Li Gan - Publications

Gladstone Institute/UCSF, San Francisco, CA, United States 
 University of California, San Francisco, San Francisco, CA 
Cellular and Molecular Pathways in Neurodegeneration

32 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Zhan L, Krabbe G, Du F, Jones I, Reichert MC, Telpoukhovskaia M, Kodama L, Wang C, Cho SH, Sayed F, Li Y, Le D, Zhou Y, Shen Y, West B, ... Gan L, et al. Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain. Plos Biology. 17: e3000134. PMID 30735499 DOI: 10.1371/journal.pbio.3000134  0.32
2018 Sayed FA, Telpoukhovskaia M, Kodama L, Li Y, Zhou Y, Le D, Hauduc A, Ludwig C, Gao F, Clelland C, Zhan L, Cooper YA, Davalos D, Akassoglou K, Coppola G, ... Gan L, et al. Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy. Proceedings of the National Academy of Sciences of the United States of America. PMID 30232263 DOI: 10.1073/pnas.1811411115  0.32
2018 Willsey AJ, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA, Srivastava D, Davis GW, Doudna J, Chang E, Sohal V, ... ... Gan L, et al. The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders. Cell. 174: 505-520. PMID 30053424 DOI: 10.1016/j.cell.2018.06.016  1
2018 Martinez-Losa M, Tracy TE, Ma K, Verret L, Clemente-Perez A, Khan AS, Cobos I, Ho K, Gan L, Mucke L, Alvarez-Dolado M, Palop JJ. Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease. Neuron. PMID 29551491 DOI: 10.1016/j.neuron.2018.02.029  1
2017 Sha SJ, Miller ZA, Min SW, Zhou Y, Brown J, Mitic LL, Karydas A, Koestler M, Tsai R, Corbetta-Rastelli C, Lin S, Hare E, Fields S, Fleischmann KE, Powers R, ... ... Gan L, et al. An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from GRN gene mutations. Alzheimer's & Dementia (New York, N. Y.). 3: 507-512. PMID 29124108 DOI: 10.1016/j.trci.2017.08.002  0.32
2016 Sohn PD, Tracy TE, Son HI, Zhou Y, Leite RE, Miller BL, Seeley WW, Grinberg LT, Gan L. Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment. Molecular Neurodegeneration. 11: 47. PMID 27356871 DOI: 10.1186/s13024-016-0109-0  1
2016 Tracy TE, Sohn PD, Minami SS, Wang C, Min SW, Li Y, Zhou Y, Le D, Lo I, Ponnusamy R, Cong X, Schilling B, Ellerby LM, Huganir RL, Gan L. Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss. Neuron. PMID 27041503 DOI: 10.1016/j.neuron.2016.03.005  1
2015 Min SW, Chen X, Tracy TE, Li Y, Zhou Y, Wang C, Shirakawa K, Minami SS, Defensor E, Mok SA, Sohn PD, Schilling B, Cong X, Ellerby L, Gibson BW, ... ... Gan L, et al. Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits. Nature Medicine. PMID 26390242 DOI: 10.1038/nm.3951  1
2015 Gan L, Zhong J, Zhang R, Sun T, Li Q, Chen X, Zhang J. The Immediate Intramedullary Nailing Surgery Increased the Mitochondrial DNA Release That Aggravated Systemic Inflammatory Response and Lung Injury Induced by Elderly Hip Fracture. Mediators of Inflammation. 2015: 587378. PMID 26273137 DOI: 10.1155/2015/587378  1
2015 Minami SS, Shen V, Le D, Krabbe G, Asgarov R, Perez-Celajes L, Lee CH, Li J, Donnelly-Roberts D, Gan L. Reducing inflammation and rescuing FTD-related behavioral deficits in progranulin-deficient mice with α7 nicotinic acetylcholine receptor agonists. Biochemical Pharmacology. PMID 26206194 DOI: 10.1016/j.bcp.2015.07.016  1
2015 Cho SH, Chen JA, Sayed F, Ward ME, Gao F, Nguyen TA, Krabbe G, Sohn PD, Lo I, Minami S, Devidze N, Zhou Y, Coppola G, Gan L. SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1β. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 807-18. PMID 25589773 DOI: 10.1523/JNEUROSCI.2939-14.2015  1
2014 Minami SS, Min SW, Krabbe G, Wang C, Zhou Y, Asgarov R, Li Y, Martens LH, Elia LP, Ward ME, Mucke L, Farese RV, Gan L. Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models. Nature Medicine. 20: 1157-64. PMID 25261995 DOI: 10.1038/nm.3672  1
2014 Ward ME, Taubes A, Chen R, Miller BL, Sephton CF, Gelfand JM, Minami S, Boscardin J, Martens LH, Seeley WW, Yu G, Herz J, Filiano AJ, Arrant AE, Roberson ED, ... ... Gan L, et al. Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD. The Journal of Experimental Medicine. 211: 1937-45. PMID 25155018 DOI: 10.1084/jem.20140214  1
2013 Min SW, Sohn PD, Cho SH, Swanson RA, Gan L. Sirtuins in neurodegenerative diseases: an update on potential mechanisms. Frontiers in Aging Neuroscience. 5: 53. PMID 24093018 DOI: 10.3389/fnagi.2013.00053  1
2013 Kauppinen TM, Gan L, Swanson RA. Poly(ADP-ribose) polymerase-1-induced NAD(+) depletion promotes nuclear factor-κB transcriptional activity by preventing p65 de-acetylation. Biochimica Et Biophysica Acta. 1833: 1985-91. PMID 23597856 DOI: 10.1016/j.bbamcr.2013.04.005  1
2013 Grinberg LT, Wang X, Wang C, Sohn PD, Theofilas P, Sidhu M, Arevalo JB, Heinsen H, Huang EJ, Rosen H, Miller BL, Gan L, Seeley WW. Argyrophilic grain disease differs from other tauopathies by lacking tau acetylation. Acta Neuropathologica. 125: 581-93. PMID 23371364 DOI: 10.1007/s00401-013-1080-2  1
2012 Martens LH, Zhang J, Barmada SJ, Zhou P, Kamiya S, Sun B, Min SW, Gan L, Finkbeiner S, Huang EJ, Farese RV. Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury. The Journal of Clinical Investigation. 122: 3955-9. PMID 23041626 DOI: 10.1172/JCI63113  1
2012 Wang C, Sun B, Zhou Y, Grubb A, Gan L. Cathepsin B degrades amyloid-β in mice expressing wild-type human amyloid precursor protein. The Journal of Biological Chemistry. 287: 39834-41. PMID 23024364 DOI: 10.1074/jbc.M112.371641  0.32
2012 Minami SS, Sun B, Popat K, Kauppinen T, Pleiss M, Zhou Y, Ward ME, Floreancig P, Mucke L, Desai T, Gan L. Selective targeting of microglia by quantum dots. Journal of Neuroinflammation. 9: 22. PMID 22272874 DOI: 10.1186/1742-2094-9-22  1
2011 Kauppinen TM, Suh SW, Higashi Y, Berman AE, Escartin C, Won SJ, Wang C, Cho SH, Gan L, Swanson RA. Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid β. Journal of Neuroinflammation. 8: 152. PMID 22051244 DOI: 10.1186/1742-2094-8-152  1
2011 Zhang F, Wang S, Gan L, Vosler PS, Gao Y, Zigmond MJ, Chen J. Protective effects and mechanisms of sirtuins in the nervous system. Progress in Neurobiology. 95: 373-95. PMID 21930182 DOI: 10.1016/j.pneurobio.2011.09.001  1
2011 Cho SH, Sun B, Zhou Y, Kauppinen TM, Halabisky B, Wes P, Ransohoff RM, Gan L. CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease. The Journal of Biological Chemistry. 286: 32713-22. PMID 21771791 DOI: 10.1074/jbc.M111.254268  1
2010 Min SW, Cho SH, Zhou Y, Schroeder S, Haroutunian V, Seeley WW, Huang EJ, Shen Y, Masliah E, Mukherjee C, Meyers D, Cole PA, Ott M, Gan L. Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron. 67: 953-66. PMID 20869593 DOI: 10.1016/j.neuron.2010.08.044  1
2009 Sun B, Halabisky B, Zhou Y, Palop JJ, Yu G, Mucke L, Gan L. Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease. Cell Stem Cell. 5: 624-33. PMID 19951690 DOI: 10.1016/j.stem.2009.10.003  1
2008 Sun B, Zhou Y, Halabisky B, Lo I, Cho SH, Mueller-Steiner S, Devidze N, Wang X, Grubb A, Gan L. Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease. Neuron. 60: 247-57. PMID 18957217 DOI: 10.1016/j.neuron.2008.10.001  1
2008 Sanchez-Mejia RO, Newman JW, Toh S, Yu GQ, Zhou Y, Halabisky B, Cissé M, Scearce-Levie K, Cheng IH, Gan L, Palop JJ, Bonventre JV, Mucke L. Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease. Nature Neuroscience. 11: 1311-8. PMID 18931664 DOI: 10.1038/nn.2213  1
2008 Gan L, Mucke L. Paths of convergence: sirtuins in aging and neurodegeneration. Neuron. 58: 10-4. PMID 18400158 DOI: 10.1016/j.neuron.2008.03.015  1
2006 Mueller-Steiner S, Zhou Y, Arai H, Roberson ED, Sun B, Chen J, Wang X, Yu G, Esposito L, Mucke L, Gan L. Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease. Neuron. 51: 703-14. PMID 16982417 DOI: 10.1016/j.neuron.2006.07.027  1
2005 Chen J, Zhou Y, Mueller-Steiner S, Chen LF, Kwon H, Yi S, Mucke L, Gan L. SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling. The Journal of Biological Chemistry. 280: 40364-74. PMID 16183991 DOI: 10.1074/jbc.M509329200  1
2005 Kaczmarek LK, Bhattacharjee A, Desai R, Gan L, Song P, von Hehn CA, Whim MD, Yang B. Regulation of the timing of MNTB neurons by short-term and long-term modulation of potassium channels. Hearing Research. 206: 133-45. PMID 16081004 DOI: 10.1016/j.heares.2004.11.023  1
2004 Esposito L, Gan L, Yu GQ, Essrich C, Mucke L. Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells. Journal of Neurochemistry. 91: 1260-74. PMID 15584903 DOI: 10.1111/j.1471-4159.2004.02816.x  1
2002 Bhattacharjee A, Gan L, Kaczmarek LK. Localization of the Slack potassium channel in the rat central nervous system. The Journal of Comparative Neurology. 454: 241-54. PMID 12442315 DOI: 10.1002/cne.10439  1
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