Andrew D. Sharrocks - Publications

Affiliations: 
1995-1998 Biochemistry University of Manchester, Manchester, England, United Kingdom 

160 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Briggs P, Hunter AL, Yang SH, Sharrocks AD, Iqbal M. PEGS: An efficient tool for gene set enrichment within defined sets of genomic intervals. F1000research. 10: 570. PMID 34504687 DOI: 10.12688/f1000research.53926.1  1
2021 Nowicki-Osuch K, Zhuang L, Jammula S, Bleaney CW, Mahbubani KT, Devonshire G, Katz-Summercorn A, Eling N, Wilbrey-Clark A, Madissoon E, Gamble J, Di Pietro M, O'Donovan M, Meyer KB, Saeb-Parsy K, ... Sharrocks AD, et al. Molecular phenotyping reveals the identity of Barrett's esophagus and its malignant transition. Science (New York, N.Y.). 373: 760-767. PMID 34385390 DOI: 10.1126/science.abd1449  1
2021 Ji Z, Li Y, Liu SX, Sharrocks AD. Correction to article "The forkhead transcription factor FOXK2 premarks lineage-specific genes in human embryonic stem cells for activation during differentiation''. Nucleic Acids Research. PMID 33751103 DOI: 10.1093/nar/gkab221  1
2021 Ji Z, Li Y, Liu SX, Sharrocks AD. The forkhead transcription factor FOXK2 premarks lineage-specific genes in human embryonic stem cells for activation during differentiation. Nucleic Acids Research. PMID 33434264 DOI: 10.1093/nar/gkaa1281  1
2020 Xu W, Ye Y, Sharrocks AD, Zhang W, Chen X. Genome-wide Interrogation of Protein-DNA Interactions in Mammalian Cells Using ChIPmentation. Star Protocols. 1: 100187. PMID 33377081 DOI: 10.1016/j.xpro.2020.100187  1
2020 Connaughton DM, Dai R, Owen DJ, Marquez J, Mann N, Graham-Paquin AL, Nakayama M, Coyaud E, Laurent EMN, St-Germain JR, Blok LS, Vino A, Klämbt V, Deutsch K, Wu CW, ... ... Sharrocks AD, et al. Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations. American Journal of Human Genetics. PMID 32891193 DOI: 10.1016/J.Ajhg.2020.08.013  0.01
2020 Rogerson C, Ogden S, Britton E, Ang Y, Sharrocks AD. Repurposing of KLF5 activates a cell cycle signature during the progression from a precursor state to Oesophageal Adenocarcinoma. Elife. 9. PMID 32880368 DOI: 10.7554/Elife.57189  1
2020 Gerrard DT, Berry AA, Jennings RE, Birket MJ, Zarrineh P, Garstang MG, Withey SL, Short P, Jiménez-Gancedo S, Firbas PN, Donaldson I, Sharrocks AD, Hanley KP, Hurles ME, Gomez-Skarmeta JL, et al. Dynamic changes in the epigenomic landscape regulate human organogenesis and link to developmental disorders. Nature Communications. 11: 3920. PMID 32764605 DOI: 10.1038/S41467-020-17305-2  1
2020 Rowling EJ, Miskolczi Z, Nagaraju R, Wilcock DJ, Wang P, Telfer B, Li Y, Lasheras-Otero I, Redondo-Muñoz M, Sharrocks AD, Arozarena I, Wellbrock C. Cooperative behaviour and phenotype plasticity evolve during melanoma progression. Pigment Cell & Melanoma Research. PMID 32145051 DOI: 10.1111/Pcmr.12873  1
2019 Prise I, Sharrocks AD. ELK1 has a dual activating and repressive role in human embryonic stem cells. Wellcome Open Research. 4: 41. PMID 31346550 DOI: 10.12688/wellcomeopenres.15091.2  0.01
2019 Li Y, Aguilar-Martinez E, Sharrocks AD. Geno2proteo, a Tool for Batch Retrieval of DNA and Protein Sequences from Any Genomic or Protein Regions. Journal of Integrative Bioinformatics. PMID 31301672 DOI: 10.1515/Jib-2018-0090  1
2019 Yang SH, Andrabi M, Biss R, Murtuza Baker S, Iqbal M, Sharrocks AD. ZIC3 Controls the Transition from Naive to Primed Pluripotency. Cell Reports. 27: 3215-3227.e6. PMID 31189106 DOI: 10.1016/J.Celrep.2019.05.026  1
2019 Rogerson C, Britton E, Withey S, Hanley N, Ang Y, Sharrocks AD. Identification of a primitive intestinal transcription factor network shared between esophageal adenocarcinoma and its pre-cancerous precursor state. Genome Research. PMID 30962179 DOI: 10.1101/Gr.243345.118  1
2019 Nestal de Moraes G, Carneiro LDT, Maia RC, Lam EW, Sharrocks AD. FOXK2 Transcription Factor and Its Emerging Roles in Cancer. Cancers. 11. PMID 30897782 DOI: 10.3390/Cancers11030393  1
2019 Garcia E, Hayden A, Birts C, Britton E, Rogerson C, Bleaney CW, Cowie A, Pickard K, Mellone M, Choh C, Derouet M, Duriez P, Noble F, White MJ, Primrose JN, ... ... Sharrocks AD, et al. Author Correction: Authentication and characterisation of a new oesophageal adenocarcinoma cell line: MFD-1. Scientific Reports. 9: 318. PMID 30670740 DOI: 10.1038/S41598-018-37591-7  1
2019 Baross S, Williams S, Hentges K, Sharrocks A, Keavney B. BS54 Variation in cardiac long non-coding rnas in congenital heart disease Heart. 105. DOI: 10.1136/Heartjnl-2019-Bcs.215  0.01
2018 Baker SM, Rogerson C, Hayes A, Sharrocks AD, Rattray M. Classifying cells with Scasat, a single-cell ATAC-seq analysis tool. Nucleic Acids Research. PMID 30335168 DOI: 10.1093/Nar/Gky950  1
2018 Nestal de Moraes G, Ji Z, Fan LY, Yao S, Zona S, Sharrocks AD, Lam EW. SUMOylation modulates FOXK2-mediated paclitaxel sensitivity in breast cancer cells. Oncogenesis. 7: 29. PMID 29540677 DOI: 10.1038/s41389-018-0038-6  1
2017 Britton E, Rogerson C, Mehta S, Li Y, Li X, Fitzgerald RC, Ang YS, Sharrocks AD. Open chromatin profiling identifies AP1 as a transcriptional regulator in oesophageal adenocarcinoma. Plos Genetics. 13: e1006879. PMID 28859074 DOI: 10.1371/Journal.Pgen.1006879  1
2017 Nowicki-Osuch K, Li Y, Challinor M, Gerrard DT, Hanley NA, Sharrocks AD. EINCR1 is an EGF inducible lincRNA overexpressed in lung adenocarcinomas. Plos One. 12: e0181902. PMID 28732076 DOI: 10.1371/Journal.Pone.0181902  1
2016 Aguilar-Martinez E, Guo B, Sharrocks AD. RNF4 interacts with multiSUMOylated ETV4. Wellcome Open Research. 1: 3. PMID 28612051 DOI: 10.12688/wellcomeopenres.9935.2  1
2016 Aguilar-Martínez E, Sharrocks AD. The Use of Multimeric Protein Scaffolds for Identifying Multi-SUMO Binding Proteins. Methods in Molecular Biology (Clifton, N.J.). 1475: 195-204. PMID 27631807 DOI: 10.1007/978-1-4939-6358-4_14  0.01
2016 Garcia E, Hayden A, Birts C, Britton E, Cowie A, Pickard K, Mellone M, Choh C, Derouet M, Duriez P, Noble F, White MJ, Primrose JN, Strefford JC, Rose-Zerilli M, ... ... Sharrocks AD, et al. Authentication and characterisation of a new oesophageal adenocarcinoma cell line: MFD-1. Scientific Reports. 6: 32417. PMID 27600491 DOI: 10.1038/SREP32417).  1
2016 Wiseman EF, Chen X, Han N, Webber A, Ji Z, Sharrocks AD, Ang YS. Erratum to: 'Deregulation of the FOXM1 target gene network and its coregulatory partners in oesophageal adenocarcinoma'. Molecular Cancer. 15: 21. PMID 26936268 DOI: 10.1186/s12943-016-0506-6  1
2016 Veluscek G, Li Y, Yang SH, Sharrocks AD. Jun-Mediated Changes in Cell Adhesion Contribute to Mouse Embryonic Stem Cell Exit from Ground State Pluripotency. Stem Cells (Dayton, Ohio). PMID 26850660 DOI: 10.1002/Stem.2294  1
2015 Chen X, Ji Z, Webber A, Sharrocks AD. Genome-wide binding studies reveal DNA binding specificity mechanisms and functional interplay amongst Forkhead transcription factors. Nucleic Acids Research. PMID 26578569 DOI: 10.1093/Nar/Gkv1120  1
2015 Dibb M, Han N, Choudhury J, Hayes S, Valentine H, West C, Sharrocks AD, Ang YS. FOXM1 and polo-like kinase 1 are co-ordinately overexpressed in patients with gastric adenocarcinomas. Bmc Research Notes. 8: 676. PMID 26576650 DOI: 10.1186/S13104-015-1658-Y  1
2015 Darieva Z, Webber A, Warwood S, Sharrocks AD. Protein kinase C coordinates histone H3 phosphorylation and acetylation. Elife. 4. PMID 26468616 DOI: 10.7554/Elife.09886  1
2015 Ramkumar P, Lee CM, Moradian A, Sweredoski MJ, Hess S, Sharrocks AD, Haines DS, Reddy EP. JNK associated leucine zipper protein functions as a docking platform for Polo like kinase 1 and regulation of the associating transcription factor Forkhead box protein K1. The Journal of Biological Chemistry. PMID 26468278 DOI: 10.1074/Jbc.M115.664649  1
2015 de Moraes GN, Khongkow P, Gong C, Yao S, Gomes AR, Ji Z, Kandola N, Delbue D, Man EP, Khoo US, Sharrocks AD, Lam EW. Forkhead box K2 modulates epirubicin and paclitaxel sensitivity through FOXO3a in breast cancer. Oncogenesis. 4: e167. PMID 26344694 DOI: 10.1038/oncsis.2015.26  1
2015 Aguilar-Martinez E, Chen X, Webber A, Mould AP, Seifert A, Hay RT, Sharrocks AD. Screen for multi-SUMO-binding proteins reveals a multi-SIM-binding mechanism for recruitment of the transcriptional regulator ZMYM2 to chromatin. Proceedings of the National Academy of Sciences of the United States of America. 112: E4854-63. PMID 26283374 DOI: 10.1073/Pnas.1509716112  1
2015 Wiseman EF, Chen X, Han N, Webber A, Ji Z, Sharrocks AD, Ang YS. Deregulation of the FOXM1 target gene network and its coregulatory partners in oesophageal adenocarcinoma. Molecular Cancer. 14: 69. PMID 25889361 DOI: 10.1186/S12943-015-0339-8  1
2015 Aguilar-Martinez E, Morrisroe C, Sharrocks AD. The ubiquitin ligase UBE3A dampens ERK pathway signalling in HPV E6 transformed HeLa cells. Plos One. 10: e0119366. PMID 25815718 DOI: 10.1371/Journal.Pone.0119366  1
2015 Ji Z, Sharrocks AD. Changing partners: transcription factors form different complexes on and off chromatin. Molecular Systems Biology. 11: 782. PMID 25609651 DOI: 10.15252/Msb.20145936  1
2015 Darieva Z, Webber A, Warwood S, Sharrocks AD. Author response: Protein kinase C coordinates histone H3 phosphorylation and acetylation Elife. DOI: 10.7554/Elife.09886.020  1
2014 Yang SH, Kalkan T, Morissroe C, Marks H, Stunnenberg H, Smith A, Sharrocks AD. Otx2 and Oct4 drive early enhancer activation during embryonic stem cell transition from naive pluripotency. Cell Reports. 7: 1968-81. PMID 24931607 DOI: 10.1016/J.Celrep.2014.05.037  1
2014 Ji Z, Mohammed H, Webber A, Ridsdale J, Han N, Carroll JS, Sharrocks AD. The forkhead transcription factor FOXK2 acts as a chromatin targeting factor for the BAP1-containing histone deubiquitinase complex. Nucleic Acids Research. 42: 6232-42. PMID 24748658 DOI: 10.1093/Nar/Gku274  1
2014 Teoh PL, Sharrocks AD. WDR5, ASH2L, and RBBP5 control the efficiency of FOS transcript processing. Cellular & Molecular Biology Letters. 19: 215-32. PMID 24715476 DOI: 10.2478/S11658-014-0190-8  1
2014 Baymaz HI, Fournier A, Laget S, Ji Z, Jansen PW, Smits AH, Ferry L, Mensinga A, Poser I, Sharrocks A, Defossez PA, Vermeulen M. MBD5 and MBD6 interact with the human PR-DUB complex through their methyl-CpG-binding domain. Proteomics. 14: 2179-89. PMID 24634419 DOI: 10.1002/pmic.201400013  1
2014 Ji Z, Donaldson IJ, Liu J, Hayes A, Zeef LAH, Sharrocks AD. The forkhead transcription factor FOXK2 promotes AP-1-mediated transcriptional regulation [Molecular and Cellular Biology, 32, 2, (2012) 385-398] Molecular and Cellular Biology. 34: 1892. DOI: 10.1128/MCB.00410-14  1
2013 O'Donnell A, Yang SH, Sharrocks AD. PARP1 orchestrates variant histone exchange in signal-mediated transcriptional activation. Embo Reports. 14: 1084-91. PMID 24145797 DOI: 10.1038/Embor.2013.164  1
2013 Mancini Lombardi I, Palani S, Meitinger F, Darieva Z, Hofmann A, Sharrocks AD, Pereira G. Lre1 directly inhibits the NDR/Lats kinase Cbk1 at the cell division site in a phosphorylation-dependent manner. Current Biology : Cb. 23: 1736-45. PMID 23954433 DOI: 10.1016/J.Cub.2013.07.032  1
2013 Yang SH, Sharrocks AD. Ubc9 acetylation: a new route for achieving specificity in substrate SUMOylation. The Embo Journal. 32: 773-4. PMID 23395903 DOI: 10.1038/Emboj.2013.21  1
2013 Yang SH, Sharrocks AD, Whitmarsh AJ. MAP kinase signalling cascades and transcriptional regulation. Gene. 513: 1-13. PMID 23123731 DOI: 10.1016/J.Gene.2012.10.033  1
2013 Chen X, Müller GA, Quaas M, Fischer M, Han N, Stutchbury B, Sharrocks AD, Engeland K. The forkhead transcription factor FOXM1 controls cell cycle-dependent gene expression through an atypical chromatin binding mechanism. Molecular and Cellular Biology. 33: 227-36. PMID 23109430 DOI: 10.1128/Mcb.00881-12  1
2012 Odrowaz Z, Sharrocks AD. The ETS transcription factors ELK1 and GABPA regulate different gene networks to control MCF10A breast epithelial cell migration. Plos One. 7: e49892. PMID 23284628 DOI: 10.1371/Journal.Pone.0049892  1
2012 Yang SH, Kalkan T, Morrisroe C, Smith A, Sharrocks AD. A genome-wide RNAi screen reveals MAP kinase phosphatases as key ERK pathway regulators during embryonic stem cell differentiation. Plos Genetics. 8: e1003112. PMID 23271975 DOI: 10.1371/Journal.Pgen.1003112  1
2012 Dibb M, Han N, Choudhury J, Hayes S, Valentine H, West C, Ang YS, Sharrocks AD. The FOXM1-PLK1 axis is commonly upregulated in oesophageal adenocarcinoma. British Journal of Cancer. 107: 1766-75. PMID 23037713 DOI: 10.1038/Bjc.2012.424  1
2012 Darieva Z, Han N, Warwood S, Doris KS, Morgan BA, Sharrocks AD. Protein kinase C regulates late cell cycle-dependent gene expression. Molecular and Cellular Biology. 32: 4651-61. PMID 22966207 DOI: 10.1128/Mcb.06000-11  1
2012 Odrowaz Z, Sharrocks AD. ELK1 uses different DNA binding modes to regulate functionally distinct classes of target genes. Plos Genetics. 8: e1002694. PMID 22589737 DOI: 10.1371/Journal.Pgen.1002694  1
2012 Pritchett J, Harvey E, Athwal V, Berry A, Rowe C, Oakley F, Moles A, Mann DA, Bobola N, Sharrocks AD, Thomson BJ, Zaitoun AM, Irving WL, Guha IN, Hanley NA, et al. Osteopontin is a novel downstream target of SOX9 with diagnostic implications for progression of liver fibrosis in humans. Hepatology (Baltimore, Md.). 56: 1108-16. PMID 22488688 DOI: 10.1002/Hep.25758  1
2012 O'Donnell A, Odrowaz Z, Sharrocks AD. Immediate-early gene activation by the MAPK pathways: what do and don't we know? Biochemical Society Transactions. 40: 58-66. PMID 22260666 DOI: 10.1042/Bst20110636  1
2012 Ji Z, Donaldson IJ, Liu J, Hayes A, Zeef LA, Sharrocks AD. The forkhead transcription factor FOXK2 promotes AP-1-mediated transcriptional regulation. Molecular and Cellular Biology. 32: 385-98. PMID 22083952 DOI: 10.1128/Mcb.05504-11  1
2011 Keld R, Guo B, Downey P, Cummins R, Gulmann C, Ang YS, Sharrocks AD. PEA3/ETV4-related transcription factors coupled with active ERK signalling are associated with poor prognosis in gastric adenocarcinoma. British Journal of Cancer. 105: 124-30. PMID 21673681 DOI: 10.1038/Bjc.2011.187  1
2011 Guo B, Panagiotaki N, Warwood S, Sharrocks AD. Dynamic modification of the ETS transcription factor PEA3 by sumoylation and p300-mediated acetylation. Nucleic Acids Research. 39: 6403-13. PMID 21543453 DOI: 10.1093/Nar/Gkr267  1
2011 Demir O, Aysit N, Onder Z, Turkel N, Ozturk G, Sharrocks AD, Kurnaz IA. ETS-domain transcription factor Elk-1 mediates neuronal survival: SMN as a potential target. Biochimica Et Biophysica Acta. 1812: 652-62. PMID 21362474 DOI: 10.1016/J.Bbadis.2011.02.012  1
2011 Purtill FS, Whitehall SK, Williams ES, McInerny CJ, Sharrocks AD, Morgan BA. A homeodomain transcription factor regulates the DNA replication checkpoint in yeast. Cell Cycle (Georgetown, Tex.). 10: 664-70. PMID 21304269 DOI: 10.4161/Cc.10.4.14824  1
2010 Keld R, Guo B, Downey P, Gulmann C, Ang YS, Sharrocks AD. The ERK MAP kinase-PEA3/ETV4-MMP-1 axis is operative in oesophageal adenocarcinoma. Molecular Cancer. 9: 313. PMID 21143918 DOI: 10.1186/1476-4598-9-313  1
2010 Yang SH, Sharrocks AD. MAP Kinase: SUMO pathway interactions. Methods in Molecular Biology (Clifton, N.J.). 661: 343-67. PMID 20811994 DOI: 10.1007/978-1-60761-795-2_21  1
2010 Marais A, Ji Z, Child ES, Krause E, Mann DJ, Sharrocks AD. Cell cycle-dependent regulation of the forkhead transcription factor FOXK2 by CDK·cyclin complexes. The Journal of Biological Chemistry. 285: 35728-39. PMID 20810654 DOI: 10.1074/Jbc.M110.154005  1
2010 Yan D, Davis FJ, Sharrocks AD, Im HJ. Emerging roles of SUMO modification in arthritis. Gene. 466: 1-15. PMID 20627123 DOI: 10.1016/J.Gene.2010.07.003  1
2010 Darieva Z, Clancy A, Bulmer R, Williams E, Pic-Taylor A, Morgan BA, Sharrocks AD. A competitive transcription factor binding mechanism determines the timing of late cell cycle-dependent gene expression. Molecular Cell. 38: 29-40. PMID 20385087 DOI: 10.1016/J.Molcel.2010.02.030  1
2010 White RJ, Sharrocks AD. Coordinated control of the gene expression machinery. Trends in Genetics : Tig. 26: 214-20. PMID 20381190 DOI: 10.1016/J.Tig.2010.02.004  1
2010 Witty J, Aguilar-Martinez E, Sharrocks AD. SENP1 participates in the dynamic regulation of Elk-1 SUMOylation. The Biochemical Journal. 428: 247-54. PMID 20337593 DOI: 10.1042/Bj20091948  1
2010 Yang SH, Sharrocks AD. The SUMO E3 ligase activity of Pc2 is coordinated through a SUMO interaction motif. Molecular and Cellular Biology. 30: 2193-205. PMID 20176810 DOI: 10.1128/Mcb.01510-09  1
2010 Kasza A, Wyrzykowska P, Horwacik I, Tymoszuk P, Mizgalska D, Palmer K, Rokita H, Sharrocks AD, Jura J. Transcription factors Elk-1 and SRF are engaged in IL1-dependent regulation of ZC3H12A expression. Bmc Molecular Biology. 11: 14. PMID 20137095 DOI: 10.1186/1471-2199-11-14  1
2010 Merrill JC, Melhuish TA, Kagey MH, Yang SH, Sharrocks AD, Wotton D. A role for non-covalent SUMO interaction motifs in Pc2/CBX4 E3 activity. Plos One. 5: e8794. PMID 20098713 DOI: 10.1371/Journal.Pone.0008794  1
2009 Im HJ, Sharrocks AD, Lin X, Yan D, Kim J, van Wijnen AJ, Hipskind RA. Basic fibroblast growth factor induces matrix metalloproteinase-13 via ERK MAP kinase-altered phosphorylation and sumoylation of Elk-1 in human adult articular chondrocytes. Open Access Rheumatology : Research and Reviews. 1: 151-161. PMID 27789988 DOI: 10.2147/Oarrr.S7527  1
2009 Boros J, O'Donnell A, Donaldson IJ, Kasza A, Zeef L, Sharrocks AD. Overlapping promoter targeting by Elk-1 and other divergent ETS-domain transcription factor family members. Nucleic Acids Research. 37: 7368-80. PMID 19789270 DOI: 10.1093/Nar/Gkp804  1
2009 Boros J, Donaldson IJ, O'Donnell A, Odrowaz ZA, Zeef L, Lupien M, Meyer CA, Liu XS, Brown M, Sharrocks AD. Elucidation of the ELK1 target gene network reveals a role in the coordinate regulation of core components of the gene regulation machinery. Genome Research. 19: 1963-73. PMID 19687146 DOI: 10.1101/Gr.093047.109  1
2009 Guo B, Sharrocks AD. Extracellular signal-regulated kinase mitogen-activated protein kinase signaling initiates a dynamic interplay between sumoylation and ubiquitination to regulate the activity of the transcriptional activator PEA3. Molecular and Cellular Biology. 29: 3204-18. PMID 19307308 DOI: 10.1128/Mcb.01128-08  1
2009 Im HJ, Sharrocks AD, Lin X, Yan D, Kim J, Van Wijnen AJ, Hipskind RA. Basic fibroblast growth factor induces matrix metalloproteinase-13 via eRK MAP kinase-altered phosphorylation and sumoylation of Elk-1 in human adult articular chondrocytes Open Access Rheumatology: Research and Reviews. 1: 151-161.  1
2008 O'Donnell A, Yang SH, Sharrocks AD. MAP kinase-mediated c-fos regulation relies on a histone acetylation relay switch. Molecular Cell. 29: 780-5. PMID 18374651 DOI: 10.1016/J.Molcel.2008.01.019  1
2007 Guo B, Yang SH, Witty J, Sharrocks AD. Signalling pathways and the regulation of SUMO modification. Biochemical Society Transactions. 35: 1414-8. PMID 18031234 DOI: 10.1042/Bst0351414  1
2007 Alberstein M, Amit M, Vaknin K, O'Donnell A, Farhy C, Lerenthal Y, Shomron N, Shaham O, Sharrocks AD, Ashery-Padan R, Ast G. Regulation of transcription of the RNA splicing factor hSlu7 by Elk-1 and Sp1 affects alternative splicing. Rna (New York, N.Y.). 13: 1988-99. PMID 17804646 DOI: 10.1261/Rna.492907  1
2007 Freddie CT, Ji Z, Marais A, Sharrocks AD. Functional interactions between the Forkhead transcription factor FOXK1 and the MADS-box protein SRF. Nucleic Acids Research. 35: 5203-12. PMID 17670796 DOI: 10.1093/Nar/Gkm528  1
2007 Thompson PD, Webb M, Beckett W, Hinsley T, Jowitt T, Sharrocks AD, Tassabehji M. GTF2IRD1 regulates transcription by binding an evolutionarily conserved DNA motif 'GUCE'. Febs Letters. 581: 1233-42. PMID 17346708 DOI: 10.1016/J.Febslet.2007.02.040  1
2007 Zhang L, Yang SH, Sharrocks AD. Rev7/MAD2B links c-Jun N-terminal protein kinase pathway signaling to activation of the transcription factor Elk-1. Molecular and Cellular Biology. 27: 2861-9. PMID 17296730 DOI: 10.1128/Mcb.02276-06  1
2007 Sharrocks A. Meeting report: Escaping from the shadow of ubiquitin Biochemist. 29: 53.  1
2006 Darieva Z, Bulmer R, Pic-Taylor A, Doris KS, Geymonat M, Sedgwick SG, Morgan BA, Sharrocks AD. Polo kinase controls cell-cycle-dependent transcription by targeting a coactivator protein. Nature. 444: 494-8. PMID 17122856 DOI: 10.1038/Nature05339  1
2006 Yang SH, Galanis A, Witty J, Sharrocks AD. An extended consensus motif enhances the specificity of substrate modification by SUMO. The Embo Journal. 25: 5083-93. PMID 17036045 DOI: 10.1038/Sj.Emboj.7601383  1
2006 Elsby LM, O'Donnell AJ, Green LM, Sharrocks AD, Roberts SG. Assembly of transcription factor IIB at a promoter in vivo requires contact with RNA polymerase II. Embo Reports. 7: 898-903. PMID 16878124 DOI: 10.1038/Sj.Embor.7400767  1
2006 Sharrocks AD. Cell cycle: sustained ERK signalling represses the inhibitors. Current Biology : Cb. 16: R540-2. PMID 16860730 DOI: 10.1016/J.Cub.2006.06.038  1
2006 Guo B, Sallis RE, Greenall A, Petit MM, Jansen E, Young L, Van de Ven WJ, Sharrocks AD. The LIM domain protein LPP is a coactivator for the ETS domain transcription factor PEA3. Molecular and Cellular Biology. 26: 4529-38. PMID 16738319 DOI: 10.1128/Mcb.01667-05  1
2006 Yang SH, Sharrocks AD. PIASxalpha differentially regulates the amplitudes of transcriptional responses following activation of the ERK and p38 MAPK pathways. Molecular Cell. 22: 477-87. PMID 16713578 DOI: 10.1016/J.Molcel.2006.03.037  1
2006 Yang SH, Sharrocks AD. Convergence of the SUMO and MAPK pathways on the ETS-domain transcription factor Elk-1. Biochemical Society Symposium. 121-9. PMID 16626293 DOI: 10.1042/Bss0730121  1
2006 Sharrocks AD. PIAS proteins and transcriptional regulation--more than just SUMO E3 ligases? Genes & Development. 20: 754-8. PMID 16600908 DOI: 10.1101/Gad.1421006  1
2006 Yang SH, Sharrocks AD. Interplay of the SUMO and MAP kinase pathways. Ernst Schering Research Foundation Workshop. 193-209. PMID 16568956  1
2005 Yang SH, Sharrocks AD. PIASx acts as an Elk-1 coactivator by facilitating derepression. The Embo Journal. 24: 2161-71. PMID 15920481 DOI: 10.1038/Sj.Emboj.7600690  1
2005 Kasza A, O'Donnell A, Gascoigne K, Zeef LA, Hayes A, Sharrocks AD. The ETS domain transcription factor Elk-1 regulates the expression of its partner protein, SRF. The Journal of Biological Chemistry. 280: 1149-55. PMID 15531578 DOI: 10.1074/Jbc.M411161200  1
2005 Kasza A, O'Donnell A, Zeef L, Gascoigne K, Hayes A, Sharrocks AD. RhoA and MAPK pathways converge to regulate SRF gene expression Ukrain'Skyi Biokhimichnyi Zhurnal. 77: 183.  1
2004 Vickers ER, Kasza A, Kurnaz IA, Seifert A, Zeef LA, O'donnell A, Hayes A, Sharrocks AD. Ternary complex factor-serum response factor complex-regulated gene activity is required for cellular proliferation and inhibition of apoptotic cell death. Molecular and Cellular Biology. 24: 10340-51. PMID 15542842 DOI: 10.1128/Mcb.24.23.10340-10351.2004  1
2004 Pic-Taylor A, Darieva Z, Morgan BA, Sharrocks AD. Regulation of cell cycle-specific gene expression through cyclin-dependent kinase-mediated phosphorylation of the forkhead transcription factor Fkh2p. Molecular and Cellular Biology. 24: 10036-46. PMID 15509804 DOI: 10.1128/Mcb.24.22.10036-10046.2004  1
2004 Barsyte-Lovejoy D, Galanis A, Clancy A, Sharrocks AD. ERK5 is targeted to myocyte enhancer factor 2A (MEF2A) through a MAPK docking motif. The Biochemical Journal. 381: 693-9. PMID 15132737 DOI: 10.1042/Bj20031940  1
2004 Yang SH, Sharrocks AD. SUMO promotes HDAC-mediated transcriptional repression. Molecular Cell. 13: 611-7. PMID 14992729 DOI: 10.1016/S1097-2765(04)00060-7  1
2003 Yang SH, Sharrocks AD, Whitmarsh AJ. Transcriptional regulation by the MAP kinase signaling cascades. Gene. 320: 3-21. PMID 14597384 DOI: 10.1016/S0378-1119(03)00816-3  1
2003 Darieva Z, Pic-Taylor A, Boros J, Spanos A, Geymonat M, Reece RJ, Sedgwick SG, Sharrocks AD, Morgan BA. Cell cycle-regulated transcription through the FHA domain of Fkh2p and the coactivator Ndd1p. Current Biology : Cb. 13: 1740-5. PMID 14521842 DOI: 10.1016/J.Cub.2003.08.053  1
2003 Yang SH, Jaffray E, Senthinathan B, Hay RT, Sharrocks AD. SUMO and transcriptional repression: dynamic interactions between the MAP kinase and SUMO pathways. Cell Cycle (Georgetown, Tex.). 2: 528-30. PMID 14504467 DOI: 10.4161/Cc.2.6.597  1
2003 Stinson J, Inoue T, Yates P, Clancy A, Norton JD, Sharrocks AD. Regulation of TCF ETS-domain transcription factors by helix-loop-helix motifs. Nucleic Acids Research. 31: 4717-28. PMID 12907712 DOI: 10.1093/Nar/Gkg689  1
2003 Yang SH, Jaffray E, Hay RT, Sharrocks AD. Dynamic interplay of the SUMO and ERK pathways in regulating Elk-1 transcriptional activity. Molecular Cell. 12: 63-74. PMID 12887893 DOI: 10.1016/S1097-2765(03)00265-X  1
2003 Boros J, Lim FL, Darieva Z, Pic-Taylor A, Harman R, Morgan BA, Sharrocks AD. Molecular determinants of the cell-cycle regulated Mcm1p-Fkh2p transcription factor complex. Nucleic Acids Research. 31: 2279-88. PMID 12711672 DOI: 10.1093/Nar/Gkg347  1
2003 Li QJ, Yang SH, Maeda Y, Sladek FM, Sharrocks AD, Martins-Green M. MAP kinase phosphorylation-dependent activation of Elk-1 leads to activation of the co-activator p300. The Embo Journal. 22: 281-91. PMID 12514134 DOI: 10.1093/Emboj/Cdg028  1
2003 Lim FL, Hayes A, West AG, Pic-Taylor A, Darieva Z, Morgan BA, Oliver SG, Sharrocks AD. Mcm1p-induced DNA bending regulates the formation of ternary transcription factor complexes. Molecular and Cellular Biology. 23: 450-61. PMID 12509445 DOI: 10.1128/Mcb.23.2.450-461.2003  1
2002 Yang SH, Bumpass DC, Perkins ND, Sharrocks AD. The ETS domain transcription factor Elk-1 contains a novel class of repression domain. Molecular and Cellular Biology. 22: 5036-46. PMID 12077333 DOI: 10.1128/Mcb.22.14.5036-5046.2002  1
2002 Hayes A, Zhang N, Wu J, Butler PR, Hauser NC, Hoheisel JD, Lim FL, Sharrocks AD, Oliver SG. Hybridization array technology coupled with chemostat culture: Tools to interrogate gene expression in Saccharomyces cerevisiae. Methods (San Diego, Calif.). 26: 281-90. PMID 12054884 DOI: 10.1016/S1046-2023(02)00032-4  1
2002 Vickers ER, Sharrocks AD. The use of inducible engrailed fusion proteins to study the cellular functions of eukaryotic transcription factors. Methods (San Diego, Calif.). 26: 270-80. PMID 12054883 DOI: 10.1016/S1046-2023(02)00031-2  1
2002 Sharrocks AD. Modern approaches in studying gene expression. Methods (San Diego, Calif.). 26: 215-6. PMID 12054876 DOI: 10.1016/S1046-2023(02)00024-5  1
2002 Sharrocks AD. Complexities in ETS-domain transcription factor function and regulation: lessons from the TCF (ternary complex factor) subfamily. The Colworth Medal Lecture. Biochemical Society Transactions. 30: 1-9. PMID 12023815 DOI: 10.1042/0300-5127:0300001  1
2002 Hagan I, Sharrocks AD. Understanding cancer: from the gene to the organism. Conference on genes and cancer. Embo Reports. 3: 415-9. PMID 11991945 DOI: 10.1093/Embo-Reports/Kvf100  1
2002 Barsyte-Lovejoy D, Galanis A, Sharrocks AD. Specificity determinants in MAPK signaling to transcription factors. The Journal of Biological Chemistry. 277: 9896-903. PMID 11786537 DOI: 10.1074/Jbc.M108145200  1
2001 Sharrocks AD. The ETS-domain transcription factor family. Nature Reviews. Molecular Cell Biology. 2: 827-37. PMID 11715049 DOI: 10.1038/35099076  1
2001 Yang SH, Vickers E, Brehm A, Kouzarides T, Sharrocks AD. Temporal recruitment of the mSin3A-histone deacetylase corepressor complex to the ETS domain transcription factor Elk-1. Molecular and Cellular Biology. 21: 2802-14. PMID 11283259 DOI: 10.1128/Mcb.21.8.2802-2814.2001  1
2001 Greenall A, Willingham N, Cheung E, Boam DS, Sharrocks AD. DNA binding by the ETS-domain transcription factor PEA3 is regulated by intramolecular and intermolecular protein.protein interactions. The Journal of Biological Chemistry. 276: 16207-15. PMID 11278941 DOI: 10.1074/Jbc.M011582200  1
2001 Ohtani N, Zebedee Z, Huot TJ, Stinson JA, Sugimoto M, Ohashi Y, Sharrocks AD, Peters G, Hara E. Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence. Nature. 409: 1067-70. PMID 11234019 DOI: 10.1038/35059131  1
2001 Roberts EC, Deed RW, Inoue T, Norton JD, Sharrocks AD. Id helix-loop-helix proteins antagonize pax transcription factor activity by inhibiting DNA binding. Molecular and Cellular Biology. 21: 524-33. PMID 11134340 DOI: 10.1128/Mcb.21.2.524-533.2001  1
2001 Galanis A, Yang SH, Sharrocks AD. Selective targeting of MAPKs to the ETS domain transcription factor SAP-1. The Journal of Biological Chemistry. 276: 965-73. PMID 11029469 DOI: 10.1074/Jbc.M007697200  1
2001 Sharrocks AD. Complexities in ETS-Domain Transcription Factor Function and Regulation: Lessons from the TCF (Ternary Complex Factor) Subfamily Biochemical Society Transactions. 30: 1-9. DOI: 10.1042/Bst0300001  0.01
2000 Sharrocks AD. Introduction: the regulation of eukaryotic transcription factor function. Cellular and Molecular Life Sciences : Cmls. 57: 1147-8. PMID 11028907 DOI: 10.1007/Pl00000754  1
2000 Sharrocks AD, Yang SH, Galanis A. Docking domains and substrate-specificity determination for MAP kinases. Trends in Biochemical Sciences. 25: 448-53. PMID 10973059 DOI: 10.1016/S0968-0004(00)01627-3  1
2000 Pic A, Lim FL, Ross SJ, Veal EA, Johnson AL, Sultan MR, West AG, Johnston LH, Sharrocks AD, Morgan BA. The forkhead protein Fkh2 is a component of the yeast cell cycle transcription factor SFF. The Embo Journal. 19: 3750-61. PMID 10899128 DOI: 10.1093/Emboj/19.14.3750  1
2000 Huang K, Louis JM, Donaldson L, Lim FL, Sharrocks AD, Clore GM. Solution structure of the MEF2A-DNA complex: structural basis for the modulation of DNA bending and specificity by MADS-box transcription factors. The Embo Journal. 19: 2615-28. PMID 10835359 DOI: 10.1093/Emboj/19.11.2615  1
2000 Brown LA, Rodaway AR, Schilling TF, Jowett T, Ingham PW, Patient RK, Sharrocks AD. Insights into early vasculogenesis revealed by expression of the ETS-domain transcription factor Fli-1 in wild-type and mutant zebrafish embryos. Mechanisms of Development. 90: 237-52. PMID 10640707 DOI: 10.1016/S0925-4773(99)00256-7  1
2000 Dalgleish P, Sharrocks AD. The mechanism of complex formation between Fli-1 and SRF transcription factors. Nucleic Acids Research. 28: 560-9. PMID 10606656 DOI: 10.1093/Nar/28.2.560  1
1999 Brown LA, Yang SH, Hair A, Galanis A, Sharrocks AD. Molecular characterization of a zebrafish TCF ETS-domain transcription factor. Oncogene. 18: 7985-93. PMID 10637509 DOI: 10.1038/Sj.Onc.1203197  1
1999 Yang SH, Shore P, Willingham N, Lakey JH, Sharrocks AD. The mechanism of phosphorylation-inducible activation of the ETS-domain transcription factor Elk-1. The Embo Journal. 18: 5666-74. PMID 10523309 DOI: 10.1093/Emboj/18.20.5666  1
1999 Yang SH, Galanis A, Sharrocks AD. Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors. Molecular and Cellular Biology. 19: 4028-38. PMID 10330143 DOI: 10.1128/Mcb.19.6.4028  1
1999 West AG, Sharrocks AD. MADS-box transcription factors adopt alternative mechanisms for bending DNA. Journal of Molecular Biology. 286: 1311-23. PMID 10064699 DOI: 10.1006/Jmbi.1999.2576  1
1999 Yates PR, Atherton GT, Deed RW, Norton JD, Sharrocks AD. Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors. The Embo Journal. 18: 968-76. PMID 10022839 DOI: 10.1093/Emboj/18.4.968  1
1998 West AG, Causier BE, Davies B, Sharrocks AD. DNA binding and dimerisation determinants of Antirrhinum majus MADS-box transcription factors. Nucleic Acids Research. 26: 5277-87. PMID 9826749  1
1998 Brown LA, Amores A, Schilling TF, Jowett T, Baert JL, de Launoit Y, Sharrocks AD. Molecular characterization of the zebrafish PEA3 ETS-domain transcription factor. Oncogene. 17: 93-104. PMID 9671318 DOI: 10.1038/Sj.Onc.1201911  1
1998 Ling Y, West AG, Roberts EC, Lakey JH, Sharrocks AD. Interaction of transcription factors with serum response factor. Identification of the Elk-1 binding surface. The Journal of Biological Chemistry. 273: 10506-14. PMID 9553110 DOI: 10.1074/Jbc.273.17.10506  1
1998 Yang SH, Whitmarsh AJ, Davis RJ, Sharrocks AD. Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1. The Embo Journal. 17: 1740-9. PMID 9501095 DOI: 10.1093/Emboj/17.6.1740  1
1998 Yang SH, Yates PR, Whitmarsh AJ, Davis RJ, Sharrocks AD. The Elk-1 ETS-domain transcription factor contains a mitogen-activated protein kinase targeting motif. Molecular and Cellular Biology. 18: 710-20. PMID 9447967 DOI: 10.1128/Mcb.18.2.710  1
1997 Sharrocks AD, Brown AL, Ling Y, Yates PR. The ETS-domain transcription factor family. The International Journal of Biochemistry & Cell Biology. 29: 1371-87. PMID 9570133 DOI: 10.1016/S1357-2725(97)00086-1  1
1997 West AG, Sharrocks AD. The role of DNA-bending in MADS-box transcription factor function. Biochemical Society Transactions. 25: S639. PMID 9450067 DOI: 10.1042/Bst025S639  1
1997 Yang S, Yates PR, Whitmarsh AJ, Davis RJ, Sharrocks AD. The regulation of TCF transcription factors by MAP kinase cascades. Biochemical Society Transactions. 25: 153S. PMID 9191197 DOI: 10.1042/Bst025153S  1
1997 Ling Y, Lakey JH, Roberts CE, Sharrocks AD. Molecular characterization of the B-box protein-protein interaction motif of the ETS-domain transcription factor Elk-1. The Embo Journal. 16: 2431-40. PMID 9171356 DOI: 10.1093/Emboj/16.9.2431  1
1997 West AG, Shore P, Sharrocks AD. DNA binding by MADS-box transcription factors: a molecular mechanism for differential DNA bending. Molecular and Cellular Biology. 17: 2876-87. PMID 9111360  1
1997 Whitmarsh AJ, Yang SH, Su MS, Sharrocks AD, Davis RJ. Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factors. Molecular and Cellular Biology. 17: 2360-71. PMID 9111305 DOI: 10.1128/Mcb.17.5.2360  1
1997 West AG, Sharrocks AD. 104 the role of DNA-bending in MADSbox transcription factor function Biochemical Society Transactions. 25: S640.  1
1996 Shore P, Whitmarsh AJ, Bhaskaran R, Davis RJ, Waltho JP, Sharrocks AD. Determinants of DNA-binding specificity of ETS-domain transcription factors. Molecular and Cellular Biology. 16: 3338-49. PMID 8668149 DOI: 10.1128/Mcb.16.7.3338  1
1995 Shore P, Sharrocks AD. The ETS-domain transcription factors Elk-1 and SAP-1 exhibit differential DNA binding specificities Nucleic Acids Research. 23: 4698-4706. PMID 8524663 DOI: 10.1093/Nar/23.22.4698  1
1995 Shore P, Bisset L, Lakey J, Waltho JP, Virden R, Sharrocks AD. Characterization of the Elk-1 ETS DNA-binding domain Journal of Biological Chemistry. 270: 5805-5811. PMID 7890710 DOI: 10.1074/Jbc.270.11.5805  1
1995 Shore P, Sharrocks AD. The MADS-box family of transcription factors European Journal of Biochemistry. 229: 1-13. PMID 7744019 DOI: 10.1111/J.1432-1033.1995.0001L.X  1
1995 Sharrocks AD, Shore P. DNA bending in the ternary nucleoprotein complex at the c-fos promoter Nucleic Acids Research. 23: 2442-2449. PMID 7630721 DOI: 10.1093/Nar/23.13.2442  1
1995 Whitmarsh AJ, Shore P, Sharrocks AD, Davis RJ. Integration of MAP kinase signal transduction pathways at the serum response element Science. 269: 403-407. PMID 7618106 DOI: 10.1126/Science.7618106  1
1995 Sharrocks AD. ERK2/p42 MAP kinase stimulates both autonomous and SRF-dependent DNA binding by Elk-1 Febs Letters. 368: 77-80. PMID 7615093 DOI: 10.1016/0014-5793(95)00604-8  1
1994 Shore P, Sharrocks AD. The transcription factors Elk-1 and serum response factor interact by direct protein-protein contacts mediated by a short region of Elk-1 Molecular and Cellular Biology. 14: 3283-3291. PMID 8164681 DOI: 10.1128/Mcb.14.5.3283  1
1994 Sharrocks AD. A T7 expression vector for producing N- and C-terminal fusion proteins with glutathione S-transferase Gene. 138: 105-108. PMID 8125285 DOI: 10.1016/0378-1119(94)90789-7  1
1993 Green J, Sharrocks AD, Green B, Geisow M, Guest JR. Properties of FNR proteins substituted at each of the five cysteine residues Molecular Microbiology. 8: 61-68. PMID 8497198  1
1993 Sharrocks AD, Gille H, Shaw PE. Identification of Amino Acids Essential for DNA Binding and Dimerization in p67SRF: Implications for a Novel DNA-Binding Motif Molecular and Cellular Biology. 13: 123-132. PMID 8417320  1
1993 Sharrocks AD, Von Hesler F, Shaw PE. The identification of elements determining the different DMA binding specificities of the MADS box proteins p67SRF and RSRFC4 Nucleic Acids Research. 21: 215-221. PMID 8095095 DOI: 10.1093/Nar/21.2.215  1
1992 Sharrocks AD, Shaw PE. Improved primer design for PCR-based, site-directed mutagenesis Nucleic Acids Research. 20: 1147. PMID 1549485  1
1992 Green J, Sharrocks AD, MacInnes JI, Guest JR. Purification of HlyX, a potential regulator of haemolysin synthesis, and properties of HlyX:FNR hybrids. Proceedings. Biological Sciences / the Royal Society. 248: 79-84. PMID 1355913 DOI: 10.1098/Rspb.1992.0045  1
1992 Gille H, Sharrocks AD, Shaw PE. Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter Nature. 358: 414-417. PMID 1322499 DOI: 10.1038/358414A0  1
1991 Sharrocks AD, Hornby DP. Transcriptional analysis of the restriction and modification genes of bacteriophage P1. Molecular Microbiology. 5: 685-94. PMID 2046552 DOI: 10.1111/J.1365-2958.1991.Tb00740.X  1
1991 Sharrocks AD, Hornby DP. S1 nuclease transcript mapping using sequenase-derived single-stranded probes. Biotechniques. 10: 426, 428. PMID 1867849  1
1991 Sharrocks AD, Green J, Guest JR. FNR activates and represses transcription in vitro Proceedings of the Royal Society B: Biological Sciences. 245: 219-226. PMID 1684045  1
1990 Sharrocks AD, Green J, Guest JR. In vivo and in vitro mutants of FNR the anaerobic transcriptional regulator of E.coli Febs Letters. 270: 119-122. PMID 2226775 DOI: 10.1016/0014-5793(90)81248-M  1
1987 Sharrocks A, Hornby DP. A rapid method for Bal31 deletion analysis. Nucleic Acids Research. 15: 8564. PMID 3671095  1
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