| Year |
Citation |
Score |
| 2020 |
Slater CL, Winogrodzki J, Fraile-Ribot PA, Oliver A, Khajehpour M, Mark BL. Adding insult to injury: mechanistic basis for how AmpC mutations allow to accelerate cephalosporin hydrolysis and evade avibactam. Antimicrobial Agents and Chemotherapy. PMID 32660987 DOI: 10.1128/Aac.00894-20 |
0.364 |
|
| 2020 |
Tchesnokov EP, Bailey-Elkin BA, Mark BL, Götte M. Independent inhibition of the polymerase and deubiquitinase activities of the Crimean-Congo Hemorrhagic Fever Virus full-length L-protein. Plos Neglected Tropical Diseases. 14: e0008283. PMID 32497085 DOI: 10.1371/Journal.Pntd.0008283 |
0.332 |
|
| 2019 |
Mangat CS, Vadlamani G, Holicek V, Chu M, Larmour V, Vocadlo DJ, Mulvey MR, Mark BL. Molecular basis for the potent inhibition of the emerging carbapenemase VCC-1 by avibactam. Antimicrobial Agents and Chemotherapy. PMID 30782990 DOI: 10.1128/Aac.02112-18 |
0.355 |
|
| 2018 |
Ho LA, Winogrodzki JL, Debowski AW, Madden Z, Vocadlo DJ, Mark BL, Stubbs KA. A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to β-lactams in Pseudomonas aeruginosa. Chemical Communications (Cambridge, England). PMID 30178799 DOI: 10.2210/Pdb6Dte/Pdb |
0.335 |
|
| 2018 |
Macdonald SS, Patel A, Larmour VLC, Morgan-Lang C, Hallam SJ, Mark BL, Withers SG. Structural and mechanistic analysis of a β-glycoside phosphorylase identified by screening a metagenomic library. The Journal of Biological Chemistry. PMID 29317495 DOI: 10.1074/Jbc.Ra117.000948 |
0.351 |
|
| 2018 |
Abbott W, Alber O, Bayer E, Berrin J, Boraston A, Brumer H, Brzezinski R, Clarke A, Cobucci-Ponzano B, Cockburn D, Coutinho P, Czjzek M, Dassa B, Davies GJ, Eijsink V, ... ... Mark B, et al. Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes Glycobiology. 28: 3-8. PMID 29040563 DOI: 10.1093/Glycob/Cwx089 |
0.368 |
|
| 2017 |
Bailey-Elkin BA, Knaap RCM, Kikkert M, Mark BL. Structure and function of viral deubiquitinating enzymes. Journal of Molecular Biology. PMID 28625850 DOI: 10.1016/J.Jmb.2017.06.010 |
0.365 |
|
| 2017 |
Zhang W, Bailey-Elkin BA, Knaap RCM, Khare B, Dalebout TJ, Johnson GG, van Kasteren PB, McLeish NJ, Gu J, He W, Kikkert M, Mark BL, Sidhu SS. Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants. Plos Pathogens. 13: e1006372. PMID 28542609 DOI: 10.1371/Journal.Ppat.1006372 |
0.382 |
|
| 2017 |
Bouquet J, King DT, Vadlamani G, Benzie GR, Iorga B, Ide D, Adachi I, Kato A, Vocadlo DJ, Mark BL, Blériot Y, Désiré J. Selective trihydroxylated azepane inhibitors of NagZ, a glycosidase involved in Pseudomonas aeruginosa resistance to β-lactam antibiotics. Organic & Biomolecular Chemistry. PMID 28513749 DOI: 10.1039/C7Ob00838D |
0.324 |
|
| 2017 |
Vadlamani G, Stubbs KA, Désiré J, Blériot Y, Vocadlo DJ, Mark BL. Conformational flexibility of the glycosidase NagZ allows it to bind structurally diverse inhibitors to suppress β-lactam antibiotic resistance. Protein Science : a Publication of the Protein Society. PMID 28370529 DOI: 10.1002/Pro.3166 |
0.418 |
|
| 2016 |
Hamou-Segarra M, Zamorano L, Vadlamani G, Chu M, Sanchez-Diener I, Juan C, Blazquez J, Hattie M, Stubbs KA, Mark BL, Oliver A. Synergistic activity of fosfomycin, β-lactams and peptidoglycan recycling inhibition against Pseudomonas aeruginosa. The Journal of Antimicrobial Chemotherapy. PMID 27999022 DOI: 10.1093/Jac/Dkw456 |
0.317 |
|
| 2016 |
Santana AG, Vadlamani G, Mark BL, Withers SG. N-Acetyl glycals are tight-binding and environmentally insensitive inhibitors of hexosaminidases. Chemical Communications (Cambridge, England). 52: 7943-6. PMID 27253678 DOI: 10.1039/C6Cc02520J |
0.369 |
|
| 2016 |
Osmon KJ, Woodley E, Thompson P, Ong K, Karumuthil-Melethil S, Keimel JG, Mark BL, Mahuran D, Gray S, Walia JS. Systemic Gene Transfer of a Hexosaminidase Variant Using a scAAV9.47 Vector Corrects GM2 Gangliosidosis in Sandhoff Mice. Human Gene Therapy. PMID 27199088 DOI: 10.1089/Hum.2016.015 |
0.339 |
|
| 2016 |
Karumuthil-Melethil S, Nagabhushan Kalburgi S, Thompson P, Tropak M, Kaytor MD, Keimel JG, Mark BL, Mahuran D, Walia JS, Gray SJ. NOVEL VECTOR DESIGN AND HEXOSAMINIDASE VARIANT ENABLING SELF-COMPLEMENTARY AAV FOR THE TREATMENT OF TAY-SACHS DISEASE. Human Gene Therapy. PMID 27197548 DOI: 10.1089/Hum.2016.013 |
0.356 |
|
| 2016 |
Tropak MB, Yonekawa S, Karumuthil-Melethil S, Thompson P, Wakarchuk W, Gray SJ, Walia JS, Mark BL, Mahuran D. Construction of a hybrid β-hexosaminidase subunit capable of forming stable homodimers that hydrolyze GM2 ganglioside in vivo. Molecular Therapy. Methods & Clinical Development. 3: 15057. PMID 26966698 DOI: 10.1038/Mtm.2015.57 |
0.365 |
|
| 2016 |
Zaloba P, Bailey-Elkin BA, Derksen M, Mark BL. Structural and Biochemical Insights into the Peptidoglycan Hydrolase Domain of FlgJ from Salmonella typhimurium. Plos One. 11: e0149204. PMID 26871950 DOI: 10.1371/Journal.Pone.0149204 |
0.419 |
|
| 2015 |
Bacik JP, Klesmith JR, Whitehead TA, Jarboe LR, Unkefer CJ, Mark BL, Michalczyk R. Producing glucose-6-phosphate from cellulosic biomass: structural insights into levoglucosan bioconversion. The Journal of Biological Chemistry. PMID 26354439 DOI: 10.1074/Jbc.M115.674614 |
0.374 |
|
| 2015 |
Vadlamani G, Thomas MD, Patel TR, Donald LJ, Reeve TM, Stetefeld J, Standing KG, Vocadlo DJ, Mark BL. The β-lactamase gene regulator AmpR is a tetramer that recognizes and binds the D-Ala-D-Ala motif of its repressor UDP-N-acetylmuramic acid (MurNAc)-pentapeptide. The Journal of Biological Chemistry. 290: 2630-43. PMID 25480792 DOI: 10.2210/Pdb4Wkm/Pdb |
0.379 |
|
| 2015 |
Osmon KJ, Woodley E, Thompson P, Ong K, Karumuthil-Melethil S, Mark B, Mahuran D, Gray SJ, Walia JS. MG-110 Intravenous neonatal gene therapy corrects GM2 gangliosidoses in sandhoff mice for ‘long-term’, by using an aav expressing a new hexosaminidase variant Journal of Medical Genetics. 52: A4.2-A4. DOI: 10.1136/Jmedgenet-2015-103578.10 |
0.322 |
|
| 2015 |
Karumuthil-Melethil S, Thompson P, Walia JS, Mark B, Mahuran D, Gray SJ. 712. Improved Reduction in GM2 Ganglioside Accumulation in Tay-Sachs Mice Using a New Hexosaminidase Variant Molecular Therapy. 23: S284. DOI: 10.1016/S1525-0016(16)34321-0 |
0.345 |
|
| 2015 |
Osmon KJ, Woodley E, Thompson P, Ong K, Karumuthil-Melethil S, Mark B, Mahuran D, Gray SJ, Walia JS. 711. Intravenous Neonatal Gene Therapy Corrects GM2 Gangliosidosis in Sandhoff Mice for Long-Term, By Using AAV Viral Vector Expressing a New Hexosaminidase Variant Molecular Therapy. 23: S283-S284. DOI: 10.1016/S1525-0016(16)34320-9 |
0.392 |
|
| 2014 |
Bailey-Elkin BA, Knaap RC, Johnson GG, Dalebout TJ, Ninaber DK, van Kasteren PB, Bredenbeek PJ, Snijder EJ, Kikkert M, Mark BL. Crystal structure of the Middle East respiratory syndrome coronavirus (MERS-CoV) papain-like protease bound to ubiquitin facilitates targeted disruption of deubiquitinating activity to demonstrate its role in innate immune suppression. The Journal of Biological Chemistry. 289: 34667-82. PMID 25320088 DOI: 10.1074/Jbc.M114.609644 |
0.407 |
|
| 2014 |
Li Y, Treffers EE, Napthine S, Tas A, Zhu L, Sun Z, Bell S, Mark BL, van Veelen PA, van Hemert MJ, Firth AE, Brierley I, Snijder EJ, Fang Y. Transactivation of programmed ribosomal frameshifting by a viral protein. Proceedings of the National Academy of Sciences of the United States of America. 111: E2172-81. PMID 24825891 DOI: 10.1073/Pnas.1321930111 |
0.364 |
|
| 2014 |
Bailey-Elkin BA, van Kasteren PB, Snijder EJ, Kikkert M, Mark BL. Viral OTU deubiquitinases: a structural and functional comparison. Plos Pathogens. 10: e1003894. PMID 24676359 DOI: 10.1371/Journal.Ppat.1003894 |
0.38 |
|
| 2014 |
Bacik JP, Tavassoli M, Patel TR, McKenna SA, Vocadlo DJ, Khajehpour M, Mark BL. Conformational itinerary of Pseudomonas aeruginosa 1,6-anhydro-N-acetylmuramic acid kinase during its catalytic cycle. The Journal of Biological Chemistry. 289: 4504-14. PMID 24362022 DOI: 10.1074/Jbc.M113.521633 |
0.385 |
|
| 2014 |
Bacik J, Broom-Peltz B, Jarboe L, Mark B, Michalczyk R, Fisher Z, Unkefer C. Structure and mechanism of LGK: insights into the bioconversion of levoglucosan Acta Crystallographica Section a Foundations and Advances. 70: C1205-C1205. DOI: 10.1107/S2053273314087944 |
0.35 |
|
| 2014 |
Bailey-Elkin B, Kasteren Pv, Snijder E, Kikkert M, Mark B. Nidovirus papain-like proteases antagonize the host innate immune response Acta Crystallographica Section A. 70. DOI: 10.1107/S2053273314084010 |
0.394 |
|
| 2013 |
Mondon M, Hur S, Vadlamani G, Rodrigues P, Tsybina P, Oliver A, Mark BL, Vocadlo DJ, Blériot Y. Selective trihydroxyazepane NagZ inhibitors increase sensitivity of Pseudomonas aeruginosa to β-lactams. Chemical Communications (Cambridge, England). 49: 10983-5. PMID 24136176 DOI: 10.1039/C3Cc46646A |
0.32 |
|
| 2013 |
Stubbs KA, Bacik JP, Perley-Robertson GE, Whitworth GE, Gloster TM, Vocadlo DJ, Mark BL. The development of selective inhibitors of NagZ: increased susceptibility of Gram-negative bacteria to β-lactams. Chembiochem : a European Journal of Chemical Biology. 14: 1973-81. PMID 24009110 DOI: 10.1002/Cbic.201300395 |
0.362 |
|
| 2013 |
Sinici I, Yonekawa S, Tkachyova I, Gray SJ, Samulski RJ, Wakarchuk W, Mark BL, Mahuran DJ. In cellulo examination of a beta-alpha hybrid construct of beta-hexosaminidase A subunits, reported to interact with the GM2 activator protein and hydrolyze GM2 ganglioside. Plos One. 8: e57908. PMID 23483939 DOI: 10.1371/Journal.Pone.0057908 |
0.405 |
|
| 2013 |
van Kasteren PB, Bailey-Elkin BA, James TW, Ninaber DK, Beugeling C, Khajehpour M, Snijder EJ, Mark BL, Kikkert M. Deubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cells. Proceedings of the National Academy of Sciences of the United States of America. 110: E838-47. PMID 23401522 DOI: 10.1073/Pnas.1218464110 |
0.398 |
|
| 2012 |
Bacik JP, Whitworth GE, Stubbs KA, Vocadlo DJ, Mark BL. Active site plasticity within the glycoside hydrolase NagZ underlies a dynamic mechanism of substrate distortion. Chemistry & Biology. 19: 1471-82. PMID 23177201 DOI: 10.1016/J.Chembiol.2012.09.016 |
0.411 |
|
| 2011 |
Mark BL, Vocadlo DJ, Oliver A. Providing β-lactams a helping hand: targeting the AmpC β-lactamase induction pathway. Future Microbiology. 6: 1415-27. PMID 22122439 DOI: 10.2217/Fmb.11.128 |
0.352 |
|
| 2011 |
Pedelacq JD, Nguyen HB, Cabantous S, Mark BL, Listwan P, Bell C, Friedland N, Lockard M, Faille A, Mourey L, Terwilliger TC, Waldo GS. Experimental mapping of soluble protein domains using a hierarchical approach. Nucleic Acids Research. 39: e125. PMID 21771856 DOI: 10.1093/Nar/Gkr548 |
0.326 |
|
| 2011 |
Zamorano L, Reeve TM, Juan C, Moyá B, Cabot G, Vocadlo DJ, Mark BL, Oliver A. AmpG inactivation restores susceptibility of pan-beta-lactam-resistant Pseudomonas aeruginosa clinical strains. Antimicrobial Agents and Chemotherapy. 55: 1990-6. PMID 21357303 DOI: 10.1128/Aac.01688-10 |
0.331 |
|
| 2011 |
Bacik JP, Whitworth GE, Stubbs KA, Yadav AK, Martin DR, Bailey-Elkin BA, Vocadlo DJ, Mark BL. Molecular basis of 1,6-anhydro bond cleavage and phosphoryl transfer by Pseudomonas aeruginosa 1,6-anhydro-N-acetylmuramic acid kinase. The Journal of Biological Chemistry. 286: 12283-91. PMID 21288904 DOI: 10.1074/Jbc.M110.198317 |
0.359 |
|
| 2011 |
James TW, Frias-Staheli N, Bacik JP, Levingston Macleod JM, Khajehpour M, García-Sastre A, Mark BL. Structural basis for the removal of ubiquitin and interferon-stimulated gene 15 by a viral ovarian tumor domain-containing protease. Proceedings of the National Academy of Sciences of the United States of America. 108: 2222-7. PMID 21245344 DOI: 10.1073/Pnas.1013388108 |
0.423 |
|
| 2010 |
Balcewich MD, Reeve TM, Orlikow EA, Donald LJ, Vocadlo DJ, Mark BL. Crystal structure of the AmpR effector binding domain provides insight into the molecular regulation of inducible ampc beta-lactamase. Journal of Molecular Biology. 400: 998-1010. PMID 20594961 DOI: 10.1016/J.Jmb.2010.05.040 |
0.441 |
|
| 2010 |
Zamorano L, Reeve TM, Deng L, Juan C, Moyá B, Cabot G, Vocadlo DJ, Mark BL, Oliver A. NagZ inactivation prevents and reverts beta-lactam resistance, driven by AmpD and PBP 4 mutations, in Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy. 54: 3557-63. PMID 20566764 DOI: 10.1128/Aac.00385-10 |
0.38 |
|
| 2009 |
Balcewich MD, Stubbs KA, He Y, James TW, Davies GJ, Vocadlo DJ, Mark BL. Insight into a strategy for attenuating AmpC-mediated beta-lactam resistance: structural basis for selective inhibition of the glycoside hydrolase NagZ. Protein Science : a Publication of the Protein Society. 18: 1541-51. PMID 19499593 DOI: 10.1002/Pro.137 |
0.436 |
|
| 2009 |
Armistead J, Khatkar S, Meyer B, Mark BL, Patel N, Coghlan G, Lamont RE, Liu S, Wiechert J, Cattini PA, Koetter P, Wrogemann K, Greenberg CR, Entian KD, Zelinski T, et al. Mutation of a gene essential for ribosome biogenesis, EMG1, causes Bowen-Conradi syndrome. American Journal of Human Genetics. 84: 728-39. PMID 19463982 DOI: 10.1016/J.Ajhg.2009.04.017 |
0.341 |
|
| 2009 |
Asgarali A, Stubbs KA, Oliver A, Vocadlo DJ, Mark BL. Inactivation of the glycoside hydrolase NagZ attenuates antipseudomonal beta-lactam resistance in Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy. 53: 2274-82. PMID 19273679 DOI: 10.1128/Aac.01617-08 |
0.404 |
|
| 2008 |
Stubbs KA, Scaffidi A, Debowski AW, Mark BL, Stick RV, Vocadlo DJ. Synthesis and use of mechanism-based protein-profiling probes for retaining beta-D-glucosaminidases facilitate identification of Pseudomonas aeruginosa NagZ. Journal of the American Chemical Society. 130: 327-35. PMID 18067297 DOI: 10.1021/Ja0763605 |
0.438 |
|
| 2007 |
Stubbs KA, Balcewich M, Mark BL, Vocadlo DJ. Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC-mediated beta-lactam resistance. The Journal of Biological Chemistry. 282: 21382-91. PMID 17439950 DOI: 10.1074/Jbc.M700084200 |
0.393 |
|
| 2006 |
Lemieux MJ, Mark BL, Cherney MM, Withers SG, Mahuran DJ, James MN. Crystallographic structure of human beta-hexosaminidase A: interpretation of Tay-Sachs mutations and loss of GM2 ganglioside hydrolysis. Journal of Molecular Biology. 359: 913-29. PMID 16698036 DOI: 10.1016/J.Jmb.2006.04.004 |
0.609 |
|
| 2003 |
Mark BL, Mahuran DJ, Cherney MM, Zhao D, Knapp S, James MN. Crystal structure of human beta-hexosaminidase B: understanding the molecular basis of Sandhoff and Tay-Sachs disease. Journal of Molecular Biology. 327: 1093-109. PMID 12662933 DOI: 10.1016/S0022-2836(03)00216-X |
0.56 |
|
| 2002 |
Williams SJ, Mark BL, Vocadlo DJ, James MN, Withers SG. Aspartate 313 in the Streptomyces plicatus hexosaminidase plays a critical role in substrate-assisted catalysis by orienting the 2-acetamido group and stabilizing the transition state. The Journal of Biological Chemistry. 277: 40055-65. PMID 12171933 DOI: 10.1074/Jbc.M206481200 |
0.527 |
|
| 2002 |
Barrette-Ng IH, Ng KK, Mark BL, Van Aken D, Cherney MM, Garen C, Kolodenko Y, Gorbalenya AE, Snijder EJ, James MN. Structure of arterivirus nsp4. The smallest chymotrypsin-like proteinase with an alpha/beta C-terminal extension and alternate conformations of the oxyanion hole. The Journal of Biological Chemistry. 277: 39960-6. PMID 12163505 DOI: 10.1074/Jbc.M206978200 |
0.667 |
|
| 2002 |
Mark BL, James MN. Anchimeric assistance in hexosaminidases Canadian Journal of Chemistry. 80: 1064-1074. DOI: 10.1139/V02-130 |
0.526 |
|
| 2002 |
Mark BL, Vocadlo DJ, Zhao D, Knapp S, Withers SG, James MNG. Biochemical and structural assessment of the 1-N-azasugar GalNAc-isofagomine as a potent family 20 β-hexosaminidase inhibitor Acta Crystallographica Section a Foundations of Crystallography. 58: c106-c106. DOI: 10.1107/S0108767302089274 |
0.324 |
|
| 2001 |
Mark BL, Vocadlo DJ, Zhao D, Knapp S, Withers SG, James MN. Biochemical and structural assessment of the 1-N-azasugar GalNAc-isofagomine as a potent family 20 beta-N-acetylhexosaminidase inhibitor. The Journal of Biological Chemistry. 276: 42131-7. PMID 11522797 DOI: 10.1074/Jbc.M107154200 |
0.522 |
|
| 2001 |
Mark BL, Parrish JC, Wang ZX, Wiebe LI, Knaus EE, James MN. (E)-1-(2'-deoxy-beta-D-ribofuranosyl)-2,4-difluoro-5-(2-iodovinyl)benzene. Acta Crystallographica. Section C, Crystal Structure Communications. 57: 758-60. PMID 11408697 DOI: 10.1107/S0108270101005029 |
0.44 |
|
| 2001 |
Mark BL, Vocadlo DJ, Knapp S, Triggs-Raine BL, Withers SG, James MN. Crystallographic evidence for substrate-assisted catalysis in a bacterial beta-hexosaminidase. The Journal of Biological Chemistry. 276: 10330-7. PMID 11124970 DOI: 10.1074/Jbc.M011067200 |
0.546 |
|
| 1998 |
Mark BL, Wasney GA, Salo TJ, Khan AR, Cao Z, Robbins PW, James MN, Triggs-Raine BL. Structural and functional characterization of Streptomyces plicatus beta-N-acetylhexosaminidase by comparative molecular modeling and site-directed mutagenesis. The Journal of Biological Chemistry. 273: 19618-24. PMID 9677388 DOI: 10.1074/Jbc.273.31.19618 |
0.599 |
|
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