ype Elgersma - Publications

Affiliations: 
Erasmus Medical Center Rotterdam, Rotterdam, Netherlands 
Area:
learning and memory

99 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Castricum J, Birkenhager TK, Kushner SA, Elgersma Y, Tulen JHM. Cortical Inhibition and Plasticity in Major Depressive Disorder. Frontiers in Psychiatry. 13: 777422. PMID 35153873 DOI: 10.3389/fpsyt.2022.777422  0.565
2021 Homberg JR, Adan RAH, Alenina N, Asiminas A, Bader M, Beckers T, Begg DP, Blokland A, Burger ME, van Dijk G, Eisel ULM, Elgersma Y, Englitz B, Fernandez-Ruiz A, Fitzsimons CP, et al. The continued need for animals to advance brain research. Neuron. 109: 2374-2379. PMID 34352213 DOI: 10.1016/j.neuron.2021.07.015  0.501
2021 Borrie SC, Plasschaert E, Callaerts-Vegh Z, Yoshimura A, D'Hooge R, Elgersma Y, Kushner SA, Legius E, Brems H. MEK inhibition ameliorates social behavior phenotypes in a Spred1 knockout mouse model for RASopathy disorders. Molecular Autism. 12: 53. PMID 34311771 DOI: 10.1186/s13229-021-00458-2  0.56
2021 Proietti Onori M, Koene LMC, Schäfer CB, Nellist M, de Brito van Velze M, Gao Z, Elgersma Y, van Woerden GM. RHEB/mTOR hyperactivity causes cortical malformations and epileptic seizures through increased axonal connectivity. Plos Biology. 19: e3001279. PMID 34038402 DOI: 10.1371/journal.pbio.3001279  0.781
2021 van Woerden GM, Bos M, de Konink C, Distel B, Trezza RA, Shur NE, Barañano K, Mahida S, Chassevent A, Schreiber A, Erwin AL, Gripp KW, Rehman F, Brulleman S, Mc Cormack R, ... ... Elgersma Y, et al. TAOK1 is associated with neurodevelopmental disorder and essential for neuronal maturation and cortical development. Human Mutation. PMID 33565190 DOI: 10.1002/humu.24176  0.678
2020 Genzel L, Adan R, Berns A, van den Beucken JJJP, Blokland A, Boddeke EHWGM, Bogers WM, Bontrop R, Bulthuis R, Bousema T, Clevers H, Coenen TCJJ, van Dam AM, Deen PMT, van Dijk KW, ... ... Elgersma Y, et al. How the COVID-19 pandemic highlights the necessity of animal research. Current Biology : Cb. 30: 4328. PMID 33142090 DOI: 10.1016/j.cub.2020.10.033  0.495
2020 Castricum J, Tulen JHM, Taal W, Ottenhoff MJ, Kushner SA, Elgersma Y. Motor cortical excitability and plasticity in patients with neurofibromatosis type 1. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology. 131: 2673-2681. PMID 32977190 DOI: 10.1016/J.Clinph.2020.08.016  0.608
2020 Genzel L, Adan R, Berns A, van den Beucken J, Blokland A, Boddeke EHWGM, Bogers WM, Bontrop R, Bulthuis R, Bousema T, Clevers H, Coenen TCJJ, Dam AV, Deen PMT, van Dijk KW, ... ... Elgersma Y, et al. How the COVID-19 pandemic highlights the necessity of animal research. Current Biology : Cb. 30: R1014-R1018. PMID 32961149 DOI: 10.1016/J.Cub.2020.08.030  0.552
2020 Sonzogni M, Zhai P, Mientjes EJ, van Woerden GM, Elgersma Y. Assessing the requirements of prenatal UBE3A expression for rescue of behavioral phenotypes in a mouse model for Angelman syndrome. Molecular Autism. 11: 70. PMID 32948244 DOI: 10.1186/s13229-020-00376-9  0.657
2020 Zampeta IF, Sonzogni M, Niggl E, Lendemeijer B, Smeenk H, de Vrij FMS, Kushner SA, Distel B, Elgersma Y. Conserved UBE3A subcellular distribution between human and mice is facilitated by non-homologous isoforms. Human Molecular Genetics. PMID 32879944 DOI: 10.1093/Hmg/Ddaa194  0.587
2020 Ottenhoff MJ, Krab LC, Elgersma Y. Considerations for clinical therapeutic development of statins for neurodevelopmental disorders. Eneuro. PMID 32071072 DOI: 10.1523/ENEURO.0392-19.2020  0.746
2019 Tonazzini I, Van Woerden GM, Masciullo C, Mientjes EJ, Elgersma Y, Cecchini M. The role of ubiquitin ligase E3A in polarized contact guidance and rescue strategies in UBE3A-deficient hippocampal neurons. Molecular Autism. 10: 41. PMID 31798818 DOI: 10.1186/s13229-019-0293-1  0.69
2019 Heimer G, van Woerden GM, Barel O, Marek-Yagel D, Kol N, Munting BJ, Borghei M, Atawneh OM, Nissenkorn A, Rechavi G, Anikster Y, Elgersma Y, Kushner SA, Ben Zeev B. Netrin-G2 dysfunction causes a Rett-like phenotype with areflexia. Human Mutation. PMID 31692205 DOI: 10.1002/Humu.23945  0.759
2019 Koene LMC, van Grondelle SE, Proietti Onori M, Wallaard I, Kooijman NHRM, van Oort A, Schreiber J, Elgersma Y. Effects of antiepileptic drugs in a new TSC/mTOR-dependent epilepsy mouse model. Annals of Clinical and Translational Neurology. 6: 1273-1291. PMID 31353861 DOI: 10.1002/acn3.50829  0.769
2019 Avagliano Trezza R, Sonzogni M, Bossuyt SNV, Zampeta FI, Punt AM, van den Berg M, Rotaru DC, Koene LMC, Munshi ST, Stedehouder J, Kros JM, Williams M, Heussler H, de Vrij FMS, Mientjes EJ, ... ... Elgersma Y, et al. Loss of nuclear UBE3A causes electrophysiological and behavioral deficits in mice and is associated with Angelman syndrome. Nature Neuroscience. PMID 31235931 DOI: 10.1038/S41593-019-0425-0  0.764
2019 Overwater IE, Rietman AB, Mous SE, Bindels-de Heus K, Rizopoulos D, Ten Hoopen LW, van der Vaart T, Jansen FE, Elgersma Y, Moll HA, de Wit MY. A randomized controlled trial with everolimus for IQ and autism in tuberous sclerosis complex. Neurology. PMID 31217257 DOI: 10.1212/WNL.0000000000007749  0.687
2019 Sonzogni M, Hakonen J, Bernabé Kleijn M, Silva-Santos S, Judson MC, Philpot BD, van Woerden GM, Elgersma Y. Delayed loss of UBE3A reduces the expression of Angelman syndrome-associated phenotypes. Molecular Autism. 10: 23. PMID 31143434 DOI: 10.1186/S13229-019-0277-1  0.68
2019 Kool MJ, Onori MP, Borgesius NZ, van de Bree JE, Elgersma-Hooisma M, Nio E, Bezstarosti K, Buitendijk GHS, Aghadavoud Jolfaei M, Demmers JAA, Elgersma Y, van Woerden GM. CAMK2-dependent signaling in neurons is essential for survival. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31064859 DOI: 10.1523/JNEUROSCI.1341-18.2019  0.657
2019 Castricum J, Tulen J, Ottenhoff M, Taal W, Kushner S, Elgersma Y. Cortical plasticity induced by intermittent Theta Burst Stimulation in NF1 patients and unaffected controls Brain Stimulation. 12: 409. DOI: 10.1016/J.Brs.2018.12.319  0.569
2018 Sonzogni M, Wallaard I, Santos SS, Kingma J, du Mee D, van Woerden GM, Elgersma Y. A behavioral test battery for mouse models of Angelman syndrome: a powerful tool for testing drugs and novel mutants. Molecular Autism. 9: 47. PMID 30220990 DOI: 10.1186/s13229-018-0231-7  0.657
2018 Onori MP, Koopal B, Everman DB, Worthington JD, Jones JR, Ploeg MA, Mientjes E, van Bon BW, Kleefstra T, Schulman H, Kushner SA, Küry S, Elgersma Y, van Woerden GM. The intellectual disability-associated CAMK2G p.Arg292Pro mutation acts as a pathogenic gain-of-function. Human Mutation. PMID 30184290 DOI: 10.1002/Humu.23647  0.755
2018 Rotaru DC, van Woerden GM, Wallaard I, Elgersma Y. Adult gene reinstatement restores the electrophysiological deficits of prefrontal cortex layer 5 neurons in a mouse model of Angelman syndrome. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 30082419 DOI: 10.1523/JNEUROSCI.0083-18.2018  0.657
2018 de Vrij FM, Bouwkamp CG, Gunhanlar N, Shpak G, Lendemeijer B, Baghdadi M, Gopalakrishna S, Ghazvini M, Li TM, Quadri M, Olgiati S, Breedveld GJ, Coesmans M, Mientjes E, de Wit T, ... ... Elgersma Y, et al. Candidate CSPG4 mutations and induced pluripotent stem cell modeling implicate oligodendrocyte progenitor cell dysfunction in familial schizophrenia. Molecular Psychiatry. PMID 29302076 DOI: 10.1038/S41380-017-0004-2  0.569
2017 Wang T, van Woerden GM, Elgersma Y, Borst JGG. Enhanced Transmission at the Calyx of Held Synapse in a Mouse Model for Angelman Syndrome. Frontiers in Cellular Neuroscience. 11: 418. PMID 29354033 DOI: 10.3389/fncel.2017.00418  0.657
2017 Bazzigaluppi P, Isenia SC, Haasdijk ED, Elgersma Y, De Zeeuw CI, van der Giessen RS, de Jeu MTG. Modulation of Murine Olivary Connexin 36 Gap Junctions by PKA and CaMKII. Frontiers in Cellular Neuroscience. 11: 397. PMID 29311830 DOI: 10.3389/fncel.2017.00397  0.359
2017 Küry S, van Woerden GM, Besnard T, Proietti Onori M, Latypova X, Towne MC, Cho MT, Prescott TE, Ploeg MA, Sanders S, Stessman HAF, Pujol A, Distel B, Robak LA, Bernstein JA, ... ... Elgersma Y, et al. De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability. American Journal of Human Genetics. 101: 768-788. PMID 29100089 DOI: 10.1016/J.Ajhg.2017.10.003  0.791
2017 Reijnders MRF, Kousi M, van Woerden GM, Klein M, Bralten J, Mancini GMS, van Essen T, Proietti-Onori M, Smeets EEJ, van Gastel M, Stegmann APA, Stevens SJC, Lelieveld SH, Gilissen C, Pfundt R, ... ... Elgersma Y, et al. Variation in a range of mTOR-related genes associates with intracranial volume and intellectual disability. Nature Communications. 8: 1052. PMID 29051493 DOI: 10.1038/S41467-017-00933-6  0.676
2017 Wallace ML, van Woerden GM, Elgersma Y, Smith SL, Philpot BD. UBE3A loss increases excitability and blunts orientation tuning in the visual cortex of Angelman syndrome model mice. Journal of Neurophysiology. jn.00618.2016. PMID 28468997 DOI: 10.1152/Jn.00618.2016  0.692
2017 Schreiber J, Grimbergen LA, Overwater I, Vaart TV, Stedehouder J, Schuhmacher AJ, Guerra C, Kushner SA, Jaarsma D, Elgersma Y. Mechanisms underlying cognitive deficits in a mouse model for Costello Syndrome are distinct from other RASopathy mouse models. Scientific Reports. 7: 1256. PMID 28455524 DOI: 10.1038/S41598-017-01218-0  0.626
2017 Borrie S, Plasschaert E, Elgersma Y, Kushner S, Legius E, Brems H. Social deficits in mouse models of Neurofibromatosis type 1 and Legius syndrome Frontiers in Neuroscience. 11. DOI: 10.3389/Conf.Fnins.2017.94.00027  0.57
2016 Kool MJ, van de Bree JE, Bodde HE, Elgersma Y, van Woerden GM. The molecular, temporal and region-specific requirements of the beta isoform of Calcium/Calmodulin-dependent protein kinase type 2 (CAMK2B) in mouse locomotion. Scientific Reports. 6: 26989. PMID 27244486 DOI: 10.1038/srep26989  0.657
2016 Gouty-Colomer LA, Hosseini B, Marcelo IM, Schreiber J, Slump DE, Yamaguchi S, Houweling AR, Jaarsma D, Elgersma Y, Kushner SA. Arc expression identifies the lateral amygdala fear memory trace. Molecular Psychiatry. PMID 27217149 DOI: 10.1038/Mp.2016.91  0.64
2016 Judson MC, Wallace ML, Sidorov MS, Burette AC, Gu B, van Woerden GM, King IF, Han JE, Zylka MJ, Elgersma Y, Weinberg RJ, Philpot BD. GABAergic Neuron-Specific Loss of Ube3a Causes Angelman Syndrome-Like EEG Abnormalities and Enhances Seizure Susceptibility. Neuron. PMID 27021170 DOI: 10.1016/j.neuron.2016.02.040  0.693
2016 Tonazzini I, Meucci S, Van Woerden GM, Elgersma Y, Cecchini M. Impaired Neurite Contact Guidance in Ubiquitin Ligase E3a (Ube3a)-Deficient Hippocampal Neurons on Nanostructured Substrates. Advanced Healthcare Materials. PMID 26845073 DOI: 10.1002/adhm.201500815  0.657
2015 van der Vaart T, Rietman AB, Plasschaert E, Legius E, Elgersma Y, Moll HA. Behavioral and cognitive outcomes for clinical trials in children with neurofibromatosis type 1. Neurology. PMID 26519538 DOI: 10.1212/WNL.0000000000002118  0.687
2015 Omrani A, van Woerden GM, Elgersma Y. Neurofibromin regulates HCN activity in Parvalbumin-positive interneurons. Molecular Psychiatry. 20: 1263. PMID 26487477 DOI: 10.1038/mp.2015.154  0.725
2015 Bruinsma CF, Schonewille M, Gao Z, Aronica EM, Judson MC, Philpot BD, Hoebeek FE, van Woerden GM, De Zeeuw CI, Elgersma Y. Dissociation of locomotor and cerebellar deficits in a murine Angelman syndrome model. The Journal of Clinical Investigation. 125: 4305-15. PMID 26485287 DOI: 10.1172/Jci83541  0.794
2015 Bruinsma CF, Savelberg SM, Kool MJ, Jolfaei MA, van Woerden GM, Baarends WM, Elgersma Y. An essential role for UBE2A/HR6A in learning and memory and mGLUR-dependent long-term depression. Human Molecular Genetics. PMID 26476408 DOI: 10.1093/Hmg/Ddv436  0.759
2015 Alves MM, Fuhler GM, Queiroz KC, Scholma J, Goorden S, Anink J, Arnold Spek C, Hoogeveen-Westerveld M, Bruno MJ, Nellist M, Elgersma Y, Aronica E, Peppelenbosch MP. PAK2 is an effector of TSC1/2 signaling independent of mTOR and a potential therapeutic target for Tuberous Sclerosis Complex. Scientific Reports. 5: 14534. PMID 26412398 DOI: 10.1038/srep14534  0.672
2015 Wang T, de Kok L, Willemsen R, Elgersma Y, Borst JG. In vivo synaptic transmission and morphology in mouse models of Tuberous sclerosis, Fragile X syndrome, Neurofibromatosis type 1, and Costello syndrome. Frontiers in Cellular Neuroscience. 9: 234. PMID 26190969 DOI: 10.3389/fncel.2015.00234  0.37
2015 van der Vaart T, Overwater IE, Oostenbrink R, Moll HA, Elgersma Y. Treatment of Cognitive Deficits in Genetic Disorders: A Systematic Review of Clinical Trials of Diet and Drug Treatments. Jama Neurology. 72: 1052-60. PMID 26168015 DOI: 10.1001/jamaneurol.2015.0443  0.687
2015 Omrani A, van der Vaart T, Mientjes E, van Woerden GM, Hojjati MR, Li KW, Gutmann DH, Levelt CN, Smit AB, Silva AJ, Kushner SA, Elgersma Y. HCN channels are a novel therapeutic target for cognitive dysfunction in Neurofibromatosis type 1. Molecular Psychiatry. PMID 25917366 DOI: 10.1038/Mp.2015.48  0.774
2015 Korf B, Ahmadian R, Allanson J, Aoki Y, Bakker A, Wright EB, Denger B, Elgersma Y, Gelb BD, Gripp KW, Kerr B, Kontaridis M, Lazaro C, Linardic C, Lozano R, et al. The third international meeting on genetic disorders in the RAS/MAPK pathway: Towards a therapeutic approach. American Journal of Medical Genetics. Part A. PMID 25900621 DOI: 10.1002/Ajmg.A.37089  0.484
2015 Silva-Santos S, van Woerden GM, Bruinsma CF, Mientjes E, Jolfaei MA, Distel B, Kushner SA, Elgersma Y. Ube3a reinstatement identifies distinct developmental windows in a murine Angelman syndrome model. The Journal of Clinical Investigation. 125: 2069-76. PMID 25866966 DOI: 10.1172/Jci80554  0.785
2015 Gouty-Colomer LA, Hosseini B, Marcelo IM, Schreiber J, Slump DE, Yamaguchi S, Houweling AR, Jaarsma D, Elgersma Y, Kushner SA. Arc expression identifies the lateral amygdala fear memory trace. Molecular Psychiatry. PMID 25802982 DOI: 10.1038/Mp.2015.18  0.682
2015 Goorden SM, Abs E, Bruinsma CF, Riemslagh FW, van Woerden GM, Elgersma Y. Intact neuronal function in Rheb1 mutant mice: implications for TORC1-based treatments. Human Molecular Genetics. 24: 3390-8. PMID 25759467 DOI: 10.1093/Hmg/Ddv087  0.754
2014 Arruda-Carvalho M, Restivo L, Guskjolen A, Epp JR, Elgersma Y, Josselyn SA, Frankland PW. Conditional deletion of α-CaMKII impairs integration of adult-generated granule cells into dentate gyrus circuits and hippocampus-dependent learning. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 11919-28. PMID 25186740 DOI: 10.1523/Jneurosci.0652-14.2014  0.712
2014 Achterberg KG, Buitendijk GH, Kool MJ, Goorden SM, Post L, Slump DE, Silva AJ, van Woerden GM, Kushner SA, Elgersma Y. Temporal and region-specific requirements of αCaMKII in spatial and contextual learning. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 11180-7. PMID 25143599 DOI: 10.1523/Jneurosci.0640-14.2014  0.789
2014 Gao Z, van Woerden GM, Elgersma Y, De Zeeuw CI, Hoebeek FE. Distinct roles of α- and βCaMKII in controlling long-term potentiation of GABAA-receptor mediated transmission in murine Purkinje cells. Frontiers in Cellular Neuroscience. 8: 16. PMID 24550776 DOI: 10.3389/fncel.2014.00016  0.691
2013 Groenewoud MJ, Goorden SM, Kassies J, Pellis-van Berkel W, Lamb RF, Elgersma Y, Zwartkruis FJ. Mammalian target of rapamycin complex I (mTORC1) activity in ras homologue enriched in brain (Rheb)-deficient mouse embryonic fibroblasts. Plos One. 8: e81649. PMID 24303063 DOI: 10.1371/journal.pone.0081649  0.672
2013 van der Vaart T, Plasschaert E, Rietman AB, Renard M, Oostenbrink R, Vogels A, de Wit MC, Descheemaeker MJ, Vergouwe Y, Catsman-Berrevoets CE, Legius E, Elgersma Y, Moll HA. Simvastatin for cognitive deficits and behavioural problems in patients with neurofibromatosis type 1 (NF1-SIMCODA): a randomised, placebo-controlled trial. The Lancet. Neurology. 12: 1076-83. PMID 24090588 DOI: 10.1016/S1474-4422(13)70227-8  0.687
2013 Galliano E, Potters JW, Elgersma Y, Wisden W, Kushner SA, De Zeeuw CI, Hoebeek FE. Synaptic transmission and plasticity at inputs to murine cerebellar Purkinje cells are largely dispensable for standard nonmotor tasks. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 12599-618. PMID 23904597 DOI: 10.1523/Jneurosci.1642-13.2013  0.598
2013 Abs E, Goorden SM, Schreiber J, Overwater IE, Hoogeveen-Westerveld M, Bruinsma CF, Aganović E, Borgesius NZ, Nellist M, Elgersma Y. TORC1-dependent epilepsy caused by acute biallelic Tsc1 deletion in adult mice. Annals of Neurology. 74: 569-79. PMID 23720219 DOI: 10.1002/Ana.23943  0.77
2013 Melser S, Chatelain EH, Lavie J, Mahfouf W, Jose C, Obre E, Goorden S, Priault M, Elgersma Y, Rezvani HR, Rossignol R, Bénard G. Rheb regulates mitophagy induced by mitochondrial energetic status. Cell Metabolism. 17: 719-30. PMID 23602449 DOI: 10.1016/J.Cmet.2013.03.014  0.672
2013 Acosta MT, Bearden CE, Castellanos XF, Cutting L, Elgersma Y, Gioia G, Gutmann DH, Lee YS, Legius E, Muenke M, North K, Parada LF, Ratner N, Hunter-Schaedle K, Silva AJ. Corrigendum to "The Learning Disabilities Network (LeaDNet): Using Neurofibromatosis Type 1 [NF1] as a Paradigm for Translational Research" American Journal of Medical Genetics, Part A. 161: 236. DOI: 10.1002/Ajmg.A.35667  0.502
2012 Castrén E, Elgersma Y, Maffei L, Hagerman R. Treatment of neurodevelopmental disorders in adulthood. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 14074-9. PMID 23055475 DOI: 10.1523/Jneurosci.3287-12.2012  0.3
2012 Acosta MT, Bearden CE, Castellanos FX, Castellanos XF, Cutting L, Elgersma Y, Gioia G, Gutmann DH, Lee YS, Legius E, Muenke M, North K, Parada LF, Ratner N, Hunter-Schaedle K, et al. The Learning Disabilities Network (LeaDNet): using neurofibromatosis type 1 (NF1) as a paradigm for translational research. American Journal of Medical Genetics. Part A. 158: 2225-32. PMID 22821737 DOI: 10.1002/Ajmg.A.35535  0.647
2012 Steinkellner T, Yang JW, Montgomery TR, Chen WQ, Winkler MT, Sucic S, Lubec G, Freissmuth M, Elgersma Y, Sitte HH, Kudlacek O. Ca(2+)/calmodulin-dependent protein kinase IIα (αCaMKII) controls the activity of the dopamine transporter: implications for Angelman syndrome. The Journal of Biological Chemistry. 287: 29627-35. PMID 22778257 DOI: 10.1074/Jbc.M112.367219  0.311
2012 van Beveren NJ, Krab LC, Swagemakers S, Buitendijk G, Buitendijk GH, Boot E, van der Spek P, Elgersma Y, van Amelsvoort TA. Functional gene-expression analysis shows involvement of schizophrenia-relevant pathways in patients with 22q11 deletion syndrome. Plos One. 7: e33473. PMID 22457764 DOI: 10.1371/journal.pone.0033473  0.758
2012 van Beveren NJ, Buitendijk GH, Swagemakers S, Krab LC, Röder C, de Haan L, van der Spek P, Elgersma Y. Marked reduction of AKT1 expression and deregulation of AKT1-associated pathways in peripheral blood mononuclear cells of schizophrenia patients. Plos One. 7: e32618. PMID 22393424 DOI: 10.1371/journal.pone.0032618  0.758
2012 Cho J, Bhatt R, Elgersma Y, Silva AJ. α-Calcium calmodulin kinase II modulates the temporal structure of hippocampal bursting patterns. Plos One. 7: e31649. PMID 22363696 DOI: 10.1371/Journal.Pone.0031649  0.725
2012 Beveren NJMv, Krab LC, Swagemakers S, Buitendijk GHS, Boot E, Spek Pvd, Elgersma Y, Amelsvoort TAMJv. Correction: Functional Gene-Expression Analysis Shows Involvement of Schizophrenia-Relevant Pathways in Patients with 22q11 Deletion Syndrome Plos One. 7. DOI: 10.1371/Annotation/D80F4E7D-5E96-41Da-9Dae-717B0D0D3C60  0.758
2011 Borgesius NZ, de Waard MC, van der Pluijm I, Omrani A, Zondag GC, van der Horst GT, Melton DW, Hoeijmakers JH, Jaarsma D, Elgersma Y. Accelerated age-related cognitive decline and neurodegeneration, caused by deficient DNA repair. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 12543-53. PMID 21880916 DOI: 10.1523/JNEUROSCI.1589-11.2011  0.588
2011 Borgesius NZ, van Woerden GM, Buitendijk GH, Keijzer N, Jaarsma D, Hoogenraad CC, Elgersma Y. βCaMKII plays a nonenzymatic role in hippocampal synaptic plasticity and learning by targeting αCaMKII to synapses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 10141-8. PMID 21752990 DOI: 10.1523/JNEUROSCI.5105-10.2011  0.657
2011 Goorden SM, Elgersma Y. Rheb: enrichment beyond the brain. Cell Cycle (Georgetown, Tex.). 10: 2412-3. PMID 21670600 DOI: 10.4161/cc.10.15.16385  0.672
2011 van der Vaart T, van Woerden GM, Elgersma Y, de Zeeuw CI, Schonewille M. Motor deficits in neurofibromatosis type 1 mice: the role of the cerebellum. Genes, Brain, and Behavior. 10: 404-9. PMID 21352477 DOI: 10.1111/J.1601-183X.2011.00685.X  0.792
2011 Goorden SM, Hoogeveen-Westerveld M, Cheng C, van Woerden GM, Mozaffari M, Post L, Duckers HJ, Nellist M, Elgersma Y. Rheb is essential for murine development. Molecular and Cellular Biology. 31: 1672-8. PMID 21321084 DOI: 10.1128/MCB.00985-10  0.782
2011 Krab LC, de Goede-Bolder A, Aarsen FK, Moll HA, De Zeeuw CI, Elgersma Y, van der Geest JN. Motor learning in children with neurofibromatosis type I. Cerebellum (London, England). 10: 14-21. PMID 20927664 DOI: 10.1007/s12311-010-0217-2  0.768
2010 Belmeguenai A, Hosy E, Bengtsson F, Pedroarena CM, Piochon C, Teuling E, He Q, Ohtsuki G, De Jeu MT, Elgersma Y, De Zeeuw CI, Jörntell H, Hansel C. Intrinsic plasticity complements long-term potentiation in parallel fiber input gain control in cerebellar Purkinje cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 13630-43. PMID 20943904 DOI: 10.1523/Jneurosci.3226-10.2010  0.323
2010 Schonewille M, Belmeguenai A, Koekkoek SK, Houtman SH, Boele HJ, van Beugen BJ, Gao Z, Badura A, Ohtsuki G, Amerika WE, Hosy E, Hoebeek FE, Elgersma Y, Hansel C, De Zeeuw CI. Purkinje cell-specific knockout of the protein phosphatase PP2B impairs potentiation and cerebellar motor learning. Neuron. 67: 618-28. PMID 20797538 DOI: 10.1016/J.Neuron.2010.07.009  0.367
2010 de Waard MC, van der Pluijm I, Zuiderveen Borgesius N, Comley LH, Haasdijk ED, Rijksen Y, Ridwan Y, Zondag G, Hoeijmakers JH, Elgersma Y, Gillingwater TH, Jaarsma D. Age-related motor neuron degeneration in DNA repair-deficient Ercc1 mice. Acta Neuropathologica. 120: 461-75. PMID 20602234 DOI: 10.1007/s00401-010-0715-9  0.757
2009 van Woerden GM, Hoebeek FE, Gao Z, Nagaraja RY, Hoogenraad CC, Kushner SA, Hansel C, De Zeeuw CI, Elgersma Y. betaCaMKII controls the direction of plasticity at parallel fiber-Purkinje cell synapses. Nature Neuroscience. 12: 823-5. PMID 19503086 DOI: 10.1038/Nn.2329  0.75
2009 Krab LC, Oostenbrink R, de Goede-Bolder A, Aarsen FK, Elgersma Y, Moll HA. Health-related quality of life in children with neurofibromatosis type 1: contribution of demographic factors, disease-related factors, and behavior. The Journal of Pediatrics. 154: 420-5, 425.e1. PMID 18950800 DOI: 10.1016/j.jpeds.2008.08.045  0.758
2008 Denayer E, Ahmed T, Brems H, Van Woerden G, Borgesius NZ, Callaerts-Vegh Z, Yoshimura A, Hartmann D, Elgersma Y, D'Hooge R, Legius E, Balschun D. Spred1 is required for synaptic plasticity and hippocampus-dependent learning. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 14443-9. PMID 19118178 DOI: 10.1523/Jneurosci.4698-08.2008  0.714
2008 Cui Y, Costa RM, Murphy GG, Elgersma Y, Zhu Y, Gutmann DH, Parada LF, Mody I, Silva AJ. Neurofibromin regulation of ERK signaling modulates GABA release and learning. Cell. 135: 549-60. PMID 18984165 DOI: 10.1016/J.Cell.2008.09.060  0.783
2008 Krab LC, Aarsen FK, de Goede-Bolder A, Catsman-Berrevoets CE, Arts WF, Moll HA, Elgersma Y. Impact of neurofibromatosis type 1 on school performance. Journal of Child Neurology. 23: 1002-10. PMID 18827266 DOI: 10.1177/0883073808316366  0.758
2008 Krab LC, Goorden SM, Elgersma Y. Oncogenes on my mind: ERK and MTOR signaling in cognitive diseases. Trends in Genetics : Tig. 24: 498-510. PMID 18774199 DOI: 10.1016/j.tig.2008.07.005  0.765
2008 Krab LC, de Goede-Bolder A, Aarsen FK, Pluijm SM, Bouman MJ, van der Geest JN, Lequin M, Catsman CE, Arts WF, Kushner SA, Silva AJ, de Zeeuw CI, Moll HA, Elgersma Y. Effect of simvastatin on cognitive functioning in children with neurofibromatosis type 1: a randomized controlled trial. Jama. 300: 287-94. PMID 18632543 DOI: 10.1001/Jama.300.3.287  0.764
2008 Olijslagers JE, de Kloet ER, Elgersma Y, van Woerden GM, Joëls M, Karst H. Rapid changes in hippocampal CA1 pyramidal cell function via pre- as well as postsynaptic membrane mineralocorticoid receptors. The European Journal of Neuroscience. 27: 2542-50. PMID 18547242 DOI: 10.1111/j.1460-9568.2008.06220.x  0.657
2008 van Engelen SJ, Krab LC, Moll HA, de Goede-Bolder A, Pluijm SM, Catsman-Berrevoets CE, Elgersma Y, Lequin MH. Quantitative differentiation between healthy and disordered brain matter in patients with neurofibromatosis type I using diffusion tensor imaging. Ajnr. American Journal of Neuroradiology. 29: 816-22. PMID 18339726 DOI: 10.3174/ajnr.A0921  0.758
2008 Park CS, Elgersma Y, Grant SG, Morrison JH. alpha-Isoform of calcium-calmodulin-dependent protein kinase II and postsynaptic density protein 95 differentially regulate synaptic expression of NR2A- and NR2B-containing N-methyl-d-aspartate receptors in hippocampus. Neuroscience. 151: 43-55. PMID 18082335 DOI: 10.1016/J.Neuroscience.2007.09.075  0.331
2008 Shilyansky C, Li W, Acosta M, Elgersma Y, Hannan F, Hardt M, Hunter-Schaedle K, Krab LC, Legius E, Wiltgen B, J Silva A. Molecular and cellular mechanisms of learning disabilities: A focus on neurofibromatosis type I Animal and Translational Models For Cns Drug Discovery. 2: 77-92. DOI: 10.1016/B978-0-12-373861-5.00015-1  0.767
2008 Elgersma Y, Krab LC, Moll HA. Statin therapy and cognitive deficits associated with neurofibromatosis type 1: Reply Jama - Journal of the American Medical Association. 300: 2369-2370. DOI: 10.1001/jama.2008.688  0.746
2007 Goorden SM, van Woerden GM, van der Weerd L, Cheadle JP, Elgersma Y. Cognitive deficits in Tsc1+/- mice in the absence of cerebral lesions and seizures. Annals of Neurology. 62: 648-55. PMID 18067135 DOI: 10.1002/ana.21317  0.769
2007 Hojjati MR, van Woerden GM, Tyler WJ, Giese KP, Silva AJ, Pozzo-Miller L, Elgersma Y. Kinase activity is not required for alphaCaMKII-dependent presynaptic plasticity at CA3-CA1 synapses. Nature Neuroscience. 10: 1125-7. PMID 17660813 DOI: 10.1038/Nn1946  0.769
2007 van Woerden GM, Harris KD, Hojjati MR, Gustin RM, Qiu S, de Avila Freire R, Jiang YH, Elgersma Y, Weeber EJ. Rescue of neurological deficits in a mouse model for Angelman syndrome by reduction of alphaCaMKII inhibitory phosphorylation. Nature Neuroscience. 10: 280-2. PMID 17259980 DOI: 10.1038/Nn1845  0.764
2006 Hansel C, de Jeu M, Belmeguenai A, Houtman SH, Buitendijk GH, Andreev D, De Zeeuw CI, Elgersma Y. alphaCaMKII Is essential for cerebellar LTD and motor learning. Neuron. 51: 835-43. PMID 16982427 DOI: 10.1016/J.Neuron.2006.08.013  0.349
2005 Kushner SA, Elgersma Y, Murphy GG, Jaarsma D, van Woerden GM, Hojjati MR, Cui Y, LeBoutillier JC, Marrone DF, Choi ES, De Zeeuw CI, Petit TL, Pozzo-Miller L, Silva AJ. Modulation of presynaptic plasticity and learning by the H-ras/extracellular signal-regulated kinase/synapsin I signaling pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 9721-34. PMID 16237176 DOI: 10.1523/Jneurosci.2836-05.2005  0.78
2005 Burguière E, Arleo A, Hojjati Mr, Elgersma Y, De Zeeuw CI, Berthoz A, Rondi-Reig L. Spatial navigation impairment in mice lacking cerebellar LTD: a motor adaptation deficit? Nature Neuroscience. 8: 1292-4. PMID 16136042 DOI: 10.1038/Nn1532  0.583
2005 Zhang L, Kirschstein T, Sommersberg B, Merkens M, Manahan-Vaughan D, Elgersma Y, Beck H. Hippocampal synaptic metaplasticity requires inhibitory autophosphorylation of Ca2+/calmodulin-dependent kinase II. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 7697-707. PMID 16107656 DOI: 10.1523/Jneurosci.2086-05.2005  0.316
2004 Elgersma Y, Sweatt JD, Giese KP. Mouse genetic approaches to investigating calcium/calmodulin-dependent protein kinase II function in plasticity and cognition. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 8410-5. PMID 15456813 DOI: 10.1523/JNEUROSCI.3622-04.2004  0.353
2003 Koekkoek SK, Hulscher HC, Dortland BR, Hensbroek RA, Elgersma Y, Ruigrok TJ, De Zeeuw CI. Cerebellar LTD and learning-dependent timing of conditioned eyelid responses. Science (New York, N.Y.). 301: 1736-9. PMID 14500987 DOI: 10.1126/Science.1088383  0.312
2003 Weeber EJ, Jiang YH, Elgersma Y, Varga AW, Carrasquillo Y, Brown SE, Christian JM, Mirnikjoo B, Silva A, Beaudet AL, Sweatt JD. Derangements of hippocampal calcium/calmodulin-dependent protein kinase II in a mouse model for Angelman mental retardation syndrome. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 2634-44. PMID 12684449 DOI: 10.1523/Jneurosci.23-07-02634.2003  0.561
2002 Kistler WM, De Jeu MT, Elgersma Y, Van Der Giessen RS, Hensbroek R, Luo C, Koekkoek SK, Hoogenraad CC, Hamers FP, Gueldenagel M, Sohl G, Willecke K, De Zeeuw CI. Analysis of Cx36 knockout does not support tenet that olivary gap junctions are required for complex spike synchronization and normal motor performance. Annals of the New York Academy of Sciences. 978: 391-404. PMID 12582068 DOI: 10.1111/J.1749-6632.2002.Tb07582.X  0.329
2002 Elgersma Y, Fedorov NB, Ikonen S, Choi ES, Elgersma M, Carvalho OM, Giese KP, Silva AJ. Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning. Neuron. 36: 493-505. PMID 12408851 DOI: 10.1016/S0896-6273(02)01007-3  0.542
2001 Silva AJ, Elgersma Y, Costa RM. From genes to therapies: The role of animal models Clinical Neuroscience Research. 1: 187-193. DOI: 10.1016/S1566-2772(01)00005-6  0.645
2000 Silva AJ, Elgersma Y, Costa RM. Molecular and cellular mechanisms of cognitive function: implications for psychiatric disorders. Biological Psychiatry. 47: 200-9. PMID 10682217 DOI: 10.1016/S0006-3223(99)00294-2  0.671
1999 Elgersma Y, Silva AJ. Molecular mechanisms of synaptic plasticity and memory. Current Opinion in Neurobiology. 9: 209-13. PMID 10322188 DOI: 10.1016/S0959-4388(99)80029-4  0.504
1998 Silva AJ, Elgersma Y, Friedman E, Stern J, Kogan J. A mouse model for learning and memory defects associated with neurofibromatosis type I. Pathologie-Biologie. 46: 697-8. PMID 9885821  0.453
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