Lucia Sivilotti - Publications

Affiliations: 
University College London, London, United Kingdom 

66 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Safar F, Hurdiss E, Erotocritou M, Greiner T, Lape R, Irvine MW, Fang G, Jane D, Yu R, Dämgen MA, Biggin PC, Sivilotti LG. The startle disease mutation E103K impairs activation of human homomeric α1 glycine receptors by disrupting an intersubunit salt bridge across the agonist binding site. The Journal of Biological Chemistry. PMID 28174298 DOI: 10.1074/jbc.M116.767616  0.88
2016 Groot-Kormelink PJ, Ferrand S, Kelley N, Bill A, Freuler F, Imbert PE, Marelli A, Gerwin N, Sivilotti LG, Miraglia L, Orth AP, Oakeley EJ, Schopfer U, Siehler S. High Throughput Random Mutagenesis and Single Molecule Real Time Sequencing of the Muscle Nicotinic Acetylcholine Receptor. Plos One. 11: e0163129. PMID 27649498 DOI: 10.1371/journal.pone.0163129  1
2016 Epstein M, Calderhead B, Girolami MA, Sivilotti LG. Bayesian Statistical Inference in Ion-Channel Models with Exact Missed Event Correction. Biophysical Journal. 111: 333-48. PMID 27463136 DOI: 10.1016/j.bpj.2016.04.053  1
2016 Sivilotti L, Colquhoun D. In praise of single channel kinetics. The Journal of General Physiology. PMID 27432998 DOI: 10.1085/jgp.201611649  1
2015 Marabelli A, Lape R, Sivilotti L. Mechanism of activation of the prokaryotic channel ELIC by propylamine: a single-channel study. The Journal of General Physiology. 145: 23-45. PMID 25548135 DOI: 10.1085/jgp.201411234  1
2014 Yu R, Hurdiss E, Greiner T, Lape R, Sivilotti L, Biggin PC. Agonist and antagonist binding in human glycine receptors. Biochemistry. 53: 6041-51. PMID 25184435 DOI: 10.1021/bi500815f  1
2013 Calderhead B, Epstein M, Sivilotti L, Girolami M. Bayesian approaches for mechanistic ion channel modeling. Methods in Molecular Biology (Clifton, N.J.). 1021: 247-72. PMID 23715989 DOI: 10.1007/978-1-62703-450-0_13  1
2013 Marabelli A, Moroni M, Lape R, Sivilotti LG. The kinetic properties of the α3 rat glycine receptor make it suitable for mediating fast synaptic inhibition. The Journal of Physiology. 591: 3289-308. PMID 23613537 DOI: 10.1113/jphysiol.2013.252189  1
2012 Zimmermann I, Marabelli A, Bertozzi C, Sivilotti LG, Dutzler R. Inhibition of the prokaryotic pentameric ligand-gated ion channel ELIC by divalent cations. Plos Biology. 10: e1001429. PMID 23185134 DOI: 10.1371/journal.pbio.1001429  1
2012 Lape R, Plested AJ, Moroni M, Colquhoun D, Sivilotti LG. The α1K276E startle disease mutation reveals multiple intermediate states in the gating of glycine receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 1336-52. PMID 22279218 DOI: 10.1523/JNEUROSCI.4346-11.2012  1
2011 Moroni M, Biro I, Giugliano M, Vijayan R, Biggin PC, Beato M, Sivilotti LG. Chloride ions in the pore of glycine and GABA channels shape the time course and voltage dependence of agonist currents. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 14095-106. PMID 21976494 DOI: 10.1523/JNEUROSCI.1985-11.2011  1
2011 Moroni M, Meyer JO, Lahmann C, Sivilotti LG. In glycine and GABA(A) channels, different subunits contribute asymmetrically to channel conductance via residues in the extracellular domain. The Journal of Biological Chemistry. 286: 13414-22. PMID 21343294 DOI: 10.1074/jbc.M110.204610  1
2011 Krashia P, Lape R, Lodesani F, Colquhoun D, Sivilotti LG. The long activations of α2 glycine channels can be described by a mechanism with reaction intermediates ("flip"). The Journal of General Physiology. 137: 197-216. PMID 21282399 DOI: 10.1085/jgp.201010521  1
2010 Krashia P, Moroni M, Broadbent S, Hofmann G, Kracun S, Beato M, Groot-Kormelink PJ, Sivilotti LG. Human α3β4 neuronal nicotinic receptors show different stoichiometry if they are expressed in Xenopus oocytes or mammalian HEK293 cells. Plos One. 5: e13611. PMID 21049012 DOI: 10.1371/journal.pone.0013611  1
2010 Sivilotti LG. What single-channel analysis tells us of the activation mechanism of ligand-gated channels: the case of the glycine receptor. The Journal of Physiology. 588: 45-58. PMID 19770192 DOI: 10.1113/jphysiol.2009.178525  1
2009 Lape R, Krashia P, Colquhoun D, Sivilotti LG. Agonist and blocking actions of choline and tetramethylammonium on human muscle acetylcholine receptors. The Journal of Physiology. 587: 5045-72. PMID 19752108 DOI: 10.1113/jphysiol.2009.176305  1
2009 Houston CM, Bright DP, Sivilotti LG, Beato M, Smart TG. Intracellular chloride ions regulate the time course of GABA-mediated inhibitory synaptic transmission. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 10416-23. PMID 19692617 DOI: 10.1523/JNEUROSCI.1670-09.2009  1
2008 Pitt SJ, Sivilotti LG, Beato M. High intracellular chloride slows the decay of glycinergic currents. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 11454-67. PMID 18987182 DOI: 10.1523/JNEUROSCI.3890-08.2008  1
2008 Lape R, Colquhoun D, Sivilotti LG. On the nature of partial agonism in the nicotinic receptor superfamily. Nature. 454: 722-7. PMID 18633353 DOI: 10.1038/nature07139  1
2007 Plested AJ, Groot-Kormelink PJ, Colquhoun D, Sivilotti LG. Single-channel study of the spasmodic mutation alpha1A52S in recombinant rat glycine receptors. The Journal of Physiology. 581: 51-73. PMID 17331994 DOI: 10.1113/jphysiol.2006.126920  1
2007 Beato M, Sivilotti LG. Single-channel properties of glycine receptors of juvenile rat spinal motoneurones in vitro. The Journal of Physiology. 580: 497-506. PMID 17272347 DOI: 10.1113/jphysiol.2006.125740  1
2007 Beato M, Burzomato V, Sivilotti LG. The kinetics of inhibition of rat recombinant heteromeric alpha1beta glycine receptors by the low-affinity antagonist SR-95531. The Journal of Physiology. 580: 171-9. PMID 17218350 DOI: 10.1113/jphysiol.2006.126888  1
2006 Broadbent S, Groot-Kormelink PJ, Krashia PA, Harkness PC, Millar NS, Beato M, Sivilotti LG. Incorporation of the beta3 subunit has a dominant-negative effect on the function of recombinant central-type neuronal nicotinic receptors. Molecular Pharmacology. 70: 1350-7. PMID 16822928 DOI: 10.1124/mol.106.026682  1
2006 Groot-Kormelink PJ, Broadbent S, Beato M, Sivilotti LG. Constraining the expression of nicotinic acetylcholine receptors by using pentameric constructs. Molecular Pharmacology. 69: 558-63. PMID 16269534 DOI: 10.1124/mol.105.019356  1
2004 Burzomato V, Beato M, Groot-Kormelink PJ, Colquhoun D, Sivilotti LG. Single-channel behavior of heteromeric alpha1beta glycine receptors: an attempt to detect a conformational change before the channel opens. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 10924-40. PMID 15574743 DOI: 10.1523/JNEUROSCI.3424-04.2004  1
2004 Colquhoun D, Sivilotti LG. Function and structure in glycine receptors and some of their relatives. Trends in Neurosciences. 27: 337-44. PMID 15165738 DOI: 10.1016/j.tins.2004.04.010  1
2004 Groot-Kormelink PJ, Broadbent SD, Boorman JP, Sivilotti LG. Incomplete incorporation of tandem subunits in recombinant neuronal nicotinic receptors. The Journal of General Physiology. 123: 697-708. PMID 15148328 DOI: 10.1085/jgp.200409042  1
2004 Beato M, Groot-Kormelink PJ, Colquhoun D, Sivilotti LG. The activation mechanism of alpha1 homomeric glycine receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 895-906. PMID 14749434 DOI: 10.1523/JNEUROSCI.4420-03.2004  1
2003 Burzomato V, Groot-Kormelink PJ, Sivilotti LG, Beato M. Stoichiometry of recombinant heteromeric glycine receptors revealed by a pore-lining region point mutation. Receptors & Channels. 9: 353-61. PMID 14698963  1
2003 Boorman JP, Beato M, Groot-Kormelink PJ, Broadbent SD, Sivilotti LG. The effects of beta3 subunit incorporation on the pharmacology and single channel properties of oocyte-expressed human alpha3beta4 neuronal nicotinic receptors. The Journal of Biological Chemistry. 278: 44033-40. PMID 12912995 DOI: 10.1074/jbc.M211719200  1
2002 Beato M, Groot-Kormelink PJ, Colquhoun D, Sivilotti LG. Openings of the rat recombinant alpha 1 homomeric glycine receptor as a function of the number of agonist molecules bound. The Journal of General Physiology. 119: 443-66. PMID 11981023 DOI: 10.1085/jgp.20028530  1
2002 Groot-Kormelink PJ, Beato M, Finotti C, Harvey RJ, Sivilotti LG. Achieving optimal expression for single channel recording: a plasmid ratio approach to the expression of alpha 1 glycine receptors in HEK293 cells. Journal of Neuroscience Methods. 113: 207-14. PMID 11772442 DOI: 10.1016/S0165-0270(01)00500-3  1
2001 Groot-Kormelink PJ, Boorman JP, Sivilotti LG. Formation of functional alpha3beta4alpha5 human neuronal nicotinic receptors in Xenopus oocytes: a reporter mutation approach. British Journal of Pharmacology. 134: 789-96. PMID 11606319 DOI: 10.1038/sj.bjp.0704313  1
2001 Sivilotti L. Nicotinic receptors: Molecular issues Psycoloquy. 12: 1-9.  1
2001 Groot-Kormelink PJ, Boorman JP, Sivilotti LG. Formation of functional α3β4α5 human neuronal nicotinic receptors in Xenopus oocytes: A reporter mutation approach British Journal of Pharmacology. 134: 789-796.  1
2000 Boorman JP, Groot-Kormelink PJ, Sivilotti LG. Stoichiometry of human recombinant neuronal nicotinic receptors containing the b3 subunit expressed in Xenopus oocytes. The Journal of Physiology. 529: 565-77. PMID 11118490 DOI: 10.1111/j.1469-7793.2000.00565.x  1
1999 Boorman JP, Groot-Kormelink PJ, Sivilotti LG. A reporter mutation approach to study neuronal nicotinic acetylcholine receptors containing the human β3 subunit Journal of Pharmacy and Pharmacology. 51: 168.  1
1998 Groot-Kormelink PJ, Luyten WH, Colquhoun D, Sivilotti LG. A reporter mutation approach shows incorporation of the "orphan" subunit beta3 into a functional nicotinic receptor. The Journal of Biological Chemistry. 273: 15317-20. PMID 9624109 DOI: 10.1074/jbc.273.25.15317  1
1998 Lewis TM, Sivilotti LG, Colquhoun D, Gardiner RM, Schoepfer R, Rees M. Properties of human glycine receptors containing the hyperekplexia mutation alpha1(K276E), expressed in Xenopus oocytes. The Journal of Physiology. 507: 25-40. PMID 9490812 DOI: 10.1111/j.1469-7793.1998.025bu.x  1
1997 Lewis TM, Harkness PC, Sivilotti LG, Colquhoun D, Millar NS. The ion channel properties of a rat recombinant neuronal nicotinic receptor are dependent on the host cell type. The Journal of Physiology. 505: 299-306. PMID 9423173 DOI: 10.1111/j.1469-7793.1997.299bb.x  1
1997 Sivilotti L, Okuse K, Akopian AN, Moss S, Wood JN. A single serine residue confers tetrodotoxin insensitivity on the rat sensory-neuron-specific sodium channel SNS. Febs Letters. 409: 49-52. PMID 9199502 DOI: 10.1016/S0014-5793(97)00479-1  1
1997 Sivilotti LG, McNeil DK, Lewis TM, Nassar MA, Schoepfer R, Colquhoun D. Recombinant nicotinic receptors, expressed in Xenopus oocytes, do not resemble native rat sympathetic ganglion receptors in single-channel behaviour. The Journal of Physiology. 500: 123-38. PMID 9097938  1
1997 Akopian AN, Souslova V, Sivilotti L, Wood JN. Structure and distribution of a broadly expressed atypical sodium channel. Febs Letters. 400: 183-7. PMID 9001394 DOI: 10.1016/S0014-5793(96)01389-0  1
1996 Akopian AN, Sivilotti L, Wood JN. A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons. Nature. 379: 257-62. PMID 8538791 DOI: 10.1038/379257a0  1
1995 Sivilotti LG, Gerber G, Rawat B, Woolf CJ. Morphine selectively depresses the slowest, NMDA-independent component of C-fibre-evoked synaptic activity in the rat spinal cord in vitro. The European Journal of Neuroscience. 7: 12-8. PMID 7711929 DOI: 10.1111/j.1460-9568.1995.tb01015.x  1
1995 Sivilotti L, Colquhoun D. Acetylcholine receptors: too many channels, too few functions. Science (New York, N.Y.). 269: 1681-2. PMID 7569892  1
1995 Chen CC, Akopian AN, Sivilotti L, Colquhoun D, Burnstock G, Wood JN. A P2X purinoceptor expressed by a subset of sensory neurons. Nature. 377: 428-31. PMID 7566119 DOI: 10.1038/377428a0  1
1994 Sivilotti L, Woolf CJ. The contribution of GABAA and glycine receptors to central sensitization: disinhibition and touch-evoked allodynia in the spinal cord. Journal of Neurophysiology. 72: 169-79. PMID 7965003  1
1994 Covernton PJ, Kojima H, Sivilotti LG, Gibb AJ, Colquhoun D. Comparison of neuronal nicotinic receptors in rat sympathetic neurones with subunit pairs expressed in Xenopus oocytes. The Journal of Physiology. 481: 27-34. PMID 7853248  1
1994 Woolf CJ, Shortland P, Sivilotti LG. Sensitization of high mechanothreshold superficial dorsal horn and flexor motor neurones following chemosensitive primary afferent activation. Pain. 58: 141-55. PMID 7816483 DOI: 10.1016/0304-3959(94)90195-3  1
1993 Sivilotti LG, Thompson SW, Woolf CJ. Rate of rise of the cumulative depolarization evoked by repetitive stimulation of small-caliber afferents is a predictor of action potential windup in rat spinal neurons in vitro. Journal of Neurophysiology. 69: 1621-31. PMID 8389833  1
1993 Thompson SW, Woolf CJ, Sivilotti LG. Small-caliber afferent inputs produce a heterosynaptic facilitation of the synaptic responses evoked by primary afferent A-fibers in the neonatal rat spinal cord in vitro. Journal of Neurophysiology. 69: 2116-28. PMID 8350135  1
1992 Thompson SW, Gerber G, Sivilotti LG, Woolf CJ. Long duration ventral root potentials in the neonatal rat spinal cord in vitro; the effects of ionotropic and metabotropic excitatory amino acid receptor antagonists. Brain Research. 595: 87-97. PMID 1361412 DOI: 10.1016/0006-8993(92)91456-O  1
1992 Sivilotti L, Nistri A. An intracellular study of the effects of GABA on frog tectal neurones in vitro. Neuroscience Letters. 145: 28-32. PMID 1334242 DOI: 10.1016/0304-3940(92)90195-D  1
1991 Sivilotti L, Nistri A. GABA receptor mechanisms in the central nervous system. Progress in Neurobiology. 36: 35-92. PMID 1847747 DOI: 10.1016/0301-0082(91)90036-Z  1
1990 Mazda GY, Nistri A, Sivilotti L. The effect of GABA on the frog optic tectum is sensitive to ammonium and to penicillin. European Journal of Pharmacology. 179: 111-8. PMID 2163848 DOI: 10.1016/0014-2999(90)90408-X  1
1990 Nistri A, Sivilotti L, Welsh DM. An electrophysiological study of the action of N-methyl-D-aspartate on excitatory synaptic transmission in the optic tectum of the frog in vitro. Neuropharmacology. 29: 681-7. PMID 1974714 DOI: 10.1016/0028-3908(90)90030-U  1
1989 Sivilotti L, Nistri A. Antagonism of the actions of glutamate by pentobarbitone or midazolam in the frog optic tectum in vitro. Neuropharmacology. 28: 1107-12. PMID 2812283 DOI: 10.1016/0028-3908(89)90124-X  1
1989 Sivilotti L, Nistri A. Pharmacology of a novel effect of gamma-aminobutyric acid on the frog optic tectum in vitro. European Journal of Pharmacology. 164: 205-12. PMID 2788096 DOI: 10.1016/0014-2999(89)90460-3  1
1988 Sivilotti L. Nipecotic acid enhances synaptic transmission in the frog optic tectum by an action independent of GABA uptake inhibition. Neuroscience Letters. 88: 107-12. PMID 2840608 DOI: 10.1016/0304-3940(88)90323-0  1
1988 Sivilotti L, Nistri A. Complex effects of baclofen on synaptic transmission of the frog optic tectum in vitro. Neuroscience Letters. 85: 249-54. PMID 2836762 DOI: 10.1016/0304-3940(88)90360-6  1
1986 Sivilotti L, Nistri A. Biphasic effects of glycine on synaptic responses of the frog optic tectum in vitro. Neuroscience Letters. 66: 25-30. PMID 2872632 DOI: 10.1016/0304-3940(86)90160-6  1
1985 Beani L, Bianchi C, Nilsson L, Nordberg A, Romanelli L, Sivilotti L. The effect of nicotine and cytisine on 3H-acetylcholine release from cortical slices of guinea-pig brain. Naunyn-Schmiedeberg's Archives of Pharmacology. 331: 293-6. PMID 4088325 DOI: 10.1007/BF00634252  1
1985 Nistri A, Sivilotti L. An unusual effect of gamma-aminobutyric acid on synaptic transmission of frog tectal neurones in vitro. British Journal of Pharmacology. 85: 917-21. PMID 2994789  1
1985 Corradetti R, King AE, Nistri A, Rovira C, Sivilotti L. Pharmacological characterization of D-aminophosphonovaleric acid antagonism of amino acid and synaptically evoked excitations on frog motoneurones in vitro: an intracellular study. British Journal of Pharmacology. 86: 19-25. PMID 2864968 DOI: 10.1111/j.1476-5381.1985.tb09430.x  1
1984 Beani L, Bianchi C, Siniscalchi A, Sivilotti L, Tanganelli S, Veratti E. Different approaches to study acetylcholine release: endogenous ACh versus tritium efflux. Naunyn-Schmiedeberg's Archives of Pharmacology. 328: 119-26. PMID 6527702 DOI: 10.1007/BF00512060  1
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