Seungkirl Ahn, Ph.D. - Publications

Affiliations: 
Duke University, Durham, NC 
Area:
G protein-coupled receptors

51 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Liu X, Masoudi A, Kahsai AW, Huang LY, Pani B, Staus DP, Shim PJ, Hirata K, Simhal RK, Schwalb AM, Rambarat PK, Ahn S, Lefkowitz RJ, Kobilka B. Mechanism of βAR regulation by an intracellular positive allosteric modulator. Science (New York, N.Y.). 364: 1283-1287. PMID 31249059 DOI: 10.1126/science.aaw8981  0.64
2018 Luttrell LM, Wang J, Plouffe B, Smith JS, Yamani L, Kaur S, Jean-Charles PY, Gauthier C, Lee MH, Pani B, Kim J, Ahn S, Rajagopal S, Reiter E, Bouvier M, et al. Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9. Science Signaling. 11. PMID 30254056 DOI: 10.1126/scisignal.aat7650  0.64
2018 Choi M, Staus DP, Wingler LM, Ahn S, Pani B, Capel WD, Lefkowitz RJ. G protein-coupled receptor kinases (GRKs) orchestrate biased agonism at the β-adrenergic receptor. Science Signaling. 11. PMID 30131371 DOI: 10.1126/scisignal.aar7084  0.64
2018 Ahn S, Pani B, Kahsai AW, Olsen EK, Husemoen G, Vestrgaard M, Jin L, Zhao S, Wingler LM, Rambarat PK, Simhal RK, Xu TT, Sun LD, Shim PJ, Staus DP, et al. Small Molecule Positive Allosteric Modulators of the β-Adrenoceptor Isolated from DNA Encoded Libraries. Molecular Pharmacology. PMID 29769246 DOI: 10.1124/mol.118.111948  0.64
2018 Meng K, Shim P, Wang Q, Zhao S, Gu T, Kahsai AW, Ahn S, Chen X. Design, synthesis, and functional assessment of Cmpd-15 derivatives as negative allosteric modulators for the β-adrenergic receptor. Bioorganic & Medicinal Chemistry. PMID 29588128 DOI: 10.1016/j.bmc.2018.03.023  0.4
2017 Liu X, Ahn S, Kahsai AW, Meng KC, Latorraca NR, Pani B, Venkatakrishnan AJ, Masoudi A, Weis WI, Dror RO, Chen X, Lefkowitz RJ, Kobilka BK. Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure. Nature. PMID 28813418 DOI: 10.1038/nature23652  0.64
2017 Ahn S, Kahsai AW, Pani B, Wang QT, Zhao S, Wall AL, Strachan RT, Staus DP, Wingler LM, Sun LD, Sinnaeve J, Choi M, Cho T, Xu TT, Hansen GM, et al. Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library. Proceedings of the National Academy of Sciences of the United States of America. PMID 28130548 DOI: 10.1073/pnas.1620645114  0.64
2016 Staus DP, Strachan RT, Manglik A, Pani B, Kahsai AW, Kim TH, Wingler LM, Ahn S, Chatterjee A, Masoudi A, Kruse AC, Pardon E, Steyaert J, Weis WI, Prosser RS, et al. Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation. Nature. PMID 27409812 DOI: 10.1038/nature18636  0.64
2016 Kahsai AW, Wisler JW, Lee J, Ahn S, Cahill Iii TJ, Dennison SM, Staus DP, Thomsen AR, Anasti KM, Pani B, Wingler LM, Desai H, Bompiani KM, Strachan RT, Qin X, et al. Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor. Nature Chemical Biology. PMID 27398998 DOI: 10.1038/nchembio.2126  0.64
2015 Kim BH, Kim DC, Jang MH, Baek J, Park D, Kang IS, Park YC, Ahn S, Cho YH, Kim J, Jeon S. Extraordinary Strong Fluorescence Evolution in Phosphor on Graphene. Advanced Materials (Deerfield Beach, Fla.). PMID 26679004 DOI: 10.1002/adma.201504516  0.48
2015 Lee JH, Ahn SG, Lee JW, Youn YJ, Ahn MS, Kim JY, Yoo BS, Lee SH, Yoon J, Kim J, Choi E, Yoo SY, Hung OY, Samady H. Switching from prasugrel to clopidogrel based on Cytochrome P450 2C19 genotyping in East Asian patients stabilized after acute myocardial infarction. Platelets. 1-7. PMID 26556524 DOI: 10.3109/09537104.2015.1095875  0.48
2015 Kim SY, Herrman A, Song H, Lim TS, Cramer E, Ahn S, Kim J, Ota H, Kim HJ, Kim J. Exploring Cultural Differences in Women's Body Weight Perception: The Impact of Self-Construal on Perceived Overweight and Engagement in Health Activities. Health Care For Women International. 0. PMID 26495754 DOI: 10.1080/07399332.2015.1107070  0.48
2015 Song D, Lee K, Kim EH, Kim YD, Lee HS, Kim J, Song TJ, Ahn SS, Nam HS, Heo JH. Gray-Matter Volume Estimate Score: a Novel Semi-automatic Method Measuring Early Ischemic Change on CT. Journal of Stroke. PMID 26467197 DOI: 10.5853/jos.2015.01298  0.48
2015 Kim MH, Lee YA, Kim J, Park J, Ahn S, Jeon KJ, Kim JW, Choi DK, Seo H. Photochemical Hydrogen Doping Induced Embedded Two-Dimensional Metallic Channel Formation in InGaZnO at Room Temperature. Acs Nano. PMID 26418767 DOI: 10.1021/acsnano.5b05342  0.48
2015 Ahn SH, Kim J, Min HJ, Chung HJ, Hong JM, Lee JG, Kim CH, Cho HJ. Tongue Volume Influences Lowest Oxygen Saturation but Not Apnea-Hypopnea Index in Obstructive Sleep Apnea. Plos One. 10: e0135796. PMID 26280546 DOI: 10.1371/journal.pone.0135796  0.48
2015 Ahn SK, Lee HB, Han W, Moon HG, You JM, Kim J, Han SW, Im SA, Kim TY, Noh DY. Impact of Chemotherapy-Induced Ovarian Dysfunction on Response to Neoadjuvant Chemotherapy in Breast Cancer. Annals of Surgical Oncology. PMID 26275780 DOI: 10.1245/s10434-015-4806-7  0.48
2015 Park M, Lee SK, Choi J, Kim SH, Kim SH, Shin NY, Kim J, Ahn SS. Differentiation between Cystic Pituitary Adenomas and Rathke Cleft Cysts: A Diagnostic Model Using MRI. Ajnr. American Journal of Neuroradiology. PMID 26251436 DOI: 10.3174/ajnr.A4387  0.48
2015 Kim YS, Do H, Lee JW, Jeong J, Shin YW, Yi K, Kim J, Lee SB, Sohn G, Yang N, Oh Y, Kim L, Kim Y, Yu JH, Ko BS, ... ... Ahn SH, et al. Patient reporting pain intensity immediately after surgery can be associated with underlying depression in women with breast cancer. Psycho-Oncology. PMID 26243455 DOI: 10.1002/pon.3919  0.48
2015 Kim BJ, Hwang YH, Ahn S, Ren F, Pearton SJ, Kim J, Jang TS. Effects of 340keV proton irradiation on InGaN/GaN blue light-emitting diodes Journal of Vacuum Science and Technology B: Nanotechnology and Microelectronics. 33. DOI: 10.1116/1.4930297  0.48
2015 Ahn S, Dong C, Zhu W, Kim BJ, Hwang YH, Ren F, Pearton SJ, Yang G, Kim J, Patrick E, Tracy B, Smith DJ, Kravchenko II. Effect of proton irradiation energy on AlGaN/GaN metal-oxide semiconductor high electron mobility transistors Journal of Vacuum Science and Technology B: Nanotechnology and Microelectronics. 33. DOI: 10.1116/1.4928730  0.48
2014 Strachan RT, Sun JP, Rominger DH, Violin JD, Ahn S, Rojas Bie Thomsen A, Zhu X, Kleist A, Costa T, Lefkowitz RJ. Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR). The Journal of Biological Chemistry. 289: 14211-24. PMID 24668815 DOI: 10.1074/jbc.M114.548131  0.64
2014 Staus DP, Wingler LM, Strachan RT, Rasmussen SG, Pardon E, Ahn S, Steyaert J, Kobilka BK, Lefkowitz RJ. Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies. Molecular Pharmacology. 85: 472-81. PMID 24319111 DOI: 10.1124/mol.113.089516  0.64
2013 Aristotelous T, Ahn S, Shukla AK, Gawron S, Sassano MF, Kahsai AW, Wingler LM, Zhu X, Tripathi-Shukla P, Huang XP, Riley J, Besnard J, Read KD, Roth BL, Gilbert IH, et al. Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor. Acs Medicinal Chemistry Letters. 4: 1005-1010. PMID 24454993 DOI: 10.1021/ml400312j  0.64
2013 Weiss DR, Ahn S, Sassano MF, Kleist A, Zhu X, Strachan R, Roth BL, Lefkowitz RJ, Shoichet BK. Conformation guides molecular efficacy in docking screens of activated β-2 adrenergic G protein coupled receptor. Acs Chemical Biology. 8: 1018-26. PMID 23485065 DOI: 10.1021/cb400103f  0.64
2012 Heitzler D, Durand G, Gallay N, Rizk A, Ahn S, Kim J, Violin JD, Dupuy L, Gauthier C, Piketty V, Crépieux P, Poupon A, Clément F, Fages F, Lefkowitz RJ, et al. Competing G protein-coupled receptor kinases balance G protein and β-arrestin signaling. Molecular Systems Biology. 8: 590. PMID 22735336 DOI: 10.1038/msb.2012.22  0.64
2012 Reiter E, Ahn S, Shukla AK, Lefkowitz RJ. Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors. Annual Review of Pharmacology and Toxicology. 52: 179-97. PMID 21942629 DOI: 10.1146/annurev.pharmtox.010909.105800  0.64
2011 Nobles KN, Xiao K, Ahn S, Shukla AK, Lam CM, Rajagopal S, Strachan RT, Huang TY, Bressler EA, Hara MR, Shenoy SK, Gygi SP, Lefkowitz RJ. Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin. Science Signaling. 4: ra51. PMID 21868357 DOI: 10.1126/scisignal.2001707  0.64
2011 Hara MR, Kovacs JJ, Whalen EJ, Rajagopal S, Strachan RT, Grant W, Towers AJ, Williams B, Lam CM, Xiao K, Shenoy SK, Gregory SG, Ahn S, Duckett DR, Lefkowitz RJ. A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1. Nature. 477: 349-53. PMID 21857681 DOI: 10.1038/nature10368  0.64
2011 Kahsai AW, Xiao K, Rajagopal S, Ahn S, Shukla AK, Sun J, Oas TG, Lefkowitz RJ. Multiple ligand-specific conformations of the β2-adrenergic receptor. Nature Chemical Biology. 7: 692-700. PMID 21857662 DOI: 10.1038/nchembio.634  0.64
2011 Rajagopal S, Ahn S, Rominger DH, Gowen-MacDonald W, Lam CM, Dewire SM, Violin JD, Lefkowitz RJ. Quantifying ligand bias at seven-transmembrane receptors. Molecular Pharmacology. 80: 367-77. PMID 21610196 DOI: 10.1124/mol.111.072801  0.64
2010 Shukla AK, Kim J, Ahn S, Xiao K, Shenoy SK, Liedtke W, Lefkowitz RJ. Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4. The Journal of Biological Chemistry. 285: 30115-25. PMID 20650893 DOI: 10.1074/jbc.M110.141549  0.64
2010 Rajagopal S, Kim J, Ahn S, Craig S, Lam CM, Gerard NP, Gerard C, Lefkowitz RJ. Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7. Proceedings of the National Academy of Sciences of the United States of America. 107: 628-32. PMID 20018651 DOI: 10.1073/pnas.0912852107  0.64
2009 Shenoy SK, Modi AS, Shukla AK, Xiao K, Berthouze M, Ahn S, Wilkinson KD, Miller WE, Lefkowitz RJ. Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2. Proceedings of the National Academy of Sciences of the United States of America. 106: 6650-5. PMID 19363159 DOI: 10.1073/pnas.0901083106  0.64
2009 Kim J, Ahn S, Rajagopal K, Lefkowitz RJ. Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor. The Journal of Biological Chemistry. 284: 11953-62. PMID 19254952 DOI: 10.1074/jbc.M808176200  0.64
2009 Ahn S, Kim J, Hara MR, Ren XR, Lefkowitz RJ. {beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation. The Journal of Biological Chemistry. 284: 8855-65. PMID 19171933 DOI: 10.1074/jbc.M808463200  0.64
2008 DeWire SM, Kim J, Whalen EJ, Ahn S, Chen M, Lefkowitz RJ. Beta-arrestin-mediated signaling regulates protein synthesis. The Journal of Biological Chemistry. 283: 10611-20. PMID 18276584 DOI: 10.1074/jbc.M710515200  0.64
2007 Wisler JW, DeWire SM, Whalen EJ, Violin JD, Drake MT, Ahn S, Shenoy SK, Lefkowitz RJ. A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proceedings of the National Academy of Sciences of the United States of America. 104: 16657-62. PMID 17925438 DOI: 10.1073/pnas.0707936104  0.64
2007 Shenoy SK, Barak LS, Xiao K, Ahn S, Berthouze M, Shukla AK, Luttrell LM, Lefkowitz RJ. Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation. The Journal of Biological Chemistry. 282: 29549-62. PMID 17666399 DOI: 10.1074/jbc.M700852200  0.64
2007 DeWire SM, Ahn S, Lefkowitz RJ, Shenoy SK. Beta-arrestins and cell signaling. Annual Review of Physiology. 69: 483-510. PMID 17305471 DOI: 10.1146/annurev.ph.69.013107.100021  0.64
2006 Gesty-Palmer D, Chen M, Reiter E, Ahn S, Nelson CD, Wang S, Eckhardt AE, Cowan CL, Spurney RF, Luttrell LM, Lefkowitz RJ. Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation. The Journal of Biological Chemistry. 281: 10856-64. PMID 16492667 DOI: 10.1074/jbc.M513380200  0.64
2005 Kim J, Ahn S, Ren XR, Whalen EJ, Reiter E, Wei H, Lefkowitz RJ. Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling. Proceedings of the National Academy of Sciences of the United States of America. 102: 1442-7. PMID 15671181 DOI: 10.1073/pnas.0409532102  0.64
2005 Ren XR, Reiter E, Ahn S, Kim J, Chen W, Lefkowitz RJ. Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor. Proceedings of the National Academy of Sciences of the United States of America. 102: 1448-53. PMID 15671180 DOI: 10.1073/pnas.0409534102  0.64
2004 Wei H, Ahn S, Barnes WG, Lefkowitz RJ. Stable interaction between beta-arrestin 2 and angiotensin type 1A receptor is required for beta-arrestin 2-mediated activation of extracellular signal-regulated kinases 1 and 2. The Journal of Biological Chemistry. 279: 48255-61. PMID 15355986 DOI: 10.1074/jbc.M406205200  0.64
2004 Ahn S, Shenoy SK, Wei H, Lefkowitz RJ. Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor. The Journal of Biological Chemistry. 279: 35518-25. PMID 15205453 DOI: 10.1074/jbc.M405878200  0.64
2004 Ahn S, Wei H, Garrison TR, Lefkowitz RJ. Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2. The Journal of Biological Chemistry. 279: 7807-11. PMID 14711824 DOI: 10.1074/jbc.C300443200  0.64
2003 Chen W, ten Berge D, Brown J, Ahn S, Hu LA, Miller WE, Caron MG, Barak LS, Nusse R, Lefkowitz RJ. Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4. Science (New York, N.Y.). 301: 1391-4. PMID 12958364 DOI: 10.1126/science.1082808  0.64
2003 Wei H, Ahn S, Shenoy SK, Karnik SS, Hunyady L, Luttrell LM, Lefkowitz RJ. Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2. Proceedings of the National Academy of Sciences of the United States of America. 100: 10782-7. PMID 12949261 DOI: 10.1073/pnas.1834556100  0.64
2003 Kim J, Ahn S, Guo R, Daaka Y. Regulation of epidermal growth factor receptor internalization by G protein-coupled receptors. Biochemistry. 42: 2887-94. PMID 12627954 DOI: 10.1021/bi026942t  0.48
2003 Ahn S, Nelson CD, Garrison TR, Miller WE, Lefkowitz RJ. Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference. Proceedings of the National Academy of Sciences of the United States of America. 100: 1740-4. PMID 12582207 DOI: 10.1073/pnas.262789099  0.64
2002 Ahn S, Kim J, Lucaveche CL, Reedy MC, Luttrell LM, Lefkowitz RJ, Daaka Y. Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor. The Journal of Biological Chemistry. 277: 26642-51. PMID 12011079 DOI: 10.1074/jbc.M201499200  0.64
2001 Pierce KL, Tohgo A, Ahn S, Field ME, Luttrell LM, Lefkowitz RJ. Epidermal growth factor (EGF) receptor-dependent ERK activation by G protein-coupled receptors: a co-culture system for identifying intermediates upstream and downstream of heparin-binding EGF shedding. The Journal of Biological Chemistry. 276: 23155-60. PMID 11290747 DOI: 10.1074/jbc.M101303200  0.64
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