Siddharthan Chandran - Publications

Centre for Brain Reparir, University of Cambridge, UK, Cambridge, England, United Kingdom 
Neural Stem Cell biology

118 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Prudencio M, Humphrey J, Pickles S, Brown AL, Hill SE, Kachergus J, Shi J, Heckman M, Spiegel M, Cook C, Song Y, Yue M, Daughrity L, Carlomagno Y, Jansen-West K, ... ... Chandran S, et al. Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia. The Journal of Clinical Investigation. PMID 32790644 DOI: 10.1172/JCI139741  0.36
2020 Licht-Mayer S, Campbell GR, Canizares M, Mehta AR, Gane AB, McGill K, Ghosh A, Fullerton A, Menezes N, Dean J, Dunham J, Al-Azki S, Pryce G, Zandee S, Zhao C, ... ... Chandran S, et al. Enhanced axonal response of mitochondria to demyelination offers neuroprotection: implications for multiple sclerosis. Acta Neuropathologica. PMID 32572598 DOI: 10.1007/s00401-020-02179-x  0.36
2020 Das Sharma S, Pal R, Reddy BK, Selvaraj BT, Raj N, Samaga KK, Srinivasan DJ, Ornelas L, Sareen D, Livesey MR, Bassell GJ, Svendsen CN, Kind PC, Chandran S, Chattarji S, et al. Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns. Molecular Autism. 11: 52. PMID 32560741 DOI: 10.1186/s13229-020-00351-4  0.72
2020 Toombs J, Panther L, Ornelas L, Liu C, Gomez E, Martín-Ibáñez R, Cox SR, Ritchie SJ, Harris SE, Taylor A, Redmond P, Russ TC, Murphy L, Cooper JD, Burr K, ... ... Chandran S, et al. Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian Birth Cohort 1936. Stem Cell Research. 46: 101851. PMID 32450543 DOI: 10.1016/j.scr.2020.101851  0.72
2020 Bauermeister S, Orton C, Thompson S, Barker RA, Bauermeister JR, Ben-Shlomo Y, Brayne C, Burn D, Campbell A, Calvin C, Chandran S, Chaturvedi N, Chêne G, Chessell IP, Corbett A, et al. The Dementias Platform UK (DPUK) Data Portal. European Journal of Epidemiology. PMID 32328990 DOI: 10.1007/s10654-020-00633-4  0.72
2020 Mehta AR, Selvaraj BT, Barton SK, McDade K, Abrahams S, Chandran S, Smith C, Gregory JM. Improved detection of RNA foci in amyotrophic lateral sclerosis post-mortem tissue using BaseScope™ shows a lack of association with cognitive dysfunction. Brain Communications. 2: fcaa009. PMID 32226938 DOI: 10.1093/braincomms/fcaa009  0.36
2020 Qiu J, Dando O, Febery JA, Fowler JH, Chandran S, Hardingham GE. Neuronal Activity and Its Role in Controlling Antioxidant Genes. International Journal of Molecular Sciences. 21. PMID 32178355 DOI: 10.3390/ijms21061933  0.36
2019 Mehta AR, Walters R, Waldron FM, Pal S, Selvaraj BT, Macleod MR, Hardingham GE, Chandran S, Gregory JM. Targeting mitochondrial dysfunction in amyotrophic lateral sclerosis: a systematic review and meta-analysis. Brain Communications. 1: fcz009. PMID 32133457 DOI: 10.1093/braincomms/fcz009  0.36
2019 Zhao C, Devlin AC, Chouhan AK, Selvaraj BT, Stavrou M, Burr K, Brivio V, He X, Mehta AR, Story D, Shaw CE, Dando O, Hardingham GE, Miles GB, Chandran S. Mutant C9orf72 human iPSC-derived astrocytes cause non-cell autonomous motor neuron pathophysiology. Glia. PMID 31841614 DOI: 10.1002/glia.23761  0.36
2019 Vasistha NA, Johnstone M, Barton SK, Mayerl SE, Thangaraj Selvaraj B, Thomson PA, Dando O, Grünewald E, Alloza C, Bastin ME, Livesey MR, Economides K, Magnani D, Makedonopolou P, Burr K, ... ... Chandran S, et al. Transplanted t(1;11) patient-derived OPCs form shorter myelin internodes in the hypomyelinated shiverer mice. Molecular Psychiatry. 24: 1567. PMID 31645684 DOI: 10.1038/s41380-019-0543-9  0.36
2019 Vasistha NA, Johnstone M, Barton SK, Mayerl SE, Thangaraj Selvaraj B, Thomson PA, Dando O, Grünewald E, Alloza C, Bastin ME, Livesey MR, Economides K, Magnani D, Makedonopolou P, Burr K, ... ... Chandran S, et al. Familial t(1;11) translocation is associated with disruption of white matter structural integrity and oligodendrocyte-myelin dysfunction. Molecular Psychiatry. PMID 31481758 DOI: 10.1038/s41380-019-0505-2  0.36
2019 Magnani D, Chandran S, Wyllie DJA, Livesey MR. In Vitro Generation and Electrophysiological Characterization of OPCs and Oligodendrocytes from Human Pluripotent Stem Cells. Methods in Molecular Biology (Clifton, N.J.). 1936: 65-77. PMID 30820893 DOI: 10.1007/978-1-4939-9072-6_4  0.36
2018 Johnstone M, Vasistha NA, Barbu MC, Dando O, Burr K, Christopher E, Glen S, Robert C, Fetit R, Macleod KG, Livesey MR, Clair DS, Blackwood DHR, Millar K, Carragher NO, ... ... Chandran S, et al. Reversal of proliferation deficits caused by chromosome 16p13.11 microduplication through targeting NFκB signaling: an integrated study of patient-derived neuronal precursor cells, cerebral organoids and in vivo brain imaging. Molecular Psychiatry. PMID 30401811 DOI: 10.1038/s41380-018-0292-1  0.36
2018 Malavasi ELV, Economides KD, Grünewald E, Makedonopoulou P, Gautier P, Mackie S, Murphy LC, Murdoch H, Crummie D, Ogawa F, McCartney DL, O'Sullivan ST, Burr K, Torrance HS, Phillips J, ... ... Chandran S, et al. DISC1 regulates N-methyl-D-aspartate receptor dynamics: abnormalities induced by a Disc1 mutation modelling a translocation linked to major mental illness. Translational Psychiatry. 8: 184. PMID 30190480 DOI: 10.1038/s41398-018-0228-1  0.36
2018 Hasel P, Dando O, Jiwaji Z, Baxter P, Todd AC, Heron S, Márkus NM, McQueen J, Hampton DW, Torvell M, Tiwari SS, McKay S, Eraso-Pichot A, Zorzano A, Masgrau R, ... ... Chandran S, et al. Author Correction: Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism. Nature Communications. 9: 16176. PMID 29405195 DOI: 10.1038/ncomms16176  0.36
2018 Selvaraj BT, Livesey MR, Zhao C, Gregory JM, James OT, Cleary EM, Chouhan AK, Gane AB, Perkins EM, Dando O, Lillico SG, Lee YB, Nishimura AL, Poreci U, Thankamony S, ... ... Chandran S, et al. C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity. Nature Communications. 9: 347. PMID 29367641 DOI: 10.1038/s41467-017-02729-0  0.36
2017 Hasel P, Dando O, Jiwaji Z, Baxter P, Todd AC, Heron S, Márkus NM, McQueen J, Hampton DW, Torvell M, Tiwari SS, McKay S, Eraso-Pichot A, Zorzano A, Masgrau R, ... ... Chandran S, et al. Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism. Nature Communications. 8: 15132. PMID 28462931 DOI: 10.1038/ncomms15132  0.36
2016 Qiu J, McQueen J, Bilican B, Dando O, Magnani D, Punovuori K, Selvaraj BT, Livesey M, Haghi G, Heron S, Burr K, Patani R, Rajan R, Sheppard O, Kind PC, ... ... Chandran S, et al. Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons. Elife. 5. PMID 27692071 DOI: 10.7554/eLife.20337  0.36
2016 McGeachan AJ, Hobson EV, Al-Chalabi A, Stephenson J, Chandran S, Crawley F, Dick D, Donaghy C, Ellis CM, Gorrie G, Hanemann OC, Harrower T, Jung A, Malaspina A, Morrison KE, et al. A multicentre evaluation of oropharyngeal secretion management practices in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 1-9. PMID 27579520 DOI: 10.1080/21678421.2016.1221433  0.88
2016 Sances S, Bruijn LI, Chandran S, Eggan K, Ho R, Klim JR, Livesey MR, Lowry E, Macklis JD, Rushton D, Sadegh C, Sareen D, Wichterle H, Zhang SC, Svendsen CN. Modeling ALS with motor neurons derived from human induced pluripotent stem cells. Nature Neuroscience. 16: 542-53. PMID 27021939 DOI: 10.1038/nn.4273  0.72
2016 Rzechorzek NM, Connick P, Livesey MR, Borooah S, Patani R, Burr K, Story D, Wyllie DJ, Hardingham GE, Chandran S. Hypothermic Preconditioning Reverses Tau Ontogenesis in Human Cortical Neurons and is Mimicked by Protein Phosphatase 2A Inhibition. Ebiomedicine. 3: 141-54. PMID 26870825 DOI: 10.1016/j.ebiom.2015.12.010  0.88
2016 Livesey MR, Magnani D, Cleary EM, Vasistha NA, James OT, Selvaraj BT, Burr K, Story D, Shaw CE, Kind PC, Hardingham GE, Wyllie DJ, Chandran S. Maturation and electrophysiological properties of human pluripotent stem cell-derived oligodendrocytes. Stem Cells (Dayton, Ohio). PMID 26763608 DOI: 10.1002/stem.2273  0.88
2015 Livesey MR, Magnani D, Hardingham GE, Chandran S, Wyllie DJ. Functional properties of in vitro excitatory cortical neurons derived from human pluripotent stem cells. The Journal of Physiology. PMID 26608229 DOI: 10.1113/JP270660  0.88
2015 Rzechorzek NM, Connick P, Patani R, Selvaraj BT, Chandran S. Hypothermic Preconditioning of Human Cortical Neurons Requires Proteostatic Priming. Ebiomedicine. 2: 528-35. PMID 26287272 DOI: 10.1016/j.ebiom.2015.04.004  0.88
2015 Bell KF, Al-Mubarak B, Martel MA, McKay S, Wheelan N, Hasel P, Márkus NM, Baxter P, Deighton RF, Serio A, Bilican B, Chowdhry S, Meakin PJ, Ashford ML, Wyllie DJ, ... ... Chandran S, et al. Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2. Nature Communications. 6: 7066. PMID 25967870 DOI: 10.1038/ncomms8066  0.88
2015 Vesterinen HM, Connick P, Irvine CM, Sena ES, Egan KJ, Carmichael GG, Tariq A, Pavitt S, Chataway J, Macleod MR, Chandran S. Drug repurposing: a systematic approach to evaluate candidate oral neuroprotective interventions for secondary progressive multiple sclerosis. Plos One. 10: e0117705. PMID 25856304 DOI: 10.1371/journal.pone.0117705  0.88
2015 Devlin AC, Burr K, Borooah S, Foster JD, Cleary EM, Geti I, Vallier L, Shaw CE, Chandran S, Miles GB. Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability. Nature Communications. 6: 5999. PMID 25580746 DOI: 10.1038/ncomms6999  0.36
2015 Niven E, Newton J, Foley J, Colville S, Swingler R, Chandran S, Bak TH, Abrahams S. Validation of the Edinburgh Cognitive and Behavioural Amyotrophic Lateral Sclerosis Screen (ECAS): A cognitive tool for motor disorders Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 16: 172-179. DOI: 10.3109/21678421.2015.1030430  0.88
2015 Radakovic R, Stephenson L, Colville S, Swingler R, Chandran S, Abrahams S. Multidimensional apathy in ALS: Validation of the Dimensional Apathy Scale Journal of Neurology, Neurosurgery and Psychiatry. DOI: 10.1136/jnnp-2015-310772  0.88
2014 James OT, Livesey MR, Qiu J, Dando O, Bilican B, Haghi G, Rajan R, Burr K, Hardingham GE, Chandran S, Kind PC, Wyllie DJ. Ionotropic GABA and glycine receptor subunit composition in human pluripotent stem cell-derived excitatory cortical neurones. The Journal of Physiology. 592: 4353-63. PMID 25172951 DOI: 10.1113/jphysiol.2014.278994  0.88
2014 Connick P, Chandran S. Mesenchymal stromal cell transplantation modulates neuroinflammatory milieu in amyotrophic lateral sclerosis. Cytotherapy. 16: 1031-2. PMID 24998167 DOI: 10.1016/j.jcyt.2014.06.001  0.88
2014 Barmada SJ, Serio A, Arjun A, Bilican B, Daub A, Ando DM, Tsvetkov A, Pleiss M, Li X, Peisach D, Shaw C, Chandran S, Finkbeiner S. Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models. Nature Chemical Biology. 10: 677-85. PMID 24974230 DOI: 10.1038/nchembio.1563  0.88
2014 Hunt D, Kavanagh D, Drummond I, Weller B, Bellamy C, Overell J, Evans S, Jackson A, Chandran S. Thrombotic microangiopathy associated with interferon beta. The New England Journal of Medicine. 370: 1270-1. PMID 24670186 DOI: 10.1056/NEJMc1316118  0.88
2014 Nishimura AL, Shum C, Scotter EL, Abdelgany A, Sardone V, Wright J, Lee YB, Chen HJ, Bilican B, Carrasco M, Maniatis T, Chandran S, Rogelj B, Gallo JM, Shaw CE. Allele-specific knockdown of ALS-associated mutant TDP-43 in neural stem cells derived from induced pluripotent stem cells. Plos One. 9: e91269. PMID 24651281 DOI: 10.1371/journal.pone.0091269  0.88
2014 Livesey MR, Bilican B, Qiu J, Rzechorzek NM, Haghi G, Burr K, Hardingham GE, Chandran S, Wyllie DJ. Maturation of AMPAR composition and the GABAAR reversal potential in hPSC-derived cortical neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 4070-5. PMID 24623784 DOI: 10.1523/JNEUROSCI.5410-13.2014  0.88
2014 Alami NH, Smith RB, Carrasco MA, Williams LA, Winborn CS, Han SS, Kiskinis E, Winborn B, Freibaum BD, Kanagaraj A, Clare AJ, Badders NM, Bilican B, Chaum E, Chandran S, et al. Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations. Neuron. 81: 536-43. PMID 24507191 DOI: 10.1016/j.neuron.2013.12.018  0.88
2014 Bilican B, Livesey MR, Haghi G, Qiu J, Burr K, Siller R, Hardingham GE, Wyllie DJ, Chandran S. Physiological normoxia and absence of EGF is required for the long-term propagation of anterior neural precursors from human pluripotent cells. Plos One. 9: e85932. PMID 24465796 DOI: 10.1371/journal.pone.0085932  0.88
2014 Foley P, Lawler A, Chandran S, Mead G. Potential disease-modifying effects of selective serotonin reuptake inhibitors in multiple sclerosis: systematic review and meta-analysis. Journal of Neurology, Neurosurgery, and Psychiatry. 85: 709-10. PMID 24403283 DOI: 10.1136/jnnp-2013-306829  0.88
2013 Hampton DW, Serio A, Pryce G, Al-Izki S, Franklin RJ, Giovannoni G, Baker D, Chandran S. Neurodegeneration progresses despite complete elimination of clinical relapses in a mouse model of multiple sclerosis. Acta Neuropathologica Communications. 1: 84. PMID 24364862 DOI: 10.1186/2051-5960-1-84  0.88
2013 Stacpoole SR, Spitzer S, Bilican B, Compston A, Karadottir R, Chandran S, Franklin RJ. High yields of oligodendrocyte lineage cells from human embryonic stem cells at physiological oxygen tensions for evaluation of translational biology. Stem Cell Reports. 1: 437-50. PMID 24286031 DOI: 10.1016/j.stemcr.2013.09.006  0.88
2013 Borooah S, Phillips MJ, Bilican B, Wright AF, Wilmut I, Chandran S, Gamm D, Dhillon B. Using human induced pluripotent stem cells to treat retinal disease. Progress in Retinal and Eye Research. 37: 163-81. PMID 24104210 DOI: 10.1016/j.preteyeres.2013.09.002  0.88
2013 Bilican B, Serio A, Shaw CE, Maniatis T, Chandran S. Unpicking neurodegeneration in a dish with human pluripotent stem cells: one cell type at a time. Cell Cycle (Georgetown, Tex.). 12: 2339-40. PMID 23856579 DOI: 10.4161/cc.25705  0.88
2013 Bilican B, Serio A, Barmada SJ, Nishimura AL, Sullivan GJ, Carrasco M, Phatnani HP, Puddifoot CA, Story D, Fletcher J, Park IH, Friedman BA, Daley GQ, Wyllie DJ, Hardingham GE, ... ... Chandran S, et al. Comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells". Science Translational Medicine. 5: 188le2. PMID 23740897 DOI: 10.1126/scitranslmed.3005065  0.88
2013 Reimer MM, Norris A, Ohnmacht J, Patani R, Zhong Z, Dias TB, Kuscha V, Scott AL, Chen YC, Rozov S, Frazer SL, Wyatt C, Higashijima S, Patton EE, Panula P, ... Chandran S, et al. Dopamine from the brain promotes spinal motor neuron generation during development and adult regeneration. Developmental Cell. 25: 478-91. PMID 23707737 DOI: 10.1016/j.devcel.2013.04.012  0.88
2013 Stacpoole SR, Webber DJ, Bilican B, Compston A, Chandran S, Franklin RJ. Neural precursor cells cultured at physiologically relevant oxygen tensions have a survival advantage following transplantation. Stem Cells Translational Medicine. 2: 464-72. PMID 23677643 DOI: 10.5966/sctm.2012-0144  0.88
2013 Hobson EV, McGeachan A, Al-Chalabi A, Chandran S, Crawley F, Dick D, Donaghy C, Ealing J, Ellis CM, Gorrie G, Hanemann CO, Harrower T, Jung A, Majeed T, Malaspina A, et al. Management of sialorrhoea in motor neuron disease: a survey of current UK practice. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 14: 521-7. PMID 23647474 DOI: 10.3109/21678421.2013.790452  0.88
2013 Connick P, Chandran S, Bak TH. Patterns of cognitive dysfunction in progressive MS. Behavioural Neurology. 27: 259-65. PMID 23548884 DOI: 10.3233/BEN-120286  0.88
2013 Gupta K, Hardingham GE, Chandran S. NMDA receptor-dependent glutamate excitotoxicity in human embryonic stem cell-derived neurons. Neuroscience Letters. 543: 95-100. PMID 23518152 DOI: 10.1016/j.neulet.2013.03.010  0.88
2013 Serio A, Bilican B, Barmada SJ, Ando DM, Zhao C, Siller R, Burr K, Haghi G, Story D, Nishimura AL, Carrasco MA, Phatnani HP, Shum C, Wilmut I, Maniatis T, ... ... Chandran S, et al. Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy. Proceedings of the National Academy of Sciences of the United States of America. 110: 4697-702. PMID 23401527 DOI: 10.1073/pnas.1300398110  0.88
2013 Foley PL, Vesterinen HM, Laird BJ, Sena ES, Colvin LA, Chandran S, MacLeod MR, Fallon MT. Prevalence and natural history of pain in adults with multiple sclerosis: systematic review and meta-analysis. Pain. 154: 632-42. PMID 23318126 DOI: 10.1016/j.pain.2012.12.002  0.88
2013 Gupta K, Chandran S, Hardingham GE. Human stem cell-derived astrocytes and their application to studying Nrf2-mediated neuroprotective pathways and therapeutics in neurodegeneration. British Journal of Clinical Pharmacology. 75: 907-18. PMID 23126226 DOI: 10.1111/bcp.12022  0.88
2012 Patani R, Chandran S. Experimental and therapeutic opportunities for stem cells in multiple sclerosis. International Journal of Molecular Sciences. 13: 14470-91. PMID 23203076 DOI: 10.3390/ijms131114470  0.88
2012 Yamazaki T, Chen S, Yu Y, Yan B, Haertlein TC, Carrasco MA, Tapia JC, Zhai B, Das R, Lalancette-Hebert M, Sharma A, Chandran S, Sullivan G, Nishimura AL, Shaw CE, et al. FUS-SMN protein interactions link the motor neuron diseases ALS and SMA. Cell Reports. 2: 799-806. PMID 23022481 DOI: 10.1016/j.celrep.2012.08.025  0.88
2012 Patani R, Lewis PA, Trabzuni D, Puddifoot CA, Wyllie DJ, Walker R, Smith C, Hardingham GE, Weale M, Hardy J, Chandran S, Ryten M. Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis. Journal of Neurochemistry. 122: 738-51. PMID 22681703 DOI: 10.1111/j.1471-4159.2012.07825.x  0.88
2012 Bilican B, Serio A, Barmada SJ, Nishimura AL, Sullivan GJ, Carrasco M, Phatnani HP, Puddifoot CA, Story D, Fletcher J, Park IH, Friedman BA, Daley GQ, Wyllie DJ, Hardingham GE, ... ... Chandran S, et al. Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability. Proceedings of the National Academy of Sciences of the United States of America. 109: 5803-8. PMID 22451909 DOI: 10.1073/pnas.1202922109  0.88
2012 Hampton DW, Innes N, Merkler D, Zhao C, Franklin RJ, Chandran S. Focal immune-mediated white matter demyelination reveals an age-associated increase in axonal vulnerability and decreased remyelination efficiency. The American Journal of Pathology. 180: 1897-905. PMID 22426338 DOI: 10.1016/j.ajpath.2012.01.018  0.88
2012 Sajic M, Hunt DP, Lee W, Compston DA, Schweimer JV, Gregson NA, Chandran S, Smith KJ. Mesenchymal stem cells lack efficacy in the treatment of experimental autoimmune neuritis despite in vitro inhibition of T-cell proliferation. Plos One. 7: e30708. PMID 22359549 DOI: 10.1371/journal.pone.0030708  0.88
2012 Patani R, Sibley CR, Chandran S, Ule J. Using human pluripotent stem cells to study post-transcriptional mechanisms of neurodegenerative diseases. Brain Research. 1462: 129-38. PMID 22285437 DOI: 10.1016/j.brainres.2011.12.057  0.88
2012 Connick P, Kolappan M, Crawley C, Webber DJ, Patani R, Michell AW, Du MQ, Luan SL, Altmann DR, Thompson AJ, Compston A, Scott MA, Miller DH, Chandran S. Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study. The Lancet. Neurology. 11: 150-6. PMID 22236384 DOI: 10.1016/S1474-4422(11)70305-2  0.88
2012 Thomson SR, Wishart TM, Patani R, Chandran S, Gillingwater TH. Using induced pluripotent stem cells (iPSC) to model human neuromuscular connectivity: promise or reality? Journal of Anatomy. 220: 122-30. PMID 22133357 DOI: 10.1111/j.1469-7580.2011.01459.x  0.88
2012 Gupta K, Patani R, Baxter P, Serio A, Story D, Tsujita T, Hayes JD, Pedersen RA, Hardingham GE, Chandran S. Human embryonic stem cell derived astrocytes mediate non-cell-autonomous neuroprotection through endogenous and drug-induced mechanisms. Cell Death and Differentiation. 19: 779-87. PMID 22095276 DOI: 10.1038/cdd.2011.154  0.88
2012 Bak TH, Chandran S. What wires together dies together: verbs, actions and neurodegeneration in motor neuron disease. Cortex; a Journal Devoted to the Study of the Nervous System and Behavior. 48: 936-44. PMID 21924711 DOI: 10.1016/j.cortex.2011.07.008  0.88
2012 Connick P, Kolappan M, Bak TH, Chandran S. Verbal fluency as a rapid screening test for cognitive impairment in progressive multiple sclerosis. Journal of Neurology, Neurosurgery, and Psychiatry. 83: 346-7. PMID 21367765 DOI: 10.1136/jnnp.2010.232124  0.88
2011 Stacpoole SR, Bilican B, Webber DJ, Luzhynskaya A, He XL, Compston A, Karadottir R, Franklin RJ, Chandran S. Efficient derivation of NPCs, spinal motor neurons and midbrain dopaminergic neurons from hESCs at 3% oxygen. Nature Protocols. 6: 1229-40. PMID 21799491 DOI: 10.1038/nprot.2011.380  0.88
2011 Ruzov A, Tsenkina Y, Serio A, Dudnakova T, Fletcher J, Bai Y, Chebotareva T, Pells S, Hannoun Z, Sullivan G, Chandran S, Hay DC, Bradley M, Wilmut I, De Sousa P. Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development. Cell Research. 21: 1332-42. PMID 21747414 DOI: 10.1038/cr.2011.113  0.88
2011 Tan CL, Kwok JC, Patani R, Ffrench-Constant C, Chandran S, Fawcett JW. Integrin activation promotes axon growth on inhibitory chondroitin sulfate proteoglycans by enhancing integrin signaling. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 6289-95. PMID 21525268 DOI: 10.1523/JNEUROSCI.0008-11.2011  0.88
2011 Connick P, Kolappan M, Patani R, Scott MA, Crawley C, He XL, Richardson K, Barber K, Webber DJ, Wheeler-Kingshott CA, Tozer DJ, Samson RS, Thomas DL, Du MQ, Luan SL, ... ... Chandran S, et al. The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessments. Trials. 12: 62. PMID 21366911 DOI: 10.1186/1745-6215-12-62  0.88
2011 Patani R, Hollins AJ, Wishart TM, Puddifoot CA, Alvarez S, de Lera AR, Wyllie DJ, Compston DA, Pedersen RA, Gillingwater TH, Hardingham GE, Allen ND, Chandran S. Retinoid-independent motor neurogenesis from human embryonic stem cells reveals a medial columnar ground state. Nature Communications. 2: 214. PMID 21364553 DOI: 10.1038/ncomms1216  0.88
2011 Tollervey JR, Curk T, Rogelj B, Briese M, Cereda M, Kayikci M, König J, Hortobágyi T, Nishimura AL, Zupunski V, Patani R, Chandran S, Rot G, Zupan B, Shaw CE, et al. Characterizing the RNA targets and position-dependent splicing regulation by TDP-43. Nature Neuroscience. 14: 452-8. PMID 21358640 DOI: 10.1038/nn.2778  0.88
2011 Stacpoole SR, Bilican B, Webber DJ, Luzhynskaya A, He XL, Compston A, Karadottir R, Franklin RJ, Chandran S. Derivation of neural precursor cells from human ES cells at 3% O(2) is efficient, enhances survival and presents no barrier to regional specification and functional differentiation. Cell Death and Differentiation. 18: 1016-23. PMID 21274009 DOI: 10.1038/cdd.2010.171  0.88
2011 Connick P, Patani R, Chandran S. Stem cells as a resource for regenerative neurology. Practical Neurology. 11: 29-36. PMID 21239652 DOI: 10.1136/jnnp.2010.235184  0.88
2011 Cordero-Llana O, Scott SA, Maslen SL, Anderson JM, Boyle J, Chowhdury RR, Tyers P, Barker RA, Kelly CM, Rosser AE, Stephens E, Chandran S, Caldwell MA. Clusterin secreted by astrocytes enhances neuronal differentiation from human neural precursor cells. Cell Death and Differentiation. 18: 907-13. PMID 21212797 DOI: 10.1038/cdd.2010.169  0.88
2011 Bell KF, Al-Mubarak B, Fowler JH, Baxter PS, Gupta K, Tsujita T, Chowdhry S, Patani R, Chandran S, Horsburgh K, Hayes JD, Hardingham GE. Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning. Proceedings of the National Academy of Sciences of the United States of America. 108: E1-2; author reply E. PMID 21177433 DOI: 10.1073/pnas.1015229108  0.88
2010 Iovino M, Patani R, Watts C, Chandran S, Spillantini MG. Human stem cell-derived neurons: a system to study human tau function and dysfunction. Plos One. 5: e13947. PMID 21085657 DOI: 10.1371/journal.pone.0013947  0.88
2010 Vesterinen HM, Sena ES, ffrench-Constant C, Williams A, Chandran S, Macleod MR. Improving the translational hit of experimental treatments in multiple sclerosis. Multiple Sclerosis (Houndmills, Basingstoke, England). 16: 1044-55. PMID 20685763 DOI: 10.1177/1352458510379612  0.88
2010 Hampton DW, Webber DJ, Bilican B, Goedert M, Spillantini MG, Chandran S. Cell-mediated neuroprotection in a mouse model of human tauopathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 9973-83. PMID 20668182 DOI: 10.1523/JNEUROSCI.0834-10.2010  0.88
2010 Hardingham GE, Patani R, Baxter P, Wyllie DJ, Chandran S. Human embryonic stem cell-derived neurons as a tool for studying neuroprotection and neurodegeneration. Molecular Neurobiology. 42: 97-102. PMID 20431962 DOI: 10.1007/s12035-010-8136-2  0.88
2010 Anderson JM, Patani R, Reynolds R, Nicholas R, Compston A, Spillantini MG, Chandran S. Abnormal tau phosphorylation in primary progressive multiple sclerosis. Acta Neuropathologica. 119: 591-600. PMID 20306268 DOI: 10.1007/s00401-010-0671-4  0.88
2010 Hunt DP, Sajic M, Phillips H, Henderson D, Compston A, Smith K, Chandran S. Origins of gliogenic stem cell populations within adult skin and bone marrow. Stem Cells and Development. 19: 1055-65. PMID 20102260 DOI: 10.1089/scd.2009.0371  0.88
2009 Chandran S, Naughton GK. Tissue, cell and pathway engineering. Current Opinion in Biotechnology. 20: 509-10. PMID 19897354 DOI: 10.1016/j.copbio.2009.10.014  0.88
2009 Hunt DP, Jahoda C, Chandran S. Multipotent skin-derived precursors: from biology to clinical translation. Current Opinion in Biotechnology. 20: 522-30. PMID 19896826 DOI: 10.1016/j.copbio.2009.10.004  0.88
2009 Webber DJ, van Blitterswijk M, Chandran S. Neuroprotective effect of oligodendrocyte precursor cell transplantation in a long-term model of periventricular leukomalacia. The American Journal of Pathology. 175: 2332-42. PMID 19850891 DOI: 10.2353/ajpath.2009.090051  0.88
2009 Patani R, Compston A, Puddifoot CA, Wyllie DJ, Hardingham GE, Allen ND, Chandran S. Activin/Nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identity. Plos One. 4: e7327. PMID 19806200 DOI: 10.1371/journal.pone.0007327  0.88
2009 Vallier L, Touboul T, Brown S, Cho C, Bilican B, Alexander M, Cedervall J, Chandran S, Ahrlund-Richter L, Weber A, Pedersen RA. Signaling pathways controlling pluripotency and early cell fate decisions of human induced pluripotent stem cells. Stem Cells (Dayton, Ohio). 27: 2655-66. PMID 19688839 DOI: 10.1002/stem.199  0.88
2009 Anderson JM, Patani R, Reynolds R, Nicholas R, Compston A, Spillantini MG, Chandran S. Evidence for abnormal tau phosphorylation in early aggressive multiple sclerosis. Acta Neuropathologica. 117: 583-9. PMID 19288121 DOI: 10.1007/s00401-009-0515-2  0.88
2008 Hunt DP, Irvine KA, Webber DJ, Compston DA, Blakemore WF, Chandran S. Effects of direct transplantation of multipotent mesenchymal stromal/stem cells into the demyelinated spinal cord. Cell Transplantation. 17: 865-73. PMID 19044212 DOI: 10.3727/096368908786516738  0.88
2008 Chandran S. What are the prospects of stem cell therapy for neurology? Bmj (Clinical Research Ed.). 337: a1934. PMID 19042937  0.88
2008 Bilican B, Fiore-Heriche C, Compston A, Allen ND, Chandran S. Induction of Olig2 precursors by FGF involves BMP signalling blockade at the Smad level. Plos One. 3: e2863. PMID 18682850 DOI: 10.1371/journal.pone.0002863  0.88
2008 Hampton DW, Anderson J, Pryce G, Irvine KA, Giovannoni G, Fawcett JW, Compston A, Franklin RJ, Baker D, Chandran S. An experimental model of secondary progressive multiple sclerosis that shows regional variation in gliosis, remyelination, axonal and neuronal loss. Journal of Neuroimmunology. 201: 200-11. PMID 18672298 DOI: 10.1016/j.jneuroim.2008.05.034  0.88
2008 Anderson JM, Hampton DW, Patani R, Pryce G, Crowther RA, Reynolds R, Franklin RJ, Giovannoni G, Compston DA, Baker D, Spillantini MG, Chandran S. Abnormally phosphorylated tau is associated with neuronal and axonal loss in experimental autoimmune encephalomyelitis and multiple sclerosis. Brain : a Journal of Neurology. 131: 1736-48. PMID 18567922 DOI: 10.1093/brain/awn119  0.88
2008 Smith JR, Maguire S, Davis LA, Alexander M, Yang F, Chandran S, ffrench-Constant C, Pedersen RA. Robust, persistent transgene expression in human embryonic stem cells is achieved with AAVS1-targeted integration. Stem Cells (Dayton, Ohio). 26: 496-504. PMID 18024421 DOI: 10.1634/stemcells.2007-0039  0.88
2008 Joannides AJ, Chandran S. Human embryonic stem cells: an experimental and therapeutic resource for neurological disease. Journal of the Neurological Sciences. 265: 84-8. PMID 17920631 DOI: 10.1016/j.jns.2007.09.008  0.88
2008 Hunt DP, Morris PN, Sterling J, Anderson JA, Joannides A, Jahoda C, Compston A, Chandran S. A highly enriched niche of precursor cells with neuronal and glial potential within the hair follicle dermal papilla of adult skin. Stem Cells (Dayton, Ohio). 26: 163-72. PMID 17901404 DOI: 10.1634/stemcells.2007-0281  0.88
2008 Chandran S, Caldwell M, Allen N. Introduction: stem cells and brain repair. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 363: 5-7. PMID 17282994 DOI: 10.1098/rstb.2006.2008  0.88
2008 Chandran S, Hunt D, Joannides A, Zhao C, Compston A, Franklin RJ. Myelin repair: the role of stem and precursor cells in multiple sclerosis. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 363: 171-83. PMID 17282989 DOI: 10.1098/rstb.2006.2019  0.88
2007 Webber DJ, Compston A, Chandran S. Minimally manipulated oligodendrocyte precursor cells retain exclusive commitment to the oligodendrocyte lineage following transplantation into intact and injured hippocampus. The European Journal of Neuroscience. 26: 1791-800. PMID 17897393 DOI: 10.1111/j.1460-9568.2007.05823.x  0.88
2007 Joannides AJ, Webber DJ, Raineteau O, Kelly C, Irvine KA, Watts C, Rosser AE, Kemp PJ, Blakemore WF, Compston A, Caldwell MA, Allen ND, Chandran S. Environmental signals regulate lineage choice and temporal maturation of neural stem cells from human embryonic stem cells. Brain : a Journal of Neurology. 130: 1263-75. PMID 17472984 DOI: 10.1093/brain/awm070  0.88
2007 Joannides AJ, Fiore-Hériché C, Battersby AA, Athauda-Arachchi P, Bouhon IA, Williams L, Westmore K, Kemp PJ, Compston A, Allen ND, Chandran S. A scaleable and defined system for generating neural stem cells from human embryonic stem cells. Stem Cells (Dayton, Ohio). 25: 731-7. PMID 17095704 DOI: 10.1634/stemcells.2006-0562  0.88
2006 Bouhon IA, Joannides A, Kato H, Chandran S, Allen ND. Embryonic stem cell-derived neural progenitors display temporal restriction to neural patterning. Stem Cells (Dayton, Ohio). 24: 1908-13. PMID 16627686 DOI: 10.1634/stemcells.2006-0031  0.88
2006 Gaughwin PM, Caldwell MA, Anderson JM, Schwiening CJ, Fawcett JW, Compston DA, Chandran S. Astrocytes promote neurogenesis from oligodendrocyte precursor cells. The European Journal of Neuroscience. 23: 945-56. PMID 16519659 DOI: 10.1111/j.1460-9568.2006.04625.x  0.88
2006 Joannides A, Fiore-Hériché C, Westmore K, Caldwell M, Compston A, Allen N, Chandran S. Automated mechanical passaging: a novel and efficient method for human embryonic stem cell expansion. Stem Cells (Dayton, Ohio). 24: 230-5. PMID 16510428 DOI: 10.1634/stemcells.2005-0243  0.88
2006 Majed HH, Chandran S, Niclou SP, Nicholas RS, Wilkins A, Wing MG, Rhodes KE, Spillantini MG, Compston A. A novel role for Sema3A in neuroprotection from injury mediated by activated microglia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 1730-8. PMID 16467521 DOI: 10.1523/JNEUROSCI.0702-05.2006  0.88
2005 Bouhon IA, Kato H, Chandran S, Allen ND. Neural differentiation of mouse embryonic stem cells in chemically defined medium. Brain Research Bulletin. 68: 62-75. PMID 16325006 DOI: 10.1016/j.brainresbull.2005.08.022  0.88
2005 Chandran S, Compston A. Neural stem cells as a potential source of oligodendrocytes for myelin repair. Journal of the Neurological Sciences. 233: 179-81. PMID 15907942 DOI: 10.1016/j.jns.2005.03.019  0.88
2005 Phillips JS, King JA, Chandran S, Prinsley PR, Dick D. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) presenting with sudden sensorineural hearing loss. The Journal of Laryngology and Otology. 119: 148-51. PMID 15829071 DOI: 10.1258/0022215053419880  0.88
2004 Chandran S, Compston A, Jauniaux E, Gilson J, Blakemore W, Svendsen C. Differential generation of oligodendrocytes from human and rodent embryonic spinal cord neural precursors. Glia. 47: 314-24. PMID 15293229 DOI: 10.1002/glia.20011  0.88
2004 Joannides A, Gaughwin P, Schwiening C, Majed H, Sterling J, Compston A, Chandran S. Efficient generation of neural precursors from adult human skin: astrocytes promote neurogenesis from skin-derived stem cells. Lancet. 364: 172-8. PMID 15246730 DOI: 10.1016/S0140-6736(04)16630-0  0.88
2004 Chandran S, Caldwell MA. Isolation and Characterization of Stem Cells from the Nervous System Handbook of Stem Cells. 2: 581-591. DOI: 10.1016/B978-012436643-5/50142-5  0.88
2003 Joannides A, Gaughwin P, Scott M, Watt S, Compston A, Chandran S. Postnatal astrocytes promote neural induction from adult human bone marrow-derived stem cells. Journal of Hematotherapy & Stem Cell Research. 12: 681-8. PMID 14977477 DOI: 10.1089/15258160360732704  0.88
2003 Chandran S, Kato H, Gerreli D, Compston A, Svendsen CN, Allen ND. FGF-dependent generation of oligodendrocytes by a hedgehog-independent pathway. Development (Cambridge, England). 130: 6599-609. PMID 14660548 DOI: 10.1242/dev.00871  0.88
2003 Wilkins A, Majed H, Layfield R, Compston A, Chandran S. Oligodendrocytes promote neuronal survival and axonal length by distinct intracellular mechanisms: a novel role for oligodendrocyte-derived glial cell line-derived neurotrophic factor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 4967-74. PMID 12832519  0.88
2003 Zarei M, Chandran S, Compston A, Hodges J. Cognitive presentation of multiple sclerosis: evidence for a cortical variant. Journal of Neurology, Neurosurgery, and Psychiatry. 74: 872-7. PMID 12810770 DOI: 10.1136/jnnp.74.7.872  0.88
2002 Zarei M, Collins VP, Chandran S, Valler D, Higgins JN, Compston DA, Yates JR. Tuberous sclerosis presenting in late adult life. Journal of Neurology, Neurosurgery, and Psychiatry. 73: 436-8. PMID 12235314 DOI: 10.1136/jnnp.73.4.436  0.88
2002 Golde S, Chandran S, Brown GC, Compston A. Different pathways for iNOS-mediated toxicity in vitro dependent on neuronal maturation and NMDA receptor expression. Journal of Neurochemistry. 82: 269-82. PMID 12124428 DOI: 10.1046/j.1471-4159.2002.00973.x  0.88
2001 Wilkins A, Chandran S, Compston A. Sublytic C5b-9-stimulated Schwann cell survival through PI 3-kinase-mediated phosphorylation of BAD Glia. 36: 58-67. PMID 11571784 DOI: 10.1002/glia.1095  0.88
2001 Wilkins A, Chandran S, Compston A. A role for oligodendrocyte-derived IGF-1 in trophic support of cortical neurons. Glia. 36: 48-57. PMID 11571783 DOI: 10.1002/glia.1094  0.48
1998 Svendsen CN, ter Borg MG, Armstrong RJ, Rosser AE, Chandran S, Ostenfeld T, Caldwell MA. A new method for the rapid and long term growth of human neural precursor cells. Journal of Neuroscience Methods. 85: 141-52. PMID 9874150 DOI: 10.1016/S0165-0270(98)00126-5  0.88
1998 Chandran S, Svendsen C, Compston A, Scolding N. Regional potential for oligodendrocyte generation in the rodent embryonic spinal cord following exposure to EGF and FGF-2. Glia. 24: 382-9. PMID 9814818 DOI: 10.1002/(SICI)1098-1136(199812)24:4<382::AID-GLIA3>3.0.CO;2-5  0.88
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