Christopher B. Kaelin, Ph.D. - Related publications

pigmentation, melanocortin system
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 Li B, Li L, Wang W, Meng J, Xu F, Wu F, Zhang G. Characterization of Free Fatty Acid Receptor 4 and Its Involvement in Nutritional Control and Immune Response in Pacific Oysters (). Acs Omega. 5: 21355-21363. PMID 32905352 DOI: 10.1021/acsomega.0c01325   
2020 Camacho RC, You S, D'Aquino KE, Li W, Wang Y, Gunnet J, Littrell J, Qi JS, Kang L, Jian W, MacDonald M, Tat T, Steiner D, Zhang YM, Lanter J, et al. Conjugation of a peptide to an antibody engineered with free cysteines dramatically improves half-life and activity. Mabs. 12: 1794687. PMID 32744157 DOI: 10.1080/19420862.2020.1794687   
2020 Cao C, Gilbert ER, Cline MA. The anorexigenic effect of beta-melanocyte-stimulating hormone involves corticotrophin-releasing factor and mesotocin in birds. Neuroscience Letters. 135282. PMID 32738351 DOI: 10.1016/j.neulet.2020.135282   
2020 Fernandez RW, Wei K, Wang EY, Mikalauskaite D, Olson A, Pepper J, Christie N, Kim S, Weissenborn S, Sarov M, Koelle MR. Cellular Expression and Functional Roles of All 26 Neurotransmitter GPCRs in the Egg-Laying Circuit. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 32847964 DOI: 10.1523/JNEUROSCI.1357-20.2020   
2020 Li X, Shen L, Hua T, Liu ZJ. Structural and Functional Insights into Cannabinoid Receptors. Trends in Pharmacological Sciences. PMID 32739033 DOI: 10.1016/   
2020 Hankir MK, Seyfried F. Partial Leptin Reduction: An Emerging Weight Loss Paradigm. Trends in Endocrinology and Metabolism: Tem. 31: 395-397. PMID 32396841 DOI: 10.1016/j.tem.2020.03.001   
2020 Duan J, Shen DD, Zhou XE, Bi P, Liu QF, Tan YX, Zhuang YW, Zhang HB, Xu PY, Huang SJ, Ma SS, He XH, Melcher K, Zhang Y, Xu HE, et al. Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy. Nature Communications. 11: 4121. PMID 32807782 DOI: 10.1038/s41467-020-17933-8   
2020 Althumairy D, Zhang X, Baez N, Barisas G, Roess DA, Bousfield GR, Crans DC. Glycoprotein G-protein Coupled Receptors in Disease: Luteinizing Hormone Receptors and Follicle Stimulating Hormone Receptors. Diseases (Basel, Switzerland). 8. PMID 32942611 DOI: 10.3390/diseases8030035   
2020 Ben Haj Salah K, Maingot M, Blayo AL, M'Kadmi C, Damian M, Mary S, Cantel S, Neasta J, Oiry C, Péraldi-Roux S, Fernandez G, Garcia Romero G, Perello M, Marie J, Baneres JL, et al. Development of non-peptidic inverse agonists of the ghrelin receptor (GHSR) based on the 1,2,4-triazole scaffold. Journal of Medicinal Chemistry. PMID 32882134 DOI: 10.1021/acs.jmedchem.9b02122   
2020 Spillmann M, Thurner L, Romantini N, Zimmermann M, Meger B, Behe M, Waldhoer M, Schertler GFX, Berger P. New Insights into Arrestin Recruitment to GPCRs. International Journal of Molecular Sciences. 21. PMID 32668755 DOI: 10.3390/ijms21144949   
2020 Szeto A, Cecati M, Ahmed R, McCabe PM, Mendez AJ. Oxytocin reduces adipose tissue inflammation in obese mice. Lipids in Health and Disease. 19: 188. PMID 32819381 DOI: 10.1186/s12944-020-01364-x   
2020 Zhang J, Li J, Wu C, Hu Z, An L, Wan Y, Fang C, Zhang X, Li J, Wang Y. The Asp298Asn polymorphism of melanocortin-4 receptor (MC4R) in pigs: evidence for its potential effects on MC4R constitutive activity and cell surface expression. Animal Genetics. PMID 32738077 DOI: 10.1111/age.12986   
2020 Lillo A, Martínez-Pinilla E, Reyes-Resina I, Navarro G, Franco R. Adenosine A and A Receptors Are Able to Interact with Each Other. A Further Piece in the Puzzle of Adenosine Receptor-Mediated Signaling. International Journal of Molecular Sciences. 21. PMID 32709103 DOI: 10.3390/ijms21145070   
2020 Sharif E, Al-Wakeel M, Mohamed A, Kerkadi A, Rizk N. Receptor D299G/T399I Haplotype Polymorphism Is Associated with Insulin Resistance in Obese Female Subjects. Genes. 11. PMID 32708841 DOI: 10.3390/genes11070814   
2020 Dengler DG, Sun Q, Holleran J, Pollari S, Beutel J, Brown BT, Shinoki Iwaya A, Ardecky R, Harikumar KG, Miller LJ, Sergienko EA. Development of a Testing Funnel for Identification of Small-Molecule Modulators Targeting Secretin Receptors. Slas Discovery : Advancing Life Sciences R & D. 2472555220945284. PMID 32749201 DOI: 10.1177/2472555220945284   
2020 Waltenspühl Y, Schöppe J, Ehrenmann J, Kummer L, Plückthun A. Crystal structure of the human oxytocin receptor. Science Advances. 6: eabb5419. PMID 32832646 DOI: 10.1126/sciadv.abb5419   
2020 Oliveira da Cruz JF, Ioannidou C, Pagano Zottola AC, Muguruza C, Gomez-Sotres P, Fernandez M, Callado LF, Marsicano G, Busquets-Garcia A. Sex-dependent pharmacological profiles of the synthetic cannabinoid MMB-Fubinaca. Addiction Biology. e12940. PMID 32744799 DOI: 10.1111/adb.12940   
2020 Willard FS, Meredith TD, Showalter AD, Ma W, Ho JD, Sauder JM, Sloop KW. Synthetic protease-activated class B GPCRs. Biochemical and Biophysical Research Communications. 530: 246-251. PMID 32828294 DOI: 10.1016/j.bbrc.2020.07.021   
2020 Silwal P, Paik S, Jeon SM, Jo EK. Nuclear Receptors as Autophagy-Based Antimicrobial Therapeutics. Cells. 9. PMID 32867365 DOI: 10.3390/cells9091979   
2020 Adank DN, Lunzer MM, Ericson MD, Koerperich ZM, Wilber SL, Fleming KA, Haskell-Luevano C. Comparative intracerebroventricular (ICV) and intrathecal (IT) administration of a nanomolar macrocyclic melanocortin receptor agonist MDE6-5-2c (c[Pro-His-DPhe-Arg-Trp-Dap-Ala-DPro]) decreases food intake in mice. Acs Chemical Neuroscience. PMID 32822157 DOI: 10.1021/acschemneuro.0c00409   
2020 Kumar V, Hoag H, Sader S, Scorese N, Liu H, Wu C. GDP Release from the Open Conformation of Gα Requires Allosteric Signaling from the Agonist-Bound Human β Adrenergic Receptor. Journal of Chemical Information and Modeling. PMID 32786510 DOI: 10.1021/acs.jcim.0c00432   
2020 McMahon C, Staus DP, Wingler LM, Wang J, Skiba MA, Elgeti M, Hubbell WL, Rockman HA, Kruse AC, Lefkowitz RJ. Synthetic nanobodies as angiotensin receptor blockers. Proceedings of the National Academy of Sciences of the United States of America. PMID 32753386 DOI: 10.1073/pnas.2009029117   
2020 Uribe-Herranz M, Kuguel SG, Casós K, Costa C. Characterization of putative regulatory isoforms of porcine tumor necrosis factor receptor 2 in endothelial cells. Xenotransplantation. e12635. PMID 32783288 DOI: 10.1111/xen.12635   
2020 Caengprasath N, Gonzalez-Abuin N, Shchepinova M, Ma Y, Inoue A, Tate EW, Frost G, Hanyaloglu AC. Internalization-Dependent Free Fatty Acid Receptor 2 Signaling Is Essential for Propionate-Induced Anorectic Gut Hormone Release. Iscience. 23: 101449. PMID 32853993 DOI: 10.1016/j.isci.2020.101449   
2020 Fang C, Schmaier AH. Novel Anti-Thrombotic Mechanisms Mediated by Mas Receptor as Result of Balanced Activities Between the Kallikrein/Kinin and the Renin-Angiotensin Systems. Pharmacological Research. 105096. PMID 32712319 DOI: 10.1016/j.phrs.2020.105096   
2020 Cifani C, Micioni Di Bonaventura E, Botticelli L, Del Bello F, Giorgioni G, Pavletić P, Piergentili A, Quaglia W, Bonifazi A, Schepmann D, Wünsch B, Vistoli G, Micioni Di Bonaventura MV. Novel Highly Potent and Selective Sigma1 Receptor Antagonists Effectively Blocking the Binge Eating Episode in Female Rats. Acs Chemical Neuroscience. PMID 32886484 DOI: 10.1021/acschemneuro.0c00456   
2020 Gao Z, Song GY, Ren LP, Ma HJ, Ma BQ, Chen SC. β-catenin mediates the effect of GLP-1 receptor agonist on ameliorating hepatic steatosis induced by high fructose diet. European Journal of Histochemistry : Ejh. 64. PMID 32930541 DOI: 10.4081/ejh.2020.3160   
2020 Gao Z, Song GY, Ren LP, Ma HJ, Ma BQ, Chen SC. β-catenin mediates the effect of GLP-1 receptor agonist on ameliorating hepatic steatosis induced by high fructose diet. European Journal of Histochemistry : Ejh. 64. PMID 32930541 DOI: 10.4081/ejh.2020.3160   
2020 Motawe ZY, Abdelmaboud SS, Cuevas J, Breslin JW. PRE-084 as a tool to uncover potential therapeutic applications for selective sigma-1 receptor activation. The International Journal of Biochemistry & Cell Biology. 126: 105803. PMID 32668330 DOI: 10.1016/j.biocel.2020.105803   
2020 Kozma MT, Ngo-Vu H, Rump MT, Bobkov YV, Ache BW, Derby CD. Single cell transcriptomes reveal expression patterns of chemoreceptor genes in olfactory sensory neurons of the Caribbean spiny lobster, Panulirus argus. Bmc Genomics. 21: 649. PMID 32962631 DOI: 10.1186/s12864-020-07034-7   
2020 Wang L, Zhu L, Meister J, Bone DBJ, Pydi SP, Rossi M, Wess J. Use of DREADD Technology to Identify Novel Targets for Antidiabetic Drugs. Annual Review of Pharmacology and Toxicology. PMID 32746768 DOI: 10.1146/annurev-pharmtox-030220-121042   
2020 Gao A, Li L, Yan F, Lei Y, Chen J, Wu L, Ye J. Nile tilapia CXCR4, the receptor of chemokine CXCL12, is involved in host defense against bacterial infection and chemotactic activity. Developmental and Comparative Immunology. 103836. PMID 32835835 DOI: 10.1016/j.dci.2020.103836   
2020 Ellaithy A, Gonzalez-Maeso J, Logothetis DA, Levitz J. Structural and Biophysical Mechanisms of Class C G Protein-Coupled Receptor Function. Trends in Biochemical Sciences. PMID 32861513 DOI: 10.1016/j.tibs.2020.07.008   
2020 Abreu N, Levitz J. Optogenetic Techniques for Manipulating and Sensing G Protein-Coupled Receptor Signaling. Methods in Molecular Biology (Clifton, N.J.). 2173: 21-51. PMID 32651908 DOI: 10.1007/978-1-0716-0755-8_2   
2020 Rijal S, Cho DH, Park SA, Jang SH, Ábrahám IM, Han SK. Melatonin Suppresses the Kainate Receptor-Mediated Excitation on Gonadotropin-Releasing Hormone Neurons in Female and Male Prepubertal Mice. International Journal of Molecular Sciences. 21. PMID 32825350 DOI: 10.3390/ijms21175991   
2020 Nasrollahi-Shirazi S, Szöllösi D, Yang Q, Muratspahic E, El-Kasaby A, Sucic S, Stockner T, Nanoff C, Freissmuth M. Functional Impact of the G279S Substitution in the Adenosine A-Receptor (AR-G279S), a Mutation Associated with Parkinson's Disease. Molecular Pharmacology. 98: 250-266. PMID 32817461 DOI: 10.1124/mol.120.000003   
2020 Han X, Nieman MT. The domino effect triggered by the tethered ligand of the protease activated receptors. Thrombosis Research. 196: 87-98. PMID 32853981 DOI: 10.1016/j.thromres.2020.08.004   
2020 Hughes ME, Mesoy SM, Capes E, Lummis SCR. Many Proline Residues in the Extracellular Domain Contribute to Glycine Receptor Function. Acs Chemical Neuroscience. PMID 32786326 DOI: 10.1021/acschemneuro.0c00320   
2020 Uhelski ML, Bruce D, Speltz R, Wilcox GL, Simone DA. Topical Application of Loperamide/Oxymorphindole, Mu and Delta Opioid Receptor Agonists, Reduces Sensitization of C-fiber Nociceptors that Possess Na1.8. Neuroscience. PMID 32858141 DOI: 10.1016/j.neuroscience.2020.08.022   
2020 Gross KS, Mermelstein PG. Estrogen receptor signaling through metabotropic glutamate receptors. Vitamins and Hormones. 114: 211-232. PMID 32723544 DOI: 10.1016/bs.vh.2020.06.003   
2020 Ho RX, Amraei R, De La Cena KOC, Sutherland EG, Mortazavi F, Stein T, Chitalia V, Rahimi N. Loss of MINAR2 impairs motor function and causes Parkinson's disease-like symptoms in mice. Brain Communications. 2: fcaa047. PMID 32954300 DOI: 10.1093/braincomms/fcaa047   
2020 Drimousis S, Markus I, Murphy TV, Perera DS, Phan-Thien KC, Zhang L, Liu L. Gender-related differences of tachykinin NK receptor expression and activity in human colonic smooth muscle. The Journal of Pharmacology and Experimental Therapeutics. PMID 32764152 DOI: 10.1124/jpet.120.265967   
2020 Qi X, Yoshinari A, Bai P, Maes M, Zeng SM, Torii KU. The manifold actions of signaling peptides on subcellular dynamics of a receptor specify stomatal cell fate. Elife. 9. PMID 32795387 DOI: 10.7554/eLife.58097   
2020 Frégeau G, Sarduy R, Elimam H, Esposito CL, Mellal K, Ménard L, Leitão da Graça SD, Proulx C, Zhang J, Febbraio M, Soto Y, Lubell WD, Ong H, Marleau S. Atheroprotective and atheroregressive potential of azapeptide derivatives of GHRP-6 as selective CD36 ligands in apolipoprotein E-deficient mice. Atherosclerosis. 307: 52-62. PMID 32721647 DOI: 10.1016/j.atherosclerosis.2020.06.010   
2020 Tan W, Zheng H, Wang D, Tian F, Li H, Liu X. Expression characteristics and regulatory mechanism of Apela gene in liver of chicken (Gallus gallus). Plos One. 15: e0238784. PMID 32915867 DOI: 10.1371/journal.pone.0238784   
2020 Krieger K, Wängler B, Schirrmacher R, Wängler C. Identification of a suitable peptidic molecular platform for the development of NPY(Y1)R-specific imaging agents. Chemmedchem. PMID 32681597 DOI: 10.1002/cmdc.202000430   
2020 Penthala NR, Shoeib A, Dachavaram SS, Cabanlong CV, Yang J, Zhan CG, Prather PL, Crooks PA. 7-Azaindolequinuclidinones (7-AIQD): A novel class of cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptor ligands. Bioorganic & Medicinal Chemistry Letters. 30: 127501. PMID 32882418 DOI: 10.1016/j.bmcl.2020.127501   
2020 Liu H, Yi P, Zhao W, Wu Y, Acher F, Pin JP, Liu J, Rondard P. Illuminating the allosteric modulation of the calcium-sensing receptor. Proceedings of the National Academy of Sciences of the United States of America. PMID 32817431 DOI: 10.1073/pnas.1922231117   
2020 Shiimura Y, Horita S, Hamamoto A, Asada H, Hirata K, Tanaka M, Mori K, Uemura T, Kobayashi T, Iwata S, Kojima M. Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode. Nature Communications. 11: 4160. PMID 32814772 DOI: 10.1038/s41467-020-17554-1   
2020 Zhang S, Gong H, Ge Y, Ye RD. Biased allosteric modulation of formyl peptide receptor 2 leads to distinct receptor conformational states for pro- and anti-inflammatory signaling. Pharmacological Research. 105117. PMID 32768626 DOI: 10.1016/j.phrs.2020.105117