Emily M. Jutkiewicz, Ph.D. - Publications

Affiliations: 
University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
behavioral pharmacology

50/62 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Henry S, Anand JP, Twarozynski JJ, Brinkel AC, Pogozheva ID, Sears BF, Jutkiewicz EM, Traynor JR, Mosberg HI. Aromatic-Amine Pendants Produce Highly Potent and Efficacious Mixed Efficacy Mu-Opioid Receptor (MOR)/Delta-Opioid Receptor (DOR) Peptidomimetics with Enhanced Metabolic Stability. Journal of Medicinal Chemistry. PMID 31986033 DOI: 10.1021/acs.jmedchem.9b01818  0.64
2020 Winger G, Jutkiewicz EM, Woods JH. Comparison of the muscarinic antagonist effects of scopolamine and L-687,306. Behavioural Pharmacology. PMID 31922966 DOI: 10.1097/FBP.0000000000000537  0.92
2019 Nastase AF, Anand JP, Bender AM, Montgomery D, Griggs N, Fernandez TJ, Jutkiewicz EM, Traynor JR, Mosberg HI. Dual Pharmacophores Explored via Structure-Activity Relationship (SAR) Matrix: Insights into Potent, Bifunctional Opioid Ligand Design. Journal of Medicinal Chemistry. PMID 30916966 DOI: 10.1021/acs.jmedchem.9b00378  0.64
2018 Senese NB, Oginsky M, Neubig RR, Ferrario C, Jutkiewicz EM, Traynor JR. Role of hippocampal 5-HT1A receptors in the antidepressant-like phenotype of mice expressing RGS-insensitive Gαi2 protein. Neuropharmacology. 141: 296-304. PMID 30189184 DOI: 10.1016/j.neuropharm.2018.09.002  0.64
2018 Nastase AF, Griggs NW, Anand JP, Fernandez TJ, Harland AA, Trask TJ, Jutkiewicz EM, Traynor JR, Mosberg HI. Synthesis and pharmacological evaluation of novel C-8 substituted tetrahydroquinolines as balanced-affinity mu/delta opioid ligands for the treatment of pain. Acs Chemical Neuroscience. PMID 29677442 DOI: 10.1021/acschemneuro.8b00139  0.64
2018 Anand JP, Kochan KE, Nastase AF, Montgomery D, Griggs NW, Traynor JR, Mosberg HI, Jutkiewicz EM. In Vivo Effects of μ Opioid Receptor Agonist/δ Opioid Receptor Antagonist Peptidomimetics Following Acute and Repeated Administration. British Journal of Pharmacology. PMID 29352503 DOI: 10.1111/bph.14148  0.64
2017 Dripps IJ, Boyer BT, Neubig RR, Rice KC, Traynor JR, Jutkiewicz EM. Role of signaling molecules in behaviors mediated by the δ-receptor agonist SNC80. British Journal of Pharmacology. PMID 29278419 DOI: 10.1111/bph.14131  0.64
2017 Lamberts JT, Rosenthal LD, Jutkiewicz EM, Traynor JR. Role of the guanine nucleotide binding protein, Gαo, in the development of morphine tolerance and dependence. Psychopharmacology. PMID 28971229 DOI: 10.1007/s00213-017-4742-2  0.64
2016 Dripps IJ, Wang Q, Neubig RR, Rice KC, Traynor JR, Jutkiewicz EM. The role of regulator of G protein signaling 4 in delta-opioid receptor-mediated behaviors. Psychopharmacology. PMID 27624599 DOI: 10.1007/s00213-016-4432-5  0.64
2016 Harland AA, Bender AM, Griggs NW, Gao C, Anand JP, Pogozheva ID, Traynor JR, Jutkiewicz EM, Mosberg HI. Effects of N-Substitutions on the Tetrahydroquinoline (THQ) core of Mixed-Efficacy μ-Opioid Receptor (MOR)/ δ-Opioid Receptor (DOR) Ligands. Journal of Medicinal Chemistry. PMID 27148755 DOI: 10.1021/acs.jmedchem.6b00308  0.92
2016 Anand JP, Boyer BT, Mosberg HI, Jutkiewicz EM. The behavioral effects of a mixed efficacy antinociceptive peptide, VRP26, following chronic administration in mice. Psychopharmacology. PMID 27117141 DOI: 10.1007/s00213-016-4296-8  0.92
2015 Harland AA, Yeomans L, Griggs NW, Anand JP, Pogozheva ID, Jutkiewicz EM, Traynor JR, Mosberg HI. Further Optimization and Evaluation of Bioavailable, Mixed-Efficacy μ-Opioid Receptor (MOR) Agonists/ δ-Opioid Receptor (DOR) Antagonists: Balancing MOR and DOR Affinities. Journal of Medicinal Chemistry. PMID 26524472 DOI: 10.1021/acs.jmedchem.5b01270  0.92
2015 Vollbrecht PJ, Nobile CW, Chadderdon AM, Jutkiewicz EM, Ferrario CR. Pre-existing differences in motivation for food and sensitivity to cocaine-induced locomotion in obesity-prone rats. Physiology & Behavior. 152: 151-160. PMID 26423787 DOI: 10.1016/j.physbeh.2015.09.022  0.92
2015 Bender AM, Griggs NW, Anand JP, Traynor JR, Jutkiewicz EM, Mosberg HI. Asymmetric Synthesis and in Vitro and in Vivo Activity of Tetrahydroquinolines Featuring a Diverse Set of Polar Substitutions at the 6 Position as Mixed-Efficacy μ Opioid Receptor/δ Opioid Receptor Ligands. Acs Chemical Neuroscience. 6: 1428-35. PMID 25938166 DOI: 10.1021/acschemneuro.5b00100  0.92
2015 Blazer LL, Storaska AJ, Jutkiewicz EM, Turner EM, Calcagno M, Wade SM, Wang Q, Huang XP, Traynor JR, Husbands SM, Morari M, Neubig RR. Selectivity and Anti-Parkinson's Potential of Thiadiazolidinone RGS4 Inhibitors. Acs Chemical Neuroscience. 6: 911-9. PMID 25844489 DOI: 10.1021/acschemneuro.5b00063  0.92
2015 Blum JM, Biel SS, Hilliard PE, Jutkiewicz EM. Preoperative ultra-rapid opiate detoxification for the treatment of post-operative surgical pain. Medical Hypotheses. 84: 529-31. PMID 25816931 DOI: 10.1016/j.mehy.2015.02.008  0.92
2015 Eagle AL, Singh R, Kohler RJ, Friedman AL, Liebowitz CP, Galloway MP, Enman NM, Jutkiewicz EM, Perrine SA. Single prolonged stress effects on sensitization to cocaine and cocaine self-administration in rats. Behavioural Brain Research. 284: 218-24. PMID 25712697 DOI: 10.1016/j.bbr.2015.02.027  0.92
2014 Mabrouk OS, Dripps IJ, Ramani S, Chang C, Han JL, Rice KC, Jutkiewicz EM. Automated touch screen device for recording complex rodent behaviors. Journal of Neuroscience Methods. 233: 129-36. PMID 24952323 DOI: 10.1016/j.jneumeth.2014.05.004  0.92
2014 Mosberg HI, Yeomans L, Anand JP, Porter V, Sobczyk-Kojiro K, Traynor JR, Jutkiewicz EM. Development of a bioavailable μ opioid receptor (MOPr) agonist, δ opioid receptor (DOPr) antagonist peptide that evokes antinociception without development of acute tolerance. Journal of Medicinal Chemistry. 57: 3148-53. PMID 24641190 DOI: 10.1021/jm5002088  0.92
2014 Bosse KE, Jutkiewicz EM, Schultz-Kuszak KN, Mabrouk OS, Kennedy RT, Gnegy ME, Traynor JR. Synergistic activity between the delta-opioid agonist SNC80 and amphetamine occurs via a glutamatergic NMDA-receptor dependent mechanism. Neuropharmacology. 77: 19-27. PMID 24035916 DOI: 10.1016/j.neuropharm.2013.08.027  0.92
2013 Mosberg HI, Yeomans L, Harland AA, Bender AM, Sobczyk-Kojiro K, Anand JP, Clark MJ, Jutkiewicz EM, Traynor JR. Opioid peptidomimetics: leads for the design of bioavailable mixed efficacy μ opioid receptor (MOR) agonist/δ opioid receptor (DOR) antagonist ligands. Journal of Medicinal Chemistry. 56: 2139-49. PMID 23419026 DOI: 10.1021/jm400050y  0.92
2013 Jutkiewicz EM, Rice KC, Carroll FI, Woods JH. Patterns of nicotinic receptor antagonism II: cardiovascular effects in rats. Drug and Alcohol Dependence. 131: 284-97. PMID 23333294 DOI: 10.1016/j.drugalcdep.2012.12.021  0.92
2011 Ohmura Y, Jutkiewicz EM, Yoshioka M, Domino EF. 5-Hydroxytryptophan attenuates somatic signs of nicotine withdrawal. Journal of Pharmacological Sciences. 117: 121-4. PMID 22001627 DOI: JST.JSTAGE/jphs/11074SC  0.92
2011 Jutkiewicz EM, Brooks EA, Kynaston AD, Rice KC, Woods JH. Patterns of nicotinic receptor antagonism: nicotine discrimination studies. The Journal of Pharmacology and Experimental Therapeutics. 339: 194-202. PMID 21730011 DOI: 10.1124/jpet.111.182170  0.92
2011 Lamberts JT, Jutkiewicz EM, Mortensen RM, Traynor JR. μ-Opioid receptor coupling to Gα(o) plays an important role in opioid antinociception. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 2041-53. PMID 21654736 DOI: 10.1038/npp.2011.91  0.92
2011 Ohmura Y, Jutkiewicz EM, Zhang A, Domino EF. Dopamine D1/5 and D2/3 agonists differentially attenuate somatic signs of nicotine withdrawal in rats. Pharmacology, Biochemistry, and Behavior. 99: 552-6. PMID 21624384 DOI: 10.1016/j.pbb.2011.05.010  0.92
2011 Ohmura Y, Jutkiewicz EM, Domino EF. L-DOPA attenuates nicotine withdrawal-induced behaviors in rats. Pharmacology, Biochemistry, and Behavior. 98: 552-8. PMID 21354201 DOI: 10.1016/j.pbb.2011.02.007  0.92
2010 Talbot JN, Jutkiewicz EM, Graves SM, Clemans CF, Nicol MR, Mortensen RM, Huang X, Neubig RR, Traynor JR. RGS inhibition at G(alpha)i2 selectively potentiates 5-HT1A-mediated antidepressant effects. Proceedings of the National Academy of Sciences of the United States of America. 107: 11086-91. PMID 20534514 DOI: 10.1073/pnas.1000003107  0.92
2010 Jutkiewicz EM, Baladi MG, Cooper ZD, Woods JH. In reply Annals of Emergency Medicine. 55: 485-486. DOI: 10.1016/j.annemergmed.2009.11.028  0.92
2009 Singer BH, Jutkiewicz EM, Fuller CL, Lichtenwalner RJ, Zhang H, Velander AJ, Li X, Gnegy ME, Burant CF, Parent JM. Conditional ablation and recovery of forebrain neurogenesis in the mouse. The Journal of Comparative Neurology. 514: 567-82. PMID 19363795 DOI: 10.1002/cne.22052  0.92
2009 Jutkiewicz EM, Baladi MG, Cooper ZD, Narasimhan D, Sunahara RK, Woods JH. A bacterial cocaine esterase protects against cocaine-induced epileptogenic activity and lethality. Annals of Emergency Medicine. 54: 409-20. PMID 19013687 DOI: 10.1016/j.annemergmed.2008.09.023  0.92
2008 Bosse KE, Jutkiewicz EM, Gnegy ME, Traynor JR. The selective delta opioid agonist SNC80 enhances amphetamine-mediated efflux of dopamine from rat striatum. Neuropharmacology. 55: 755-62. PMID 18602932 DOI: 10.1016/j.neuropharm.2008.06.017  0.92
2008 Jutkiewicz EM, Baladi MG, Folk JE, Rice KC, Woods JH. The delta-opioid receptor agonist SNC80 [(+)-4-[alpha(R)-alpha-[(2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl]-(3-methoxybenzyl)-N,N-diethylbenzamide] synergistically enhances the locomotor-activating effects of some psychomotor stimulants, but not direct dopamine agonists, in rats. The Journal of Pharmacology and Experimental Therapeutics. 324: 714-24. PMID 17986650 DOI: 10.1124/jpet.107.123844  0.92
2007 Jutkiewicz EM. RB101-mediated protection of endogenous opioids: potential therapeutic utility? Cns Drug Reviews. 13: 192-205. PMID 17627672 DOI: 10.1111/j.1527-3458.2007.00011.x  0.56
2006 Cooper ZD, Narasimhan D, Sunahara RK, Mierzejewski P, Jutkiewicz EM, Larsen NA, Wilson IA, Landry DW, Woods JH. Rapid and robust protection against cocaine-induced lethality in rats by the bacterial cocaine esterase. Molecular Pharmacology. 70: 1885-91. PMID 16968810 DOI: 10.1124/mol.106.025999  0.92
2006 Jutkiewicz EM. The antidepressant -like effects of delta-opioid receptor agonists. Molecular Interventions. 6: 162-9. PMID 16809477 DOI: 10.1124/mi.6.3.7  0.72
2006 Jutkiewicz EM, Baladi MG, Folk JE, Rice KC, Woods JH. The convulsive and electroencephalographic changes produced by nonpeptidic delta-opioid agonists in rats: comparison with pentylenetetrazol. The Journal of Pharmacology and Experimental Therapeutics. 317: 1337-48. PMID 16537798 DOI: 10.1124/jpet.105.095810  0.92
2006 Zhang H, Torregrossa MM, Jutkiewicz EM, Shi YG, Rice KC, Woods JH, Watson SJ, Ko MC. Endogenous opioids upregulate brain-derived neurotrophic factor mRNA through delta- and micro-opioid receptors independent of antidepressant-like effects. The European Journal of Neuroscience. 23: 984-94. PMID 16519663 DOI: 10.1111/j.1460-9568.2006.04621.x  0.92
2006 Jutkiewicz EM, Torregrossa MM, Sobczyk-Kojiro K, Mosberg HI, Folk JE, Rice KC, Watson SJ, Woods JH. Behavioral and neurobiological effects of the enkephalinase inhibitor RB101 relative to its antidepressant effects. European Journal of Pharmacology. 531: 151-9. PMID 16442521 DOI: 10.1016/j.ejphar.2005.12.002  0.92
2006 Torregrossa MM, Jutkiewicz EM, Mosberg HI, Balboni G, Watson SJ, Woods JH. Peptidic delta opioid receptor agonists produce antidepressant-like effects in the forced swim test and regulate BDNF mRNA expression in rats. Brain Research. 1069: 172-81. PMID 16364263 DOI: 10.1016/j.brainres.2005.11.005  0.92
2005 Jutkiewicz EM, Rice KC, Traynor JR, Woods JH. Separation of the convulsions and antidepressant-like effects produced by the delta-opioid agonist SNC80 in rats. Psychopharmacology. 182: 588-96. PMID 16163520 DOI: 10.1007/s00213-005-0138-9  0.92
2005 Jutkiewicz EM, Kaminsky ST, Rice KC, Traynor JR, Woods JH. Differential behavioral tolerance to the delta-opioid agonist SNC80 ([(+)-4-[(alphaR)-alpha-[(2S,5R)-2,5-dimethyl-4-(2-propenyl)-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide) in Sprague-Dawley rats. The Journal of Pharmacology and Experimental Therapeutics. 315: 414-22. PMID 16014751 DOI: 10.1124/jpet.105.088831  0.92
2005 Jutkiewicz EM, Wood SK, Houshyar H, Hsin LW, Rice KC, Woods JH. The effects of CRF antagonists, antalarmin, CP154,526, LWH234, and R121919, in the forced swim test and on swim-induced increases in adrenocorticotropin in rats. Psychopharmacology. 180: 215-23. PMID 15696320 DOI: 10.1007/s00213-005-2164-z  0.92
2005 Jutkiewicz EM, Walker NP, Folk JE, Rice KC, Portoghese PS, Woods JH, Traynor JR. Comparison of peptidic and nonpeptidic delta-opioid agonists on guanosine 5'-O-(3-[35S]thio)triphosphate ([35S]GTPgammaS) binding in brain slices from Sprague-Dawley rats. The Journal of Pharmacology and Experimental Therapeutics. 312: 1314-20. PMID 15574687 DOI: 10.1124/jpet.104.078741  0.92
2004 Jutkiewicz EM, Bergman J. Effects of dopamine D1 ligands on eye blinking in monkeys: efficacy, antagonism, and D1/D2 interactions. The Journal of Pharmacology and Experimental Therapeutics. 311: 1008-15. PMID 15292458 DOI: 10.1124/jpet.104.071092  0.92
2004 Jutkiewicz EM, Eller EB, Folk JE, Rice KC, Traynor JR, Woods JH. Delta-opioid agonists: differential efficacy and potency of SNC80, its 3-OH (SNC86) and 3-desoxy (SNC162) derivatives in Sprague-Dawley rats. The Journal of Pharmacology and Experimental Therapeutics. 309: 173-81. PMID 14722329 DOI: 10.1124/jpet.103.061242  0.92
2003 Jutkiewicz EM, Rice KC, Woods JH, Winsauer PJ. Effects of the delta-opioid receptor agonist SNC80 on learning relative to its antidepressant-like effects in rats. Behavioural Pharmacology. 14: 509-16. PMID 14557718 DOI: 10.1097/01.fbp.0000095080.80017.9d  0.92
2002 Broom DC, Jutkiewicz EM, Rice KC, Traynor JR, Woods JH. Behavioral effects of delta-opioid receptor agonists: potential antidepressants? Japanese Journal of Pharmacology. 90: 1-6. PMID 12396021 DOI: 10.1254/jjp.90.1  0.92
2002 Broom DC, Jutkiewicz EM, Folk JE, Traynor JR, Rice KC, Woods JH. Convulsant activity of a non-peptidic delta-opioid receptor agonist is not required for its antidepressant-like effects in Sprague-Dawley rats. Psychopharmacology. 164: 42-8. PMID 12373418 DOI: 10.1007/s00213-002-1179-y  0.92
2002 Broom DC, Jutkiewicz EM, Folk JE, Traynor JR, Rice KC, Woods JH. Nonpeptidic delta-opioid receptor agonists reduce immobility in the forced swim assay in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 26: 744-55. PMID 12007745 DOI: 10.1016/S0893-133X(01)00413-4  0.92
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2017 McCabe SE, West BT, Jutkiewicz EM, Boyd CJ. Multiple DSM-5 substance use disorders: A national study of US adults. Human Psychopharmacology. PMID 28750478 DOI: 10.1002/hup.2625  0.24
2019 Friedman AL, Meurice C, Jutkiewicz EM. Effects of adolescent Δ9-tetrahydrocannabinol exposure on the behavioral effects of cocaine in adult Sprague-Dawley rats. Experimental and Clinical Psychopharmacology. PMID 30932503 DOI: 10.1037/pha0000276  0.2
2018 Vicente-Sanchez A, Dripps IJ, Tipton AF, Akbari H, Akbari A, Jutkiewicz EM, Pradhan AA. Tolerance to high-internalizing delta opioid receptor agonist is critically mediated by arrestin 2. British Journal of Pharmacology. PMID 29722902 DOI: 10.1111/bph.14353  0.12
2017 Dripps IJ, Jutkiewicz EM. Delta Opioid Receptors and Modulation of Mood and Emotion. Handbook of Experimental Pharmacology. PMID 28993835 DOI: 10.1007/164_2017_42  0.12
2017 Jin Y, Huang X, Papke RL, Jutkiewicz EM, Showalter HD, Zhan CG. Design, synthesis, and biological activity of 5'-phenyl-1,2,5,6-tetrahydro-3,3'-bipyridine analogues as potential antagonists of nicotinic acetylcholine receptors. Bioorganic & Medicinal Chemistry Letters. PMID 28838693 DOI: 10.1016/j.bmcl.2017.08.025  0.12
2019 Altshuler RD, Carpenter CA, Franke TJ, Gnegy ME, Jutkiewicz EM. Correction to: The protein kinase Cβ-selective inhibitor, enzastaurin, attenuates amphetamine-stimulated locomotor activity and self-administration behaviors in rats. Psychopharmacology. PMID 31270556 DOI: 10.1007/s00213-019-05312-1  0.08
2019 Altshuler RD, Carpenter CC, Franke TJ, Gnegy ME, Jutkiewicz EM. The protein kinase Cβ-selective inhibitor, enzastaurin, attenuates amphetamine-stimulated locomotor activity and self-administration behaviors in rats. Psychopharmacology. PMID 31134292 DOI: 10.1007/s00213-019-05278-0  0.08
2011 Kim MN, Jutkiewicz EM, Zhang M, Gnegy ME. The sensitizing effect of acute nicotine on amphetamine-stimulated behavior and dopamine efflux requires activation of β2 subunit-containing nicotinic acetylcholine receptors and glutamate N-methyl-D-aspartate receptors. Neuropharmacology. 60: 1126-34. PMID 20971124 DOI: 10.1016/j.neuropharm.2010.10.003  0.08
2008 Jutkiewicz EM, Nicolazzo DM, Kim MN, Gnegy ME. Nicotine and amphetamine acutely cross-potentiate their behavioral and neurochemical responses in female Holtzman rats. Psychopharmacology. 200: 93-103. PMID 18566803 DOI: 10.1007/s00213-008-1159-y  0.08
2018 Jutkiewicz EM. Correction to: Delta Opioid Receptor Pharmacology and Therapeutic Applications. Handbook of Experimental Pharmacology. 247: C1-C2. PMID 31309359 DOI: 10.1007/978-3-319-95133-1_1001  0.01
2017 Vollbrecht PJ, Nesbitt KM, Mabrouk OS, Chadderdon AM, Jutkiewicz EM, Kennedy RT, Ferrario CR. Cocaine and desipramine elicit distinct striatal noradrenergic and behavioral responses in selectively bred obesity-resistant and obesity-prone rats. Behavioural Brain Research. PMID 29129597 DOI: 10.1016/j.bbr.2017.11.009  0.01
2012 Jutkiewicz EM, Roques BP. Endogenous opioids as physiological antidepressants: complementary role of δ receptors and dopamine. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 303-4. PMID 22157869 DOI: 10.1038/npp.2011.244  0.01
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