-4159.1985.Tb07142.X  0.708
1985 Alho H, Costa E, Ferrero P, Fujimoto M, Cosenza-Murphy D, Guidotti A. Diazepam-binding inhibitor: a neuropeptide located in selected neuronal populations of rat brain. Science (New York, N.Y.). 229: 179-82. PMID 3892688 DOI: 10.1126/Science.3892688  0.736
1985 Bormann J, Ferrero P, Guidotti A, Costa E. Neuropeptide modulation of GABA receptor C1- channels. Regulatory Peptides. Supplement. 4: 33-8. PMID 2414820 DOI: 10.1016/0167-0115(85)90215-0  0.707
1985 Guidotti A, Ferrero P, Santi MR, Alho H, Vicini S, Costa E. Gamma-aminobutyric acid and chloride channels: regulation by neuropeptides. Regulatory Peptides. Supplement. 4: 172-81. PMID 2414813  0.663
1985 Costa E, Guidotti A. Endogenous ligands for benzodiazepine recognition sites. Biochemical Pharmacology. 34: 3399-403. PMID 2413860 DOI: 10.1016/0006-2952(85)90709-9  0.648
1985 Mocchetti I, Guidotti A, Schwartz J, Costa E. Reserpine changes the dynamic state of enkephalin stores in rat striatum and adrenal medulla by different mechanisms The Journal of Neuroscience. 5: 3379-3385. DOI: 10.1523/Jneurosci.05-12-03379.1985  0.672
1984 Kataoka Y, Gutman Y, Guidotti A, Panula P, Wroblewski J, Cosenza-Murphy D, Wu JY, Costa E. Intrinsic GABAergic system of adrenal chromaffin cells. Proceedings of the National Academy of Sciences of the United States of America. 81: 3218-22. PMID 6328506 DOI: 10.1073/Pnas.81.10.3218  0.71
1984 Ferrero P, Guidotti A, Costa E. Increase in the Bmax of gamma-aminobutyric acid-A recognition sites in brain regions of mice receiving diazepam. Proceedings of the National Academy of Sciences of the United States of America. 81: 2247-51. PMID 6326115  0.715
1984 Ferrero P, Guidotti A, Conti-Tronconi B, Costa E. A brain octadecaneuropeptide generated by tryptic digestion of DBI (diazepam binding inhibitor) functions as a proconflict ligand of benzodiazepine recognition sites. Neuropharmacology. 23: 1359-62. PMID 6098849  0.692
1984 Costa E, Ferrari M, Ferrero P, Guidotti A. Multiple signals in GABAergic transmission: pharmacological consequences. Neuropharmacology. 23: 989-91. PMID 6090970 DOI: 10.1016/0028-3908(84)90016-9  0.648
1984 Corda MG, Ferrari M, Guidotti A, Konkel D, Costa E. Isolation, purification and partial sequence of a neuropeptide (diazepam-binding inhibitor) precursor of an anxiogenic putative ligand for benzodiazepine recognition site. Neuroscience Letters. 47: 319-24. PMID 6089051  0.676
1983 Guidotti A, Konkel DR, Ebstein B, Corda MG, Wise BC, Krutzsch H, Meek JL, Costa E. Isolation, characterization, and purification to homogeneity of a rat brain protein (GABA-modulin). Proceedings of the National Academy of Sciences of the United States of America. 79: 6084-8. PMID 6964401 DOI: 10.1073/PNAS.79.19.6084  0.701
1983 Ferrero P, Vaccarino F, Guidotti A, Costa E, Di Chiro G. In vivo modulation of brain dopamine recognition sites: a possible model for emission computed tomography studies. Neuropharmacology. 22: 791-5. PMID 6604240 DOI: 10.1016/0028-3908(83)90105-3  0.691
1983 Costa E, Corda MG, Guidotti A. On a brain polypeptide functioning as a putative effector for the recognition sites of benzodiazepine and beta-carboline derivatives. Neuropharmacology. 22: 1481-92. PMID 6322042  0.691
1983 Guidotti A, Corda MG, Wise BC, Vaccarino F, Costa E. GABAergic synapses. Supramolecular organization and biochemical regulation. Neuropharmacology. 22: 1471-9. PMID 6322041 DOI: 10.1016/0028-3908(83)90115-6  0.705
1983 Guidotti A, Forchetti CM, Corda MG, Konkel D, Bennett CD, Costa E. Isolation, characterization, and purification to homogeneity of an endogenous polypeptide with agonistic action on benzodiazepine receptors. Proceedings of the National Academy of Sciences of the United States of America. 80: 3531-5. PMID 6304714 DOI: 10.1073/PNAS.80.11.3531  0.68
1983 Corda MG, Blaker WD, Mendelson WB, Guidotti A, Costa E. beta-Carbolines enhance shock-induced suppression of drinking in rats. Proceedings of the National Academy of Sciences of the United States of America. 80: 2072-6. PMID 6300891 DOI: 10.1073/PNAS.80.7.2072  0.697
1983 Wise BC, Guidotti A, Costa E. Phosphorylation induces a decrease in the biological activity of the protein inhibitor (GABA-modulin) of gamma-aminobutyric acid binding sites. Proceedings of the National Academy of Sciences of the United States of America. 80: 886-90. PMID 6298780 DOI: 10.1073/PNAS.80.3.886  0.699
1982 Corda MG, Costa E, Guidotti A. Specific proconvulsant action of an imidazobenzodiazepine (RO 15-1788) on isoniazid convulsions. Neuropharmacology. 21: 91-4. PMID 6278356 DOI: 10.1016/0028-3908(82)90217-9  0.658
1981 Massotti M, Mazzari S, Schmid R, Guidotti A, Costa E. Endogenous inhibitors of Na+-independent [3H]GABA binding to crude synaptic membranes. Neurochemical Research. 6: 551-65. PMID 6269013 DOI: 10.1007/BF00964393  0.695
1981 Massotti M, Guidotti A, Costa E. Characterization of benzodiazepine and gamma-aminobutyric recognition sites and their endogenous modulators The Journal of Neuroscience. 1: 409-418. DOI: 10.1523/Jneurosci.01-04-00409.1981  0.697
1980 Cananzi AR, Costa E, Guidotti A. Potentiation by intraventricular muscimol of the anticonflict effect of benzodiazepines. Brain Research. 196: 447-53. PMID 6249449 DOI: 10.1016/0006-8993(80)90408-4  0.694
1980 Kumakura K, Karoum F, Guidotti A, Costa E. Modulation of nicotinic receptors by opiate receptor agonists in cultured adrenal chromaffin cells. Nature. 283: 489-92. PMID 6243403 DOI: 10.1038/283489A0  0.682
1980 Guidotti A, Baraldi M, Costa E. 1,4-Benzodiazepines and gamma-aminobutyric acid: pharmacological and biochemical correlates. Pharmacology. 19: 267-77. PMID 538081 DOI: 10.1159/000137322  0.708
1980 COSTA E, GUIDOTTI A, SAIANI L. Opiate receptors and adrenal medullary function (reply) Nature. 288: 304-304. DOI: 10.1038/288304A0  0.671
1980 Kumakura K, Guidotti A, Takemura H, Costa E. 94) Nicotinic cholinergic receptors of bovine adrenal chromaffin cells in the primary cultures. Japanese Journal of Pharmacology. 30: 105. DOI: 10.1016/s0021-5198(19)53428-x  0.665
1979 Baraldi M, Guidotti A, Schwartz JP, Costa E. GABA receptors in clonal cell lines: a model for study of benzodiazepine action at molecular level. Science. 205: 821-823. PMID 462192 DOI: 10.1126/Science.462192  0.724
1979 Guidotti A, Gale K, Suria A, Toffano G. Biochemical evidence for two classes of GABA receptors in rat brain. Brain Research. 172: 566-71. PMID 224975 DOI: 10.1016/0006-8993(79)90590-0  0.525
1979 Costa E, Guidotti A. Recent studies on the mechanism whereby benzodiazepines facilitate GABA-ergic transmission Advances in Experimental Medicine and Biology. 123: 371-378. PMID 42282 DOI: 10.1007/978-1-4899-5199-1_23  0.682
1979 Guidotti A, Baraldi M, Schwartz JP, Costa E. Molecular mechanisms regulating the interactions between the benzodiazepines and GABA receptors in the central nervous system Pharmacology, Biochemistry and Behavior. 10: 803-807. PMID 40254 DOI: 10.1016/0091-3057(79)90338-1  0.732
1979 Costa E, Guidotti A. Molecular mechanisms in the receptor action of benzodiazepines Annual Review of Pharmacology and Toxicology. 19: 531-545. PMID 36830 DOI: 10.1146/Annurev.Pa.19.040179.002531  0.699
1979 Gale K, Moroni F, Kumakura K, Guidotti A. Opiate-receptors in substantia nigra: role in the regulation of striatal tyrosine hydroxylase activity. Neuropharmacology. 18: 427-30. PMID 36574 DOI: 10.1016/0028-3908(79)90153-9  0.51
1978 Toffano G, Guidotti A, Costa E. Purification of an endogenous protein inhibitor of the high affinity binding of gamma-aminobutyric acid to synaptic membranes of rat brain. Proceedings of the National Academy of Sciences of the United States of America. 75: 4024-8. PMID 279020 DOI: 10.1073/PNAS.75.8.4024  0.702
1978 Costa E, Guidotti A, Toffano G. Molecular mechanisms mediating the action of diazepam on GABA receptors. The British Journal of Psychiatry : the Journal of Mental Science. 133: 239-48. PMID 212152 DOI: 10.1192/BJP.133.3.239  0.713
1978 Guidotti A, Toffano G, Costa E. An endogenous protein modulates the affinity of GABA and benzodiazepine receptors in rat brain. Nature. 275: 553-5. PMID 211441 DOI: 10.1038/275553A0  0.716
1978 Guidotti A, Gale K, Toffano G, Vargas FM. Tolerance to tyrosine hydroxylase activation in n. accumbens and c. striatum after repeated injections of "classical" and "atypical" antischizophrenic drugs. Life Sciences. 23: 501-5. PMID 29190 DOI: 10.1016/0024-3205(78)90161-3  0.437
1978 Lucchelli A, Guidotti A, Costa E. Stratial content of Ca2+-dependent regulator protein and dopaminergic receptor function. Brain Research. 155: 130-5. PMID 28815 DOI: 10.1016/0006-8993(78)90313-X  0.671
1978 Gale K, Costa E, Toffano G, Hong JS, Guidotti A. Evidence for a role of nigral gamma-aminobutyric acid and substance P in the haloperidol-induced activation of striatal tyrosine hydroxylase. The Journal of Pharmacology and Experimental Therapeutics. 206: 29-37. PMID 26799  0.482
1977 Biggio G, Costa E, Guidotti A. Regulation of 3', 5'-cyclic guanosine monophosphate content in deep cerebellar nuclei. Neuroscience. 2: 49-52. PMID 199855 DOI: 10.1016/0306-4522(77)90067-7  0.729
1977 Biggio G, Brodie BB, Costa E, Guidotti A. Mechanisms by which diazepam, muscimol, and other drugs change the content of cGMP in cerebellar cortex. Proceedings of the National Academy of Sciences of the United States of America. 74: 3592-6. PMID 198792 DOI: 10.1073/Pnas.74.8.3592  0.714
1977 Biggio G, Guidotti A, Costa E. On the mechanism of the decrease in cerebellar cyclic GMP content elicited by opiate receptor agonists. Naunyn-Schmiedeberg's Archives of Pharmacology. 296: 117-21. PMID 189228  0.683
1977 Guidotti A, Gale K. Participation of GABA receptors in the short-term activation of striatal tyrosine-3-monooxygenase elicited by neuroleptics. Advances in Biochemical Psychopharmacology. 16: 455-60. PMID 18893  0.499
1977 Guidotti A, Costa E. Trans-synaptic regulation of tyrosine 3-mono-oxygenase biosynthesis in rat adrenal medulla Biochemical Pharmacology. 26: 817-823. PMID 16614 DOI: 10.1016/0006-2952(77)90393-8  0.671
1977 Gale K, Guidotti A, Costa E. Dopamine-sensitive adenylate cyclase: location in substantia nigra. Science (New York, N.Y.). 195: 503-5. PMID 13499 DOI: 10.1126/Science.13499  0.736
1977 Guidotti A, Kurosawa A, Costa E. Association between the increase of cAMP content and the trans-synaptic induction of tyrosine hydroxylase in rat adrenal medulla. Studies with dexamethasone and reserpine. Naunyn-Schmiedeberg's Archives of Pharmacology. 295: 135-40. PMID 11421 DOI: 10.1007/BF00499445  0.678
1977 Szmigielski A, Guidotti A, Costa E. Endogenous protein kinase inhibitors. Purification, characterization, and distribution in different tissues. Journal of Biological Chemistry. 252: 3848-3853. DOI: 10.1016/s0021-9258(17)40329-2  0.645
1976 Naik SR, Guidotti A, Costa E. Central GABA receptor agonists: comparison of muscimol and baclofen. Neuropharmacology. 15: 479-84. PMID 185540 DOI: 10.1016/0028-3908(76)90058-7  0.699
1976 Gale KN, Guidotti A. GABA-mediated control of rat neostriatal tyrosine hydroxylase revealed by intranigral muscimol. Nature. 263: 691-3. PMID 10528  0.492
1976 Kurosawa A, Guidotti A, Costa E. Induction of tyrosine 3-monooxygenase in adrenal medulla: role of protein kinase activation and translocation. Science. 193: 691-693. PMID 7836 DOI: 10.1126/Science.7836  0.684
1976 Racagni G, Zsilla G, Guidotti A, Costa E. Accumulation of cGMP in striatum of rats injected with narcotic analgesics: antagonism by naltrexone. The Journal of Pharmacy and Pharmacology. 28: 258-60. PMID 6708 DOI: 10.1111/j.2042-7158.1976.tb04146.x  0.655
1976 Costa E, Kurosawa A, Guidotti A. Activation and nuclear translocation of protein kinase during transsynaptic induction of tyrosine 3-monooxygenase. Proceedings of the National Academy of Sciences of the United States of America. 73: 1058-62. PMID 4793 DOI: 10.1073/PNAS.73.4.1058  0.666
1976 Zivkovic B, Guidotti A, Costa E. The regulation of striatal tyrosine hydroxylase. Effects of gamma hydroxybutric acid and healperidol. Naunyn-Schmiedeberg's Archives of Pharmacology. 291: 193-200. PMID 629 DOI: 10.1007/BF00500049  0.682
1975 Mao CC, Guidotti A, Costa E. The regulation of cyclic guanosine monophosphate in rat cerebellum: possible involvement of putative amino acid neurotransmitters. Brain Research. 79: 510-4. PMID 4371516 DOI: 10.1016/0006-8993(74)90449-1  0.677
1975 Zivkovic B, Guidotti A, Costa E. The regulation of the kinetic state of striatal tyrosine hydroxylase and the role of postsynaptic dopamine receptors. Brain Research. 92: 516-21. PMID 240486 DOI: 10.1016/0006-8993(75)90340-6  0.673
1975 Mao CC, Guidotti A, Costa E. Evidence for an involvement of GABA in the mediation of the cerebellar cGMP decrease and the anticonvulsant action diazepam. Naunyn-Schmiedeberg's Archives of Pharmacology. 289: 369-78. PMID 240134 DOI: 10.1007/BF00508411  0.701
1975 Zivkovic B, Guidotti A, Costa E. Stereospecificity of dopamine receptors involved in the regulation of the kinetic state of tyrosine hydroxylase in striatum and nucleus accumbens. The Journal of Pharmacy and Pharmacology. 27: 359-60. PMID 239138 DOI: 10.1111/j.2042-7158.1975.tb09455.x  0.669
1975 Hanbauer I, Guidotti A, Costa E. Dexamethasone induces tyrosine hydroxylase in sympathetic ganglia but not in adrenal medulla. Brain Research. 85: 527-31. PMID 236074 DOI: 10.1016/0006-8993(75)90826-4  0.668
1975 Guidotti A, Biggio G, Costa E. 3-Acetylpyridine: a tool to inhibit the tremor and the increase of cGMP content in cerebellar cortex elicited by harmaline. Brain Research. 96: 201-5. PMID 169960  0.663
1975 Costa E, Guidotti A, Mao CC, Suria A. New concepts on the mechanism of action of benzodiazepines. Life Sciences. 17: 167-85. PMID 169445 DOI: 10.1016/0024-3205(75)90501-9  0.647
1975 Mao CC, Guidotti A, Costa E. Inhibition by diazepam of the tremor and the increase of cerebellar cGMD content elicited by harmaline. Brain Research. 83: 516-9. PMID 163118 DOI: 10.1016/0006-8993(75)90846-X  0.666
1975 Carenzi A, Cheney DL, Costa E, Guidotti A, Racagni G. Action of opiates, antipsychotics, amphetamine and apomorphine on dopamine receptors in rat striatum: in vivo changes of 3',5'-cyclic AMP content and acetylcholine turnover rate. Neuropharmacology. 14: 927-39. PMID 3748 DOI: 10.1016/0028-3908(75)90047-7  0.311
1974 Guidotti A, Costa E. Association between increase in cyclic AMP and subsequent induction of tyrosine hydroxylase in rat adrenal medulla. Experiments with swimming stress. Naunyn-Schmiedeberg's Archives of Pharmacology. 282: 217-21. PMID 4152787 DOI: 10.1007/BF00499036  0.654
1974 Costa E, Guidotti A, Hanbauer I. Do cyclic nucleotides promote the trans-synaptic induction of tyrosine hydroxylase? Life Sciences. 14: 1169-88. PMID 4150901 DOI: 10.1016/0024-3205(74)90425-1  0.662
1973 Zivkovic B, Guidotti A, Costa E. Increase of tryptophan hydroxylase activity elicited by reserpine. Brain Research. 57: 522-6. PMID 4722068 DOI: 10.1016/0006-8993(73)90160-1  0.654
1973 Guidotti A, Costa E. Involvement of Adenosine 3',5'-Monophosphate in the Activation of Tyrosine Hydroxylase Elicited by Drugs Science. 179: 902-904. PMID 4405771 DOI: 10.1126/Science.179.4076.902  0.693
1973 Guidotti A, Zivkovic B, Pfeiffer R, Costa E. Involvement of 3',5'-cyclic adenosine monophosphate in the increase of tyrosine hydroxylase activity elicited by cold exposure. Naunyn-Schmiedeberg's Archives of Pharmacology. 278: 195-206. PMID 4146165 DOI: 10.1007/BF00500650  0.653
1973 Guidotti A, Mao C, Costa E. Trans-synaptic regulation of tyrosine hydroxylase in adrenal medulla: Possible role of cyclic nucleotides Life Sciences. 13: lxiii-lxv. DOI: 10.1016/0024-3205(73)90298-1  0.668
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