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Leigh C. Carmody - Publications

Affiliations: 
Chemical Biology Platform Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, United States 
Area:
High throughput screening
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9/40 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Chattopadhyay S, Stewart AL, Mukherjee S, Huang C, Hartwell KA, Miller PG, Subramanian R, Carmody LC, Yusuf RZ, Sykes DB, Paulk J, Vetere A, Vallet S, Santo L, Cirstea DD, et al. Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors. Cell Reports. PMID 25660025 DOI: 10.1016/J.Celrep.2015.01.017  0.39
2012 Dykhuizen EC, Carmody LC, Tolliday N, Crabtree GR, Palmer MA. Screening for inhibitors of an essential chromatin remodeler in mouse embryonic stem cells by monitoring transcriptional regulation. Journal of Biomolecular Screening. 17: 1221-30. PMID 22853929 DOI: 10.1177/1087057112455060  0.355
2010 Baucum AJ, Jalan-Sakrikar N, Jiao Y, Gustin RM, Carmody LC, Tabb DL, Ham AJ, Colbran RJ. Identification and validation of novel spinophilin-associated proteins in rodent striatum using an enhanced ex vivo shotgun proteomics approach. Molecular & Cellular Proteomics : McP. 9: 1243-59. PMID 20124353 DOI: 10.1074/Mcp.M900387-Mcp200  0.611
2008 Carmody LC, Baucum AJ, Bass MA, Colbran RJ. Selective targeting of the gamma1 isoform of protein phosphatase 1 to F-actin in intact cells requires multiple domains in spinophilin and neurabin. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 1660-71. PMID 18216290 DOI: 10.1096/Fj.07-092841  0.599
2005 Robison AJ, Bass MA, Jiao Y, MacMillan LB, Carmody LC, Bartlett RK, Colbran RJ. Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2. The Journal of Biological Chemistry. 280: 35329-36. PMID 16120608 DOI: 10.1074/Jbc.M502191200  0.62
2004 Carmody LC, Bauman PA, Bass MA, Mavila N, DePaoli-Roach AA, Colbran RJ. A protein phosphatase-1gamma1 isoform selectivity determinant in dendritic spine-associated neurabin. The Journal of Biological Chemistry. 279: 21714-23. PMID 15016827 DOI: 10.1074/jbc.M402261200  0.595
2003 Colbran RJ, Carmody LC, Bauman PA, Wadzinski BE, Bass MA. Analysis of specific interactions of native protein phosphatase 1 isoforms with targeting subunits. Methods in Enzymology. 366: 156-75. PMID 14674248 DOI: 10.1016/S0076-6879(03)66014-3  0.618
2003 Colbran RJ, Carmody LC, Bauman PA, Wadzinski BE, Bass MA. [14] Analysis of Specific Interactions of Native Protein Phosphatase 1 Isoforms with Targeting Subunits Methods in Enzymology. 366: 156-175. DOI: 10.1016/S0076-6879(03)66014-3  0.592
2002 Terry-Lorenzo RT, Carmody LC, Voltz JW, Connor JH, Li S, Smith FD, Milgram SL, Colbran RJ, Shenolikar S. The neuronal actin-binding proteins, neurabin I and neurabin II, recruit specific isoforms of protein phosphatase-1 catalytic subunits. The Journal of Biological Chemistry. 277: 27716-24. PMID 12016225 DOI: 10.1074/Jbc.M203365200  0.622
Low-probability matches (unlikely to be authored by this person)
2012 Carmody LC, Germain AR, VerPlank L, Nag PP, Muñoz B, Perez JR, Palmer MA. Phenotypic high-throughput screening elucidates target pathway in breast cancer stem cell-like cells. Journal of Biomolecular Screening. 17: 1204-10. PMID 22941295 DOI: 10.1177/1087057112458317  0.298
2014 Dandapani S, Germain AR, Jewett I, le Quement S, Marie JC, Muncipinto G, Duvall JR, Carmody LC, Perez JR, Engel JC, Gut J, Kellar D, Siqueira-Neto JL, McKerrow JH, Kaiser M, et al. Diversity-oriented synthesis yields a new drug lead for treatment of chagas disease. Acs Medicinal Chemistry Letters. 5: 149-53. PMID 24900788 DOI: 10.1021/Ml400403U  0.291
2011 Germain AR, Carmody LC, Dockendorff C, Galan-Rodriguez C, Rodriguez A, Johnston S, Bittker JA, MacPherson L, Dandapani S, Palmer M, Schreiber SL, Munoz B. Identification of small-molecule inhibitors of Trypansoma cruzi replication. Bioorganic & Medicinal Chemistry Letters. 21: 7197-200. PMID 22018462 DOI: 10.1016/J.Bmcl.2011.09.057  0.28
2013 Germain AR, Carmody LC, Nag PP, Morgan B, Verplank L, Fernandez C, Donckele E, Feng Y, Perez JR, Dandapani S, Palmer M, Lander ES, Gupta PB, Schreiber SL, Munoz B. Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells. Bioorganic & Medicinal Chemistry Letters. 23: 1834-8. PMID 23403082 DOI: 10.1016/J.Bmcl.2013.01.025  0.275
2012 Germain AR, Carmody LC, Morgan B, Fernandez C, Forbeck E, Lewis TA, Nag PP, Ting A, VerPlank L, Feng Y, Perez JR, Dandapani S, Palmer M, Lander ES, Gupta PB, et al. Identification of a selective small molecule inhibitor of breast cancer stem cells. Bioorganic & Medicinal Chemistry Letters. 22: 3571-4. PMID 22503247 DOI: 10.1016/J.Bmcl.2012.01.035  0.275
2020 Carmody LC, Blau H, Danis D, Zhang XA, Gourdine JP, Vasilevsky N, Krawitz P, Thompson MD, Robinson PN. Significantly different clinical phenotypes associated with mutations in synthesis and transamidase+remodeling glycosylphosphatidylinositol (GPI)-anchor biosynthesis genes. Orphanet Journal of Rare Diseases. 15: 40. PMID 32019583 DOI: 10.1186/s13023-020-1313-0  0.247
2019 Köhler S, Øien NC, Buske OJ, Groza T, Jacobsen JOB, McNamara C, Vasilevsky N, Carmody LC, Gourdine JP, Gargano M, McMurry JA, Danis D, Mungall CJ, Smedley D, Haendel M, et al. Encoding Clinical Data with the Human Phenotype Ontology for Computational Differential Diagnostics. Current Protocols in Human Genetics. 103: e92. PMID 31479590 DOI: 10.1002/Cphg.92  0.239
2018 Köhler S, Carmody L, Vasilevsky N, Jacobsen JOB, Danis D, Gourdine JP, Gargano M, Harris NL, Matentzoglu N, McMurry JA, Osumi-Sutherland D, Cipriani V, Balhoff JP, Conlin T, Blau H, et al. Expansion of the Human Phenotype Ontology (HPO) knowledge base and resources. Nucleic Acids Research. PMID 30476213 DOI: 10.1093/Nar/Gky1105  0.238
2012 Chattopadhyay S, Stewart AL, Mukherjee S, Huang C, Hartwell KA, Miller PG, Carmody L, Yusuf RZ, Sykes DB, Vallet S, Santo L, Cirstea DD, Hideshima T, Dancik V, Cheah J, et al. Niche-Based Screening Identifies Novel Small Molecules That Overcome Stromal Effects in Multiple Myeloma Blood. 120: 571-571. DOI: 10.1182/Blood.V120.21.571.571  0.234
2020 Robinson PN, Ravanmehr V, Jacobsen JOB, Danis D, Zhang XA, Carmody LC, Gargano MA, Thaxton CL, Karlebach G, Reese J, Holtgrewe M, Köhler S, McMurry JA, Haendel MA, et al. Interpretable Clinical Genomics with a Likelihood Ratio Paradigm. American Journal of Human Genetics. PMID 32755546 DOI: 10.1016/j.ajhg.2020.06.021  0.23
2020 Atalaia A, Thompson R, Corvo A, Carmody L, Piscia D, Matalonga L, Macaya A, Lochmuller A, Fontaine B, Zurek B, Hernandez-Ferrer C, Rheinard C, Gómez-Andrés D, Desaphy JF, Schon K, et al. A guide to writing systematic reviews of rare disease treatments to generate FAIR-compliant datasets: building a Treatabolome. Orphanet Journal of Rare Diseases. 15: 206. PMID 32787960 DOI: 10.1186/s13023-020-01493-7  0.215
2023 Sundaramurthi JC, Bagley AM, Blau H, Carmody L, Crandall A, Danis D, Gargano M, Gustafson AG, Raney EM, Shingle M, Davids JR, Robinson PN. De novo TRPM3 missense variant associated with neurodevelopmental delay and manifestations of cerebral palsy. Cold Spring Harbor Molecular Case Studies. PMID 37684057 DOI: 10.1101/mcs.a006293  0.199
2018 Vasilevsky NA, Foster ED, Engelstad ME, Carmody L, Might M, Chambers C, Dawkins HJS, Lewis J, Della Rocca MG, Snyder M, Boerkoel CF, Rath A, Terry SF, Kent A, Searle B, et al. Plain-language medical vocabulary for precision diagnosis. Nature Genetics. 50: 474-476. PMID 29632381 DOI: 10.1038/S41588-018-0096-X  0.181
2021 Ravanmehr V, Blau H, Cappelletti L, Fontana T, Carmody L, Coleman B, George J, Reese J, Joachimiak M, Bocci G, Hansen P, Bult C, Rueter J, Casiraghi E, Valentini G, et al. Supervised learning with word embeddings derived from PubMed captures latent knowledge about protein kinases and cancer. Nar Genomics and Bioinformatics. 3: lqab113. PMID 34888523 DOI: 10.1093/nargab/lqab113  0.155
2021 Danis D, Jacobsen JOB, Carmody LC, Gargano MA, McMurry JA, Hegde A, Haendel MA, Valentini G, Smedley D, Robinson PN. Interpretable prioritization of splice variants in diagnostic next-generation sequencing. American Journal of Human Genetics. PMID 34289339 DOI: 10.1016/j.ajhg.2021.06.014  0.143
2023 Carmody LC, Gargano MA, Toro S, Vasilevsky NA, Adam MP, Blau H, Chan LE, Gomez-Andres D, Horvath R, Kraus ML, Ladewig MS, Lewis-Smith D, Lochmüller H, Matentzoglu NA, Munoz-Torres MC, et al. The Medical Action Ontology: A Tool for Annotating and Analyzing Treatments and Clinical Management of Human Disease. Medrxiv : the Preprint Server For Health Sciences. PMID 37503136 DOI: 10.1101/2023.07.13.23292612  0.127
2023 Karlebach G, Carmody L, Sundaramurthi JC, Casiraghi E, Hansen P, Reese J, Mungall CJ, Valentini G, Robinson PN. An expectation-maximization framework for comprehensive prediction of isoform-specific functions. Bioinformatics (Oxford, England). PMID 36929917 DOI: 10.1093/bioinformatics/btad132  0.125
2019 Shefchek KA, Harris NL, Gargano M, Matentzoglu N, Unni D, Brush M, Keith D, Conlin T, Vasilevsky N, Zhang XA, Balhoff JP, Babb L, Bello SM, Blau H, Bradford Y, ... ... Carmody L, et al. The Monarch Initiative in 2019: an integrative data and analytic platform connecting phenotypes to genotypes across species. Nucleic Acids Research. PMID 31701156 DOI: 10.1093/nar/gkz997  0.121
2023 Danis D, Jacobsen JOB, Wagner AH, Groza T, Beckwith MA, Rekerle L, Carmody LC, Reese J, Hegde H, Ladewig MS, Seitz B, Munoz-Torres M, Harris NL, Rambla J, Baudis M, et al. Phenopacket-tools: Building and validating GA4GH Phenopackets. Plos One. 18: e0285433. PMID 37196000 DOI: 10.1371/journal.pone.0285433  0.113
2020 Köhler S, Gargano M, Matentzoglu N, Carmody LC, Lewis-Smith D, Vasilevsky NA, Danis D, Balagura G, Baynam G, Brower AM, Callahan TJ, Chute CG, Est JL, Galer PD, Ganesan S, et al. The Human Phenotype Ontology in 2021. Nucleic Acids Research. PMID 33264411 DOI: 10.1093/nar/gkaa1043  0.108
2022 Dhombres F, Morgan P, Chaudhari BP, Filges I, Sparks TN, Lapunzina P, Roscioli T, Agarwal U, Aggarwal S, Beneteau C, Cacheiro P, Carmody LC, Collardeau-Frachon S, Dempsey EA, Dufke A, et al. Prenatal phenotyping: A community effort to enhance the Human Phenotype Ontology. American Journal of Medical Genetics. Part C, Seminars in Medical Genetics. PMID 35872606 DOI: 10.1002/ajmg.c.31989  0.105
2023 Gargano MA, Matentzoglu N, Coleman B, Addo-Lartey EB, Anagnostopoulos AV, Anderton J, Avillach P, Bagley AM, Bakštein E, Balhoff JP, Baynam G, Bello SM, Berk M, Bertram H, Bishop S, ... ... Carmody LC, et al. The Human Phenotype Ontology in 2024: phenotypes around the world. Nucleic Acids Research. PMID 37953324 DOI: 10.1093/nar/gkad1005  0.103
2021 Danis D, Jacobsen JOB, Carmody LC, Gargano MA, McMurry JA, Hegde A, Haendel MA, Valentini G, Smedley D, Robinson PN. Interpretable prioritization of splice variants in diagnostic next-generation sequencing. American Journal of Human Genetics. 108: 2205. PMID 34739835 DOI: 10.1016/j.ajhg.2021.09.014  0.094
2022 Horak P, Griffith M, Danos AM, Pitel BA, Madhavan S, Liu X, Chow C, Williams H, Carmody L, Barrow-Laing L, Rieke D, Kreutzfeldt S, Stenzinger A, Tamborero D, Benary M, et al. Standards for the classification of pathogenicity of somatic variants in cancer (oncogenicity): Joint recommendations of Clinical Genome Resource (ClinGen), Cancer Genomics Consortium (CGC), and Variant Interpretation for Cancer Consortium (VICC). Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 35101336 DOI: 10.1016/j.gim.2022.01.001  0.093
2021 Deer RR, Rock MA, Vasilevsky N, Carmody L, Rando H, Anzalone AJ, Basson MD, Bennett TD, Bergquist T, Boudreau EA, Bramante CT, Byrd JB, Callahan TJ, Chan LE, Chu H, et al. Characterizing Long COVID: Deep Phenotype of a Complex Condition. Ebiomedicine. 74: 103722. PMID 34839263 DOI: 10.1016/j.ebiom.2021.103722  0.071
2019 Zhang XA, Yates A, Vasilevsky N, Gourdine JP, Callahan TJ, Carmody LC, Danis D, Joachimiak MP, Ravanmehr V, Pfaff ER, Champion J, Robasky K, Xu H, Fecho K, Walton NA, et al. Semantic integration of clinical laboratory tests from electronic health records for deep phenotyping and biomarker discovery. Npj Digital Medicine. 2. PMID 31119199 DOI: 10.1038/s41746-019-0110-4  0.068
2023 Carmody LC, Gargano MA, Toro S, Vasilevsky NA, Adam MP, Blau H, Chan LE, Gomez-Andres D, Horvath R, Kraus ML, Ladewig MS, Lewis-Smith D, Lochmüller H, Matentzoglu NA, Munoz-Torres MC, et al. The Medical Action Ontology: A tool for annotating and analyzing treatments and clinical management of human disease. Med (New York, N.Y.). PMID 37963467 DOI: 10.1016/j.medj.2023.10.003  0.058
2022 Lin AY, Yamagata Y, Duncan WD, Carmody LC, Kushida T, Masuya H, Beverley J, Dutta B, DeBellis M, Pendlington ZM, Roncaglia P, He Y. A community effort for COVID-19 Ontology Harmonization. Ceur Workshop Proceedings. 3073: 122-127. PMID 37324543  0.055
2022 Horak P, Griffith M, Danos AM, Pitel BA, Madhavan S, Liu X, Chow C, Williams H, Carmody L, Barrow-Laing L, Rieke D, Kreutzfeldt S, Stenzinger A, Tamborero D, Benary M, et al. Standards for the classification of pathogenicity of somatic variants in cancer (oncogenicity): Joint recommendations of Clinical Genome Resource (ClinGen), Cancer Genomics Consortium (CGC), and Variant Interpretation for Cancer Consortium (VICC). Genetics in Medicine : Official Journal of the American College of Medical Genetics. 24: 1991. PMID 36063163 DOI: 10.1016/j.gim.2022.07.001  0.051
2021 Atalaia A, Thompson R, Corvo A, Carmody L, Piscia D, Matalonga L, Macaya A, Lochmuller A, Fontaine B, Zurek B, Hernandez-Ferrer C, Reinhard C, Gómez-Andrés D, Desaphy JF, Schon K, et al. Correction to: A guide to writing systematic reviews of rare disease treatments to generate FAIRcompliant datasets: building a Treatabolome. Orphanet Journal of Rare Diseases. 16: 145. PMID 33752678 DOI: 10.1186/s13023-021-01777-6  0.039
2024 Cappelletti L, Rekerle L, Fontana T, Hansen P, Casiraghi E, Ravanmehr V, Mungall CJ, Yang JJ, Spranger L, Karlebach G, Caufield JH, Carmody L, Coleman B, Oprea TI, Reese J, et al. Node-degree aware edge sampling mitigates inflated classification performance in biomedical random walk-based graph representation learning. Bioinformatics Advances. 4: vbae036. PMID 38577542 DOI: 10.1093/bioadv/vbae036  0.028
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