| Year |
Citation |
Score |
| 2020 |
Workman MJ, Troisi E, Targan SR, Svendsen CN, Barrett RJ. Modeling Intestinal Epithelial Response to Interferon-γ in Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids. International Journal of Molecular Sciences. 22. PMID 33396621 DOI: 10.3390/ijms22010288 |
0.84 |
|
| 2020 |
Ho R, Workman MJ, Mathkar P, Wu K, Kim KJ, O'Rourke JG, Kellogg M, Montel V, Banuelos MG, Arogundade OA, Diaz-Garcia S, Oheb D, Huang S, Khrebtukova I, Watson L, ... ... Svendsen CN, et al. Cross-Comparison of Human iPSC Motor Neuron Models of Familial and Sporadic ALS Reveals Early and Convergent Transcriptomic Disease Signatures. Cell Systems. PMID 33382996 DOI: 10.1016/j.cels.2020.10.010 |
0.76 |
|
| 2020 |
Das Sharma S, Pal R, Reddy BK, Selvaraj BT, Raj N, Samaga KK, Srinivasan DJ, Ornelas L, Sareen D, Livesey MR, Bassell GJ, Svendsen CN, Kind PC, Chandran S, Chattarji S, et al. Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns. Molecular Autism. 11: 52. PMID 32560741 DOI: 10.1186/s13229-020-00351-4 |
0.68 |
|
| 2020 |
Toombs J, Panther L, Ornelas L, Liu C, Gomez E, Martín-Ibáñez R, Cox SR, Ritchie SJ, Harris SE, Taylor A, Redmond P, Russ TC, Murphy L, Cooper JD, Burr K, ... ... Svendsen CN, et al. Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian Birth Cohort 1936. Stem Cell Research. 46: 101851. PMID 32450543 DOI: 10.1016/j.scr.2020.101851 |
0.68 |
|
| 2020 |
Workman MJ, Svendsen CN. Recent advances in human iPSC-derived models of the blood-brain barrier. Fluids and Barriers of the Cns. 17: 30. PMID 32321511 DOI: 10.1186/s12987-020-00191-7 |
0.76 |
|
| 2020 |
Jagadeesan S, Workman MJ, Herland A, Svendsen CN, Vatine GD. Generation of a Human iPSC-Based Blood-Brain Barrier Chip. Journal of Visualized Experiments : Jove. PMID 32176199 DOI: 10.3791/60925 |
0.76 |
|
| 2020 |
Sharma A, Sances S, Workman MJ, Svendsen CN. Multi-lineage Human iPSC-Derived Platforms for Disease Modeling and Drug Discovery. Cell Stem Cell. 26: 309-329. PMID 32142662 DOI: 10.1016/j.stem.2020.02.011 |
0.76 |
|
| 2020 |
Gleeson JP, Estrada HQ, Yamashita M, Svendsen CN, Targan SR, Barrett RJ. Development of Physiologically Responsive Human iPSC-Derived Intestinal Epithelium to Study Barrier Dysfunction in IBD. International Journal of Molecular Sciences. 21. PMID 32093254 DOI: 10.3390/ijms21041438 |
0.84 |
|
| 2020 |
Laperle AH, Sances S, Yucer N, Dardov VJ, Garcia VJ, Ho R, Fulton AN, Jones MR, Roxas KM, Avalos P, West D, Banuelos MG, Shu Z, Murali R, Maidment NT, ... ... Svendsen CN, et al. iPSC modeling of young-onset Parkinson's disease reveals a molecular signature of disease and novel therapeutic candidates. Nature Medicine. PMID 31988461 DOI: 10.1038/s41591-019-0739-1 |
0.48 |
|
| 2019 |
Garcia VJ, Rushton DJ, Tom CM, Allen ND, Kemp PJ, Svendsen CN, Mattis VB. Huntington's Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support. Frontiers in Neuroscience. 13: 669. PMID 31316341 DOI: 10.3389/fnins.2019.00669 |
0.88 |
|
| 2019 |
Vatine GD, Barrile R, Workman MJ, Sances S, Barriga BK, Rahnama M, Barthakur S, Kasendra M, Lucchesi C, Kerns J, Wen N, Spivia WR, Chen Z, Van Eyk J, Svendsen CN. Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications. Cell Stem Cell. 24: 995-1005.e6. PMID 31173718 DOI: 10.1016/j.stem.2019.05.011 |
0.76 |
|
| 2019 |
Das MM, Godoy M, Chen S, Moser VA, Avalos P, Roxas KM, Dang I, Yáñez A, Zhang W, Bresee C, Arditi M, Liu GY, Svendsen CN, Goodridge HS. Young bone marrow transplantation preserves learning and memory in old mice. Communications Biology. 2: 73. PMID 30820468 DOI: 10.1038/s42003-019-0298-5 |
0.44 |
|
| 2018 |
Workman MJ, Gleeson JP, Troisi EJ, Estrada HQ, Kerns SJ, Hinojosa CD, Hamilton GA, Targan SR, Svendsen CN, Barrett RJ. Enhanced Utilization of Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids Using Microengineered Chips. Cellular and Molecular Gastroenterology and Hepatology. 5: 669-677.e2. PMID 29930984 DOI: 10.1016/j.jcmgh.2017.12.008 |
0.84 |
|
| 2018 |
Akhtar AA, Gowing G, Kobritz N, Savinoff SE, Garcia L, Saxon D, Cho N, Kim G, Tom CM, Park H, Lawless G, Shelley BC, Mattis VB, Breunig JJ, Svendsen CN. Inducible Expression of GDNF in Transplanted iPSC-Derived Neural Progenitor Cells. Stem Cell Reports. PMID 29706501 DOI: 10.1016/j.stemcr.2018.03.024 |
0.88 |
|
| 2018 |
Thomsen GM, Avalos P, Ma AA, Alkaslasi M, Cho N, Wyss L, Vit JP, Godoy M, Suezaki P, Shelest O, Bankiewicz KS, Svendsen CN. Transplantation of Neural Progenitor Cells Expressing Glial Cell Line-Derived Neurotrophic Factor into the Motor Cortex as a Strategy to Treat Amyotrophic Lateral Sclerosis. Stem Cells (Dayton, Ohio). PMID 29656478 DOI: 10.1002/stem.2825 |
0.32 |
|
| 2018 |
Sances S, Ho R, Vatine G, West D, Laperle A, Meyer A, Godoy M, Kay PS, Mandefro B, Hatata S, Hinojosa C, Wen N, Sareen D, Hamilton GA, Svendsen CN. Human iPSC-Derived Endothelial Cells and Microengineered Organ-Chip Enhance Neuronal Development. Stem Cell Reports. PMID 29576540 DOI: 10.1016/j.stemcr.2018.02.012 |
0.76 |
|
| 2018 |
Mattis VB, Svendsen CN. Huntington modeling improves with age. Nature Neuroscience. PMID 29476127 DOI: 10.1038/s41593-018-0086-4 |
0.88 |
|
| 2018 |
Keenan AB, Jenkins SL, Jagodnik KM, Koplev S, He E, Torre D, Wang Z, Dohlman AB, Silverstein MC, Lachmann A, Kuleshov MV, Ma'ayan A, Stathias V, Terryn R, Cooper D, ... ... Svendsen CN, et al. The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations. Cell Systems. 6: 13-24. PMID 29199020 DOI: 10.1016/j.cels.2017.11.001 |
0.44 |
|
| 2017 |
Rushton DJ, Andres PL, Allred P, Baloh RH, Svendsen CN. Patients with ALS show highly correlated progression rates in left and right limb muscles. Neurology. PMID 28600459 DOI: 10.1212/WNL.0000000000004105 |
0.48 |
|
| 2017 |
Vatine GD, Al-Ahmad A, Barriga BK, Svendsen S, Salim A, Garcia L, Garcia VJ, Ho R, Yucer N, Qian T, Lim RG, Wu J, Thompson LM, Spivia WR, Chen Z, ... ... Svendsen CN, et al. Modeling Psychomotor Retardation using iPSCs from MCT8-Deficient Patients Indicates a Prominent Role for the Blood-Brain Barrier. Cell Stem Cell. PMID 28526555 DOI: 10.1016/j.stem.2017.04.002 |
0.48 |
|
| 2016 |
Thomsen GM, Ma A, Ko A, Harada MY, Wyss L, Haro P, Vit JP, Shelest O, Rhee P, Svendsen CN, Ley EJ. A model of recurrent concussion that leads to long-term motor deficits, CTE-like tauopathy and exacerbation of an ALS phenotype. The Journal of Trauma and Acute Care Surgery. PMID 27602892 DOI: 10.1097/TA.0000000000001248 |
0.32 |
|
| 2016 |
Ho R, Sances S, Gowing G, Amoroso MW, O'Rourke JG, Sahabian A, Wichterle H, Baloh RH, Sareen D, Svendsen CN. ALS disrupts spinal motor neuron maturation and aging pathways within gene co-expression networks. Nature Neuroscience. PMID 27428653 DOI: 10.1038/nn.4345 |
0.44 |
|
| 2016 |
Milani P, Escalante-Chong R, Shelley BC, Patel-Murray NL, Xin X, Adam M, Mandefro B, Sareen D, Svendsen CN, Fraenkel E. Cell freezing protocol suitable for ATAC-Seq on motor neurons derived from human induced pluripotent stem cells. Scientific Reports. 6: 25474. PMID 27146274 DOI: 10.1038/srep25474 |
1 |
|
| 2016 |
Das MM, Avalos P, Suezaki P, Godoy M, Garcia L, Chang CD, Vit JP, Shelley B, Gowing G, Svendsen CN. Human neural progenitors differentiate into astrocytes and protect motor neurons in aging rats. Experimental Neurology. PMID 27032721 DOI: 10.1016/j.expneurol.2016.03.023 |
1 |
|
| 2016 |
Sances S, Bruijn LI, Chandran S, Eggan K, Ho R, Klim JR, Livesey MR, Lowry E, Macklis JD, Rushton D, Sadegh C, Sareen D, Wichterle H, Zhang SC, Svendsen CN. Modeling ALS with motor neurons derived from human induced pluripotent stem cells. Nature Neuroscience. 16: 542-53. PMID 27021939 DOI: 10.1038/nn.4273 |
0.68 |
|
| 2016 |
Hjelm BE, Grunseich C, Gowing G, Avalos P, Tian J, Shelley BC, Mooney M, Narwani K, Shi Y, Svendsen CN, Wolfe JH, Fischbeck KH, Pierson TM. Mifepristone-inducible transgene expression in neural progenitor cells in vitro and in vivo. Gene Therapy. PMID 26863047 DOI: 10.1038/gt.2016.13 |
0.48 |
|
| 2016 |
Suzuki M, Svendsen CN. Ex Vivo Gene Therapy Using Human Mesenchymal Stem Cells to Deliver Growth Factors in the Skeletal Muscle of a Familial ALS Rat Model. Methods in Molecular Biology (Clifton, N.J.). 1382: 325-36. PMID 26611598 DOI: 10.1007/978-1-4939-3271-9_24 |
1 |
|
| 2015 |
Bakondi B, Lv W, Lu B, Jones MK, Tsai Y, Kim KJ, Levy R, Akhtar AA, Breunig JJ, Svendsen CN, Wang S. In Vivo CRISPR/Cas9 Gene Editing Corrects Retinal Dystrophy in the S334ter-3 Rat Model of Autosomal Dominant Retinitis Pigmentosa. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 26666451 DOI: 10.1038/mt.2015.220 |
1 |
|
| 2015 |
Thomsen GM, Vit JP, Lamb A, Gowing G, Shelest O, Alkaslasi M, Ley EJ, Svendsen CN. Acute Traumatic Brain Injury Does Not Exacerbate Amyotrophic Lateral Sclerosis in the SOD1 (G93A) Rat Model(1,2,3). Eneuro. 2. PMID 26464984 DOI: 10.1523/ENEURO.0059-14.2015 |
0.32 |
|
| 2015 |
Mattis VB, Svendsen CN. Modeling Huntington׳s disease with patient-derived neurons. Brain Research. PMID 26459990 DOI: 10.1016/j.brainres.2015.10.001 |
0.88 |
|
| 2015 |
Straccia M, Garcia-Diaz Barriga G, Sanders P, Bombau G, Carrere J, Mairal PB, Vinh NN, Yung S, Kelly CM, Svendsen CN, Kemp PJ, Arjomand J, Schoenfeld RC, Alberch J, Allen ND, et al. Quantitative high-throughput gene expression profiling of human striatal development to screen stem cell-derived medium spiny neurons. Molecular Therapy. Methods & Clinical Development. 2: 15030. PMID 26417608 DOI: 10.1038/mtm.2015.30 |
0.96 |
|
| 2015 |
Levy M, Boulis N, Rao M, Svendsen CN. Regenerative cellular therapies for neurologic diseases. Brain Research. PMID 26239912 DOI: 10.1016/j.brainres.2015.06.053 |
1 |
|
| 2015 |
Hatada S, Subramanian A, Mandefro B, Ren S, Kim HW, Tang J, Funari V, Baloh RH, Sareen D, Arumugaswami V, Svendsen CN. Low-Dose Irradiation Enhances Gene Targeting in Human Pluripotent Stem Cells. Stem Cells Translational Medicine. PMID 26185257 DOI: 10.5966/sctm.2015-0050 |
1 |
|
| 2015 |
Bernau K, Lewis CM, Petelinsek AM, Reagan MS, Niles DJ, Mattis VB, Meyerand ME, Suzuki M, Svendsen CN. In Vivo Tracking of Human Neural Progenitor Cells in the Rat Brain Using Magnetic Resonance Imaging is Not Enhanced by Ferritin Expression. Cell Transplantation. PMID 26160767 DOI: 10.3727/096368915X688614 |
1 |
|
| 2015 |
Gutierrez J, Lamanna JJ, Grin N, Hurtig CV, Miller JH, Riley J, Urquia L, Avalos P, Svendsen CN, Federici T, Boulis NM. Preclinical Validation of Multilevel Intraparenchymal Stem Cell Therapy in the Porcine Spinal Cord. Neurosurgery. 77: 604-12. PMID 26134596 DOI: 10.1227/NEU.0000000000000882 |
1 |
|
| 2015 |
Tsai Y, Lu B, Bakondi B, Girman S, Sahabian A, Sareen D, Svendsen CN, Wang S. Human iPSC-Derived Neural Progenitors Preserve Vision in an AMD-Like Model. Stem Cells (Dayton, Ohio). PMID 25869002 DOI: 10.1002/stem.2032 |
1 |
|
| 2015 |
Mattis VB, Tom C, Akimov S, Saeedian J, Østergaard ME, Southwell AL, Doty CN, Ornelas L, Sahabian A, Lenaeus L, Mandefro B, Sareen D, Arjomand J, Hayden MR, Ross CA, ... Svendsen CN, et al. HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity. Human Molecular Genetics. 24: 3257-71. PMID 25740845 DOI: 10.1093/hmg/ddv080 |
1 |
|
| 2015 |
Kong SY, Park MH, Lee M, Kim JO, Lee HR, Han BW, Svendsen CN, Sung SH, Kim HJ. Kuwanon V inhibits proliferation, promotes cell survival and increases neurogenesis of neural stem cells. Plos One. 10: e0118188. PMID 25706719 DOI: 10.1371/journal.pone.0118188 |
1 |
|
| 2015 |
Das MM, Svendsen CN. Astrocytes show reduced support of motor neurons with aging that is accelerated in a rodent model of ALS. Neurobiology of Aging. 36: 1130-9. PMID 25443290 DOI: 10.1016/j.neurobiolaging.2014.09.020 |
1 |
|
| 2014 |
Lu XH, Mattis VB, Wang N, Al-Ramahi I, van den Berg N, Fratantoni SA, Waldvogel H, Greiner E, Osmand A, Elzein K, Xiao J, Dijkstra S, de Pril R, Vinters HV, Faull R, ... ... Svendsen CN, et al. Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease. Science Translational Medicine. 6: 268ra178. PMID 25540325 DOI: 10.1126/scitranslmed.3010523 |
1 |
|
| 2014 |
Thomsen GM, Gowing G, Latter J, Chen M, Vit JP, Staggenborg K, Avalos P, Alkaslasi M, Ferraiuolo L, Likhite S, Kaspar BK, Svendsen CN. Delayed disease onset and extended survival in the SOD1G93A rat model of amyotrophic lateral sclerosis after suppression of mutant SOD1 in the motor cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 15587-600. PMID 25411487 DOI: 10.1523/JNEUROSCI.2037-14.2014 |
1 |
|
| 2014 |
Barrett R, Ornelas L, Yeager N, Mandefro B, Sahabian A, Lenaeus L, Targan SR, Svendsen CN, Sareen D. Reliable generation of induced pluripotent stem cells from human lymphoblastoid cell lines. Stem Cells Translational Medicine. 3: 1429-34. PMID 25298370 DOI: 10.5966/sctm.2014-0121 |
1 |
|
| 2014 |
Rosser A, Svendsen CN. Stem cells for cell replacement therapy: a therapeutic strategy for HD? Movement Disorders : Official Journal of the Movement Disorder Society. 29: 1446-54. PMID 25216372 DOI: 10.1002/mds.26026 |
1 |
|
| 2014 |
Sareen D, Saghizadeh M, Ornelas L, Winkler MA, Narwani K, Sahabian A, Funari VA, Tang J, Spurka L, Punj V, Maguen E, Rabinowitz YS, Svendsen CN, Ljubimov AV. Differentiation of human limbal-derived induced pluripotent stem cells into limbal-like epithelium. Stem Cells Translational Medicine. 3: 1002-12. PMID 25069777 DOI: 10.5966/sctm.2014-0076 |
1 |
|
| 2014 |
Shelley BC, Gowing G, Svendsen CN. A cGMP-applicable expansion method for aggregates of human neural stem and progenitor cells derived from pluripotent stem cells or fetal brain tissue. Journal of Visualized Experiments : Jove. PMID 24962813 DOI: 10.3791/51219 |
1 |
|
| 2014 |
Bernau K, Lewis CM, Petelinsek AM, Benink HA, Zimprich CA, Meyerand ME, Suzuki M, Svendsen CN. In vivo tracking of human neural progenitor cells in the rat brain using bioluminescence imaging. Journal of Neuroscience Methods. 228: 67-78. PMID 24675049 DOI: 10.1016/j.jneumeth.2014.03.005 |
1 |
|
| 2014 |
Thomsen GM, Gowing G, Svendsen S, Svendsen CN. The past, present and future of stem cell clinical trials for ALS. Experimental Neurology. 262: 127-37. PMID 24613827 DOI: 10.1016/j.expneurol.2014.02.021 |
1 |
|
| 2014 |
Sareen D, Gowing G, Sahabian A, Staggenborg K, Paradis R, Avalos P, Latter J, Ornelas L, Garcia L, Svendsen CN. Human induced pluripotent stem cells are a novel source of neural progenitor cells (iNPCs) that migrate and integrate in the rodent spinal cord. The Journal of Comparative Neurology. 522: 2707-28. PMID 24610630 DOI: 10.1002/cne.23578 |
1 |
|
| 2014 |
Saitta B, Passarini J, Sareen D, Ornelas L, Sahabian A, Argade S, Krakow D, Cohn DH, Svendsen CN, Rimoin DL. Patient-derived skeletal dysplasia induced pluripotent stem cells display abnormal chondrogenic marker expression and regulation by BMP2 and TGFβ1. Stem Cells and Development. 23: 1464-78. PMID 24559391 DOI: 10.1089/scd.2014.0014 |
1 |
|
| 2014 |
Donangelo I, Ren SG, Eigler T, Svendsen C, Melmed S. Sca1+ murine pituitary adenoma cells show tumor-growth advantage Endocrine-Related Cancer. 21: 203-216. PMID 24481638 DOI: 10.1530/ERC-13-0229 |
1 |
|
| 2014 |
Mattis VB, Wakeman DR, Tom C, Dodiya HB, Yeung SY, Tran AH, Bernau K, Ornelas L, Sahabian A, Reidling J, Sareen D, Thompson LM, Kordower JH, Svendsen CN. Neonatal immune-tolerance in mice does not prevent xenograft rejection. Experimental Neurology. 254: 90-8. PMID 24440640 DOI: 10.1016/j.expneurol.2014.01.007 |
1 |
|
| 2014 |
Tsai Y, Lu B, Ljubimov AV, Girman S, Ross-Cisneros FN, Sadun AA, Svendsen CN, Cohen RM, Wang S. Ocular changes in TgF344-AD rat model of Alzheimer's disease. Investigative Ophthalmology & Visual Science. 55: 523-34. PMID 24398104 DOI: 10.1167/iovs.13-12888 |
1 |
|
| 2014 |
Gowing G, Shelley B, Staggenborg K, Hurley A, Avalos P, Victoroff J, Latter J, Garcia L, Svendsen CN. Glial cell line-derived neurotrophic factor-secreting human neural progenitors show long-term survival, maturation into astrocytes, and no tumor formation following transplantation into the spinal cord of immunocompromised rats. Neuroreport. 25: 367-72. PMID 24284956 DOI: 10.1097/WNR.0000000000000092 |
1 |
|
| 2013 |
Rushton DJ, Mattis VB, Svendsen CN, Allen ND, Kemp PJ. Stimulation of GABA-induced Ca2+ influx enhances maturation of human induced pluripotent stem cell-derived neurons. Plos One. 8: e81031. PMID 24278369 DOI: 10.1371/journal.pone.0081031 |
1 |
|
| 2013 |
Saghizadeh M, Winkler MA, Kramerov AA, Hemmati DM, Ghiam CA, Dimitrijevich SD, Sareen D, Ornelas L, Ghiasi H, Brunken WJ, Maguen E, Rabinowitz YS, Svendsen CN, Jirsova K, Ljubimov AV. A simple alkaline method for decellularizing human amniotic membrane for cell culture. Plos One. 8: e79632. PMID 24236148 DOI: 10.1371/journal.pone.0079632 |
1 |
|
| 2013 |
Sareen D, O'Rourke JG, Meera P, Muhammad AK, Grant S, Simpkinson M, Bell S, Carmona S, Ornelas L, Sahabian A, Gendron T, Petrucelli L, Baughn M, Ravits J, Harms MB, ... ... Svendsen CN, et al. Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion. Science Translational Medicine. 5: 208ra149. PMID 24154603 DOI: 10.1126/scitranslmed.3007529 |
1 |
|
| 2013 |
Svendsen CN. Back to the future: how human induced pluripotent stem cells will transform regenerative medicine. Human Molecular Genetics. 22: R32-8. PMID 23945396 DOI: 10.1093/hmg/ddt379 |
1 |
|
| 2013 |
Krakora D, Mulcrone P, Meyer M, Lewis C, Bernau K, Gowing G, Zimprich C, Aebischer P, Svendsen CN, Suzuki M. Synergistic effects of GDNF and VEGF on lifespan and disease progression in a familial ALS rat model. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 1602-10. PMID 23712039 DOI: 10.1038/mt.2013.108 |
1 |
|
| 2013 |
Ebert AD, Shelley BC, Hurley AM, Onorati M, Castiglioni V, Patitucci TN, Svendsen SP, Mattis VB, McGivern JV, Schwab AJ, Sareen D, Kim HW, Cattaneo E, Svendsen CN. EZ spheres: a stable and expandable culture system for the generation of pre-rosette multipotent stem cells from human ESCs and iPSCs. Stem Cell Research. 10: 417-27. PMID 23474892 DOI: 10.1016/j.scr.2013.01.009 |
1 |
|
| 2013 |
Nichols NL, Gowing G, Satriotomo I, Nashold LJ, Dale EA, Suzuki M, Avalos P, Mulcrone PL, McHugh J, Svendsen CN, Mitchell GS. Intermittent hypoxia and stem cell implants preserve breathing capacity in a rodent model of amyotrophic lateral sclerosis. American Journal of Respiratory and Critical Care Medicine. 187: 535-42. PMID 23220913 DOI: 10.1164/rccm.201206-1072OC |
1 |
|
| 2012 |
Keenan TM, Grinager JR, Procak AA, Svendsen CN. In vitro localization of human neural stem cell neurogenesis by engineered FGF-2 gradients. Integrative Biology : Quantitative Biosciences From Nano to Macro. 4: 1522-31. PMID 23147909 DOI: 10.1039/c2ib20074k |
1 |
|
| 2012 |
Wray S, Self M, Lewis PA, Taanman JW, Ryan NS, Mahoney CJ, Liang Y, Devine MJ, Sheerin UM, Houlden H, Morris HR, Healy D, et al. Creation of an open-access, mutation-defined fibroblast resource for neurological disease research. Plos One. 7: e43099. PMID 22952635 DOI: 10.1371/journal.pone.0043099 |
1 |
|
| 2012 |
Biancotti JC, Narwani K, Mandefro B, Golan-Lev T, Buehler N, Hill D, Svendsen CN, Benvenisty N. The in vitro survival of human monosomies and trisomies as embryonic stem cells. Stem Cell Research. 9: 218-24. PMID 22892439 DOI: 10.1016/j.scr.2012.07.002 |
1 |
|
| 2012 |
Breunig JJ, Gate D, Levy R, Rodriguez J, Kim GB, Danielpour M, Svendsen CN, Town T. Rapid genetic targeting of pial surface neural progenitors and immature neurons by neonatal electroporation. Neural Development. 7: 26. PMID 22776033 DOI: 10.1186/1749-8104-7-26 |
1 |
|
| 2012 |
Sareen D, Ebert AD, Heins BM, McGivern JV, Ornelas L, Svendsen CN. Inhibition of apoptosis blocks human motor neuron cell death in a stem cell model of spinal muscular atrophy. Plos One. 7: e39113. PMID 22723941 DOI: 10.1371/journal.pone.0039113 |
1 |
|
| 2012 |
Hayes-Punzo A, Mulcrone P, Meyer M, McHugh J, Svendsen CN, Suzuki M. Gonadectomy and dehydroepiandrosterone (DHEA) do not modulate disease progression in the G93A mutant SOD1 rat model of amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group On Motor Neuron Diseases. 13: 311-4. PMID 22409357 DOI: 10.3109/17482968.2012.654393 |
1 |
|
| 2012 |
Lindvall O, Barker RA, Brüstle O, Isacson O, Svendsen CN. Clinical translation of stem cells in neurodegenerative disorders. Cell Stem Cell. 10: 151-5. PMID 22305565 DOI: 10.1016/j.stem.2012.01.009 |
1 |
|
| 2012 |
Kitiyanant N, Kitiyanant Y, Svendsen CN, Thangnipon W. BDNF-, IGF-1- and GDNF-secreting human neural progenitor cells rescue amyloid β-induced toxicity in cultured rat septal neurons. Neurochemical Research. 37: 143-52. PMID 21909955 DOI: 10.1007/s11064-011-0592-1 |
1 |
|
| 2012 |
Mattis VB, Svendsen SP, Ebert A, Svendsen CN, King AR, Casale M, Winokur ST, Batugedara G, Vawter M, Donovan PJ, Lock LF, Thompson LM, Zhu Y, Fossale E, Atwal RS, et al. Induced pluripotent stem cells from patients with huntington’s disease show CAG repeat expansion associated phenotypes Cell Stem Cell. 11: 264-278. DOI: 10.1016/j.stem.2012.04.027 |
0.88 |
|
| 2011 |
Gowing G, Svendsen CN. Stem cell transplantation for motor neuron disease: current approaches and future perspectives. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 8: 591-606. PMID 21904789 DOI: 10.1007/s13311-011-0068-7 |
1 |
|
| 2011 |
Lippmann ES, Weidenfeller C, Svendsen CN, Shusta EV. Blood-brain barrier modeling with co-cultured neural progenitor cell-derived astrocytes and neurons. Journal of Neurochemistry. 119: 507-20. PMID 21854389 DOI: 10.1111/j.1471-4159.2011.07434.x |
1 |
|
| 2011 |
Kim HW, Svendsen CN. Gene editing in stem cells hits the target. Cell Stem Cell. 9: 93-4. PMID 21816359 DOI: 10.1016/j.stem.2011.07.011 |
1 |
|
| 2011 |
Andres RH, Horie N, Slikker W, Keren-Gill H, Zhan K, Sun G, Manley NC, Pereira MP, Sheikh LA, McMillan EL, Schaar BT, Svendsen CN, Bliss TM, Steinberg GK. Human neural stem cells enhance structural plasticity and axonal transport in the ischaemic brain. Brain : a Journal of Neurology. 134: 1777-89. PMID 21616972 DOI: 10.1093/brain/awr094 |
1 |
|
| 2011 |
Mattis VB, Svendsen CN. Induced pluripotent stem cells: a new revolution for clinical neurology? The Lancet. Neurology. 10: 383-94. PMID 21435601 DOI: 10.1016/S1474-4422(11)70022-9 |
1 |
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| 2011 |
Alexanian AR, Svendsen CN, Crowe MJ, Kurpad SN. Transplantation of human glial-restricted neural precursors into injured spinal cord promotes functional and sensory recovery without causing allodynia. Cytotherapy. 13: 61-8. PMID 20735167 DOI: 10.3109/14653249.2010.510504 |
1 |
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| 2010 |
Candolfi M, Xiong W, Yagiz K, Liu C, Muhammad AK, Puntel M, Foulad D, Zadmehr A, Ahlzadeh GE, Kroeger KM, Tesarfreund M, Lee S, Debinski W, Sareen D, Svendsen CN, et al. Gene therapy-mediated delivery of targeted cytotoxins for glioma therapeutics. Proceedings of the National Academy of Sciences of the United States of America. 107: 20021-6. PMID 21030678 DOI: 10.1073/pnas.1008261107 |
1 |
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| 2010 |
Keenan TM, Nelson AD, Grinager JR, Thelen JC, Svendsen CN. Real time imaging of human progenitor neurogenesis. Plos One. 5: e13187. PMID 20949053 DOI: 10.1371/journal.pone.0013187 |
1 |
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| 2010 |
Ebert AD, Svendsen CN. Stem cell model of spinal muscular atrophy. Archives of Neurology. 67: 665-9. PMID 20558385 DOI: 10.1001/archneurol.2010.89 |
1 |
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| 2010 |
Sareen D, Svendsen CN. Stem cell biologists sure play a mean pinball. Nature Biotechnology. 28: 333-5. PMID 20379177 DOI: 10.1038/nbt0410-333 |
1 |
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| 2010 |
Ebert AD, Svendsen CN. Human stem cells and drug screening: opportunities and challenges. Nature Reviews. Drug Discovery. 9: 367-72. PMID 20339370 DOI: 10.1038/nrd3000 |
1 |
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| 2010 |
Ebert AD, Barber AE, Heins BM, Svendsen CN. Ex vivo delivery of GDNF maintains motor function and prevents neuronal loss in a transgenic mouse model of Huntington's disease. Experimental Neurology. 224: 155-62. PMID 20227407 DOI: 10.1016/j.expneurol.2010.03.005 |
1 |
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| 2010 |
Suzuki M, Klein S, Wetzel EA, Meyer M, McHugh J, Tork C, Hayes A, Svendsen CN. Acute glial activation by stab injuries does not lead to overt damage or motor neuron degeneration in the G93A mutant SOD1 rat model of amyotrophic lateral sclerosis. Experimental Neurology. 221: 346-52. PMID 20005223 DOI: 10.1016/j.expneurol.2009.12.004 |
1 |
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| 2010 |
Svendsen C, Thies S. Stem cell-based therapeutics Nature Reviews Drug Discovery. 9: 83. DOI: 10.1038/nrd3089 |
1 |
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| 2009 |
Sareen D, McMillan E, Ebert AD, Shelley BC, Johnson JA, Meisner LF, Svendsen CN. Chromosome 7 and 19 trisomy in cultured human neural progenitor cells. Plos One. 4: e7630. PMID 19898616 DOI: 10.1371/journal.pone.0007630 |
1 |
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| 2009 |
Riley J, Federici T, Park J, Suzuki M, Franz CK, Tork C, McHugh J, Teng Q, Svendsen C, Boulis NM. Cervical spinal cord therapeutics delivery: preclinical safety validation of a stabilized microinjection platform. Neurosurgery. 65: 754-61; discussion 7. PMID 19834381 DOI: 10.1227/01.NEU.0000343524.45387.9E |
1 |
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| 2009 |
Bhattacharyya A, McMillan E, Chen SI, Wallace K, Svendsen CN. A critical period in cortical interneuron neurogenesis in down syndrome revealed by human neural progenitor cells. Developmental Neuroscience. 31: 497-510. PMID 19738365 DOI: 10.1159/000236899 |
1 |
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| 2009 |
Cairney CJ, Sanguinetti G, Ranghini E, Chantry AD, Nostro MC, Bhattacharyya A, Svendsen CN, Keith WN, Bellantuono I. A systems biology approach to Down syndrome: identification of Notch/Wnt dysregulation in a model of stem cells aging. Biochimica Et Biophysica Acta. 1792: 353-63. PMID 19419698 DOI: 10.1016/j.bbadis.2009.01.015 |
1 |
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| 2009 |
Ebert AD, Yu J, Rose FF, Mattis VB, Lorson CL, Thomson JA, Svendsen CN. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature. 457: 277-80. PMID 19098894 DOI: 10.1038/nature07677 |
1 |
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| 2009 |
Kim HJ, McMillan E, Han F, Svendsen CN. Regionally specified human neural progenitor cells derived from the mesencephalon and forebrain undergo increased neurogenesis following overexpression of ASCL1. Stem Cells (Dayton, Ohio). 27: 390-8. PMID 19008346 DOI: 10.1634/stemcells.2007-1047 |
1 |
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| 2008 |
Behrstock S, Ebert AD, Klein S, Schmitt M, Moore JM, Svendsen CN. Lesion-induced increase in survival and migration of human neural progenitor cells releasing GDNF. Cell Transplantation. 17: 753-62. PMID 19044202 DOI: 10.3727/096368908786516819 |
1 |
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| 2008 |
Ebert AD, McMillan EL, Svendsen CN. Isolating, expanding, and infecting human and rodent fetal neural progenitor cells. Current Protocols in Stem Cell Biology. Unit 2D.2. PMID 18819085 DOI: 10.1002/9780470151808.sc02d02s6 |
1 |
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| 2008 |
Gamm DM, Wright LS, Capowski EE, Shearer RL, Meyer JS, Kim HJ, Schneider BL, Melvan JN, Svendsen CN. Regulation of prenatal human retinal neurosphere growth and cell fate potential by retinal pigment epithelium and Mash1. Stem Cells (Dayton, Ohio). 26: 3182-93. PMID 18802035 DOI: 10.1634/stemcells.2008-0300 |
1 |
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| 2008 |
Suzuki M, McHugh J, Tork C, Shelley B, Hayes A, Bellantuono I, Aebischer P, Svendsen CN. Direct muscle delivery of GDNF with human mesenchymal stem cells improves motor neuron survival and function in a rat model of familial ALS. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 2002-10. PMID 18797452 DOI: 10.1038/mt.2008.197 |
1 |
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| 2008 |
Wang S, Girman S, Lu B, Bischoff N, Holmes T, Shearer R, Wright LS, Svendsen CN, Gamm DM, Lund RD. Long-term vision rescue by human neural progenitors in a rat model of photoreceptor degeneration. Investigative Ophthalmology & Visual Science. 49: 3201-6. PMID 18579765 DOI: 10.1167/iovs.08-1831 |
1 |
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| 2008 |
Emborg ME, Ebert AD, Moirano J, Peng S, Suzuki M, Capowski E, Joers V, Roitberg BZ, Aebischer P, Svendsen CN. GDNF-secreting human neural progenitor cells increase tyrosine hydroxylase and VMAT2 expression in MPTP-treated cynomolgus monkeys. Cell Transplantation. 17: 383-95. PMID 18522241 |
1 |
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| 2008 |
Svendsen C. Stem Cells and Parkinson's Disease: Toward a Treatment, Not a Cure Cell Stem Cell. 2: 412-413. PMID 18462691 DOI: 10.1016/j.stem.2008.04.010 |
1 |
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| 2008 |
Suzuki M, Svendsen CN. Combining growth factor and stem cell therapy for amyotrophic lateral sclerosis. Trends in Neurosciences. 31: 192-8. PMID 18329734 DOI: 10.1016/j.tins.2008.01.006 |
1 |
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| 2008 |
Gamm DM, Melvan JN, Shearer RL, Pinilla I, Sabat G, Svendsen CN, Wright LS. A novel serum-free method for culturing human prenatal retinal pigment epithelial cells. Investigative Ophthalmology & Visual Science. 49: 788-99. PMID 18235029 DOI: 10.1167/iovs.07-0777 |
1 |
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| 2008 |
Bhattacharyya A, McMillan E, Wallace K, Tubon TC, Capowski EE, Svendsen CN. Normal Neurogenesis but Abnormal Gene Expression in Human Fragile X Cortical Progenitor Cells. Stem Cells and Development. 17: 107-17. PMID 18225979 DOI: 10.1089/scd.2007.0073 |
1 |
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| 2008 |
Ebert AD, Beres AJ, Barber AE, Svendsen CN. Human neural progenitor cells over-expressing IGF-1 protect dopamine neurons and restore function in a rat model of Parkinson's disease. Experimental Neurology. 209: 213-23. PMID 18061591 DOI: 10.1016/j.expneurol.2007.09.022 |
1 |
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| 2008 |
Nelson AD, Suzuki M, Svendsen CN. A high concentration of epidermal growth factor increases the growth and survival of neurogenic radial glial cells within human neurosphere cultures. Stem Cells (Dayton, Ohio). 26: 348-55. PMID 18032704 DOI: 10.1634/stemcells.2007-0299 |
1 |
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| 2007 |
Svendsen C. The first steps towards gene therapy for Parkinson's disease Lancet Neurology. 6: 754-756. PMID 17706556 DOI: 10.1016/S1474-4422(07)70202-8 |
1 |
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| 2007 |
Suzuki M, McHugh J, Tork C, Shelley B, Klein SM, Aebischer P, Svendsen CN. GDNF secreting human neural progenitor cells protect dying motor neurons, but not their projection to muscle, in a rat model of familial ALS. Plos One. 2: e689. PMID 17668067 DOI: 10.1371/journal.pone.0000689 |
1 |
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| 2007 |
Capowski EE, Schneider BL, Ebert AD, Seehus CR, Szulc J, Zufferey R, Aebischer P, Svendsen CN. Lentiviral vector-mediated genetic modification of human neural progenitor cells for ex vivo gene therapy. Journal of Neuroscience Methods. 163: 338-49. PMID 17397931 DOI: 10.1016/j.jneumeth.2007.02.022 |
1 |
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| 2007 |
Gamm DM, Wang S, Lu B, Girman S, Holmes T, Bischoff N, Shearer RL, Sauvé Y, Capowski E, Svendsen CN, Lund RD. Protection of visual functions by human neural progenitors in a rat model of retinal disease. Plos One. 2: e338. PMID 17396165 DOI: 10.1371/journal.pone.0000338 |
1 |
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| 2007 |
Suzuki M, Tork C, Shelley B, McHugh J, Wallace K, Klein SM, Lindstrom MJ, Svendsen CN. Sexual dimorphism in disease onset and progression of a rat model of ALS. Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group On Motor Neuron Diseases. 8: 20-5. PMID 17364431 DOI: 10.1080/17482960600982447 |
1 |
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| 2007 |
Schneider BL, Seehus CR, Capowski EE, Aebischer P, Zhang SC, Svendsen CN. Over-expression of alpha-synuclein in human neural progenitors leads to specific changes in fate and differentiation. Human Molecular Genetics. 16: 651-66. PMID 17309880 DOI: 10.1093/hmg/ddm008 |
1 |
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| 2007 |
Weidenfeller C, Svendsen CN, Shusta EV. Differentiating embryonic neural progenitor cells induce blood-brain barrier properties. Journal of Neurochemistry. 101: 555-65. PMID 17254017 DOI: 10.1111/j.1471-4159.2006.04394.x |
1 |
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| 2007 |
Kim HJ, Sugimori M, Nakafuku M, Svendsen CN. Control of neurogenesis and tyrosine hydroxylase expression in neural progenitor cells through bHLH proteins and Nurr1. Experimental Neurology. 203: 394-405. PMID 17034791 DOI: 10.1016/j.expneurol.2006.08.029 |
1 |
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| 2006 |
Nelson AD, Svendsen CN. Low concentrations of extracellular FGF-2 are sufficient but not essential for neurogenesis from human neural progenitor cells. Molecular and Cellular Neurosciences. 33: 29-35. PMID 16860999 DOI: 10.1016/j.mcn.2006.06.003 |
1 |
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| 2006 |
Suzuki M, Nelson AD, Eickstaedt JB, Wallace K, Wright LS, Svendsen CN. Glutamate enhances proliferation and neurogenesis in human neural progenitor cell cultures derived from the fetal cortex. The European Journal of Neuroscience. 24: 645-53. PMID 16848797 DOI: 10.1111/j.1460-9568.2006.04957.x |
1 |
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| 2006 |
Chan C, Moore BE, Cotman CW, Okano H, Tavares R, Hovanesian V, Pinar H, Johanson CE, Svendsen CN, Stopa EG. Musashi1 antigen expression in human fetal germinal matrix development. Experimental Neurology. 201: 515-8. PMID 16777095 DOI: 10.1016/j.expneurol.2006.04.023 |
1 |
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| 2006 |
Cai J, Shin S, Wright L, Liu Y, Zhou D, Xue H, Khrebtukova I, Mattson MP, Svendsen CN, Rao MS. Massively parallel signature sequencing profiling of fetal human neural precursor cells. Stem Cells and Development. 15: 232-44. PMID 16646669 DOI: 10.1089/scd.2006.15.232 |
1 |
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| 2006 |
Wright LS, Prowse KR, Wallace K, Linskens MH, Svendsen CN. Human progenitor cells isolated from the developing cortex undergo decreased neurogenesis and eventual senescence following expansion in vitro. Experimental Cell Research. 312: 2107-20. PMID 16631163 DOI: 10.1016/j.yexcr.2006.03.012 |
1 |
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| 2006 |
Sherer TB, Fiske BK, Svendsen CN, Lang AE, Langston JW. Crossroads in GDNF therapy for Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 21: 136-41. PMID 16470786 DOI: 10.1002/mds.20861 |
1 |
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| 2006 |
Behrstock S, Ebert A, McHugh J, Vosberg S, Moore J, Schneider B, Capowski E, Hei D, Kordower J, Aebischer P, Svendsen CN. Human neural progenitors deliver glial cell line-derived neurotrophic factor to parkinsonian rodents and aged primates. Gene Therapy. 13: 379-88. PMID 16355116 DOI: 10.1038/sj.gt.3302679 |
1 |
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| 2006 |
Kirik D, Georgievska B, Behrstock S, Svendsen CN. Delivery of GDNF for Parkinson's disease: Transition of a neuroprotective treatment strategy from basic sciences to clinical application Restorative Therapies in Parkinson's Disease. 297-316. DOI: 10.1007/0-387-32823-2_15 |
1 |
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| 2006 |
Kim HJ, Paul G, Tai YT, Svendsen CN. Genetically modified cells as a source for grafting in Parkinson's disease Restorative Therapies in Parkinson's Disease. 285-296. DOI: 10.1007/0-387-32823-2_14 |
1 |
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| 2005 |
Kelly CM, Tyers P, Borg MT, Svendsen CN, Dunnett SB, Rosser AE. EGF and FGF-2 responsiveness of rat and mouse neural precursors derived from the embryonic CNS. Brain Research Bulletin. 68: 83-94. PMID 16325008 DOI: 10.1016/j.brainresbull.2005.08.020 |
1 |
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| 2005 |
Caldwell MA, He X, Svendsen CN. 5-Bromo-2'-deoxyuridine is selectively toxic to neuronal precursors in vitro. The European Journal of Neuroscience. 22: 2965-70. PMID 16324131 DOI: 10.1111/j.1460-9568.2005.04504.x |
1 |
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| 2005 |
Ebert AD, Svendsen CN. A new tool in the battle against Alzheimer's disease and aging: ex vivo gene therapy. Rejuvenation Research. 8: 131-4. PMID 16144466 DOI: 10.1089/rej.2005.8.131 |
1 |
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| 2005 |
Gamm DM, Nelson AD, Svendsen CN. Human retinal progenitor cells grown as neurospheres demonstrate time-dependent changes in neuronal and glial cell fate potential. Annals of the New York Academy of Sciences. 1049: 107-17. PMID 15965111 DOI: 10.1196/annals.1334.011 |
1 |
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| 2005 |
Klein SM, Behrstock S, McHugh J, Hoffmann K, Wallace K, Suzuki M, Aebischer P, Svendsen CN. GDNF delivery using human neural progenitor cells in a rat model of ALS. Human Gene Therapy. 16: 509-21. PMID 15871682 DOI: 10.1089/hum.2005.16.509 |
1 |
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| 2005 |
Klein S, Svendsen CN. Stem cells in the injured spinal cord: reducing the pain and increasing the gain. Nature Neuroscience. 8: 259-60. PMID 15746908 DOI: 10.1038/nn0305-259 |
1 |
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| 2005 |
Patel NK, Bunnage M, Plaha P, Svendsen CN, Heywood P, Gill SS. Intraputamenal infusion of glial cell line-derived neurotrophic factor in PD: a two-year outcome study. Annals of Neurology. 57: 298-302. PMID 15668979 DOI: 10.1002/ana.20374 |
1 |
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| 2005 |
Li J, Spletter ML, Johnson DA, Wright LS, Svendsen CN, Johnson JA. Rotenone-induced caspase 9/3-independent and -dependent cell death in undifferentiated and differentiated human neural stem cells. Journal of Neurochemistry. 92: 462-76. PMID 15659217 DOI: 10.1111/j.1471-4159.2004.02872.x |
1 |
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| 2005 |
Li J, Johnson D, Calkins M, Wright L, Svendsen C, Johnson J. Stabilization of Nrf2 by tBHQ confers protection against oxidative stress-induced cell death in human neural stem cells. Toxicological Sciences : An Official Journal of the Society of Toxicology. 83: 313-28. PMID 15525690 DOI: 10.1093/toxsci/kfi027 |
1 |
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| 2004 |
Ostenfeld T, Svendsen CN. Requirement for neurogenesis to proceed through the division of neuronal progenitors following differentiation of epidermal growth factor and fibroblast growth factor-2-responsive human neural stem cells. Stem Cells (Dayton, Ohio). 22: 798-811. PMID 15342944 DOI: 10.1634/stemcells.22-5-798 |
1 |
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| 2004 |
Behrstock S, Svendsen CN. Combining growth factors, stem cells, and gene therapy for the aging brain. Annals of the New York Academy of Sciences. 1019: 5-14. PMID 15246984 DOI: 10.1196/annals.1297.002 |
1 |
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| 2004 |
Caldwell MA, Garcion E, terBorg MG, He X, Svendsen CN. Heparin stabilizes FGF-2 and modulates striatal precursor cell behavior in response to EGF. Experimental Neurology. 188: 408-20. PMID 15246840 DOI: 10.1016/j.expneurol.2004.05.007 |
1 |
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| 2004 |
McBride JL, Behrstock SP, Chen EY, Jakel RJ, Siegel I, Svendsen CN, Kordower JH. Human neural stem cell transplants improve motor function in a rat model of Huntington's disease. The Journal of Comparative Neurology. 475: 211-9. PMID 15211462 DOI: 10.1002/cne.20176 |
1 |
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| 2004 |
Le Belle JE, Caldwell MA, Svendsen CN. Improving the survival of human CNS precursor-derived neurons after transplantation. Journal of Neuroscience Research. 76: 174-83. PMID 15048915 DOI: 10.1002/jnr.20035 |
1 |
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| 2004 |
Tai YT, Svendsen CN. Stem cells as a potential treatment of neurological disorders. Current Opinion in Pharmacology. 4: 98-104. PMID 15018846 DOI: 10.1016/j.coph.2003.09.006 |
1 |
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| 2004 |
Burnstein RM, Foltynie T, He X, Menon DK, Svendsen CN, Caldwell MA. Differentiation and migration of long term expanded human neural progenitors in a partial lesion model of Parkinson's disease. The International Journal of Biochemistry & Cell Biology. 36: 702-13. PMID 15010333 DOI: 10.1016/j.biocel.2003.11.011 |
1 |
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| 2004 |
Svendsen CN, Langston JW. Stem cells for Parkinson disease and ALS: replacement or protection? Nature Medicine. 10: 224-5. PMID 14991036 DOI: 10.1038/nm0304-224 |
1 |
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| 2004 |
Suzuki M, Wright LS, Marwah P, Lardy HA, Svendsen CN. Mitotic and neurogenic effects of dehydroepiandrosterone (DHEA) on human neural stem cell cultures derived from the fetal cortex. Proceedings of the National Academy of Sciences of the United States of America. 101: 3202-7. PMID 14973190 DOI: 10.1073/pnas.0307325101 |
1 |
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| 2004 |
Jakel RJ, Schneider BL, Svendsen CN. Using human neural stem cells to model neurological disease. Nature Reviews. Genetics. 5: 136-44. PMID 14735124 DOI: 10.1038/nrg1268 |
1 |
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| 2003 |
Chandran S, Kato H, Gerreli D, Compston A, Svendsen CN, Allen ND. FGF-dependent generation of oligodendrocytes by a hedgehog-independent pathway. Development (Cambridge, England). 130: 6599-609. PMID 14660548 DOI: 10.1242/dev.00871 |
1 |
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| 2003 |
Bhattacharyya A, Svendsen CN. Human neural stem cells: a new tool for studying cortical development in Down's syndrome. Genes, Brain, and Behavior. 2: 179-86. PMID 12931791 DOI: 10.1034/j.1601-183X.2003.00025.x |
1 |
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| 2003 |
Wright LS, Li J, Caldwell MA, Wallace K, Johnson JA, Svendsen CN. Gene expression in human neural stem cells: effects of leukemia inhibitory factor. Journal of Neurochemistry. 86: 179-95. PMID 12807438 DOI: 10.1046/j.1471-4159.2003.01826.x |
1 |
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| 2003 |
Gill SS, Patel NK, Hotton GR, O'Sullivan K, McCarter R, Bunnage M, Brooks DJ, Svendsen CN, Heywood P. Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease. Nature Medicine. 9: 589-95. PMID 12669033 DOI: 10.1038/nm850 |
1 |
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| 2003 |
Ostenfeld T, Svendsen CN. Recent advances in stem cell neurobiology. Advances and Technical Standards in Neurosurgery. 28: 3-89. PMID 12627808 |
1 |
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| 2002 |
Le Belle JE, Svendsen CN. Stem cells for neurodegenerative disorders: where can we go from here? Biodrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy. 16: 389-401. PMID 12463763 DOI: 10.2165/00063030-200216060-00001 |
1 |
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| 2002 |
Ostenfeld T, Tai YT, Martin P, Déglon N, Aebischer P, Svendsen CN. Neurospheres modified to produce glial cell line-derived neurotrophic factor increase the survival of transplanted dopamine neurons. Journal of Neuroscience Research. 69: 955-65. PMID 12205689 DOI: 10.1002/jnr.10396 |
1 |
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| 2002 |
Svendsen CN. The amazing astrocyte. Nature. 417: 29-32. PMID 11986650 DOI: 10.1038/417029a |
1 |
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| 2002 |
Ostenfeld T, Joly E, Tai YT, Peters A, Caldwell M, Jauniaux E, Svendsen CN. Regional specification of rodent and human neurospheres. Brain Research. Developmental Brain Research. 134: 43-55. PMID 11947936 DOI: 10.1016/S0165-3806(01)00291-7 |
1 |
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| 2002 |
Wu P, Ye Y, Svendsen CN. Transduction of human neural progenitor cells using recombinant adeno-associated viral vectors. Gene Therapy. 9: 245-55. PMID 11896463 DOI: 10.1038/sj.gt.3301646 |
1 |
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| 2002 |
Bahn S, Mimmack M, Ryan M, Caldwell MA, Jauniaux E, Starkey M, Svendsen CN, Emson P. Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: a gene expression study. Lancet. 359: 310-5. PMID 11830198 DOI: 10.1016/S0140-6736(02)07497-4 |
1 |
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| 2001 |
Svendsen CN, Bhattacharyya A, Tai YT. Neurons from stem cells: preventing an identity crisis. Nature Reviews. Neuroscience. 2: 831-4. PMID 11715059 DOI: 10.1038/35097581 |
1 |
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| 2001 |
Ciccolini F, Svendsen CN. Neurotrophin responsiveness is differentially regulated in neurons and precursors isolated from the developing striatum. Journal of Molecular Neuroscience : Mn. 17: 25-33. PMID 11665860 DOI: 10.1385/JMN:17:1:25 |
1 |
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| 2001 |
Caldwell MA, He X, Wilkie N, Pollack S, Marshall G, Wafford KA, Svendsen CN. Growth factors regulate the survival and fate of cells derived from human neurospheres. Nature Biotechnology. 19: 475-9. PMID 11329020 DOI: 10.1038/88158 |
1 |
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| 2001 |
Björklund A, Svendsen CN. Chimeric stem cells. Trends in Molecular Medicine. 7: 144-6. PMID 11286926 DOI: 10.1016/S1471-4914(01)01980-3 |
1 |
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| 2001 |
McLaren FH, Svendsen CN, Van der Meide P, Joly E. Analysis of neural stem cells by flow cytometry: cellular differentiation modifies patterns of MHC expression. Journal of Neuroimmunology. 112: 35-46. PMID 11108931 DOI: 10.1016/S0165-5728(00)00410-0 |
1 |
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| 2000 |
Armstrong RJE, Watts C, Svendsen CN, Dunnett SB, Rosser AE. Survival, Neuronal Differentiation, and Fiber Outgrowth of Propagated Human Neural Precursor Grafts in an Animal Model of Huntington's Disease. Cell Transplantation. 9: 55-64. PMID 28876110 DOI: 10.1177/096368970000900108 |
1 |
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| 2000 |
Svendsen CN, Caldwell MA. Neural stem cells in the developing central nervous system: implications for cell therapy through transplantation. Progress in Brain Research. 127: 13-34. PMID 11142026 DOI: 10.1016/S0079-6123(00)27003-9 |
1 |
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| 2000 |
Rosser AE, Ostenfeld T, Svendsen CN. Invited commentary: treatment of diseases of the central nervous system using encapsulated cells, by A. F. Hottinger and P. Aebischer (Advances and Technical Standards in Neurosurgery vol. 25). Advances and Technical Standards in Neurosurgery. 26: 125-8. PMID 10997199 |
1 |
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| 2000 |
Ostenfeld T, Caldwell MA, Prowse KR, Linskens MH, Jauniaux E, Svendsen CN. Human neural precursor cells express low levels of telomerase in vitro and show diminishing cell proliferation with extensive axonal outgrowth following transplantation. Experimental Neurology. 164: 215-26. PMID 10877932 DOI: 10.1006/exnr.2000.7427 |
1 |
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| 2000 |
Armstrong RJ, Svendsen CN. Neural stem cells: from cell biology to cell replacement. Cell Transplantation. 9: 139-52. PMID 10811389 |
1 |
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| 2000 |
Armstrong RJ, Watts C, Svendsen CN, Dunnett SB, Rosser AE. Survival, neuronal differentiation, and fiber outgrowth of propagated human neural precursor grafts in an animal model of Huntington's disease. Cell Transplantation. 9: 55-64. PMID 10784067 |
1 |
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| 1999 |
Ostenfeld T, Horn P, Aardal C, Orpen I, Caldwell MA, Svendsen CN. Mouse epidermal growth factor-responsive neural precursor cells increase the survival and functional capacity of embryonic rat dopamine neurons in vitro. Neuroreport. 10: 1985-92. PMID 10501545 |
1 |
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| 1999 |
Kuhn HG, Svendsen CN. Origins, functions, and potential of adult neural stem cells. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 21: 625-30. PMID 10440858 DOI: 10.1002/(SICI)1521-1878(199908)21:8<625::AID-BIES1>3.0.CO;2-6 |
1 |
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| 1999 |
Svendsen CN, Caldwell MA, Ostenfeld T. Human neural stem cells: isolation, expansion and transplantation. Brain Pathology (Zurich, Switzerland). 9: 499-513. PMID 10416990 |
1 |
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| 1999 |
Svendsen CN, Smith AG. New prospects for human stem-cell therapy in the nervous system. Trends in Neurosciences. 22: 357-64. PMID 10407421 DOI: 10.1016/S0166-2236(99)01428-9 |
1 |
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| 1999 |
Bush TG, Puvanachandra N, Horner CH, Polito A, Ostenfeld T, Svendsen CN, Mucke L, Johnson MH, Sofroniew MV. Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice. Neuron. 23: 297-308. PMID 10399936 DOI: 10.1016/S0896-6273(00)80781-3 |
1 |
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| 1999 |
Pearce A, Svendsen CN. Characterisation of stem cell expression using two-dimensional electrophoresis. Electrophoresis. 20: 969-70. PMID 10344273 DOI: 10.1002/(SICI)1522-2683(19990101)20:4/5<969::AID-ELPS969>3.0.CO;2-F |
1 |
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| 1999 |
Bahn S, Wisden W, Dunnett SB, Svendsen C. The intrinsic specification of gamma-aminobutyric acid type A receptor alpha6 subunit gene expression in cerebellar granule cells. The European Journal of Neuroscience. 11: 2194-8. PMID 10336690 DOI: 10.1046/j.1460-9568.1999.00662.x |
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| 1998 |
Svendsen CN, ter Borg MG, Armstrong RJ, Rosser AE, Chandran S, Ostenfeld T, Caldwell MA. A new method for the rapid and long term growth of human neural precursor cells. Journal of Neuroscience Methods. 85: 141-52. PMID 9874150 DOI: 10.1016/S0165-0270(98)00126-5 |
1 |
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| 1998 |
Ciccolini F, Svendsen CN. Fibroblast growth factor 2 (FGF-2) promotes acquisition of epidermal growth factor (EGF) responsiveness in mouse striatal precursor cells: identification of neural precursors responding to both EGF and FGF-2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 7869-80. PMID 9742155 |
1 |
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| 1998 |
Caldwell MA, Svendsen CN. Heparin, but not other proteoglycans potentiates the mitogenic effects of FGF-2 on mesencephalic precursor cells. Experimental Neurology. 152: 1-10. PMID 9682007 DOI: 10.1006/exnr.1998.6815 |
1 |
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| 1998 |
Kimonides VG, Khatibi NH, Svendsen CN, Sofroniew MV, Herbert J. Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 95: 1852-7. PMID 9465106 DOI: 10.1073/pnas.95.4.1852 |
1 |
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| 1997 |
Svendsen CN, Caldwell MA, Shen J, ter Borg MG, Rosser AE, Tyers P, Karmiol S, Dunnett SB. Long-term survival of human central nervous system progenitor cells transplanted into a rat model of Parkinson's disease. Experimental Neurology. 148: 135-46. PMID 9398456 DOI: 10.1006/exnr.1997.6634 |
1 |
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| 1997 |
Svendsen CN, Skepper J, Rosser AE, ter Borg MG, Tyres P, Ryken T. Restricted growth potential of rat neural precursors as compared to mouse. Brain Research. Developmental Brain Research. 99: 253-8. PMID 9125479 DOI: 10.1016/S0165-3806(97)00002-3 |
1 |
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| 1997 |
Rosser AE, Tyers P, ter Borg M, Dunnett SB, Svendsen CN. Co-expression of MAP-2 and GFAP in cells developing from rat EGF responsive precursor cells. Brain Research. Developmental Brain Research. 98: 291-5. PMID 9051273 DOI: 10.1016/S0165-3806(96)00189-7 |
1 |
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| 1997 |
Svendsen CN. Neural stem cells for brain repair Alzheimer's Research. 3: 131-135. |
1 |
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| 1996 |
Sinclair SR, Svendsen CN, Torres EM, Martin D, Fawcett JW, Dunnett SB. GDNF enhances dopaminergic cell survival and fibre outgrowth in embryonic nigral grafts. Neuroreport. 7: 2547-52. PMID 8981421 |
1 |
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| 1996 |
De Lacalle S, Cooper JD, Svendsen CN, Dunnett SB, Sofroniew MV. Reduced retrograde labelling with fluorescent tracer accompanies neuronal atrophy of basal forebrain cholinergic neurons in aged rats. Neuroscience. 75: 19-27. PMID 8923519 DOI: 10.1016/0306-4522(96)00239-4 |
1 |
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| 1996 |
Döbrössy MD, Svendsen CN, Dunnett SB. Bilateral striatal lesions impair retention of an operant test of short-term memory. Brain Research Bulletin. 41: 159-65. PMID 8886385 DOI: 10.1016/S0361-9230(96)00160-8 |
1 |
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| 1996 |
Svendsen CN, Sofroniew MV. Do central nervous system neurons require target-derived neurotrophic support for survival throughout adult life and aging? Perspectives On Developmental Neurobiology. 3: 133-42. PMID 8826531 |
1 |
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| 1996 |
Svendsen CN, Clarke DJ, Rosser AE, Dunnett SB. Survival and differentiation of rat and human epidermal growth factor-responsive precursor cells following grafting into the lesioned adult central nervous system. Experimental Neurology. 137: 376-88. PMID 8635554 DOI: 10.1006/exnr.1996.0039 |
1 |
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| 1995 |
Svendsen CN, Rosser AE. Neurones from stem cells? Trends in Neurosciences. 18: 465-7. PMID 8592748 |
1 |
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| 1995 |
Döbrössy MD, Svendsen CN, Dunnett SB. The effects of bilateral striatal lesions on the acquisition of an operant test of short term memory. Neuroreport. 6: 2049-53. PMID 8580438 |
1 |
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| 1995 |
Svendsen CN, Fawcett JW, Bentlage C, Dunnett SB. Increased survival of rat EGF-generated CNS precursor cells using B27 supplemented medium. Experimental Brain Research. 102: 407-14. PMID 7737387 DOI: 10.1007/BF00230645 |
1 |
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| 1995 |
Svendsen CN, Dunnett SB. When can neural tissue be transplanted? Eye (London, England). 9: 233-5. PMID 7556723 DOI: 10.1038/eye.1995.45 |
1 |
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| 1995 |
Svendsen CN, Dunnett SB. Gene therapy and neural grafting: Keeping the message switched on Behavioral and Brain Sciences. 18: 73-74. DOI: 10.1017/S0140525X00037547 |
0.32 |
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| 1994 |
Svendsen CN, Kew JN, Staley K, Sofroniew MV. Death of developing septal cholinergic neurons following NGF withdrawal in vitro: protection by protein synthesis inhibition. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 75-87. PMID 8283253 |
1 |
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| 1993 |
Dunnett SB, Svendsen CN. Huntington's disease: animal models and transplantation repair. Current Opinion in Neurobiology. 3: 790-6. PMID 8260831 DOI: 10.1016/0959-4388(93)90155-R |
1 |
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| 1993 |
Sofroniew MV, Cooper JD, Svendsen CN, Crossman P, Ip NY, Lindsay RM, Zafra F, Lindholm D. Atrophy but not death of adult septal cholinergic neurons after ablation of target capacity to produce mRNAs for NGF, BDNF, and NT3. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 5263-76. PMID 8254373 |
1 |
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| 1991 |
Stopa EG, Koh ET, Svendsen CN, Rogers WT, Schwaber JS, King JC. Computer-assisted mapping of immunoreactive mammalian gonadotropin-releasing hormone in adult human basal forebrain and amygdala. Endocrinology. 128: 3199-207. PMID 2036986 DOI: 10.1210/endo-128-6-3199 |
1 |
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| 1991 |
Svendsen CN, Cooper JD, Sofroniew MV. Trophic factor effects on septal cholinergic neurons. Annals of the New York Academy of Sciences. 640: 91-4. PMID 1776766 |
1 |
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| 1990 |
O'Brien TS, Svendsen CN, Isacson O, Sofroniew MV. Loss of true blue labelling from the medial septum following transection of the fimbria-fornix: evidence for the death of cholinergic and non-cholinergic neurons. Brain Research. 508: 249-56. PMID 2306616 DOI: 10.1016/0006-8993(90)90403-X |
1 |
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| 1990 |
Sofroniew MV, Galletly NP, Isacson O, Svendsen CN. Survival of adult basal forebrain cholinergic neurons after loss of target neurons. Science (New York, N.Y.). 247: 338-42. PMID 1688664 |
1 |
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| 1988 |
Svendsen CN, Hrbek CC, Casendino M, Nichols RD, Bird ED. Concentration and distribution of thioridazine and metabolites in schizophrenic post-mortem brain tissue. Psychiatry Research. 23: 1-10. PMID 3363012 DOI: 10.1016/0165-1781(88)90029-7 |
1 |
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| 1988 |
Stopa EG, Sower SA, Svendsen CN, King JC. Polygenic expression of gonadotropin-releasing hormone (GnRH) in human? Peptides. 9: 419-23. PMID 3287358 DOI: 10.1016/0196-9781(88)90278-1 |
1 |
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| 1988 |
Svendsen CN, Froimowitz M, Hrbek C, Campbell A, Kula N, Baldessarini RJ, Cohen BM, Babb S, Teicher MH, Bird ED. Receptor affinity, neurochemistry and behavioral characteristics of the enantiomers of thioridazine: evidence for different stereoselectivities at D1 and D2 receptors in rat brain. Neuropharmacology. 27: 1117-24. PMID 2849726 DOI: 10.1016/0028-3908(88)90006-8 |
1 |
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| 1987 |
Beal MF, Svendsen CN, Bird ED, Martin JB. Somatostatin and neuropeptide Y are unaltered in the amygdala in schizophrenia. Neurochemical Pathology. 6: 169-76. PMID 2888067 DOI: 10.1007/BF02834198 |
1 |
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| 1987 |
Jankovic J, Svendsen CN, Bird ED, Eldridge R. Brain neurotransmitters in dystonia New England Journal of Medicine. 316: 278-279. PMID 2879237 |
1 |
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| 1986 |
Beal MF, Mazurek MF, Svendsen CN, Bird ED, Martin JB. Widespread reduction of somatostatin-like immunoreactivity in the cerebral cortex in Alzheimer's disease. Annals of Neurology. 20: 489-95. PMID 3789664 DOI: 10.1002/ana.410200408 |
1 |
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| 1986 |
Beal MF, Mazurek MF, Chattha GK, Svendsen CN, Bird ED, Martin JB. Neuropeptide Y immunoreactivity is reduced in cerebral cortex in Alzheimer's disease. Annals of Neurology. 20: 282-8. PMID 3767313 DOI: 10.1002/ana.410200303 |
1 |
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| 1986 |
Rasool CG, Svendsen CN, Selkoe DJ. Neurofibrillary degeneration of cholinergic and noncholinergic neurons of the basal forebrain in Alzheimer's disease. Annals of Neurology. 20: 482-8. PMID 3539000 DOI: 10.1002/ana.410200407 |
1 |
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| 1986 |
Svendsen CN, Bird ED. HPLC with electrochemical detection to measure chlorpromazine, thioridazine and metabolites in human brain. Psychopharmacology. 90: 316-21. PMID 3097717 DOI: 10.1007/BF00179183 |
1 |
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| 1985 |
Svendsen CN, Bird ED. Acetylcholinesterase staining of the human amygdala. Neuroscience Letters. 54: 313-8. PMID 3991070 |
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