Julio Fernandez - Publications

Affiliations: 
Columbia University, New York, NY 

122 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Alonso-Caballero A, Echelman DJ, Tapia-Rojo R, Haldar S, Eckels EC, Fernandez JM. Protein folding modulates the chemical reactivity of a Gram-positive adhesin. Nature Chemistry. PMID 33257887 DOI: 10.1038/s41557-020-00586-x  0.829
2020 Tapia-Rojo R, Alonso-Caballero Á, Fernández JM. Talin folding as the tuning fork of cellular mechanotransduction. Proceedings of the National Academy of Sciences of the United States of America. PMID 32817549 DOI: 10.1073/Pnas.2004091117  0.84
2020 Tapia-Rojo R, Alonso-Caballero A, Fernandez JM. Direct observation of a coil-to-helix contraction triggered by vinculin binding to talin. Science Advances. 6: eaaz4707. PMID 32494739 DOI: 10.1126/Sciadv.Aaz4707  0.823
2020 Rivas-Pardo JA, Li Y, Mártonfalvi Z, Tapia-Rojo R, Unger A, Fernández-Trasancos Á, Herrero-Galán E, Velázquez-Carreras D, Fernández JM, Linke WA, Alegre-Cebollada J. A HaloTag-TEV genetic cassette for mechanical phenotyping of proteins from tissues. Nature Communications. 11: 2060. PMID 32345978 DOI: 10.1038/S41467-020-15465-9  0.87
2020 Alonso-Caballero A, Tapia-Rojo R, Badilla CL, Fernandez JM. High Force Magnetic Tweezers Reveal That Bacterial Adhesion Pili Act as Megadalton-scale Schock Absorbers Biophysical Journal. 118: 33a-34a. DOI: 10.1016/J.Bpj.2019.11.361  0.809
2019 Eckels EC, Haldar S, Tapia-Rojo R, Rivas-Pardo JA, Fernández JM. The Mechanical Power of Titin Folding. Cell Reports. 27: 1836-1847.e4. PMID 31067467 DOI: 10.1016/J.Celrep.2019.04.046  0.846
2019 Tapia-Rojo R, Eckels EC, Fernández JM. Ephemeral states in protein folding under force captured with a magnetic tweezers design. Proceedings of the National Academy of Sciences of the United States of America. PMID 30936303 DOI: 10.1073/Pnas.1821284116  0.837
2019 Echelman DJ, Alonso A, Haldar S, Tapia-Rojo R, Eckels EC, Fernandez JM. Mechanical Forces are a Reactivity Switch for an Adhesin Thioester Bond Biophysical Journal. 116: 544a. DOI: 10.1016/J.Bpj.2018.11.2927  0.832
2018 Rivas-Pardo JA, Badilla CL, Tapia-Rojo R, Alonso-Caballero Á, Fernández JM. Molecular strategy for blocking isopeptide bond formation in nascent pilin proteins. Proceedings of the National Academy of Sciences of the United States of America. PMID 30150415 DOI: 10.1073/Pnas.1807689115  0.832
2018 Berkovich R, Fernandez VI, Stirnemann G, Valle-Orero J, Fernandez JM. Segmentation and the Entropic Elasticity of Modular Proteins. The Journal of Physical Chemistry Letters. PMID 30058807 DOI: 10.1021/Acs.Jpclett.8B01925  0.812
2018 Eckels EC, Tapia-Rojo R, Rivas-Pardo JA, Fernández JM. The Work of Titin Protein Folding as a Major Driver in Muscle Contraction. Annual Review of Physiology. 80: 327-351. PMID 29433413 DOI: 10.1146/Annurev-Physiol-021317-121254  0.841
2018 Giganti D, Yan K, Badilla CL, Fernandez JM, Alegre-Cebollada J. Disulfide isomerization reactions in titin immunoglobulin domains enable a mode of protein elasticity. Nature Communications. 9: 185. PMID 29330363 DOI: 10.1038/S41467-017-02528-7  0.718
2017 Haldar S, Tapia-Rojo R, Eckels EC, Valle-Orero J, Fernandez JM. Trigger factor chaperone acts as a mechanical foldase. Nature Communications. 8: 668. PMID 28939815 DOI: 10.1038/S41467-017-00771-6  0.857
2017 Valle-Orero J, Tapia-Rojo R, Eckels EC, Rivas-Pardo JA, Popa I, Fernandez JM. Proteins Breaking Bad: A Free Energy Perspective. The Journal of Physical Chemistry Letters. PMID 28723106 DOI: 10.1021/Acs.Jpclett.7B01509  0.823
2017 Valle Orero J, Rivas-Pardo JA, Tapia-Rojo R, Popa I, Echelman DJ, Haldar S, Fernandez JM. Mechanical deformation accelerates protein ageing. Angewandte Chemie (International Ed. in English). PMID 28470663 DOI: 10.1002/Anie.201703630  0.821
2017 Echelman DJ, Lee AQ, Fernández JM. Mechanical forces regulate the reactivity of a thioester bond in a bacterial adhesin. The Journal of Biological Chemistry. PMID 28348083 DOI: 10.1074/jbc.M117.777466  0.845
2017 Alonso-Caballero A, Andres Rivas-Pardo J, Badilla CL, Echelman DJ, Fernandez JM. A Lego Toolbox for Engineering Proteins for Single Molecule Force Spectroscopy Biophysical Journal. 112: 300a. DOI: 10.1016/J.Bpj.2016.11.1624  0.847
2016 Popa I, Rivas-Pardo JA, Eckels EC, Echelman D, Valle-Orero J, Fernandez JM. A HaloTag Anchored Ruler for Week-Long Studies of Protein Dynamics. Journal of the American Chemical Society. PMID 27409974 DOI: 10.1021/Jacs.6B05429  0.828
2016 Echelman DJ, Alegre-Cebollada J, Badilla CL, Chang C, Ton-That H, Fernández JM. CnaA domains in bacterial pili are efficient dissipaters of large mechanical shocks. Proceedings of the National Academy of Sciences of the United States of America. PMID 26884173 DOI: 10.1073/Pnas.1522946113  0.857
2016 Rivas-Pardo JA, Eckels EC, Popa I, Kosuri P, Linke WA, Fernández JM. Work Done by Titin Protein Folding Assists Muscle Contraction. Cell Reports. PMID 26854230 DOI: 10.1016/J.Celrep.2016.01.025  0.82
2016 Echelman D, Fernandez J. Force Spectroscopy of a Bacterial Adhesin with an Internal Thioester Bond Biophysical Journal. 110. DOI: 10.1016/J.Bpj.2015.11.2508  0.846
2016 Eckels EC, Andres Rivas-Pardo J, Valle-Orero J, Popa I, Fernandez JM. The Science of Stretching: Mechanical Anisotropy in Titin Ig Domains Biophysical Journal. 110: 393a. DOI: 10.1016/J.Bpj.2015.11.2123  0.835
2015 Garcia-Manyes S, Giganti D, Badilla CL, Lezamiz A, Perales-Calvo J, Beedle AE, Fernández JM. Single molecule force spectroscopy predicts a misfolded, domain-swapped conformation in human γD-crystallin. The Journal of Biological Chemistry. PMID 26703476 DOI: 10.1074/Jbc.M115.673871  0.751
2015 Saqlain F, Popa I, Fernández JM, Alegre-Cebollada J. A novel strategy for utilizing voice coil servoactuators in tensile tests of low volume protein hydrogels. Macromolecular Materials and Engineering. 300: 369-376. PMID 25960689 DOI: 10.1002/Mame.201400271  0.786
2015 Kahn TB, Fernández JM, Perez-Jimenez R. Monitoring Oxidative Folding of a Single Protein Catalyzed by the Disulfide Oxidoreductase DsbA. The Journal of Biological Chemistry. 290: 14518-27. PMID 25897077 DOI: 10.1074/Jbc.M115.646000  0.822
2015 Rivas-Pardo JA, Alegre-Cebollada J, Ramírez-Sarmiento CA, Fernandez JM, Guixé V. Identifying sequential substrate binding at the single-molecule level by enzyme mechanical stabilization. Acs Nano. 9: 3996-4005. PMID 25840594 DOI: 10.1021/Nn507480V  0.697
2015 Valle-Orero J, Eckels EC, Stirnemann G, Popa I, Berkovich R, Fernandez JM. The elastic free energy of a tandem modular protein under force. Biochemical and Biophysical Research Communications. 460: 434-8. PMID 25796331 DOI: 10.1016/J.Bbrc.2015.03.051  0.838
2015 Chen H, Yuan G, Winardhi RS, Yao M, Popa I, Fernandez JM, Yan J. Dynamics of equilibrium folding and unfolding transitions of titin immunoglobulin domain under constant forces. Journal of the American Chemical Society. 137: 3540-6. PMID 25726700 DOI: 10.1021/Ja5119368  0.759
2015 Popa I, Rivas-Pardo JA, Eckels EC, Valle-Orero J, Kahn TB, Berkovich R, Stirnemann G, Chen H, Fernandez VI, Berne BJ, Yan J, Fernandez JM. Revisiting the Free Energy of Modular Proteins under Force Biophysical Journal. 108: 355a. DOI: 10.1016/J.Bpj.2014.11.1944  0.862
2014 Perez-Jimenez R, Alonso-Caballero A, Berkovich R, Franco D, Chen MW, Richard P, Badilla CL, Fernandez JM. Probing the effect of force on HIV-1 receptor CD4. Acs Nano. 8: 10313-20. PMID 25299596 DOI: 10.1021/Nn503557W  0.807
2014 Solsona C, Kahn TB, Badilla CL, Álvarez-Zaldiernas C, Blasi J, Fernandez JM, Alegre-Cebollada J. Altered thiol chemistry in human amyotrophic lateral sclerosis-linked mutants of superoxide dismutase 1. The Journal of Biological Chemistry. 289: 26722-32. PMID 25096579 DOI: 10.1074/Jbc.M114.565333  0.675
2014 Alegre-Cebollada J, Kosuri P, Giganti D, Eckels E, Rivas-Pardo JA, Hamdani N, Warren CM, Solaro RJ, Linke WA, Fernández JM. S-glutathionylation of cryptic cysteines enhances titin elasticity by blocking protein folding. Cell. 156: 1235-46. PMID 24630725 DOI: 10.1016/J.Cell.2014.01.056  0.801
2014 Echelman D, Alegre-Cebollada J, Squyres G, Fernandez C, Chang C, Ton-That H, Fernandez J. Surviving a Bumpy Ride in the Oropharynx: Bacterial Pili as Nano-Seatbelts that Dissipate Mechanical Energy Biophysical Journal. 106: 578a. DOI: 10.1016/J.Bpj.2013.11.3205  0.858
2014 Alegre-Cebollada J, Kosuri P, Giganti D, Eckels E, Rivas-Pardo JA, Hamdani N, Linke WA, Fernández JM. Large-Scale Modulation of Titin Elasticity by S-Glutathionylation of Cryptic Cysteines Biophysical Journal. 106: 454a. DOI: 10.1016/J.Bpj.2013.11.2570  0.814
2014 Giganti D, Stirnemann G, Yan K, Berne B, Fernandez J. Disulfide Bonds are Allosteric Regulator of Mechanical Stability Biophysical Journal. 106: 449a-450a. DOI: 10.1016/J.Bpj.2013.11.2548  0.578
2014 Fernandez J. Posttranslational Modifications as Modulators of Mechanical Protein Folding Biophysical Journal. 106. DOI: 10.1016/J.Bpj.2013.11.2511  0.606
2013 Giganti D, Alegre-Cebollada J, Urresti S, Albesa-Jové D, Rodrigo-Unzueta A, Comino N, Kachala M, López-Fernández S, Svergun DI, Fernández JM, Guerin ME. Conformational plasticity of the essential membrane-associated mannosyltransferase PimA from mycobacteria. The Journal of Biological Chemistry. 288: 29797-808. PMID 23963451 DOI: 10.1074/Jbc.M113.462705  0.722
2013 Ingles-Prieto A, Ibarra-Molero B, Delgado-Delgado A, Perez-Jimenez R, Fernandez JM, Gaucher EA, Sanchez-Ruiz JM, Gavira JA. Conservation of protein structure over four billion years Structure. 21: 1690-1697. PMID 23932589 DOI: 10.1016/J.Str.2013.06.020  0.8
2013 Popa I, Berkovich R, Alegre-Cebollada J, Badilla CL, Rivas-Pardo JA, Taniguchi Y, Kawakami M, Fernandez JM. Nanomechanics of HaloTag tethers. Journal of the American Chemical Society. 135: 12762-71. PMID 23909704 DOI: 10.1021/Ja4056382  0.855
2013 Popa I, Kosuri P, Alegre-Cebollada J, Garcia-Manyes S, Fernandez JM. Force dependency of biochemical reactions measured by single-molecule force-clamp spectroscopy. Nature Protocols. 8: 1261-76. PMID 23744288 DOI: 10.1038/Nprot.2013.056  0.848
2013 Stirnemann G, Giganti D, Fernandez JM, Berne BJ. Elasticity, structure, and relaxation of extended proteins under force. Proceedings of the National Academy of Sciences of the United States of America. 110: 3847-52. PMID 23407163 DOI: 10.1073/Pnas.1300596110  0.504
2013 Javadi Y, Fernandez JM, Perez-Jimenez R. Protein folding under mechanical forces: a physiological view. Physiology (Bethesda, Md.). 28: 9-17. PMID 23280353 DOI: 10.1152/Physiol.00017.2012  0.864
2013 Fernandez J. Single Molecule Enzymology Biophysical Journal. 104. DOI: 10.1016/J.Bpj.2012.11.045  0.545
2012 Kosuri P, Alegre-Cebollada J, Feng J, Kaplan A, Inglés-Prieto A, Badilla CL, Stockwell BR, Sanchez-Ruiz JM, Holmgren A, Fernández JM. Protein folding drives disulfide formation. Cell. 151: 794-806. PMID 23141538 DOI: 10.1016/J.Cell.2012.09.036  0.821
2012 Berkovich R, Hermans RI, Popa I, Stirnemann G, Garcia-Manyes S, Berne BJ, Fernandez JM. Rate limit of protein elastic response is tether dependent. Proceedings of the National Academy of Sciences of the United States of America. 109: 14416-21. PMID 22895787 DOI: 10.1073/Pnas.1212167109  0.837
2012 Garcia-Manyes S, Badilla CL, Alegre-Cebollada J, Javadi Y, Fernández JM. Spontaneous dimerization of titin protein Z1Z2 domains induces strong nanomechanical anchoring. The Journal of Biological Chemistry. 287: 20240-7. PMID 22523089 DOI: 10.1074/Jbc.M112.355883  0.844
2012 Jimenez RP, Berkovich R, Richard P, Badilla C, Fernandez J. Molecular Mechanotransduction in Human CD4 Biophysical Journal. 102: 3-4. DOI: 10.1016/J.Bpj.2011.11.2101  0.368
2012 Berkovich R, Hermans RI, Garcia-Manyes S, Fernandez JM. Direct Measurement of the Diffusion Dynamics of an Extended Poly-Ubiquitin Under Constant Force Biophysical Journal. 102: 12a. DOI: 10.1016/J.Bpj.2011.11.090  0.847
2012 Alegre-Cebollada J, Sánchez-Romero I, Rivas-Pardo JA, Regunath K, Badilla CL, Fernández JM. Towards a General Platform to Study Single-Bond Chemistry Under Force Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.086  0.756
2011 Alegre-Cebollada J, Kosuri P, Rivas-Pardo JA, Fernández JM. Direct observation of disulfide isomerization in a single protein. Nature Chemistry. 3: 882-7. PMID 22024885 DOI: 10.1038/Nchem.1155  0.845
2011 Popa I, Fernández JM, Garcia-Manyes S. Direct quantification of the attempt frequency determining the mechanical unfolding of ubiquitin protein. The Journal of Biological Chemistry. 286: 31072-9. PMID 21768096 DOI: 10.1074/Jbc.M111.264093  0.82
2011 Dougan L, Genchev GZ, Lu H, Fernandez JM. Probing osmolyte participation in the unfolding transition state of a protein. Proceedings of the National Academy of Sciences of the United States of America. 108: 9759-64. PMID 21613570 DOI: 10.1073/Pnas.1101934108  0.754
2011 Alegre-Cebollada J, Kosuri P, Fernández JM. Protease power strokes force proteins to unfold. Cell. 145: 339-40. PMID 21529709 DOI: 10.1016/J.Cell.2011.04.007  0.808
2011 Perez-Jimenez R, Inglés-Prieto A, Zhao ZM, Sanchez-Romero I, Alegre-Cebollada J, Kosuri P, Garcia-Manyes S, Kappock TJ, Tanokura M, Holmgren A, Sanchez-Ruiz JM, Gaucher EA, Fernandez JM. Single-molecule paleoenzymology probes the chemistry of resurrected enzymes. Nature Structural & Molecular Biology. 18: 592-6. PMID 21460845 DOI: 10.1038/Nsmb.2020  0.801
2011 Liang J, Fernández JM. Kinetic measurements on single-molecule disulfide bond cleavage. Journal of the American Chemical Society. 133: 3528-34. PMID 21341766 DOI: 10.1021/ja109684q  0.354
2011 Garcia-Manyes S, Kuo TL, Fernández JM. Contrasting the individual reactive pathways in protein unfolding and disulfide bond reduction observed within a single protein. Journal of the American Chemical Society. 133: 3104-13. PMID 21309561 DOI: 10.1021/Ja109865Z  0.734
2011 Popa I, Garcia-Manyes S, Fernandez JM. Temperature Dependence of the Mechanical Unfolding of Single Ubiquitin Proteins Biophysical Journal. 100: 398a. DOI: 10.1016/J.Bpj.2010.12.2362  0.827
2010 Berkovich R, Garcia-Manyes S, Klafter J, Urbakh M, Fernández JM. Hopping around an entropic barrier created by force. Biochemical and Biophysical Research Communications. 403: 133-7. PMID 21050839 DOI: 10.1016/J.Bbrc.2010.10.133  0.756
2010 Li J, Fernandez JM, Berne BJ. Water's role in the force-induced unfolding of ubiquitin. Proceedings of the National Academy of Sciences of the United States of America. 107: 19284-9. PMID 20974922 DOI: 10.1073/Pnas.1013159107  0.44
2010 Kuo TL, Garcia-Manyes S, Li J, Barel I, Lu H, Berne BJ, Urbakh M, Klafter J, Fernández JM. Probing static disorder in Arrhenius kinetics by single-molecule force spectroscopy. Proceedings of the National Academy of Sciences of the United States of America. 107: 11336-40. PMID 20534507 DOI: 10.1073/Pnas.1006517107  0.722
2010 Berkovich R, Garcia-Manyes S, Urbakh M, Klafter J, Fernandez JM. Collapse dynamics of single proteins extended by force. Biophysical Journal. 98: 2692-701. PMID 20513414 DOI: 10.1016/J.Bpj.2010.02.053  0.764
2010 Rodriguez-Larrea D, Perez-Jimenez R, Sanchez-Romero I, Delgado-Delgado A, Fernandez JM, Sanchez-Ruiz JM. Role of conservative mutations in protein multi-property adaptation. The Biochemical Journal. 429: 243-9. PMID 20446918 DOI: 10.1042/Bj20100386  0.824
2010 Alegre-Cebollada J, Perez-Jimenez R, Kosuri P, Fernandez JM. Single-molecule force spectroscopy approach to enzyme catalysis. The Journal of Biological Chemistry. 285: 18961-6. PMID 20382731 DOI: 10.1074/Jbc.R109.011932  0.832
2010 Alegre-Cebollada J, Badilla CL, Fernández JM. Isopeptide bonds block the mechanical extension of pili in pathogenic Streptococcus pyogenes. The Journal of Biological Chemistry. 285: 11235-42. PMID 20139067 DOI: 10.1074/Jbc.M110.102962  0.765
2010 Fernandez JM, Garcia-Manyes S, Dougan L. Force-clamp spectroscopy of single proteins Springer Series in Chemical Physics. 96: 318-335. DOI: 10.1002/9783527626137.ch13  0.768
2009 Garcia-Manyes S, Liang J, Szoszkiewicz R, Kuo TL, Fernández JM. Force-activated reactivity switch in a bimolecular chemical reaction. Nature Chemistry. 1: 236-42. PMID 21378854 DOI: 10.1038/Nchem.207  0.763
2009 Fernandez VI, Kosuri P, Parot V, Fernandez JM. Extended Kalman filter estimates the contour length of a protein in single molecule atomic force microscopy experiments. The Review of Scientific Instruments. 80: 113104. PMID 19947714 DOI: 10.1063/1.3252982  0.768
2009 Grützner A, Garcia-Manyes S, Kötter S, Badilla CL, Fernandez JM, Linke WA. Modulation of titin-based stiffness by disulfide bonding in the cardiac titin N2-B unique sequence. Biophysical Journal. 97: 825-34. PMID 19651040 DOI: 10.1016/J.Bpj.2009.05.037  0.695
2009 Perez-Jimenez R, Li J, Kosuri P, Sanchez-Romero I, Wiita AP, Rodriguez-Larrea D, Chueca A, Holmgren A, Miranda-Vizuete A, Becker K, Cho SH, Beckwith J, Gelhaye E, Jacquot JP, Gaucher EA, ... ... Fernandez JM, et al. Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy. Nature Structural & Molecular Biology. 16: 890-6. PMID 19597482 DOI: 10.1038/Nsmb.1627  0.853
2009 Liang J, Fernández JM. Mechanochemistry: one bond at a time. Acs Nano. 3: 1628-45. PMID 19572737 DOI: 10.1021/nn900294n  0.432
2009 Dougan L, Li J, Badilla CL, Berne BJ, Fernandez JM. Single homopolypeptide chains collapse into mechanically rigid conformations. Proceedings of the National Academy of Sciences of the United States of America. 106: 12605-10. PMID 19549822 DOI: 10.1073/Pnas.0900678106  0.723
2009 Garcia-Manyes S, Dougan L, Badilla CL, Brujic J, Fernández JM. Direct observation of an ensemble of stable collapsed states in the mechanical folding of ubiquitin. Proceedings of the National Academy of Sciences of the United States of America. 106: 10534-9. PMID 19541635 DOI: 10.1073/Pnas.0901213106  0.832
2009 Garcia-Manyes S, Dougan L, Fernández JM. Osmolyte-induced separation of the mechanical folding phases of ubiquitin. Proceedings of the National Academy of Sciences of the United States of America. 106: 10540-5. PMID 19541633 DOI: 10.1073/Pnas.0902090106  0.821
2009 Liu R, Garcia-Manyes S, Sarkar A, Badilla CL, Fernández JM. Mechanical characterization of protein L in the low-force regime by electromagnetic tweezers/evanescent nanometry. Biophysical Journal. 96: 3810-21. PMID 19413987 DOI: 10.1016/J.Bpj.2009.01.043  0.779
2009 del Rio A, Perez-Jimenez R, Liu R, Roca-Cusachs P, Fernandez JM, Sheetz MP. Stretching single talin rod molecules activates vinculin binding. Science (New York, N.Y.). 323: 638-41. PMID 19179532 DOI: 10.1126/Science.1162912  0.85
2009 Liu R, Garcia-Manyes S, Sarkar A, Badilla CL, Fernandez JM. Platform AY: Emerging Single Molecule Techniques IIMechanical characterization of Protein L in the low-force regime by electromagnetic tweezers/evanescent nanometry Biophysical Journal. DOI: 10.1016/J.Bpj.2008.12.3650  0.716
2009 Rodriguez-Larrea D, Perez-Jimenez R, Sanchez-Romero I, Arco-Gonzalez R, Delgado A, Fernandez JM, Sanchez-Ruiz JM. Super-proteins From Fitness-threshold Selection Statistics Biophysical Journal. 96. DOI: 10.1016/J.Bpj.2008.12.3098  0.822
2009 Kuo T, Badilla CL, Fernandez JM. Investigating The Mechanical Stability Of Sap-1 Transcription Factor By Single Molecule Force Spectroscopy Biophysical Journal. 96. DOI: 10.1016/J.Bpj.2008.12.3075  0.333
2009 Fernandez J. Chemistry under Force Biophysical Journal. 96. DOI: 10.1016/J.Bpj.2008.12.2871  0.502
2009 Garcia-Manyes S, Dougan L, Badilla CL, Brujic J, Fernandez J. Revisiting Protein Folding at the Single Molecule Level Biophysical Journal. 96: 217a. DOI: 10.1016/J.Bpj.2008.12.1903  0.837
2009 Garcia-Manyes S, Liang J, Fernandez JM. Direct Identification of Two Distinct Transition State Structures in Reduction of a Disulfide Bond Revealed by Single Bond Force-clamp Spectroscopy Biophysical Journal. 96: 37a. DOI: 10.1016/J.Bpj.2008.12.085  0.718
2009 Liang J, Fernandez JM. The Temperature Dependency of Disulfide Bond Reduction Events Measured by Single-molecule Force Clamp Spectroscopy Biophysical Journal. 96: 37a. DOI: 10.1016/j.bpj.2008.12.084  0.348
2008 Dougan L, Koti AS, Genchev G, Lu H, Fernandez JM. A single-molecule perspective on the role of solvent hydrogen bonds in protein folding and chemical reactions. Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. 9: 2836-47. PMID 19058277 DOI: 10.1002/Cphc.200800572  0.691
2008 Perez-Jimenez R, Wiita AP, Rodriguez-Larrea D, Kosuri P, Gavira JA, Sanchez-Ruiz JM, Fernandez JM. Force-clamp spectroscopy detects residue co-evolution in enzyme catalysis. The Journal of Biological Chemistry. 283: 27121-9. PMID 18687682 DOI: 10.1074/Jbc.M803746200  0.806
2008 Koti Ainavarapu SR, Wiita AP, Dougan L, Uggerud E, Fernandez JM. Single-molecule force spectroscopy measurements of bond elongation during a bimolecular reaction. Journal of the American Chemical Society. 130: 6479-87. PMID 18433129 DOI: 10.1021/Ja800180U  0.817
2008 Dougan L, Feng G, Lu H, Fernandez JM. Solvent molecules bridge the mechanical unfolding transition state of a protein. Proceedings of the National Academy of Sciences of the United States of America. 105: 3185-90. PMID 18305176 DOI: 10.1073/Pnas.0706075105  0.706
2008 Ainavarapu SR, Wiita AP, Huang HH, Fernandez JM. A single-molecule assay to directly identify solvent-accessible disulfide bonds and probe their effect on protein folding. Journal of the American Chemical Society. 130: 436-7. PMID 18088123 DOI: 10.1021/Ja077851S  0.844
2008 Szoszkiewicz R, Ainavarapu SR, Wiita AP, Perez-Jimenez R, Sanchez-Ruiz JM, Fernandez JM. Dwell time analysis of a single-molecule mechanochemical reaction. Langmuir : the Acs Journal of Surfaces and Colloids. 24: 1356-64. PMID 17999545 DOI: 10.1021/La702368B  0.82
2007 Dougan L, Fernandez JM. Tandem repeating modular proteins avoid aggregation in single molecule force spectroscopy experiments. The Journal of Physical Chemistry. A. 111: 12402-8. PMID 18020430 DOI: 10.1021/Jp076095+  0.711
2007 Wiita AP, Perez-Jimenez R, Walther KA, Gräter F, Berne BJ, Holmgren A, Sanchez-Ruiz JM, Fernandez JM. Probing the chemistry of thioredoxin catalysis with force. Nature. 450: 124-7. PMID 17972886 DOI: 10.1038/Nature06231  0.825
2007 Garcia-Manyes S, Brujić J, Badilla CL, Fernández JM. Force-clamp spectroscopy of single-protein monomers reveals the individual unfolding and folding pathways of I27 and ubiquitin. Biophysical Journal. 93: 2436-46. PMID 17545242 DOI: 10.1529/Biophysj.107.104422  0.786
2007 Walther KA, Gräter F, Dougan L, Badilla CL, Berne BJ, Fernandez JM. Signatures of hydrophobic collapse in extended proteins captured with force spectroscopy. Proceedings of the National Academy of Sciences of the United States of America. 104: 7916-21. PMID 17470816 DOI: 10.1073/Pnas.0702179104  0.865
2007 Brujic J, Hermans RI, Garcia-Manyes S, Walther KA, Fernandez JM. Dwell-time distribution analysis of polyprotein unfolding using force-clamp spectroscopy. Biophysical Journal. 92: 2896-903. PMID 17259284 DOI: 10.1529/Biophysj.106.099481  0.85
2007 Sarkar A, Caamano S, Fernandez JM. The mechanical fingerprint of a parallel polyprotein dimer. Biophysical Journal. 92: L36-8. PMID 17158577 DOI: 10.1529/biophysj.106.097741  0.405
2007 Ainavarapu SR, Brujic J, Huang HH, Wiita AP, Lu H, Li L, Walther KA, Carrion-Vazquez M, Li H, Fernandez JM. Contour length and refolding rate of a small protein controlled by engineered disulfide bonds. Biophysical Journal. 92: 225-33. PMID 17028145 DOI: 10.1529/Biophysj.106.091561  0.815
2006 Perez-Jimenez R, Garcia-Manyes S, Ainavarapu SR, Fernandez JM. Mechanical unfolding pathways of the enhanced yellow fluorescent protein revealed by single molecule force spectroscopy. The Journal of Biological Chemistry. 281: 40010-4. PMID 17082195 DOI: 10.1074/Jbc.M609890200  0.825
2006 Ainavarapu SR, Li L, Fernandez JM. Fingerprinting DHFR in single-molecule AFM studies. Biophysical Journal. 91: 2009-10, discussion . PMID 16782796 DOI: 10.1529/Biophysj.106.085126  0.843
2006 Wiita AP, Ainavarapu SR, Huang HH, Fernandez JM. Force-dependent chemical kinetics of disulfide bond reduction observed with single-molecule techniques. Proceedings of the National Academy of Sciences of the United States of America. 103: 7222-7. PMID 16645035 DOI: 10.1073/Pnas.0511035103  0.869
2006 Walther KA, Brujić J, Li H, Fernández JM. Sub-angstrom conformational changes of a single molecule captured by AFM variance analysis. Biophysical Journal. 90: 3806-12. PMID 16500987 DOI: 10.1529/Biophysj.105.076224  0.842
2006 Li L, Wetzel S, Plückthun A, Fernandez JM. Stepwise unfolding of ankyrin repeats in a single protein revealed by atomic force microscopy. Biophysical Journal. 90: L30-2. PMID 16387766 DOI: 10.1529/Biophysj.105.078436  0.478
2005 Sato T, Esaki M, Fernandez JM, Endo T. Comparison of the protein-unfolding pathways between mitochondrial protein import and atomic-force microscopy measurements. Proceedings of the National Academy of Sciences of the United States of America. 102: 17999-8004. PMID 16326810 DOI: 10.1073/pnas.0504495102  0.346
2005 Ainavarapu SR, Li L, Badilla CL, Fernandez JM. Ligand binding modulates the mechanical stability of dihydrofolate reductase. Biophysical Journal. 89: 3337-44. PMID 16100277 DOI: 10.1529/Biophysj.105.062034  0.827
2005 Sarkar A, Caamano S, Fernandez JM. The elasticity of individual titin PEVK exons measured by single molecule atomic force microscopy. The Journal of Biological Chemistry. 280: 6261-4. PMID 15632200 DOI: 10.1074/jbc.C400573200  0.335
2004 Sarkar A, Robertson RB, Fernandez JM. Simultaneous atomic force microscope and fluorescence measurements of protein unfolding using a calibrated evanescent wave. Proceedings of the National Academy of Sciences of the United States of America. 101: 12882-6. PMID 15326308 DOI: 10.1073/pnas.0403534101  0.32
2004 Schlierf M, Li H, Fernandez JM. The unfolding kinetics of ubiquitin captured with single-molecule force-clamp techniques. Proceedings of the National Academy of Sciences of the United States of America. 101: 7299-304. PMID 15123816 DOI: 10.1073/Pnas.0400033101  0.508
2004 Fernandez JM, Li H. Force-clamp spectroscopy monitors the folding trajectory of a single protein. Science (New York, N.Y.). 303: 1674-8. PMID 15017000 DOI: 10.1126/science.1092497  0.543
2004 Fernandez JM. Response to Comment on "Force-Clamp Spectroscopy Monitors the Folding Trajectory of a Single Protein" Science. 306: 411c-411c. DOI: 10.1126/Science.1102236  0.461
2003 Li H, Fernandez JM. Mechanical design of the first proximal Ig domain of human cardiac titin revealed by single molecule force spectroscopy. Journal of Molecular Biology. 334: 75-86. PMID 14596801 DOI: 10.1016/j.jmb.2003.09.036  0.348
2003 Marszalek PE, Oberhauser AF, Li H, Fernandez JM. The force-driven conformations of heparin studied with single molecule force microscopy. Biophysical Journal. 85: 2696-704. PMID 14507732 DOI: 10.1016/S0006-3495(03)74692-X  0.737
2003 Kenniston JA, Baker TA, Fernandez JM, Sauer RT. Linkage between ATP consumption and mechanical unfolding during the protein processing reactions of an AAA+ degradation machine. Cell. 114: 511-20. PMID 12941278 DOI: 10.1016/S0092-8674(03)00612-3  0.315
2003 Carrion-Vazquez M, Li H, Lu H, Marszalek PE, Oberhauser AF, Fernandez JM. The mechanical stability of ubiquitin is linkage dependent. Nature Structural Biology. 10: 738-43. PMID 12923571 DOI: 10.1038/Nsb965  0.744
2002 Linke WA, Fernandez JM. Cardiac titin: molecular basis of elasticity and cellular contribution to elastic and viscous stiffness components in myocardium. Journal of Muscle Research and Cell Motility. 23: 483-97. PMID 12785099 DOI: 10.1023/A:1023462507254  0.397
2002 Li H, Linke WA, Oberhauser AF, Carrion-Vazquez M, Kerkvliet JG, Lu H, Marszalek PE, Fernandez JM. Reverse engineering of the giant muscle protein titin. Nature. 418: 998-1002. PMID 12198551 DOI: 10.1038/Nature00938  0.673
2002 Oberhauser AF, Badilla-Fernandez C, Carrion-Vazquez M, Fernandez JM. The mechanical hierarchies of fibronectin observed with single-molecule AFM Journal of Molecular Biology. 319: 433-447. PMID 12051919 DOI: 10.1016/S0022-2836(02)00306-6  0.675
2002 Marszalek PE, Li H, Oberhauser AF, Fernandez JM. Chair-boat transitions in single polysaccharide molecules observed with force-ramp AFM Proceedings of the National Academy of Sciences of the United States of America. 99: 4278-4283. PMID 11917130 DOI: 10.1073/Pnas.072435699  0.726
2001 Fernandez JM, Chu S, Oberhauser AF. RNA structure: Putting on hair(pins) Science. 292: 653-654. PMID 11330326 DOI: 10.1126/Science.1060884  0.561
2001 Oberhauser AF, Hansma PK, Carrion-Vazquez M, Fernandez JM. Stepwise unfolding of titin under force-clamp atomic force microscopy Proceedings of the National Academy of Sciences of the United States of America. 98: 468-472. PMID 11149943 DOI: 10.1073/Pnas.98.2.468  0.743
1999 Marszalek PE, Lu H, Li H, Carrion-Vazquez M, Oberhauser AF, Schulten K, Fernandez JM. Mechanical unfolding intermediates in titin modules Nature. 402: 100-103. PMID 10573426 DOI: 10.1038/47083  0.726
1999 Oberhauser AF, Marszalek PE, Carrion-Vazquez M, Fernandez JM. Single protein misfolding events captured by atomic force microscopy Nature Structural Biology. 6: 1025-1028. PMID 10542093 DOI: 10.1038/14907  0.729
1998 Marszalek PE, Oberhauser AF, Pang YP, Fernandez JM. Polysaccharide elasticity governed by chair-boat transitions of the glucopyranose ring. Nature. 396: 661-4. PMID 9872313 DOI: 10.1038/25322  0.65
1998 Oberhauser AF, Marszalek PE, Erickson HP, Fernandez JM. The molecular elasticity of the extracellular matrix protein tenascin. Nature. 393: 181-5. PMID 9603523 DOI: 10.1038/30270  0.71
1993 Alvarez de Toledo G, Fernández-Chacón R, Fernández JM. Release of secretory products during transient vesicle fusion. Nature. 363: 554-8. PMID 8505984 DOI: 10.1038/363554a0  0.65
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