Iain Clarke - Publications

Affiliations: 
Monash University, Caulfield East, Victoria, Australia 

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Year Citation  Score
2023 Simpson EM, Clarke IJ, Scott CJ, Stephen CP, Rao A, Gunn AJ. The GLP-1 agonist, Exendin-4, stimulates LH secretion in female sheep. The Journal of Endocrinology. PMID 37466202 DOI: 10.1530/JOE-23-0105  0.38
2022 Clarke IJ, Reed CB, Burke CR, Li Q, Meier S. Kiss1 expression in the hypothalamic arcuate nucleus is lower in dairy cows of reduced fertility. Biology of Reproduction. PMID 34982141 DOI: 10.1093/biolre/ioab240  0.316
2021 Arbabi L, Li Q, Henry BA, Clarke IJ. Glucagon-like peptide-1 control of GnRH secretion in female sheep. The Journal of Endocrinology. PMID 33446613 DOI: 10.1530/JOE-20-0335  0.399
2018 Smith JT, Roseweir A, Millar M, Clarke I, Millar RP. Stimulation of growth hormone by kisspeptin antagonists in ewes. The Journal of Endocrinology. PMID 29549187 DOI: 10.1530/Joe-18-0074  0.451
2017 Clarke IJ, Li Q, Henry BA, Millar RP. Continuous Kisspeptin restores Luteinizing Hormone pulsatility following cessation by a Neurokinin B antagonist in female sheep. Endocrinology. PMID 29126131 DOI: 10.1210/en.2017-00737  0.374
2017 Foradori CD, Whitlock BK, Daniel JA, Zimmerman AD, Jones MA, Read CC, Steele BP, Smith JT, Clarke IJ, Elsasser TH, Keisler DH, Sartin JL. Kisspeptin Stimulates Growth Hormone Release by Utilizing Neuropeptide Y Pathways and Is Dependent on the Presence of Ghrelin in the Ewe. Endocrinology. 158: 3526-3539. PMID 28977590 DOI: 10.1210/En.2017-00303  0.356
2017 Pouchain Ribeiro Neto R, Clarke IJ, Conductier G. Alteration in the relationship between tanycytes and gonadotropin releasing hormone (GnRH) neurosecretory terminals following long-term metabolic manipulation in the sheep. Journal of Neuroendocrinology. PMID 28722251 DOI: 10.1111/jne.12509  0.305
2017 George JT, Hendrikse M, Veldhuis JD, Clarke IJ, Anderson RA, Millar RP. Effect of gonadotropin inhibitory hormone (GnIH) on luteinizing hormone secretion in humans. Clinical Endocrinology. PMID 28186349 DOI: 10.1111/cen.13308  0.305
2016 Allen-Worthington K, Xie J, Brown JL, Edmunson AM, Dowling A, Navratil AM, Scavelli K, Yoon H, Kim DG, Bynoe MS, Clarke I, Roberson MS. The F0F1 ATP synthase complex localizes to membrane rafts in gonadotrope cells. Molecular Endocrinology (Baltimore, Md.). me20151324. PMID 27482602 DOI: 10.1210/Me.2015-1324  0.351
2015 Fraser GL, Hoveyda HR, Clarke IJ, Ramaswamy S, Plant TM, Rose C, Millar RP. The NK3 Receptor Antagonist ESN364 Interrupts Pulsatile LH Secretion and Moderates Levels of Ovarian Hormones Throughout the Menstrual Cycle. Endocrinology. 156: 4214-25. PMID 26305889 DOI: 10.1210/En.2015-1409  0.357
2015 Ezzat A, Pereira A, Clarke IJ. Kisspeptin is a component of the pulse generator for GnRH secretion in female sheep but not the pulse generator. Endocrinology. 156: 1828-37. PMID 25710282 DOI: 10.1210/en.2014-1756  0.341
2014 Clarke IJ, Parkington HC. Gonadotropin inhibitory hormone (GnIH) as a regulator of gonadotropes. Molecular and Cellular Endocrinology. 385: 36-44. PMID 23994028 DOI: 10.1016/j.mce.2013.08.017  0.312
2012 Smith JT, Young IR, Veldhuis JD, Clarke IJ. Gonadotropin-inhibitory hormone (GnIH) secretion into the ovine hypophyseal portal system. Endocrinology. 153: 3368-75. PMID 22549225 DOI: 10.1210/En.2012-1088  0.386
2012 Li Q, Roa A, Clarke IJ, Smith JT. Seasonal variation in the gonadotropin-releasing hormone response to kisspeptin in sheep: possible kisspeptin regulation of the kisspeptin receptor. Neuroendocrinology. 96: 212-21. PMID 22343304 DOI: 10.1159/000335998  0.336
2012 Engler D, Liu JP, Clarke IJ, Funder JW. Corticotropin-release inhibitory factor Evidence for dual stimulatory and inhibitory hypothalamic regulation over adrenocorticotropin secretion and biosynthesis. Trends in Endocrinology and Metabolism: Tem. 5: 272-83. PMID 18407219 DOI: 10.1016/1043-2760(94)P3202-I  0.326
2011 Li Q, Rao A, Pereira A, Clarke IJ, Smith JT. Kisspeptin cells in the ovine arcuate nucleus express prolactin receptor but not melatonin receptor. Journal of Neuroendocrinology. 23: 871-82. PMID 21793946 DOI: 10.1111/J.1365-2826.2011.02195.X  0.38
2011 Szymanski LA, Schneider JE, Satragno A, Dunshea FR, Clarke IJ. Mesenteric infusion of a volatile fatty acid prevents body weight loss and transiently restores luteinising hormone pulse frequency in ovariectomised, food-restricted ewes. Journal of Neuroendocrinology. 23: 699-710. PMID 21668532 DOI: 10.1111/j.1365-2826.2011.02173.x  0.563
2011 Smith JT, Li Q, Yap KS, Shahab M, Roseweir AK, Millar RP, Clarke IJ. Kisspeptin is essential for the full preovulatory LH surge and stimulates GnRH release from the isolated ovine median eminence. Endocrinology. 152: 1001-12. PMID 21239443 DOI: 10.1210/En.2010-1225  0.313
2011 Sari IP, Jacobi J, Rao A, Clarke I. Gonadotropin inhibitory hormone (GnIH) prevents the ‘priming’ effect of estradiol-17β Indonesian Journal of Pharmacy. 166-173. DOI: 10.14499/Indonesianjpharm0Iss0Pp166-173  0.434
2010 Smith JT, Shahab M, Pereira A, Pau KY, Clarke IJ. Hypothalamic expression of KISS1 and gonadotropin inhibitory hormone genes during the menstrual cycle of a non-human primate. Biology of Reproduction. 83: 568-77. PMID 20574054 DOI: 10.1095/Biolreprod.110.085407  0.316
2010 Smith JT, Clarke IJ. Gonadotropin inhibitory hormone function in mammals. Trends in Endocrinology and Metabolism: Tem. 21: 255-60. PMID 20060314 DOI: 10.1016/J.Tem.2009.11.010  0.321
2010 Henry BA, Blache D, Dunshea FR, Clarke IJ. Altered "set-point" of the hypothalamus determines effects of cortisol on food intake, adiposity, and metabolic substrates in sheep. Domestic Animal Endocrinology. 38: 46-56. PMID 19733031 DOI: 10.1016/j.domaniend.2009.07.006  0.309
2009 Sari IP, Rao A, Smith JT, Tilbrook AJ, Clarke IJ. Effect of RF-amide-related peptide-3 on luteinizing hormone and follicle-stimulating hormone synthesis and secretion in ovine pituitary gonadotropes. Endocrinology. 150: 5549-56. PMID 19808777 DOI: 10.1210/En.2009-0775  0.339
2009 Smith JT, Saleh SN, Clarke IJ. Seasonal and cyclical change in the luteinizing hormone response to kisspeptin in the ewe. Neuroendocrinology. 90: 283-91. PMID 19590160 DOI: 10.1159/000227806  0.384
2009 Clarke IJ, Qi Y, Puspita Sari I, Smith JT. Evidence that RF-amide related peptides are inhibitors of reproduction in mammals. Frontiers in Neuroendocrinology. 30: 371-8. PMID 19362107 DOI: 10.1016/J.Yfrne.2009.04.001  0.327
2009 Pierce BN, Clarke IJ, Turner AI, Rivalland ET, Tilbrook AJ. Cortisol disrupts the ability of estradiol-17beta to induce the LH surge in ovariectomized ewes. Domestic Animal Endocrinology. 36: 202-8. PMID 19185443 DOI: 10.1016/j.domaniend.2008.11.003  0.309
2009 Oakley AE, Breen KM, Clarke IJ, Karsch FJ, Wagenmaker ER, Tilbrook AJ. Cortisol reduces gonadotropin-releasing hormone pulse frequency in follicular phase ewes: influence of ovarian steroids. Endocrinology. 150: 341-9. PMID 18801903 DOI: 10.1210/En.2008-0587  0.363
2009 Pierce BN, Stackpole CA, Breen KM, Clarke IJ, Karsch FJ, Rivalland ET, Turner AI, Caddy DJ, Wagenmaker ER, Oakley AE, Tilbrook AJ. Estradiol enables cortisol to act directly upon the pituitary to suppress pituitary responsiveness to GnRH in sheep. Neuroendocrinology. 89: 86-97. PMID 18714145 DOI: 10.1159/000151543  0.417
2009 Barrell GK, Ridgway MJ, Wellby M, Smith JT, Clarke IJ. 521. Effect Of Kisspeptin On Reproductive Function In Seasonally Acyclic Red Deer Hinds Reproduction, Fertility and Development. 21: 120-120. DOI: 10.1071/Srb09Abs521  0.308
2008 Smith JT, Rao A, Pereira A, Caraty A, Millar RP, Clarke IJ. Kisspeptin is present in ovine hypophysial portal blood but does not increase during the preovulatory luteinizing hormone surge: evidence that gonadotropes are not direct targets of kisspeptin in vivo. Endocrinology. 149: 1951-9. PMID 18162520 DOI: 10.1210/En.2007-1425  0.4
2007 Caraty A, Smith JT, Lomet D, Ben Saïd S, Morrissey A, Cognie J, Doughton B, Baril G, Briant C, Clarke IJ. Kisspeptin synchronizes preovulatory surges in cyclical ewes and causes ovulation in seasonally acyclic ewes. Endocrinology. 148: 5258-67. PMID 17702853 DOI: 10.1210/En.2007-0554  0.333
2007 Szymanski LA, Schneider JE, Friedman MI, Ji H, Kurose Y, Blache D, Rao A, Dunshea FR, Clarke IJ. Changes in insulin, glucose and ketone bodies, but not leptin or body fat content precede restoration of luteinising hormone secretion in ewes. Journal of Neuroendocrinology. 19: 449-60. PMID 17504439 DOI: 10.1111/j.1365-2826.2007.01551.x  0.539
2007 Pierce B, Clarke I, Breen K, Karsch F, Rivalland E, Caddy D, Tilbrook A. ESTRADIOL ENABLES THE DIRECT PITUITARY ACTIONS OF CORTISOL TO SUPPRESS GONADOTROPIN-RELEASING HORMONE (GnRH)-INDUCED LH SECRETION IN OVARIECTOMIZED HYPOTHALAMO-PITUITARY DISCONNECTED (HPD) EWES DURING THE BREEDING SEASON Biology of Reproduction. 77: 184-184. DOI: 10.1093/Biolreprod/77.S1.184  0.477
2006 Estrada KM, Clay CM, Pompolo S, Smith JT, Clarke IJ. Elevated KiSS-1 expression in the arcuate nucleus prior to the cyclic preovulatory gonadotrophin-releasing hormone/lutenising hormone surge in the ewe suggests a stimulatory role for kisspeptin in oestrogen-positive feedback. Journal of Neuroendocrinology. 18: 806-9. PMID 16965299 DOI: 10.1111/J.1365-2826.2006.01485.X  0.35
2006 Stackpole CA, Clarke IJ, Breen KM, Turner AI, Karsch FJ, Tilbrook AJ. Sex difference in the suppressive effect of cortisol on pulsatile secretion of luteinizing hormone in sheep. Endocrinology. 147: 5921-31. PMID 16959831 DOI: 10.1210/En.2006-0667  0.407
2006 Iqbal J, Kurose Y, Canny B, Clarke IJ. Effects of central infusion of ghrelin on food intake and plasma levels of growth hormone, luteinizing hormone, prolactin, and cortisol secretion in sheep. Endocrinology. 147: 510-9. PMID 16210361 DOI: 10.1210/en.2005-1048  0.332
2006 Clarke IJ, Scott CJ, Pereira A, Pompolo S. The role of noradrenaline in the generation of the preovulatory LH surge in the ewe. Domestic Animal Endocrinology. 30: 260-75. PMID 16139986 DOI: 10.1016/j.domaniend.2005.07.006  0.339
2005 Clarke IJ, Pompolo S. Synthesis and secretion of GnRH. Animal Reproduction Science. 88: 29-55. PMID 15993013 DOI: 10.1016/j.anireprosci.2005.05.003  0.309
2005 Kurose Y, Iqbal J, Rao A, Murata Y, Hasegawa Y, Terashima Y, Kojima M, Kangawa K, Clarke IJ. Changes in expression of the genes for the leptin receptor and the growth hormone-releasing peptide/ghrelin receptor in the hypothalamic arcuate nucleus with long-term manipulation of adiposity by dietary means. Journal of Neuroendocrinology. 17: 331-40. PMID 15929739 DOI: 10.1111/j.1365-2826.2005.01318.x  0.302
2005 Clarke IJ, Tobin VA, Pompolo S, Pereira A. Effects of changing gonadotropin-releasing hormone pulse frequency and estrogen treatment on levels of estradiol receptor-alpha and induction of Fos and phosphorylated cyclic adenosine monophosphate response element binding protein in pituitary gonadotropes: studies in hypothalamo-pituitary disconnected ewes. Endocrinology. 146: 1128-37. PMID 15564326 DOI: 10.1210/en.2004-0980  0.316
2005 Stackpole CA, Clarke IJ, Turner AI, Tilbrook AJ. 276. Sex difference in the effect of cortisol on the LH response of the pituitary to exogenous GnRH in hypothalamo-pituitary disconnected gonadectomised sheep Reproduction, Fertility and Development. 17: 114. DOI: 10.1071/SRB05ABS276  0.408
2004 Scott CJ, Clarke IJ, Rao A, Tilbrook AJ. Sex differences in the distribution and abundance of androgen receptor mRNA-containing cells in the preoptic area and hypothalamus of the ram and ewe. Journal of Neuroendocrinology. 16: 956-63. PMID 15667450 DOI: 10.1111/j.1365-2826.2005.01261.x  0.367
2004 Henry BA, Goding JW, Tilbrook AJ, Dunshea FR, Blache D, Clarke IJ. Leptin-mediated effects of undernutrition or fasting on luteinizing hormone and growth hormone secretion in ovariectomized ewes depend on the duration of metabolic perturbation. Journal of Neuroendocrinology. 16: 244-55. PMID 15049855 DOI: 10.1111/j.0953-8194.2004.01157.x  0.351
2004 Breen KM, Stackpole CA, Clarke IJ, Pytiak AV, Tilbrook AJ, Wagenmaker ER, Young EA, Karsch FJ. Does the type II glucocorticoid receptor mediate cortisol-induced suppression in pituitary responsiveness to gonadotropin-releasing hormone? Endocrinology. 145: 2739-46. PMID 15033919 DOI: 10.1210/En.2004-0123  0.365
2003 Estrada KM, Pompolo S, Morris MJ, Tilbrook AJ, Clarke IJ. Neuropeptide Y (NPY) delays the oestrogen-induced luteinizing hormone (LH) surge in the ovariectomized ewe: further evidence that NPY has a predominant negative effect on LH secretion in the ewe. Journal of Neuroendocrinology. 15: 1011-20. PMID 14622430  0.338
2003 Stackpole CA, Turner AI, Clarke IJ, Lambert GW, Tilbrook AJ. Seasonal differences in the effect of isolation and restraint stress on the luteinizing hormone response to gonadotropin-releasing hormone in hypothalamopituitary disconnected, gonadectomized rams and ewes. Biology of Reproduction. 69: 1158-64. PMID 12773406 DOI: 10.1095/biolreprod.103.016428  0.306
2002 Veldhuis JD, Fletcher TP, Gatford KL, Egan AR, Clarke IJ. Hypophyseal-portal somatostatin (SRIH) and jugular venous growth hormone secretion in the conscious unrestrained ewe. Neuroendocrinology. 75: 83-91. PMID 11867936  0.308
2001 Tobin VA, Pompolo S, Clarke IJ. The percentage of pituitary gonadotropes with immunoreactive oestradiol receptors increases in the follicular phase of the ovine oestrous cycle. Journal of Neuroendocrinology. 13: 846-54. PMID 11679053  0.317
2001 Henry BA, Rao A, Tilbrook AJ, Clarke IJ. Chronic food-restriction alters the expression of somatostatin and growth hormone-releasing hormone in the ovariectomised ewe. The Journal of Endocrinology. 170: R1-5. PMID 11431163  0.3
2001 Turner AI, Tilbrook AJ, Clarke IJ, Scott CJ. Progesterone and testosterone in combination act in the hypothalamus of castrated rams to regulate the secretion of LH. The Journal of Endocrinology. 169: 291-8. PMID 11312146 DOI: 10.1677/joe.0.1690291  0.367
2001 Anderson ST, Walsh JP, Tillet Y, Clarke IJ, Curlewis JD. Dopaminergic input to the ventromedial hypothalamus facilitates the oestrogen-induced luteinizing hormone surge in ewes. Neuroendocrinology. 73: 91-101. PMID 11244296 DOI: 10.1159/000054625  0.344
2001 Tilbrook AJ, Clarke IJ. Negative feedback regulation of the secretion and actions of gonadotropin-releasing hormone in males. Biology of Reproduction. 64: 735-42. PMID 11207186  0.329
2001 Tilbrook AJ, de Kretser DM, Clarke IJ. Influence of the degree of stimulation of the pituitary by gonadotropin-releasing hormone on the action of inhibin and testosterone to suppress the secretion of the gonadotropins in rams. Biology of Reproduction. 64: 473-81. PMID 11159349  0.399
2001 Henry BA, Goding JW, Tilbrook AJ, Dunshea FR, Clarke IJ. Intracerebroventricular infusion of leptin elevates the secretion of luteinising hormone without affecting food intake in long-term food-restricted sheep, but increases growth hormone irrespective of bodyweight. The Journal of Endocrinology. 168: 67-77. PMID 11139771  0.307
2000 Whitley JC, Giraud AS, Mahoney AO, Clarke IJ, Shulkes A. Tissue-specific regulation of gastrin-releasing peptide synthesis, storage and secretion by oestrogen and progesterone. The Journal of Endocrinology. 166: 649-58. PMID 10974658 DOI: 10.1677/JOE.0.1660649  0.317
1999 Tilbrook AJ, Canny BJ, Stewart BJ, Serapiglia MD, Clarke IJ. Central administration of corticotrophin releasing hormone but not arginine vasopressin stimulates the secretion of luteinizing hormone in rams in the presence and absence of testosterone. The Journal of Endocrinology. 162: 301-11. PMID 10425469 DOI: 10.1677/joe.0.1620301  0.518
1999 Tilbrook AJ, de Kretser DM, Clarke IJ. Changes in the suppressive effects of recombinant inhibin A on FSH secretion in ram lambs during sexual maturation: evidence for alterations in the clearance rate of inhibin. The Journal of Endocrinology. 161: 219-29. PMID 10320819 DOI: 10.1677/JOE.0.1610219  0.316
1999 Hudson NL, O'Connell AR, Shaw L, Clarke IJ, McNatty KP. Effect of exogenous FSH on ovulation rate in homozygous carriers or noncarriers of the Booroola FecB gene after hypothalamic-pituitary disconnection or after treatment with a GnRH agonist. Domestic Animal Endocrinology. 16: 69-80. PMID 10081664 DOI: 10.1016/S0739-7240(98)00045-9  0.354
1999 Tilbrook A, Canny B, Serapiglia, Ambrose T, Clarke I. Suppression of the secretion of luteinizing hormone due to isolation/restraint stress in gonadectomised rams and ewes is influenced by sex steroids. Journal of Endocrinology. 160: 469-481. PMID 10076193 DOI: 10.1677/Joe.0.1600469  0.438
1999 Roh S, Clarke IJ, Xu R, Goding JW, Loneragan K, Chen C. The in vitro effect of leptin on basal and growth hormone-releasing hormone-stimulated growth hormone secretion from the ovine pituitary gland. Neuroendocrinology. 68: 361-4. PMID 9873199 DOI: 10.1159/000054385  0.317
1999 Tilbrook AJ, de Kretser DM, Clarke IJ. Seasonal changes in the negative feedback regulation of the secretion of the gonadotrophins by testosterone and inhibin in rams. The Journal of Endocrinology. 160: 155-67. PMID 9854187 DOI: 10.1677/JOE.0.1600155  0.333
1998 Gatford KL, Egan AR, Clarke IJ, Owens PC. Sexual dimorphism of the somatotrophic axis Journal of Endocrinology. 157: 373-389. PMID 9691971 DOI: 10.1677/joe.0.1570373  0.347
1998 Chen C, Pullar M, Loneragan K, Zhang J, Clarke IJ. Effect of growth hormone-releasing peptide-2 (GHRP-2) and GH-releasing hormone (GHRH) on the the cAMP levels and GH release from cultured acromegalic tumours. Journal of Neuroendocrinology. 10: 473-80. PMID 9688350 DOI: 10.1046/j.1365-2826.1998.00233.x  0.319
1998 Schwartz J, Van de Pavert S, Clarke I, Rao A, Ray D, Vrana K. Paracrine interactions within the pituitary gland. Annals of the New York Academy of Sciences. 839: 239-43. PMID 9629159 DOI: 10.1111/J.1749-6632.1998.Tb10767.X  0.321
1997 Lew RA, Cowley M, Clarke IJ, Smith AI. Peptidases that degrade gonadotropin-releasing hormone: influence on LH secretion in the ewe. Journal of Neuroendocrinology. 9: 707-12. PMID 9355038 DOI: 10.1046/j.1365-2826.1997.00628.x  0.323
1997 Thomas SG, Clarke IJ. The positive feedback action of estrogen mobilizes LH-containing, but not FSH-containing secretory granules in ovine gonadotropes. Endocrinology. 138: 1347-50. PMID 9048645 DOI: 10.1210/ENDO.138.3.5104  0.331
1996 Fletcher TP, Thomas GB, Clarke IJ. Growth hormone-releasing hormone and somatostatin concentrations in the hypophysial portal blood of conscious sheep during the infusion of growth hormone-releasing peptide-6. Domestic Animal Endocrinology. 13: 251-8. PMID 8738866 DOI: 10.1016/0739-7240(96)00017-3  0.395
1996 Klein R, Robertson DM, Clarke IJ. Studies in sheep examining plasma follistatin elevations due to frequent blood sampling or surgery. Reproduction, Fertility, and Development. 8: 273-7. PMID 8726866 DOI: 10.1071/RD9960273  0.321
1996 Wu D, Chen C, Zhang J, Bowers CY, Clarke IJ. The effects of GH-releasing peptide-6 (GHRP-6) and GHRP-2 on intracellular adenosine 3',5'-monophosphate (cAMP) levels and GH secretion in ovine and rat somatotrophs. The Journal of Endocrinology. 148: 197-205. PMID 8699133 DOI: 10.1677/JOE.0.1480197  0.3
1996 Mercer JE, Phillips DJ, Clarke IJ. Short-term regulation of gonadotropin subunit mRNA levels by estrogen: studies in the hypothalamo-pituitary intact and hypothalamo-pituitary disconnected ewe. Journal of Neuroendocrinology. 5: 591-6. PMID 8680429 DOI: 10.1111/j.1365-2826.1993.tb00526.x  0.349
1996 Wright PJ, Galloway DB, Clarke IJ. Gonadotrophin secretion in ewes with bilateral gonadal hypoplasia. Australian Veterinary Journal. 73: 157-8. PMID 8660234 DOI: 10.1111/J.1751-0813.1996.TB10012.X  0.327
1996 Tilbrook AJ, Clarke IJ, de Kretser DM. Human recombinant follistatin-288 suppresses plasma concentrations of follicle-stimulating hormone but is not a significant regulator of luteinizing hormone in castrated rams. Biology of Reproduction. 53: 1353-8. PMID 8562691 DOI: 10.1095/BIOLREPROD53.6.1353  0.32
1995 Clarke IJ. Evidence that the switch from negative to positive feedback at the level of the pituitary gland is an important timing event for the onset of the preovulatory surge in LH in the ewe. The Journal of Endocrinology. 145: 271-82. PMID 7616160 DOI: 10.1677/JOE.0.1450271  0.385
1994 Fletcher TP, Clarke IJ. Effects of hypothyroidism on the growth hormone axis in sheep. The Journal of Endocrinology. 140: 495-502. PMID 8182377 DOI: 10.1677/JOE.0.1400495  0.379
1994 Liu JP, Clarke IJ, Funder JW, Engler D. Studies of the secretion of corticotropin-releasing factor and arginine vasopressin into the hypophysial-portal circulation of the conscious sheep. II. The central noradrenergic and neuropeptide Y pathways cause immediate and prolonged hypothalamic-pituitary-adrenal activation. Potential involvement in the pseudo-Cushing's syndrome of endogenous depression and anorexia nervosa. The Journal of Clinical Investigation. 93: 1439-50. PMID 8163648 DOI: 10.1172/JCI117121  0.323
1994 Fletcher TP, Thomas GB, Willoughby JO, Clarke IJ. Constitutive growth hormone secretion in sheep after hypothalamopituitary disconnection and the direct in vivo pituitary effect of growth hormone releasing peptide 6. Neuroendocrinology. 60: 76-86. PMID 8090285 DOI: 10.1159/000126722  0.37
1994 Wu D, Chen C, Zhang J, Katoh K, Clarke I. Effects in vitro of new growth hormone releasing peptide (GHRP-1) on growth hormone secretion from ovine pituitary cells in primary culture Journal of Neuroendocrinology. 6: 185-190. PMID 8049717 DOI: 10.1111/J.1365-2826.1994.Tb00571.X  0.412
1994 Thomas GB, Scott CJ, Cummins JT, Clarke IJ. Adrenergic regulation of growt hormone secretion in the ewe Domestic Animal Endocrinology. 11: 187-195. PMID 8045100 DOI: 10.1016/0739-7240(94)90026-4  0.369
1994 Clarke IJ, Fletcher TP, Pomares CC, Holmes JH, Dunshea F, Thomas GB, Tilbrook AJ, Walton PE, Galloway DB. Effect of high-protein feed supplements on concentrations of growth hormone (GH), insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 in plasma and on the amounts of GH and messenger RNA for GH in the pituitary glands of adult rams. The Journal of Endocrinology. 138: 421-7. PMID 7506288 DOI: 10.1677/JOE.0.1380421  0.304
1993 Tilbrook AJ, Galloway DB, Williams AH, Clarke IJ. Treatment of young rams with an agonist of GnRH delays reproductive development. Hormones and Behavior. 27: 5-28. PMID 8440517 DOI: 10.1006/hbeh.1993.1002  0.316
1993 Clarke IJ. Variable patterns of gonadotropin-releasing hormone secretion during the estrogen-induced luteinizing hormone surge in ovariectomized ewes. Endocrinology. 133: 1624-32. PMID 8404603 DOI: 10.1210/ENDO.133.4.8404603  0.394
1993 McNatty KP, Hudson NL, Lun S, Heath DA, Shaw L, Condell L, Phillips DJ, Clarke IJ. Gonadotrophin-releasing hormone and the control of ovulation rate by the FecB gene in Booroola ewes. Journal of Reproduction and Fertility. 98: 97-105. PMID 8345485 DOI: 10.1530/JRF.0.0980097  0.353
1993 Tilbrook AJ, de Kretser DM, Clarke IJ. Human recombinant inhibin A and testosterone act directly at the pituitary to suppress plasma concentrations of FSH in castrated rams. The Journal of Endocrinology. 138: 181-9. PMID 8228726 DOI: 10.1677/JOE.0.1380181  0.326
1993 Tilbrook AJ, De Kretser DM, Clarke IJ. Human recombinant inhibin A suppresses plasma follicle-stimulating hormone to intact levels but has no effect on luteinizing hormone in castrated rams. Biology of Reproduction. 49: 779-88. PMID 8218642 DOI: 10.1095/BIOLREPROD49.4.779  0.321
1993 Clarke I, Jessop D, Millar R, Morris M, Bloom S, Lightman S, Coen CW, Lew R, Smith I. Many peptides that are present in the external zone of the median eminence are not secreted into the hypophysial portal blood of sheep. Neuroendocrinology. 57: 765-75. PMID 7692337 DOI: 10.1159/000126435  0.314
1992 Tilbrook AJ, Johnson RJ, Eason PJ, Walsh JD, Trigg TE, Clarke IJ. Short-term reduction in egg production in laying hens treated with an agonist of GnRH. British Poultry Science. 33: 621-38. PMID 1643525 DOI: 10.1080/00071669208417501  0.309
1992 Galloway D, Wright P, Kretser Dd, Clarke I. An outbreak of gonadal hypoplasia in a sheep flock: clinical, pathological and endocrinological features, and aetiological studies Veterinary Record. 131: 506-512. PMID 1300677 DOI: 10.1136/Vr.131.22.506  0.348
1991 Phillips DJ, Cummins JT, Clarke IJ. Effects of modifying gonadotrophin-releasing hormone input before and after the oestrogen-induced LH surge in ovariectomized ewes with hypothalamo-pituitary disconnection. The Journal of Endocrinology. 127: 223-33. PMID 2250148 DOI: 10.1677/JOE.0.1270223  0.373
1991 Tilbrook AJ, de Kretser DM, Cummins JT, Clarke IJ. The negative feedback effects of testicular steroids are predominantly at the hypothalamus in the ram. Endocrinology. 129: 3080-92. PMID 1954890 DOI: 10.1210/ENDO-129-6-3080  0.372
1991 Robertson DM, Foulds LM, Fry RC, Cummins JT, Clarke I. Circulating half-lives of follicle-stimulating hormone and luteinizing hormone in pituitary extracts and isoform fractions of ovariectomized and intact ewes. Endocrinology. 129: 1805-13. PMID 1915069 DOI: 10.1210/endo-129-4-1805  0.351
1991 McNatty KP, Hudson NL, Shaw L, Condell LA, Ball K, Seah SL, Clarke IJ. GnRH-induced gonadotrophin secretion in ovariectomized Booroola ewes with hypothalamic-pituitary disconnection. Journal of Reproduction and Fertility. 91: 583-92. PMID 1901606 DOI: 10.1530/JRF.0.0910583  0.409
1991 Thomas GB, Cummins JT, Francis H, Sudbury AW, McCloud PI, Clarke IJ. Effect of restricted feeding on the relationship between hypophysial portal concentrations of growth hormone (GH)-releasing factor and somatostatin, and jugular concentrations of GH in ovariectomized ewes. Endocrinology. 128: 1151-8. PMID 1671214 DOI: 10.1210/endo-128-2-1151  0.368
1991 Liu JP, Clarke IJ, Funder JW, Engler D. Evidence that the central noradrenergic and adrenergic pathways activate the hypothalamic-pituitary-adrenal axis in the sheep. Endocrinology. 129: 200-9. PMID 1647297 DOI: 10.1210/ENDO-129-1-200  0.336
1990 Clarke IJ, Foulds LM, Hayward S, Cummins JT, Robertson DM. Analysis of the ratio of biological to immunological LH secreted during the oestrogen-induced LH surge in the ewe. The Journal of Endocrinology. 127: 217-22. PMID 2250147 DOI: 10.1677/JOE.0.1270217  0.339
1990 Clarke IJ, Horton RJ, Doughton BW. Investigation of the mechanism by which insulin-induced hypoglycemia decreases luteinizing hormone secretion in ovariectomized ewes. Endocrinology. 127: 1470-6. PMID 2201538 DOI: 10.1210/ENDO-127-3-1470  0.314
1990 Phillips DJ, Clarke IJ. Effects of the synthetic glucocorticoid dexamethasone on reproductive function in the ewe. The Journal of Endocrinology. 126: 289-95. PMID 2119414 DOI: 10.1677/JOE.0.1260289  0.363
1990 Antolovich GC, Clarke IJ, McMillen IC, Perry RA, Robinson PM, Silver M, Young R. Hypothalamo-pituitary disconnection in the fetal sheep. Neuroendocrinology. 51: 1-9. PMID 2106081 DOI: 10.1159/000125308  0.318
1990 Findlay JK, Clarke IJ, Robertson DM. Inhibin concentrations in ovarian and jugular venous plasma and the relationship of inhibin with follicle-stimulating hormone and luteinizing hormone during the ovine estrous cycle. Endocrinology. 126: 528-35. PMID 2104590 DOI: 10.1210/endo-126-1-528  0.325
1990 Frohman LA, Downs TR, Kelijman M, Clarke IJ, Thomas G. Somatostatin secretion and action in the regulation of growth hormone secretion. Metabolism: Clinical and Experimental. 39: 43-5. PMID 1976219 DOI: 10.1016/0026-0495(90)90208-T  0.362
1990 Engler D, Pham T, Liu JP, Fullerton MJ, Clarke IJ, Funder JW. Studies of the regulation of the hypothalamic-pituitary-adrenal axis in sheep with hypothalamic-pituitary disconnection. II. Evidence for in vivo ultradian hypersecretion of proopiomelanocortin peptides by the isolated anterior and intermediate pituitary. Endocrinology. 127: 1956-66. PMID 1976094 DOI: 10.1210/ENDO-127-4-1956  0.315
1990 Frohman LA, Downs TR, Clarke IJ, Thomas GB. Measurement of growth hormone-releasing hormone and somatostatin in hypothalamic-portal plasma of unanesthetized sheep. Spontaneous secretion and response to insulin-induced hypoglycemia. The Journal of Clinical Investigation. 86: 17-24. PMID 1973173 DOI: 10.1172/JCI114681  0.378
1989 Thomas GB, Cummins JT, Doughton BW, Griffin N, Millar RP, Milton RC, Clarke IJ. Gonadotropin-releasing hormone associated peptide (GAP) and putative processed GAP peptides do not release luteinizing hormone or follicle-stimulating hormone or inhibit prolactin secretion in the sheep. Neuroendocrinology. 48: 342-50. PMID 3145468 DOI: 10.1159/000125033  0.398
1989 Handelsman DJ, Cummins JT, Clarke IJ. Pharmacodynamics of gonadotropin-releasing hormone. 1. Effects of gonadotropin-releasing hormone pulse contour on pituitary luteinizing hormone secretion in vivo in sheep. Neuroendocrinology. 48: 432-8. PMID 3062484 DOI: 10.1159/000125045  0.383
1989 Engler D, Pham T, Fullerton MJ, Funder JW, Clarke IJ. Studies of the regulation of the hypothalamic-pituitary-adrenal axis in sheep with hypothalamic-pituitary disconnection. I. Effect of an audiovisual stimulus and insulin-induced hypoglycemia. Neuroendocrinology. 48: 551-60. PMID 2854224 DOI: 10.1159/000125062  0.314
1989 Clarke I. Hypothalamic inhibitor of GnRH action Reproduction, Fertility and Development. 1: 273-274. PMID 2682808 DOI: 10.1071/Rd9890273  0.333
1989 Clarke IJ, Cummins JT, Jenkin M, Phillips DJ. The oestrogen-induced surge of LH requires a 'signal' pattern of gonadotrophin-releasing hormone input to the pituitary gland in the ewe. The Journal of Endocrinology. 122: 127-34. PMID 2671236  0.405
1989 Thomas GB, Cummins JT, Canny BJ, Rundle SE, Griffin N, Katsahambas S, Clarke IJ. The posterior pituitary regulates prolactin, but not adrenocorticotropin or gonadotropin, secretion in the sheep. Endocrinology. 125: 2204-11. PMID 2551641 DOI: 10.1210/ENDO-125-4-2204  0.331
1989 Engler D, Pham T, Fullerton MJ, Ooi G, Funder JW, Clarke IJ. Studies of the secretion of corticotropin-releasing factor and arginine vasopressin into the hypophysial-portal circulation of the conscious sheep. I. Effect of an audiovisual stimulus and insulin-induced hypoglycemia. Neuroendocrinology. 49: 367-81. PMID 2541360 DOI: 10.1159/000125141  0.357
1989 Clarke IJ, Cummins JT, Crowder ME, Nett TM. Long-term negative feedback effects of oestrogen and progesterone on the pituitary gland of the long-term ovariectomized ewe. The Journal of Endocrinology. 120: 207-14. PMID 2538532 DOI: 10.1677/JOE.0.1200207  0.365
1989 Clarke IJ. The GNRH/gonadotropin axis in the ewe, cow and sow. Domestic Animal Endocrinology. 6: 1-14. PMID 2492916 DOI: 10.1016/0739-7240(89)90002-7  0.342
1988 Clarke IJ. Gonadotrophin-releasing hormone secretion (GnRH) in anoestrous ewes and the induction of GnRH surges by oestrogen. The Journal of Endocrinology. 117: 355-60. PMID 3292694 DOI: 10.1677/JOE.0.1170355  0.399
1988 Wright PJ, Clarke IJ. Pulsatile administration of gonadotrophin-releasing hormone stimulates, in oestrogen-treated anaesthetized ovariectomized ewes, a surge release of LH qualitatively and quantitatively different from that induced by oestradiol in conscious ovariectomized ewes. The Journal of Endocrinology. 116: 143-8. PMID 3276807 DOI: 10.1677/JOE.0.1160143  0.43
1988 Mercer JE, Clements JA, Funder JW, Clarke IJ. Luteinizing hormone-beta mRNA levels are regulated primarily by gonadotropin-releasing hormone and not by negative estrogen feedback on the pituitary. Neuroendocrinology. 47: 563-6. PMID 3135509 DOI: 10.1159/000124969  0.33
1988 Thomas GB, Cummins JT, Yao B, Gordon K, Clarke IJ. Release of prolactin is independent of the secretion of thyrotrophin-releasing hormone into hypophysial portal blood of sheep. The Journal of Endocrinology. 117: 115-22. PMID 3128621 DOI: 10.1677/JOE.0.1170115  0.369
1988 Wu FC, Irby DC, Clarke IJ, Cummins JT, de Kretser DM. Effects of gonadotropin-releasing hormone pulse-frequency modulation on luteinizing hormone, follicle-stimulating hormone and testosterone secretion in hypothalamo/pituitary-disconnected rams. Biology of Reproduction. 37: 501-10. PMID 3118979 DOI: 10.1095/BIOLREPROD37.3.501  0.412
1988 Clarke IJ, Cummins JT, Crowder ME, Nett TM. Pituitary receptors for gonadotropin-releasing hormone in relation to changes in pituitary and plasma gonadotropins in ovariectomized hypothalamo/pituitary-disconnected ewes. II. A marked rise in receptor number during the acute feedback effects of estradiol. Biology of Reproduction. 39: 349-54. PMID 2846084 DOI: 10.1095/BIOLREPROD39.2.349  0.385
1988 Thomas GB, Cummins JT, Griffin N, Clarke IJ. Effect and site of action of hypothalamic neuropeptides on prolactin release in sheep. Neuroendocrinology. 48: 252-7. PMID 2460794 DOI: 10.1159/000125019  0.377
1987 Fry RC, Clarke IJ, Cahill LP. Changes in gonadotrophin concentrations are not necessarily involved in ovarian compensation after unilateral ovariectomy in sheep. Journal of Reproduction and Fertility. 79: 45-8. PMID 3820183 DOI: 10.1530/JRF.0.0790045  0.311
1987 Thomas GB, Cummins JT, Cavanagh L, Clarke IJ. Transient increase in prolactin secretion following hypothalamo-pituitary disconnection in ewes during anoestrus and the breeding season. The Journal of Endocrinology. 111: 425-31. PMID 3805968 DOI: 10.1677/JOE.0.1110425  0.398
1987 Horton RJ, Cummins JT, Clarke IJ. Naloxone evokes large-amplitude GnRH pulses in luteal-phase ewes. Journal of Reproduction and Fertility. 81: 277-86. PMID 3312598 DOI: 10.1530/JRF.0.0810277  0.356
1987 Karsch FJ, Cummins JT, Thomas GB, Clarke IJ. Steroid feedback inhibition of pulsatile secretion of gonadotropin-releasing hormone in the ewe. Biology of Reproduction. 36: 1207-18. PMID 3304436 DOI: 10.1095/Biolreprod36.5.1207  0.424
1987 Clarke IJ, Thomas GB, Yao B, Cummins JT. GnRH secretion throughout the ovine estrous cycle. Neuroendocrinology. 46: 82-8. PMID 3302748 DOI: 10.1159/000124800  0.357
1987 Clarke IJ, Cummins JT. Pulsatility of reproductive hormones: physiological basis and clinical implications. Bailliere's Clinical Endocrinology and Metabolism. 1: 1-21. PMID 3297019 DOI: 10.1016/S0950-351X(87)80050-2  0.352
1987 Hurley DM, Clarke IJ, Shelton R, Burger HG. Subcutaneous administration of gonadotropin-releasing hormone: absorption kinetics and gonadotropin responses. The Journal of Clinical Endocrinology and Metabolism. 65: 46-52. PMID 3108305 DOI: 10.1210/JCEM-65-1-46  0.348
1987 Clarke IJ, Cummins JT, Crowder ME, Nett TM. Pituitary receptors for gonadotropin-releasing hormone in relation to changes in pituitary and plasma luteinizing hormone in ovariectomized-hypothalamo pituitary disconnected ewes. I. Effect of changing frequency of gonadotropin-releasing hormone pulses. Biology of Reproduction. 37: 749-54. PMID 2825822 DOI: 10.1095/BIOLREPROD37.4.749  0.423
1987 Clarke I. New Concepts in Gonadotropin-Releasing Hormone Action on the Pituitary Gland Seminars in Reproductive Medicine. 5: 345-352. DOI: 10.1055/S-2007-1021881  0.319
1986 Thomas GB, Cummins JT, Hammond JM, Horton RJ, Clarke IJ. Prolonged secretion of prolactin in response to thyrotrophin-releasing hormone after hypothalamo-pituitary disconnection in the ewe Journal of Endocrinology. 111: 433-438. PMID 3100711 DOI: 10.1677/JOE.0.1110433  0.378
1986 Clarke IJ, Burman KJ, Doughton BW, Cummins JT. Effects of constant infusion of gonadotrophin-releasing hormone in ovariectomized ewes with hypothalamo-pituitary disconnection: further evidence for differential control of LH and FSH secretion and the lack of a priming effect. The Journal of Endocrinology. 111: 43-9. PMID 3097234  0.704
1986 Clarke IJ, Findlay JK, Cummins JT, Ewens WJ. Effects of ovine follicular fluid on plasma LH and FSH secretion in ovariectomized ewes to indicate the site of action of inhibin Journal of Reproduction and Fertility. 77: 575-585. PMID 3090245 DOI: 10.1530/JRF.0.0770575  0.379
1985 Clarke IJ, Cummins JT. Direct pituitary effects of estrogen and progesterone on gonadotropin secretion in the ovariectomized ewe. Neuroendocrinology. 39: 267-74. PMID 6438545 DOI: 10.1159/000123990  0.398
1985 Clarke IJ, Cummins JT. GnRH pulse frequency determines LH pulse amplitude by altering the amount of releasable LH in the pituitary glands of ewes. Journal of Reproduction and Fertility. 73: 425-31. PMID 3921703 DOI: 10.1530/JRF.0.0730425  0.374
1985 Clarke IJ, Cummins JT. Increased gonadotropin-releasing hormone pulse frequency associated with estrogen-induced luteinizing hormone surges in ovariectomized ewes. Endocrinology. 116: 2376-83. PMID 3888609 DOI: 10.1210/ENDO-116-6-2376  0.387
1984 Clarke IJ, Cummins JT, Findlay JK, Burman KJ, Doughton BW. Effects on plasma luteinizing hormone and follicle-stimulating hormone of varying the frequency and amplitude of gonadotropin-releasing hormone pulses in ovariectomized ewes with hypothalamo-pituitary disconnection. Neuroendocrinology. 39: 214-21. PMID 6438544  0.695
1984 Hurley DM, Brian R, Outch K, Stockdale J, Fry A, Hackman C, Clarke I, Burger HG. Induction of ovulation and fertility in amenorrheic women by pulsatile low-dose gonadotropin-releasing hormone. The New England Journal of Medicine. 310: 1069-74. PMID 6424012 DOI: 10.1056/NEJM198404263101702  0.474
1984 Clarke IJ, Wright PJ, Chamley WA, Burman K. Differences in the reproductive endocrine status of ewes in the early post-partum period and during seasonal anoestrus. Journal of Reproduction and Fertility. 70: 591-7. PMID 6422034 DOI: 10.1530/JRF.0.0700591  0.389
1984 Wright PJ, Geytenbeek PE, Clarke IJ, Findlay JK. Induction of plasma LH surges and normal luteal function in acyclic post-partum ewes by the pulsatile administration of LH-RH. Journal of Reproduction and Fertility. 71: 1-6. PMID 6374129 DOI: 10.1530/JRF.0.0710001  0.31
1984 Hurley DH, Brian R, Outch K, Stockdale J, Fry A, Hackman C, Clarke I, Burger HG. Induction of ovulation and fertility in amenorrheic women by pulsatile low-dose gonadotropin-releasing hormone Obstetrical & Gynecological Survey. 39: 589-590. DOI: 10.1097/00006254-198409000-00016  0.362
1983 Clarke IJ. Effects of tamoxifen on concentrations of luteinizing hormone and follicle-stimulating hormone in the plasma of ovariectomized ewes. The Journal of Endocrinology. 99: 23-9. PMID 6415198 DOI: 10.1677/JOE.0.0990023  0.357
1983 Clarke IJ, Doughton BW. Effect of various anaesthetics on resting plasma concentrations of luteinizing hormone, follicle-stimulating hormone and prolactin in ovariectomized ewes. The Journal of Endocrinology. 98: 79-89. PMID 6408219 DOI: 10.1677/JOE.0.0980079  0.344
1983 Clarke IJ, Cummins JT, de Kretser DM. Pituitary gland function after disconnection from direct hypothalamic influences in the sheep. Neuroendocrinology. 36: 376-84. PMID 6406927 DOI: 10.1159/000123484  0.388
1983 Wright PJ, Geytenbeek PE, Clarke IJ, Findlay JK. LH release and luteal function in post-partum acyclic ewes after the pulsatile administration of LH-RH. Journal of Reproduction and Fertility. 67: 257-62. PMID 6339715 DOI: 10.1530/JRF.0.0670257  0.369
1982 Clarke IJ, Mitchelhill K, Zachariah E, Findlay JK, Funder JW. Analysis of androgen action on pituitary gonadotropin and prolactin secretion in ewes. Biology of Reproduction. 26: 777-86. PMID 6807361 DOI: 10.1095/BIOLREPROD26.5.777  0.342
1982 Clarke IJ, Cummins JT. The temporal relationship between gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH) secretion in ovariectomized ewes. Endocrinology. 111: 1737-9. PMID 6751801 DOI: 10.1210/ENDO-111-5-1737  0.364
1982 Clarke IJ, Wynne K, Funder JW, Findlay JK. Effects of 2-hydroxyoestradiol-17 beta on plasma luteinizing hormone, follicle-stimulating hormone and prolactin, and nuclear translocation of pituitary oestrogen receptors in ovariectomized ewes. The Journal of Endocrinology. 95: 19-27. PMID 6290586 DOI: 10.1677/JOE.0.0950019  0.33
1981 Wright PJ, Geytenbeek PE, Clarke IJ, Findlay JK. Evidence for a change in oestradiol negative feedback and LH pulse frequency in post-partum ewes. Journal of Reproduction and Fertility. 61: 97-102. PMID 7452631 DOI: 10.1530/JRF.0.0610097  0.359
1981 Wright PJ, Geytenbeek PE, Clarke IJ, Findlay JK. Pitutary responsiveness to LH-RH, the occurrence of oestradiol- 17 beta-induced LH-positive feedback and the resumption of oestrous cycles in ewes post partum. Journal of Reproduction and Fertility. 60: 171-6. PMID 7001009 DOI: 10.1530/JRF.0.0600171  0.301
1981 Fraser HM, Clarke IJ, McNeilly AS. Effect of oestrogen and an LH-RH agonist on the release of gonadotrophins in ovariectomized ewes deprived of LH-RH. Journal of Reproduction and Fertility. 62: 131-40. PMID 6785428 DOI: 10.1530/JRF.0.0620131  0.37
1981 Brien F, Cumming I, Clarke I, Cocks C. Role of plasma progesterone concentration in early pregnancy of the ewe Australian Journal of Experimental Agriculture. 21: 562-565. DOI: 10.1071/Ea9810562  0.356
1980 Rodgers R, Clarke I, Findlay J, Brown A, Cumming I, Muller B, Walker S. Plasma LH and FSH in ewes that were either fertile or infertile after long-term grazing of oestrogenic pasture. Australian Journal of Biological Sciences. 33: 213-220. PMID 6776942 DOI: 10.1071/Bi9800213  0.444
1978 Clarke IJ, Fraser HM, McNeilly AS. Active immunization of ewes against luteinizing hormone releasing hormone, and its effects on ovulation and gonadotrophin, prolactin and ovarian steroid secretion. The Journal of Endocrinology. 78: 39-47. PMID 355590 DOI: 10.1677/JOE.0.0780039  0.385
1978 Clarke IJ, Scaramuzzi RJ. Release of luteinizing hormone in androgenized ewes after prostaglandin-induced luteolysis or luteinizing hormone releasing hormone. The Journal of Endocrinology. 77: 261-2. PMID 351121 DOI: 10.1677/JOE.0.0770261  0.337
Low-probability matches (unlikely to be authored by this person)
2012 Clarke IJ, Smith JT, Henry BA, Oldfield BJ, Stefanidis A, Millar RP, Sari IP, Chng K, Fabre-Nys C, Caraty A, Ang BT, Chan L, Fraley GS. Gonadotropin-inhibitory hormone is a hypothalamic peptide that provides a molecular switch between reproduction and feeding. Neuroendocrinology. 95: 305-16. PMID 22286004 DOI: 10.1159/000332822  0.3
1991 Tilbrook AJ, de Kretser DM, Clarke IJ. Studies on the testicular source of inhibin and its route of secretion in rams: failure of the Leydig cell to secrete inhibin in response to a human chorionic gonadotrophin/LH stimulus. The Journal of Endocrinology. 130: 107-14. PMID 1880471 DOI: 10.1677/JOE.0.1300107  0.3
1994 Wright PJ, Williams AH, Clarke IJ. Gonadotrophin-releasing hormone administered in continuous low dose can induce ovulation and normal corpora lutea in acyclic post-partum ewes and seasonally anoestrous ewes. Australian Veterinary Journal. 71: 123-5. PMID 8048909 DOI: 10.1111/J.1751-0813.1994.TB03354.X  0.3
1999 Cowley MA, Rao A, Wright PJ, Illing N, Millar RP, Clarke IJ. Evidence for differential regulation of multiple transcripts of the gonadotropin releasing hormone receptor in the ovine pituitary gland; effect of estrogen. Molecular and Cellular Endocrinology. 146: 141-9. PMID 10022772 DOI: 10.1016/S0303-7207(98)00162-2  0.299
1998 Walsh JP, Clarke IJ. Blockade of the oestrogen-induced luteinizing hormone surge in ovariectomized ewes by a highly selective opioid mu-receptor agonist: evidence for site of action. Neuroendocrinology. 67: 164-70. PMID 9630433 DOI: 10.1159/000054311  0.298
1989 Canny BJ, Funder JW, Clarke IJ. Glucocorticoids regulate ovine hypophysial portal levels of corticotropin-releasing factor and arginine vasopressin in a stress-specific manner. Endocrinology. 125: 2532-9. PMID 2676486 DOI: 10.1210/ENDO-125-5-2532  0.298
2015 Clarke IJ. Hypothalamus as an endocrine organ. Comprehensive Physiology. 5: 217-53. PMID 25589270 DOI: 10.1002/cphy.c140019  0.298
1982 Clarke IJ, Funder JW, Findlay JK. Relationship between pituitary nuclear oestrogen receptors and the release of LH, FSH and prolactin in the ewe. Journal of Reproduction and Fertility. 64: 355-62. PMID 6802968 DOI: 10.1530/JRF.0.0640355  0.297
2003 Scott CJ, Mariani M, Clarke IJ, Tilbrook AJ. Effect of testosterone and season on proenkephalin messenger RNA expression in the preoptic area of the hypothalamus in the ram. Biology of Reproduction. 69: 2015-21. PMID 12930728 DOI: 10.1095/biolreprod.103.016956  0.295
1987 Gordon K, Renfree MB, Short RV, Clarke IJ. Hypothalamo-pituitary portal blood concentrations of beta-endorphin during suckling in the ewe. Journal of Reproduction and Fertility. 79: 397-408. PMID 2952792 DOI: 10.1530/Jrf.0.0790397  0.295
2008 Smith JT, Coolen LM, Kriegsfeld LJ, Sari IP, Jaafarzadehshirazi MR, Maltby M, Bateman K, Goodman RL, Tilbrook AJ, Ubuka T, Bentley GE, Clarke IJ, Lehman MN. Variation in kisspeptin and RFamide-related peptide (RFRP) expression and terminal connections to gonadotropin-releasing hormone neurons in the brain: a novel medium for seasonal breeding in the sheep. Endocrinology. 149: 5770-82. PMID 18617612 DOI: 10.1210/En.2008-0581  0.294
2011 Clarke IJ. Control of GnRH secretion: one step back. Frontiers in Neuroendocrinology. 32: 367-75. PMID 21216259 DOI: 10.1016/j.yfrne.2011.01.001  0.294
2013 Clarke IJ, Caraty A. Kisspeptin and seasonality of reproduction. Advances in Experimental Medicine and Biology. 784: 411-30. PMID 23550017 DOI: 10.1007/978-1-4614-6199-9_19  0.293
2001 Lincoln GA, Rhind SM, Pompolo S, Clarke IJ. Hypothalamic control of photoperiod-induced cycles in food intake, body weight, and metabolic hormones in rams. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 281: R76-90. PMID 11404281  0.293
1993 Klein R, Findlay JK, Clarke IJ, de Kretser DM, Robertson DM. Radioimmunoassay of FSH-suppressing protein in the ewe: concentrations during the oestrous cycle and following ovariectomy. The Journal of Endocrinology. 137: 433-43. PMID 8396621 DOI: 10.1677/JOE.0.1370433  0.293
1993 Clarke IJ, Scott CJ. Studies on the neuronal systems involved in the oestrogen-negative feedback effect on gonadotrophin releasing hormone neurons in the ewe Human Reproduction. 8: 2-6. PMID 8276961 DOI: 10.1093/humrep/8.suppl_2.2  0.292
1994 Smith AI, Tetaz T, Roberts JL, Glucksman M, Clarke IJ, Lew RA. The role of EC 3.4.24.15 in the post-secretory regulation of peptide signals. Biochimie. 76: 288-94. PMID 7819337 DOI: 10.1016/0300-9084(94)90160-0  0.292
1987 Fry RC, Cahill LP, Cummins JT, Bindon BM, Piper LR, Clarke IJ. The half-life of follicle-stimulating hormone in ovary-intact and ovariectomized booroola and control merino ewes. Journal of Reproduction and Fertility. 81: 611-5. PMID 3123660 DOI: 10.1530/JRF.0.0810611  0.29
2013 Fraley GS, Coombs E, Gerometta E, Colton S, Sharp PJ, Li Q, Clarke IJ. Distribution and sequence of gonadotropin-inhibitory hormone and its potential role as a molecular link between feeding and reproductive systems in the Pekin duck (Anas platyrhynchos domestica). General and Comparative Endocrinology. 184: 103-10. PMID 23354058 DOI: 10.1016/j.ygcen.2012.11.026  0.29
1983 Wright PJ, Clarke IJ, Findlay JK. The induction of fertile oestrus in seasonally anoestrous ewes using a continuous low dose administration of gonadotrophin releasing hormone. Australian Veterinary Journal. 60: 254-5. PMID 6357179 DOI: 10.1111/J.1751-0813.1983.TB05982.X  0.289
2010 Clarke IJ, Smith JT. The role of kisspeptin and gonadotropin inhibitory hormone (GnIH) in the seasonality of reproduction in sheep. Society of Reproduction and Fertility Supplement. 67: 159-69. PMID 21755670  0.289
1994 Wu D, Chen C, Katoh K, Zhang J, Clarke IJ. The effect of GH-releasing peptide-2 (GHRP-2 or KP 102) on GH secretion from primary cultured ovine pituitary cells can be abolished by a specific GH-releasing factor (GRF) receptor antagonist. The Journal of Endocrinology. 140: R9-13. PMID 8169551 DOI: 10.1677/JOE.0.140R009  0.289
1987 Clarke IJ, Cummins JT. The significance of small pulses of gonadotrophin-releasing hormone. The Journal of Endocrinology. 113: 413-8. PMID 3114406 DOI: 10.1677/JOE.0.1130413  0.288
2005 Iqbal J, Manley TR, Ciofi P, Clarke IJ. Reduction in adiposity affects the extent of afferent projections to growth hormone-releasing hormone and somatostatin neurons and the degree of colocalization of neuropeptides in growth hormone-releasing hormone and somatostatin cells of the ovine hypothalamus. Endocrinology. 146: 4776-85. PMID 16081637 DOI: 10.1210/en.2005-0622  0.288
1993 Tilbrook AJ, de Kretser DM, Clarke IJ. A role for inhibin in the regulation of the secretion of follicle stimulating hormone in male domestic animals. Domestic Animal Endocrinology. 9: 243-60. PMID 1473345 DOI: 10.1016/0739-7240(92)90013-N  0.287
2014 Lee TK, Lee C, Bischof R, Lambert GW, Clarke IJ, Henry BA. Stress-induced behavioral and metabolic adaptations lead to an obesity-prone phenotype in ewes with elevated cortisol responses. Psychoneuroendocrinology. 47: 166-77. PMID 25001966 DOI: 10.1016/j.psyneuen.2014.05.015  0.287
2015 Henry BA, Loughnan R, Hickford J, Young IR, St John JC, Clarke I. Differences in mitochondrial DNA inheritance and function align with body conformation in genetically lean and fat sheep. Journal of Animal Science. 93: 2083-93. PMID 26020304 DOI: 10.2527/jas.2014-8764  0.286
2006 Anukulkitch C, Rao A, Lincoln G, Clarke I. Influence of photoperiod and gonadal status on changes in gene expression for appetite regulating peptides and leptin receptor (Ob-Rb) in the hypothalamus of Soay rams Frontiers in Neuroendocrinology. 27: 9. DOI: 10.1016/J.Yfrne.2006.03.019  0.286
1989 Horton RJ, Francis H, Clarke IJ. Seasonal and steroid-dependent effects on the modulation of LH secretion in the ewe by intracerebroventricularly administered beta-endorphin or naloxone. The Journal of Endocrinology. 122: 509-17. PMID 2527942 DOI: 10.1677/JOE.0.1220509  0.285
2013 Lee K, Clarke I, Henry B. Innate differences in weight gain and associated behaviour can be marked by cortisol responsivity Obesity Research & Clinical Practice. 7. DOI: 10.1016/J.Orcp.2013.12.623  0.284
2009 Roseweir AK, Kauffman AS, Smith JT, Guerriero KA, Morgan K, Pielecka-Fortuna J, Pineda R, Gottsch ML, Tena-Sempere M, Moenter SM, Terasawa E, Clarke IJ, Steiner RA, Millar RP. Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 3920-9. PMID 19321788 DOI: 10.1523/Jneurosci.5740-08.2009  0.284
1990 Canny BJ, Clarke IJ, Funder JW. Adrenocorticotropin responses to endogenous and exogenous secretagogues in the sheep: specificity of glucocorticoid action. Neuroendocrinology. 51: 181-9. PMID 2154716 DOI: 10.1159/000125335  0.282
1998 Clarke IJ, Brown BW, Tran VV, Scott CJ, Fry R, Millar RP, Rao A. Neonatal immunization against gonadotropin-releasing hormone (GnRH) results in diminished GnRH secretion in adulthood. Endocrinology. 139: 2007-14. PMID 9528988 DOI: 10.1210/ENDO.139.4.5953  0.282
2002 Turner AI, Canny BJ, Hobbs RJ, Bond JD, Clarke IJ, Tilbrook AJ. Influence of sex and gonadal status of sheep on cortisol secretion in response to ACTH and on cortisol and LH secretion in response to stress: importance of different stressors. The Journal of Endocrinology. 173: 113-22. PMID 11927390 DOI: 10.1677/joe.0.1730113  0.281
1988 Thomas GB, Cummins JT, Clarke IJ. Secretion of prolactin in response to serotonin requires an intact hypothalamo-pituitary axis in the ewe. Neuroscience Letters. 85: 143-6. PMID 3362407 DOI: 10.1016/0304-3940(88)90444-2  0.281
2001 Clarke IJ, Henry B, Iqbal J, Goding JW. Leptin and the regulation of food intake and the neuroendocrine axis in sheep. Clinical and Experimental Pharmacology & Physiology. 28: 106-7. PMID 11153524  0.281
1988 Thomas GB, Cummins JT, Clarke IJ. Secretion of prolactin in response to serotonin requires an intact hypothalamo-pituitary axis in the ewe. Neuroscience Letters. 83: 323-6. PMID 3441315 DOI: 10.1016/0304-3940(87)90108-X  0.28
2016 Hewagalamulage SD, Clarke IJ, Rao A, Henry BA. Ewes with divergent Cortisol responses to Adrenocorticotropin (ACTH) exhibit functional differences in the Hypothalamo-Pituitary-Adrenal (HPA) axis. Endocrinology. en20161287. PMID 27414744 DOI: 10.1210/en.2016-1287  0.278
2001 Iqbal J, Pompolo S, Murakami T, Clarke IJ. Localization of long-form leptin receptor in the somatostatin-containing neurons in the sheep hypothalamus. Brain Research. 887: 1-6. PMID 11134583 DOI: 10.1016/S0006-8993(00)02912-7  0.278
1987 Clarke IJ, Cummins JT, Karsch FJ, Seeburg PH, Nikolics K. GnRH-associated peptide (GAP) is cosecreted with GnRH into the hypophyseal portal blood of ovariectomized sheep. Biochemical and Biophysical Research Communications. 143: 665-71. PMID 3551953 DOI: 10.1016/0006-291X(87)91405-7  0.277
2011 Keenan DM, Clarke IJ, Veldhuis JD. Noninvasive analytical estimation of endogenous GnRH drive: analysis using graded competitive GnRH-receptor antagonism and a calibrating pulse of exogenous GnRH. Endocrinology. 152: 4882-93. PMID 22028450 DOI: 10.1210/En.2011-1461  0.276
2015 Li Q, Millar RP, Clarke IJ, Smith JT. Evidence that Neurokinin B Controls Basal Gonadotropin-Releasing Hormone Secretion but Is Not Critical for Estrogen-Positive Feedback in Sheep. Neuroendocrinology. 101: 161-74. PMID 25677216 DOI: 10.1159/000377702  0.275
2006 Anukulkitch C, Rao A, McEwan J, Clarke I. Expression of NPY and POMC in the hypothalamic arcuate nucleus of genetically lean and fat sheep Frontiers in Neuroendocrinology. 27: 8-9. DOI: 10.1016/J.Yfrne.2006.03.018  0.275
2007 Smith JT, Clarke IJ. Kisspeptin expression in the brain: catalyst for the initiation of puberty. Reviews in Endocrine & Metabolic Disorders. 8: 1-9. PMID 17334929 DOI: 10.1007/S11154-007-9026-4  0.272
2010 Backholer K, Bowden M, Gamber K, Bjørbaek C, Iqbal J, Clarke IJ. Melanocortins mimic the effects of leptin to restore reproductive function in lean hypogonadotropic ewes. Neuroendocrinology. 91: 27-40. PMID 19923792 DOI: 10.1159/000260060  0.272
2008 Clarke IJ, Sari IP, Qi Y, Smith JT, Parkington HC, Ubuka T, Iqbal J, Li Q, Tilbrook A, Morgan K, Pawson AJ, Tsutsui K, Millar RP, Bentley GE. Potent action of RFamide-related peptide-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion. Endocrinology. 149: 5811-21. PMID 18617613 DOI: 10.1210/En.2008-0575  0.271
1992 Findlay J, Robertson D, Clarke I, Klein R, Doughton B, Xiao S, Russell D, Shukovski L. Hormonal regulation of reproduction — general concepts Animal Reproduction Science. 28: 319-328. DOI: 10.1016/0378-4320(92)90118-W  0.271
2009 Backholer K, Smith J, Clarke IJ. Melanocortins may stimulate reproduction by activating orexin neurons in the dorsomedial hypothalamus and kisspeptin neurons in the preoptic area of the ewe. Endocrinology. 150: 5488-97. PMID 19819961 DOI: 10.1210/En.2009-0604  0.27
1980 Clarke IJ, Findlay JK. Catechol oestrogens and gonadotrophin secretion in the ewe: affinity for pituitary oestrogen receptors invitro and action on gonadotrophin secretion in vivo. The Journal of Endocrinology. 85: 503-9. PMID 6774040 DOI: 10.1677/JOE.0.0850503  0.27
2009 Iqbal J, Latchoumanin O, Sari IP, Lang RJ, Coleman HA, Parkington HC, Clarke IJ. Estradiol-17beta inhibits gonadotropin-releasing hormone-induced Ca2+ in gonadotropes to regulate negative feedback on luteinizing hormone release. Endocrinology. 150: 4213-20. PMID 19477939 DOI: 10.1210/en.2009-0092  0.27
2007 Smith JT, Clay CM, Caraty A, Clarke IJ. KiSS-1 messenger ribonucleic acid expression in the hypothalamus of the ewe is regulated by sex steroids and season. Endocrinology. 148: 1150-7. PMID 17185374 DOI: 10.1210/En.2006-1435  0.269
2005 Broadbear JH, Pierce BN, Clarke IJ, Canny BJ. Role of sex and sex steroids in mediating pituitary-adrenal responses to acute buspirone treatment in sheep. Journal of Neuroendocrinology. 17: 804-10. PMID 16280027 DOI: 10.1111/j.1365-2826.2005.01368.x  0.268
2010 Smith JT, Clarke IJ. Seasonal breeding as a neuroendocrine model for puberty in sheep. Molecular and Cellular Endocrinology. 324: 102-9. PMID 20298744 DOI: 10.1016/J.Mce.2010.03.007  0.268
2010 Tschöp J, Nogueiras R, Haas-Lockie S, Kasten KR, Castañeda TR, Huber N, Guanciale K, Perez-Tilve D, Habegger K, Ottaway N, Woods SC, Oldfield B, Clarke I, Chua S, Farooqi IS, et al. CNS leptin action modulates immune response and survival in sepsis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 6036-47. PMID 20427662 DOI: 10.1523/Jneurosci.4875-09.2010  0.266
2014 Clarke IJ. Interface between metabolic balance and reproduction in ruminants: focus on the hypothalamus and pituitary. Hormones and Behavior. 66: 15-40. PMID 24568750 DOI: 10.1016/j.yhbeh.2014.02.005  0.266
2002 Turner AI, Rivalland ET, Clarke IJ, Lambert GW, Morris MJ, Tilbrook AJ. Noradrenaline, but not neuropeptide Y, is elevated in cerebrospinal fluid from the third cerebral ventricle following audiovisual stress in gonadectomised rams and ewes. Neuroendocrinology. 76: 373-80. PMID 12566945  0.265
1996 Heyward PM, Clarke IJ. A transient effect of estrogen on calcium currents and electrophysiological responses to gonadotropin-releasing hormone in ovine gonadotropes. Neuroendocrinology. 62: 543-52. PMID 8751279 DOI: 10.1159/000127050  0.265
2005 Iqbal J, Manley TR, Yue Q, Namavar MR, Clarke IJ. Noradrenergic regulation of hypothalamic cells that produce growth hormone-releasing hormone and somatostatin and the effect of altered adiposity in sheep. Journal of Neuroendocrinology. 17: 341-52. PMID 15929740 DOI: 10.1111/j.1365-2826.2005.01319.x  0.264
1978 Clarke IJ, Scaramuzzi RJ. Sexual behaviour and LH secretion in spayed androgenized ewes after a s?ngle injection of testosterone or oestradiol-17beta. Journal of Reproduction and Fertility. 52: 313-20. PMID 564961 DOI: 10.1530/JRF.0.0520313  0.264
2017 Simon MJK, Beil FT, Pogoda P, Vettorazzi E, Clarke I, Amling M, Oheim R. Is centrally induced alveolar bone loss in a large animal model preventable by peripheral hormone substitution? Clinical Oral Investigations. PMID 28573521 DOI: 10.1007/S00784-017-2138-7  0.263
1998 Thomas SG, Takahashi M, Neill JD, Clarke IJ. Components of the neuronal exocytotic machinery in the anterior pituitary of the ovariectamised ewe and the effects of oestrogen in gonadotropes as studied with confocal microscopy Neuroendocrinology. 67: 244-259. PMID 9588694 DOI: 10.1159/000054320  0.263
1998 Komesaroff PA, Esler M, Clarke IJ, Fullerton MJ, Funder JW. Effects of estrogen and estrous cycle on glucocorticoid and catecholamine responses to stress in sheep. American Journal of Physiology. Endocrinology and Metabolism. 275: E671-E678. PMID 29590954 DOI: 10.1152/ajpendo.1998.275.4.E671  0.263
2003 Lincoln GA, Andersson H, Clarke IJ. Prolactin cycles in sheep under constant photoperiod: evidence that photorefractoriness develops within the pituitary gland independently of the prolactin output signal. Biology of Reproduction. 69: 1416-23. PMID 12826582 DOI: 10.1095/biolreprod.103.017673  0.261
2014 Otto JR, Malau-Aduli BS, Rao A, Clarke IJ, Malau-Aduli AEO. Effect of incremental levels of crude degummed canola oil on milk progesterone, plasma luteinizing and follicle stimulating hormones of primiparous Holstein–Friesian cows in a pasture-based system International Journal of Veterinary Science and Medicine. 2: 122-129. DOI: 10.1016/j.ijvsm.2014.10.001  0.261
1991 McNatty KP, Heath DA, Hudson N, Clarke IJ. Effect of long-term hypophysectomy on ovarian follicle populations and gonadotrophin-induced adenosine cyclic 3',5'-monophosphate output by follicles from Booroola ewes with or without the F gene. Journal of Reproduction and Fertility. 90: 515-22. PMID 2174458 DOI: 10.1530/JRF.0.0900515  0.261
2009 Smith JT, Li Q, Pereira A, Clarke IJ. Kisspeptin neurons in the ovine arcuate nucleus and preoptic area are involved in the preovulatory luteinizing hormone surge. Endocrinology. 150: 5530-8. PMID 19819940 DOI: 10.1210/En.2009-0712  0.26
2006 Pompolo S, Pereira A, Estrada KM, Clarke IJ. Colocalization of kisspeptin and gonadotropin-releasing hormone in the ovine brain. Endocrinology. 147: 804-10. PMID 16293663 DOI: 10.1210/en.2005-1123  0.259
1996 Walsh JP, Clarke IJ. Effects of central administration of highly selective opioid mu-, delta- and kappa-receptor agonists on plasma luteinizing hormone (LH), prolactin, and the estrogen-induced LH surge in ovariectomized ewes. Endocrinology. 137: 3640-8. PMID 8756528 DOI: 10.1210/endo.137.9.8756528  0.259
2013 De Bond JA, Li Q, Millar RP, Clarke IJ, Smith JT. Kisspeptin signaling is required for the luteinizing hormone response in anestrous ewes following the introduction of males. Plos One. 8: e57972. PMID 23469121 DOI: 10.1371/Journal.Pone.0057972  0.258
1993 Shen PJ, Clarke IJ, Funder JW, Smith AI. Characterization of immunoreactive AVP in the ovine hypothalamo-pituitary axis. Peptides. 14: 815-20. PMID 8234030 DOI: 10.1016/0196-9781(93)90119-2  0.257
1989 Wright P, Geytenbeek P, Clarke I, Hoskinson R. The efficacy of ram introduction, GnRH administration, and immunisation against androstenedione and oestrone for the induction of oestrus and ovulation in anoestrous post-partum ewes Animal Reproduction Science. 21: 237-247. DOI: 10.1016/0378-4320(89)90031-6  0.257
2017 Weems P, Smith J, Clarke IJ, Coolen LM, Goodman RL, Lehman MN. Effects of season and estradiol on KNDy neuron peptides, colocalization with D2 dopamine receptors, and dopaminergic inputs, in the ewe. Endocrinology. PMID 28324006 DOI: 10.1210/En.2016-1830  0.257
2019 Lee CY, Li S, Li XF, Stalker DAE, Cooke C, Shao B, Kelestimur H, Henry BA, Conductier G, O'Byrne KT, Clarke IJ. Lipopolysaccharide reduces gonadotrophin-releasing hormone (GnRH) gene expression: role of RFamide-related peptide-3 and kisspeptin. Reproduction, Fertility, and Development. PMID 30922440 DOI: 10.1071/RD18277  0.256
2019 Fuller-Jackson J, Dordevic A, Truby H, Clarke I, Henry B. MON-LB016 Sex and Sex Steroid Effects on Brown Adipose Tissue Temperature in Healthy Humans Journal of the Endocrine Society. 3. DOI: 10.1210/Js.2019-Mon-Lb016  0.254
1997 Wu D, Clarke IJ, Chen C. The role of protein kinase C in GH secretion induced by GH-releasing factor and GH-releasing peptides in cultured ovine somatotrophs. The Journal of Endocrinology. 154: 219-30. PMID 9291832 DOI: 10.1677/JOE.0.1540219  0.254
2001 Scott CJ, Pereira AM, Tilbrook AJ, Rawson JA, Clarke IJ. Changes in preoptic and hypothalamic levels of progesterone receptor mRNA across the oestrous cycle of the ewe. Journal of Neuroendocrinology. 13: 401-6. PMID 11328448 DOI: 10.1046/j.1365-2826.2001.00641.x  0.254
1994 Law FM, Leaver DD, Martin TJ, Selleck K, Clarke IJ, Moate PJ. Effect of treatment of dairy cows with slow-release bovine somatotropin during the periparturient period on minerals in plasma and milk and on parathyroid hormone-related protein in milk. Journal of Dairy Science. 77: 2242-8. PMID 7962846 DOI: 10.3168/JDS.S0022-0302(94)77167-8  0.251
1999 Canny BJ, O'Farrell KA, Clarke IJ, Tilbrook AJ. The influence of sex and gonadectomy on the hypothalamo-pituitary-adrenal axis of the sheep. The Journal of Endocrinology. 162: 215-25. PMID 10425459 DOI: 10.1677/joe.0.1620215  0.249
2002 Clarke IJ. Two decades of measuring GnRH secretion. Reproduction (Cambridge, England) Supplement. 59: 1-13. PMID 12698969  0.249
2002 Lincoln GA, Clarke IJ. Noradrenaline and dopamine regulation of prolactin secretion in sheep: role in prolactin homeostasis but not photoperiodism. Journal of Neuroendocrinology. 14: 36-44. PMID 11903811 DOI: 10.1046/j.0007-1331.2001.00734.x  0.249
1994 Heyward PM, Chen C, Clarke IJ. Gonadotropin-releasing hormone modifies action potential generation in sheep pars distalis gonadotropes. Neuroendocrinology. 58: 646-54. PMID 7510370 DOI: 10.1159/000126605  0.248
2021 Burke CR, Roche JR, Millar RP, Clarke IJ. Onset of normal cycles in postpartum anovulatory dairy cattle treated with kisspeptin. Reproduction & Fertility. 3: 1-8. PMID 35118417 DOI: 10.1530/RAF-21-0046  0.247
1992 Lew RA, Clarke IJ, Smith AI. Distribution and characterization of peptidylglycine alpha-amidating monooxygenase activity in the ovine brain and hypothalamo-pituitary axis. Endocrinology. 130: 994-1000. PMID 1733739 DOI: 10.1210/ENDO.130.2.1733739  0.246
2015 Hewagalamulage SD, Clarke IJ, Young IR, Rao A, Henry BA. High cortisol response to adrenocorticotrophic hormone identifies ewes with reduced melanocortin signalling and increased propensity to obesity. Journal of Neuroendocrinology. 27: 44-56. PMID 25315658 DOI: 10.1111/jne.12233  0.246
1990 Shen PJ, Clarke IJ, Canny BJ, Funder JW, Smith AI. Arginine vasopressin and corticotropin releasing factor: binding to ovine anterior pituitary membranes. Endocrinology. 127: 2085-9. PMID 2226302 DOI: 10.1210/ENDO-127-5-2085  0.246
2008 Pierce BN, Hemsworth PH, Rivalland ET, Wagenmaker ER, Morrissey AD, Papargiris MM, Clarke IJ, Karsch FJ, Turner AI, Tilbrook AJ. Psychosocial stress suppresses attractivity, proceptivity and pulsatile LH secretion in the ewe. Hormones and Behavior. 54: 424-34. PMID 18519136 DOI: 10.1016/j.yhbeh.2008.04.005  0.243
2013 Jacobi JS, Coleman HA, Enriori PJ, Parkington HC, Li Q, Pereira A, Cowley MA, Clarke IJ. Paradoxical effect of gonadotrophin-inhibiting hormone to negatively regulate neuropeptide Y neurones in mouse arcuate nucleus. Journal of Neuroendocrinology. 25: 1308-17. PMID 24118324 DOI: 10.1111/jne.12114  0.243
1995 Pomares C, Galloway D, Holmes J, Clarke I, Tilbrook A. Lupin and cowpea supplements for growth, wool production, and reproduction in rams Australian Journal of Experimental Agriculture. 35: 447. DOI: 10.1071/EA9950447  0.243
2012 Tilbrook AJ, Clarke IJ. Evidence that Dopaminergic Neurons are not Involved in the Negative Feedback Effect of Testosterone on Luteinizing Hormone in Rams in the Non-Breeding Season. Journal of Neuroendocrinology. 4: 365-74. PMID 21554619 DOI: 10.1111/j.1365-2826.1992.tb00181.x  0.242
1989 Mercer JE, Clements JA, Clarke IJ, Funder JW. Glucocorticoid regulation of proopiomelanocortin gene expression in the pituitary gland of hypothalamopituitary intact and hypothalamopituitary disconnected sheep Neuroendocrinology. 50: 280-285. PMID 2797383 DOI: 10.1159/000125234  0.241
1996 Phillips DJ, Hedger MP, McFarlane JR, Klein R, Clarke IJ, Tilbrook AJ, Nash AD, de Kretser DM. Follistatin concentrations in male sheep increase following sham castration/castration or injection of interleukin-1 beta. The Journal of Endocrinology. 151: 119-24. PMID 8943776 DOI: 10.1677/JOE.0.1510119  0.24
2000 Iqbal J, Pompolo S, Considine RV, Clarke IJ. Localization of leptin receptor-like immunoreactivity in the corticotropes, somatotropes, and gonadotropes in the ovine anterior pituitary. Endocrinology. 141: 1515-20. PMID 10746658 DOI: 10.1210/ENDO.141.4.7433  0.237
2010 Qi Y, Henry BA, Oldfield BJ, Clarke IJ. The action of leptin on appetite-regulating cells in the ovine hypothalamus: demonstration of direct action in the absence of the arcuate nucleus. Endocrinology. 151: 2106-16. PMID 20308532 DOI: 10.1210/en.2009-1283  0.237
2007 Anukulkitch C, Rao A, Dunshea FR, Blache D, Lincoln GA, Clarke IJ. Influence of photoperiod and gonadal status on food intake, adiposity, and gene expression of hypothalamic appetite regulators in a seasonal mammal. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 292: R242-52. PMID 16917018 DOI: 10.1152/ajpregu.00417.2006  0.237
2002 Tilbrook AJ, Turner AI, Clarke IJ. Stress and reproduction: central mechanisms and sex differences in non-rodent species. Stress (Amsterdam, Netherlands). 5: 83-100. PMID 12186687 DOI: 10.1080/10253890290027912  0.237
2001 Clarke IJ, Pompolo S, Scott CJ, Rawson JA, Caddy D, Jakubowska AE, Pereira AM. Cells of the arcuate nucleus and ventromedial nucleus of the ovariectomized ewe that respond to oestrogen: a study using Fos immunohistochemistry. Journal of Neuroendocrinology. 13: 934-41. PMID 11737551 DOI: 10.1046/j.1365-2826.2001.00694.x  0.237
2008 Tilbrook AJ, Rivalland EA, Turner AI, Lambert GW, Clarke IJ. Responses of the hypothalamopituitary adrenal axis and the sympathoadrenal system to isolation/restraint stress in sheep of different adiposity. Neuroendocrinology. 87: 193-205. PMID 18285679 DOI: 10.1159/000117576  0.237
1980 Scaramuzzi RJ, Baird DT, Clarke IJ, Martensz ND, Van Look PF. Ovarian morphology and the concentration of steroids during the oestrus cycle of sheep actively immunized against androstenedione. Journal of Reproduction and Fertility. 58: 27-35. PMID 7188971 DOI: 10.1530/JRF.0.0580027  0.236
1987 Findlay JK, Robertson DM, Clarke IJ. Influence of dose and route of administration of bovine follicular fluid and the suppressive effect of purified bovine inhibin (Mr 31,000) on plasma FSH concentrations in ovariectomized ewes. Journal of Reproduction and Fertility. 80: 455-61. PMID 3116231 DOI: 10.1530/JRF.0.0800455  0.235
1989 Engler D, Pham T, Fullerton MJ, Clarke IJ, Funder JW. Evidence for an ultradian secretion of adrenocorticotropin, beta-endorphin and alpha-melanocyte-stimulating hormone by the ovine anterior and intermediate pituitary. Neuroendocrinology. 49: 349-60. PMID 2541359 DOI: 10.1159/000125139  0.234
2001 Walsh JP, Rao A, Thompson RC, Clarke IJ. Proenkephalin and opioid mu-receptor mRNA expression in ovine hypothalamus across the estrous cycle. Neuroendocrinology. 73: 26-36. PMID 11174014  0.233
1996 Tilbrook AJ, de Kretser DM, Dunshea FR, Klein R, Robertson DM, Clarke IJ, Maddocks S. The testis is not the major source of circulating follistatin in the ram. The Journal of Endocrinology. 149: 55-63. PMID 8676054 DOI: 10.1677/JOE.0.1490055  0.233
1989 Mercer JE, Clements JA, Funder JW, Clarke IJ. Regulation of follicle-stimulating hormone β and common α-subunit messenger ribonucleic acid by gonadotropin-releasing hormone and estrogen in the sheep pituitary Neuroendocrinology. 50: 321-326. PMID 2477765 DOI: 10.1159/000125240  0.232
2010 Anukulkitch C, Rao A, Pereira A, McEwan J, Clarke IJ. Expression of genes for appetite-regulating peptides in the hypothalamus of genetically selected lean and fat sheep. Neuroendocrinology. 91: 223-38. PMID 19940452 DOI: 10.1159/000262283  0.231
2000 Opeskin K, Clarke I, Berkovic SF. Prolactin levels in sudden unexpected death in epilepsy. Epilepsia. 41: 48-51. PMID 10643923 DOI: 10.1111/J.1528-1157.2000.Tb01504.X  0.23
2006 Rivalland ET, Tilbrook AJ, Turner AI, Iqbal J, Pompolo S, Clarke IJ. Projections to the preoptic area from the paraventricular nucleus, arcuate nucleus and the bed nucleus of the stria terminalis are unlikely to be involved in stress-induced suppression of GnRH secretion in sheep. Neuroendocrinology. 84: 1-13. PMID 17047317 DOI: 10.1159/000096372  0.23
2010 Clarke IJ, Tilbrook AJ. Gonadotropin, Neural and Hormonal Control Encyclopedia of Neuroscience. 959-965. DOI: 10.1016/B978-008045046-9.01165-7  0.23
2001 Iqbal J, Pompolo S, Sakurai T, Clarke IJ. Evidence that orexin-containing neurones provide direct input to gonadotropin-releasing hormone neurones in the ovine hypothalamus. Journal of Neuroendocrinology. 13: 1033-41. PMID 11722699 DOI: 10.1046/J.1365-2826.2001.00719.X  0.228
2004 Jones KL, de Kretser DM, Clarke IJ, Scheerlinck JP, Phillips DJ. Characterisation of the rapid release of activin A following acute lipopolysaccharide challenge in the ewe. The Journal of Endocrinology. 182: 69-80. PMID 15225132  0.227
2001 Pompolo S, Rawson JA, Clarke IJ. Projections from the arcuate/ventromedial region of the hypothalamus to the preoptic area and bed nucleus of stria terminalis in the brain of the ewe; lack of direct input to gonadotropin-releasing hormone neurons. Brain Research. 904: 1-12. PMID 11516406 DOI: 10.1016/S0006-8993(01)02372-1  0.222
2008 Wagner GC, Johnston JD, Clarke IJ, Lincoln GA, Hazlerigg DG. Redefining the limits of day length responsiveness in a seasonal mammal. Endocrinology. 149: 32-9. PMID 17901234 DOI: 10.1210/en.2007-0658  0.221
1987 Clarke IJ, Clements JA, Cummins JT, Dench F, Smith AI, Robinson PM, Funder JW. Elevated plasma levels of pro-opiomelanocortin-derived peptides in sheep following hypothalamo-pituitary disconnection. Neuroendocrinology. 44: 508-14. PMID 3029616 DOI: 10.1159/000124693  0.22
2006 Tilbrook AJ, Clarke IJ. Neuroendocrine mechanisms of innate states of attenuated responsiveness of the hypothalamo-pituitary adrenal axis to stress. Frontiers in Neuroendocrinology. 27: 285-307. PMID 16930683 DOI: 10.1016/j.yfrne.2006.06.002  0.217
2000 Scott CJ, Tilbrook AJ, Rawson JA, Clarke IJ. Gonadal steroid receptors in the regulation of GnRH secretion in farm animals. Animal Reproduction Science. 60: 313-26. PMID 10844203 DOI: 10.1016/S0378-4320(00)00103-2  0.217
2020 Li Q, Smith JT, Henry B, Rao A, Pereira A, Clarke IJ. Expression of genes for Kisspeptin (KISS1), Neurokinin B (TAC3), Prodynorphin (PDYN), and gonadotropin inhibitory hormone (RFRP) across natural puberty in ewes. Physiological Reports. 8: e14399. PMID 32170819 DOI: 10.14814/Phy2.14399  0.216
2001 Iqbal J, Pompolo S, Murakami T, Grouzmann E, Sakurai T, Meister B, Clarke IJ. Immunohistochemical characterization of localization of long-form leptin receptor (OB-Rb) in neurochemically defined cells in the ovine hypothalamus. Brain Research. 920: 55-64. PMID 11716811 DOI: 10.1016/S0006-8993(01)02932-8  0.216
2005 Clarke IJ, Backholer K, Tilbrook AJ. Y2 receptor-selective agonist delays the estrogen-induced luteinizing hormone surge in ovariectomized ewes, but y1-receptor-selective agonist stimulates voluntary food intake. Endocrinology. 146: 769-75. PMID 15528305 DOI: 10.1210/en.2004-1085  0.216
2008 Henry BA, Clarke IJ. Adipose tissue hormones and the regulation of food intake. Journal of Neuroendocrinology. 20: 842-9. PMID 18601708 DOI: 10.1111/j.1365-2826.2008.1730.x  0.215
2016 Barrell GK, Ridgway MJ, Wellby M, Pereira A, Henry BA, Clarke IJ. Expression of regulatory neuropeptides in the hypothalamus of red deer (Cervus elaphus) reveals anomalous relationships in the seasonal control of appetite and reproduction. General and Comparative Endocrinology. 229: 1-7. PMID 26899722 DOI: 10.1016/j.ygcen.2016.02.020  0.214
1987 Mercer JE, Clements JA, Funder JW, Clarke IJ. Rapid and specific lowering of pituitary FSH beta mRNA levels by inhibin. Molecular and Cellular Endocrinology. 53: 251-4. PMID 3117603 DOI: 10.1016/0303-7207(87)90181-X  0.214
2005 Dufourny L, Caraty A, Clarke IJ, Robinson JE, Skinner DC. Progesterone-receptive dopaminergic and neuropeptide Y neurons project from the arcuate nucleus to gonadotropin-releasing hormone-rich regions of the ovine preoptic area. Neuroendocrinology. 82: 21-31. PMID 16330883 DOI: 10.1159/000090122  0.214
2007 Iqbal J, Latchoumanin O, Clarke IJ. Rapid in vivo effects of estradiol-17beta in ovine pituitary gonadotropes are displayed by phosphorylation of extracellularly regulated kinase, serine/threonine kinase, and 3',5'-cyclic adenosine 5'-monophosphate-responsive element-binding protein. Endocrinology. 148: 5794-802. PMID 17823264 DOI: 10.1210/en.2007-0986  0.214
2000 Clarke IJ, Scott CJ, Rao A, Pompolo S, Barker-Gibb ML. Seasonal changes in the expression of neuropeptide Y and pro-opiomelanocortin mRNA in the arcuate nucleus of the ovariectomized ewe: Relationship to the seasonal appetite and breeding cycles Journal of Neuroendocrinology. 12: 1105-1111. PMID 11069126 DOI: 10.1046/j.1365-2826.2000.00570.x  0.213
1985 Cargill C, Lee K, Clarke I. Use of an enzyme‐linked immunosorbent assay in a bovine brucellosis eradication program Australian Veterinary Journal. 62: 49-52. PMID 3922342 DOI: 10.1111/J.1751-0813.1985.Tb14233.X  0.213
2012 Clarke IJ. The preovulatory LH surge A case of a neuroendocrine switch. Trends in Endocrinology and Metabolism: Tem. 6: 241-7. PMID 18406707 DOI: 10.1016/1043-2760(95)95218-T  0.213
2009 Clarke IJ, Smith JT, Caraty A, Goodman RL, Lehman MN. Kisspeptin and seasonality in sheep. Peptides. 30: 154-63. PMID 18838092 DOI: 10.1016/J.Peptides.2008.08.022  0.213
2008 Scott CJ, Clarke IJ, Wilkins J, Flatscher-Bader T, Martin GB, Tilbrook AJ. 275. The endocrine disruptor, bisphenol A, alters gene expression in the hypothalamus of the ram lamb but does not alter LH secretion Reproduction, Fertility and Development. 20: 75. DOI: 10.1071/SRB08ABS275  0.212
2004 Broadbear JH, Nguyen T, Clarke IJ, Canny BJ. Antidepressants, sex steroids and pituitary-adrenal response in sheep. Psychopharmacology. 175: 247-55. PMID 14997276 DOI: 10.1007/s00213-004-1811-0  0.212
2005 Rivalland ET, Iqbal J, Clarke IJ, Turner AI, Tilbrook AJ. Co-localization and distribution of corticotrophin-releasing hormone, arginine vasopressin and enkephalin in the paraventricular nucleus of sheep: a sex comparison. Neuroscience. 132: 755-66. PMID 15837136 DOI: 10.1016/j.neuroscience.2005.01.045  0.211
1989 Thomas GB, Cummins JT, Doughton BW, Griffin N, Smythe GA, Gleeson RM, Clarke IJ. Direct pituitary inhibition of prolactin secretion by dopamine and noradrenaline in sheep Journal of Endocrinology. 123: 393-402. PMID 2607250 DOI: 10.1677/JOE.0.1230393  0.211
1993 Clarke IJ, Rao A, Fallest PC, Shupnik MA. Transcription rate of the follicle stimulating hormone (FSH) beta subunit gene is reduced by inhibin in sheep but this does not fully explain the decrease in mRNA. Molecular and Cellular Endocrinology. 91: 211-6. PMID 8472850 DOI: 10.1016/0303-7207(93)90274-N  0.211
1988 Smith AI, Engler D, Fullerton MJ, Pham T, Wallace C, Morgan FJ, Clarke IJ, Funder JW. Posttranslational processing of corticotropin-releasing factor in the ovine tuberoinfundibular system and pituitary. Annals of the New York Academy of Sciences. 512: 24-47. PMID 3502065 DOI: 10.1111/j.1749-6632.1987.tb24949.x  0.21
2003 Clarke IJ, Rao A, Chilliard Y, Delavaud C, Lincoln GA. Photoperiod effects on gene expression for hypothalamic appetite-regulating peptides and food intake in the ram. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 284: R101-15. PMID 12388437 DOI: 10.1152/ajpregu.00424.2002  0.21
2011 Papargiris MM, Rivalland ET, Clarke IJ, Smith JT, Pereira A, Tilbrook AJ. Evidence that RF-amide related peptide-3 is not a mediator of the inhibitory effects of psychosocial stress on gonadotrophin secretion in ovariectomised ewes. Journal of Neuroendocrinology. 23: 208-15. PMID 21073555 DOI: 10.1111/J.1365-2826.2010.02094.X  0.209
2003 Pompolo S, Pereira A, Scott CJ, Fujiyma F, Clarke IJ. Evidence for estrogenic regulation of gonadotropin-releasing hormone neurons by glutamatergic neurons in the ewe brain: An immunohistochemical study using an antibody against vesicular glutamate transporter-2. The Journal of Comparative Neurology. 465: 136-44. PMID 12926021 DOI: 10.1002/cne.10805  0.208
1977 Clarke IJ, Scaramuzzi RJ, Short RV. Ovulation in prenatally androgenized ewes. The Journal of Endocrinology. 73: 385-9. PMID 864374 DOI: 10.1677/JOE.0.0730385  0.207
2000 Tilbrook AJ, Turner AI, Clarke IJ. Effects of stress on reproduction in non-rodent mammals: the role of glucocorticoids and sex differences. Reviews of Reproduction. 5: 105-13. PMID 10864855 DOI: 10.1530/ROR.0.0050105  0.206
2011 Pedersen JS, Clarke I, Mills J. Improved detection of mycobacteria species in formalin-fixed tissue sections. Histopathology. 59: 993-1005. PMID 22092411 DOI: 10.1111/j.1365-2559.2011.04015.x  0.205
2001 Clarke IJ, Tilbrook AJ, Turner AI, Doughton BW, Goding JW. Sex, fat and the tilt of the earth: effects of sex and season on the feeding response to centrally administered leptin in sheep. Endocrinology. 142: 2725-8. PMID 11356725 DOI: 10.1210/endo.142.6.8318  0.205
2002 Clarke IJ. Multifarious effects of estrogen on the pituitary gonadotrope with special emphasis on studies in the ovine species. Archives of Physiology and Biochemistry. 110: 62-73. PMID 11935402 DOI: 10.1076/apab.110.1.62.898  0.204
2018 Aldaoud A, Soto-Breceda A, Tong W, Conductier G, Tonta MA, Coleman HA, Parkington HC, Clarke I, Redoute J, Garrett DJ, Prawer S. Wireless multichannel optogenetic stimulators enabled by narrow bandwidth resonant tank circuits Sensors and Actuators a: Physical. 271: 201-211. DOI: 10.1016/J.Sna.2017.12.051  0.201
2000 Smith AI, Shrimpton CN, Norman UM, Clarke IJ, Wolfson AJ, Lew RA. Neuropeptidases regulating gonadal function Biochemical Society Transactions. 28: 430-434. PMID 10961934  0.201
2007 Rivalland ET, Clarke IJ, Turner AI, Pompolo S, Tilbrook AJ. Isolation and restraint stress results in differential activation of corticotrophin-releasing hormone and arginine vasopressin neurons in sheep. Neuroscience. 145: 1048-58. PMID 17289277 DOI: 10.1016/j.neuroscience.2006.12.045  0.201
1990 Wright P, Geytenbeek P, Clarke I. The influence of nutrient status of post-partum ewes on ovarian cyclicity and on the oestrous and ovulatory responses to ram introduction Animal Reproduction Science. 23: 293-303. DOI: 10.1016/0378-4320(90)90043-F  0.201
1993 Chen C, Zhang J, McNeill P, Pullar M, Cummins JT, Clarke IJ. Human growth hormone releasing factor (hGRF) modulates calcium currents in human growth hormone secreting adenoma cells. Brain Research. 604: 345-8. PMID 8384513 DOI: 10.1016/0006-8993(93)90389-5  0.199
1996 Gatford KL, Fletcher TP, Clarke IJ, Owens PC, Quinn KJ, Walton PE, Grant PA, Hosking BJ, Egan AR, Ponnampalam EN. Sexual dimorphism of circulating somatotropin, insulin-like growth factor I and II, insulin-like growth factor binding proteins, and insulin: relationships to growth rate and carcass characteristics in growing lambs. Journal of Animal Science. 74: 1314-25. PMID 8791204 DOI: 10.2527/1996.7461314X  0.198
1996 Klein R, Clarke IJ, Hedger MP, Robertson DM. Plasma follistatin concentrations increase following lipopolysaccharide administration in sheep. Clinical and Experimental Pharmacology & Physiology. 23: 754-5. PMID 8886504 DOI: 10.1111/j.1440-1681.1996.tb01773.x  0.197
2005 Pompolo S, Ischenko O, Pereira A, Iqbal J, Clarke IJ. Evidence that projections from the bed nucleus of the stria terminalis and from the lateral and medial regions of the preoptic area provide input to gonadotropin releasing hormone (GNRH) neurons in the female sheep brain. Neuroscience. 132: 421-36. PMID 15802194 DOI: 10.1016/j.neuroscience.2004.12.042  0.197
2010 Backholer K, Smith JT, Rao A, Pereira A, Iqbal J, Ogawa S, Li Q, Clarke IJ. Kisspeptin cells in the ewe brain respond to leptin and communicate with neuropeptide Y and proopiomelanocortin cells. Endocrinology. 151: 2233-43. PMID 20207832 DOI: 10.1210/En.2009-1190  0.197
2006 Lincoln GA, Clarke IJ, Hut RA, Hazlerigg DG. Characterizing a mammalian circannual pacemaker. Science (New York, N.Y.). 314: 1941-4. PMID 17185605 DOI: 10.1126/science.1132009  0.196
2001 Henry BA, Rao A, Ikenasio BA, Mountjoy KG, Tilbrook AJ, Clarke IJ. Differential expression of cocaine- and amphetamine-regulated transcript and agouti related-protein in chronically food-restricted sheep. Brain Research. 918: 40-50. PMID 11684040  0.194
2013 Tariq AR, Shahab M, Clarke IJ, Pereira A, Smith JT, Khan SuH, Sultan J, Javed S, Anwar T. Kiss1 and Kiss1 receptor expression in the rhesus monkey testis: A possible local regulator of testicular function Central European Journal of Biology. 8: 968-974. DOI: 10.2478/S11535-013-0219-4  0.191
1993 Curlewis JD, Clarke IJ, McNeilly AS. Dopamine D1 receptor analogues act centrally to stimulate prolactin secretion in ewes. The Journal of Endocrinology. 137: 457-64. PMID 8371076 DOI: 10.1677/JOE.0.1370457  0.19
1979 Hossain MI, Lee CS, Clarke IJ, O'Shea JD. Ovarian and luteal blood flow, and peripheral plasma progesterone levels, in cyclic guinea-pigs Journal of Reproduction and Fertility. 57: 167-174. PMID 574546 DOI: 10.1530/JRF.0.0570167  0.189
2006 Tilbrook AJ, Turner AI, Ibbott MD, Clarke IJ. Activation of the hypothalamo-pituitary-adrenal axis by isolation and restraint stress during lactation in ewes: effect of the presence of the lamb and suckling. Endocrinology. 147: 3501-9. PMID 16574791 DOI: 10.1210/en.2005-1632  0.189
2009 Anukulkitch C, Rao A, Dunshea FR, Clarke IJ. A test of the lipostat theory in a seasonal (ovine) model under natural conditions reveals a close relationship between adiposity and melanin concentrating hormone expression. Domestic Animal Endocrinology. 36: 138-51. PMID 19179037 DOI: 10.1016/j.domaniend.2008.12.002  0.188
1998 Canny BJ, O'Farrell KA, Clarke IJ, Tilbrook AJ. Angiotensin II- and phorbol ester-induced steroidogenesis by ovine adrenocortical cells: effect of sex and the gonadal status of the donor animal. Clinical and Experimental Pharmacology & Physiology. 25: 401-4. PMID 9673813 DOI: 10.1111/j.1440-1681.1998.tb02222.x  0.188
1996 Thom B, Canny BJ, Cowley M, Wright PJ, Clarke IJ. Changes in the binding characteristics of the mu, delta and kappa subtypes of the opioid receptor in the hypothalamus of the normal cyclic ewe and in the ovariectomised ewe following treatment with ovarian steroids. The Journal of Endocrinology. 149: 509-18. PMID 8691110 DOI: 10.1677/JOE.0.1490509  0.188
2016 Fahri FT, Clarke IJ, Pethick DW, Warner RD, Dunshea FR. Rosiglitazone maleate increases weight gain and body fat content in growing lambs Animal Production Science. 56: 1185-1193. DOI: 10.1071/AN14885  0.187
2000 Scott CJ, Pereira AM, Rawson JA, Simmons DM, Rossmanith WG, Ing NH, Clarke IJ. The distribution of progesterone receptor immunoreactivity and mRNA in the preoptic area and hypothalamus of the ewe: upregulation of progesterone receptor mRNA in the mediobasal hypothalamus by oestrogen. Journal of Neuroendocrinology. 12: 565-75. PMID 10844586 DOI: 10.1046/J.1365-2826.2000.00490.X  0.186
1998 Warnes KE, Morris MJ, Symonds ME, Phillips ID, Clarke IJ, Owens JA, McMillen IC. Effects of increasing gestation, cortisol and maternal undernutrition on hypothalamic Neuropeptide Y expression in the sheep fetus Journal of Neuroendocrinology. 10: 51-57. PMID 9510058 DOI: 10.1046/J.1365-2826.1998.00172.X  0.183
1981 Carson RS, Findlay JK, Clarke IJ, Burger HG. Estradiol, testosterone, and androstenedione in ovine follicular fluid during growth and atresia of ovarian follicles. Biology of Reproduction. 24: 105-13. PMID 7470536 DOI: 10.1095/BIOLREPROD24.1.105  0.183
2019 Henry MLE, Kemp S, Clarke IJ, Dunshea FR, Leury BJ. Perennial Ryegrass Alkaloids Increase Respiration Rate and Decrease Plasma Prolactin in Merino Sheep under Both Thermoneutral and Mild Heat Conditions. Toxins. 11. PMID 31430938 DOI: 10.3390/toxins11080479  0.183
2000 Tast A, Love RJ, Clarke IJ, Evans G. Effects of active and passive gonadotrophin-releasing hormone immunization on recognition and establishment of pregnancy in pigs. Reproduction, Fertility, and Development. 12: 277-82. PMID 11451018  0.182
2005 Phillips DJ, Jones KL, Clarke IJ, Scheerlinck JP, de Kretser DM. Activin A: from sometime reproductive factor to genuine cytokine. Veterinary Immunology and Immunopathology. 108: 23-7. PMID 16140391 DOI: 10.1016/j.vetimm.2005.08.011  0.181
2005 Dufourny L, Caraty A, Clarke IJ, Robinson JE, Skinner DC. Progesterone-receptive beta-endorphin and dynorphin B neurons in the arcuate nucleus project to regions of high gonadotropin-releasing hormone neuron density in the ovine preoptic area. Neuroendocrinology. 81: 139-49. PMID 15976512 DOI: 10.1159/000086527  0.181
2003 Iqbal J, Henry BA, Pompolo S, Rao A, Clarke IJ. Long-term alteration in bodyweight and food restriction does not affect the gene expression of either preproorexin or prodynorphin in the sheep. Neuroscience. 118: 217-26. PMID 12676151  0.181
2016 Clarke IJ, Bartolini D, Conductier G, Henry BA. Stress increases gonadotropin inhibitory hormone cell activity and input to gonadotropin releasing hormone cells in ewes. Endocrinology. en20161513. PMID 27611335 DOI: 10.1210/en.2016-1513  0.178
2022 Hart JE, Mohan S, Davies KG, Ferneyhough B, Clarke IJ, Hunt JA, Shnyder SD, Mundy CR, Howlett DR, Newton RP. Hexapeptides from mammalian inhibitory hormone hunt activate and inactivate nematode reproduction. Plos One. 17: e0278049. PMID 36454864 DOI: 10.1371/journal.pone.0278049  0.176
2020 Joy A, Dunshea FR, Leury BJ, DiGiacomo K, Clarke IJ, Zhang MH, Abhijith A, Osei-Amponsah R, Chauhan SS. Comparative Assessment of Thermotolerance in Dorper and Second-Cross (Poll Dorset/Merino × Border Leicester) Lambs. Animals : An Open Access Journal From Mdpi. 10. PMID 33419244 DOI: 10.3390/ani10122441  0.175
2016 Henry MLE, Kemp S, Clarke IJ, Dunshea FR, Leury BJ. Production and physiological effects of perennial ryegrass alkaloids under thermoneutral conditions in Merinos Animal Production Science. 56: 1629. DOI: 10.1071/AN14731  0.175
1993 Chen C, Zhang J, Israel JM, Clarke IJ, Vincent JD. Mechanism of the prolactin rebound after dopamine withdrawal in rat pituitary cells. The American Journal of Physiology. 265: E145-52. PMID 8393290 DOI: 10.1152/AJPENDO.1993.265.1.E145  0.175
2009 Qi Y, Oldfield BJ, Clarke IJ. Projections of RFamide-related peptide-3 neurones in the ovine hypothalamus, with special reference to regions regulating energy balance and reproduction. Journal of Neuroendocrinology. 21: 690-7. PMID 19500220 DOI: 10.1111/j.1365-2826.2009.01886.x  0.171
2011 Laker RC, Henry BA, Wadley GD, Clarke IJ, Canny BJ, McConell GK. Central infusion of leptin does not increase AMPK signaling in skeletal muscle of sheep. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 300: R511-8. PMID 21148475 DOI: 10.1152/ajpregu.00079.2010  0.169
2005 Anderson ST, Kusters DH, Clarke IJ, Pow DV, Curlewis JD. Expression of pituitary adenylate cyclase activating polypeptide type 1 receptor (PAC1R) in the ewe hypothalamus: distribution and colocalization with tyrosine hydroxylase-immunoreactive neurones. Journal of Neuroendocrinology. 17: 298-305. PMID 15869565 DOI: 10.1111/j.1365-2826.2005.01305.x  0.169
2008 Scott CJ, Clarke IJ, Tilbrook AJ. The effect of testosterone and season on prodynorphin messenger RNA expression in the preoptic area-hypothalamus of the ram. Domestic Animal Endocrinology. 34: 440-50. PMID 18308503 DOI: 10.1016/j.domaniend.2008.01.001  0.169
2000 Cowley MA, Chen C, Clarke IJ. Estrogen transiently increases delayed rectifier, voltage-dependent potassium currents in ovine gonadotropes. Neuroendocrinology. 69: 254-60. PMID 10207277 DOI: 10.1159/000054426  0.168
2015 Hetz JA, Menzies BR, Shaw G, Rao A, Clarke IJ, Renfree MB. Growth axis maturation is linked to nutrition, growth and developmental rate. Molecular and Cellular Endocrinology. 411: 38-48. PMID 25896544 DOI: 10.1016/J.Mce.2015.04.009  0.166
1982 Parr RA, Cumming IA, Clarke IJ. Effects of maternal nutrition and plasma progesterone concentrations on survival and growth of the sheep embryo in early gestation The Journal of Agricultural Science. 98: 39-46. DOI: 10.1017/S0021859600041083  0.164
1989 Thomas GB, Cummins JT, Smythe GA, Gleeson RM, Dow RC, Fink G, Clarke IJ. Concentrations of dopamine and noradrenaline in hypophysial portal blood in the sheep and the rat Journal of Endocrinology. 121: 141-147. PMID 2715753 DOI: 10.1677/Joe.0.1210141  0.163
2014 Lee TK, Clarke IJ, St John J, Young IR, Leury BL, Rao A, Andrews ZB, Henry BA. High cortisol responses identify propensity for obesity that is linked to thermogenesis in skeletal muscle. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 35-44. PMID 24022403 DOI: 10.1096/fj.13-238345  0.161
2010 Soga T, Wong DW, Clarke IJ, Parhar IS. Citalopram (antidepressant) administration causes sexual dysfunction in male mice through RF-amide related peptide in the dorsomedial hypothalamus. Neuropharmacology. 59: 77-85. PMID 20381503 DOI: 10.1016/j.neuropharm.2010.03.018  0.16
2014 Soga T, Kitahashi T, Clarke IJ, Parhar IS. Gonadotropin-inhibitory hormone promoter-driven enhanced green fluorescent protein expression decreases during aging in female rats. Endocrinology. 155: 1944-55. PMID 24605826 DOI: 10.1210/en.2013-1786  0.16
2010 Turner AI, Rivalland ET, Clarke IJ, Tilbrook AJ. Stressor specificity of sex differences in hypothalamo-pituitary-adrenal axis activity: cortisol responses to exercise, endotoxin, wetting, and isolation/restraint stress in gonadectomized male and female sheep. Endocrinology. 151: 4324-31. PMID 20668025 DOI: 10.1210/en.2010-0234  0.159
1987 Draincourt MA, Fry RC, Clarke IJ, Cahill LP. Follicular growth and regression during the 8 days after hypophysectomy in sheep. Journal of Reproduction and Fertility. 79: 635-41. PMID 3572892 DOI: 10.1530/JRF.0.0790635  0.158
2000 Scott CJ, Tilbrook AJ, Simmons DM, Rawson JA, Chu S, Fuller PJ, Ing NH, Clarke IJ. The distribution of cells containing estrogen receptor-alpha (ERalpha) and ERbeta messenger ribonucleic acid in the preoptic area and hypothalamus of the sheep: comparison of males and females. Endocrinology. 141: 2951-62. PMID 10919284 DOI: 10.1210/endo.141.8.7622  0.157
2011 Ehrenkranz J, Fualal J, Ndizihiwe A, Clarke I, Alder S. Neonatal age and point of careTSH testing in the monitoring of iodine deficiency disorders: findings from western Uganda. Thyroid : Official Journal of the American Thyroid Association. 21: 183-8. PMID 21186951 DOI: 10.1089/Thy.2009.0358  0.157
2000 Chen C, Xu R, Clarke IJ, Ruan M, Loneragan K, Roh SG. Diverse intracellular signalling systems used by growth hormone-releasing hormone in regulating voltage-gated Ca2+ or K channels in pituitary somatotropes. Immunology and Cell Biology. 78: 356-68. PMID 10947860 DOI: 10.1046/j.1440-1711.2000.00917.x  0.156
1996 Chen C, Wu D, Clarke IJ. Signal transduction systems employed by synthetic GH-releasing peptides in somatotrophs. The Journal of Endocrinology. 148: 381-6. PMID 8778215 DOI: 10.1677/JOE.0.1480381  0.155
2017 Hart JE, Clarke IJ, Risbridger GP, Ferneyhough B, Vega-Hernández M. Mysterious inhibitory cell regulator investigated and found likely to be secretogranin II related. Peerj. 5: e3833. PMID 29043108 DOI: 10.7717/peerj.3833  0.153
2004 Broadbear JH, Hutton LC, Clarke IJ, Canny BJ. Sex differences in the pituitary-adrenal response following acute antidepressant treatment in sheep. Psychopharmacology. 171: 450-7. PMID 14634712 DOI: 10.1007/s00213-003-1613-9  0.153
2003 Pompolo S, Pereira A, Kaneko T, Clarke IJ. Seasonal changes in the inputs to gonadotropin-releasing hormone neurones in the ewe brain: an assessment by conventional fluorescence and confocal microscopy. Journal of Neuroendocrinology. 15: 538-45. PMID 12694380  0.152
2013 Clarke SD, Clarke IJ, Rao A, Evans RG, Henry BA. Differential effects of acute and chronic estrogen treatment on thermogenic and metabolic pathways in ovariectomized sheep. Endocrinology. 154: 184-92. PMID 23183185 DOI: 10.1210/en.2012-1758  0.152
1991 Giraud AS, Clarke IJ, Rundle SE, Parker LM, Funder JW, Simpson RJ, Smith AI. Distribution, Isolation and Sequence Analysis of the C-Terminal Heptapeptide of Pro-Enkephalin A (YGGFMRF) from the Ovine Median Eminence. Journal of Neuroendocrinology. 3: 215-220. PMID 19215524 DOI: 10.1111/J.1365-2826.1991.Tb00265.X  0.152
1996 Phillips ID, Simonetta G, Owens JA, Robinson JS, Clarke IJ, McMillen IC. Placental restriction alters the functional development of the pituitary-adrenal axis in the sheep fetus during late gestation. Pediatric Research. 40: 861-866. PMID 8947963 DOI: 10.1203/00006450-199612000-00014  0.151
2016 Enriori PJ, Chen W, Garcia-Rudaz MC, Grayson BE, Evans AE, Comstock SM, Gebhardt U, Müller HL, Reinehr T, Henry BA, Brown RD, Bruce CR, Simonds SE, Litwak SA, McGee SL, ... ... Clarke IJ, et al. α-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors. Molecular Metabolism. 5: 807-22. PMID 27688995 DOI: 10.1016/J.Molmet.2016.07.009  0.151
1992 McCarthy RN, Jeffcott LB, Funder JW, Fullerton M, Clarke IJ. Plasma beta-endorphin and adrenocorticotrophin in young horses in training. Australian Veterinary Journal. 68: 359-61. PMID 1663738 DOI: 10.1111/J.1751-0813.1991.TB00736.X  0.151
2002 Gatford KL, Clarke IJ, De Blasio MJ, McMillen IC, J S Robinson, Owens JA. Perinatal growth and plasma GH profiles in adolescent and adult sheep. The Journal of Endocrinology. 173: 151-9. PMID 11927394 DOI: 10.1677/Joe.0.1730151  0.151
2007 Goodman RL, Lehman MN, Smith JT, Coolen LM, de Oliveira CV, Jafarzadehshirazi MR, Pereira A, Iqbal J, Caraty A, Ciofi P, Clarke IJ. Kisspeptin neurons in the arcuate nucleus of the ewe express both dynorphin A and neurokinin B. Endocrinology. 148: 5752-60. PMID 17823266 DOI: 10.1210/En.2007-0961  0.15
2008 Henry BA, Dunshea FR, Gould M, Clarke IJ. Profiling postprandial thermogenesis in muscle and fat of sheep and the central effect of leptin administration. Endocrinology. 149: 2019-26. PMID 18162524 DOI: 10.1210/en.2007-1311  0.15
2009 Qi Y, Namavar MR, Iqbal J, Oldfield BJ, Clarke IJ. Characterization of the projections to the hypothalamic paraventricular and periventricular nuclei in the female sheep brain, using retrograde tracing and immunohistochemistry. Neuroendocrinology. 90: 31-53. PMID 19478473 DOI: 10.1159/000221304  0.15
2003 Scott CJ, Clarke IJ, Tilbrook AJ. Neuronal inputs from the hypothalamus and brain stem to the medial preoptic area of the ram: neurochemical correlates and comparison to the ewe. Biology of Reproduction. 68: 1119-33. PMID 12606458 DOI: 10.1095/biolreprod.102.010595  0.149
1975 Clarke IJ, McDonald MF. Influence of gonadotrophic stimulation on progestagen synchronisation in the ewe New Zealand Journal of Agricultural Research. 18: 19-22. DOI: 10.1080/00288233.1975.10430382  0.149
1981 Clarke IJ, Burman K, Funder JW, Findlay JK. Estrogen receptors in the neuroendocrine tissues of the ewe in relation to breed, season, and stage of the estrous cycle. Biology of Reproduction. 24: 323-31. PMID 7194123 DOI: 10.1095/BIOLREPROD24.2.323  0.149
1977 Clarke IJ. The sexual behaviour of prenatally androgenized ewes observed in the field. Journal of Reproduction and Fertility. 49: 311-5. PMID 557554 DOI: 10.1530/JRF.0.0490311  0.148
2008 Qi Y, Iqbal J, Oldfield BJ, Clarke IJ. Neural connectivity in the mediobasal hypothalamus of the sheep brain. Neuroendocrinology. 87: 91-112. PMID 17938564 DOI: 10.1159/000109944  0.148
2010 Henry BA, Blache D, Rao A, Clarke IJ, Maloney SK. Disparate effects of feeding on core body and adipose tissue temperatures in animals selectively bred for Nervous or Calm temperament. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 299: R907-17. PMID 20573991 DOI: 10.1152/ajpregu.00809.2009  0.148
1982 Findlay JK, Clarke IJ, Swaney J, Colvin N, Doughton B. Oestrogen receptors and protein synthesis in caruncular and intercaruncular endometrium of sheep before implantation. Journal of Reproduction and Fertility. 64: 329-39. PMID 7069654 DOI: 10.1530/JRF.0.0640329  0.147
2000 Scott CJ, Tilbrook AJ, Simmons DM, Rawson JA, Chu S, Fuller PJ, Ing NH, Clarke IJ. The Distribution of Cells Containing Estrogen Receptor-α (ERα) and ERβ Messenger Ribonucleic Acid in the Preoptic Area and Hypothalamus of the Sheep: Comparison of Males and Females. Endocrinology. 141: 2951-2962. PMID 28201083 DOI: 10.1210/En.141.8.2951  0.145
2011 Sabin MA, Yau SW, Russo VC, Clarke IJ, Dunshea FR, Chau J, Cox M, Werther GA. Dietary monounsaturated fat in early life regulates IGFBP2: implications for fat mass accretion and insulin sensitivity. Obesity (Silver Spring, Md.). 19: 2374-81. PMID 21436793 DOI: 10.1038/oby.2011.55  0.145
1989 Horton RJ, Clarke IJ. Lack of an effect of morphine or naloxone on the oestrogen-induced LH surge in anoestrous ewes. The Journal of Endocrinology. 119: 89-93. PMID 3193051 DOI: 10.1677/JOE.0.1190089  0.145
2017 Li L, Yang G, Liao G, Mei J, Li L, Wang C, Yuan Y, Shi Y, Liu J, Zhong Z, Cheng J, Lu Y, Clarke IJ, Chen Y. Glucocorticoid treatment facilitates development of a metabolic syndrome in ovariectomized Macaca Mulatta fed a high fat diet. Steroids. PMID 28988119 DOI: 10.1016/j.steroids.2017.09.005  0.145
1995 Shen PJ, Smith AI, Evans RG, Clarke IJ. Effects of ovarian steroids on hypothalamic opioid receptor subtypes in ovariectomized ewes: regional changes in density and affinity. The Journal of Endocrinology. 145: 559-67. PMID 7636439 DOI: 10.1677/JOE.0.1450559  0.144
2002 Clarke I, Moore L, Veldhuis J. Intensive direct cavernous sinus sampling identifies high-frequency, nearly random patterns of FSH secretion in ovariectomized ewes: combined appraisal by RIA and bioassay. Endocrinology. 143: 117-29. PMID 11751600 DOI: 10.1210/endo.143.1.8644  0.144
1988 Fry RC, Clarke IJ, Cummins JT, Bindon BM, Piper LR, Cahill LP. Induction of ovulation in chronically hypophysectomized Booroola ewes. Journal of Reproduction and Fertility. 82: 711-5. PMID 3361505 DOI: 10.1530/JRF.0.0820711  0.143
2012 Clarke SD, Clarke IJ, Rao A, Cowley MA, Henry BA. Sex differences in the metabolic effects of testosterone in sheep. Endocrinology. 153: 123-31. PMID 22128020 DOI: 10.1210/en.2011-1634  0.141
1995 Willoughby JO, Oliver JR, Fletcher TP, Clarke IJ. Distribution of somatostatin immunoreactivity in sheep hypothalamus: a comparison with that of the rat. Archives of Histology and Cytology. 58: 31-6. PMID 7612359 DOI: 10.1679/AOHC.58.31  0.141
2014 Yau SW, Henry BA, Russo VC, McConell GK, Clarke IJ, Werther GA, Sabin MA. Leptin enhances insulin sensitivity by direct and sympathetic nervous system regulation of muscle IGFBP-2 expression: evidence from nonrodent models. Endocrinology. 155: 2133-43. PMID 24654786 DOI: 10.1210/en.2013-2099  0.14
2001 Iqbal J, Pompolo S, Dumont LM, Wu CS, Mountjoy KG, Henry BA, Clarke IJ. Long-term alterations in body weight do not affect the expression of melanocortin receptor-3 and -4 mRNA in the ovine hypothalamus. Neuroscience. 105: 931-40. PMID 11530231  0.138
2012 Adler ES, Hollis JH, Clarke IJ, Grattan DR, Oldfield BJ. Neurochemical characterization and sexual dimorphism of projections from the brain to abdominal and subcutaneous white adipose tissue in the rat. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 15913-21. PMID 23136429 DOI: 10.1523/JNEUROSCI.2591-12.2012  0.132
2017 Oheim R, Simon MJ, Steiner M, Vettorazzi E, Barvencik F, Ignatius A, Amling M, Clarke IJ, Pogoda P, Beil FT. Sheep model for osteoporosis: The effects of peripheral hormone therapy on centrally induced systemic bone loss in an osteoporotic sheep model. Injury. PMID 28237183 DOI: 10.1016/J.Injury.2017.02.009  0.132
1998 Smith AI, Clarke IJ, Lew RA. Post-secretory processing of peptide signals: a novel mechanism for the regulation of peptide hormone receptors. Biochemical Society Transactions. 25: 1011-4. PMID 9388592 DOI: 10.1042/BST0251011  0.131
2012 Oheim R, Beil FT, Barvencik F, Egermann M, Amling M, Clarke IJ, Pogoda P. Targeting the lateral but not the third ventricle induces bone loss in ewe: an experimental approach to generate an improved large animal model of osteoporosis. The Journal of Trauma and Acute Care Surgery. 72: 720-6. PMID 22491560 DOI: 10.1097/Ta.0B013E318238B3Bd  0.13
2002 Pompolo S, Scott CJ, Clarke IJ. Selective regulation of glutamic decarboxylase isoform 65, but not isoform 67, in the bed nucleus of the stria terminalis and the preoptic area of the ewe brain across the estrous cycle. Endocrinology. 143: 544-50. PMID 11796509 DOI: 10.1210/endo.143.2.8610  0.13
1994 Gaylinn BD, Lyons CE, Zysk JR, Clarke IJ, Thorner MO. Photoaffinity cross-linking to the pituitary receptor for growth hormone-releasing factor. Endocrinology. 135: 950-5. PMID 8070391 DOI: 10.1210/ENDO.135.3.8070391  0.129
2001 Rawson JA, Scott CJ, Pereira A, Jakubowska A, Clarke IJ. Noradrenergic projections from the A1 field to the preoptic area in the brain of the ewe and Fos responses to oestrogen in the A1 cells. Journal of Neuroendocrinology. 13: 129-38. PMID 11168838 DOI: 10.1046/j.1365-2826.2001.00588.x  0.127
1986 Slater AJ, Gude N, Clarke IJ, Walters WAW. Haemodynamic changes and left ventricular performance during high-dose oestrogen administration to male transsexuals British Journal of Obstetrics and Gynaecology. 93: 532-538. PMID 3730322 DOI: 10.1111/j.1471-0528.1986.tb07949.x  0.126
2020 Joy A, Dunshea FR, Leury BJ, DiGiacomo K, Clarke IJ, Zhang M, Abhijith A, Osei-Amponsah R, Chauhan SS. Differences in Thermoregulatory Responses between Dorper and Second Cross Lambs to Heat Stress Challenges Proceedings. 36: 155. DOI: 10.3390/proceedings2019036155  0.125
1979 Clarke I. Induction of male behaviour in ovariectomized ewes and ovariectomized-androgenized ewes chronically implanted with oestradiol-17β or testosterone Animal Reproduction Science. 1: 305-312. DOI: 10.1016/0378-4320(79)90016-2  0.125
2003 Scott CJ, Mariani M, Clarke IJ, Tilbrook AJ. 99. The effect of testosterone and season on preproenkephalin mRNA expression in the pre-optic area - hypothalamus of the ram Reproduction, Fertility and Development. 15: 99. DOI: 10.1071/SRB03AB99  0.124
1997 Mansour VM, Clarke IJ, Smith AI. The characterization, localization and regulation of endothelin in ovine pars intermedia. Regulatory Peptides. 70: 55-65. PMID 9250582 DOI: 10.1016/S0167-0115(97)00018-9  0.124
2013 Oheim R, Beil FT, Köhne T, Wehner T, Barvencik F, Ignatius A, Amling M, Clarke IJ, Pogoda P. Sheep model for osteoporosis: sustainability and biomechanical relevance of low turnover osteoporosis induced by hypothalamic-pituitary disconnection. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 31: 1067-74. PMID 23440966 DOI: 10.1002/Jor.22327  0.124
1998 Scott CJ, Rawson JA, Pereira AM, Clarke IJ. The distribution of estrogen receptors in the brainstem of female sheep. Neuroscience Letters. 241: 29-32. PMID 9502208 DOI: 10.1016/S0304-3940(97)00963-4  0.123
2012 Clarke IJ, Campbell R, Smith JT, Prevot V, Wray S. Neuroendocrine control of reproduction Handbook of Neuroendocrinology. 197-235. DOI: 10.1016/B978-0-12-375097-6.10009-5  0.122
1992 Clarke I, Tilbrook A. Influence of non-photoperiodic environmental factors on reproduction in domestic animals Animal Reproduction Science. 28: 219-228. DOI: 10.1016/0378-4320(92)90108-P  0.122
2007 Ferrari JM, Pluske JR, Miller DW, Clarke IJ, Dunshea FR. Oxytocin reduces the stress of weaning and increases gastric expression of ghrelin and leptin in neonatal pigs The Faseb Journal. 21. DOI: 10.1096/FASEBJ.21.5.A320-B  0.121
2012 Beil FT, Oheim R, Barvencik F, Hissnauer TN, Pestka JM, Ignatius A, Rueger JM, Schinke T, Clarke IJ, Amling M, Pogoda P. Low turnover osteoporosis in sheep induced by hypothalamic-pituitary disconnection. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 30: 1254-62. PMID 22234948 DOI: 10.1002/Jor.22066  0.12
2010 Clarke I. Endword Psychosis and Spirituality: Consolidating the New Paradigm: Second Edition. 249-251. DOI: 10.1002/9780470970300.ch20  0.12
2019 Fuller-Jackson J, Dordevic A, Clarke IJ, Truby H, Henry BA. Sex and menstrual cycle modulate cold- and meal-induced brown adipose tissue activity in humans Obesity Research & Clinical Practice. 13: 270-271. DOI: 10.1016/J.ORCP.2018.11.100  0.12
2000 Xu R, Clarke IJ, Chen S, Chen C. Growth hormone-releasing hormone decreases voltage-gated potassium currents in GH4C1 cells. Journal of Neuroendocrinology. 12: 147-57. PMID 10718910 DOI: 10.1046/j.1365-2826.2000.00430.x  0.119
2010 Pereira A, Rawson J, Jakubowska A, Clarke IJ. Estradiol-17beta-responsive A1 and A2 noradrenergic cells of the brain stem project to the bed nucleus of the stria terminalis in the ewe brain: a possible route for regulation of gonadotropin releasing hormone cells. Neuroscience. 165: 758-73. PMID 19857554 DOI: 10.1016/j.neuroscience.2009.10.027  0.119
2021 Yeo GSH, Moro Chao DH, Siegert AM, Koerperich ZM, Ericson MD, Simonds SE, Larson CM, Luquet S, Clarke I, Sharma S, Clément K, Cowley MA, Haskell-Luevano C, Van Der Ploeg L, Adan RAH. The melanocortin pathway and energy homeostasis: From discovery to obesity therapy. Molecular Metabolism. 101206. PMID 33684608 DOI: 10.1016/j.molmet.2021.101206  0.118
2015 Gugusheff JR, Bae SE, Rao A, Clarke IJ, Poston L, Taylor PD, Coen CW, Muhlhausler BS. Sex and age-dependent effects of a maternal junk food diet on the mu-opioid receptor in rat offspring. Behavioural Brain Research. PMID 26718219 DOI: 10.1016/J.Bbr.2015.12.027  0.117
2008 Clarke IJ. Models of 'obesity' in large animals and birds. Frontiers of Hormone Research. 36: 107-17. PMID 18230898 DOI: 10.1159/0000115359  0.117
2020 Chauhan SS, Zhang M, Joy A, Osei-Amponsah R, Leury BJ, Warner RD, Clarke IJ, Dunshea FR. Adaptive and Productive Sheep Breed for Changing Climate Proceedings. 36: 137. DOI: 10.3390/proceedings2019036137  0.116
2020 Fuller-Jackson JP, Dordevic AL, Clarke IJ, Henry BA. Effect of sex and sex steroids on brown adipose tissue heat production in humans. European Journal of Endocrinology. PMID 32508310 DOI: 10.1530/EJE-20-0184  0.116
2014 Chauhan SS, Celi P, Leury BJ, Clarke IJ, Dunshea FR. Dietary antioxidants at supranutritional doses improve oxidative status and reduce the negative effects of heat stress in sheep. Journal of Animal Science. 92: 3364-74. PMID 24894002 DOI: 10.2527/jas.2014-7714  0.115
2004 Keenan DM, Alexander S, Irvine CH, Clarke I, Scott C, Turner A, Tilbrook AJ, Canny BJ, Veldhuis JD. Reconstruction of in vivo time-evolving neuroendocrine dose-response properties unveils admixed deterministic and stochastic elements. Proceedings of the National Academy of Sciences of the United States of America. 101: 6740-5. PMID 15090645 DOI: 10.1073/Pnas.0300619101  0.115
2011 Henry BA, Andrews ZB, Rao A, Clarke IJ. Central leptin activates mitochondrial function and increases heat production in skeletal muscle. Endocrinology. 152: 2609-18. PMID 21558317 DOI: 10.1210/en.2011-0143  0.114
2009 Skilton RJ, Cutcliffen LT, Barlow D, Wang Y, Salim O, Lambden PR, Clarke IN. Penicillin induced persistence in Chlamydia trachomatis: high quality time lapse video analysis of the developmental cycle. Plos One. 4: e7723. PMID 19893744 DOI: 10.1371/journal.pone.0007723  0.112
2013 Hewagalamulage SD, Clarke IJ, Henry BA. Animals selected for high cortisol responsiveness have reduced melanocortin signalling and increased propensity to obesity Obesity Research & Clinical Practice. 7: e64. DOI: 10.1016/J.ORCP.2013.12.620  0.112
1994 Chen C, Heyward P, Zhang J, Wu D, Clarke IJ. Voltage-dependent potassium currents in ovine somatotrophs and their function in growth hormone secretion. Neuroendocrinology. 59: 1-9. PMID 8145891 DOI: 10.1159/000126631  0.112
2006 Pogoda P, Egermann M, Schnell JC, Priemel M, Schilling AF, Alini M, Schinke T, Rueger JM, Schneider E, Clarke I, Amling M. Leptin inhibits bone formation not only in rodents, but also in sheep. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 21: 1591-9. PMID 16995814 DOI: 10.1359/Jbmr.060709  0.109
2017 Henry BA, Pope M, Birtwistle M, Loughnan R, Alagal R, Fuller-Jackson JP, Perry V, Budge H, Clarke IJ, Symonds ME. Ontogeny and thermogenic role for sternal fat in female sheep. Endocrinology. PMID 28431116 DOI: 10.1210/en.2017-00081  0.109
2015 Yau SW, Russo VC, Clarke IJ, Dunshea FR, Werther GA, Sabin MA. IGFBP-2 inhibits adipogenesis and lipogenesis in human visceral, but not subcutaneous, adipocytes. International Journal of Obesity (2005). 39: 770-81. PMID 25370576 DOI: 10.1038/ijo.2014.192  0.107
1978 Van Look PF, Clarke IJ, Davidson WG, Scaramuzzi RJ. Ovulation and lambing rates in ewes actively immunized against androstenedione. Journal of Reproduction and Fertility. 53: 129-30. PMID 565406 DOI: 10.1530/JRF.0.0530129  0.104
2001 Clarke IJ. Sex and season are major determinants of voluntary food intake in sheep. Reproduction, Fertility, and Development. 13: 577-82. PMID 11999308  0.103
1995 Heyward PM, Chen C, Clarke IJ. Inward membrane currents and electrophysiological responses to GnRH in ovine gonadotropes. Neuroendocrinology. 61: 609-21. PMID 7544876 DOI: 10.1159/000126887  0.101
2019 Osei-Amponsah R, Chauhan SS, Leury BJ, Cheng L, Cullen B, Clarke IJ, Dunshea FR. Genetic Selection for Thermotolerance in Ruminants. Animals : An Open Access Journal From Mdpi. 9. PMID 31717903 DOI: 10.3390/ani9110948  0.098
1977 Clarke IJ, Scaramuzzi RJ, Short RV. Sexual differentiation of the brain: endocrine and behavioural responses of androgenized ewes to oestrogen. The Journal of Endocrinology. 71: 175-6. PMID 978117 DOI: 10.1677/JOE.0.0710175  0.097
2009 Sorimachi T, Clarke IC, Williams PA, Gustafson A, Yamamoto K. Third-body abrasive wear challenge of 32 mm conventional and 44 mm highly crosslinked polyethylene liners in a hip simulator model. Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine. 223: 607-23. PMID 19623913 DOI: 10.1243/09544119JEIM562  0.096
2016 Maiden MJ, Chapman MJ, Torpy DJ, Kuchel TR, Clarke IJ, Nash CH, Fraser JD, Ludbrook GL. Triiodothyronine Administration in a Model of Septic Shock: A Randomized Blinded Placebo-Controlled Trial. Critical Care Medicine. PMID 26963323 DOI: 10.1097/CCM.0000000000001644  0.096
1994 Chen C, Vincent JD, Clarke IJ. Ion channels and the signal transduction pathways in the regulation of growth hormone secretion. Trends in Endocrinology and Metabolism: Tem. 5: 227-33. PMID 18407212 DOI: 10.1016/1043-2760(94)P3080-Q  0.094
2018 Fuller-Jackson JP, Clarke IJ, Rao A, Henry BA. Exercise counteracts the homeostatic decrease in thermogenesis caused by caloric restriction in sheep. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201701504R. PMID 29455575 DOI: 10.1096/fj.201701504R  0.094
1985 Wright PJ, Geytenbeek PE, O'Shea JD, Williams AH, Clarke IJ. The improvement of reproductive efficiency in post-partum ewes: some basic and some applied studies Australian Veterinary Journal. 62: 143-145. DOI: 10.1111/J.1751-0813.1985.TB13924.X  0.094
1985 Berg SJ, Balant LP, Clarke I, Fairfax AJ. Slow release choline theophyllinate (Sabidal SR 270) in chronic asthma. British Journal of Clinical Pharmacology. 20: 89-90. PMID 4027142  0.093
2005 Richardson HA, Clarke IC, Williams P, Donaldson T, Oonishi H. Precision and accuracy in ceramic-on-ceramic wear analyses: influence of simulator test duration. Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine. 219: 401-5. PMID 16312099 DOI: 10.1243/095441105X34428  0.092
1993 McCarthy R, Jeffcott L, Clarke I. Preliminary studies on the use of plasma β-endorphin in horses as an indicator of stress and pain Journal of Equine Veterinary Science. 13: 216-219. DOI: 10.1016/S0737-0806(06)81015-4  0.09
2020 Joy A, Dunshea FR, Leury BJ, Clarke IJ, DiGiacomo K, Chauhan SS. Resilience of Small Ruminants to Climate Change and Increased Environmental Temperature: A Review. Animals : An Open Access Journal From Mdpi. 10. PMID 32429527 DOI: 10.3390/ani10050867  0.09
1997 Bielaszewska M, Clarke I, Karmali MA, Petric M. Localization of intravenously administered verocytotoxins (shiga-like toxins) 1 and 2 in rabbits immunized with homologous and heterologous toxoids and toxin subunits Infection and Immunity. 65: 2509-2516. PMID 9199412 DOI: 10.1128/Iai.65.7.2509-2516.1997  0.089
2009 Haylor JL, Parker E, Risbridger GP, Beale D, Brown BL, Dobson PR, Clarke IJ, Hart JE. Inhibition of compensatory renal growth by the N-terminus of a sheep-derived peptide. Regulatory Peptides. 152: 48-53. PMID 19028530 DOI: 10.1016/j.regpep.2008.10.011  0.088
1995 Chen C, Clarke IJ. Modulation of Ca2+ influx in the ovine somatotroph by growth hormone-releasing factor. The American Journal of Physiology. 268: E204-12. PMID 7864095 DOI: 10.1152/AJPENDO.1995.268.2.E204  0.087
2017 Cottrell JJ, Liu F, Wan S, Wijesiriwardana UA, DiGiacomo K, Kelly F, Celi P, Leury B, Clarke IJ, Dunshea FR. The effect of heat stress on respiratory alkalosis, blood acid base balance and insulin sensitivity in cinnamon supplemented pigs Animal Production Science. 57: 2415. DOI: 10.1071/ANV57N12AB043  0.087
2008 Brown SS, Green DD, Pezzotti G, Donaldson TK, Clarke IC. Possible triggers for phase transformation in zirconia hip balls. Journal of Biomedical Materials Research. Part B, Applied Biomaterials. 85: 444-52. PMID 18000870 DOI: 10.1002/Jbm.B.30964  0.086
2019 Howlett DR, Clarke IJ, Newton RP, Hart JE. Epitope mapping of an uncertain endogenous antigen implies secretogranin II peptide splicing. F1000research. 8: 1732. PMID 32399184 DOI: 10.12688/f1000research.20633.2  0.086
2003 Clarke I, Green DD, Pezzotti G, Sakakura S, Ben-Nissan B. The bio-lubrication phenomena (proteins) may control the wear performance of zirconia hip joints Ceramic Transactions. 147: 155-167.  0.085
2010 Henry BA, Clarke IJ. Food Intake and Stress, Non-Human Encyclopedia of Stress. 82-87. DOI: 10.1016/B978-012373947-6.00165-3  0.084
2012 Clarke SD, Lee K, Andrews ZB, Bischof R, Fahri F, Evans RG, Clarke IJ, Henry BA. Postprandial heat production in skeletal muscle is associated with altered mitochondrial function and altered futile calcium cycling. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 303: R1071-9. PMID 23019214 DOI: 10.1152/ajpregu.00036.2012  0.084
2011 Persaud A, Alberts P, Hayes M, Guettler S, Clarke I, Sicheri F, Dirks P, Ciruna B, Rotin D. Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function. The Embo Journal. 30: 3259-73. PMID 21765395 DOI: 10.1038/Emboj.2011.234  0.084
2018 Shorakae S, Jona E, de Courten B, Lambert GW, Lambert EA, Phillips SE, Clarke IJ, Teede HJ, Henry BA. Brown adipose tissue thermogenesis in polycystic ovary syndrome. Clinical Endocrinology. PMID 30548504 DOI: 10.1111/cen.13913  0.084
1995 Chen C, Clarke IJ. Effects of growth hormone-releasing peptide-2 (GHRP-2) on membrane Ca2+ permeability in cultured ovine somatotrophs. Journal of Neuroendocrinology. 7: 179-86. PMID 7606243 DOI: 10.1111/j.1365-2826.1995.tb00745.x  0.082
2011 Reed DL, Currier RW, Walton SF, Conrad M, Sullivan SA, Carlton JM, Read TD, Severini A, Tyler S, Eberle R, Johnson WE, Silvestri G, Clarke IN, Lagergård T, Lukehart SA, et al. The evolution of infectious agents in relation to sex in animals and humans: brief discussions of some individual organisms. Annals of the New York Academy of Sciences. 1230: 74-107. PMID 21824167 DOI: 10.1111/J.1749-6632.2011.06133.X  0.082
2010 Unemo M, Seth-Smith HM, Cutcliffe LT, Skilton RJ, Barlow D, Goulding D, Persson K, Harris SR, Kelly A, Bjartling C, Fredlund H, Olcén P, Thomson NR, Clarke IN. The Swedish new variant of Chlamydia trachomatis: genome sequence, morphology, cell tropism and phenotypic characterization. Microbiology (Reading, England). 156: 1394-404. PMID 20093289 DOI: 10.1099/mic.0.036830-0  0.082
2013 Dunshea FR, Leury BJ, Fahri F, Digiacomo K, Hung A, Chauhan S, Clarke IJ, Collier R, Little S, Baumgard L, Gaughan JB. Amelioration of thermal stress impacts in dairy cows Animal Production Science. 53: 965-975. DOI: 10.1071/An12384  0.082
2009 Bowsher JG, Clarke IC, Williams PA, Donaldson TK. What is a "normal" wear pattern for metal-on-metal hip bearings? Journal of Biomedical Materials Research. Part B, Applied Biomaterials. 91: 297-308. PMID 19582850 DOI: 10.1002/jbm.b.31403  0.08
2010 Manolea F, Chun J, Chen DW, Clarke I, Summerfeldt N, Dacks JB, Melançon P. Arf3 is activated uniquely at the trans-Golgi network by brefeldin A-inhibited guanine nucleotide exchange factors. Molecular Biology of the Cell. 21: 1836-49. PMID 20357002 DOI: 10.1091/Mbc.E10-01-0016  0.079
2006 Tateiwa T, Clarke IC, Shirasu H, Masaoka T, Shishido T, Yamamoto K. Effect of low protein concentration lubricants in hip simulators. Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association. 11: 204-11. PMID 16568395 DOI: 10.1007/s00776-005-0999-0  0.079
2014 Vanner RJ, Remke M, Gallo M, Selvadurai HJ, Coutinho F, Lee L, Kushida M, Head R, Morrissy S, Zhu X, Aviv T, Voisin V, Clarke ID, Li Y, Mungall AJ, et al. Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma. Cancer Cell. 26: 33-47. PMID 24954133 DOI: 10.1016/J.Ccr.2014.05.005  0.079
2010 Clarke IJ, Henry BA. Targeting energy expenditure in muscle as a means of combating obesity. Clinical and Experimental Pharmacology & Physiology. 37: 121-4. PMID 19650796 DOI: 10.1111/j.1440-1681.2009.05259.x  0.078
2010 Williams PA, Brown CM, Tsukamoto R, Clarke IC. Polyethylene wear debris produced in a knee simulator model: effect of crosslinking and counterface material. Journal of Biomedical Materials Research. Part B, Applied Biomaterials. 92: 78-85. PMID 19802834 DOI: 10.1002/jbm.b.31491  0.078
2010 Clarke IJ. The Nexus Between Metabolic and Reproductive Circuits in the Hypothalamus. Biology of Reproduction. 83: 47-47. DOI: 10.1093/BIOLREPROD/83.S1.47  0.077
2010 Maskiewicz VK, Williams PA, Prates SJ, Bowsher JG, Clarke IC. Characterization of protein degradation in serum-based lubricants during simulation wear testing of metal-on-metal hip prostheses. Journal of Biomedical Materials Research. Part B, Applied Biomaterials. 94: 429-40. PMID 20583304 DOI: 10.1002/jbm.b.31671  0.077
1977 Clarke I. The sexual and aggressive behaviour of normal and masculinized ewes chronically treated with oestradiol-17β (E2) or testosterone (T) Theriogenology. 8: 152. DOI: 10.1016/0093-691X(77)90114-5  0.076
2006 Tilbrook A, Rivalland E, Turner A, Pompolo S, Clarke I. Isolation/restraint stress in sheep activates projections to the preoptic area arising from the paraventricular nucleus but not those arising from the bed nucleus of the stria terminalis or the arcuate nucleus Frontiers in Neuroendocrinology. 27: 40-41. DOI: 10.1016/j.yfrne.2006.03.081  0.075
2008 Salim O, Skilton RJ, Lambden PR, Fane BA, Clarke IN. Behind the chlamydial cloak: the replication cycle of chlamydiaphage Chp2, revealed. Virology. 377: 440-5. PMID 18570973 DOI: 10.1016/J.Virol.2008.05.001  0.074
2004 Donaldson T, Williams P, Andrusak L, Sutton M, Clarke I. Effect of sterilization on the clinical wear of hylamer cups Transactions - 7th World Biomaterials Congress. 815.  0.074
2004 Singh SK, Hawkins C, Clarke ID, Squire JA, Bayani J, Hide T, Henkelman RM, Cusimano MD, Dirks PB. Identification of human brain tumour initiating cells. Nature. 432: 396-401. PMID 15549107 DOI: 10.1038/Nature03128  0.073
2009 Rastegar M, Hotta A, Pasceri P, Makarem M, Cheung AY, Elliott S, Park KJ, Adachi M, Jones FS, Clarke ID, Dirks P, Ellis J. MECP2 isoform-specific vectors with regulated expression for Rett syndrome gene therapy. Plos One. 4: e6810. PMID 19710912 DOI: 10.1371/Journal.Pone.0006810  0.073
2006 Tsukamoto R, Chen S, Asano T, Ogino M, Shoji H, Nakamura T, Clarke IC. Improved wear performance with crosslinked UHMWPE and zirconia implants in knee simulation. Acta Orthopaedica. 77: 505-11. PMID 16819693 DOI: 10.1080/17453670610046479  0.072
2008 Tsukamoto R, Williams PA, Clarke IC, Pezzotti G, Shoji H, Akagi M, Yamamoto K. Y-TZP zirconia run against highly crosslinked UHMWPE tibial inserts: knee simulator wear and phase-transformation studies. Journal of Biomedical Materials Research. Part B, Applied Biomaterials. 86: 145-53. PMID 18161824 DOI: 10.1002/Jbm.B.30999  0.072
2014 Herod MR, Salim O, Skilton RJ, Prince CA, Ward VK, Lambden PR, Clarke IN. Expression of the murine norovirus (MNV) ORF1 polyprotein is sufficient to induce apoptosis in a virus-free cell model. Plos One. 9: e90679. PMID 24599381 DOI: 10.1371/journal.pone.0090679  0.071
2005 Skipp P, Robinson J, O'Connor CD, Clarke IN. Shotgun proteomic analysis of Chlamydia trachomatis. Proteomics. 5: 1558-73. PMID 15838905 DOI: 10.1002/pmic.200401044  0.071
2006 Lehman M, Coolen L, de Oliveira C, Clarke I, Goodman R. Kisspeptin is co-localized in a subset of dynorphin neurons in the ovine arcuate nucleus Frontiers in Neuroendocrinology. 27: 73. DOI: 10.1016/j.yfrne.2006.03.152  0.071
2011 Otto PH, Clarke IN, Lambden PR, Salim O, Reetz J, Liebler-Tenorio EM. Infection of calves with bovine norovirus GIII.1 strain Jena virus: an experimental model to study the pathogenesis of norovirus infection. Journal of Virology. 85: 12013-21. PMID 21880760 DOI: 10.1128/JVI.05342-11  0.07
2007 Oliver SL, Wood E, Asobayire E, Wathes DC, Brickell JS, Elschner M, Otto P, Lambden PR, Clarke IN, Bridger JC. Serotype 1 and 2 bovine noroviruses are endemic in cattle in the United kingdom and Germany. Journal of Clinical Microbiology. 45: 3050-2. PMID 17596356 DOI: 10.1128/JCM.02015-06  0.07
2006 Akagi M, Asano T, Clarke IC, Niiyama N, Kyomoto M, Nakamura T, Hamanishi C. Wear and toughness of crosslinked polyethylene for total knee replacements: a study using a simulator and small-punch testing. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 24: 2021-7. PMID 16894591 DOI: 10.1002/Jor.20223  0.069
2009 Ishida T, Clarke IC, Donaldson TK, Shirasu H, Shishido T, Yamamoto K. Comparing ceramic-metal to metal-metal total hip replacements--a simulator study of metal wear and ion release in 32- and 38-mm bearings. Journal of Biomedical Materials Research. Part B, Applied Biomaterials. 91: 887-96. PMID 19598291 DOI: 10.1002/jbm.b.31471  0.068
1980 Clarke I. Control of ovulation Animal Reproduction Science. 3: 169-170. DOI: 10.1016/0378-4320(80)90046-9  0.067
2018 Lee NJ, Ali N, Zhang L, Qi Y, Clarke I, Enriquez RF, Brzozowska M, Lee IC, Rogers MJ, Laybutt DR, Center JR, Baldock PA, Herzog H. Osteoglycin, a novel coordinator of bone and glucose homeostasis. Molecular Metabolism. PMID 29799418 DOI: 10.1016/j.molmet.2018.05.004  0.067
2008 Tsukamoto R, Williams PA, Shoji H, Hirakawa K, Yamamoto K, Tsukamoto M, Clarke IC. Wear of sequentially enhanced 9-Mrad polyethylene in 10 million cycle knee simulation study. Journal of Biomedical Materials Research. Part B, Applied Biomaterials. 86: 119-24. PMID 18098196 DOI: 10.1002/jbm.b.30996  0.066
2007 Ward VK, McCormick CJ, Clarke IN, Salim O, Wobus CE, Thackray LB, Virgin HW, Lambden PR. Recovery of infectious murine norovirus using pol II-driven expression of full-length cDNA. Proceedings of the National Academy of Sciences of the United States of America. 104: 11050-5. PMID 17581883 DOI: 10.1073/Pnas.0700336104  0.066
2011 Agnihotri S, Wolf A, Munoz DM, Smith CJ, Gajadhar A, Restrepo A, Clarke ID, Fuller GN, Kesari S, Dirks PB, McGlade CJ, Stanford WL, Aldape K, Mischel PS, Hawkins C, et al. A GATA4-regulated tumor suppressor network represses formation of malignant human astrocytomas. The Journal of Experimental Medicine. 208: 689-702. PMID 21464220 DOI: 10.1084/Jem.20102099  0.065
2007 Asano T, Akagi M, Clarke IC, Masuda S, Ishii T, Nakamura T. Dose effects of cross-linking polyethylene for total knee arthroplasty on wear performance and mechanical properties. Journal of Biomedical Materials Research. Part B, Applied Biomaterials. 83: 615-22. PMID 17471519 DOI: 10.1002/Jbm.B.30835  0.065
2013 Henry BA, Clarke IJ. Animal Models for Manipulation of Thermogenesis Animal Models For the Study of Human Disease. 305-330. DOI: 10.1016/B978-0-12-415894-8.00014-2  0.064
1987 Slater A, Gude N, Clarke I. Haemodynamic changes and left ventricular performance during high-dose oestrogen administration to male trans-sexuals International Journal of Gynecology & Obstetrics. 25: 269-269. DOI: 10.1016/0020-7292(87)90279-7  0.063
2011 Castelo-Branco P, Zhang C, Lipman T, Fujitani M, Hansford L, Clarke I, Harley CB, Tressler R, Malkin D, Walker E, Kaplan DR, Dirks P, Tabori U. Neural tumor-initiating cells have distinct telomere maintenance and can be safely targeted for telomerase inhibition. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 111-21. PMID 21208905 DOI: 10.1158/1078-0432.Ccr-10-2075  0.061
2012 Labiran C, Clarke IN, Cutcliffe LT, Wang Y, Skilton RJ, Persson K, Bjartling C, Herrmann B, Christerson L, Marsh P. Genotyping markers used for multi locus VNTR analysis with ompA (MLVA-ompA) and multi sequence typing (MST) retain stability in Chlamydia trachomatis. Frontiers in Cellular and Infection Microbiology. 2: 68. PMID 22919659 DOI: 10.3389/fcimb.2012.00068  0.06
2008 Clarke IC, Manley MT. How do alternative bearing surfaces influence wear behavior? The Journal of the American Academy of Orthopaedic Surgeons. 16: S86-93. PMID 18612022  0.06
2013 Yau SW, Russo VC, Clarke IJ, Werther GA, Sabin MA. IGFBP-2 enhances insulin signalling and glucose uptake in human skeletal myotubes Obesity Research & Clinical Practice. 7: e44-e45. DOI: 10.1016/J.ORCP.2013.12.585  0.06
2008 Tsukamoto R, Williams PA, Shoji H, Hirakawa K, Yamamoto K, Tsukamoto M, Clarke IC. Wear in molded tibial inserts: knee simulator study of H1900 and GUR1050 polyethylenes. Journal of Biomedical Materials Research. Part B, Applied Biomaterials. 85: 314-9. PMID 17952886 DOI: 10.1002/jbm.b.30948  0.059
2009 Bivi N, Romanello M, Harrison R, Clarke I, Hoyle DC, Moro L, Ortolani F, Bonetti A, Quadrifoglio F, Tell G, Delneri D. Identification of secondary targets of N-containing bisphosphonates in mammalian cells via parallel competition analysis of the barcoded yeast deletion collection. Genome Biology. 10: R93. PMID 19744312 DOI: 10.1186/Gb-2009-10-9-R93  0.058
2015 Boffelli M, Doimo A, Marin E, Puppulin L, Zhu W, Sugano N, Clarke IC, Pezzotti G. Chemically driven tetragonal-to-monoclinic polymorphic transformation in retrieved ZTA femoral heads from dual mobility hip implants. Journal of the Mechanical Behavior of Biomedical Materials. 56: 195-204. PMID 26708254 DOI: 10.1016/J.Jmbbm.2015.11.032  0.058
2014 Sigar IM, Schripsema JH, Wang Y, Clarke IN, Cutcliffe LT, Seth-Smith HM, Thomson NR, Bjartling C, Unemo M, Persson K, Ramsey KH. Plasmid deficiency in urogenital isolates of Chlamydia trachomatis reduces infectivity and virulence in a mouse model. Pathogens and Disease. 70: 61-9. PMID 24022847 DOI: 10.1111/2049-632X.12086  0.057
2013 Pelt CE, Erickson J, Clarke I, Donaldson T, Layfield L, Peters CL. Histologic, serologic, and tribologic findings in failed metal-on-metal total hip arthroplasty: AAOS exhibit selection. The Journal of Bone and Joint Surgery. American Volume. 95: e163. PMID 24196475 DOI: 10.2106/JBJS.L.01446  0.057
2013 Gallo M, Ho J, Coutinho FJ, Vanner R, Lee L, Head R, Ling EK, Clarke ID, Dirks PB. A tumorigenic MLL-homeobox network in human glioblastoma stem cells. Cancer Research. 73: 417-27. PMID 23108137 DOI: 10.1158/0008-5472.CAN-12-1881  0.056
2014 Merry TL, Tran M, Stathopoulos M, Wiede F, Fam BC, Dodd GT, Clarke I, Watt MJ, Andrikopoulos S, Tiganis T. High-fat-fed obese glutathione peroxidase 1-deficient mice exhibit defective insulin secretion but protection from hepatic steatosis and liver damage. Antioxidants & Redox Signaling. 20: 2114-29. PMID 24252128 DOI: 10.1089/Ars.2013.5428  0.056
2011 Wang Y, Kahane S, Cutcliffe LT, Skilton RJ, Lambden PR, Clarke IN. Development of a transformation system for Chlamydia trachomatis: restoration of glycogen biosynthesis by acquisition of a plasmid shuttle vector. Plos Pathogens. 7: e1002258. PMID 21966270 DOI: 10.1371/journal.ppat.1002258  0.055
1998 Ohbatake M, Clarke I, Kimmel S, Kushida M, Merguerian P, Marcuzzi A, Peterson K, Honey C, Kim P. Is human testis an immune privileged tissue? Faseb Journal. 12: A1098.  0.055
2003 Pandha HS, Stockwin LH, Eaton J, Clarke IA, Dalgleish AG, Todryk SM, Blair GE. Coxsackie B and adenovirus receptor, integrin and major histocompatibility complex class I expression in human prostate cancer cell lines: implications for gene therapy strategies. Prostate Cancer and Prostatic Diseases. 6: 6-11. PMID 12664058 DOI: 10.1038/sj.pcan.4500611  0.055
2010 Lombardi AV, Berend KR, Seng BE, Clarke IC, Adams JB. Delta ceramic-on-alumina ceramic articulation in primary THA: prospective, randomized FDA-IDE study and retrieval analysis. Clinical Orthopaedics and Related Research. 468: 367-74. PMID 19885712 DOI: 10.1007/s11999-009-1143-9  0.054
2007 Tateiwa T, Clarke IC, Pezzotti G, Sedel L, Kumakura T, Shishido T, Yamamoto K. Surface micro-analyses of long-term worn retrieved "Osteal" alumina ceramic total hip replacement. Journal of Biomedical Materials Research. Part B, Applied Biomaterials. 83: 562-70. PMID 17455269 DOI: 10.1002/Jbm.B.30829  0.054
2014 Agnihotri S, Burrell K, Buczkowicz P, Remke M, Golbourn B, Chornenkyy Y, Gajadhar A, Fernandez NA, Clarke ID, Barszczyk MS, Pajovic S, Ternamian C, Head R, Sabha N, Sobol RW, et al. ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents. Cancer Discovery. 4: 1198-213. PMID 25100205 DOI: 10.1158/2159-8290.Cd-14-0157  0.054
2014 Halim T, Burgett M, Donaldson TK, Savisaar C, Bowsher J, Clarke IC. Profiling the third-body wear damage produced in CoCr surfaces by bone cement, CoCr, and Ti6Al4V debris: a 10-cycle metal-on-metal simulator test. Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine. 228: 703-13. PMID 25062741 DOI: 10.1177/0954411914538782  0.053
2007 Diamandis P, Wildenhain J, Clarke ID, Sacher AG, Graham J, Bellows DS, Ling EK, Ward RJ, Jamieson LG, Tyers M, Dirks PB. Chemical genetics reveals a complex functional ground state of neural stem cells. Nature Chemical Biology. 3: 268-73. PMID 17417631 DOI: 10.25011/Cim.V31I4.4797  0.053
2014 Ramsey KH, Schripsema JH, Smith BJ, Wang Y, Jham BC, O'Hagan KP, Thomson NR, Murthy AK, Skilton RJ, Chu P, Clarke IN. Plasmid CDS5 influences infectivity and virulence in a mouse model of Chlamydia trachomatis urogenital infection. Infection and Immunity. 82: 3341-9. PMID 24866804 DOI: 10.1128/IAI.01795-14  0.052
2004 Garner SA, Everson JS, Lambden PR, Fane BA, Clarke IN. Isolation, molecular characterisation and genome sequence of a bacteriophage (Chp3) from Chlamydophila pecorum. Virus Genes. 28: 207-14. PMID 14976421 DOI: 10.1023/B:Viru.0000016860.53035.F3  0.052
2001 Kawanabe K, Clarke IC, Tamura J, Akagi M, Good VD, Williams PA, Yamamoto K. Effects of A-P translation and rotation on the wear of UHMWPE in a total knee joint simulator. Journal of Biomedical Materials Research. 54: 400-6. PMID 11189047  0.052
2003 Deng Y, Batten CA, Liu BL, Lambden PR, Elschner M, Günther H, Otto P, Schnürch P, Eichhorn W, Herbst W, Clarke IN. Studies of epidemiology and seroprevalence of bovine noroviruses in Germany. Journal of Clinical Microbiology. 41: 2300-5. PMID 12791840  0.052
2014 Mack SC, Witt H, Piro RM, Gu L, Zuyderduyn S, Stütz AM, Wang X, Gallo M, Garzia L, Zayne K, Zhang X, Ramaswamy V, Jäger N, Jones DT, Sill M, ... ... Clarke I, et al. Epigenomic alterations define lethal CIMP-positive ependymomas of infancy. Nature. 506: 445-50. PMID 24553142 DOI: 10.1038/Nature13108  0.052
2014 Herod MR, Prince CA, Skilton RJ, Ward VK, Cooper JB, Clarke IN. Structure-based design and functional studies of novel noroviral 3C protease chimaeras offer insights into substrate specificity. The Biochemical Journal. 464: 461-72. PMID 25275273 DOI: 10.1042/BJ20140959  0.051
2010 Micevych P, Bondar G, Kuo J, Villaume K, Blanc M, Gouysse G, Walter T, Couderc C, Nejjari M, Vercherat C, Cordier-Bussat M, Roche C, Scoazec J, Anukulkitch C, Rao A, ... ... Clarke IJ, et al. ENETS Newsletter Winter 2009/2010 Neuroendocrinology. 91: 279-282. DOI: 10.1159/000280100  0.051
2014 Kwon W, Clarke I, Wodak R. Micro-Level Discursive Strategies for Constructing Shared Views around Strategic Issues in Team Meetings Journal of Management Studies. 51: 265-290. DOI: 10.1111/joms.12036  0.05
2009 Pollard SM, Yoshikawa K, Clarke ID, Danovi D, Stricker S, Russell R, Bayani J, Head R, Lee M, Bernstein M, Squire JA, Smith A, Dirks P. Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens. Cell Stem Cell. 4: 568-80. PMID 19497285 DOI: 10.1016/J.Stem.2009.03.014  0.049
2014 St. John JC, Srirattana K, Clarke IJ. Modifying the mitochondrial genome to enhance animal production Australasian Biotechnology. 24: 61.  0.049
2006 Balenci L, Clarke ID, Dirks PB, Assard N, Ducray F, Jouvet A, Belin MF, Honnorat J, Baudier J. IQGAP1 protein specifies amplifying cancer cells in glioblastoma multiforme. Cancer Research. 66: 9074-82. PMID 16982749 DOI: 10.1158/0008-5472.Can-06-0761  0.049
2011 Clarke IN. Evolution of Chlamydia trachomatis. Annals of the New York Academy of Sciences. 1230: E11-8. PMID 22239534 DOI: 10.1111/j.1749-6632.2011.06194.x  0.048
2009 Ward RJ, Lee L, Graham K, Satkunendran T, Yoshikawa K, Ling E, Harper L, Austin R, Nieuwenhuis E, Clarke ID, Hui CC, Dirks PB. Multipotent CD15+ cancer stem cells in patched-1-deficient mouse medulloblastoma. Cancer Research. 69: 4682-90. PMID 19487286 DOI: 10.1158/0008-5472.Can-09-0342  0.047
2002 Robinson S, Clarke IN, Vipond IB, Caul EO, Lambden PR. Epidemiology of human Sapporo-like caliciviruses in the South West of England: molecular characterisation of a genetically distinct isolate. Journal of Medical Virology. 67: 282-8. PMID 11992591 DOI: 10.1002/jmv.2219  0.045
2002 Chen Z, Lambden PR, Lau J, Caul EO, Clarke IN. Human group C rotavirus: completion of the genome sequence and gene coding assignments of a non-cultivatable rotavirus. Virus Research. 83: 179-87. PMID 11864750  0.045
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