Robert A. Pearce - Publications

Affiliations: 
University of Wisconsin, Madison, Madison, WI 

71 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Perouansky M, MacIver MB, Pearce RA. Wake Up, Neurons! Astrocytes Calling. Anesthesiology. 130: 361-363. PMID 30707121 DOI: 10.1097/ALN.0000000000002589  0.88
2015 Engin E, Zarnowska ED, Benke D, Tsvetkov E, Sigal M, Keist R, Bolshakov VY, Pearce RA, Rudolph U. Tonic Inhibitory Control of Dentate Gyrus Granule Cells by α5-Containing GABAA Receptors Reduces Memory Interference. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 13698-712. PMID 26446222 DOI: 10.1523/JNEUROSCI.1370-15.2015  1
2015 Rodgers FC, Zarnowska ED, Laha KT, Engin E, Zeller A, Keist R, Rudolph U, Pearce RA. Etomidate Impairs Long-Term Potentiation In Vitro by Targeting α5-Subunit Containing GABAA Receptors on Nonpyramidal Cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 9707-16. PMID 26134653 DOI: 10.1523/JNEUROSCI.0315-15.2015  1
2015 Zarnowska ED, Rodgers FC, Oh I, Rau V, Lor C, Laha KT, Jurd R, Rudolph U, Eger EI, Pearce RA. Etomidate blocks LTP and impairs learning but does not enhance tonic inhibition in mice carrying the N265M point mutation in the beta3 subunit of the GABA(A) receptor. Neuropharmacology. 93: 171-8. PMID 25680234 DOI: 10.1016/j.neuropharm.2015.01.011  1
2014 Gemperline E, Laha K, Scarlett CO, Pearce RA, Li L. Measurement of NMDA Receptor Antagonist, CPP, in Mouse Plasma and Brain Tissue Following Systematic Administration Using Ion-Pair LCMS/MS. Analytical Methods : Advancing Methods and Applications. 6: 6389-6396. PMID 25663848 DOI: 10.1039/c4ay01168f  1
2014 Balakrishnan S, Pearce RA. Spatiotemporal characteristics and pharmacological modulation of multiple gamma oscillations in the CA1 region of the hippocampus. Frontiers in Neural Circuits. 8: 150. PMID 25628540 DOI: 10.3389/fncir.2014.00150  1
2014 Burkat PM, Lor C, Perouansky M, Pearce RA. Enhancement of α5-containing γ-aminobutyric acid type A receptors by the nonimmobilizer 1,2-dichlorohexafluorocyclobutane (F6) is abolished by the β3(N265M) mutation. Anesthesia and Analgesia. 119: 1277-84. PMID 25211390 DOI: 10.1213/ANE.0000000000000423  0.52
2014 Goldschen-Ohm MP, Haroldson A, Jones MV, Pearce RA. A nonequilibrium binary elements-based kinetic model for benzodiazepine regulation of GABAA receptors. The Journal of General Physiology. 144: 27-39. PMID 24981228 DOI: 10.1085/jgp.201411183  1
2014 Balakrishnan S, Pearce RA. Midazolam and atropine alter theta oscillations in the hippocampal CA1 region by modulating both the somatic and distal dendritic dipoles. Hippocampus. 24: 1212-31. PMID 24862458 DOI: 10.1002/hipo.22307  1
2012 Jee JP, Parlato MC, Perkins MG, Mecozzi S, Pearce RA. Exceptionally stable fluorous emulsions for the intravenous delivery of volatile general anesthetics. Anesthesiology. 116: 580-5. PMID 22354241 DOI: 10.1097/ALN.0b013e3182475d4d  1
2012 Dai S, Perouansky M, Pearce RA. Isoflurane enhances both fast and slow synaptic inhibition in the hippocampus at amnestic concentrations. Anesthesiology. 116: 816-23. PMID 22343472 DOI: 10.1097/ALN.0b013e31824be0e3  1
2012 Pearce RA, Duscher P, Van Dyke K, Lee M, Andrei AC, Perouansky M. Isoflurane impairs odour discrimination learning in rats: differential effects on short- and long-term memory. British Journal of Anaesthesia. 108: 630-7. PMID 22258200 DOI: 10.1093/bja/aer451  1
2011 Johnson RA, Simmons KT, Fast JP, Schroeder CA, Pearce RA, Albrecht RM, Mecozzi S. Histamine release associated with intravenous delivery of a fluorocarbon-based sevoflurane emulsion in canines. Journal of Pharmaceutical Sciences. 100: 2685-92. PMID 21246564 DOI: 10.1002/jps.22488  1
2011 Perouansky M, Pearce RA. How we recall (or don't): the hippocampal memory machine and anesthetic amnesia. Canadian Journal of Anaesthesia = Journal Canadien D'AnesthéSie. 58: 157-66. PMID 21170624 DOI: 10.1007/s12630-010-9417-y  1
2011 Capogna M, Pearce RA. GABA A,slow: causes and consequences. Trends in Neurosciences. 34: 101-12. PMID 21145601 DOI: 10.1016/j.tins.2010.10.005  1
2010 Perouansky M, Rau V, Ford T, Oh SI, Perkins M, Eger EI, Pearce RA. Slowing of the hippocampal θ rhythm correlates with anesthetic-induced amnesia. Anesthesiology. 113: 1299-309. PMID 21042201 DOI: 10.1097/ALN.0b013e3181f90ccc  1
2010 Hall MA, Xi J, Lor C, Dai S, Pearce R, Dailey WP, Eckenhoff RG. m-Azipropofol (AziPm) a photoactive analogue of the intravenous general anesthetic propofol. Journal of Medicinal Chemistry. 53: 5667-75. PMID 20597506 DOI: 10.1021/jm1004072  1
2010 Boileau AJ, Pearce RA, Czajkowski C. The short splice variant of the gamma 2 subunit acts as an external modulator of GABA(A) receptor function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 4895-903. PMID 20371809 DOI: 10.1523/JNEUROSCI.5039-09.2010  1
2010 Blake AJ, Rodgers FC, Bassuener A, Hippensteel JA, Pearce TM, Pearce TR, Zarnowska ED, Pearce RA, Williams JC. A microfluidic brain slice perfusion chamber for multisite recording using penetrating electrodes. Journal of Neuroscience Methods. 189: 5-13. PMID 20219536 DOI: 10.1016/j.jneumeth.2010.02.017  1
2010 Ferrarelli F, Massimini M, Sarasso S, Casali A, Riedner BA, Angelini G, Tononi G, Pearce RA. Breakdown in cortical effective connectivity during midazolam-induced loss of consciousness. Proceedings of the National Academy of Sciences of the United States of America. 107: 2681-6. PMID 20133802 DOI: 10.1073/pnas.0913008107  1
2009 Hentschke H, Benkwitz C, Banks MI, Perkins MG, Homanics GE, Pearce RA. Altered GABAA,slow inhibition and network oscillations in mice lacking the GABAA receptor beta3 subunit. Journal of Neurophysiology. 102: 3643-55. PMID 19846622 DOI: 10.1152/jn.00651.2009  1
2009 Dai S, Perouansky M, Pearce RA. Amnestic concentrations of etomidate modulate GABAA,slow synaptic inhibition in hippocampus. Anesthesiology. 111: 766-73. PMID 19741493 DOI: 10.1097/ALN.0b013e3181b4392d  1
2009 Pearce RA. All together now. Anesthesiology. 110: 964-6. PMID 19352156 DOI: 10.1097/ALN.0b013e31819db946  1
2009 Butts CA, Xi J, Brannigan G, Saad AA, Venkatachalan SP, Pearce RA, Klein ML, Eckenhoff RG, Dmochowski IJ. Identification of a fluorescent general anesthetic, 1-aminoanthracene. Proceedings of the National Academy of Sciences of the United States of America. 106: 6501-6. PMID 19346473 DOI: 10.1073/pnas.0810590106  1
2009 Zarnowska ED, Keist R, Rudolph U, Pearce RA. GABAA receptor alpha5 subunits contribute to GABAA,slow synaptic inhibition in mouse hippocampus. Journal of Neurophysiology. 101: 1179-91. PMID 19073796 DOI: 10.1152/jn.91203.2008  1
2008 Fast JP, Perkins MG, Pearce RA, Mecozzi S. Fluoropolymer-based emulsions for the intravenous delivery of sevoflurane. Anesthesiology. 109: 651-6. PMID 18813044 DOI: 10.1097/ALN.0b013e31818630ff  1
2007 Hentschke H, Perkins MG, Pearce RA, Banks MI. Muscarinic blockade weakens interaction of gamma with theta rhythms in mouse hippocampus. The European Journal of Neuroscience. 26: 1642-56. PMID 17880398 DOI: 10.1111/j.1460-9568.2007.05779.x  1
2007 Perouansky M, Hentschke H, Perkins M, Pearce RA. Amnesic concentrations of the nonimmobilizer 1,2-dichlorohexafluorocyclobutane (F6, 2N) and isoflurane alter hippocampal theta oscillations in vivo. Anesthesiology. 106: 1168-76. PMID 17525592 DOI: 10.1097/01.anes.0000267600.09764.af  1
2007 Johnson MA, Weick JP, Pearce RA, Zhang SC. Functional neural development from human embryonic stem cells: accelerated synaptic activity via astrocyte coculture. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 3069-77. PMID 17376968 DOI: 10.1523/JNEUROSCI.4562-06.2007  1
2007 Benkwitz C, Liao M, Laster MJ, Sonner JM, Eger EI, Pearce RA. Determination of the EC50 amnesic concentration of etomidate and its diffusion profile in brain tissue: implications for in vitro studies. Anesthesiology. 106: 114-23. PMID 17197853 DOI: 10.1097/00000542-200701000-00020  1
2006 Hardie JB, Pearce RA. Active and passive membrane properties and intrinsic kinetics shape synaptic inhibition in hippocampal CA1 pyramidal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 8559-69. PMID 16914682 DOI: 10.1523/JNEUROSCI.0547-06.2006  1
2006 Borghese CM, Werner DF, Topf N, Baron NV, Henderson LA, Boehm SL, Blednov YA, Saad A, Dai S, Pearce RA, Harris RA, Homanics GE, Harrison NL. An isoflurane- and alcohol-insensitive mutant GABA(A) receptor alpha(1) subunit with near-normal apparent affinity for GABA: characterization in heterologous systems and production of knockin mice. The Journal of Pharmacology and Experimental Therapeutics. 319: 208-18. PMID 16807363 DOI: 10.1124/jpet.106.104406  1
2005 Boileau AJ, Pearce RA, Czajkowski C. Tandem subunits effectively constrain GABAA receptor stoichiometry and recapitulate receptor kinetics but are insensitive to GABAA receptor-associated protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 11219-30. PMID 16339017 DOI: 10.1523/JNEUROSCI.3751-05.2005  1
2005 Zarnowska ED, Pearce RA, Saad AA, Perouansky M. The gamma-subunit governs the susceptibility of recombinant gamma-aminobutyric acid type A receptors to block by the nonimmobilizer 1,2-dichlorohexafluorocyclobutane (F6, 2N). Anesthesia and Analgesia. 101: 401-6, table of cont. PMID 16037152 DOI: 10.1213/01.ANE.0000155264.67729.E4  1
2005 Perouansky M, Banks MI, Pearce RA. The differential effects of the nonimmobilizer 1,2-dichlorohexafluorocyclobutane (F6, 2N) and isoflurane on extrasynaptic gamma-aminobutyric acid A receptors. Anesthesia and Analgesia. 100: 1667-73. PMID 15920193 DOI: 10.1213/01.ANE.0000150942.68328.66  1
2005 Yan Y, Yang D, Zarnowska ED, Du Z, Werbel B, Valliere C, Pearce RA, Thomson JA, Zhang SC. Directed differentiation of dopaminergic neuronal subtypes from human embryonic stem cells. Stem Cells (Dayton, Ohio). 23: 781-90. PMID 15917474 DOI: 10.1634/stemcells.2004-0365  1
2005 Li XJ, Du ZW, Zarnowska ED, Pankratz M, Hansen LO, Pearce RA, Zhang SC. Specification of motoneurons from human embryonic stem cells. Nature Biotechnology. 23: 215-21. PMID 15685164 DOI: 10.1038/nbt1063  1
2005 Perouansky M, Pearce RA. Non-immobilizers put to the test: F6 and the GABAA receptor International Congress Series. 1283: 73-78. DOI: 10.1016/j.ics.2005.06.040  1
2004 Benkwitz C, Banks MI, Pearce RA. Influence of GABAA receptor gamma2 splice variants on receptor kinetics and isoflurane modulation. Anesthesiology. 101: 924-36. PMID 15448526 DOI: 10.1097/00000542-200410000-00018  1
2004 Gredell JA, Turnquist PA, Maciver MB, Pearce RA. Determination of diffusion and partition coefficients of propofol in rat brain tissue: implications for studies of drug action in vitro. British Journal of Anaesthesia. 93: 810-7. PMID 15377586 DOI: 10.1093/bja/aeh272  1
2004 Mody I, Pearce RA. Diversity of inhibitory neurotransmission through GABA(A) receptors. Trends in Neurosciences. 27: 569-75. PMID 15331240 DOI: 10.1016/j.tins.2004.07.002  1
2004 Perouansky M, Pearce RA. Effects on synaptic inhibition in the hippocampus do not underlie the amnestic and convulsive properties of the nonimmobilizer 1,2-dichlorohexafluorocyclobutane. Anesthesiology. 101: 66-74. PMID 15220773 DOI: 10.1097/00000542-200407000-00012  1
2004 Perouansky M, Hemmings HC, Pearce RA. Anesthetic effects on glutamatergic neurotransmission: lessons learned from a large synapse. Anesthesiology. 100: 470-2. PMID 15108957 DOI: 10.1097/00000542-200403000-00003  1
2003 Chesney MA, Perouansky M, Pearce RA. Differential uptake of volatile agents into brain tissue in vitro. Measurement and application of a diffusion model to determine concentration profiles in brain slices. Anesthesiology. 99: 122-30. PMID 12826851 DOI: 10.1097/00000542-200307000-00021  1
2003 Boileau AJ, Li T, Benkwitz C, Czajkowski C, Pearce RA. Effects of gamma2S subunit incorporation on GABAA receptor macroscopic kinetics. Neuropharmacology. 44: 1003-12. PMID 12763093 DOI: 10.1016/S0028-3908(03)00114-X  1
2003 Eger EI, Xing Y, Pearce R, Shafer S, Laster MJ, Zhang Y, Fanselow MS, Sonner JM. Isoflurane antagonizes the capacity of flurothyl or 1,2-dichlorohexafluorocyclobutane to impair fear conditioning to context and tone. Anesthesia and Analgesia. 96: 1010-8, table of con. PMID 12651651  1
2002 Banks MI, Hardie JB, Pearce RA. Development of GABA(A) receptor-mediated inhibitory postsynaptic currents in hippocampus. Journal of Neurophysiology. 88: 3097-107. PMID 12466433 DOI: 10.1152/jn.00026.2002  1
2000 Perouansky M, Pearce RA. Is anesthesia caused by potentiation of synaptic or intrinsic inhibition? Recent insights into the mechanisms of volatile anesthetics. Journal of Basic and Clinical Physiology and Pharmacology. 11: 83-107. PMID 11037765  1
2000 White JA, Banks MI, Pearce RA, Kopell NJ. Networks of interneurons with fast and slow gamma-aminobutyric acid type A (GABAA) kinetics provide substrate for mixed gamma-theta rhythm. Proceedings of the National Academy of Sciences of the United States of America. 97: 8128-33. PMID 10869419 DOI: 10.1073/pnas.100124097  1
2000 Li X, Czajkowski C, Pearce RA. Rapid and direct modulation of GABAA receptors by halothane. Anesthesiology. 92: 1366-75. PMID 10781283  1
2000 Banks MI, White JA, Pearce RA. Interactions between distinct GABA(A) circuits in hippocampus. Neuron. 25: 449-57. PMID 10719898  1
2000 Banks MI, Pearce RA. Kinetic differences between synaptic and extrasynaptic GABA(A) receptors in CA1 pyramidal cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 937-48. PMID 10648698  1
2000 Li X, Pearce RA. Effects of halothane on GABA(A) receptor kinetics: evidence for slowed agonist unbinding. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 899-907. PMID 10648694  1
1999 Pearce RA. Barbiturates and the brain. Anesthesiology. 91: 1190-2. PMID 10551566 DOI: 10.1097/00000542-199911000-00007  1
1999 Banks MI, Pearce RA. Dual actions of volatile anesthetics on GABA(A) IPSCs: dissociation of blocking and prolonging effects. Anesthesiology. 90: 120-34. PMID 9915321  1
1998 Hagan CE, Pearce RA, Trudell JR, MacIver MB. Concentration measures of volatile anesthetics in the aqueous phase using calcium sensitive electrodes. Journal of Neuroscience Methods. 81: 177-84. PMID 9696323 DOI: 10.1016/S0165-0270(98)00029-6  1
1998 Banks MI, Li TB, Pearce RA. The synaptic basis of GABAA,slow. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 1305-17. PMID 9454840  1
1997 Kapur A, Pearce RA, Lytton WW, Haberly LB. GABAA-mediated IPSCs in piriform cortex have fast and slow components with different properties and locations on pyramidal cells. Journal of Neurophysiology. 78: 2531-45. PMID 9356403  1
1996 Pearce RA. Volatile anaesthetic enhancement of paired-pulse depression investigated in the rat hippocampus in vitro. The Journal of Physiology. 492: 823-40. PMID 8734993  1
1996 McCall MA, Gregg RG, Behringer RR, Brenner M, Delaney CL, Galbreath EJ, Zhang CL, Pearce RA, Chiu SY, Messing A. Targeted deletion in astrocyte intermediate filament (Gfap) alters neuronal physiology. Proceedings of the National Academy of Sciences of the United States of America. 93: 6361-6. PMID 8692820 DOI: 10.1073/pnas.93.13.6361  1
1995 Pearce RA, Grunder SD, Faucher LD. Different mechanisms for use-dependent depression of two GABAA-mediated IPSCs in rat hippocampus. The Journal of Physiology. 484: 425-35. PMID 7602535  1
1993 Pearce RA. Physiological evidence for two distinct GABAA responses in rat hippocampus. Neuron. 10: 189-200. PMID 8382497 DOI: 10.1016/0896-6273(93)90310-N  1
1993 Banks MI, Pearce RA, Smith PH. Hyperpolarization-activated cation current (Ih) in neurons of the medial nucleus of the trapezoid body: voltage-clamp analysis and enhancement by norepinephrine and cAMP suggest a modulatory mechanism in the auditory brain stem. Journal of Neurophysiology. 70: 1420-32. PMID 7506755  1
1993 Friesen WO, Pearce RA. Mechanisms of intersegmental coordination in leech locomotion Seminars in Neuroscience. 5: 41-47. DOI: 10.1016/S1044-5765(05)80023-5  1
1989 Pearce RA, Stringer JL, Lothman EW. Effect of volatile anesthetics on synaptic transmission in the rat hippocampus. Anesthesiology. 71: 591-8. PMID 2802217  1
1989 Pearce RA, Stornetta RL, Guyenet PG. Retrotrapezoid nucleus in the rat. Neuroscience Letters. 101: 138-42. PMID 2771161 DOI: 10.1016/0304-3940(89)90520-X  1
1988 Pearce RA, Friesen WO. A model for intersegmental coordination in the leech nerve cord. Biological Cybernetics. 58: 301-11. PMID 3382701 DOI: 10.1007/BF00363939  1
1987 Nusbaum MP, Friesen WO, Kristan WB, Pearce RA. Neural mechanisms generating the leech swimming rhythm: swim-initiator neurons excite the network of swim oscillator neurons. Journal of Comparative Physiology. a, Sensory, Neural, and Behavioral Physiology. 161: 355-66. PMID 3668878 DOI: 10.1007/BF00603961  1
1985 Pearce RA, Friesen WO. Intersegmental coordination of the leech swimming rhythm. II. Comparison of long and short chains of ganglia. Journal of Neurophysiology. 54: 1460-72. PMID 4087043  1
1985 Pearce RA, Friesen WO. Intersegmental coordination of the leech swimming rhythm. I. Roles of cycle period gradient and coupling strength. Journal of Neurophysiology. 54: 1444-59. PMID 4087042  1
1984 Pearce RA, Friesen WO. Intersegmental coordination of leech swimming: comparison of in situ and isolated nerve cord activity with body wall movement. Brain Research. 299: 363-6. PMID 6733455 DOI: 10.1016/0006-8993(84)90720-0  1
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