Jeffrey D. Rothstein - Publications

Affiliations: 
Johns Hopkins University, Baltimore, MD 
Area:
Transporter, ALS

166 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Baxi EG, Thompson T, Li J, Kaye JA, Lim RG, Wu J, Ramamoorthy D, Lima L, Vaibhav V, Matlock A, Frank A, Coyne AN, Landin B, Ornelas L, Mosmiller E, ... ... Rothstein JD, et al. Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines. Nature Neuroscience. 25: 226-237. PMID 35115730 DOI: 10.1038/s41593-021-01006-0  0.568
2021 Johnson JO, Chia R, Miller DE, Li R, Kumaran R, Abramzon Y, Alahmady N, Renton AE, Topp SD, Gibbs JR, Cookson MR, Sabir MS, Dalgard CL, Troakes C, Jones AR, ... ... Rothstein JD, et al. Association of Variants in the SPTLC1 Gene With Juvenile Amyotrophic Lateral Sclerosis. Jama Neurology. PMID 34459874 DOI: 10.1001/jamaneurol.2021.2598  0.542
2020 Coyne AN, Zaepfel BL, Hayes L, Fitchman B, Salzberg Y, Luo EC, Bowen K, Trost H, Aigner S, Rigo F, Yeo GW, Harel A, Svendsen CN, Sareen D, Rothstein JD. GC Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD. Neuron. PMID 32673563 DOI: 10.1016/J.Neuron.2020.06.027  0.393
2020 Andrews JA, Berry JD, Baloh RH, Carberry N, Cudkowicz ME, Dedi B, Glass J, Maragakis NJ, Miller TM, Paganoni S, Rothstein JD, Shefner JM, Simmons Z, Weiss MD, Bedlack RS. Amyotrophic Lateral Sclerosis Care and Research in the USA During the COVID-19 Pandemic: Challenges and Opportunities. Muscle & Nerve. PMID 32445195 DOI: 10.1002/Mus.26989  0.57
2019 Agurto C, Ahmad O, Cecchi GA, Norel R, Pietrowicz M, Eyigoz EK, Mosmiller E, Baxi E, Rothstein JD, Roy P, Berry J, Maragakis NJ. Analyzing progression of motor and speech impairment in ALS. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2019: 6097-6102. PMID 31947236 DOI: 10.1109/EMBC.2019.8857300  0.563
2019 Cheng W, Wang S, Zhang Z, Morgens DW, Hayes LR, Lee S, Portz B, Xie Y, Nguyen BV, Haney MS, Yan S, Dong D, Coyne AN, Yang J, Xian F, ... ... Rothstein JD, et al. CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation. Neuron. PMID 31587919 DOI: 10.1016/J.Neuron.2019.09.003  0.315
2019 Katt ME, Mayo LN, Ellis SE, Mahairaki V, Rothstein JD, Cheng L, Searson PC. The role of mutations associated with familial neurodegenerative disorders on blood-brain barrier function in an iPSC model. Fluids and Barriers of the Cns. 16: 20. PMID 31303172 DOI: 10.1186/S12987-019-0139-4  0.309
2019 Savchenko E, Teku GN, Boza-Serrano A, Russ K, Berns M, Deierborg T, Lamas NJ, Wichterle H, Rothstein J, Henderson CE, Vihinen M, Roybon L. FGF family members differentially regulate maturation and proliferation of stem cell-derived astrocytes. Scientific Reports. 9: 9610. PMID 31270389 DOI: 10.1038/S41598-019-46110-1  0.35
2019 Miller SJ, Philips T, Kim N, Dastgheyb R, Chen Z, Hsieh YC, Daigle JG, Datta M, Chew J, Vidensky S, Pham JT, Hughes EG, Robinson MB, Sattler R, Tomer R, ... ... Rothstein JD, et al. Molecularly defined cortical astroglia subpopulation modulates neurons via secretion of Norrin. Nature Neuroscience. PMID 30936556 DOI: 10.1038/S41593-019-0366-7  0.349
2018 Miller SJ, Glatzer JC, Hsieh YC, Rothstein JD. Cortical astroglia undergo transcriptomic dysregulation in the G93A SOD1 ALS mouse model. Journal of Neurogenetics. 1-14. PMID 30398075 DOI: 10.1080/01677063.2018.1513508  0.395
2018 Hoye ML, Regan MR, Jensen LA, Lake AM, Reddy LV, Vidensky S, Richard JP, Maragakis NJ, Rothstein JD, Dougherty JD, Miller TM. Motor neuron-derived microRNAs cause astrocyte dysfunction in amyotrophic lateral sclerosis. Brain : a Journal of Neurology. PMID 30007309 DOI: 10.1093/Brain/Awy182  0.606
2018 Perkins EM, Clarkson YL, Suminaite D, Lyndon AR, Tanaka K, Rothstein JD, Skehel P, Wyllie DJA, Jackson M. Loss of cerebellar glutamate transporters EAAT4 and GLAST differentially affects the spontaneous firing pattern and survival of Purkinje cells. Human Molecular Genetics. PMID 29741614 DOI: 10.1093/hmg/ddy169  0.385
2018 Zhang K, Daigle JG, Cunningham KM, Coyne AN, Ruan K, Grima JC, Bowen KE, Wadhwa H, Yang P, Rigo F, Taylor JP, Gitler AD, Rothstein JD, Lloyd TE. Stress Granule Assembly Disrupts Nucleocytoplasmic Transport. Cell. PMID 29628143 DOI: 10.1016/J.Cell.2018.03.025  0.337
2018 Nicolas A, Kenna KP, Renton AE, Ticozzi N, Faghri F, Chia R, Dominov JA, Kenna BJ, Nalls MA, Keagle P, Rivera AM, van Rheenen W, Murphy NA, van Vugt JJFA, Geiger JT, ... ... Rothstein JD, et al. Genome-wide Analyses Identify KIF5A as a Novel ALS Gene. Neuron. 97: 1268-1283.e6. PMID 29566793 DOI: 10.1016/J.Neuron.2018.02.027  0.558
2017 Zhang K, Rothstein JD. Neurodegenerative disease: Two-for-one on potential therapies. Nature. PMID 28405020 DOI: 10.1038/Nature21911  0.373
2017 Grima JC, Daigle JG, Arbez N, Cunningham KC, Zhang K, Ochaba J, Geater C, Morozko E, Stocksdale J, Glatzer JC, Pham JT, Ahmed I, Peng Q, Wadhwa H, Pletnikova O, ... ... Rothstein JD, et al. Mutant Huntingtin Disrupts the Nuclear Pore Complex. Neuron. 94: 93-107.e6. PMID 28384479 DOI: 10.1016/J.Neuron.2017.03.023  0.362
2017 Gendron TF, Chew J, Stankowski JN, Hayes LR, Zhang YJ, Prudencio M, Carlomagno Y, Daughrity LM, Jansen-West K, Perkerson EA, O'Raw A, Cook C, Pregent L, Belzil V, van Blitterswijk M, ... ... Rothstein JD, et al. Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis. Science Translational Medicine. 9. PMID 28356511 DOI: 10.1126/Scitranslmed.Aai7866  0.318
2017 Peschansky V, Bedlack R, Quinn C, Karam C, Sherman A, Ostrow L, Hardiman O, Heiman-Patterson T, Gutmann L, Bromberg M, Carter G, Kabashi E, Bertorini T, Mozaffar T, Andersen P, ... ... Rothstein J, et al. ALSUntangled 38: L-serine Amyotrophic Lateral Sclerosis. 18: 148-151. PMID 27894192 DOI: 10.1080/21678421.2016.1250353  0.533
2017 Bedlack R, Fixsen E, Quinn C, Karam C, Sherman A, Ostrow L, Hardiman O, Heiman-Patterson T, Gutmann L, Bromberg M, Carter G, Kabashi E, Bertorini T, Mozaffar T, Andersen P, ... ... Rothstein J, et al. ALSUntangled No. 36: Accilion Amyotrophic Lateral Sclerosis. 18: 142-147. PMID 27685025 DOI: 10.1080/21678421.2016.1215400  0.572
2016 Perkins EM, Suminaite D, Clarkson YL, Lee SK, Lyndon AR, Rothstein JD, Wyllie DJ, Tanaka K, Jackson M. Posterior cerebellar Purkinje cells in an SCA5/SPARCA1 mouse model are especially vulnerable to the synergistic effect of loss of β-III spectrin and GLAST. Human Molecular Genetics. 25: 4448-4461. PMID 28173092 DOI: 10.1093/hmg/ddw274  0.318
2016 Le NT, Chang L, Kovlyagina I, Georgiou P, Safren N, Braunstein KE, Kvarta MD, Van Dyke AM, LeGates TA, Philips T, Morrison BM, Thompson SM, Puche AC, Gould TD, Rothstein JD, et al. Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS-FTD-linked UBQLN2 mutations. Proceedings of the National Academy of Sciences of the United States of America. PMID 27834214 DOI: 10.1073/Pnas.1608432113  0.399
2016 Ehmsen JT, Liu Y, Wang Y, Paladugu N, Johnson AE, Rothstein JD, du Lac S, Mattson MP, Höke A. The astrocytic transporter SLC7A10 (Asc-1) mediates glycinergic inhibition of spinal cord motor neurons. Scientific Reports. 6: 35592. PMID 27759100 DOI: 10.1038/Srep35592  0.386
2016 Miller SJ, Rothstein JD. Astroglia in Thick Tissue with Super Resolution and Cellular Reconstruction. Plos One. 11: e0160391. PMID 27494718 DOI: 10.1371/journal.pone.0160391  0.315
2016 Choi IY, Lim H, Estrellas K, Mula J, Cohen TV, Zhang Y, Donnelly CJ, Richard JP, Kim YJ, Kim H, Kazuki Y, Oshimura M, Li HL, Hotta A, Rothstein J, et al. Concordant but Varied Phenotypes among Duchenne Muscular Dystrophy Patient-Specific Myoblasts Derived using a Human iPSC-Based Model. Cell Reports. PMID 27239027 DOI: 10.1016/J.Celrep.2016.05.016  0.58
2016 Fixsen E, Bedlack R, Quinn C, Karam C, Sherman A, Ostrow L, Hardiman O, Heiman-Patterson T, Gutmann L, Bromberg M, Carter G, Kabashi E, Bertorini T, Mozaffar T, Andersen P, ... ... Rothstein J, et al. ALSUntangled No. 35: Hyperbaric Oxygen Therapy* Amyotrophic Lateral Sclerosis. 17: 622-624. PMID 27089115 DOI: 10.3109/21678421.2016.1172818  0.531
2016 Bedlack R, Quinn C, Karam C, Sherman A, Ostrow L, Hardiman O, Heiman-Patterson T, Gutmann L, Bromberg M, Carter G, Kabashi E, Bertorini T, Mozaffar T, Andersen P, Dietz J, ... ... Rothstein J, et al. ALSUntangled No. 34: GM604 Amyotrophic Lateral Sclerosis. 17: 617-621. PMID 27043278 DOI: 10.3109/21678421.2016.1164940  0.534
2016 Zhang YJ, Gendron TF, Grima JC, Sasaguri H, Jansen-West K, Xu YF, Katzman RB, Gass J, Murray ME, Shinohara M, Lin WL, Garrett A, Stankowski JN, Daughrity L, Tong J, ... ... Rothstein JD, et al. C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins. Nature Neuroscience. PMID 26998601 DOI: 10.1038/Nn.4272  0.305
2015 Ghosh M, Lane M, Krizman E, Sattler R, Rothstein JD, Robinson MB. Transcription Factor Pax6 Contributes to Induction of GLT-1 Expression in Astrocytes Through an Interaction with a Distal Enhancer Element. Journal of Neurochemistry. PMID 26485579 DOI: 10.1111/Jnc.13406  0.37
2015 Li W, Lee MH, Henderson L, Tyagi R, Bachani M, Steiner J, Campanac E, Hoffman DA, von Geldern G, Johnson K, Maric D, Morris HD, Lentz M, Pak K, Mammen A, ... ... Rothstein J, et al. Human endogenous retrovirus-K contributes to motor neuron disease. Science Translational Medicine. 7: 307ra153. PMID 26424568 DOI: 10.1126/Scitranslmed.Aac8201  0.384
2015 Zhang K, Donnelly CJ, Haeusler AR, Grima JC, Machamer JB, Steinwald P, Daley EL, Miller SJ, Cunningham KM, Vidensky S, Gupta S, Thomas MA, Hong I, Chiu SL, Huganir RL, ... ... Rothstein JD, et al. The C9orf72 repeat expansion disrupts nucleocytoplasmic transport. Nature. 525: 56-61. PMID 26308891 DOI: 10.1038/Nature14973  0.392
2015 Zhang PW, Haidet-Phillips AM, Pham JT, Lee Y, Huo Y, Tienari PJ, Maragakis NJ, Sattler R, Rothstein JD. Generation of GFAP::GFP astrocyte reporter lines from human adult fibroblast-derived iPS cells using zinc-finger nuclease technology. Glia. PMID 26295203 DOI: 10.1002/Glia.22903  0.572
2015 Li Y, Balasubramanian U, Cohen D, Zhang PW, Mosmiller E, Sattler R, Maragakis NJ, Rothstein JD. A comprehensive library of familial human amyotrophic lateral sclerosis induced pluripotent stem cells. Plos One. 10: e0118266. PMID 25760436 DOI: 10.1371/Journal.Pone.0118266  0.62
2015 Bedlack R, Quinn C, Karam C, Sherman A, Ostrow L, Hardiman O, Heiman-Patterson T, Gutmann L, Bromberg M, Carter G, Kabashi E, Bertorini T, Mozaffar T, Andersen P, Dietz J, ... ... Rothstein J, et al. ALSUntangled No. 29: MitoQ Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 16: 427-429. DOI: 10.3109/21678421.2015.1050897  0.529
2015 Bedlack R, Quinn C, Karam C, Sherman A, Ostrow L, Hardiman O, Heiman-Patterson T, Gutmann L, Bromberg M, Carter G, Kabashi E, Bertorini T, Mozaffar T, Andersen P, Dietz J, ... ... Rothstein J, et al. ALSUntangled: Introducing the table of evidence Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 16: 142-145. DOI: 10.3109/21678421.2014.987476  0.54
2014 Al-Sarraj S, King A, Cleveland M, Pradat PF, Corse A, Rothstein JD, Leigh PN, Abila B, Bates S, Wurthner J, Meininger V. Mitochondrial abnormalities and low grade inflammation are present in the skeletal muscle of a minority of patients with amyotrophic lateral sclerosis; an observational myopathology study. Acta Neuropathologica Communications. 2: 165. PMID 25510661 DOI: 10.1186/s40478-014-0165-z  0.367
2014 Cudkowicz ME, Titus S, Kearney M, Yu H, Sherman A, Schoenfeld D, Hayden D, Shui A, Brooks B, Conwit R, Felsenstein D, Greenblatt DJ, Keroack M, Kissel JT, Miller R, ... ... Rothstein JD, et al. Safety and efficacy of ceftriaxone for amyotrophic lateral sclerosis: a multi-stage, randomised, double-blind, placebo-controlled trial. The Lancet. Neurology. 13: 1083-91. PMID 25297012 DOI: 10.1016/S1474-4422(14)70222-4  0.31
2014 Johnson JO, Pioro EP, Boehringer A, Chia R, Feit H, Renton AE, Pliner HA, Abramzon Y, Marangi G, Winborn BJ, Gibbs JR, Nalls MA, Morgan S, Shoai M, Hardy J, ... ... Rothstein JD, et al. Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis. Nature Neuroscience. 17: 664-6. PMID 24686783 DOI: 10.1038/Nn.3688  0.357
2014 Haeusler AR, Donnelly CJ, Periz G, Simko EA, Shaw PG, Kim MS, Maragakis NJ, Troncoso JC, Pandey A, Sattler R, Rothstein JD, Wang J. C9orf72 nucleotide repeat structures initiate molecular cascades of disease. Nature. 507: 195-200. PMID 24598541 DOI: 10.1038/Nature13124  0.589
2014 Butovsky O, Jedrychowski MP, Moore CS, Cialic R, Lanser AJ, Gabriely G, Koeglsperger T, Dake B, Wu PM, Doykan CE, Fanek Z, Liu L, Chen Z, Rothstein JD, Ransohoff RM, et al. Identification of a unique TGF-β-dependent molecular and functional signature in microglia. Nature Neuroscience. 17: 131-43. PMID 24316888 DOI: 10.1038/Nn.3599  0.324
2014 Bedlack R, Quinn C, Karam C, Sherman A, Ostrow L, Hardiman O, Heiman-Patterson T, Gutmann L, Bromberg M, Carter G, Kabashi E, Bertorini T, Mozaffar T, Andersen P, Dietz J, ... ... Rothstein J, et al. ALSUntangled no. 26: Lunasin Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 15: 622-626. DOI: 10.3109/21678421.2014.959297  0.522
2013 Zu T, Liu Y, Bañez-Coronel M, Reid T, Pletnikova O, Lewis J, Miller TM, Harms MB, Falchook AE, Subramony SH, Ostrow LW, Rothstein JD, Troncoso JC, Ranum LP. RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia. Proceedings of the National Academy of Sciences of the United States of America. 110: E4968-77. PMID 24248382 DOI: 10.1073/Pnas.1315438110  0.352
2013 Donnelly CJ, Zhang PW, Pham JT, Haeusler AR, Heusler AR, Mistry NA, Vidensky S, Daley EL, Poth EM, Hoover B, Fines DM, Maragakis N, Tienari PJ, Petrucelli L, Traynor BJ, ... ... Rothstein JD, et al. RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention. Neuron. 80: 415-28. PMID 24139042 DOI: 10.1016/J.Neuron.2013.10.015  0.614
2013 Roybon L, Lamas NJ, Garcia-Diaz A, Yang EJ, Sattler R, Jackson-Lewis V, Kim YA, Kachel CA, Rothstein JD, Przedborski S, Wichterle H, Henderson CE. Human stem cell-derived spinal cord astrocytes with defined mature or reactive phenotypes. Cell Reports. 4: 1035-48. PMID 23994478 DOI: 10.1016/J.Celrep.2013.06.021  0.33
2013 Sattler R, Tyler B, Hoover B, Coddington LT, Recinos V, Hwang L, Brem H, Rothstein JD. Increased expression of glutamate transporter GLT-1 in peritumoral tissue associated with prolonged survival and decreases in tumor growth in a rat model of experimental malignant glioma. Journal of Neurosurgery. 119: 878-86. PMID 23909244 DOI: 10.3171/2013.6.Jns122319  0.374
2013 Ravits J, Appel S, Baloh RH, Barohn R, Brooks BR, Elman L, Floeter MK, Henderson C, Lomen-Hoerth C, Macklis JD, McCluskey L, Mitsumoto H, Przedborski S, Rothstein J, Trojanowski JQ, et al. Deciphering amyotrophic lateral sclerosis: what phenotype, neuropathology and genetics are telling us about pathogenesis. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 14: 5-18. PMID 23678876 DOI: 10.3109/21678421.2013.778548  0.383
2013 Fournier C, Bedlack B, Hardiman O, Heiman-Patterson T, Gutmann L, Bromberg M, Ostrow L, Carter G, Kabashi E, Bertorini T, Mozaffar T, Andersen P, Dietz J, Gamez J, ... ... Rothstein J, et al. ALS Untangled No. 20: the Deanna protocol. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 14: 319-23. PMID 23638638 DOI: 10.3109/21678421.2013.788405  0.575
2013 Kang SH, Li Y, Fukaya M, Lorenzini I, Cleveland DW, Ostrow LW, Rothstein JD, Bergles DE. Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis. Nature Neuroscience. 16: 571-9. PMID 23542689 DOI: 10.1038/Nn.3357  0.386
2013 Morel L, Regan M, Higashimori H, Ng SK, Esau C, Vidensky S, Rothstein J, Yang Y. Neuronal exosomal miRNA-dependent translational regulation of astroglial glutamate transporter GLT1. The Journal of Biological Chemistry. 288: 7105-16. PMID 23364798 DOI: 10.1074/Jbc.M112.410944  0.332
2013 Donnelly CJ, Zhang PW, Pham JT, Haeusler AR, Mistry NA, Vidensky S, Daley EL, Poth EM, Hoover B, Fines DM, Maragakis N, Tienari PJ, Petrucelli L, Traynor BJ, Wang J, ... ... Rothstein JD, et al. RNA Toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention [Neuron, 79, (September 18, 2013), 1222-1231] Neuron. 80: 1102. DOI: 10.1016/J.Neuron.2013.10.055  0.594
2012 Teng YD, Benn SC, Kalkanis SN, Shefner JM, Onario RC, Cheng B, Lachyankar MB, Marconi M, Li J, Yu D, Han I, Maragakis NJ, Lládo J, Erkmen K, Redmond DE, ... ... Rothstein JD, et al. Multimodal actions of neural stem cells in a mouse model of ALS: a meta-analysis. Science Translational Medicine. 4: 165ra164. PMID 23253611 DOI: 10.1126/Scitranslmed.3004579  0.631
2012 Lerman BJ, Hoffman EP, Sutherland ML, Bouri K, Hsu DK, Liu FT, Rothstein JD, Knoblach SM. Deletion of galectin-3 exacerbates microglial activation and accelerates disease progression and demise in a SOD1(G93A) mouse model of amyotrophic lateral sclerosis. Brain and Behavior. 2: 563-75. PMID 23139902 DOI: 10.1002/brb3.75  0.343
2012 Wray S, Self M, Lewis PA, Taanman JW, Ryan NS, Mahoney CJ, Liang Y, Devine MJ, Sheerin UM, Houlden H, Morris HR, Healy D, ... ... Rothstein JD, et al. Creation of an open-access, mutation-defined fibroblast resource for neurological disease research. Plos One. 7: e43099. PMID 22952635 DOI: 10.1371/Journal.Pone.0043099  0.589
2012 Lee Y, Morrison BM, Li Y, Lengacher S, Farah MH, Hoffman PN, Liu Y, Tsingalia A, Jin L, Zhang PW, Pellerin L, Magistretti PJ, Rothstein JD. Oligodendroglia metabolically support axons and contribute to neurodegeneration. Nature. 487: 443-8. PMID 22801498 DOI: 10.1038/Nature11314  0.328
2012 Phillips AW, Falahati S, DeSilva R, Shats I, Marx J, Arauz E, Kerr DA, Rothstein JD, Johnston MV, Fatemi A. Derivation of glial restricted precursors from E13 mice. Journal of Visualized Experiments : Jove. PMID 22760029 DOI: 10.3791/3462  0.507
2012 Brotherton TE, Li Y, Cooper D, Gearing M, Julien JP, Rothstein JD, Boylan K, Glass JD. Localization of a toxic form of superoxide dismutase 1 protein to pathologically affected tissues in familial ALS. Proceedings of the National Academy of Sciences of the United States of America. 109: 5505-10. PMID 22431618 DOI: 10.1073/Pnas.1115009109  0.384
2012 Benediktsson AM, Marrs GS, Tu JC, Worley PF, Rothstein JD, Bergles DE, Dailey ME. Neuronal activity regulates glutamate transporter dynamics in developing astrocytes. Glia. 60: 175-88. PMID 22052455 DOI: 10.1002/Glia.21249  0.355
2011 Sattler R, Ayukawa Y, Coddington L, Sawa A, Block D, Chipkin R, Rothstein JD. Human nasal olfactory epithelium as a dynamic marker for CNS therapy development. Experimental Neurology. 232: 203-11. PMID 21945230 DOI: 10.1016/J.Expneurol.2011.09.002  0.319
2011 Renton AE, Majounie E, Waite A, Simón-Sánchez J, Rollinson S, Gibbs JR, Schymick JC, Laaksovirta H, van Swieten JC, Myllykangas L, Kalimo H, Paetau A, Abramzon Y, Remes AM, Kaganovich A, ... ... Rothstein JD, et al. A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD. Neuron. 72: 257-68. PMID 21944779 DOI: 10.1016/J.Neuron.2011.09.010  0.308
2011 Lepore AC, O'Donnell J, Bonner JF, Paul C, Miller ME, Rauck B, Kushner RA, Rothstein JD, Fischer I, Maragakis NJ. Spatial and temporal changes in promoter activity of the astrocyte glutamate transporter GLT1 following traumatic spinal cord injury. Journal of Neuroscience Research. 89: 1001-17. PMID 21488085 DOI: 10.1002/Jnr.22624  0.62
2011 Douville R, Liu J, Rothstein J, Nath A. Identification of active loci of a human endogenous retrovirus in neurons of patients with amyotrophic lateral sclerosis. Annals of Neurology. 69: 141-51. PMID 21280084 DOI: 10.1002/Ana.22149  0.357
2011 Maragakis N, Rothstein JD. New treatments in amyotrophic lateral sclerosis. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 370-2. PMID 21116264 DOI: 10.1038/npp.2010.140  0.572
2011 Yang Y, Vidensky S, Jin L, Jie C, Lorenzini I, Frankl M, Rothstein JD. Molecular comparison of GLT1+ and ALDH1L1+ astrocytes in vivo in astroglial reporter mice. Glia. 59: 200-7. PMID 21046559 DOI: 10.1002/glia.21089  0.332
2011 Li Y, Sattler R, Yang EJ, Nunes A, Ayukawa Y, Akhtar S, Ji G, Zhang PW, Rothstein JD. Harmine, a natural beta-carboline alkaloid, upregulates astroglial glutamate transporter expression. Neuropharmacology. 60: 1168-75. PMID 21034752 DOI: 10.1016/J.Neuropharm.2010.10.016  0.377
2010 Johnson JO, Mandrioli J, Benatar M, Abramzon Y, Van Deerlin VM, Trojanowski JQ, Gibbs JR, Brunetti M, Gronka S, Wuu J, Ding J, McCluskey L, Martinez-Lage M, Falcone D, Hernandez DG, ... ... Rothstein J, et al. Exome sequencing reveals VCP mutations as a cause of familial ALS. Neuron. 68: 857-64. PMID 21145000 DOI: 10.1016/J.Neuron.2010.11.036  0.344
2010 Kang SH, Fukaya M, Yang JK, Rothstein JD, Bergles DE. NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration. Neuron. 68: 668-81. PMID 21092857 DOI: 10.1016/J.Neuron.2010.09.009  0.338
2010 Paukert M, Huang YH, Tanaka K, Rothstein JD, Bergles DE. Zones of enhanced glutamate release from climbing fibers in the mammalian cerebellum. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 7290-9. PMID 20505095 DOI: 10.1523/Jneurosci.5118-09.2010  0.309
2010 Perkins EM, Clarkson YL, Sabatier N, Longhurst DM, Millward CP, Jack J, Toraiwa J, Watanabe M, Rothstein JD, Lyndon AR, Wyllie DJ, Dutia MB, Jackson M. Loss of beta-III spectrin leads to Purkinje cell dysfunction recapitulating the behavior and neuropathology of spinocerebellar ataxia type 5 in humans. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 4857-67. PMID 20371805 DOI: 10.1523/JNEUROSCI.6065-09.2010  0.308
2010 de Vivo L, Melone M, Bucci G, Rothstein JD, Conti F. Quantitative analysis of EAAT4 promoter activity in neurons and astrocytes of mouse somatic sensory cortex. Neuroscience Letters. 474: 42-5. PMID 20211693 DOI: 10.1016/j.neulet.2010.03.003  0.329
2009 Klaus F, Gehring EM, Zürn A, Laufer J, Lindner R, Strutz-Seebohm N, Tavaré JM, Rothstein JD, Boehmer C, Palmada M, Gruner I, Lang UE, Seebohm G, Lang F. Regulation of the Na(+)-coupled glutamate transporter EAAT3 by PIKfyve. Neurochemistry International. 54: 372-7. PMID 19418632 DOI: 10.1016/J.Neuint.2009.01.002  0.334
2009 Carmen J, Rothstein JD, Kerr DA. Tumor necrosis factor-alpha modulates glutamate transport in the CNS and is a critical determinant of outcome from viral encephalomyelitis. Brain Research. 1263: 143-54. PMID 19368827 DOI: 10.1016/J.Brainres.2009.01.040  0.553
2009 Yang Y, Gozen O, Watkins A, Lorenzini I, Lepore A, Gao Y, Vidensky S, Brennan J, Poulsen D, Won Park J, Li Jeon N, Robinson MB, Rothstein JD. Presynaptic regulation of astroglial excitatory neurotransmitter transporter GLT1. Neuron. 61: 880-94. PMID 19323997 DOI: 10.1016/J.Neuron.2009.02.010  0.386
2009 Maier S, Reiterer V, Ruggiero AM, Rothstein JD, Thomas S, Dahm R, Sitte HH, Farhan H. GTRAP3-18 serves as a negative regulator of Rab1 in protein transport and neuronal differentiation. Journal of Cellular and Molecular Medicine. 13: 114-24. PMID 18363836 DOI: 10.1111/J.1582-4934.2008.00303.X  0.74
2008 Lepore AC, Rauck B, Dejea C, Pardo AC, Rao MS, Rothstein JD, Maragakis NJ. Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease. Nature Neuroscience. 11: 1294-301. PMID 18931666 DOI: 10.1038/Nn.2210  0.653
2008 Chang Y, Kong Q, Shan X, Tian G, Ilieva H, Cleveland DW, Rothstein JD, Borchelt DR, Wong PC, Lin CL. Messenger RNA oxidation occurs early in disease pathogenesis and promotes motor neuron degeneration in ALS. Plos One. 3: e2849. PMID 18682740 DOI: 10.1371/Journal.Pone.0002849  0.354
2008 Laird FM, Farah MH, Ackerley S, Hoke A, Maragakis N, Rothstein JD, Griffin J, Price DL, Martin LJ, Wong PC. Motor neuron disease occurring in a mutant dynactin mouse model is characterized by defects in vesicular trafficking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 1997-2005. PMID 18305234 DOI: 10.1523/Jneurosci.4231-07.2008  0.643
2008 Ruggiero AM, Liu Y, Vidensky S, Maier S, Jung E, Farhan H, Robinson MB, Sitte HH, Rothstein JD. The endoplasmic reticulum exit of glutamate transporter is regulated by the inducible mammalian Yip6b/GTRAP3-18 protein. The Journal of Biological Chemistry. 283: 6175-83. PMID 18167356 DOI: 10.1074/Jbc.M701008200  0.723
2008 Liu Y, Vidensky S, Ruggiero AM, Maier S, Sitte HH, Rothstein JD. Reticulon RTN2B regulates trafficking and function of neuronal glutamate transporter EAAC1. The Journal of Biological Chemistry. 283: 6561-71. PMID 18096700 DOI: 10.1074/Jbc.M708096200  0.74
2007 Lepore AC, Haenggeli C, Gasmi M, Bishop KM, Bartus RT, Maragakis NJ, Rothstein JD. Intraparenchymal spinal cord delivery of adeno-associated virus IGF-1 is protective in the SOD1G93A model of ALS. Brain Research. 1185: 256-65. PMID 17963733 DOI: 10.1016/J.Brainres.2007.09.034  0.615
2007 Regan MR, Huang YH, Kim YS, Dykes-Hoberg MI, Jin L, Watkins AM, Bergles DE, Rothstein JD. Variations in promoter activity reveal a differential expression and physiology of glutamate transporters by glia in the developing and mature CNS. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 6607-19. PMID 17581948 DOI: 10.1523/Jneurosci.0790-07.2007  0.374
2007 Rumbaugh JA, Li G, Rothstein J, Nath A. Ceftriaxone protects against the neurotoxicity of human immunodeficiency virus proteins Journal of Neurovirology. 13: 168-172. PMID 17505985 DOI: 10.1080/13550280601178218  0.335
2007 Schymick JC, Yang Y, Andersen PM, Vonsattel JP, Greenway M, Momeni P, Elder J, Chiò A, Restagno G, Robberecht W, Dahlberg C, Mukherjee O, Goate A, Graff-Radford N, Caselli RJ, ... ... Rothstein J, et al. Progranulin mutations and amyotrophic lateral sclerosis or amyotrophic lateral sclerosis-frontotemporal dementia phenotypes. Journal of Neurology, Neurosurgery, and Psychiatry. 78: 754-6. PMID 17371905 DOI: 10.1136/Jnnp.2006.109553  0.31
2007 Haenggeli C, Julien JP, Mosley RL, Perez N, Dhar A, Gendelman HE, Rothstein JD. Therapeutic immunization with a glatiramer acetate derivative does not alter survival in G93A and G37R SOD1 mouse models of familial ALS. Neurobiology of Disease. 26: 146-52. PMID 17276077 DOI: 10.1016/J.Nbd.2006.12.013  0.329
2007 Gincel D, Regan MR, Jin L, Watkins AM, Bergles DE, Rothstein JD. Analysis of cerebellar Purkinje cells using EAAT4 glutamate transporter promoter reporter in mice generated via bacterial artificial chromosome-mediated transgenesis. Experimental Neurology. 203: 205-12. PMID 17022974 DOI: 10.1016/j.expneurol.2006.08.016  0.369
2007 Maragakis NJ, Rothstein JD. Motor Neuron Disease: Amyotrophic Lateral Sclerosis Molecular Neurology. 307-319. DOI: 10.1016/B978-012369509-3.50022-6  0.529
2007 Maragakis NJ, Rothstein JD. Amyotrophic lateral sclerosis: Idiopathic and inherited Neurobiology of Disease. 521-535. DOI: 10.1016/B978-012088592-3/50048-7  0.572
2006 Maragakis NJ, Rothstein JD. Mechanisms of Disease: astrocytes in neurodegenerative disease. Nature Clinical Practice. Neurology. 2: 679-89. PMID 17117171 DOI: 10.1038/ncpneuro0355  0.572
2006 Lai C, Xie C, McCormack SG, Chiang HC, Michalak MK, Lin X, Chandran J, Shim H, Shimoji M, Cookson MR, Huganir RL, Rothstein JD, Price DL, Wong PC, Martin LJ, et al. Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 11798-806. PMID 17093100 DOI: 10.1523/Jneurosci.2084-06.2006  0.4
2006 Autry AE, Grillo CA, Piroli GG, Rothstein JD, McEwen BS, Reagan LP. Glucocorticoid regulation of GLT-1 glutamate transporter isoform expression in the rat hippocampus. Neuroendocrinology. 83: 371-9. PMID 17028421 DOI: 10.1159/000096092  0.303
2006 Deshpande DM, Kim YS, Martinez T, Carmen J, Dike S, Shats I, Rubin LL, Drummond J, Krishnan C, Hoke A, Maragakis N, Shefner J, Rothstein JD, Kerr DA. Recovery from paralysis in adult rats using embryonic stem cells. Annals of Neurology. 60: 32-44. PMID 16802299 DOI: 10.1002/Ana.20901  0.671
2006 Cudkowicz ME, Shefner JM, Schoenfeld DA, Zhang H, Andreasson KI, Rothstein JD, Drachman DB. Trial of celecoxib in amyotrophic lateral sclerosis. Annals of Neurology. 60: 22-31. PMID 16802291 DOI: 10.1002/Ana.20903  0.307
2006 Pardo AC, Wong V, Benson LM, Dykes M, Tanaka K, Rothstein JD, Maragakis NJ. Loss of the astrocyte glutamate transporter GLT1 modifies disease in SOD1(G93A) mice. Experimental Neurology. 201: 120-30. PMID 16753145 DOI: 10.1016/j.expneurol.2006.03.028  0.655
2006 Li LB, Toan SV, Zelenaia O, Watson DJ, Wolfe JH, Rothstein JD, Robinson MB. Regulation of astrocytic glutamate transporter expression by Akt: evidence for a selective transcriptional effect on the GLT-1/EAAT2 subtype. Journal of Neurochemistry. 97: 759-71. PMID 16573655 DOI: 10.1111/J.1471-4159.2006.03743.X  0.331
2006 Ikeda Y, Dick KA, Weatherspoon MR, Gincel D, Armbrust KR, Dalton JC, Stevanin G, Dürr A, Zühlke C, Bürk K, Clark HB, Brice A, Rothstein JD, Schut LJ, Day JW, et al. Spectrin mutations cause spinocerebellar ataxia type 5. Nature Genetics. 38: 184-90. PMID 16429157 DOI: 10.1038/Ng1728  0.302
2006 Ganel R, Ho T, Maragakis NJ, Jackson M, Steiner JP, Rothstein JD. Selective up-regulation of the glial Na+-dependent glutamate transporter GLT1 by a neuroimmunophilin ligand results in neuroprotection. Neurobiology of Disease. 21: 556-67. PMID 16274998 DOI: 10.1016/j.nbd.2005.08.014  0.655
2006 Lladó J, Haenggeli C, Pardo A, Wong V, Benson L, Coccia C, Rothstein JD, Shefner JM, Maragakis NJ. Degeneration of respiratory motor neurons in the SOD1 G93A transgenic rat model of ALS. Neurobiology of Disease. 21: 110-8. PMID 16084734 DOI: 10.1016/j.nbd.2005.06.019  0.625
2005 Maragakis NJ, Rao MS, Llado J, Wong V, Xue H, Pardo A, Herring J, Kerr D, Coccia C, Rothstein JD. Glial restricted precursors protect against chronic glutamate neurotoxicity of motor neurons in vitro. Glia. 50: 145-59. PMID 15657939 DOI: 10.1002/glia.20161  0.707
2005 Rothstein JD, Patel S, Regan MR, Haenggeli C, Huang YH, Bergles DE, Jin L, Dykes Hoberg M, Vidensky S, Chung DS, Toan SV, Bruijn LI, Su ZZ, Gupta P, Fisher PB. Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Nature. 433: 73-7. PMID 15635412 DOI: 10.1038/Nature03180  0.388
2005 Haenggeli C, Kaspar B, Rothstein J. 652. Adeno-Associated Vector Delivery of Gutamate Transporters in an ALS Mouse Model Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.192  0.445
2004 Shefner JM, Cudkowicz ME, Schoenfeld D, Conrad T, Taft J, Chilton M, Urbinelli L, Qureshi M, Zhang H, Pestronk A, Caress J, Donofrio P, Sorenson E, Bradley W, Lomen-Hoerth C, ... ... Rothstein J, et al. A clinical trial of creatine in ALS. Neurology. 63: 1656-61. PMID 15534251 DOI: 10.1212/01.Wnl.0000142992.81995.F0  0.314
2004 Lladó J, Haenggeli C, Maragakis NJ, Snyder EY, Rothstein JD. Neural stem cells protect against glutamate-induced excitotoxicity and promote survival of injured motor neurons through the secretion of neurotrophic factors. Molecular and Cellular Neurosciences. 27: 322-31. PMID 15519246 DOI: 10.1016/j.mcn.2004.07.010  0.627
2004 Darman J, Backovic S, Dike S, Maragakis NJ, Krishnan C, Rothstein JD, Irani DN, Kerr DA. Viral-induced spinal motor neuron death is non-cell-autonomous and involves glutamate excitotoxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 7566-75. PMID 15329404 DOI: 10.1523/JNEUROSCI.2002-04.2004  0.701
2004 Harper JM, Krishnan C, Darman JS, Deshpande DM, Peck S, Shats I, Backovic S, Rothstein JD, Kerr DA. Axonal growth of embryonic stem cell-derived motoneurons in vitro and in motoneuron-injured adult rats. Proceedings of the National Academy of Sciences of the United States of America. 101: 7123-8. PMID 15118094 DOI: 10.1073/pnas.0401103101  0.494
2004 Schniepp R, Kohler K, Ladewig T, Guenther E, Henke G, Palmada M, Boehmer C, Rothstein JD, Bröer S, Lang F. Retinal colocalization and in vitro interaction of the glutamate transporter EAAT3 and the serum- and glucocorticoid-inducible kinase SGK1 [correction]. Investigative Ophthalmology & Visual Science. 45: 1442-9. PMID 15111600 DOI: 10.1167/Iovs.03-0062  0.354
2004 Maragakis NJ, Rothstein JD. Glutamate transporters: animal models to neurologic disease. Neurobiology of Disease. 15: 461-73. PMID 15056453 DOI: 10.1016/j.nbd.2003.12.007  0.572
2004 Nargi-Aizenman JL, Havert MB, Zhang M, Irani DN, Rothstein JD, Griffin DE. Glutamate receptor antagonists protect from virus-induced neural degeneration. Annals of Neurology. 55: 541-9. PMID 15048893 DOI: 10.1002/Ana.20033  0.345
2004 Maragakis NJ, Dykes-Hoberg M, Rothstein JD. Altered expression of the glutamate transporter EAAT2b in neurological disease. Annals of Neurology. 55: 469-77. PMID 15048885 DOI: 10.1002/ana.20003  0.572
2004 Reagan LP, Rosell DR, Wood GE, Spedding M, Muñoz C, Rothstein J, McEwen BS. Chronic restraint stress up-regulates GLT-1 mRNA and protein expression in the rat hippocampus: reversal by tianeptine. Proceedings of the National Academy of Sciences of the United States of America. 101: 2179-84. PMID 14766991 DOI: 10.1073/pnas.0307294101  0.313
2004 Maragakis NJ, Dietrich J, Wong V, Xue H, Mayer-Proschel M, Rao MS, Rothstein JD. Glutamate transporter expression and function in human glial progenitors. Glia. 45: 133-43. PMID 14730707 DOI: 10.1002/Glia.10310  0.639
2004 Huang YH, Dykes-Hoberg M, Tanaka K, Rothstein JD, Bergles DE. Climbing fiber activation of EAAT4 transporters and kainate receptors in cerebellar Purkinje cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 103-11. PMID 14715943 DOI: 10.1523/Jneurosci.4473-03.2004  0.319
2003 Boehmer C, Henke G, Schniepp R, Palmada M, Rothstein JD, Bröer S, Lang F. Regulation of the glutamate transporter EAAT1 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid-inducible kinase isoforms SGK1/3 and protein kinase B. Journal of Neurochemistry. 86: 1181-8. PMID 12911626 DOI: 10.1046/J.1471-4159.2003.01937.X  0.331
2003 Kaspar BK, Lladó J, Sherkat N, Rothstein JD, Gage FH. Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model. Science (New York, N.Y.). 301: 839-42. PMID 12907804 DOI: 10.1126/Science.1086137  0.379
2003 Wang Z, Pekarskaya O, Bencheikh M, Chao W, Gelbard HA, Ghorpade A, Rothstein JD, Volsky DJ. Reduced expression of glutamate transporter EAAT2 and impaired glutamate transport in human primary astrocytes exposed to HIV-1 or gp120. Virology. 312: 60-73. PMID 12890621 DOI: 10.1016/S0042-6822(03)00181-8  0.347
2003 Kerr DA, Lladó J, Shamblott MJ, Maragakis NJ, Irani DN, Crawford TO, Krishnan C, Dike S, Gearhart JD, Rothstein JD. Human embryonic germ cell derivatives facilitate motor recovery of rats with diffuse motor neuron injury. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 5131-40. PMID 12832537 DOI: 10.1523/Jneurosci.23-12-05131.2003  0.69
2003 Maragakis NJ, Jackson M, Ganel R, Rothstein JD. Topiramate protects against motor neuron degeneration in organotypic spinal cord cultures but not in G93A SOD1 transgenic mice. Neuroscience Letters. 338: 107-10. PMID 12566164 DOI: 10.1016/S0304-3940(02)01386-1  0.572
2002 Drachman DB, Frank K, Dykes-Hoberg M, Teismann P, Almer G, Przedborski S, Rothstein JD. Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS. Annals of Neurology. 52: 771-8. PMID 12447931 DOI: 10.1002/Ana.10374  0.385
2002 Cutler RG, Pedersen WA, Camandola S, Rothstein JD, Mattson MP. Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress-induced death of motor neurons in amyotrophic lateral sclerosis. Annals of Neurology. 52: 448-57. PMID 12325074 DOI: 10.1002/Ana.10312  0.366
2002 Sepkuty JP, Cohen AS, Eccles C, Rafiq A, Behar K, Ganel R, Coulter DA, Rothstein JD. A neuronal glutamate transporter contributes to neurotransmitter GABA synthesis and epilepsy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 6372-9. PMID 12151515 DOI: 10.1523/Jneurosci.22-15-06372.2002  0.314
2002 Subramaniam JR, Lyons WE, Liu J, Bartnikas TB, Rothstein J, Price DL, Cleveland DW, Gitlin JD, Wong PC. Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading. Nature Neuroscience. 5: 301-7. PMID 11889469 DOI: 10.1038/Nn823  0.335
2002 Howland DS, Liu J, She Y, Goad B, Maragakis NJ, Kim B, Erickson J, Kulik J, DeVito L, Psaltis G, DeGennaro LJ, Cleveland DW, Rothstein JD. Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS). Proceedings of the National Academy of Sciences of the United States of America. 99: 1604-9. PMID 11818550 DOI: 10.1073/pnas.032539299  0.65
2001 Watanabe M, Dykes-Hoberg M, Culotta VC, Price DL, Wong PC, Rothstein JD. Histological evidence of protein aggregation in mutant SOD1 transgenic mice and in amyotrophic lateral sclerosis neural tissues. Neurobiology of Disease. 8: 933-41. PMID 11741389 DOI: 10.1006/nbdi.2001.0443  0.364
2001 Maragakis NJ, Rothstein JD. Glutamate transporters in neurologic disease. Archives of Neurology. 58: 365-70. PMID 11255439 DOI: 10.1001/Archneur.58.3.365  0.572
2001 Rao VL, Dogan A, Todd KG, Bowen KK, Kim BT, Rothstein JD, Dempsey RJ. Antisense knockdown of the glial glutamate transporter GLT-1, but not the neuronal glutamate transporter EAAC1, exacerbates transient focal cerebral ischemia-induced neuronal damage in rat brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 1876-83. PMID 11245672 DOI: 10.1523/Jneurosci.21-06-01876.2001  0.37
2001 Jackson M, Song W, Liu MY, Jin L, Dykes-Hoberg M, Lin CI, Bowers WJ, Federoff HJ, Sternweis PC, Rothstein JD. Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins. Nature. 410: 89-93. PMID 11242047 DOI: 10.1038/35065091  0.367
2001 Lin CI, Orlov I, Ruggiero AM, Dykes-Hoberg M, Lee A, Jackson M, Rothstein JD. Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18. Nature. 410: 84-8. PMID 11242046 DOI: 10.1038/35065084  0.737
2001 Erkmen K, Teng YD, Sidman RL, Sheffner J, Snyder BD, Girolami UD, Ensrud E, Kosaras B, Kalkanis S, Brown RH, Rothstein J, Redmond DE, Snyder EY. 750 Transplantation of Human Neural Stem Cells in a New Primate Model of Motor Neuron Degeneration: An Experimental Study of Potential Cell Therapy for Amyotrophic Lateral Sclerosis Neurosurgery. 49: 521-521. DOI: 10.1097/00006123-200108000-00114  0.34
2000 Drachman DB, Rothstein JD. Inhibition of cyclooxygenase-2 protects motor neurons in an organotypic model of amyotrophic lateral sclerosis. Annals of Neurology. 48: 792-5. PMID 11079544 DOI: 10.1002/1531-8249(200011)48:5<792::AID-ANA14>3.0.CO;2-5  0.404
2000 Vos CM, Sjulson L, Nath A, McArthur JC, Pardo CA, Rothstein J, Conant K. Cytotoxicity by matrix metalloprotease-1 in organotypic spinal cord and dissociated neuronal cultures. Experimental Neurology. 163: 324-30. PMID 10833306 DOI: 10.1006/Exnr.2000.7388  0.32
2000 Raghavendra Rao VL, Rao AM, Dogan A, Bowen KK, Hatcher J, Rothstein JD, Dempsey RJ. Glial glutamate transporter GLT-1 down-regulation precedes delayed neuronal death in gerbil hippocampus following transient global cerebral ischemia. Neurochemistry International. 36: 531-7. PMID 10762090 DOI: 10.1016/S0197-0186(99)00153-9  0.354
2000 Zelenaia O, Schlag BD, Gochenauer GE, Ganel R, Song W, Beesley JS, Grinspan JB, Rothstein JD, Robinson MB. Epidermal growth factor receptor agonists increase expression of glutamate transporter GLT-1 in astrocytes through pathways dependent on phosphatidylinositol 3-kinase and transcription factor NF-kappaB. Molecular Pharmacology. 57: 667-78. PMID 10727511 DOI: 10.1124/Mol.57.4.667  0.357
2000 He Y, Janssen WG, Rothstein JD, Morrison JH. Differential synaptic localization of the glutamate transporter EAAC1 and glutamate receptor subunit GluR2 in the rat hippocampus. The Journal of Comparative Neurology. 418: 255-69. PMID 10701825 DOI: 10.1002/(SICI)1096-9861(20000313)418:3<255::AID-CNE2>3.0.CO;2-6  0.327
2000 Ho TW, Bristol LA, Coccia C, Li Y, Milbrandt J, Johnson E, Jin L, Bar-Peled O, Griffin JW, Rothstein JD. TGFbeta trophic factors differentially modulate motor axon outgrowth and protection from excitotoxicity. Experimental Neurology. 161: 664-75. PMID 10686085 DOI: 10.1006/Exnr.1999.7290  0.316
1999 Ye ZC, Rothstein JD, Sontheimer H. Compromised glutamate transport in human glioma cells: reduction-mislocalization of sodium-dependent glutamate transporters and enhanced activity of cystine-glutamate exchange. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 10767-77. PMID 10594060 DOI: 10.1523/Jneurosci.19-24-10767.1999  0.362
1999 Bar-Peled O, O'Brien RJ, Morrison JH, Rothstein JD. Cultured motor neurons possess calcium-permeable AMPA/kainate receptors. Neuroreport. 10: 855-9. PMID 10208560 DOI: 10.1097/00001756-199903170-00034  0.368
1999 Bar-Peled O, Knudson M, Korsmeyer SJ, Rothstein JD. Motor neuron degeneration is attenuated in bax-deficient neurons in vitro. Journal of Neuroscience Research. 55: 542-56. PMID 10082077 DOI: 10.1002/(SICI)1097-4547(19990301)55:5<542::AID-JNR2>3.0.CO;2-7  0.362
1999 Simantov R, Crispino M, Hoe W, Broutman G, Tocco G, Rothstein JD, Baudry M. Changes in expression of neuronal and glial glutamate transporters in rat hippocampus following kainate-induced seizure activity. Brain Research. Molecular Brain Research. 65: 112-23. PMID 10036313 DOI: 10.1016/S0169-328X(98)00349-0  0.369
1999 Rothstein JD, Dykes-Hoberg M, Corson LB, Becker M, Cleveland DW, Price DL, Culotta VC, Wong PC. The copper chaperone CCS is abundant in neurons and astrocytes in human and rodent brain. Journal of Neurochemistry. 72: 422-9. PMID 9886096 DOI: 10.1046/j.1471-4159.1999.0720422.x  0.378
1998 Wong PC, Rothstein JD, Price DL. The genetic and molecular mechanisms of motor neuron disease. Current Opinion in Neurobiology. 8: 791-9. PMID 9914243 DOI: 10.1016/S0959-4388(98)80123-2  0.338
1998 Meaney JA, Balcar VJ, Rothstein JD, Jeffrey PL. Glutamate transport in cultures from developing avian cerebellum: presence of GLT-1 immunoreactivity in Purkinje neurons. Journal of Neuroscience Research. 54: 595-603. PMID 9843150 DOI: 10.1002/(Sici)1097-4547(19981201)54:5<595::Aid-Jnr4>3.0.Co;2-Q  0.304
1998 Lin CL, Tzingounis AV, Jin L, Furuta A, Kavanaugh MP, Rothstein JD. Molecular cloning and expression of the rat EAAT4 glutamate transporter subtype. Brain Research. Molecular Brain Research. 63: 174-9. PMID 9838098 DOI: 10.1016/S0169-328X(98)00256-3  0.351
1998 Mennerick S, Dhond RP, Benz A, Xu W, Rothstein JD, Danbolt NC, Isenberg KE, Zorumski CF. Neuronal expression of the glutamate transporter GLT-1 in hippocampal microcultures. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 4490-9. PMID 9614226 DOI: 10.1523/Jneurosci.18-12-04490.1998  0.393
1998 Cooper B, Chebib M, Shen J, King NJ, Darvey IG, Kuchel PW, Rothstein JD, Balcar VJ. Structural selectivity and molecular nature of L-glutamate transport in cultured human fibroblasts. Archives of Biochemistry and Biophysics. 353: 356-64. PMID 9606970 DOI: 10.1006/Abbi.1998.0626  0.344
1998 Aoki M, Lin CL, Rothstein JD, Geller BA, Hosler BA, Munsat TL, Horvitz HR, Brown RH. Mutations in the glutamate transporter EAAT2 gene do not cause abnormal EAAT2 transcripts in amyotrophic lateral sclerosis. Annals of Neurology. 43: 645-53. PMID 9585360 DOI: 10.1002/Ana.410430514  0.32
1998 Rao VL, BaÅŸkaya MK, DoÄŸan A, Rothstein JD, Dempsey RJ. Traumatic brain injury down-regulates glial glutamate transporter (GLT-1 and GLAST) proteins in rat brain. Journal of Neurochemistry. 70: 2020-7. PMID 9572288 DOI: 10.1046/J.1471-4159.1998.70052020.X  0.348
1998 Lin CL, Bristol LA, Jin L, Dykes-Hoberg M, Crawford T, Clawson L, Rothstein JD. Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis. Neuron. 20: 589-602. PMID 9539131 DOI: 10.1016/S0896-6273(00)80997-6  0.402
1998 Matthews JC, Beveridge MJ, Malandro MS, Rothstein JD, Campbell-Thompson M, Verlander JW, Kilberg MS, Novak DA. Activity and protein localization of multiple glutamate transporters in gestation day 14 vs. day 20 rat placenta. The American Journal of Physiology. 274: C603-14. PMID 9530091 DOI: 10.1152/Ajpcell.1998.274.3.C603  0.316
1998 Davis KE, Straff DJ, Weinstein EA, Bannerman PG, Correale DM, Rothstein JD, Robinson MB. Multiple signaling pathways regulate cell surface expression and activity of the excitatory amino acid carrier 1 subtype of Glu transporter in C6 glioma. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 2475-85. PMID 9502808 DOI: 10.1523/Jneurosci.18-07-02475.1998  0.367
1997 Shayakul C, Kanai Y, Lee WS, Brown D, Rothstein JD, Hediger MA. Localization of the high-affinity glutamate transporter EAAC1 in rat kidney. The American Journal of Physiology. 273: F1023-9. PMID 9435692 DOI: 10.1152/Ajprenal.1997.273.6.F1023  0.305
1997 Coco S, Verderio C, Trotti D, Rothstein JD, Volterra A, Matteoli M. Non-synaptic localization of the glutamate transporter EAAC1 in cultured hippocampal neurons. The European Journal of Neuroscience. 9: 1902-10. PMID 9383213 DOI: 10.1111/J.1460-9568.1997.Tb00757.X  0.346
1997 Bar-Peled O, Ben-Hur H, Biegon A, Groner Y, Dewhurst S, Furuta A, Rothstein JD. Distribution of glutamate transporter subtypes during human brain development. Journal of Neurochemistry. 69: 2571-80. PMID 9375691 DOI: 10.1046/J.1471-4159.1997.69062571.X  0.351
1997 Martin LJ, Brambrink AM, Lehmann C, Portera-Cailliau C, Koehler R, Rothstein J, Traystman RJ. Hypoxia-ischemia causes abnormalities in glutamate transporters and death of astroglia and neurons in newborn striatum. Annals of Neurology. 42: 335-48. PMID 9307255 DOI: 10.1002/Ana.410420310  0.379
1997 O'Brien RJ, Mammen AL, Blackshaw S, Ehlers MD, Rothstein JD, Huganir RL. The development of excitatory synapses in cultured spinal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 7339-50. PMID 9295380 DOI: 10.1523/Jneurosci.17-19-07339.1997  0.313
1997 Keller JN, Mark RJ, Bruce AJ, Blanc E, Rothstein JD, Uchida K, Waeg G, Mattson MP. 4-Hydroxynonenal, an aldehydic product of membrane lipid peroxidation, impairs glutamate transport and mitochondrial function in synaptosomes. Neuroscience. 80: 685-96. PMID 9276486 DOI: 10.1016/S0306-4522(97)00065-1  0.348
1997 Liu MT, Rothstein JD, Gershon MD, Kirchgessner AL. Glutamatergic enteric neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 4764-84. PMID 9169536 DOI: 10.1523/Jneurosci.17-12-04764.1997  0.36
1997 Miller HP, Levey AI, Rothstein JD, Tzingounis AV, Conn PJ. Alterations in glutamate transporter protein levels in kindling-induced epilepsy. Journal of Neurochemistry. 68: 1564-70. PMID 9084427 DOI: 10.1046/J.1471-4159.1997.68041564.X  0.304
1997 Bruijn LI, Becher MW, Lee MK, Anderson KL, Jenkins NA, Copeland NG, Sisodia SS, Rothstein JD, Borchelt DR, Price DL, Cleveland DW. ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions. Neuron. 18: 327-38. PMID 9052802 DOI: 10.1016/S0896-6273(00)80272-X  0.412
1997 Swanson RA, Liu J, Miller JW, Rothstein JD, Farrell K, Stein BA, Longuemare MC. Neuronal regulation of glutamate transporter subtype expression in astrocytes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 932-40. PMID 8994048 DOI: 10.1523/Jneurosci.17-03-00932.1997  0.371
1997 Aoki M, Rothstein JD, Lin CG, Geller BA, Hosler BA, Munsat TL, Horvitz HR, Brown RH. Mutations of the glutamate transporter gene EAAT2 do not cause the abnormal EAAT2 transcripts in patients with amyotrophic lateral sclerosis Neuromuscular Disorders. 7: 475. DOI: 10.1016/S0960-8966(97)87358-0  0.334
1997 Bar-Peled O, Vornov J, O'Brien R, Morrison J, Knudson C, Korsmeyer S, Rothstein J. Enhanced susceptibility of motor neurons to excitotoxicity is dependent on Ca2+-permeable AMPA/kainate receptors and BAX expression Neuroscience Letters. 237: S7. DOI: 10.1016/S0304-3940(97)90027-6  0.336
1996 Rauen T, Rothstein JD, Wässle H. Differential expression of three glutamate transporter subtypes in the rat retina. Cell and Tissue Research. 286: 325-36. PMID 8929335 DOI: 10.1007/s004410050702  0.356
1996 Rothstein JD, Dykes-Hoberg M, Pardo CA, Bristol LA, Jin L, Kuncl RW, Kanai Y, Hediger MA, Wang Y, Schielke JP, Welty DF. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron. 16: 675-86. PMID 8785064 DOI: 10.1016/S0896-6273(00)80086-0  0.363
1996 Ginsberg SD, Rothstein JD, Price DL, Martin LJ. Fimbria-fornix transections selectively down-regulate subtypes of glutamate transporter and glutamate receptor proteins in septum and hippocampus. Journal of Neurochemistry. 67: 1208-16. PMID 8752128 DOI: 10.1046/J.1471-4159.1996.67031208.X  0.342
1996 Fine SM, Angel RA, Perry SW, Epstein LG, Rothstein JD, Dewhurst S, Gelbard HA. Tumor necrosis factor alpha inhibits glutamate uptake by primary human astrocytes. Implications for pathogenesis of HIV-1 dementia. The Journal of Biological Chemistry. 271: 15303-6. PMID 8663435 DOI: 10.1074/Jbc.271.26.15303  0.31
1995 Ginsberg SD, Martin LJ, Rothstein JD. Regional deafferentation down-regulates subtypes of glutamate transporter proteins. Journal of Neurochemistry. 65: 2800-3. PMID 7595581 DOI: 10.1046/J.1471-4159.1995.65062800.X  0.355
1994 Rothstein JD, Bristol LA, Hosler B, Brown RH, Kuncl RW. Chronic inhibition of superoxide dismutase produces apoptotic death of spinal neurons. Proceedings of the National Academy of Sciences of the United States of America. 91: 4155-9. PMID 7910402 DOI: 10.1073/Pnas.91.10.4155  0.399
1991 Tsai GC, Stauch-Slusher B, Sim L, Hedreen JC, Rothstein JD, Kuncl R, Coyle JT. Reductions in acidic amino acids and N-acetylaspartylglutamate in amyotrophic lateral sclerosis CNS. Brain Research. 556: 151-6. PMID 1682006 DOI: 10.1016/0006-8993(91)90560-I  0.345
1990 Rothstein JD, Tsai G, Kuncl RW, Clawson L, Cornblath DR, Drachman DB, Pestronk A, Stauch BL, Coyle JT. Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis. Annals of Neurology. 28: 18-25. PMID 2375630 DOI: 10.1002/ana.410280106  0.37
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