Clive N. Svendsen - Publications

Affiliations: 
Waisman Center, University of Wisconsin, Madison, WI, United States 
Area:
Neural Stem Cell biology
Website:
http://www.waisman.wisc.edu/faculty/svendsen.html

174 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Baxi EG, Thompson T, Li J, Kaye JA, Lim RG, Wu J, Ramamoorthy D, Lima L, Vaibhav V, Matlock A, Frank A, Coyne AN, Landin B, Ornelas L, Mosmiller E, ... ... Svendsen CN, et al. Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines. Nature Neuroscience. 25: 226-237. PMID 35115730 DOI: 10.1038/s41593-021-01006-0  0.712
2021 Yucer N, Ahdoot R, Workman MJ, Laperle AH, Recouvreux MS, Kurowski K, Naboulsi DJ, Liang V, Qu Y, Plummer JT, Gayther SA, Orsulic S, Karlan BY, Svendsen CN. Human iPSC-derived fallopian tube organoids with BRCA1 mutation recapitulate early-stage carcinogenesis. Cell Reports. 37: 110146. PMID 34965417 DOI: 10.1016/j.celrep.2021.110146  0.798
2021 Li J, Lim RG, Kaye JA, Dardov V, Coyne AN, Wu J, Milani P, Cheng A, Thompson TG, Ornelas L, Frank A, Adam M, Banuelos MG, Casale M, ... ... Svendsen CN, et al. An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients. Iscience. 24: 103221. PMID 34746695 DOI: 10.1016/j.isci.2021.103221  0.817
2021 Barker RA, Björklund A, Frucht SJ, Svendsen CN. Stem Cell-Derived Dopamine Neurons: Will They Replace DBS as the Leading Neurosurgical Treatment for Parkinson's Disease? Journal of Parkinson's Disease. 11: 909-917. PMID 34334425 DOI: 10.3233/JPD-219008  0.523
2021 Vatine GD, Shelest O, Barriga BK, Ofan R, Rabinski T, Mattis VB, Heuer H, Svendsen CN. Oligodendrocyte progenitor cell maturation is dependent on dual function of MCT8 in the transport of thyroid hormone across brain barriers and the plasma membrane. Glia. PMID 33956384 DOI: 10.1002/glia.24014  0.725
2020 Workman MJ, Troisi E, Targan SR, Svendsen CN, Barrett RJ. Modeling Intestinal Epithelial Response to Interferon-γ in Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids. International Journal of Molecular Sciences. 22. PMID 33396621 DOI: 10.3390/ijms22010288  0.723
2020 Ho R, Workman MJ, Mathkar P, Wu K, Kim KJ, O'Rourke JG, Kellogg M, Montel V, Banuelos MG, Arogundade OA, Diaz-Garcia S, Oheb D, Huang S, Khrebtukova I, Watson L, ... ... Svendsen CN, et al. Cross-Comparison of Human iPSC Motor Neuron Models of Familial and Sporadic ALS Reveals Early and Convergent Transcriptomic Disease Signatures. Cell Systems. PMID 33382996 DOI: 10.1016/j.cels.2020.10.010  0.796
2020 Coyne AN, Zaepfel BL, Hayes L, Fitchman B, Salzberg Y, Luo EC, Bowen K, Trost H, Aigner S, Rigo F, Yeo GW, Harel A, Svendsen CN, Sareen D, Rothstein JD. GC Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD. Neuron. PMID 32673563 DOI: 10.1016/J.Neuron.2020.06.027  0.413
2020 Das Sharma S, Pal R, Reddy BK, Selvaraj BT, Raj N, Samaga KK, Srinivasan DJ, Ornelas L, Sareen D, Livesey MR, Bassell GJ, Svendsen CN, Kind PC, Chandran S, Chattarji S, et al. Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns. Molecular Autism. 11: 52. PMID 32560741 DOI: 10.1186/S13229-020-00351-4  0.454
2020 Zhao W, Beers DR, Thonhoff JR, Thome AD, Faridar A, Wang J, Wen S, Ornelas L, Sareen D, Goodridge HS, Svendsen CN, Appel SH. Immunosuppressive Functions of M2 Macrophages Derived from iPSCs of Patients with ALS and Healthy Controls. Iscience. 23: 101192. PMID 32521508 DOI: 10.1016/J.Isci.2020.101192  0.351
2020 Toombs J, Panther L, Ornelas L, Liu C, Gomez E, Martín-Ibáñez R, Cox SR, Ritchie SJ, Harris SE, Taylor A, Redmond P, Russ TC, Murphy L, Cooper JD, Burr K, ... ... Svendsen CN, et al. Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian Birth Cohort 1936. Stem Cell Research. 46: 101851. PMID 32450543 DOI: 10.1016/J.Scr.2020.101851  0.366
2020 Jagadeesan S, Workman MJ, Herland A, Svendsen CN, Vatine GD. Generation of a Human iPSC-Based Blood-Brain Barrier Chip. Journal of Visualized Experiments : Jove. PMID 32176199 DOI: 10.3791/60925  0.431
2020 Gleeson JP, Estrada HQ, Yamashita M, Svendsen CN, Targan SR, Barrett RJ. Development of Physiologically Responsive Human iPSC-Derived Intestinal Epithelium to Study Barrier Dysfunction in IBD. International Journal of Molecular Sciences. 21. PMID 32093254 DOI: 10.3390/Ijms21041438  0.807
2020 Laperle AH, Sances S, Yucer N, Dardov VJ, Garcia VJ, Ho R, Fulton AN, Jones MR, Roxas KM, Avalos P, West D, Banuelos MG, Shu Z, Murali R, Maidment NT, ... ... Svendsen CN, et al. iPSC modeling of young-onset Parkinson's disease reveals a molecular signature of disease and novel therapeutic candidates. Nature Medicine. PMID 31988461 DOI: 10.1038/S41591-019-0739-1  0.777
2019 Garcia VJ, Rushton DJ, Tom CM, Allen ND, Kemp PJ, Svendsen CN, Mattis VB. Huntington's Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support. Frontiers in Neuroscience. 13: 669. PMID 31316341 DOI: 10.3389/Fnins.2019.00669  0.827
2019 Vatine GD, Barrile R, Workman MJ, Sances S, Barriga BK, Rahnama M, Barthakur S, Kasendra M, Lucchesi C, Kerns J, Wen N, Spivia WR, Chen Z, Van Eyk J, Svendsen CN. Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications. Cell Stem Cell. 24: 995-1005.e6. PMID 31173718 DOI: 10.1016/j.stem.2019.05.011  0.581
2019 Kedaigle AJ, Fraenkel E, Atwal RS, Wu M, Gusella JF, MacDonald ME, Kaye JA, Finkbeiner S, Mattis VB, Tom CM, Svendsen C, King AR, Chen Y, Stocksdale JT, Lim RG, et al. Bioenergetic deficits in Huntington's disease iPSC-derived neural cells and rescue with glycolytic metabolites. Human Molecular Genetics. PMID 30768179 DOI: 10.1093/Hmg/Ddy430  0.761
2019 Gleeson JP, Rabizadeh S, Estrada HQ, Li D, McGovern D, Svendsen C, Targan SR, Barrett RJ. Sa1096 – A Personalized Model to Assess Intestinal Permeability in IBD and Veoibd Patients Using Human Ipsc-Derived Intestinal and Colonic Organoids Gastroenterology. 156: S-269-S-270. DOI: 10.1016/S0016-5085(19)37479-7  0.778
2018 Jones MK, Lu B, Chen DZ, Spivia WR, Mercedo A, Ljubimov AV, Svendsen CN, Van Eyk JE, Wang S. In vitro and in vivo Proteomic Comparison of Human Neural Progenitor Cell-Induced Photoreceptor Survival. Proteomics. e1800213. PMID 30515959 DOI: 10.1002/pmic.201800213  0.546
2018 Keisham B, Seksenyan A, Denyer S, Kheirkhah P, Arnone GD, Avalos P, Bhimani AD, Svendsen C, Berry V, Mehta A. Quantum Capacitance Based Amplified Graphene Phononics for Studying Neurodegenerative Diseases. Acs Applied Materials & Interfaces. PMID 30468382 DOI: 10.1021/Acsami.8B15893  0.367
2018 Abbot S, Agbanyo F, Ahlfors JE, Baghbaderani BA, Bartido S, Bharti K, Burke C, Carlsson B, Cavagnaro J, Creasey A, DiGiusto D, Francissen K, Gaffney A, Goldring C, Gorba T, ... ... Svendsen CN, et al. Report of the international conference on manufacturing and testing of pluripotent stem cells. Biologicals : Journal of the International Association of Biological Standardization. PMID 30150108 DOI: 10.1016/J.Biologicals.2018.08.004  0.369
2018 Baloh RH, Glass JD, Svendsen CN. Stem cell transplantation for amyotrophic lateral sclerosis. Current Opinion in Neurology. PMID 30080719 DOI: 10.1097/WCO.0000000000000598  0.415
2018 Workman MJ, Gleeson JP, Troisi EJ, Estrada HQ, Kerns SJ, Hinojosa CD, Hamilton GA, Targan SR, Svendsen CN, Barrett RJ. Enhanced Utilization of Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids Using Microengineered Chips. Cellular and Molecular Gastroenterology and Hepatology. 5: 669-677.e2. PMID 29930984 DOI: 10.1016/J.Jcmgh.2017.12.008  0.819
2018 Akhtar AA, Gowing G, Kobritz N, Savinoff SE, Garcia L, Saxon D, Cho N, Kim G, Tom CM, Park H, Lawless G, Shelley BC, Mattis VB, Breunig JJ, Svendsen CN. Inducible Expression of GDNF in Transplanted iPSC-Derived Neural Progenitor Cells. Stem Cell Reports. PMID 29706501 DOI: 10.1016/J.Stemcr.2018.03.024  0.827
2018 Thomsen GM, Avalos P, Ma AA, Alkaslasi M, Cho N, Wyss L, Vit JP, Godoy M, Suezaki P, Shelest O, Bankiewicz KS, Svendsen CN. Transplantation of Neural Progenitor Cells Expressing Glial Cell Line-Derived Neurotrophic Factor into the Motor Cortex as a Strategy to Treat Amyotrophic Lateral Sclerosis. Stem Cells (Dayton, Ohio). PMID 29656478 DOI: 10.1002/Stem.2825  0.783
2018 Sances S, Ho R, Vatine G, West D, Laperle A, Meyer A, Godoy M, Kay PS, Mandefro B, Hatata S, Hinojosa C, Wen N, Sareen D, Hamilton GA, Svendsen CN. Human iPSC-Derived Endothelial Cells and Microengineered Organ-Chip Enhance Neuronal Development. Stem Cell Reports. PMID 29576540 DOI: 10.1016/J.Stemcr.2018.02.012  0.819
2018 Nicolas A, Kenna KP, Renton AE, Ticozzi N, Faghri F, Chia R, Dominov JA, Kenna BJ, Nalls MA, Keagle P, Rivera AM, van Rheenen W, Murphy NA, van Vugt JJFA, Geiger JT, ... ... Svendsen CN, et al. Genome-wide Analyses Identify KIF5A as a Novel ALS Gene. Neuron. 97: 1268-1283.e6. PMID 29566793 DOI: 10.1016/J.Neuron.2018.02.027  0.657
2018 Mattis VB, Svendsen CN. Huntington modeling improves with age. Nature Neuroscience. PMID 29476127 DOI: 10.1038/s41593-018-0086-4  0.734
2018 Conforti P, Besusso D, Bocchi VD, Faedo A, Cesana E, Rossetti G, Ranzani V, Svendsen CN, Thompson LM, Toselli M, Biella G, Pagani M, Cattaneo E. Faulty neuronal determination and cell polarization are reverted by modulating HD early phenotypes. Proceedings of the National Academy of Sciences of the United States of America. PMID 29311338 DOI: 10.1073/Pnas.1715865115  0.464
2018 Keenan AB, Jenkins SL, Jagodnik KM, Koplev S, He E, Torre D, Wang Z, Dohlman AB, Silverstein MC, Lachmann A, Kuleshov MV, Ma'ayan A, Stathias V, Terryn R, Cooper D, ... ... Svendsen CN, et al. The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations. Cell Systems. 6: 13-24. PMID 29199020 DOI: 10.1016/J.Cels.2017.11.001  0.781
2017 Yucer N, Holzapfel M, Jenkins Vogel T, Lenaeus L, Ornelas L, Laury A, Sareen D, Barrett R, Karlan BY, Svendsen CN. Directed Differentiation of Human Induced Pluripotent Stem Cells into Fallopian Tube Epithelium. Scientific Reports. 7: 10741. PMID 28878359 DOI: 10.1038/S41598-017-05519-2  0.809
2017 Saghizadeh M, Kramerov AA, Svendsen CN, Ljubimov AV. Concise Review: Stem Cells for Corneal Wound Healing. Stem Cells (Dayton, Ohio). PMID 28748596 DOI: 10.1002/Stem.2667  0.416
2017 Vatine GD, Al-Ahmad A, Barriga BK, Svendsen S, Salim A, Garcia L, Garcia VJ, Ho R, Yucer N, Qian T, Lim RG, Wu J, Thompson LM, Spivia WR, Chen Z, ... ... Svendsen CN, et al. Modeling Psychomotor Retardation using iPSCs from MCT8-Deficient Patients Indicates a Prominent Role for the Blood-Brain Barrier. Cell Stem Cell. PMID 28526555 DOI: 10.1016/J.Stem.2017.04.002  0.787
2017 Lim RG, Quan C, Reyes-Ortiz AM, Lutz SE, Kedaigle AJ, Gipson TA, Wu J, Vatine GD, Stocksdale J, Casale MS, Svendsen CN, Fraenkel E, Housman DE, Agalliu D, Thompson LM. Huntington's Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits. Cell Reports. 19: 1365-1377. PMID 28514657 DOI: 10.1016/J.Celrep.2017.04.021  0.421
2017 Thomsen GM, Alkaslasi M, Vit JP, Lawless G, Godoy M, Gowing G, Shelest O, Svendsen CN. Systemic injection of AAV9-GDNF provides modest functional improvements in the SOD1 ALS rat but has adverse side effects. Gene Therapy. 24: 245-252. PMID 28276446 DOI: 10.1038/gt.2017.9  0.743
2017 Goldberg NR, Marsh SE, Ochaba J, Shelley BC, Davtyan H, Thompson LM, Steffan JS, Svendsen CN, Blurton-Jones M. Human Neural Progenitor Transplantation Rescues Behavior and Reduces α-Synuclein in a Transgenic Model of Dementia with Lewy Bodies. Stem Cells Translational Medicine. PMID 28225193 DOI: 10.1002/Sctm.16-0362  0.425
2017 Lamanna JJ, Gutierrez J, Urquia LN, Hurtig CV, Amador E, Grin N, Svendsen CN, Federici T, Oshinski JN, Boulis NM. Ferumoxytol Labeling of Human Neural Progenitor Cells for Diagnostic Cellular Tracking in the Porcine Spinal Cord with Magnetic Resonance Imaging. Stem Cells Translational Medicine. 6: 139-150. PMID 28170192 DOI: 10.5966/Sctm.2015-0422  0.356
2017 Workman M, Troisi E, Kerns SJ, Hamilton GA, Svendsen C, Targan SR, Barrett RJ. Intestine-Chip: A New Model to Understand the Role of the Intestinal Epithelium in IBD by Combining Microengineering Technology and IPSC-Derived Human Intestinal Organoids Gastroenterology. 152: S57-S58. DOI: 10.1016/S0016-5085(17)30550-4  0.708
2016 Canfield SG, Stebbins MJ, Morales BS, Asai SW, Vatine GD, Svendsen CN, Palecek SP, Shusta EV. An Isogenic Blood-Brain Barrier Model Comprising Brain Endothelial Cells, Astrocytes and Neurons Derived from Human Induced Pluripotent Stem Cells. Journal of Neurochemistry. PMID 27935037 DOI: 10.1111/Jnc.13923  0.471
2016 Thomsen GM, Ma A, Ko A, Harada MY, Wyss L, Haro P, Vit JP, Shelest O, Rhee P, Svendsen CN, Ley EJ. A model of recurrent concussion that leads to long-term motor deficits, CTE-like tauopathy and exacerbation of an ALS phenotype. The Journal of Trauma and Acute Care Surgery. PMID 27602892 DOI: 10.1097/Ta.0000000000001248  0.74
2016 Qu Y, Zhou B, Yang W, Han B, Yu-Rice Y, Gao B, Johnson J, Svendsen CN, Freeman MR, Giuliano AE, Sareen D, Cui X. Transcriptome and proteome characterization of surface ectoderm cells differentiated from human iPSCs. Scientific Reports. 6: 32007. PMID 27550649 DOI: 10.1038/Srep32007  0.453
2016 Ho R, Sances S, Gowing G, Amoroso MW, O'Rourke JG, Sahabian A, Wichterle H, Baloh RH, Sareen D, Svendsen CN. ALS disrupts spinal motor neuron maturation and aging pathways within gene co-expression networks. Nature Neuroscience. PMID 27428653 DOI: 10.1038/Nn.4345  0.791
2016 Milani P, Escalante-Chong R, Shelley BC, Patel-Murray NL, Xin X, Adam M, Mandefro B, Sareen D, Svendsen CN, Fraenkel E. Cell freezing protocol suitable for ATAC-Seq on motor neurons derived from human induced pluripotent stem cells. Scientific Reports. 6: 25474. PMID 27146274 DOI: 10.1038/Srep25474  0.488
2016 Das MM, Avalos P, Suezaki P, Godoy M, Garcia L, Chang CD, Vit JP, Shelley B, Gowing G, Svendsen CN. Human neural progenitors differentiate into astrocytes and protect motor neurons in aging rats. Experimental Neurology. PMID 27032721 DOI: 10.1016/j.expneurol.2016.03.023  0.389
2016 Sances S, Bruijn LI, Chandran S, Eggan K, Ho R, Klim JR, Livesey MR, Lowry E, Macklis JD, Rushton D, Sadegh C, Sareen D, Wichterle H, Zhang SC, Svendsen CN. Modeling ALS with motor neurons derived from human induced pluripotent stem cells. Nature Neuroscience. 16: 542-53. PMID 27021939 DOI: 10.1038/nn.4273  0.797
2016 Hjelm BE, Grunseich C, Gowing G, Avalos P, Tian J, Shelley BC, Mooney M, Narwani K, Shi Y, Svendsen CN, Wolfe JH, Fischbeck KH, Pierson TM. Mifepristone-inducible transgene expression in neural progenitor cells in vitro and in vivo. Gene Therapy. PMID 26863047 DOI: 10.1038/Gt.2016.13  0.413
2016 Suzuki M, Svendsen CN. Ex Vivo Gene Therapy Using Human Mesenchymal Stem Cells to Deliver Growth Factors in the Skeletal Muscle of a Familial ALS Rat Model. Methods in Molecular Biology (Clifton, N.J.). 1382: 325-36. PMID 26611598 DOI: 10.1007/978-1-4939-3271-9_24  0.41
2015 Bakondi B, Lv W, Lu B, Jones MK, Tsai Y, Kim KJ, Levy R, Akhtar AA, Breunig JJ, Svendsen CN, Wang S. In Vivo CRISPR/Cas9 Gene Editing Corrects Retinal Dystrophy in the S334ter-3 Rat Model of Autosomal Dominant Retinitis Pigmentosa. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 26666451 DOI: 10.1038/Mt.2015.220  0.72
2015 Thomsen GM, Vit JP, Lamb A, Gowing G, Shelest O, Alkaslasi M, Ley EJ, Svendsen CN. Acute Traumatic Brain Injury Does Not Exacerbate Amyotrophic Lateral Sclerosis in the SOD1 (G93A) Rat Model(1,2,3). Eneuro. 2. PMID 26464984 DOI: 10.1523/ENEURO.0059-14.2015  0.732
2015 Mattis VB, Svendsen CN. Modeling Huntington׳s disease with patient-derived neurons. Brain Research. PMID 26459990 DOI: 10.1016/j.brainres.2015.10.001  0.801
2015 Straccia M, Garcia-Diaz Barriga G, Sanders P, Bombau G, Carrere J, Mairal PB, Vinh NN, Yung S, Kelly CM, Svendsen CN, Kemp PJ, Arjomand J, Schoenfeld RC, Alberch J, Allen ND, et al. Quantitative high-throughput gene expression profiling of human striatal development to screen stem cell-derived medium spiny neurons. Molecular Therapy. Methods & Clinical Development. 2: 15030. PMID 26417608 DOI: 10.1038/Mtm.2015.30  0.467
2015 Levy M, Boulis N, Rao M, Svendsen CN. Regenerative cellular therapies for neurologic diseases. Brain Research. PMID 26239912 DOI: 10.1016/J.Brainres.2015.06.053  0.45
2015 Hatada S, Subramanian A, Mandefro B, Ren S, Kim HW, Tang J, Funari V, Baloh RH, Sareen D, Arumugaswami V, Svendsen CN. Low-Dose Irradiation Enhances Gene Targeting in Human Pluripotent Stem Cells. Stem Cells Translational Medicine. PMID 26185257 DOI: 10.5966/Sctm.2015-0050  0.402
2015 Bernau K, Lewis CM, Petelinsek AM, Reagan MS, Niles DJ, Mattis VB, Meyerand ME, Suzuki M, Svendsen CN. In Vivo Tracking of Human Neural Progenitor Cells in the Rat Brain Using Magnetic Resonance Imaging is Not Enhanced by Ferritin Expression. Cell Transplantation. PMID 26160767 DOI: 10.3727/096368915X688614  0.737
2015 Gutierrez J, Lamanna JJ, Grin N, Hurtig CV, Miller JH, Riley J, Urquia L, Avalos P, Svendsen CN, Federici T, Boulis NM. Preclinical Validation of Multilevel Intraparenchymal Stem Cell Therapy in the Porcine Spinal Cord. Neurosurgery. 77: 604-12. PMID 26134596 DOI: 10.1227/Neu.0000000000000882  0.353
2015 Tsai Y, Lu B, Bakondi B, Girman S, Sahabian A, Sareen D, Svendsen CN, Wang S. Human iPSC-Derived Neural Progenitors Preserve Vision in an AMD-Like Model. Stem Cells (Dayton, Ohio). PMID 25869002 DOI: 10.1002/Stem.2032  0.397
2015 Mattis VB, Tom C, Akimov S, Saeedian J, Østergaard ME, Southwell AL, Doty CN, Ornelas L, Sahabian A, Lenaeus L, Mandefro B, Sareen D, Arjomand J, Hayden MR, Ross CA, ... Svendsen CN, et al. HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity. Human Molecular Genetics. 24: 3257-71. PMID 25740845 DOI: 10.1093/Hmg/Ddv080  0.769
2015 Kong SY, Park MH, Lee M, Kim JO, Lee HR, Han BW, Svendsen CN, Sung SH, Kim HJ. Kuwanon V inhibits proliferation, promotes cell survival and increases neurogenesis of neural stem cells. Plos One. 10: e0118188. PMID 25706719 DOI: 10.1371/journal.pone.0118188  0.438
2015 Das MM, Svendsen CN. Astrocytes show reduced support of motor neurons with aging that is accelerated in a rodent model of ALS. Neurobiology of Aging. 36: 1130-9. PMID 25443290 DOI: 10.1016/j.neurobiolaging.2014.09.020  0.395
2014 Lu XH, Mattis VB, Wang N, Al-Ramahi I, van den Berg N, Fratantoni SA, Waldvogel H, Greiner E, Osmand A, Elzein K, Xiao J, Dijkstra S, de Pril R, Vinters HV, Faull R, ... ... Svendsen CN, et al. Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease. Science Translational Medicine. 6: 268ra178. PMID 25540325 DOI: 10.1126/Scitranslmed.3010523  0.764
2014 Thomsen GM, Gowing G, Latter J, Chen M, Vit JP, Staggenborg K, Avalos P, Alkaslasi M, Ferraiuolo L, Likhite S, Kaspar BK, Svendsen CN. Delayed disease onset and extended survival in the SOD1G93A rat model of amyotrophic lateral sclerosis after suppression of mutant SOD1 in the motor cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 15587-600. PMID 25411487 DOI: 10.1523/Jneurosci.2037-14.2014  0.765
2014 Barrett R, Ornelas L, Yeager N, Mandefro B, Sahabian A, Lenaeus L, Targan SR, Svendsen CN, Sareen D. Reliable generation of induced pluripotent stem cells from human lymphoblastoid cell lines. Stem Cells Translational Medicine. 3: 1429-34. PMID 25298370 DOI: 10.5966/Sctm.2014-0121  0.795
2014 Rosser A, Svendsen CN. Stem cells for cell replacement therapy: a therapeutic strategy for HD? Movement Disorders : Official Journal of the Movement Disorder Society. 29: 1446-54. PMID 25216372 DOI: 10.1002/Mds.26026  0.505
2014 Sareen D, Saghizadeh M, Ornelas L, Winkler MA, Narwani K, Sahabian A, Funari VA, Tang J, Spurka L, Punj V, Maguen E, Rabinowitz YS, Svendsen CN, Ljubimov AV. Differentiation of human limbal-derived induced pluripotent stem cells into limbal-like epithelium. Stem Cells Translational Medicine. 3: 1002-12. PMID 25069777 DOI: 10.5966/Sctm.2014-0076  0.435
2014 Bernau K, Lewis CM, Petelinsek AM, Benink HA, Zimprich CA, Meyerand ME, Suzuki M, Svendsen CN. In vivo tracking of human neural progenitor cells in the rat brain using bioluminescence imaging. Journal of Neuroscience Methods. 228: 67-78. PMID 24675049 DOI: 10.1016/J.Jneumeth.2014.03.005  0.408
2014 Thomsen GM, Gowing G, Svendsen S, Svendsen CN. The past, present and future of stem cell clinical trials for ALS. Experimental Neurology. 262: 127-37. PMID 24613827 DOI: 10.1016/J.Expneurol.2014.02.021  0.79
2014 Sareen D, Gowing G, Sahabian A, Staggenborg K, Paradis R, Avalos P, Latter J, Ornelas L, Garcia L, Svendsen CN. Human induced pluripotent stem cells are a novel source of neural progenitor cells (iNPCs) that migrate and integrate in the rodent spinal cord. The Journal of Comparative Neurology. 522: 2707-28. PMID 24610630 DOI: 10.1002/Cne.23578  0.47
2014 Mattis VB, Wakeman DR, Tom C, Dodiya HB, Yeung SY, Tran AH, Bernau K, Ornelas L, Sahabian A, Reidling J, Sareen D, Thompson LM, Kordower JH, Svendsen CN. Neonatal immune-tolerance in mice does not prevent xenograft rejection. Experimental Neurology. 254: 90-8. PMID 24440640 DOI: 10.1016/J.Expneurol.2014.01.007  0.741
2014 Tsai Y, Lu B, Ljubimov AV, Girman S, Ross-Cisneros FN, Sadun AA, Svendsen CN, Cohen RM, Wang S. Ocular changes in TgF344-AD rat model of Alzheimer's disease. Investigative Ophthalmology & Visual Science. 55: 523-34. PMID 24398104 DOI: 10.1167/iovs.13-12888  0.307
2014 Barrett R, Yeager N, Rushton D, Ornelas L, Sareen D, Svendsen C, Targan S. Su1989 Generation of Functional Human Intestinal Organoids From Lymphoblastoid B-Cell Lines: Opportunity for Gene Specific Functional Assessment in IBD Gastroenterology. 146: S-516. DOI: 10.1016/S0016-5085(14)61868-0  0.745
2013 Rushton DJ, Mattis VB, Svendsen CN, Allen ND, Kemp PJ. Stimulation of GABA-induced Ca2+ influx enhances maturation of human induced pluripotent stem cell-derived neurons. Plos One. 8: e81031. PMID 24278369 DOI: 10.1371/journal.pone.0081031  0.753
2013 Saghizadeh M, Winkler MA, Kramerov AA, Hemmati DM, Ghiam CA, Dimitrijevich SD, Sareen D, Ornelas L, Ghiasi H, Brunken WJ, Maguen E, Rabinowitz YS, Svendsen CN, Jirsova K, Ljubimov AV. A simple alkaline method for decellularizing human amniotic membrane for cell culture. Plos One. 8: e79632. PMID 24236148 DOI: 10.1371/Journal.Pone.0079632  0.344
2013 Sareen D, O'Rourke JG, Meera P, Muhammad AK, Grant S, Simpkinson M, Bell S, Carmona S, Ornelas L, Sahabian A, Gendron T, Petrucelli L, Baughn M, Ravits J, Harms MB, ... ... Svendsen CN, et al. Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion. Science Translational Medicine. 5: 208ra149. PMID 24154603 DOI: 10.1126/Scitranslmed.3007529  0.401
2013 Lu B, Morgans CW, Girman S, Luo J, Zhao J, Du H, Lim S, Ding S, Svendsen C, Zhang K, Wang S. Neural Stem Cells Derived by Small Molecules Preserve Vision. Translational Vision Science & Technology. 2: 1. PMID 24049711 DOI: 10.1167/Tvst.2.1.1  0.451
2013 Krakora D, Mulcrone P, Meyer M, Lewis C, Bernau K, Gowing G, Zimprich C, Aebischer P, Svendsen CN, Suzuki M. Synergistic effects of GDNF and VEGF on lifespan and disease progression in a familial ALS rat model. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 1602-10. PMID 23712039 DOI: 10.1038/Mt.2013.108  0.421
2013 Ebert AD, Shelley BC, Hurley AM, Onorati M, Castiglioni V, Patitucci TN, Svendsen SP, Mattis VB, McGivern JV, Schwab AJ, Sareen D, Kim HW, Cattaneo E, Svendsen CN. EZ spheres: a stable and expandable culture system for the generation of pre-rosette multipotent stem cells from human ESCs and iPSCs. Stem Cell Research. 10: 417-27. PMID 23474892 DOI: 10.1016/J.Scr.2013.01.009  0.777
2013 Nichols NL, Gowing G, Satriotomo I, Nashold LJ, Dale EA, Suzuki M, Avalos P, Mulcrone PL, McHugh J, Svendsen CN, Mitchell GS. Intermittent hypoxia and stem cell implants preserve breathing capacity in a rodent model of amyotrophic lateral sclerosis. American Journal of Respiratory and Critical Care Medicine. 187: 535-42. PMID 23220913 DOI: 10.1164/Rccm.201206-1072Oc  0.437
2012 Keenan TM, Grinager JR, Procak AA, Svendsen CN. In vitro localization of human neural stem cell neurogenesis by engineered FGF-2 gradients. Integrative Biology : Quantitative Biosciences From Nano to Macro. 4: 1522-31. PMID 23147909 DOI: 10.1039/c2ib20074k  0.456
2012 Biancotti JC, Narwani K, Mandefro B, Golan-Lev T, Buehler N, Hill D, Svendsen CN, Benvenisty N. The in vitro survival of human monosomies and trisomies as embryonic stem cells. Stem Cell Research. 9: 218-24. PMID 22892439 DOI: 10.1016/J.Scr.2012.07.002  0.383
2012 Breunig JJ, Gate D, Levy R, Rodriguez J, Kim GB, Danielpour M, Svendsen CN, Town T. Rapid genetic targeting of pial surface neural progenitors and immature neurons by neonatal electroporation. Neural Development. 7: 26. PMID 22776033 DOI: 10.1186/1749-8104-7-26  0.677
2012 Sareen D, Ebert AD, Heins BM, McGivern JV, Ornelas L, Svendsen CN. Inhibition of apoptosis blocks human motor neuron cell death in a stem cell model of spinal muscular atrophy. Plos One. 7: e39113. PMID 22723941 DOI: 10.1371/Journal.Pone.0039113  0.45
2012 Hayes-Punzo A, Mulcrone P, Meyer M, McHugh J, Svendsen CN, Suzuki M. Gonadectomy and dehydroepiandrosterone (DHEA) do not modulate disease progression in the G93A mutant SOD1 rat model of amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group On Motor Neuron Diseases. 13: 311-4. PMID 22409357 DOI: 10.3109/17482968.2012.654393  0.339
2012 Lindvall O, Barker RA, Brüstle O, Isacson O, Svendsen CN. Clinical translation of stem cells in neurodegenerative disorders. Cell Stem Cell. 10: 151-5. PMID 22305565 DOI: 10.1016/j.stem.2012.01.009  0.581
2012 Kitiyanant N, Kitiyanant Y, Svendsen CN, Thangnipon W. BDNF-, IGF-1- and GDNF-secreting human neural progenitor cells rescue amyloid β-induced toxicity in cultured rat septal neurons. Neurochemical Research. 37: 143-52. PMID 21909955 DOI: 10.1007/S11064-011-0592-1  0.434
2012 Mattis V, Svendsen S, Ebert A, Svendsen C, King A, Casale M, Winokur S, Batugedara G, Vawter M, Donovan P, Lock L, Thompson L, Zhu Y, Fossale E, Atwal R, et al. A11 Induced pluripotent stem cells for basic and translational research on HD Journal of Neurology, Neurosurgery & Psychiatry. 83: A3.2-A4. DOI: 10.1136/Jnnp-2012-303524.11  0.799
2012 Mattis VB, Svendsen SP, Ebert A, Svendsen CN, King AR, Casale M, Winokur ST, Batugedara G, Vawter M, Donovan PJ, Lock LF, Thompson LM, Zhu Y, Fossale E, Atwal RS, et al. Induced pluripotent stem cells from patients with huntington’s disease show CAG repeat expansion associated phenotypes Cell Stem Cell. 11: 264-278. DOI: 10.1016/J.Stem.2012.04.027  0.785
2011 Lippmann ES, Weidenfeller C, Svendsen CN, Shusta EV. Blood-brain barrier modeling with co-cultured neural progenitor cell-derived astrocytes and neurons. Journal of Neurochemistry. 119: 507-20. PMID 21854389 DOI: 10.1111/J.1471-4159.2011.07434.X  0.427
2011 Andres RH, Horie N, Slikker W, Keren-Gill H, Zhan K, Sun G, Manley NC, Pereira MP, Sheikh LA, McMillan EL, Schaar BT, Svendsen CN, Bliss TM, Steinberg GK. Human neural stem cells enhance structural plasticity and axonal transport in the ischaemic brain. Brain : a Journal of Neurology. 134: 1777-89. PMID 21616972 DOI: 10.1093/Brain/Awr094  0.407
2011 Mattis VB, Svendsen CN. Induced pluripotent stem cells: a new revolution for clinical neurology? The Lancet. Neurology. 10: 383-94. PMID 21435601 DOI: 10.1016/S1474-4422(11)70022-9  0.785
2011 Alexanian AR, Svendsen CN, Crowe MJ, Kurpad SN. Transplantation of human glial-restricted neural precursors into injured spinal cord promotes functional and sensory recovery without causing allodynia. Cytotherapy. 13: 61-8. PMID 20735167 DOI: 10.3109/14653249.2010.510504  0.416
2011 Kitiyanant N, Svendsen CN, Kitiyanant Y, Thangnipon W. Neurotrophic factor-releasing human neural stem/progenitor cells rescue cultured rat septal neurons from amyloid β-induced neurotoxicity Neuroscience Research. 71: e226. DOI: 10.1016/J.Neures.2011.07.987  0.438
2010 Candolfi M, Xiong W, Yagiz K, Liu C, Muhammad AK, Puntel M, Foulad D, Zadmehr A, Ahlzadeh GE, Kroeger KM, Tesarfreund M, Lee S, Debinski W, Sareen D, Svendsen CN, et al. Gene therapy-mediated delivery of targeted cytotoxins for glioma therapeutics. Proceedings of the National Academy of Sciences of the United States of America. 107: 20021-6. PMID 21030678 DOI: 10.1073/Pnas.1008261107  0.512
2010 Keenan TM, Nelson AD, Grinager JR, Thelen JC, Svendsen CN. Real time imaging of human progenitor neurogenesis. Plos One. 5: e13187. PMID 20949053 DOI: 10.1371/journal.pone.0013187  0.49
2010 Sareen D, Svendsen CN. Stem cell biologists sure play a mean pinball. Nature Biotechnology. 28: 333-5. PMID 20379177 DOI: 10.1038/Nbt0410-333  0.441
2010 Ebert AD, Barber AE, Heins BM, Svendsen CN. Ex vivo delivery of GDNF maintains motor function and prevents neuronal loss in a transgenic mouse model of Huntington's disease. Experimental Neurology. 224: 155-62. PMID 20227407 DOI: 10.1016/J.Expneurol.2010.03.005  0.448
2010 Suzuki M, Klein S, Wetzel EA, Meyer M, McHugh J, Tork C, Hayes A, Svendsen CN. Acute glial activation by stab injuries does not lead to overt damage or motor neuron degeneration in the G93A mutant SOD1 rat model of amyotrophic lateral sclerosis. Experimental Neurology. 221: 346-52. PMID 20005223 DOI: 10.1016/J.Expneurol.2009.12.004  0.348
2010 Sareen D, Svendsen C. 161 HUMAN ES AND IPS CELL DIFFERENTIATION TO NEURAL PHENOTYPES Reproductive Biomedicine Online. 20: S70-S71. DOI: 10.1016/S1472-6483(10)62579-5  0.318
2010 Sareen D, Svendsen C. 160 DISEASE MODELING USING HUMAN IPS CELLS Reproductive Biomedicine Online. 20: S70. DOI: 10.1016/S1472-6483(10)62578-3  0.307
2009 Sareen D, McMillan E, Ebert AD, Shelley BC, Johnson JA, Meisner LF, Svendsen CN. Chromosome 7 and 19 trisomy in cultured human neural progenitor cells. Plos One. 4: e7630. PMID 19898616 DOI: 10.1371/Journal.Pone.0007630  0.406
2009 Bhattacharyya A, McMillan E, Chen SI, Wallace K, Svendsen CN. A critical period in cortical interneuron neurogenesis in down syndrome revealed by human neural progenitor cells. Developmental Neuroscience. 31: 497-510. PMID 19738365 DOI: 10.1159/000236899  0.443
2009 Ebert AD, Yu J, Rose FF, Mattis VB, Lorson CL, Thomson JA, Svendsen CN. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature. 457: 277-80. PMID 19098894 DOI: 10.1038/Nature07677  0.825
2009 Kim HJ, McMillan E, Han F, Svendsen CN. Regionally specified human neural progenitor cells derived from the mesencephalon and forebrain undergo increased neurogenesis following overexpression of ASCL1. Stem Cells (Dayton, Ohio). 27: 390-8. PMID 19008346 DOI: 10.1634/stemcells.2007-1047  0.457
2008 Behrstock S, Ebert AD, Klein S, Schmitt M, Moore JM, Svendsen CN. Lesion-induced increase in survival and migration of human neural progenitor cells releasing GDNF. Cell Transplantation. 17: 753-62. PMID 19044202 DOI: 10.3727/096368908786516819  0.426
2008 Gamm DM, Wright LS, Capowski EE, Shearer RL, Meyer JS, Kim HJ, Schneider BL, Melvan JN, Svendsen CN. Regulation of prenatal human retinal neurosphere growth and cell fate potential by retinal pigment epithelium and Mash1. Stem Cells (Dayton, Ohio). 26: 3182-93. PMID 18802035 DOI: 10.1634/Stemcells.2008-0300  0.411
2008 Suzuki M, McHugh J, Tork C, Shelley B, Hayes A, Bellantuono I, Aebischer P, Svendsen CN. Direct muscle delivery of GDNF with human mesenchymal stem cells improves motor neuron survival and function in a rat model of familial ALS. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 2002-10. PMID 18797452 DOI: 10.1038/Mt.2008.197  0.442
2008 Wang S, Girman S, Lu B, Bischoff N, Holmes T, Shearer R, Wright LS, Svendsen CN, Gamm DM, Lund RD. Long-term vision rescue by human neural progenitors in a rat model of photoreceptor degeneration. Investigative Ophthalmology & Visual Science. 49: 3201-6. PMID 18579765 DOI: 10.1167/iovs.08-1831  0.375
2008 Emborg ME, Ebert AD, Moirano J, Peng S, Suzuki M, Capowski E, Joers V, Roitberg BZ, Aebischer P, Svendsen CN. GDNF-secreting human neural progenitor cells increase tyrosine hydroxylase and VMAT2 expression in MPTP-treated cynomolgus monkeys. Cell Transplantation. 17: 383-95. PMID 18522241 DOI: 10.3727/096368908784423300  0.39
2008 Suzuki M, Svendsen CN. Combining growth factor and stem cell therapy for amyotrophic lateral sclerosis. Trends in Neurosciences. 31: 192-8. PMID 18329734 DOI: 10.1016/J.Tins.2008.01.006  0.435
2008 Gamm DM, Melvan JN, Shearer RL, Pinilla I, Sabat G, Svendsen CN, Wright LS. A novel serum-free method for culturing human prenatal retinal pigment epithelial cells. Investigative Ophthalmology & Visual Science. 49: 788-99. PMID 18235029 DOI: 10.1167/iovs.07-0777  0.353
2008 Bhattacharyya A, McMillan E, Wallace K, Tubon TC, Capowski EE, Svendsen CN. Normal Neurogenesis but Abnormal Gene Expression in Human Fragile X Cortical Progenitor Cells. Stem Cells and Development. 17: 107-17. PMID 18225979 DOI: 10.1089/scd.2007.0073  0.457
2008 Ebert AD, Beres AJ, Barber AE, Svendsen CN. Human neural progenitor cells over-expressing IGF-1 protect dopamine neurons and restore function in a rat model of Parkinson's disease. Experimental Neurology. 209: 213-23. PMID 18061591 DOI: 10.1016/J.Expneurol.2007.09.022  0.394
2008 Nelson AD, Suzuki M, Svendsen CN. A high concentration of epidermal growth factor increases the growth and survival of neurogenic radial glial cells within human neurosphere cultures. Stem Cells (Dayton, Ohio). 26: 348-55. PMID 18032704 DOI: 10.1634/Stemcells.2007-0299  0.388
2007 Suzuki M, McHugh J, Tork C, Shelley B, Klein SM, Aebischer P, Svendsen CN. GDNF secreting human neural progenitor cells protect dying motor neurons, but not their projection to muscle, in a rat model of familial ALS. Plos One. 2: e689. PMID 17668067 DOI: 10.1371/Journal.Pone.0000689  0.462
2007 Capowski EE, Schneider BL, Ebert AD, Seehus CR, Szulc J, Zufferey R, Aebischer P, Svendsen CN. Lentiviral vector-mediated genetic modification of human neural progenitor cells for ex vivo gene therapy. Journal of Neuroscience Methods. 163: 338-49. PMID 17397931 DOI: 10.1016/J.Jneumeth.2007.02.022  0.452
2007 Gamm DM, Wang S, Lu B, Girman S, Holmes T, Bischoff N, Shearer RL, Sauvé Y, Capowski E, Svendsen CN, Lund RD. Protection of visual functions by human neural progenitors in a rat model of retinal disease. Plos One. 2: e338. PMID 17396165 DOI: 10.1371/journal.pone.0000338  0.462
2007 Suzuki M, Tork C, Shelley B, McHugh J, Wallace K, Klein SM, Lindstrom MJ, Svendsen CN. Sexual dimorphism in disease onset and progression of a rat model of ALS. Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group On Motor Neuron Diseases. 8: 20-5. PMID 17364431 DOI: 10.1080/17482960600982447  0.349
2007 Weidenfeller C, Svendsen CN, Shusta EV. Differentiating embryonic neural progenitor cells induce blood-brain barrier properties. Journal of Neurochemistry. 101: 555-65. PMID 17254017 DOI: 10.1111/J.1471-4159.2006.04394.X  0.411
2007 Kim HJ, Sugimori M, Nakafuku M, Svendsen CN. Control of neurogenesis and tyrosine hydroxylase expression in neural progenitor cells through bHLH proteins and Nurr1. Experimental Neurology. 203: 394-405. PMID 17034791 DOI: 10.1016/j.expneurol.2006.08.029  0.413
2006 Suzuki M, Nelson AD, Eickstaedt JB, Wallace K, Wright LS, Svendsen CN. Glutamate enhances proliferation and neurogenesis in human neural progenitor cell cultures derived from the fetal cortex. The European Journal of Neuroscience. 24: 645-53. PMID 16848797 DOI: 10.1111/J.1460-9568.2006.04957.X  0.349
2006 Chan C, Moore BE, Cotman CW, Okano H, Tavares R, Hovanesian V, Pinar H, Johanson CE, Svendsen CN, Stopa EG. Musashi1 antigen expression in human fetal germinal matrix development. Experimental Neurology. 201: 515-8. PMID 16777095 DOI: 10.1016/J.Expneurol.2006.04.023  0.437
2006 Cai J, Shin S, Wright L, Liu Y, Zhou D, Xue H, Khrebtukova I, Mattson MP, Svendsen CN, Rao MS. Massively parallel signature sequencing profiling of fetal human neural precursor cells. Stem Cells and Development. 15: 232-44. PMID 16646669 DOI: 10.1089/Scd.2006.15.232  0.425
2006 Wright LS, Prowse KR, Wallace K, Linskens MH, Svendsen CN. Human progenitor cells isolated from the developing cortex undergo decreased neurogenesis and eventual senescence following expansion in vitro. Experimental Cell Research. 312: 2107-20. PMID 16631163 DOI: 10.1016/j.yexcr.2006.03.012  0.473
2006 Sherer TB, Fiske BK, Svendsen CN, Lang AE, Langston JW. Crossroads in GDNF therapy for Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 21: 136-41. PMID 16470786 DOI: 10.1002/mds.20861  0.304
2006 Behrstock S, Ebert A, McHugh J, Vosberg S, Moore J, Schneider B, Capowski E, Hei D, Kordower J, Aebischer P, Svendsen CN. Human neural progenitors deliver glial cell line-derived neurotrophic factor to parkinsonian rodents and aged primates. Gene Therapy. 13: 379-88. PMID 16355116 DOI: 10.1038/Sj.Gt.3302679  0.431
2006 Emborg M, Peng S, Moirano J, Ebert A, Suzuki M, Capowski B, Joers V, Roitberg B, Aebischer P, Svendsen C. Survival of human neural stem cells (HNSCs) expressing GDNF in mptp-treated rhesus monkeys Experimental Neurology. 198: 567. DOI: 10.1016/J.Expneurol.2006.02.039  0.43
2005 Kelly CM, Tyers P, Borg MT, Svendsen CN, Dunnett SB, Rosser AE. EGF and FGF-2 responsiveness of rat and mouse neural precursors derived from the embryonic CNS. Brain Research Bulletin. 68: 83-94. PMID 16325008 DOI: 10.1016/J.Brainresbull.2005.08.020  0.577
2005 Caldwell MA, He X, Svendsen CN. 5-Bromo-2'-deoxyuridine is selectively toxic to neuronal precursors in vitro. The European Journal of Neuroscience. 22: 2965-70. PMID 16324131 DOI: 10.1111/j.1460-9568.2005.04504.x  0.534
2005 Gamm DM, Nelson AD, Svendsen CN. Human retinal progenitor cells grown as neurospheres demonstrate time-dependent changes in neuronal and glial cell fate potential. Annals of the New York Academy of Sciences. 1049: 107-17. PMID 15965111 DOI: 10.1196/annals.1334.011  0.404
2005 Klein SM, Behrstock S, McHugh J, Hoffmann K, Wallace K, Suzuki M, Aebischer P, Svendsen CN. GDNF delivery using human neural progenitor cells in a rat model of ALS. Human Gene Therapy. 16: 509-21. PMID 15871682 DOI: 10.1089/Hum.2005.16.509  0.472
2005 Klein S, Svendsen CN. Stem cells in the injured spinal cord: reducing the pain and increasing the gain. Nature Neuroscience. 8: 259-60. PMID 15746908 DOI: 10.1038/nn0305-259  0.386
2005 Patel NK, Bunnage M, Plaha P, Svendsen CN, Heywood P, Gill SS. Intraputamenal infusion of glial cell line-derived neurotrophic factor in PD: a two-year outcome study. Annals of Neurology. 57: 298-302. PMID 15668979 DOI: 10.1002/ana.20374  0.355
2005 Li J, Spletter ML, Johnson DA, Wright LS, Svendsen CN, Johnson JA. Rotenone-induced caspase 9/3-independent and -dependent cell death in undifferentiated and differentiated human neural stem cells. Journal of Neurochemistry. 92: 462-76. PMID 15659217 DOI: 10.1111/J.1471-4159.2004.02872.X  0.334
2005 Li J, Johnson D, Calkins M, Wright L, Svendsen C, Johnson J. Stabilization of Nrf2 by tBHQ confers protection against oxidative stress-induced cell death in human neural stem cells. Toxicological Sciences : An Official Journal of the Society of Toxicology. 83: 313-28. PMID 15525690 DOI: 10.1093/Toxsci/Kfi027  0.394
2004 Caldwell MA, Garcion E, terBorg MG, He X, Svendsen CN. Heparin stabilizes FGF-2 and modulates striatal precursor cell behavior in response to EGF. Experimental Neurology. 188: 408-20. PMID 15246840 DOI: 10.1016/j.expneurol.2004.05.007  0.549
2004 McBride JL, Behrstock SP, Chen EY, Jakel RJ, Siegel I, Svendsen CN, Kordower JH. Human neural stem cell transplants improve motor function in a rat model of Huntington's disease. The Journal of Comparative Neurology. 475: 211-9. PMID 15211462 DOI: 10.1002/Cne.20176  0.431
2004 Le Belle JE, Caldwell MA, Svendsen CN. Improving the survival of human CNS precursor-derived neurons after transplantation. Journal of Neuroscience Research. 76: 174-83. PMID 15048915 DOI: 10.1002/jnr.20035  0.814
2004 Burnstein RM, Foltynie T, He X, Menon DK, Svendsen CN, Caldwell MA. Differentiation and migration of long term expanded human neural progenitors in a partial lesion model of Parkinson's disease. The International Journal of Biochemistry & Cell Biology. 36: 702-13. PMID 15010333 DOI: 10.1016/J.Biocel.2003.11.011  0.601
2004 Suzuki M, Wright LS, Marwah P, Lardy HA, Svendsen CN. Mitotic and neurogenic effects of dehydroepiandrosterone (DHEA) on human neural stem cell cultures derived from the fetal cortex. Proceedings of the National Academy of Sciences of the United States of America. 101: 3202-7. PMID 14973190 DOI: 10.1073/Pnas.0307325101  0.478
2003 Chandran S, Kato H, Gerreli D, Compston A, Svendsen CN, Allen ND. FGF-dependent generation of oligodendrocytes by a hedgehog-independent pathway. Development (Cambridge, England). 130: 6599-609. PMID 14660548 DOI: 10.1242/Dev.00871  0.346
2003 Wachs FP, Couillard-Despres S, Engelhardt M, Wilhelm D, Ploetz S, Vroemen M, Kaesbauer J, Uyanik G, Klucken J, Karl C, Tebbing J, Svendsen C, Weidner N, Kuhn HG, Winkler J, et al. High efficacy of clonal growth and expansion of adult neural stem cells. Laboratory Investigation; a Journal of Technical Methods and Pathology. 83: 949-62. PMID 12861035 DOI: 10.1097/01.Lab.0000075556.74231.A5  0.404
2003 Wright LS, Li J, Caldwell MA, Wallace K, Johnson JA, Svendsen CN. Gene expression in human neural stem cells: effects of leukemia inhibitory factor. Journal of Neurochemistry. 86: 179-95. PMID 12807438 DOI: 10.1046/j.1471-4159.2003.01826.x  0.584
2003 Gill SS, Patel NK, Hotton GR, O'Sullivan K, McCarter R, Bunnage M, Brooks DJ, Svendsen CN, Heywood P. Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease. Nature Medicine. 9: 589-95. PMID 12669033 DOI: 10.1038/Nm850  0.354
2002 Le Belle JE, Svendsen CN. Stem cells for neurodegenerative disorders: where can we go from here? Biodrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy. 16: 389-401. PMID 12463763 DOI: 10.2165/00063030-200216060-00001  0.838
2002 Ostenfeld T, Tai YT, Martin P, Déglon N, Aebischer P, Svendsen CN. Neurospheres modified to produce glial cell line-derived neurotrophic factor increase the survival of transplanted dopamine neurons. Journal of Neuroscience Research. 69: 955-65. PMID 12205689 DOI: 10.1002/jnr.10396  0.422
2002 Ostenfeld T, Joly E, Tai YT, Peters A, Caldwell M, Jauniaux E, Svendsen CN. Regional specification of rodent and human neurospheres. Brain Research. Developmental Brain Research. 134: 43-55. PMID 11947936 DOI: 10.1016/S0165-3806(01)00291-7  0.611
2002 Bahn S, Mimmack M, Ryan M, Caldwell MA, Jauniaux E, Starkey M, Svendsen CN, Emson P. Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: a gene expression study. Lancet. 359: 310-5. PMID 11830198 DOI: 10.1016/S0140-6736(02)07497-4  0.584
2001 Caldwell MA, He X, Wilkie N, Pollack S, Marshall G, Wafford KA, Svendsen CN. Growth factors regulate the survival and fate of cells derived from human neurospheres. Nature Biotechnology. 19: 475-9. PMID 11329020 DOI: 10.1038/88158  0.481
2001 McLaren FH, Svendsen CN, Van der Meide P, Joly E. Analysis of neural stem cells by flow cytometry: cellular differentiation modifies patterns of MHC expression. Journal of Neuroimmunology. 112: 35-46. PMID 11108931 DOI: 10.1016/S0165-5728(00)00410-0  0.448
2000 Armstrong RJE, Watts C, Svendsen CN, Dunnett SB, Rosser AE. Survival, Neuronal Differentiation, and Fiber Outgrowth of Propagated Human Neural Precursor Grafts in an Animal Model of Huntington's Disease. Cell Transplantation. 9: 55-64. PMID 28876110 DOI: 10.1177/096368970000900108  0.678
2000 Svendsen CN, Caldwell MA. Neural stem cells in the developing central nervous system: implications for cell therapy through transplantation. Progress in Brain Research. 127: 13-34. PMID 11142026 DOI: 10.1016/S0079-6123(00)27003-9  0.481
2000 Ostenfeld T, Caldwell MA, Prowse KR, Linskens MH, Jauniaux E, Svendsen CN. Human neural precursor cells express low levels of telomerase in vitro and show diminishing cell proliferation with extensive axonal outgrowth following transplantation. Experimental Neurology. 164: 215-26. PMID 10877932 DOI: 10.1006/exnr.2000.7427  0.481
2000 Armstrong RJ, Svendsen CN. Neural stem cells: from cell biology to cell replacement. Cell Transplantation. 9: 139-52. PMID 10811389 DOI: 10.1177/096368970000900202  0.443
2000 Armstrong RJ, Watts C, Svendsen CN, Dunnett SB, Rosser AE. Survival, neuronal differentiation, and fiber outgrowth of propagated human neural precursor grafts in an animal model of Huntington's disease. Cell Transplantation. 9: 55-64. PMID 10784067 DOI: 10.1177/096368970000900108  0.706
1999 Phillips T, Rees S, Augood S, Waldvogel H, Faull R, Svendsen C, Emson P. Localization of metabotropic glutamate receptor type 2 in the human brain Neuroscience. 95: 1139-1156. PMID 10682721 DOI: 10.1016/S0306-4522(99)00353-X  0.341
1999 Ostenfeld T, Horn P, Aardal C, Orpen I, Caldwell MA, Svendsen CN. Mouse epidermal growth factor-responsive neural precursor cells increase the survival and functional capacity of embryonic rat dopamine neurons in vitro. Neuroreport. 10: 1985-92. PMID 10501545 DOI: 10.1097/00001756-199906230-00035  0.481
1999 Svendsen CN, Caldwell MA, Ostenfeld T. Human neural stem cells: isolation, expansion and transplantation. Brain Pathology (Zurich, Switzerland). 9: 499-513. PMID 10416990 DOI: 10.1111/J.1750-3639.1999.Tb00538.X  0.481
1999 Bahn S, Wisden W, Dunnett SB, Svendsen C. The intrinsic specification of gamma-aminobutyric acid type A receptor alpha6 subunit gene expression in cerebellar granule cells. The European Journal of Neuroscience. 11: 2194-8. PMID 10336690 DOI: 10.1046/J.1460-9568.1999.00662.X  0.483
1998 Svendsen CN, ter Borg MG, Armstrong RJ, Rosser AE, Chandran S, Ostenfeld T, Caldwell MA. A new method for the rapid and long term growth of human neural precursor cells. Journal of Neuroscience Methods. 85: 141-52. PMID 9874150 DOI: 10.1016/S0165-0270(98)00126-5  0.603
1998 Caldwell MA, Svendsen CN. Heparin, but not other proteoglycans potentiates the mitogenic effects of FGF-2 on mesencephalic precursor cells. Experimental Neurology. 152: 1-10. PMID 9682007 DOI: 10.1006/exnr.1998.6815  0.481
1997 Svendsen CN, Caldwell MA, Shen J, ter Borg MG, Rosser AE, Tyers P, Karmiol S, Dunnett SB. Long-term survival of human central nervous system progenitor cells transplanted into a rat model of Parkinson's disease. Experimental Neurology. 148: 135-46. PMID 9398456 DOI: 10.1006/Exnr.1997.6634  0.691
1997 Rosser AE, Tyers P, ter Borg M, Dunnett SB, Svendsen CN. Co-expression of MAP-2 and GFAP in cells developing from rat EGF responsive precursor cells. Brain Research. Developmental Brain Research. 98: 291-5. PMID 9051273 DOI: 10.1016/S0165-3806(96)00189-7  0.525
1996 Sinclair SR, Svendsen CN, Torres EM, Martin D, Fawcett JW, Dunnett SB. GDNF enhances dopaminergic cell survival and fibre outgrowth in embryonic nigral grafts. Neuroreport. 7: 2547-52. PMID 8981421 DOI: 10.1097/00001756-199611040-00029  0.504
1996 De Lacalle S, Cooper JD, Svendsen CN, Dunnett SB, Sofroniew MV. Reduced retrograde labelling with fluorescent tracer accompanies neuronal atrophy of basal forebrain cholinergic neurons in aged rats. Neuroscience. 75: 19-27. PMID 8923519 DOI: 10.1016/0306-4522(96)00239-4  0.506
1996 Döbrössy MD, Svendsen CN, Dunnett SB. Bilateral striatal lesions impair retention of an operant test of short-term memory. Brain Research Bulletin. 41: 159-65. PMID 8886385 DOI: 10.1016/S0361-9230(96)00160-8  0.426
1996 Svendsen CN, Clarke DJ, Rosser AE, Dunnett SB. Survival and differentiation of rat and human epidermal growth factor-responsive precursor cells following grafting into the lesioned adult central nervous system. Experimental Neurology. 137: 376-88. PMID 8635554 DOI: 10.1006/Exnr.1996.0039  0.6
1995 Döbrössy MD, Svendsen CN, Dunnett SB. The effects of bilateral striatal lesions on the acquisition of an operant test of short term memory. Neuroreport. 6: 2049-53. PMID 8580438 DOI: 10.1097/00001756-199510010-00023  0.427
1995 Svendsen CN, Fawcett JW, Bentlage C, Dunnett SB. Increased survival of rat EGF-generated CNS precursor cells using B27 supplemented medium. Experimental Brain Research. 102: 407-14. PMID 7737387 DOI: 10.1007/Bf00230645  0.545
1995 Svendsen CN, Dunnett SB. When can neural tissue be transplanted? Eye (London, England). 9: 233-5. PMID 7556723 DOI: 10.1038/eye.1995.45  0.466
1994 Svendsen CN, Kew JN, Staley K, Sofroniew MV. Death of developing septal cholinergic neurons following NGF withdrawal in vitro: protection by protein synthesis inhibition. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 75-87. PMID 8283253 DOI: 10.1523/Jneurosci.14-01-00075.1994  0.337
1993 Dunnett SB, Svendsen CN. Huntington's disease: animal models and transplantation repair. Current Opinion in Neurobiology. 3: 790-6. PMID 8260831 DOI: 10.1016/0959-4388(93)90155-R  0.559
1993 Sofroniew MV, Cooper JD, Svendsen CN, Crossman P, Ip NY, Lindsay RM, Zafra F, Lindholm D. Atrophy but not death of adult septal cholinergic neurons after ablation of target capacity to produce mRNAs for NGF, BDNF, and NT3. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 5263-76. PMID 8254373 DOI: 10.1523/Jneurosci.13-12-05263.1993  0.339
1991 Svendsen CN, Cooper JD, Sofroniew MV. Trophic factor effects on septal cholinergic neurons. Annals of the New York Academy of Sciences. 640: 91-4. PMID 1776766 DOI: 10.1111/J.1749-6632.1991.Tb00197.X  0.36
1990 O'Brien TS, Svendsen CN, Isacson O, Sofroniew MV. Loss of true blue labelling from the medial septum following transection of the fimbria-fornix: evidence for the death of cholinergic and non-cholinergic neurons. Brain Research. 508: 249-56. PMID 2306616 DOI: 10.1016/0006-8993(90)90403-X  0.37
1990 Sofroniew MV, Galletly NP, Isacson O, Svendsen CN. Survival of adult basal forebrain cholinergic neurons after loss of target neurons. Science (New York, N.Y.). 247: 338-42. PMID 1688664 DOI: 10.1126/Science.1688664  0.373
Show low-probability matches.