Zheng-Xiong Xi, Ph.D. - Publications

Affiliations: 
Medical College of Wisconsin, Milwaukee, WI, United States 
Area:
Addiction, Neuroimaging

66 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Wang XF, Barbier E, Chiu YT, He Y, Zhan J, Bi GH, Zhang HY, Feng B, Liu-Chen LY, Wang JB, Xi ZX. T394A Mutation at the μ Opioid Receptor Blocks Opioid Tolerance and Increases Vulnerability to Heroin Self-Administration in Mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 10392-10403. PMID 27707973 DOI: 10.1523/JNEUROSCI.0603-16.2016  1
2016 Xi ZX, Song R, Li X, Lu GY, Peng XQ, He Y, Bi GH, Shen P, Yang HJ, Zhang H, Li J, Froimowitz M, Gardner EL. CTDP-32,476: A Promising Agonist Therapy for Treatment of Cocaine Addiction. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27534265 DOI: 10.1038/npp.2016.155  1
2016 Kumar V, Bonifazi A, Ellenberger MP, Keck TM, Pommier E, Rais R, Slusher BS, Gardner E, You ZB, Xi ZX, Newman AH. Highly Selective Dopamine D3 Receptor (D3R) Antagonists and Partial Agonists Based on Eticlopride and the D3R Crystal Structure: New Leads for Opioid Dependence Treatment. Journal of Medicinal Chemistry. PMID 27508895 DOI: 10.1021/acs.jmedchem.6b00860  1
2016 Stempel AV, Stumpf A, Zhang HY, Özdoğan T, Pannasch U, Theis AK, Otte DM, Wojtalla A, Rácz I, Ponomarenko A, Xi ZX, Zimmer A, Schmitz D. Cannabinoid Type 2 Receptors Mediate a Cell Type-Specific Plasticity in the Hippocampus. Neuron. PMID 27133464 DOI: 10.1016/j.neuron.2016.03.034  1
2016 Sushchyk SA, Xi ZX, Wang JB. Combination of levo-tetrahydropalmatine and low dose naltrexone: a promising treatment for the prevention of cocaine relapse. The Journal of Pharmacology and Experimental Therapeutics. PMID 26903543 DOI: 10.1124/jpet.115.229542  1
2014 Zhang HY, Gao M, Liu QR, Bi GH, Li X, Yang HJ, Gardner EL, Wu J, Xi ZX. Cannabinoid CB2 receptors modulate midbrain dopamine neuronal activity and dopamine-related behavior in mice. Proceedings of the National Academy of Sciences of the United States of America. 111: E5007-15. PMID 25368177 DOI: 10.1073/pnas.1413210111  1
2014 Song R, Bi GH, Zhang HY, Yang RF, Gardner EL, Li J, Xi ZX. Blockade of D3 receptors by YQA14 inhibits cocaine's rewarding effects and relapse to drug-seeking behavior in rats. Neuropharmacology. 77: 398-405. PMID 24176392 DOI: 10.1016/j.neuropharm.2013.10.010  1
2014 Keck TM, Zou MF, Bi GH, Zhang HY, Wang XF, Yang HJ, Srivastava R, Gardner EL, Xi ZX, Newman AH. A novel mGluR5 antagonist, MFZ 10-7, inhibits cocaine-taking and cocaine-seeking behavior in rats. Addiction Biology. 19: 195-209. PMID 24001208 DOI: 10.1111/adb.12086  1
2013 Song R, Zhang HY, Peng XQ, Su RB, Yang RF, Li J, Xi ZX, Gardner EL. Dopamine D(3) receptor deletion or blockade attenuates cocaine-induced conditioned place preference in mice. Neuropharmacology. 72: 82-7. PMID 23643749 DOI: 10.1016/j.neuropharm.2013.04.042  1
2013 Keck TM, Yang HJ, Bi GH, Huang Y, Zhang HY, Srivastava R, Gardner EL, Newman AH, Xi ZX. Fenobam sulfate inhibits cocaine-taking and cocaine-seeking behavior in rats: implications for addiction treatment in humans. Psychopharmacology. 229: 253-65. PMID 23615919 DOI: 10.1007/s00213-013-3106-9  1
2013 Xi ZX, Li X, Li J, Peng XQ, Song R, Gaál J, Gardner EL. Blockade of dopamine D3 receptors in the nucleus accumbens and central amygdala inhibits incubation of cocaine craving in rats. Addiction Biology. 18: 665-77. PMID 22913325 DOI: 10.1111/j.1369-1600.2012.00486.x  1
2013 Li X, Xi ZX, Markou A. Metabotropic glutamate 7 (mGlu7) receptor: a target for medication development for the treatment of cocaine dependence. Neuropharmacology. 66: 12-23. PMID 22546614 DOI: 10.1016/j.neuropharm.2012.04.010  1
2012 Song R, Zhang HY, Li X, Bi GH, Gardner EL, Xi ZX. Increased vulnerability to cocaine in mice lacking dopamine D3 receptors. Proceedings of the National Academy of Sciences of the United States of America. 109: 17675-80. PMID 23045656 DOI: 10.1073/pnas.1205297109  1
2012 Srivastava R, Xi ZX, Gardner EL. Cocaine-taking and cocaine-seeking behaviors in rats remain stable after systemic administration of GYKI 52466: a non-competitive AMPA receptor antagonist. Neuroscience Letters. 508: 106-9. PMID 22206835 DOI: 10.1016/j.neulet.2011.12.028  1
2012 Song R, Yang RF, Wu N, Su RB, Li J, Peng XQ, Li X, Gaál J, Xi ZX, Gardner EL. YQA14: a novel dopamine D3 receptor antagonist that inhibits cocaine self-administration in rats and mice, but not in D3 receptor-knockout mice. Addiction Biology. 17: 259-73. PMID 21507153 DOI: 10.1111/j.1369-1600.2011.00317.x  1
2011 Xi ZX, Peng XQ, Li X, Song R, Zhang HY, Liu QR, Yang HJ, Bi GH, Li J, Gardner EL. Brain cannabinoid CB₂ receptors modulate cocaine's actions in mice. Nature Neuroscience. 14: 1160-6. PMID 21785434 DOI: 10.1038/nn.2874  1
2011 Higley AE, Kiefer SW, Li X, Gaál J, Xi ZX, Gardner EL. Dopamine D(3) receptor antagonist SB-277011A inhibits methamphetamine self-administration and methamphetamine-induced reinstatement of drug-seeking in rats. European Journal of Pharmacology. 659: 187-92. PMID 21466803 DOI: 10.1016/j.ejphar.2011.02.046  1
2011 Higley AE, Spiller K, Grundt P, Newman AH, Kiefer SW, Xi ZX, Gardner EL. PG01037, a novel dopamine D3 receptor antagonist, inhibits the effects of methamphetamine in rats. Journal of Psychopharmacology (Oxford, England). 25: 263-73. PMID 20142301 DOI: 10.1177/0269881109358201  1
2010 Peng XQ, Xi ZX, Li X, Spiller K, Li J, Chun L, Wu KM, Froimowitz M, Gardner EL. Is slow-onset long-acting monoamine transport blockade to cocaine as methadone is to heroin? Implication for anti-addiction medications. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 2564-78. PMID 20827272 DOI: 10.1038/npp.2010.133  1
2010 Li X, Li J, Gardner EL, Xi ZX. Activation of mGluR7s inhibits cocaine-induced reinstatement of drug-seeking behavior by a nucleus accumbens glutamate-mGluR2/3 mechanism in rats. Journal of Neurochemistry. 114: 1368-80. PMID 20534005 DOI: 10.1111/j.1471-4159.2010.06851.x  1
2010 Peng XQ, Gardner EL, Xi ZX. Gamma-vinyl GABA increases nonvesicular release of GABA and glutamate in the nucleus accumbens in rats via action on anion channels and GABA transporters. Psychopharmacology. 208: 511-9. PMID 20033132 DOI: 10.1007/s00213-009-1753-7  1
2010 Xi ZX, Li X, Peng XQ, Li J, Chun L, Gardner EL, Thomas AG, Slusher BS, Ashby CR. Inhibition of NAALADase by 2-PMPA attenuates cocaine-induced relapse in rats: a NAAG-mGluR2/3-mediated mechanism. Journal of Neurochemistry. 112: 564-76. PMID 19895667 DOI: 10.1111/j.1471-4159.2009.06478.x  1
2010 Peng XQ, Li J, Gardner EL, Ashby CR, Thomas A, Wozniak K, Slusher BS, Xi ZX. Oral administration of the NAALADase inhibitor GPI-5693 attenuates cocaine-induced reinstatement of drug-seeking behavior in rats. European Journal of Pharmacology. 627: 156-61. PMID 19887067 DOI: 10.1016/j.ejphar.2009.10.062  1
2010 Xi ZX, Kiyatkin M, Li X, Peng XQ, Wiggins A, Spiller K, Li J, Gardner EL. N-acetylaspartylglutamate (NAAG) inhibits intravenous cocaine self-administration and cocaine-enhanced brain-stimulation reward in rats. Neuropharmacology. 58: 304-13. PMID 19559037 DOI: 10.1016/j.neuropharm.2009.06.016  1
2009 Yang S, Salmeron BJ, Ross TJ, Xi ZX, Stein EA, Yang Y. Lower glutamate levels in rostral anterior cingulate of chronic cocaine users - A (1)H-MRS study using TE-averaged PRESS at 3 T with an optimized quantification strategy. Psychiatry Research. 174: 171-6. PMID 19906515 DOI: 10.1016/j.pscychresns.2009.05.004  1
2009 Liu QR, Pan CH, Hishimoto A, Li CY, Xi ZX, Llorente-Berzal A, Viveros MP, Ishiguro H, Arinami T, Onaivi ES, Uhl GR. Species differences in cannabinoid receptor 2 (CNR2 gene): identification of novel human and rodent CB2 isoforms, differential tissue expression and regulation by cannabinoid receptor ligands. Genes, Brain, and Behavior. 8: 519-30. PMID 19496827 DOI: 10.1111/j.1601-183X.2009.00498.x  1
2009 Xi ZX, Spiller K, Gardner EL. Mechanism-based medication development for the treatment of nicotine dependence. Acta Pharmacologica Sinica. 30: 723-39. PMID 19434058 DOI: 10.1038/aps.2009.46  1
2009 Spiller K, Xi ZX, Li X, Ashby CR, Callahan PM, Tehim A, Gardner EL. Varenicline attenuates nicotine-enhanced brain-stimulation reward by activation of alpha4beta2 nicotinic receptors in rats. Neuropharmacology. 57: 60-6. PMID 19393252 DOI: 10.1016/j.neuropharm.2009.04.006  1
2009 Xi ZX, Kleitz HK, Deng X, Ladenheim B, Peng XQ, Li X, Gardner EL, Stein EA, Cadet JL. A single high dose of methamphetamine increases cocaine self-administration by depletion of striatal dopamine in rats. Neuroscience. 161: 392-402. PMID 19336247 DOI: 10.1016/j.neuroscience.2009.03.060  1
2009 Li X, Li J, Peng XQ, Spiller K, Gardner EL, Xi ZX. Metabotropic glutamate receptor 7 modulates the rewarding effects of cocaine in rats: involvement of a ventral pallidal GABAergic mechanism. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 1783-96. PMID 19158667 DOI: 10.1038/npp.2008.236  1
2009 Peng XQ, Ashby CR, Spiller K, Li X, Li J, Thomasson N, Millan MJ, Mocaër E, MuÅ„oz C, Gardner EL, Xi ZX. The preferential dopamine D3 receptor antagonist S33138 inhibits cocaine reward and cocaine-triggered relapse to drug-seeking behavior in rats. Neuropharmacology. 56: 752-60. PMID 19136017 DOI: 10.1016/j.neuropharm.2008.12.007  1
2009 Li X, Hoffman AF, Peng XQ, Lupica CR, Gardner EL, Xi ZX. Attenuation of basal and cocaine-enhanced locomotion and nucleus accumbens dopamine in cannabinoid CB1-receptor-knockout mice. Psychopharmacology. 204: 1-11. PMID 19099297 DOI: 10.1007/s00213-008-1432-0  1
2008 Xi ZX, Gardner EL. Hypothesis-driven medication discovery for the treatment of psychostimulant addiction. Current Drug Abuse Reviews. 1: 303-27. PMID 19430578  1
2008 Li X, Gardner EL, Xi ZX. The metabotropic glutamate receptor 7 (mGluR7) allosteric agonist AMN082 modulates nucleus accumbens GABA and glutamate, but not dopamine, in rats. Neuropharmacology. 54: 542-51. PMID 18155073 DOI: 10.1016/j.neuropharm.2007.11.005  1
2008 Peng XQ, Li X, Li J, Ramachandran PV, Gagare PD, Pratihar D, Ashby CR, Gardner EL, Xi ZX. Effects of gabapentin on cocaine self-administration, cocaine-triggered relapse and cocaine-enhanced nucleus accumbens dopamine in rats. Drug and Alcohol Dependence. 97: 207-15. PMID 18065162 DOI: 10.1016/j.drugalcdep.2007.09.019  1
2008 Peng XQ, Li X, Gilbert JG, Pak AC, Ashby CR, Brodie JD, Dewey SL, Gardner EL, Xi ZX. Gamma-vinyl GABA inhibits cocaine-triggered reinstatement of drug-seeking behavior in rats by a non-dopaminergic mechanism. Drug and Alcohol Dependence. 97: 216-25. PMID 18063319 DOI: 10.1016/j.drugalcdep.2007.10.004  1
2008 Spiller K, Xi ZX, Peng XQ, Newman AH, Ashby CR, Heidbreder C, Gaál J, Gardner EL. The selective dopamine D3 receptor antagonists SB-277011A and NGB 2904 and the putative partial D3 receptor agonist BP-897 attenuate methamphetamine-enhanced brain stimulation reward in rats. Psychopharmacology. 196: 533-42. PMID 17985117 DOI: 10.1007/s00213-007-0986-6  1
2008 Xi ZX, Spiller K, Pak AC, Gilbert J, Dillon C, Li X, Peng XQ, Gardner EL. Cannabinoid CB1 receptor antagonists attenuate cocaine's rewarding effects: experiments with self-administration and brain-stimulation reward in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 1735-45. PMID 17728698 DOI: 10.1038/sj.npp.1301552  1
2007 Xi ZX, Yang Z, Li SJ, Li X, Dillon C, Peng XQ, Spiller K, Gardner EL. Levo-tetrahydropalmatine inhibits cocaine's rewarding effects: experiments with self-administration and brain-stimulation reward in rats. Neuropharmacology. 53: 771-82. PMID 17888459 DOI: 10.1016/j.neuropharm.2007.08.004  1
2007 Xi ZX, Gardner EL. Pharmacological actions of NGB 2904, a selective dopamine D3 receptor antagonist, in animal models of drug addiction. Cns Drug Reviews. 13: 240-59. PMID 17627675 DOI: 10.1111/j.1527-3458.2007.00013.x  1
2007 Lu H, Xi ZX, Gitajn L, Rea W, Yang Y, Stein EA. Cocaine-induced brain activation detected by dynamic manganese-enhanced magnetic resonance imaging (MEMRI). Proceedings of the National Academy of Sciences of the United States of America. 104: 2489-94. PMID 17287361 DOI: 10.1073/pnas.0606983104  0.88
2006 Pak AC, Ashby CR, Heidbreder CA, Pilla M, Gilbert J, Xi ZX, Gardner EL. The selective dopamine D3 receptor antagonist SB-277011A reduces nicotine-enhanced brain reward and nicotine-paired environmental cue functions. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 9: 585-602. PMID 16942635 DOI: 10.1017/S1461145706006560  1
2006 Xi ZX, Gilbert JG, Peng XQ, Pak AC, Li X, Gardner EL. Cannabinoid CB1 receptor antagonist AM251 inhibits cocaine-primed relapse in rats: role of glutamate in the nucleus accumbens. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 8531-6. PMID 16914679 DOI: 10.1523/JNEUROSCI.0726-06.2006  1
2006 Xi ZX, Newman AH, Gilbert JG, Pak AC, Peng XQ, Ashby CR, Gitajn L, Gardner EL. The novel dopamine D3 receptor antagonist NGB 2904 inhibits cocaine's rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 1393-405. PMID 16205781 DOI: 10.1038/sj.npp.1300912  1
2005 Xi ZX, Gilbert JG, Pak AC, Ashby CR, Heidbreder CA, Gardner EL. Selective dopamine D3 receptor antagonism by SB-277011A attenuates cocaine reinforcement as assessed by progressive-ratio and variable-cost-variable-payoff fixed-ratio cocaine self-administration in rats. The European Journal of Neuroscience. 21: 3427-38. PMID 16026480 DOI: 10.1111/j.1460-9568.2005.04159.x  1
2005 Heidbreder CA, Gardner EL, Xi ZX, Thanos PK, Mugnaini M, Hagan JJ, Ashby CR. The role of central dopamine D3 receptors in drug addiction: a review of pharmacological evidence. Brain Research. Brain Research Reviews. 49: 77-105. PMID 15960988 DOI: 10.1016/j.brainresrev.2004.12.033  1
2005 Gilbert JG, Newman AH, Gardner EL, Ashby CR, Heidbreder CA, Pak AC, Peng XQ, Xi ZX. Acute administration of SB-277011A, NGB 2904, or BP 897 inhibits cocaine cue-induced reinstatement of drug-seeking behavior in rats: role of dopamine D3 receptors. Synapse (New York, N.Y.). 57: 17-28. PMID 15858839 DOI: 10.1002/syn.20152  1
2004 Xi ZX, Wu G, Stein EA, Li SJ. Opiate tolerance by heroin self-administration: an fMRI study in rat. Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 52: 108-14. PMID 15236373 DOI: 10.1002/mrm.20119  1
2004 Gorelick DA, Gardner EL, Xi ZX. Agents in development for the management of cocaine abuse. Drugs. 64: 1547-73. PMID 15233592 DOI: 10.2165/00003495-200464140-00004  1
2004 Luo F, Xi ZX, Wu G, Liu C, Gardner EL, Li SJ. Attenuation of brain response to heroin correlates with the reinstatement of heroin-seeking in rats by fMRI. Neuroimage. 22: 1328-35. PMID 15219605 DOI: 10.1016/j.neuroimage.2004.03.017  1
2004 Xi ZX, Gilbert J, Campos AC, Kline N, Ashby CR, Hagan JJ, Heidbreder CA, Gardner EL. Blockade of mesolimbic dopamine D3 receptors inhibits stress-induced reinstatement of cocaine-seeking in rats. Psychopharmacology. 176: 57-65. PMID 15083257 DOI: 10.1007/s00213-004-1858-y  1
2003 Kalivas PW, McFarland K, Bowers S, Szumlinski K, Xi ZX, Baker D. Glutamate transmission and addiction to cocaine. Annals of the New York Academy of Sciences. 1003: 169-75. PMID 14684444 DOI: 10.1196/annals.1300.009  1
2003 Xi ZX, Shen H, Baker DA, Kalivas PW. Inhibition of non-vesicular glutamate release by group III metabotropic glutamate receptors in the nucleus accumbens. Journal of Neurochemistry. 87: 1204-12. PMID 14622100 DOI: 10.1046/j.1471-4159.2003.02093.x  1
2003 Xi ZX, Ramamoorthy S, Shen H, Lake R, Samuvel DJ, Kalivas PW. GABA transmission in the nucleus accumbens is altered after withdrawal from repeated cocaine. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 3498-505. PMID 12716959  1
2003 Xi ZX, Stein EA. Opiate self-administration. Methods in Molecular Medicine. 84: 251-64. PMID 12703330 DOI: 10.1385/1-59259-379-8:251  1
2002 Xi ZX, Wu G, Stein EA, Li SJ. GABAergic mechanisms of heroin-induced brain activation assessed with functional MRI. Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 48: 838-43. PMID 12417998 DOI: 10.1002/mrm.10282  1
2002 Xi ZX, Stein EA. Blockade of ionotropic glutamatergic transmission in the ventral tegmental area reduces heroin reinforcement in rat. Psychopharmacology. 164: 144-50. PMID 12404076 DOI: 10.1007/s00213-002-1190-3  1
2002 Xi ZX, Ramamoorthy S, Baker DA, Shen H, Samuvel DJ, Kalivas PW. Modulation of group II metabotropic glutamate receptor signaling by chronic cocaine. The Journal of Pharmacology and Experimental Therapeutics. 303: 608-15. PMID 12388642 DOI: 10.1124/jpet.102.039735  1
2002 Baker DA, Xi ZX, Shen H, Swanson CJ, Kalivas PW. The origin and neuronal function of in vivo nonsynaptic glutamate. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 9134-41. PMID 12388621  1
2002 Xi ZX, Stein EA. GABAergic mechanisms of opiate reinforcement . Alcohol and Alcoholism (Oxford, Oxfordshire). 37: 485-94. PMID 12217944  0.88
2002 Xi ZX, Baker DA, Shen H, Carson DS, Kalivas PW. Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens. The Journal of Pharmacology and Experimental Therapeutics. 300: 162-71. PMID 11752112 DOI: 10.1124/jpet.300.1.162  1
2000 Xi ZX, Stein EA. Increased mesolimbic GABA concentration blocks heroin self-administration in the rat. The Journal of Pharmacology and Experimental Therapeutics. 294: 613-9. PMID 10900239  1
2000 Xu H, Li SJ, Bodurka J, Zhao X, Xi ZX, Stein EA. Heroin-induced neuronal activation in rat brain assessed by functional MRI. Neuroreport. 11: 1085-92. PMID 10790887  1
1999 Xi ZX, Stein EA. Baclofen inhibits heroin self-administration behavior and mesolimbic dopamine release. The Journal of Pharmacology and Experimental Therapeutics. 290: 1369-74. PMID 10454516  1
1998 Xi ZX, Stein EA. Nucleus accumbens dopamine release modulation by mesolimbic GABAA receptors-an in vivo electrochemical study. Brain Research. 798: 156-65. PMID 9666112 DOI: 10.1016/S0006-8993(98)00406-5  1
1998 Xi ZX, Fuller SA, Stein EA. Dopamine release in the nucleus accumbens during heroin self-administration is modulated by kappa opioid receptors: an in vivo fast-cyclic voltammetry study. The Journal of Pharmacology and Experimental Therapeutics. 284: 151-61. PMID 9435173  1
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