Ruwanthi N. Gunawardane, Ph.D. - Publications

Institution:
Johns Hopkins University, Baltimore, MD
Area:
Cell biology

6/31 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2003 Gunawardane RN, Martin OC, Zheng Y. Characterization of a new gammaTuRC subunit with WD repeats. Molecular Biology of the Cell. 14: 1017-26. PMID 12631720 DOI: 10.1091/Mbc.E02-01-0034  0.71
2001 Gunawardane RN, Zheng Y, Oegema K, Wiese C. Purification and reconstitution of Drosophila gamma-tubulin complexes. Methods in Cell Biology. 67: 1-25. PMID 11550462 DOI: 10.1016/S0091-679X(01)67002-X  0.649
2001 Gunawardane RN, Zheng Y, Oegema K, Wiese C. Purification and reconstitution of Drosophila γ-tubulin complexes Methods in Cell Biology. 1-25.  0.562
2000 Gunawardane RN, Martin OC, Cao K, Zhang L, Dej K, Iwamatsu A, Zheng Y. Characterization and reconstitution of Drosophila gamma-tubulin ring complex subunits. The Journal of Cell Biology. 151: 1513-24. PMID 11134079 DOI: 10.1083/Jcb.151.7.1513  0.678
2000 Gunawardane RN, Lizarraga SB, Wiese C, Wilde A, Zheng Y. gamma-Tubulin complexes and their role in microtubule nucleation. Current Topics in Developmental Biology. 49: 55-73. PMID 11005014 DOI: 10.1016/S0070-2153(99)49004-0  0.565
1998 Martin OC, Gunawardane RN, Iwamatsu A, Zheng Y. Xgrip109: a gamma tubulin-associated protein with an essential role in gamma tubulin ring complex (gammaTuRC) assembly and centrosome function. The Journal of Cell Biology. 141: 675-87. PMID 9566968 DOI: 10.1083/Jcb.141.3.675  0.718
Low-probability matches (unlikely to be authored by this person)
2017 Roberts B, Haupt A, Tucker A, Grancharova T, Arakaki J, Fuqua MA, Nelson A, Hookway C, Ludmann SA, Mueller IA, Yang R, Horwitz AR, Rafelski SM, Gunawardane RN. Systematic gene tagging using CRISPR/Cas9 in human stem cells to illuminate cell organization. Molecular Biology of the Cell. PMID 28814507 DOI: 10.1091/mbc.E17-03-0209  0.241
2015 Piper DE, Romanow WG, Gunawardane RN, Fordstrom P, Masterman S, Pan O, Thibault ST, Zhang R, Meininger D, Schwarz M, Wang Z, King C, Zhou M, Walker NP. The high resolution crystal structure of human LCAT. Journal of Lipid Research. PMID 26195816 DOI: 10.1194/jlr.M059873  0.225
2018 Haupt A, Grancharova T, Arakaki J, Fuqua MA, Roberts B, Gunawardane RN. Endogenous Protein Tagging in Human Induced Pluripotent Stem Cells Using CRISPR/Cas9. Journal of Visualized Experiments : Jove. PMID 30199041 DOI: 10.3791/58130  0.225
2023 Viana MP, Chen J, Knijnenburg TA, Vasan R, Yan C, Arakaki JE, Bailey M, Berry B, Borensztejn A, Brown EM, Carlson S, Cass JA, Chaudhuri B, Cordes Metzler KR, Coston ME, ... ... Gunawardane RN, et al. Integrated intracellular organization and its variations in human iPS cells. Nature. PMID 36599983 DOI: 10.1038/s41586-022-05563-7  0.215
2006 Witt AE, Hines LM, Collins NL, Hu Y, Gunawardane RN, Moreira D, Raphael J, Jepson D, Koundinya M, Rolfs A, Taron B, Isakoff SJ, Brugge JS, LaBaer J. Functional proteomics approach to investigate the biological activities of cDNAs implicated in breast cancer. Journal of Proteome Research. 5: 599-610. PMID 16512675 DOI: 10.1021/Pr050395R  0.197
2019 Roberts B, Hendershott MC, Arakaki J, Gerbin KA, Malik H, Nelson A, Gehring J, Hookway C, Ludmann SA, Yang R, Haupt A, Grancharova T, Valencia V, Fuqua MA, Tucker A, ... ... Gunawardane RN, et al. Fluorescent Gene Tagging of Transcriptionally Silent Genes in hiPSCs. Stem Cell Reports. PMID 30956114 DOI: 10.1016/j.stemcr.2019.03.001  0.153
2021 Gerbin KA, Grancharova T, Donovan-Maiye RM, Hendershott MC, Anderson HG, Brown JM, Chen J, Dinh SQ, Gehring JL, Johnson GR, Lee H, Nath A, Nelson AM, Sluzewski MF, Viana MP, ... ... Gunawardane RN, et al. Cell states beyond transcriptomics: Integrating structural organization and gene expression in hiPSC-derived cardiomyocytes. Cell Systems. PMID 34043964 DOI: 10.1016/j.cels.2021.05.001  0.15
2015 Gunawardane RN, Fordstrom P, Piper DE, Masterman S, Siu S, Liu D, Brown M, Lu M, Tang J, Zhang R, Cheng J, Gates A, Meininger D, Chan J, Carlson T, et al. Agonistic Human Antibodies Binding To Lecithin-Cholesterol Acyltransferase Modulate High Density Lipoprotein Metabolism. The Journal of Biological Chemistry. PMID 26644477 DOI: 10.1074/jbc.M115.672790  0.137
2023 Gregor BW, Coston ME, Adams EM, Arakaki J, Borensztejn A, Do TP, Fuqua MA, Haupt A, Hendershott MC, Leung W, Mueller IA, Nath A, Nelson AM, Rafelski SM, Sanchez EE, ... ... Gunawardane RN, et al. Automated human induced pluripotent stem cell culture and sample preparation for 3D live-cell microscopy. Nature Protocols. PMID 38087082 DOI: 10.1038/s41596-023-00912-w  0.132
2012 Rowbottom MW, Faraoni R, Chao Q, Campbell BT, Lai AG, Setti E, Ezawa M, Sprankle KG, Abraham S, Tran L, Struss B, Gibney M, Armstrong RC, Gunawardane RN, Nepomuceno RR, et al. Identification of 1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea hydrochloride (CEP-32496), a highly potent and orally efficacious inhibitor of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF) V600E. Journal of Medicinal Chemistry. 55: 1082-105. PMID 22168626 DOI: 10.1021/jm2009925  0.112
2012 Liu G, Abraham S, Tran L, Vickers TD, Xu S, Hadd MJ, Quiambao S, Holladay MW, Hua H, Ford Pulido JM, Gunawardane RN, Davis MI, Eichelberger SR, Apuy JL, Gitnick D, et al. Discovery of highly potent and selective pan-Aurora kinase inhibitors with enhanced in vivo antitumor therapeutic index. Journal of Medicinal Chemistry. 55: 3250-60. PMID 22380736 DOI: 10.1021/Jm201702G  0.109
2023 Lee S, Roest ASV, Blair CA, Kao K, Bremner SB, Childers MC, Pathak D, Heinrich P, Lee D, Chirikian O, Mohran S, Roberts B, Smith JE, Jahng JW, Paik DT, ... ... Gunawardane RN, et al. Multi-scale models reveal hypertrophic cardiomyopathy MYH7 G256E mutation drives hypercontractility and elevated mitochondrial respiration. Biorxiv : the Preprint Server For Biology. PMID 37333118 DOI: 10.1101/2023.06.08.544276  0.107
2010 Wolfer A, Wittner BS, Irimia D, Flavin RJ, Lupien M, Gunawardane RN, Meyer CA, Lightcap ES, Tamayo P, Mesirov JP, Liu XS, Shioda T, Toner M, Loda M, Brown M, et al. MYC regulation of a "poor-prognosis" metastatic cancer cell state. Proceedings of the National Academy of Sciences of the United States of America. 107: 3698-703. PMID 20133671 DOI: 10.1073/Pnas.0914203107  0.107
2005 Gunawardane RN, Sgroi DC, Wrobel CN, Koh E, Daley GQ, Brugge JS. Novel role for PDEF in epithelial cell migration and invasion. Cancer Research. 65: 11572-80. PMID 16357167 DOI: 10.1158/0008-5472.Can-05-1196  0.097
2012 James J, Ruggeri B, Armstrong RC, Rowbottom MW, Jones-Bolin S, Gunawardane RN, Dobrzanski P, Gardner MF, Zhao H, Cramer MD, Hunter K, Nepomuceno RR, Cheng M, Gitnick D, Yazdanian M, et al. CEP-32496: a novel orally active BRAF(V600E) inhibitor with selective cellular and in vivo antitumor activity. Molecular Cancer Therapeutics. 11: 930-41. PMID 22319199 DOI: 10.1158/1535-7163.MCT-11-0645  0.093
2013 Gunawardane RN, Nepomuceno RR, Rooks AM, Hunt JP, Ricono JM, Belli B, Armstrong RC. Transient exposure to quizartinib mediates sustained inhibition of FLT3 signaling while specifically inducing apoptosis in FLT3-activated leukemia cells. Molecular Cancer Therapeutics. 12: 438-47. PMID 23412931 DOI: 10.1158/1535-7163.MCT-12-0305  0.092
2011 Holladay MW, Campbell BT, Rowbottom MW, Chao Q, Sprankle KG, Lai AG, Abraham S, Setti E, Faraoni R, Tran L, Armstrong RC, Gunawardane RN, Gardner MF, Cramer MD, Gitnick D, et al. 4-Quinazolinyloxy-diaryl ureas as novel BRAFV600E inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 5342-6. PMID 21807507 DOI: 10.1016/j.bmcl.2011.07.019  0.085
2008 Zarrinkar PP, Armstrong RC, Gunawardane RN, James J, Karaman MW, Bhagwat SS. AC220 Is a Uniquely Potent and Selective Second-Generation FLT3 Inhibitor Blood. 112: 859-859. DOI: 10.1182/blood.v112.11.859.859  0.06
2021 Grancharova T, Gerbin KA, Rosenberg AB, Roco CM, Arakaki JE, DeLizo CM, Dinh SQ, Donovan-Maiye RM, Hirano M, Nelson AM, Tang J, Theriot JA, Yan C, Menon V, Palecek SP, ... ... Gunawardane RN, et al. A comprehensive analysis of gene expression changes in a high replicate and open-source dataset of differentiating hiPSC-derived cardiomyocytes. Scientific Reports. 11: 15845. PMID 34349150 DOI: 10.1038/s41598-021-94732-1  0.053
2011 Nepomuceno RR, Gunawardane R, Rooks AM, Armstrong RC. Detection of Phosphorylated and Total Flt3 and STAT5 in Whole Blood: Modulation by AC220 From Phase I and II Trials in AML Blood. 118: 2607-2607. DOI: 10.1182/blood.V118.21.2607.2607  0.051
2013 Buchwalter G, Hickey MM, Cromer A, Selfors LM, Gunawardane RN, Frishman J, Jeselsohn R, Lim E, Chi D, Fu X, Schiff R, Brown M, Brugge JS. PDEF promotes luminal differentiation and acts as a survival factor for ER-positive breast cancer cells. Cancer Cell. 23: 753-67. PMID 23764000 DOI: 10.1016/J.Ccr.2013.04.026  0.046
2009 Chao Q, Sprankle KG, Grotzfeld RM, Lai AG, Carter TA, Velasco AM, Gunawardane RN, Cramer MD, Gardner MF, James J, Zarrinkar PP, Patel HK, Bhagwat SS. Identification of N-(5-tert-butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea dihydrochloride (AC220), a uniquely potent, selective, and efficacious FMS-like tyrosine kinase-3 (FLT3) inhibitor. Journal of Medicinal Chemistry. 52: 7808-16. PMID 19754199 DOI: 10.1021/Jm9007533  0.038
2021 Horwitz R, Riley EAU, Millan MT, Gunawardane RN. It's time to incorporate diversity into our basic science and disease models. Nature Cell Biology. 23: 1213-1214. PMID 34845353 DOI: 10.1038/s41556-021-00803-w  0.037
2009 Cortes J, Foran J, Ghirdaladze D, DeVetten MP, Zodelava M, Holman P, Levis MJ, Kantarjian HM, Borthakur G, James J, Zarringkar PP, Gunawardane RN, Armstrong RC, Padre NM, Wierenga W, et al. AC220, a Potent, Selective, Second Generation FLT3 Receptor Tyrosine Kinase (RTK) Inhibitor, in a First-in-Human (FIH) Phase 1 AML Study. Blood. 114: 636-636. DOI: 10.1182/blood.V114.22.636.636  0.027
2009 Zarrinkar PP, Gunawardane RN, Cramer MD, Gardner MF, Brigham D, Belli B, Karaman MW, Pratz KW, Pallares G, Chao Q, Sprankle KG, Patel HK, Levis M, Armstrong RC, James J, et al. AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). Blood. 114: 2984-92. PMID 19654408 DOI: 10.1182/blood-2009-05-222034  0.011
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