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Paul G. DeCaen, Ph.D. - Publications

Affiliations: 
University of Washington, Seattle, Seattle, WA 
Area:
Calcium channels
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46 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Larmore M, Palomero OE, Kamat NP, DeCaen PG. A synthetic method to assay polycystin channel biophysics. Biorxiv : the Preprint Server For Biology. PMID 38766162 DOI: 10.1101/2024.05.06.592666  0.474
2023 Vien TN, Ta MC, Kimura LF, Onay T, DeCaen PG. Primary cilia TRP channel regulates hippocampal excitability. Proceedings of the National Academy of Sciences of the United States of America. 120: e2219686120. PMID 37216541 DOI: 10.1073/pnas.2219686120  0.315
2023 Ng LC, Harris BJ, Larmore M, Ta MC, Vien TN, Tokars VL, Yarov-Yarovoy V, DeCaen PG. Energetic landscape of polycystin channel gating. Embo Reports. e56783. PMID 37158562 DOI: 10.15252/embr.202356783  0.474
2023 Esarte Palomero O, Larmore M, DeCaen PG. Polycystin Channel Complexes. Annual Review of Physiology. 85: 425-448. PMID 36763973 DOI: 10.1146/annurev-physiol-031522-084334  0.502
2021 Sula A, Hollingworth D, Ng LCT, Larmore M, DeCaen PG, Wallace BA. A tamoxifen receptor within a voltage-gated sodium channel. Molecular Cell. PMID 33503406 DOI: 10.1016/j.molcel.2020.12.048  0.448
2020 Vien TN, Ng LCT, Smith JM, Dong K, Krappitz M, Gainullin VG, Fedeles S, Harris PC, Somlo S, DeCaen PG. Disrupting Polycystin-2 EF hand Ca affinity does not alter channel function or contribute to polycystic kidney disease. Journal of Cell Science. PMID 33199522 DOI: 10.1242/jcs.255562  0.347
2020 Vien TN, Wang J, Ng LCT, Cao E, DeCaen PG. Molecular dysregulation of ciliary polycystin-2 channels caused by variants in the TOP domain. Proceedings of the National Academy of Sciences of the United States of America. PMID 32332171 DOI: 10.1073/Pnas.1920777117  0.529
2020 Ta CM, Vien TN, Ng LCT, DeCaen PG. Structure and function of polycystin channels in primary cilia. Cellular Signalling. 109626. PMID 32251715 DOI: 10.1016/J.Cellsig.2020.109626  0.545
2020 Vien T, Wang J, Ng LC, Cao E, DeCaen PG. Molecular Regulation of Polycystin TRP Channels Biophysical Journal. 118: 324a. DOI: 10.1016/J.Bpj.2019.11.1821  0.518
2019 Zanatta G, Sula A, Miles AJ, Ng LCT, Torella R, Pryde DC, DeCaen PG, Wallace BA. Valproic acid interactions with the NavMs voltage-gated sodium channel. Proceedings of the National Academy of Sciences of the United States of America. PMID 31822620 DOI: 10.1073/Pnas.1909696116  0.574
2019 Yarov-Yarovoy V, DeCaen P. The Sodium Channel Voltage Sensor Slides to Rest. Trends in Pharmacological Sciences. PMID 31495454 DOI: 10.1016/J.Tips.2019.08.009  0.538
2019 Ng LCT, Vien TN, Yarov-Yarovoy V, DeCaen PG. Opening TRPP2 () requires the transfer of gating charges. Proceedings of the National Academy of Sciences of the United States of America. PMID 31315976 DOI: 10.1073/Pnas.1902917116  0.646
2019 Blair NT, Carvacho I, Chaudhuri D, Clapham DE, DeCaen P, Delling M, Doerner JF, Fan L, Ha K, Jordt SE, Julius D, Kahle KT, Liu B, McKemy D, Nilius B, et al. Transient Receptor Potential channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f78/2019.4  0.496
2019 CT Ng L, Vien TN, Mukhopadhyay A, DeCaen PG. Essential Residues Required for the Opening of a Polycystin TRP Channel Biophysical Journal. 116: 535a. DOI: 10.1016/J.Bpj.2018.11.2878  0.555
2018 Liu X, Vien T, Duan J, Sheu SH, DeCaen PG, Clapham DE. Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium. Elife. 7. PMID 29443690 DOI: 10.7554/Elife.33183  0.535
2017 Abiria SA, Krapivinsky G, Sah R, Santa-Cruz AG, Chaudhuri D, Zhang J, Adstamongkonkul P, DeCaen PG, Clapham DE. TRPM7 senses oxidative stress to release Zn(2+) from unique intracellular vesicles. Proceedings of the National Academy of Sciences of the United States of America. PMID 28696294 DOI: 10.1073/Pnas.1707380114  0.313
2017 Tang C, Zhou X, Nguyen PT, Zhang Y, Hu Z, Zhang C, Yarov-Yarovoy V, DeCaen PG, Liang S, Liu Z. A novel tarantula toxin stabilizes the deactivated voltage sensor of bacterial sodium channel. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28400471 DOI: 10.1016/J.Toxicon.2018.10.138  0.55
2017 Sula A, Booker J, Ng LC, Naylor CE, DeCaen PG, Wallace BA. The complete structure of an activated open sodium channel. Nature Communications. 8: 14205. PMID 28205548 DOI: 10.1038/Ncomms14205  0.625
2016 Pablo JL, DeCaen PG, Clapham DE. Progress in ciliary ion channel physiology. The Journal of General Physiology. PMID 27999145 DOI: 10.1085/Jgp.201611696  0.487
2016 Shen PS, Yang X, DeCaen PG, Liu X, Bulkley D, Clapham DE, Cao E. The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs. Cell. 167: 763-773.e11. PMID 27768895 DOI: 10.1016/J.Cell.2016.09.048  0.589
2016 Vien TN, DeCaen PG. Biophysical Adaptations of Prokaryotic Voltage-Gated Sodium Channels. Current Topics in Membranes. 78: 39-64. PMID 27586280 DOI: 10.1016/Bs.Ctm.2015.12.003  0.518
2016 DeCaen PG, Liu X, Abiria S, Clapham DE. Atypical calcium regulation of the PKD2-L1 polycystin ion channel. Elife. 5. PMID 27348301 DOI: 10.7554/Elife.13413  0.491
2016 Naylor CE, Bagnéris C, DeCaen PG, Sula A, Scaglione A, Clapham DE, Wallace BA. Molecular basis of ion permeability in a voltage-gated sodium channel. The Embo Journal. PMID 26873592 DOI: 10.15252/Embj.201593285  0.578
2016 DeCaen PG, Liu X, Abiria S, Clapham DE. Author response: Atypical calcium regulation of the PKD2-L1 polycystin ion channel Elife. DOI: 10.7554/Elife.13413.021  0.466
2016 Sula A, DeCaen P, Naylor C, Zanatta G, Bagneris C, Clapham DE, Pryde D, Wallace B. Sodium Channel/Ligand Complex Structures as a Guide for Rational Drug Design Biophysical Journal. 110: 33a. DOI: 10.1016/J.Bpj.2015.11.248  0.53
2015 Naylor CE, Bagneris C, DeCaen PG, Clapham DE, Wallace B. Sodium Ion Coordination in the Selectivity Filter of a Voltage-Gated Sodium Channel Biophysical Journal. 108: 490a. DOI: 10.1016/J.Bpj.2014.11.2681  0.587
2014 DeCaen PG, Takahashi Y, Krulwich TA, Ito M, Clapham DE. Ionic selectivity and thermal adaptations within the voltage-gated sodium channel family of alkaliphilic Bacillus. Elife. 3. PMID 25385530 DOI: 10.7554/Elife.04387  0.579
2014 Bagnéris C, DeCaen PG, Naylor CE, Pryde DC, Nobeli I, Clapham DE, Wallace BA. Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism. Proceedings of the National Academy of Sciences of the United States of America. 111: 8428-33. PMID 24850863 DOI: 10.1073/Pnas.1406855111  0.55
2014 DeCaen PG, Takahashi Y, Krulwich TA, Ito M, Clapham DE. Author response: Ionic selectivity and thermal adaptations within the voltage-gated sodium channel family of alkaliphilic Bacillus Elife. DOI: 10.7554/Elife.04387.019  0.494
2014 DeCaen PG, Delling M, Vien TN, Clapham DE. Corrigendum: Direct recording and molecular identification of the calcium channel of primary cilia Nature. 513: 266. DOI: 10.1038/Nature13631  0.473
2014 Bagnéris C, Naylor CE, DeCaen PG, Clapham DE, Pryde D, Wallace B. Structure/Function Insights into Eukaryotic Channel Blocker Binding Sites in a Prokaryotic Sodium Channel Biophysical Journal. 106: 36a. DOI: 10.1016/J.Bpj.2013.11.273  0.542
2013 DeCaen PG, Delling M, Vien TN, Clapham DE. Direct recording and molecular identification of the calcium channel of primary cilia. Nature. 504: 315-8. PMID 24336289 DOI: 10.1038/Nature12832  0.514
2013 Delling M, DeCaen PG, Doerner JF, Febvay S, Clapham DE. Primary cilia are specialized calcium signalling organelles. Nature. 504: 311-4. PMID 24336288 DOI: 10.1038/Nature12833  0.4
2013 Bagnéris C, Decaen PG, Hall BA, Naylor CE, Clapham DE, Kay CW, Wallace BA. Role of the C-terminal domain in the structure and function of tetrameric sodium channels. Nature Communications. 4: 2465. PMID 24051986 DOI: 10.1038/Ncomms3465  0.53
2013 Ulmschneider MB, Bagnéris C, McCusker EC, Decaen PG, Delling M, Clapham DE, Ulmschneider JP, Wallace BA. Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel. Proceedings of the National Academy of Sciences of the United States of America. 110: 6364-9. PMID 23542377 DOI: 10.1073/Pnas.1214667110  0.616
2013 Zhang X, Xia M, Li Y, Liu H, Jiang X, Ren W, Wu J, DeCaen P, Yu F, Huang S, He J, Clapham DE, Yan N, Gong H. Analysis of the selectivity filter of the voltage-gated sodium channel Na(v)Rh. Cell Research. 23: 409-22. PMID 23247626 DOI: 10.1038/Cr.2012.173  0.607
2012 Zhang X, Ren W, DeCaen P, Yan C, Tao X, Tang L, Wang J, Hasegawa K, Kumasaka T, He J, Wang J, Clapham DE, Yan N. Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel. Nature. 486: 130-4. PMID 22678295 DOI: 10.1038/Nature11054  0.58
2012 Yarov-Yarovoy V, DeCaen PG, Westenbroek RE, Pan CY, Scheuer T, Baker D, Catterall WA. Structural basis for gating charge movement in the voltage sensor of a sodium channel. Proceedings of the National Academy of Sciences of the United States of America. 109: E93-102. PMID 22160714 DOI: 10.1073/Pnas.1118434109  0.677
2011 DeCaen PG, Yarov-Yarovoy V, Scheuer T, Catterall WA. Gating charge interactions with the S1 segment during activation of a Na+ channel voltage sensor. Proceedings of the National Academy of Sciences of the United States of America. 108: 18825-30. PMID 22042870 DOI: 10.1073/Pnas.1116449108  0.676
2011 DeCaen PG, Yarov-Yarovoy V, Scheuer T, Catterall WA. Disulfide Locking Reveals Interaction of the Gating Charges with a Negative Charge in the S1 Segment During Activation of the NaChBac Voltage Sensor Biophysical Journal. 100: 422a. DOI: 10.1016/J.Bpj.2010.12.2500  0.668
2011 Yarov-Yarovoy VM, DeCaen P, Scheuer T, Baker D, Catterall WA. High-Resolution Structural Modeling of Voltage-Dependent Conformational Changes in the Voltage Sensor of NaChBac Biophysical Journal. 100: 422a. DOI: 10.1016/J.Bpj.2010.12.2499  0.672
2010 DeCaen PG, Pan CY, Yarov-Yarovoy V, Scheuer T, Catterall WA. Disulfide Locking Reveals a Closed State Interaction Within the Voltage Sensor of NaChBac Biophysical Journal. 98: 112a. DOI: 10.1016/J.Bpj.2009.12.4201  0.668
2009 DeCaen PG, Yarov-Yarovoy V, Sharp EM, Scheuer T, Catterall WA. Sequential formation of ion pairs during activation of a sodium channel voltage sensor. Proceedings of the National Academy of Sciences of the United States of America. 106: 22498-503. PMID 20007787 DOI: 10.1073/Pnas.0912307106  0.671
2009 Yarov-Yarovoy VM, DeCaen P, Scheuer T, Catterall WA. Structural Modeling of Intermediate States of the Gating Pore of NaChBac Biophysical Journal. 96: 253a. DOI: 10.1016/J.Bpj.2008.12.1250  0.676
2009 DeCaen PG, Scheuer T, Catterall WA. Ion Pair Formation During Activation of the NaChBac Voltage Sensor Biophysical Journal. 96: 253a. DOI: 10.1016/J.Bpj.2008.12.1249  0.655
2008 DeCaen PG, Yarov-Yarovoy V, Zhao Y, Scheuer T, Catterall WA. Disulfide locking a sodium channel voltage sensor reveals ion pair formation during activation. Proceedings of the National Academy of Sciences of the United States of America. 105: 15142-7. PMID 18809926 DOI: 10.1073/Pnas.0806486105  0.717
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