Karl Tsim - Publications

Affiliations: 
HKUST, Newark, New Territories, Hong Kong 
Area:
AChE, neuromuscular junctions

292 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Wang HY, Guo SC, Peng ZT, Wang C, Duan R, Dong TTX, Tsim KWK. Polysaccharide Promotes the In Vitro Metabolism of Ophiopogonins by Human Gut Microbiota. Molecules (Basel, Switzerland). 24. PMID 31398918 DOI: 10.3390/molecules24162886  0.56
2019 Wang HY, Wang C, Guo SC, Chen ZC, Peng ZT, Duan R, Dong TTX, Tsim KWK. Polysaccharide deriving from Ophiopogonis Radix promotes metabolism of ginsenosides in the present of human gut microbiota based on UPLC-MS/MS assay. Journal of Pharmaceutical and Biomedical Analysis. 175: 112779. PMID 31349212 DOI: 10.1016/j.jpba.2019.112779  0.56
2019 Gong G, Han G, He H, Dong TTX, Tsim KWK, Zheng Y. An Ancient Chinese Herbal Decoction Containing Angelicae Sinensis Radix, Astragali Radix, Jujuba Fructus, and Zingiberis Rhizoma Recens Stimulates the Browning Conversion of White Adipocyte in Cultured 3T3-L1 Cells. Evidence-Based Complementary and Alternative Medicine : Ecam. 2019: 3648685. PMID 31316571 DOI: 10.1155/2019/3648685  0.56
2019 Kwan KKL, Huang Y, Leung KW, Dong TTX, Tsim KWK. Danggui Buxue Tang, a Chinese Herbal Decoction Containing Astragali Radix and Angelicae Sinensis Radix, Modulates Mitochondrial Bioenergetics in Cultured Cardiomyoblasts. Frontiers in Pharmacology. 10: 614. PMID 31316376 DOI: 10.3389/fphar.2019.00614  0.56
2019 Xu ML, Luk WKW, Liu EYL, Kong XP, Wu QY, Xia YJ, Dong TTX, Tsim KWK. Differentiation of erythroblast requires the dimeric form of acetylcholinesterase: Interference with erythropoietin receptor. Chemico-Biological Interactions. PMID 31170385 DOI: 10.1016/j.cbi.2019.06.006  0.56
2019 Lam KYC, Wu QY, Hu WH, Yao P, Wang HY, Dong TTX, Tsim KWK. Asarones from Acori Tatarinowii Rhizoma stimulate expression and secretion of neurotrophic factors in cultured astrocytes. Neuroscience Letters. 134308. PMID 31153972 DOI: 10.1016/j.neulet.2019.134308  0.56
2019 Wang HY, Wang C, Guo LX, Zheng YF, Hu WH, Dong TTX, Wang TJ, Tsim KWK. Simultaneous determination of short-chain fatty acids in human feces by HPLC with ultraviolet detection following chemical derivatization and solid-phase extraction segmental elution. Journal of Separation Science. PMID 31115147 DOI: 10.1002/jssc.201900249  0.56
2019 Liu EYL, Xu ML, Xia Y, Kong X, Wu Q, Dong TTX, Tsim KWK. Activation of G protein-coupled receptor 30 by flavonoids leads to expression of acetylcholinesterase in cultured PC12 cells. Chemico-Biological Interactions. PMID 31034797 DOI: 10.1016/j.cbi.2019.04.031  0.56
2019 Yang M, Han R, Ni LY, Luo XC, Li AX, Dan XM, Tsim KW, Li YW. Molecular characteristics and function study of TNF receptor-associated factor 5 from grouper (Epinephelus coioides). Fish & Shellfish Immunology. PMID 30769079 DOI: 10.1016/j.fsi.2019.02.018  0.32
2019 Gong G, Qi B, Liang YT, Dong TTX, Wang HY, Tsim KWK, Zheng Y. Danggui Buxue Tang, an ancient Chinese herbal decoction, protects β-amyloid-induced cell death in cultured cortical neurons. Bmc Complementary and Alternative Medicine. 19: 9. PMID 30621672 DOI: 10.1186/s12906-018-2411-6  0.56
2018 Huang Y, Yao P, Leung KW, Wang H, Kong XP, Dong TTX, Chen Y, Qin QW, Tsim KWK. The Chinese medicinal herbs of spleen-meridian property regulate body temperature in yeast-induced fever rats. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. 152815. PMID 30833146 DOI: 10.1016/j.phymed.2018.12.038  0.56
2018 Wu QY, Wong ZC, Wang C, Fung AH, Wong EO, Chan GK, Dong TT, Chen Y, Tsim KW. Isoorientin derived from Gentiana veitchiorum Hemsl. flowers inhibits melanogenesis by down-regulating MITF-induced tyrosinase expression. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. 57: 129-136. PMID 30668315 DOI: 10.1016/j.phymed.2018.12.006  0.48
2018 Hu W, Duan RR, Xia Y, Xiong Q, Wang H, Kar-Lun Chan G, Liu S, Dong TTX, Qin Q, Tsim KWK. The binding of resveratrol to vascular endothelial growth factor (VEGF) suppresses angiogenesis by inhibiting the receptor signalling. Journal of Agricultural and Food Chemistry. PMID 30525561 DOI: 10.1021/acs.jafc.8b05977  0.56
2018 Huang Y, Yao P, Leung KW, Wang H, Kong XP, Wang L, Dong TTX, Chen Y, Tsim KWK. The Yin-Yang Property of Chinese Medicinal Herbs Relates to Chemical Composition but Not Anti-Oxidative Activity: An Illustration Using Spleen-Meridian Herbs. Frontiers in Pharmacology. 9: 1304. PMID 30498446 DOI: 10.3389/fphar.2018.01304  0.56
2018 Gong G, Wang H, Kong X, Duan R, Dong TTX, Tsim KWK. Flavonoids are identified from the extract of Scutellariae Radix to suppress inflammatory-induced angiogenic responses in cultured RAW 264.7 macrophages. Scientific Reports. 8: 17412. PMID 30479366 DOI: 10.1038/s41598-018-35817-2  0.56
2018 Wong ZCF, Chan GKL, Wu KQY, Poon KKM, Chen Y, Dong TTX, Tsim KWK. Complete digestion of edible bird's nest releases free N-acetylneuraminic acid and small peptides: an efficient method to improve functional properties. Food & Function. PMID 30206602 DOI: 10.1039/c8fo00991k  0.56
2018 Zhou LP, Wong KY, Yeung HT, Dong XL, Xiao HH, Gong AG, Tsim KW, Wong MS. Bone Protective Effects of Danggui Buxue Tang Alone and in Combination With Tamoxifen or Raloxifene and . Frontiers in Pharmacology. 9: 779. PMID 30150931 DOI: 10.3389/fphar.2018.00779  0.48
2018 Lou JS, Xia YT, Wang HY, Kong XP, Yao P, Dong TTX, Zhou ZY, Tsim KWK. The WT1/MVP-Mediated Stabilization on mTOR/AKT Axis Enhances the Effects of Cisplatin in Non-small Cell Lung Cancer by a Reformulated Yu Ping Feng San Herbal Preparation. Frontiers in Pharmacology. 9: 853. PMID 30131696 DOI: 10.3389/fphar.2018.00853  0.56
2018 Zheng Y, Wang H, Yang M, Peng G, Dong TTX, Xu ML, Tsim KWK. Prenylated Flavonoids from Roots of Glycyrrhiza uralensis Induce Differentiation of B16-F10 Melanoma Cells. International Journal of Molecular Sciences. 19. PMID 30115883 DOI: 10.3390/ijms19082422  0.56
2018 Wu Q, Fung AHY, Xu ML, Poon K, Liu EYL, Kong XP, Yao P, Xiong QP, Dong TTX, Tsim KWK. Microphthalmia-associated transcription factor up-regulates acetylcholinesterase expression during melanogenesis of murine melanoma cells. The Journal of Biological Chemistry. PMID 30076217 DOI: 10.1074/jbc.RA118.003729  0.56
2018 Hu WH, Wang HY, Kong XP, Xiong QP, Poon KK, Xu L, Duan R, Chan GK, Dong TT, Tsim KW. Polydatin suppresses VEGF-induced angiogenesis through binding with VEGF and inhibiting its receptor signaling. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201800750R. PMID 29989844 DOI: 10.1096/fj.201800750R  0.48
2018 Xu YC, Tao Z, Jin Y, Yuan Y, Dong TTX, Tsim KWK, Zhou ZY. Flavonoids, a Potential New Insight of Leucaena leucocephala Foliage in Ruminant Health. Journal of Agricultural and Food Chemistry. PMID 29953227 DOI: 10.1021/acs.jafc.8b02739  0.56
2018 Gong AGW, Duan R, Wang HY, Kong XP, Dong TTX, Tsim KWK, Chan K. Evaluation of the Pharmaceutical Properties and Value of Astragali Radix. Medicines (Basel, Switzerland). 5. PMID 29883402 DOI: 10.3390/medicines5020046  0.56
2018 Li Z, Lam KYC, Liu X, Qi A, Yao P, Dong TTX, Yi T, Tsim KWK, Chen J. A Chinese Herbal Preparation, Xiao-Er-An-Shen Decoction, Exerts Neuron Protection by Modulation of Differentiation and Antioxidant Activity in Cultured PC12 Cells. Evidence-Based Complementary and Alternative Medicine : Ecam. 2018: 8670421. PMID 29853977 DOI: 10.1155/2018/8670421  0.56
2018 Huang Y, Kwan KKL, Leung KW, Wang H, Kong XP, Dong TTX, Tsim KWK. The Extracts and Major Compounds Derived from Astragali Radix Alter Mitochondrial Bioenergetics in Cultured Cardiomyocytes: Comparison of Various Polar Solvents and Compounds. International Journal of Molecular Sciences. 19. PMID 29799462 DOI: 10.3390/ijms19061574  0.56
2018 Wong ZCF, Chan GKL, Dong TTX, Tsim KWK. Binding of Fe ion to acidic mammalian chitinase-like protein directs the origin of red color in edible bird's nest. Journal of Agricultural and Food Chemistry. PMID 29751728 DOI: 10.1021/acs.jafc.8b01500  0.56
2018 Xie HQ, Xia Y, Xu T, Chen Y, Fu H, Li Y, Luo Y, Xu L, Tsim KWK, Zhao B. 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces alterations in myogenic differentiation of C2C12 cells. Environmental Pollution (Barking, Essex : 1987). 235: 965-973. PMID 29751400 DOI: 10.1016/j.envpol.2017.12.016  0.56
2018 Chan GKL, Hu WWH, Zheng ZX, Huang M, Lin YXY, Wang CY, Gong AGW, Yang XY, Tsim KWK, Dong TTX. Quercetin Potentiates the NGF-Induced Effects in Cultured PC 12 Cells: Identification by HerboChips Showing a Binding with NGF. Evidence-Based Complementary and Alternative Medicine : Ecam. 2018: 1502457. PMID 29681968 DOI: 10.1155/2018/1502457  0.56
2018 Xu ML, Luk WKW, Bi CWC, Liu EYL, Wu KQY, Yao P, Dong TTX, Tsim KWK. Erythropoietin regulates the expression of dimeric form of acetylcholinesterase during differentiation of erythroblast. Journal of Neurochemistry. PMID 29675901 DOI: 10.1111/jnc.14448  0.56
2018 Hu WH, Chan GK, Lou JS, Wu QY, Wang HY, Duan R, Cheng MY, Dong TT, Tsim KW. The extract of Polygoni Cuspidati Rhizoma et Radix suppresses the vascular endothelial growth factor-induced angiogenesis. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. 42: 135-143. PMID 29655679 DOI: 10.1016/j.phymed.2018.03.029  0.48
2018 Chen J, Gong AGW, Liu X, Li Z, Qi A, Dong TTX, Yi T, Tsim KWK, Li S. A Chinese herbal decoction, Jian-Pi-Yi-Shen, regulates the expressions of erythropoietin and pro-inflammatory cytokines in cultured cells. Bmc Complementary and Alternative Medicine. 18: 119. PMID 29615029 DOI: 10.1186/s12906-018-2146-4  0.56
2018 Liu EYL, Xu ML, Jin Y, Wu Q, Dong TTX, Tsim KWK. Genistein, a Phytoestrogen in Soybean, Induces the Expression of Acetylcholinesterase via G Protein-Coupled Receptor 30 in PC12 Cells. Frontiers in Molecular Neuroscience. 11: 59. PMID 29535608 DOI: 10.3389/fnmol.2018.00059  0.56
2018 Gong AGW, Duan R, Wang HY, Dong TTX, Tsim KWK. Calycosin Orchestrates Osteogenesis of Danggui Buxue Tang in Cultured Osteoblasts: Evaluating the Mechanism of Action by Omics and Chemical Knock-out Methodologies. Frontiers in Pharmacology. 9: 36. PMID 29449812 DOI: 10.3389/fphar.2018.00036  0.56
2018 Xu Y, Tao Z, Jin Y, Chen S, Zhou Z, Gong AGW, Yuan Y, Dong TTX, Tsim KWK. Jasmonate-Elicited Stress Induces Metabolic Change in the Leaves of Leucaena leucocephala. Molecules (Basel, Switzerland). 23. PMID 29364191 DOI: 10.3390/molecules23020188  0.56
2018 Tao HX, Xiong W, Zhao GD, Peng Y, Zhong ZF, Xu L, Duan R, Tsim KWK, Yu H, Wang YT. Discrimination of three Siegesbeckiae Herba species using UPLC-QTOF/MS-based metabolomics approach. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. PMID 29305931 DOI: 10.1016/j.fct.2017.12.068  0.48
2017 Yan L, Wei M, Gong AG, Song P, Lou J, Bi CW, Xu SL, Xiong A, Dong TT, Tsim KW. A Modified Chinese Herbal Decoction (Kai-Xin-San) Promotes NGF-Induced Neuronal Differentiation in PC12 Cells via Up-Regulating Trk A Signaling. Frontiers in Cell and Developmental Biology. 5: 118. PMID 29312939 DOI: 10.3389/fcell.2017.00118  0.48
2017 Wing Leung K, Wong ZCF, Ho JYM, Yip AWS, Cheung JKH, Ho KKL, Duan R, Tsim KWK. Surveillance of drug abuse in Hong Kong by hair analysis using LC-MS/MS. Drug Testing and Analysis. PMID 29205946 DOI: 10.1002/dta.2345  0.48
2017 Lou JS, Bi WC, Chan GKL, Jin Y, Wong CW, Zhou ZY, Wang HY, Yao P, Dong TTX, Tsim KWK. Ginkgetin induces autophagic cell death through p62/SQSTM1-mediated autolysosome formation and redox setting in non-small cell lung cancer. Oncotarget. 8: 93131-93148. PMID 29190983 DOI: 10.18632/oncotarget.21862  0.56
2017 Gong AGW, Wang HY, Dong TTX, Tsim KWK, Zheng YZ. Danggui Buxue Tang, a simple Chinese formula containing Astragali Radix and Angelicae Sinensis Radix, stimulates the expressions of neurotrophic factors in cultured SH-SY5Y cells. Chinese Medicine. 12: 24. PMID 28852418 DOI: 10.1186/s13020-017-0144-y  0.56
2017 Lam KYC, Huang Y, Yao P, Wang H, Dong TTX, Zhou Z, Tsim KWK. Comparative Study of Different Acorus Species in Potentiating Neuronal Differentiation in Cultured PC12 Cells. Phytotherapy Research : Ptr. PMID 28833752 DOI: 10.1002/ptr.5904  0.56
2017 Ye Z, Dai JR, Zhang CG, Lu Y, Wu LL, Gong AGW, Xu H, Tsim KWK, Wang ZT. Chemical Differentiation of Dendrobium officinale and Dendrobium devonianum by Using HPLC Fingerprints, HPLC-ESI-MS, and HPTLC Analyses. Evidence-Based Complementary and Alternative Medicine : Ecam. 2017: 8647212. PMID 28769988 DOI: 10.1155/2017/8647212  0.44
2017 Chen J, Liu X, Li Z, Qi A, Yao P, Zhou Z, Dong TTX, Tsim KWK. A Review of Dietary Ziziphus jujuba Fruit (Jujube): Developing Health Food Supplements for Brain Protection. Evidence-Based Complementary and Alternative Medicine : Ecam. 2017: 3019568. PMID 28680447 DOI: 10.1155/2017/3019568  0.56
2017 Xu ML, Bi CWC, Liu EYL, Dong TTX, Tsim KWK. Wnt3a Induces the Expression of Acetylcholinesterase during Osteoblast Differentiation via the Runx2 Transcription Factor. The Journal of Biological Chemistry. PMID 28607150 DOI: 10.1074/jbc.M117.777581  0.56
2017 Lam KYC, Yao P, Wang H, Duan R, Dong TTX, Tsim KWK. Asarone from Acori Tatarinowii Rhizome prevents oxidative stress-induced cell injury in cultured astrocytes: A signaling triggered by Akt activation. Plos One. 12: e0179077. PMID 28598994 DOI: 10.1371/journal.pone.0179077  0.56
2017 Zhu Y, Chao C, Duan X, Cheng X, Liu P, Su S, Duan J, Dong TT, Tsim KW. Kai-Xin-San series formulae alleviate depressive-like behaviors on chronic mild stressed mice via regulating neurotrophic factor system on hippocampus. Scientific Reports. 7: 1467. PMID 28469194 DOI: 10.1038/s41598-017-01561-2  0.48
2017 Zhang L, Gong AG, Riaz K, Deng JY, Ho CM, Lin HQ, Dong TT, Lee YK, Tsim KW. A novel combination of four flavonoids derived from Astragali Radix relieves the symptoms of cyclophosphamide-induced anemic rats. Febs Open Bio. 7: 318-323. PMID 28286727 DOI: 10.1002/2211-5463.12146  0.48
2017 Lin HQ, Gong AG, Wang HY, Duan R, Dong TT, Zhao KJ, Tsim KW. Danggui Buxue Tang (Astragali Radix and Angelicae Sinensis Radix) for Menopausal Symptoms: A Review. Journal of Ethnopharmacology. PMID 28163116 DOI: 10.1016/j.jep.2017.01.044  0.48
2016 Gong AG, Huang VY, Wang HY, Lin HQ, Dong TT, Tsim KW. Ferulic Acid Orchestrates Anti-Oxidative Properties of Danggui Buxue Tang, an Ancient Herbal Decoction: Elucidation by Chemical Knock-Out Approach. Plos One. 11: e0165486. PMID 27824860 DOI: 10.1371/journal.pone.0165486  0.48
2016 Gong AG, Zhang LM, Lam CT, Xu ML, Wang HY, Lin HQ, Dong TT, Tsim KW. Polysaccharide of Danggui Buxue Tang, an Ancient Chinese Herbal Decoction, Induces Expression of Pro-inflammatory Cytokines Possibly Via Activation of NFκB Signaling in Cultured RAW 264.7 Cells. Phytotherapy Research : Ptr. PMID 27807897 DOI: 10.1002/ptr.5745  0.48
2016 Lam KY, Ku CF, Wang HY, Chan GK, Yao P, Lin HQ, Dong TT, Zhang HJ, Tsim KW. Authentication of Acori Tatarinowii Rhizoma (Shi Chang Pu) and its adulterants by morphological distinction, chemical composition and ITS sequencing. Chinese Medicine. 11: 41. PMID 27708691 DOI: 10.1186/s13020-016-0113-x  0.36
2016 Lam KY, Chen J, Lam CT, Wu Q, Yao P, Dong TT, Lin H, Tsim KW. Asarone from Acori Tatarinowii Rhizoma Potentiates the Nerve Growth Factor-Induced Neuronal Differentiation in Cultured PC12 Cells: A Signaling Mediated by Protein Kinase A. Plos One. 11: e0163337. PMID 27685847 DOI: 10.1371/journal.pone.0163337  0.36
2016 Zhu Y, Duan X, Cheng X, Cheng X, Li X, Zhang L, Liu P, Shulan S, Duan JA, Dong TT, Tsim KW, Huang F. Kai-Xin-San, a standardized traditional Chinese medicine formula, up-regulates the expressions of synaptic proteins on hippocampus of chronic mild stress induced depressive rats and primary cultured rat hippocampal neuron. Journal of Ethnopharmacology. PMID 27660009 DOI: 10.1016/j.jep.2016.09.037  0.36
2016 Lou JS, Yan L, Bi CW, Chan GK, Wu QY, Liu YL, Huang Y, Yao P, Du CY, Dong TT, Tsim KW. Yu Ping Feng San reverses cisplatin-induced multi-drug resistance in lung cancer cells via regulating drug transporters and p62/TRAF6 signalling. Scientific Reports. 6: 31926. PMID 27558312 DOI: 10.1038/srep31926  0.36
2016 Zhu Y, Duan X, Huang F, Cheng X, Zhang L, Liu P, Shulan S, Duan JA, Dong TT, Tsim KW. Kai-Xin-San, a traditional Chinese medicine formula, induces neuronal differentiation of cultured PC12 Cells: modulating neurotransmitter regulation enzymes and potentiating NGF inducing neurite outgrowth. Journal of Ethnopharmacology. PMID 27530376 DOI: 10.1016/j.jep.2016.08.013  0.36
2016 Xu L, Chen Y, Xie HQ, Xu T, Fu H, Zhang S, Tsim KW, Bi CW, Zhao B. 2,3,7,8-Tetrachlorodibenzo-p-dioxin suppress AChE activity in NGF treated PC12 cells. Chemico-Biological Interactions. PMID 27502150 DOI: 10.1016/j.cbi.2016.08.003  0.36
2016 Lee PS, Zhang LM, Yan AL, Lam KY, Dong TT, Lin H, Chan GK, Tsim KW. Indication of nerve growth factor binding components from herbal extracts by HerboChip: a platform for drug screening on a chip. Chinese Medicine. 11: 34. PMID 27453720 DOI: 10.1186/s13020-016-0107-8  0.48
2016 Xu D, Chen H, Mak S, Hu S, Tsim KW, Hu Y, Sun Y, Zhang G, Wang Y, Zhang Z, Han Y. Neuroprotection against glutamate-induced excitotoxicity and induction of neurite outgrowth by T-006, a novel multifunctional derivative of tetramethylpyrazine in neuronal cell models. Neurochemistry International. PMID 27445088 DOI: 10.1016/j.neuint.2016.07.006  0.36
2016 Yan L, Hu Q, Mak MS, Lou J, Xu SL, Bi CW, Zhu Y, Wang H, Dong TT, Tsim KW. A Chinese herbal decoction, reformulated from Kai-Xin-San, relieves the depression-like symptoms in stressed rats and induces neurogenesis in cultured neurons. Scientific Reports. 6: 30014. PMID 27444820 DOI: 10.1038/srep30014  0.36
2016 Xiong A, Yan AL, Bi CW, Lam KY, Chan GK, Lau KK, Dong TT, Lin H, Yang L, Wang Z, Tsim KW. Clivorine, an otonecine pyrrolizidine alkaloid from Ligularia species, impairs neuronal differentiation via NGF-induced signaling pathway in cultured PC12 cells. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. 23: 931-8. PMID 27387401 DOI: 10.1016/j.phymed.2016.06.006  0.36
2016 Cui JD, Xu ML, Liu EY, Dong TT, Lin HQ, Tsim KW, Bi CW. Expression of globular form acetylcholinesterase is not altered in P2Y1R knock-out mouse brain. Chemico-Biological Interactions. PMID 27378627 DOI: 10.1016/j.cbi.2016.06.028  0.48
2016 Xie HQ, Xu T, Chen Y, Li Y, Xia Y, Xu SL, Wang L, Tsim KW, Zhao B. New perspectives for multi-level regulations of neuronal acetylcholinesterase by dioxins. Chemico-Biological Interactions. PMID 27374124 DOI: 10.1016/j.cbi.2016.06.030  0.56
2016 Gong AG, Lau KM, Xu ML, Lin HQ, Dong TT, Zheng KY, Zhao KJ, Tsim KW. The estrogenic properties of Danggui Buxue Tang, a Chinese herbal decoction, are triggered predominantly by calycosin in MCF-7 cells. Journal of Ethnopharmacology. PMID 27196297 DOI: 10.1016/j.jep.2016.05.035  0.36
2016 Lam CT, Gong AG, Lam KY, Zhang LM, Chen JP, Dong TT, Lin HQ, Tsim KW. Jujube-Containing Herbal Decoctions Induce Neuronal Differentiation and the Expression of Anti-oxidant Enzymes in Cultured PC12 cells. Journal of Ethnopharmacology. PMID 27178633 DOI: 10.1016/j.jep.2016.05.015  0.36
2016 Lau KM, Gong AG, Xu ML, Lam CT, Zhang LM, Bi CW, Cui D, Cheng AW, Dong TT, Tsim KW, Lin H. Transcriptional activity of acetylcholinesterase gene is regulated by DNA methylation during C2C12 myogenesis. Brain Research. PMID 27021952 DOI: 10.1016/j.brainres.2016.03.013  0.36
2016 Xu ML, Bi CW, Kong AY, Dong TT, Wong YH, Tsim KW. Flavonoids induce the expression of acetylcholinesterase in cultured osteoblasts. Chemico-Biological Interactions. PMID 27019979 DOI: 10.1016/j.cbi.2016.03.025  0.36
2016 Gong AG, Lau KM, Zhang LM, Lin HQ, Dong TT, Tsim KW. Danggui Buxue Tang, Chinese Herbal Decoction Containing Astragali Radix and Angelicae Sinensis Radix, Induces Production of Nitric Oxide in Endothelial Cells: Signaling Mediated by Phosphorylation of Endothelial Nitric Oxide Synthase. Planta Medica. PMID 26824621 DOI: 10.1055/s-0035-1558332  0.36
2015 Leung KW, Wong ZC, Ho JY, Yip AW, Ng JS, Ip SP, Ng WY, Ho KK, Duan R, Zhu KY, Tsim KW. Determination of hair ketamine cut-off value from Hong Kong ketamine users by LC-MS/MS analysis. Forensic Science International. 259: 53-58. PMID 26750989 DOI: 10.1016/j.forsciint.2015.12.004  0.36
2015 Lam KY, Chan GK, Xin GZ, Xu H, Ku CF, Chen JP, Yao P, Lin HQ, Dong TT, Tsim KW. Authentication of Cordyceps sinensis by DNA Analyses: Comparison of ITS Sequence Analysis and RAPD-Derived Molecular Markers. Molecules (Basel, Switzerland). 20: 22454-62. PMID 26694332 DOI: 10.3390/molecules201219861  0.36
2015 Zong SY, Han H, Wang B, Li N, Dong TT, Zhang T, Tsim KW. Fast Simultaneous Determination of 13 Nucleosides and Nucleobases in Cordyceps sinensis by UHPLC-ESI-MS/MS. Molecules (Basel, Switzerland). 20: 21816-25. PMID 26690105 DOI: 10.3390/molecules201219807  0.36
2015 Chen J, Lam CT, Li Z, Yao P, Lin H, Dong TT, Tsim KW. Extract of Ziziphus jujuba Fruit (Jujube) Stimulates Expression of Enzymes Responsible for Heme Recycle via Anti-oxidant Response Element in Cultured Murine Macrophages. Phytotherapy Research : Ptr. PMID 26646685 DOI: 10.1002/ptr.5526  0.36
2015 Miernisha A, Bi CW, Cheng LK, Xing JG, Liu J, Maiwulanjiang M, Aisa HA, Dong TT, Lin H, Huang Y, Tsim KW. Badiranji Buya Keli, a Traditional Uyghur Medicine, Induces Vasodilation in Rat Artery: Signaling Mediated by Nitric Oxide Production in Endothelial Cells. Phytotherapy Research : Ptr. PMID 26486882 DOI: 10.1002/ptr.5494  0.36
2015 Lam CT, Chan PH, Lee PS, Lau KM, Kong AY, Gong AG, Xu ML, Lam KY, Dong TT, Lin H, Tsim KW. Chemical and biological assessment of Jujube (Ziziphus jujuba)-containing herbal decoctions: Induction of erythropoietin expression in cultures. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. PMID 26432380 DOI: 10.1016/j.jchromb.2015.09.021  0.36
2015 Xu ML, Luk WK, Lau KM, Bi CW, Cheng AW, Gong AG, Lin H, Tsim KW. Three N-Glycosylation Sites of Human Acetylcholinesterase Shares Similar Glycan Composition. Journal of Molecular Neuroscience : Mn. PMID 26231935 DOI: 10.1007/s12031-015-0629-z  0.36
2015 Xu ML, Bi CW, Cheng LK, Mak S, Yao P, Luk WK, Lau KK, Cheng AW, Tsim KW. Reduced Expression of P2Y2 Receptor and Acetylcholinesterase at Neuromuscular Junction of P2Y1 Receptor Knock-out Mice. Journal of Molecular Neuroscience : Mn. PMID 26036470 DOI: 10.1007/s12031-015-0591-9  0.36
2015 Chen HY, Xu DP, Tan GL, Cai W, Zhang GX, Cui W, Wang JZ, Long C, Sun YW, Yu P, Tsim KW, Zhang ZJ, Han YF, Wang YQ. A Potent Multi-functional Neuroprotective Derivative of Tetramethylpyrazine. Journal of Molecular Neuroscience : Mn. PMID 25982925 DOI: 10.1007/s12031-015-0566-x  0.36
2015 Hu SQ, Cui W, Mak SH, Choi CL, Hu YJ, Li G, Tsim KW, Pang YP, Han YF. Robust Neuritogenesis-Promoting Activity by Bis(heptyl)-Cognitin Through the Activation of alpha7-Nicotinic Acetylcholine Receptor/ERK Pathway. Cns Neuroscience & Therapeutics. 21: 520-9. PMID 25917415 DOI: 10.1111/cns.12401  0.36
2015 Gong AG, Li N, Lau KM, Lee PS, Yan L, Xu ML, Lam CT, Kong AY, Lin HQ, Dong TT, Tsim KW. Calycosin orchestrates the functions of Danggui Buxue Tang, a Chinese herbal decoction composing of Astragali Radix and Angelica Sinensis Radix: An evaluation by using calycosin-knock out herbal extract. Journal of Ethnopharmacology. 168: 150-157. PMID 25796405 DOI: 10.1016/j.jep.2015.03.033  0.36
2015 Maiwulanjiang M, Bi CW, Lee PS, Xin G, Miernisha A, Lau KM, Xiong A, Li N, Dong TT, Aisa HA, Tsim KW. The volatile oil of Nardostachyos Radix et Rhizoma induces endothelial nitric oxide synthase activity in HUVEC cells. Plos One. 10: e0116761. PMID 25643147 DOI: 10.1371/journal.pone.0116761  0.36
2015 Du CY, Zheng KY, Bi CW, Dong TT, Lin H, Tsim KW. Yu Ping Feng San, an Ancient Chinese Herbal Decoction, Induces Gene Expression of Anti-viral Proteins and Inhibits Neuraminidase Activity. Phytotherapy Research : Ptr. 29: 656-61. PMID 25586308 DOI: 10.1002/ptr.5290  0.36
2015 Yan L, Xu SL, Zhu KY, Lam KY, Xin G, Maiwulanjiang M, Li N, Dong TT, Lin H, Tsim KW. Optimizing the compatibility of paired-herb in an ancient Chinese herbal decoction Kai-Xin-San in activating neurofilament expression in cultured PC12 cells. Journal of Ethnopharmacology. 162: 155-62. PMID 25560671 DOI: 10.1016/j.jep.2014.12.049  0.36
2015 Chen J, Chan PH, Lam CT, Li Z, Lam KY, Yao P, Dong TT, Lin H, Lam H, Tsim KW. Fruit of Ziziphus jujuba (Jujube) at two stages of maturity: distinction by metabolic profiling and biological assessment. Journal of Agricultural and Food Chemistry. 63: 739-44. PMID 25544316 DOI: 10.1021/jf5041564  0.36
2015 Hu S, Wang R, Cui W, Zhang Z, Mak S, Xu D, Choi C, Tsim KW, Carlier PR, Lee M, Han Y. Inhibiting β-amyloid-associated Alzheimer's pathogenesis in vitro and in vivo by a multifunctional dimeric bis(12)-hupyridone derived from its natural analogue. Journal of Molecular Neuroscience : Mn. 55: 1014-21. PMID 25407821 DOI: 10.1007/s12031-014-0458-5  0.36
2015 Jiao Y, Chen PH, Xiong AZ, Wang ZT, Tsim KW, Chou GX, Xu H. Evaluation of hemostatic and anti-inflammatory activities of extracts from different Lagochilus species in experimental animals: comparison of different extractives and sources. Phytotherapy Research : Ptr. 29: 22-9. PMID 25175534 DOI: 10.1002/ptr.5216  0.36
2014 Xiong A, Fang L, Yang X, Yang F, Qi M, Kang H, Yang L, Tsim KW, Wang Z. An application of target profiling analyses in the hepatotoxicity assessment of herbal medicines: comparative characteristic fingerprint and bile acid profiling of Senecio vulgaris L. and Senecio scandens Buch.-Ham. Analytical and Bioanalytical Chemistry. 406: 7715-27. PMID 25234307 DOI: 10.1007/s00216-014-8175-z  0.36
2014 Zierau O, Zheng KY, Papke A, Dong TT, Tsim KW, Vollmer G. Functions of Danggui Buxue Tang, a Chinese Herbal Decoction Containing Astragali Radix and Angelicae Sinensis Radix, in Uterus and Liver are Both Estrogen Receptor-Dependent and -Independent. Evidence-Based Complementary and Alternative Medicine : Ecam. 2014: 438531. PMID 25214874 DOI: 10.1155/2014/438531  0.36
2014 Chen J, Lam CT, Kong AY, Zhang WL, Zhan JY, Bi CW, Chan GK, Lam KY, Yao P, Dong TT, Tsim KW. The extract of Ziziphus jujuba fruit (jujube) induces expression of erythropoietin via hypoxia-inducible factor-1α in cultured Hep3B cells. Planta Medica. 80: 1622-7. PMID 25184890 DOI: 10.1055/s-0034-1383049  0.36
2014 Zhan JY, Yao P, Bi CW, Zheng KY, Zhang WL, Chen JP, Dong TT, Su ZR, Tsim KW. The sulfur-fumigation reduces chemical composition and biological properties of Angelicae Sinensis Radix. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. 21: 1318-24. PMID 25172796 DOI: 10.1016/j.phymed.2014.07.002  0.36
2014 Chen J, Yan AL, Lam KY, Lam CT, Li N, Yao P, Xiong A, Dong TT, Tsim KW. A chemically standardized extract of Ziziphus jujuba fruit (Jujube) stimulates expressions of neurotrophic factors and anti-oxidant enzymes in cultured astrocytes. Phytotherapy Research : Ptr. 28: 1727-30. PMID 25066116 DOI: 10.1002/ptr.5202  0.36
2014 Du CY, Choi RC, Dong TT, Lau DT, Tsim KW. Yu Ping Feng San, an ancient Chinese herbal decoction, regulates the expression of inducible nitric oxide synthase and cyclooxygenase-2 and the activity of intestinal alkaline phosphatase in cultures. Plos One. 9: e100382. PMID 24967898 DOI: 10.1371/journal.pone.0100382  0.36
2014 Zhan JY, Zheng KY, Zhang WL, Chen JP, Yao P, Bi CW, Dong TT, Tsim KW. Identification of Angelica oil as a suppressor for the biological properties of Danggui Buxue tang: a Chinese herbal decoction composes of Astragali Radix and Angelica Sinensis Radix. Journal of Ethnopharmacology. 154: 825-31. PMID 24837305 DOI: 10.1016/j.jep.2014.05.007  0.36
2014 Chan PH, Zhang WL, Cheung CY, Tsim KW, Lam H. Quality Control of Danggui Buxue Tang, a Traditional Chinese Medicine Decoction, by (1)H-NMR Metabolic Profiling. Evidence-Based Complementary and Alternative Medicine : Ecam. 2014: 567893. PMID 24826194 DOI: 10.1155/2014/567893  0.36
2014 Chen J, Du CY, Lam KY, Zhang WL, Lam CT, Yan AL, Yao P, Lau DT, Dong TT, Tsim KW. The standardized extract of Ziziphus jujuba fruit (jujube) regulates pro-inflammatory cytokine expression in cultured murine macrophages: suppression of lipopolysaccharide-stimulated NF-κB activity. Phytotherapy Research : Ptr. 28: 1527-32. PMID 24806434 DOI: 10.1002/ptr.5160  0.36
2014 Mak S, Luk WW, Cui W, Hu S, Tsim KW, Han Y. Synergistic inhibition on acetylcholinesterase by the combination of berberine and palmatine originally isolated from Chinese medicinal herbs. Journal of Molecular Neuroscience : Mn. 53: 511-6. PMID 24793543 DOI: 10.1007/s12031-014-0288-5  0.36
2014 Xin GZ, Hu B, Shi ZQ, Lam YC, Dong TT, Li P, Yao ZP, Tsim KW. Rapid identification of plant materials by wooden-tip electrospray ionization mass spectrometry and a strategy to differentiate the bulbs of Fritillaria. Analytica Chimica Acta. 820: 84-91. PMID 24745741 DOI: 10.1016/j.aca.2014.02.039  0.36
2014 Zhang WL, Chen JP, Lam KY, Zhan JY, Yao P, Dong TT, Tsim KW. Hydrolysis of Glycosidic Flavonoids during the Preparation of Danggui Buxue Tang: An Outcome of Moderate Boiling of Chinese Herbal Mixture. Evidence-Based Complementary and Alternative Medicine : Ecam. 2014: 608721. PMID 24744813 DOI: 10.1155/2014/608721  0.36
2014 Chan PH, Zhang WL, Lau CH, Cheung CY, Keun HC, Tsim KW, Lam H. Metabonomic analysis of water extracts from different angelica roots by ¹H-nuclear magnetic resonance spectroscopy. Molecules (Basel, Switzerland). 19: 3460-70. PMID 24658570 DOI: 10.3390/molecules19033460  0.36
2014 Xin GZ, Lam YC, Maiwulanjiang M, Chan GK, Zhu KY, Tang WL, Dong TT, Shi ZQ, Li P, Tsim KW. Authentication of Bulbus Fritillariae Cirrhosae by RAPD-derived DNA markers. Molecules (Basel, Switzerland). 19: 3450-9. PMID 24658569 DOI: 10.3390/molecules19033450  0.36
2014 Xiong A, Yang F, Fang L, Yang L, He Y, Wan YJ, Wan YY, Xu Y, Qi M, Wang X, Yu K, Tsim KW, Wang Z. Metabolomic and genomic evidence for compromised bile acid homeostasis by senecionine, a hepatotoxic pyrrolizidine alkaloid. Chemical Research in Toxicology. 27: 775-86. PMID 24641316 DOI: 10.1021/tx400451q  0.36
2014 Maiwulanjiang M, Chen J, Xin G, Gong AG, Miernisha A, Du CY, Lau KM, Lee PS, Chen J, Dong TT, Aisa HA, Tsim KW. The volatile oil of Nardostachyos Radix et Rhizoma inhibits the oxidative stress-induced cell injury via reactive oxygen species scavenging and Akt activation in H9c2 cardiomyocyte. Journal of Ethnopharmacology. 153: 491-8. PMID 24632018 DOI: 10.1016/j.jep.2014.03.010  0.36
2014 García-Ayllón MS, Campanari ML, Montenegro MF, Cuchillo-Ibáñez I, Belbin O, Lleó A, Tsim K, Vidal CJ, Sáez-Valero J. Presenilin-1 influences processing of the acetylcholinesterase membrane anchor PRiMA. Neurobiology of Aging. 35: 1526-36. PMID 24612677 DOI: 10.1016/j.neurobiolaging.2014.01.147  0.36
2014 Ip PS, Tsim KW, Chan K, Bauer R. Application of complementary and alternative medicine on neurodegenerative disorders 2013. Evidence-Based Complementary and Alternative Medicine : Ecam. 2014: 463929. PMID 24587808 DOI: 10.1155/2014/463929  0.36
2014 Chen J, Maiwulanjiang M, Lam KY, Zhang WL, Zhan JY, Lam CT, Xu SL, Zhu KY, Yao P, Lau DT, Dong TT, Tsim KW. A standardized extract of the fruit of Ziziphus jujuba (Jujube) induces neuronal differentiation of cultured PC12 cells: a signaling mediated by protein kinase A. Journal of Agricultural and Food Chemistry. 62: 1890-7. PMID 24520858 DOI: 10.1021/jf405093f  0.36
2014 Zheng KY, Zhang ZX, Du CY, Zhang WL, Bi CW, Choi RC, Dong TT, Tsim KW. Ferulic acid enhances the chemical and biological properties of astragali radix: a stimulator for danggui buxue tang, an ancient Chinese herbal decoction. Planta Medica. 80: 159-64. PMID 24488720 DOI: 10.1055/s-0033-1360314  0.36
2014 Bi CW, Luk WK, Campanari ML, Liu YH, Xu L, Lau KM, Xu ML, Choi RC, Sáez-Valero J, Tsim KW. Quantification of the transcripts encoding different forms of AChE in various cell types: real-time PCR coupled with standards in revealing the copy number. Journal of Molecular Neuroscience : Mn. 53: 461-8. PMID 24385197 DOI: 10.1007/s12031-013-0210-6  0.36
2014 Campanari ML, García-Ayllón MS, Blazquez-Llorca L, Luk WK, Tsim K, Sáez-Valero J. Acetylcholinesterase protein level is preserved in the Alzheimer's brain. Journal of Molecular Neuroscience : Mn. 53: 446-53. PMID 24318838 DOI: 10.1007/s12031-013-0183-5  0.36
2014 Zou XH, Xie HQ, Zha GC, Chen VP, Sun YJ, Zheng YZ, Tsim KW, Dong TT, Choi RC, Luk WK. Characterizations of cholinesterases in golden apple snail (Pomacea canaliculata). Journal of Molecular Neuroscience : Mn. 53: 424-8. PMID 24217797 DOI: 10.1007/s12031-013-0168-4  0.36
2013 Su JY, Xie QF, Liu WJ, Lai P, Liu DD, Tang LH, Dong TT, Su ZR, Tsim KW, Lai XP, Li KY. Perimenopause Amelioration of a TCM Recipe Composed of Radix Astragali, Radix Angelicae Sinensis, and Folium Epimedii: An In Vivo Study on Natural Aging Rat Model. Evidence-Based Complementary and Alternative Medicine : Ecam. 2013: 747240. PMID 24454513 DOI: 10.1155/2013/747240  0.36
2013 Chen J, Li Z, Zheng KY, Guo AJ, Zhu KY, Zhang WL, Zhan JY, Dong TT, Su Z, Tsim KW. Chemical fingerprinting and quantitative analysis of two common Gleditsia sinensis fruits using HPLC-DAD. Acta Pharmaceutica (Zagreb, Croatia). 63: 505-15. PMID 24451075 DOI: 10.2478/acph-2013-0036  0.36
2013 Xu SL, Zhu KY, Bi CW, Yan L, Men SW, Dong TT, Tsim KW. Flavonoids, derived from traditional Chinese medicines, show roles in the differentiation of neurons: possible targets in developing health food products. Birth Defects Research. Part C, Embryo Today : Reviews. 99: 292-9. PMID 24339039 DOI: 10.1002/bdrc.21054  0.36
2013 Du CY, Choi RC, Zheng KY, Dong TT, Lau DT, Tsim KW. Yu Ping Feng San, an ancient Chinese herbal decoction containing Astragali Radix, Atractylodis Macrocephalae Rhizoma and Saposhnikoviae Radix, regulates the release of cytokines in murine macrophages. Plos One. 8: e78622. PMID 24244327 DOI: 10.1371/journal.pone.0078622  0.36
2013 Xu SL, Zhu KY, Bi CW, Choi RC, Miernisha A, Yan AL, Maiwulanjiang M, Men SW, Dong TT, Tsim KW. Flavonoids induce the expression of synaptic proteins, synaptotagmin, and postsynaptic density protein-95 in cultured rat cortical neuron. Planta Medica. 79: 1710-4. PMID 24243544 DOI: 10.1055/s-0033-1351023  0.36
2013 Zhu KY, Xu SL, Choi RC, Yan AL, Dong TT, Tsim KW. Kai-xin-san, a chinese herbal decoction containing ginseng radix et rhizoma, polygalae radix, acori tatarinowii rhizoma, and poria, stimulates the expression and secretion of neurotrophic factors in cultured astrocytes. Evidence-Based Complementary and Alternative Medicine : Ecam. 2013: 731385. PMID 24222781 DOI: 10.1155/2013/731385  0.36
2013 Maiwulanjiang M, Zhu KY, Chen J, Miernisha A, Xu SL, Du CY, Lau KK, Choi RC, Dong TT, Aisa HA, Tsim KW. Song bu li decoction, a traditional uyghur medicine, protects cell death by regulation of oxidative stress and differentiation in cultured PC12 cells. Evidence-Based Complementary and Alternative Medicine : Ecam. 2013: 687958. PMID 24198845 DOI: 10.1155/2013/687958  0.36
2013 Choi RC, Zhu JT, Yung AW, Lee PS, Xu SL, Guo AJ, Zhu KY, Dong TT, Tsim KW. Synergistic Action of Flavonoids, Baicalein, and Daidzein in Estrogenic and Neuroprotective Effects: A Development of Potential Health Products and Therapeutic Drugs against Alzheimer's Disease. Evidence-Based Complementary and Alternative Medicine : Ecam. 2013: 635694. PMID 24058373 DOI: 10.1155/2013/635694  0.36
2013 Xu SL, Bi CW, Choi RC, Zhu KY, Miernisha A, Dong TT, Tsim KW. Flavonoids induce the synthesis and secretion of neurotrophic factors in cultured rat astrocytes: a signaling response mediated by estrogen receptor. Evidence-Based Complementary and Alternative Medicine : Ecam. 2013: 127075. PMID 23878590 DOI: 10.1155/2013/127075  0.36
2013 Chen J, Li Z, Maiwulanjiang M, Zhang WL, Zhan JY, Lam CT, Zhu KY, Yao P, Choi RC, Lau DT, Dong TT, Tsim KW. Chemical and biological assessment of Ziziphus jujuba fruits from China: different geographical sources and developmental stages. Journal of Agricultural and Food Chemistry. 61: 7315-24. PMID 23841724 DOI: 10.1021/jf402379u  0.36
2013 Zhang WL, Choi RC, Zhan JY, Chen JP, Luk WK, Yao P, Dong TT, Tsim KW. Can Hedysari Radix replace Astragali Radix in Danggui Buxue Tang, a Chinese herbal decoction for woman aliment? Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. 20: 1076-81. PMID 23746954 DOI: 10.1016/j.phymed.2013.04.016  0.36
2013 Li CY, Lau DT, Dong TT, Zhang J, Choi RC, Wu HQ, Wang LY, Hong RS, Li SH, Song X, Yu T, Su WW, Tsim KW, He ZD. Dual-index evaluation of character changes in Panax ginseng C. A. Mey stored in different conditions. Journal of Agricultural and Food Chemistry. 61: 6568-73. PMID 23745668 DOI: 10.1021/jf400456w  0.36
2013 Zhan JY, Zhang WL, Zheng KY, Zhu KY, Chen JP, Chan PH, Dong TT, Choi RC, Lam H, Tsim KW, Lau DT. Chemical changes of Angelicae Sinensis Radix and Chuanxiong Rhizoma by wine treatment: chemical profiling and marker selection by gas chromatography coupled with triple quadrupole mass spectrometry. Chinese Medicine. 8: 12. PMID 23738580 DOI: 10.1186/1749-8546-8-12  0.36
2013 Yu H, Zhang WL, Ding X, Zheng KY, Ho CM, Tsim KW, Lee YK. Optimizing combinations of flavonoids deriving from astragali radix in activating the regulatory element of erythropoietin by a feedback system control scheme. Evidence-Based Complementary and Alternative Medicine : Ecam. 2013: 541436. PMID 23737836 DOI: 10.1155/2013/541436  0.36
2013 Choi RC, Chu GK, Siow NL, Yung AW, Yung LY, Lee PS, Lo CC, Simon J, Dong TT, Barnard EA, Tsim KW. Activation of UTP-sensitive P2Y2 receptor induces the expression of cholinergic genes in cultured cortical neurons: a signaling cascade triggered by Ca2+ mobilization and extracellular regulated kinase phosphorylation. Molecular Pharmacology. 84: 50-61. PMID 23592515 DOI: 10.1124/mol.112.084160  0.36
2013 Kong L, Choi RC, Tsim KW, Jing N, Nakayama DK, Wang Z. Distribution and expression of Kirre, an IgSF molecule, during postnatal development of rat cerebellum. Neuroscience Letters. 543: 22-6. PMID 23570724 DOI: 10.1016/j.neulet.2013.03.037  0.36
2013 Zhang WL, Zheng KY, Zhu KY, Zhan JY, Bi CW, Chen JP, Dong TT, Choi RC, Lau DT, Tsim KW. Chemical and biological assessment of angelica roots from different cultivated regions in a chinese herbal decoction danggui buxue tang. Evidence-Based Complementary and Alternative Medicine : Ecam. 2013: 483286. PMID 23476692 DOI: 10.1155/2013/483286  0.36
2013 Zhan JY, Zheng KY, Zhu KY, Zhang WL, Bi CW, Chen JP, Du CY, Dong TT, Lau DT, Tsim KW. Importance of wine-treated Angelica Sinensis Radix in Si Wu Tang, a traditional herbal formula for treating women's ailments. Planta Medica. 79: 533-7. PMID 23457023 DOI: 10.1055/s-0032-1328261  0.36
2013 Choi RC, Chen VP, Luk WK, Yung AW, Ng AH, Dong TT, Tsim KW. Expression of cAMP-responsive element binding proteins (CREBs) in fast- and slow-twitch muscles: a signaling pathway to account for the synaptic expression of collagen-tailed subunit (ColQ) of acetylcholinesterase at the rat neuromuscular junction. Chemico-Biological Interactions. 203: 282-6. PMID 23159887 DOI: 10.1016/j.cbi.2012.10.025  0.36
2013 Zha G, Chen VP, Luk WK, Zou X, Choi RC, Tsim KW. Characterization of acetylcholinesterase in Hong Kong oyster (Crassostrea hongkongensis) from South China Sea. Chemico-Biological Interactions. 203: 277-81. PMID 23000449 DOI: 10.1016/j.cbi.2012.09.005  0.36
2013 Chan GKL, Zhu KY, Chou DJY, Guo AJY, Dong TTX, Tsim KWK. Surveillance of nitrite level in cubilose: Evaluation of removal method and proposed origin of contamination Food Control. 34: 637-644. DOI: 10.1016/j.foodcont.2013.06.010  0.36
2012 Tsim K, Soreq H. Acetylcholinesterase: old questions and new developments. Frontiers in Molecular Neuroscience. 5: 101. PMID 23316131 DOI: 10.3389/fnmol.2012.00101  0.36
2012 Ip PS, Tsim KW, Chan K, Bauer R. Application of complementary and alternative medicine on neurodegenerative disorders: current status and future prospects. Evidence-Based Complementary and Alternative Medicine : Ecam. 2012: 930908. PMID 23304225 DOI: 10.1155/2012/930908  0.36
2012 Bi CW, Xu L, Tian XY, Liu J, Zheng KY, Lau CW, Lau DT, Choi RC, Dong TT, Huang Y, Tsim KW. Fo Shou San, an ancient Chinese herbal decoction, protects endothelial function through increasing endothelial nitric oxide synthase activity. Plos One. 7: e51670. PMID 23284736 DOI: 10.1371/journal.pone.0051670  0.36
2012 Chan PH, Zheng KY, Tsim KW, Lam H. Metabonomic analysis of water extracts from Chinese and American ginsengs by 1H nuclear magnetic resonance: identification of chemical profile for quality control. Chinese Medicine. 7: 25. PMID 23140520 DOI: 10.1186/1749-8546-7-25  0.36
2012 Xie QF, Xie JH, Dong TT, Su JY, Cai DK, Chen JP, Liu LF, Li YC, Lai XP, Tsim KW, Su ZR. Effect of a derived herbal recipe from an ancient Chinese formula, Danggui Buxue Tang, on ovariectomized rats. Journal of Ethnopharmacology. 144: 567-75. PMID 23036809 DOI: 10.1016/j.jep.2012.09.041  0.36
2012 Zhu KY, Mao QQ, Ip SP, Choi RC, Dong TT, Lau DT, Tsim KW. A standardized chinese herbal decoction, kai-xin-san, restores decreased levels of neurotransmitters and neurotrophic factors in the brain of chronic stress-induced depressive rats. Evidence-Based Complementary and Alternative Medicine : Ecam. 2012: 149256. PMID 22973399 DOI: 10.1155/2012/149256  0.36
2012 Zhang WL, Zheng KY, Zhu KY, Zhan JY, Bi CW, Chen JP, Du CY, Zhao KJ, Lau DT, Dong TT, Tsim KW. Chemical and biological assessment of Angelica herbal decoction: comparison of different preparations during historical applications. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. 19: 1042-8. PMID 22902230 DOI: 10.1016/j.phymed.2012.07.009  0.36
2012 Luk WK, Chen VP, Choi RC, Tsim KW. N-linked glycosylation of dimeric acetylcholinesterase in erythrocytes is essential for enzyme maturation and membrane targeting. The Febs Journal. 279: 3229-39. PMID 22805525 DOI: 10.1111/j.1742-4658.2012.08708.x  0.36
2012 Xu SL, Choi RC, Zhu KY, Leung KW, Guo AJ, Bi D, Xu H, Lau DT, Dong TT, Tsim KW. Isorhamnetin, A Flavonol Aglycone from Ginkgo biloba L., Induces Neuronal Differentiation of Cultured PC12 Cells: Potentiating the Effect of Nerve Growth Factor. Evidence-Based Complementary and Alternative Medicine : Ecam. 2012: 278273. PMID 22761636 DOI: 10.1155/2012/278273  0.36
2012 Chan WK, Chen VP, Luk WK, Choi RC, Tsim KW. N-linked glycosylation of proline-rich membrane anchor (PRiMA) is not required for assembly and trafficking of globular tetrameric acetylcholinesterase. Neuroscience Letters. 523: 71-5. PMID 22750213 DOI: 10.1016/j.neulet.2012.06.045  0.36
2012 Xu H, Su ZR, Huang W, Choi RC, Zheng YZ, Lau DT, Dong TT, Wang ZT, Tsim KW. Er Zhi Wan, an ancient herbal decoction for woman menopausal syndrome, activates the estrogenic response in cultured MCF-7 cells: an evaluation of compatibility in defining the optimized preparation method. Journal of Ethnopharmacology. 143: 109-15. PMID 22710293 DOI: 10.1016/j.jep.2012.06.009  0.36
2012 Zheng KY, Choi RC, Guo AJ, Bi CW, Zhu KY, Du CY, Zhang ZX, Lau DT, Dong TT, Tsim KW. The membrane permeability of Astragali Radix-derived formononetin and calycosin is increased by Angelicae Sinensis Radix in Caco-2 cells: a synergistic action of an ancient herbal decoction Danggui Buxue Tang. Journal of Pharmaceutical and Biomedical Analysis. 70: 671-9. PMID 22704738 DOI: 10.1016/j.jpba.2012.05.018  0.36
2012 Guo AJ, Choi RC, Zheng KY, Chen VP, Dong TT, Wang ZT, Vollmer G, Lau DT, Tsim KW. Kaempferol as a flavonoid induces osteoblastic differentiation via estrogen receptor signaling. Chinese Medicine. 7: 10. PMID 22546174 DOI: 10.1186/1749-8546-7-10  0.36
2012 Zheng KY, Zhang ZX, Guo AJ, Bi CW, Zhu KY, Xu SL, Zhan JY, Lau DT, Dong TT, Choi RC, Tsim KW. Salidroside stimulates the accumulation of HIF-1α protein resulted in the induction of EPO expression: a signaling via blocking the degradation pathway in kidney and liver cells. European Journal of Pharmacology. 679: 34-9. PMID 22309741 DOI: 10.1016/j.ejphar.2012.01.027  0.36
2012 Zhu KY, Leung KW, Ting AK, Wong ZC, Ng WY, Choi RC, Dong TT, Wang T, Lau DT, Tsim KW. Microfluidic chip based nano liquid chromatography coupled to tandem mass spectrometry for the determination of abused drugs and metabolites in human hair. Analytical and Bioanalytical Chemistry. 402: 2805-15. PMID 22281681 DOI: 10.1007/s00216-012-5711-6  0.36
2012 Wang T, Choi RC, Li J, Bi CW, Ran W, Chen X, Dong TT, Bi K, Tsim KW. Trillin, a steroidal saponin isolated from the rhizomes of Dioscorea nipponica, exerts protective effects against hyperlipidemia and oxidative stress. Journal of Ethnopharmacology. 139: 214-20. PMID 22100563 DOI: 10.1016/j.jep.2011.11.001  0.36
2012 Bi CW, Xu L, Zhang WL, Zhan JY, Fu Q, Zheng KY, Chen VP, Lau DT, Choi RC, Wang TJ, Dong TT, Tsim KW. Fo shou san, an ancient herbal decoction prepared from angelicae sinensis radix and chuanxiong rhizoma, induces erythropoietin expression: a signaling mediated by the reduced degradation of hypoxia-inducible factor in cultured liver cells. Planta Medica. 78: 122-7. PMID 22095261 DOI: 10.1055/s-0031-1280356  0.36
2012 Guo AJY, Choi RCY, Cheung AWH, Chen VP, Xu SL, Dong TTX, Chen JJ, Tsim KWK. Baicalin, a flavone, induces the differentiation of cultured osteoblasts: An action via the Wnt/β-catenin signaling pathway (Journal of Biological Chemistry (2011) 286 (27882-27893)) Journal of Biological Chemistry. 287: 6958. DOI: 10.1074/jbc.A111.236281  0.36
2011 Wu PK, Tai WC, Choi RC, Tsim KW, Zhou H, Liu X, Jiang ZH, Hsiao WL. Chemical and DNA authentication of taste variants of Gynostemma pentaphyllum herbal tea. Food Chemistry. 128: 70-80. PMID 25214331 DOI: 10.1016/j.foodchem.2011.02.078  0.36
2011 Liu H, Tsim KW, Chou GX, Wang JM, Ji LL, Wang ZT. Phenolic compounds from the rhizomes of Dioscorea bulbifera. Chemistry & Biodiversity. 8: 2110-6. PMID 22083923 DOI: 10.1002/cbdv.201000279  0.36
2011 Chen VP, Luk WK, Chan WK, Leung KW, Guo AJ, Chan GK, Xu SL, Choi RC, Tsim KW. Molecular Assembly and Biosynthesis of Acetylcholinesterase in Brain and Muscle: the Roles of t-peptide, FHB Domain, and N-linked Glycosylation. Frontiers in Molecular Neuroscience. 4: 36. PMID 22046147 DOI: 10.3389/fnmol.2011.00036  0.36
2011 Chen VP, Choi RC, Chan WK, Leung KW, Guo AJ, Chan GK, Luk WK, Tsim KW. The assembly of proline-rich membrane anchor (PRiMA)-linked acetylcholinesterase enzyme: glycosylation is required for enzymatic activity but not for oligomerization. The Journal of Biological Chemistry. 286: 32948-61. PMID 21795704 DOI: 10.1074/jbc.M111.261248  0.36
2011 Guo AJ, Choi RC, Cheung AW, Chen VP, Xu SL, Dong TT, Chen JJ, Tsim KW. Baicalin, a flavone, induces the differentiation of cultured osteoblasts: an action via the Wnt/beta-catenin signaling pathway. The Journal of Biological Chemistry. 286: 27882-93. PMID 21652696 DOI: 10.1074/jbc.M111.236281  0.36
2011 Zhan JY, Zheng KY, Zhu KY, Bi CW, Zhang WL, Du CY, Fu Q, Dong TT, Choi RC, Tsim KW, Lau DT. Chemical and biological assessment of Angelicae Sinensis Radix after processing with wine: an orthogonal array design to reveal the optimized conditions. Journal of Agricultural and Food Chemistry. 59: 6091-8. PMID 21520895 DOI: 10.1021/jf200728e  0.36
2011 Zhu KY, Fu Q, Leung KW, Wong ZC, Choi RC, Tsim KW. The establishment of a sensitive method in determining different neurotransmitters simultaneously in rat brains by using liquid chromatography-electrospray tandem mass spectrometry. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 879: 737-42. PMID 21377429 DOI: 10.1016/j.jchromb.2011.02.011  0.36
2011 Zheng KY, Choi RC, Cheung AW, Guo AJ, Bi CW, Zhu KY, Fu Q, Du Y, Zhang WL, Zhan JY, Duan R, Lau DT, Dong TT, Tsim KW. Flavonoids from Radix Astragali induce the expression of erythropoietin in cultured cells: a signaling mediated via the accumulation of hypoxia-inducible factor-1α. Journal of Agricultural and Food Chemistry. 59: 1697-704. PMID 21309574 DOI: 10.1021/jf104018u  0.36
2011 Kong L, Choi RC, Xie HQ, Wang X, Peng G, Xie Z, Tsim KW, Jing N. Expression of the IgSF protein Kirre in the rat central nervous system. Life Sciences. 88: 590-7. PMID 21277866 DOI: 10.1016/j.lfs.2011.01.014  0.36
2011 Zheng KY, Guo AJ, Bi CW, Zhu KY, Chan GK, Fu Q, Xu SL, Zhan JY, Lau DT, Dong TT, Choi RC, Tsim KW. The extract of Rhodiolae Crenulatae Radix et Rhizoma induces the accumulation of HIF-1α via blocking the degradation pathway in cultured kidney fibroblasts. Planta Medica. 77: 894-9. PMID 21157678 DOI: 10.1055/s-0030-1250627  0.36
2011 Zhu KY, Leung KW, Ting AK, Wong ZC, Fu Q, Ng WY, Choi RC, Dong TT, Wang T, Lau DT, Tsim KW. The establishment of a highly sensitive method in detecting ketamine and norketamine simultaneously in human hairs by HPLC-Chip-MS/MS. Forensic Science International. 208: 53-8. PMID 21112706 DOI: 10.1016/j.forsciint.2010.10.028  0.36
2011 Choi RC, Gao QT, Cheung AW, Zhu JT, Lau FT, Li J, Li WZ, Chu GK, Duan R, Cheung JK, Ding AW, Zhao KJ, Dong TT, Tsim KW. A chinese herbal decoction, danggui buxue tang, stimulates proliferation, differentiation and gene expression of cultured osteosarcoma cells: genomic approach to reveal specific gene activation. Evidence-Based Complementary and Alternative Medicine : Ecam. 2011: 307548. PMID 19131392 DOI: 10.1093/ecam/nen085  0.36
2010 Zhu KY, Fu Q, Xie HQ, Xu SL, Cheung AW, Zheng KY, Luk WK, Choi RC, Lau DT, Dong TT, Jiang ZY, Chen JJ, Tsim KW. Quality assessment of a formulated Chinese herbal decoction, Kaixinsan, by using rapid resolution liquid chromatography coupled with mass spectrometry: A chemical evaluation of different historical formulae. Journal of Separation Science. 33: 3666-74. PMID 21077129 DOI: 10.1002/jssc.201000498  0.36
2010 Choi RC, Jiang Z, Xie HQ, Cheung AW, Lau DT, Fu Q, Dong TT, Chen J, Wang Z, Tsim KW. Anti-oxidative effects of the biennial flower of Panax notoginseng against H2O2-induced cytotoxicity in cultured PC12 cells. Chinese Medicine. 5: 38. PMID 21029415 DOI: 10.1186/1749-8546-5-38  0.36
2010 Siow NL, Choi RC, Xie HQ, Kong LW, Chu GK, Chan GK, Simon J, Barnard EA, Tsim KW. ATP induces synaptic gene expressions in cortical neurons: transduction and transcription control via P2Y1 receptors. Molecular Pharmacology. 78: 1059-71. PMID 20847060 DOI: 10.1124/mol.110.066506  0.36
2010 Zheng KY, Choi RC, Xie HQ, Cheung AW, Guo AJ, Leung KW, Chen VP, Bi CW, Zhu KY, Chan GK, Fu Q, Lau DT, Dong TT, Zhao KJ, Tsim KW. The expression of erythropoietin triggered by danggui buxue tang, a Chinese herbal decoction prepared from radix Astragali and radix Angelicae Sinensis, is mediated by the hypoxia-inducible factor in cultured HEK293T cells. Journal of Ethnopharmacology. 132: 259-67. PMID 20723591 DOI: 10.1016/j.jep.2010.08.029  0.36
2010 Chen VP, Xie HQ, Chan WK, Leung KW, Chan GK, Choi RC, Bon S, Massoulié J, Tsim KW. The PRiMA-linked cholinesterase tetramers are assembled from homodimers: hybrid molecules composed of acetylcholinesterase and butyrylcholinesterase dimers are up-regulated during development of chicken brain. The Journal of Biological Chemistry. 285: 27265-78. PMID 20566626 DOI: 10.1074/jbc.M110.113647  0.36
2010 Wang T, Choi RC, Li J, Li J, Bi CW, Zang L, Liu Z, Dong TT, Bi K, Tsim KW. Antihyperlipidemic effect of protodioscin, an active ingredient isolated from the rhizomes of Dioscorea nipponica. Planta Medica. 76: 1642-6. PMID 20509104 DOI: 10.1055/s-0030-1249960  0.36
2010 Guo AJ, Xie HQ, Choi RC, Zheng KY, Bi CW, Xu SL, Dong TT, Tsim KW. Galangin, a flavonol derived from Rhizoma Alpiniae Officinarum, inhibits acetylcholinesterase activity in vitro. Chemico-Biological Interactions. 187: 246-8. PMID 20452337 DOI: 10.1016/j.cbi.2010.05.002  0.36
2010 Yung HS, Lai KH, Chow KB, Ip NY, Tsim KW, Wong YH, Wu Z, Wise H. Nerve growth factor-induced differentiation of PC12 cells is accompanied by elevated adenylyl cyclase activity. Neuro-Signals. 18: 32-42. PMID 20389133 DOI: 10.1159/000310977  0.36
2010 Lin HQ, Choi R, Chan KL, Ip D, Tsim KW, Wan DC. Differential gene expression profiling on the muscle of acetylcholinesterase knockout mice: a preliminary analysis. Chemico-Biological Interactions. 187: 120-3. PMID 20381477 DOI: 10.1016/j.cbi.2010.03.054  0.36
2010 Bi CW, Xie HQ, Xu L, Li J, Cheung AW, Zhu JT, Zheng YZ, Chen VP, Lau DT, Choi RC, Wang TJ, Dong TT, Tsim KW. Fo shou san, an ancient herbal decoction prepared from rhizoma chuanxiong and radix angelicae sinensis, stimulates the production of hemoglobin and erythropoietin in cultured cells. Planta Medica. 76: 1525-9. PMID 20309798 DOI: 10.1055/s-0029-1241003  0.36
2010 Xie HQ, Leung KW, Chen VP, Chan GK, Xu SL, Guo AJ, Zhu KY, Zheng KY, Bi CW, Zhan JY, Chan WK, Choi RC, Tsim KW. PRiMA directs a restricted localization of tetrameric AChE at synapses. Chemico-Biological Interactions. 187: 78-83. PMID 20178777 DOI: 10.1016/j.cbi.2010.02.018  0.36
2010 Chen VP, Xie HQ, Chan WK, Leung KW, Choi RC, Tsim KW. An induction effect of heat shock on the transcript of globular acetylcholinesterase in NG108-15 cells. Chemico-Biological Interactions. 187: 106-9. PMID 20176004 DOI: 10.1016/j.cbi.2010.02.024  0.36
2010 Choi RC, Zhu JT, Leung KW, Chu GK, Xie HQ, Chen VP, Zheng KY, Lau DT, Dong TT, Chow PC, Han YF, Wang ZT, Tsim KW. A flavonol glycoside, isolated from roots of Panax notoginseng, reduces amyloid-beta-induced neurotoxicity in cultured neurons: signaling transduction and drug development for Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 19: 795-811. PMID 20157237 DOI: 10.3233/JAD-2010-1293  0.36
2010 Xie HQ, Liang D, Leung KW, Chen VP, Zhu KY, Chan WK, Choi RC, Massoulié J, Tsim KW. Targeting acetylcholinesterase to membrane rafts: a function mediated by the proline-rich membrane anchor (PRiMA) in neurons. The Journal of Biological Chemistry. 285: 11537-46. PMID 20147288 DOI: 10.1074/jbc.M109.038711  0.36
2010 Zheng YZ, Choi RC, Li J, Xie HQ, Cheung AW, Duan R, Guo AJ, Zhu JT, Chen VP, Bi CW, Zhu Y, Lau DD, Dong TT, Lau BW, Tsim KW. Ligustilide suppresses the biological properties of Danggui Buxue Tang: a Chinese herbal decoction composed of radix astragali and radix angelica sinensis. Planta Medica. 76: 439-43. PMID 19847742 DOI: 10.1055/s-0029-1186222  0.36
2010 Tsim KW, Leung KW, Mok KW, Chen VP, Zhu KY, Zhu JT, Guo AJ, Bi CW, Zheng KY, Lau DT, Xie HQ, Choi RC. Expression and Localization of PRiMA-linked globular form acetylcholinesterase in vertebrate neuromuscular junctions. Journal of Molecular Neuroscience : Mn. 40: 40-6. PMID 19680821 DOI: 10.1007/s12031-009-9251-2  0.36
2010 Liu XP, Wang Y, Lan HY, Song AH, Tsim KWK, Dong TTX, Hu C. Synthesis and anti-inflammatory activity of a novel series of 9,10-dihydro-4H,8H-chromeno[8,7-e][1,3]oxazin-4-one derivatives Chemical Research in Chinese Universities. 26: 268-271.  0.36
2009 Chang XL, Jiang ZY, Ma YB, Zhang XM, Tsim KW, Chen JJ. Two new compounds from the roots of Ligusticum chuanxiong. Journal of Asian Natural Products Research. 11: 805-10. PMID 20183328 DOI: 10.1080/10286020903071068  0.36
2009 Zhu JT, Choi RC, Xie HQ, Zheng KY, Guo AJ, Bi CW, Lau DT, Li J, Dong TT, Lau BW, Chen JJ, Tsim KW. Hibifolin, a flavonol glycoside, prevents beta-amyloid-induced neurotoxicity in cultured cortical neurons. Neuroscience Letters. 461: 172-6. PMID 19539722 DOI: 10.1016/j.neulet.2009.06.010  0.36
2009 Mok MK, Leung KW, Xie HQ, Guo AJ, Chen VP, Zhu JT, Choi RC, Tsim KW. A new variant of proline-rich membrane anchor (PRiMA) of acetylcholinesterase in chicken: expression in different muscle fiber types. Neuroscience Letters. 461: 202-6. PMID 19539694 DOI: 10.1016/j.neulet.2009.06.015  0.36
2009 Zhu JT, Choi RC, Li J, Xie HQ, Bi CW, Cheung AW, Dong TT, Jiang ZY, Chen JJ, Tsim KW. Estrogenic and neuroprotective properties of scutellarin from Erigeron breviscapus: a drug against postmenopausal symptoms and Alzheimer's disease. Planta Medica. 75: 1489-93. PMID 19533578 DOI: 10.1055/s-0029-1185776  0.36
2009 Leung KW, Xie HQ, Chen VP, Mok MK, Chu GK, Choi RC, Tsim KW. Restricted localization of proline-rich membrane anchor (PRiMA) of globular form acetylcholinesterase at the neuromuscular junctions--contribution and expression from motor neurons. The Febs Journal. 276: 3031-42. PMID 19490106 DOI: 10.1111/j.1742-4658.2009.07022.x  0.36
2009 Cheung JK, Li J, Cheung AW, Zhu Y, Zheng KY, Bi CW, Duan R, Choi RC, Lau DT, Dong TT, Lau BW, Tsim KW. Cordysinocan, a polysaccharide isolated from cultured Cordyceps, activates immune responses in cultured T-lymphocytes and macrophages: signaling cascade and induction of cytokines. Journal of Ethnopharmacology. 124: 61-8. PMID 19446414 DOI: 10.1016/j.jep.2009.04.010  0.36
2009 Xie HQ, Choi RC, Leung KW, Chen VP, Chu GK, Tsim KW. Transcriptional regulation of proline-rich membrane anchor (PRiMA) of globular form acetylcholinesterase in neuron: an inductive effect of neuron differentiation. Brain Research. 1265: 13-23. PMID 19368807 DOI: 10.1016/j.brainres.2009.01.065  0.36
2009 Guo AJ, Choi RC, Cheung AW, Li J, Chen IX, Dong TT, Tsim KW, Lau BW. Stimulation of Apolipoprotein A-IV expression in Caco-2/TC7 enterocytes and reduction of triglyceride formation in 3T3-L1 adipocytes by potential anti-obesity Chinese herbal medicines. Chinese Medicine. 4: 5. PMID 19321011 DOI: 10.1186/1749-8546-4-5  0.36
2009 Li WZ, Li J, Bi CW, Cheung AW, Huang W, Duan R, Choi RC, Chen IS, Zhao KJ, Dong TT, Duan JA, Tsim KW. Can rhizoma chuanxiong replace radix Angelica sinensis in the traditional Chinese herbal decoction danggui buxue tang? Planta Medica. 75: 602-6. PMID 19204892 DOI: 10.1055/s-0029-1185361  0.36
2009 Ng YP, Wu Z, Wise H, Tsim KW, Wong YH, Ip NY. Differential and synergistic effect of nerve growth factor and cAMP on the regulation of early response genes during neuronal differentiation. Neuro-Signals. 17: 111-20. PMID 19176979 DOI: 10.1159/000197391  0.36
2009 Li J, Li WZ, Huang W, Cheung AW, Bi CW, Duan R, Guo AJ, Dong TT, Tsim KW. Quality evaluation of Rhizoma Belamcandae (Belamcanda chinensis (L.) DC.) by using high-performance liquid chromatography coupled with diode array detector and mass spectrometry. Journal of Chromatography. A. 1216: 2071-8. PMID 18550076 DOI: 10.1016/j.chroma.2008.05.082  0.36
2009 Chan KN, Lau CC, Chow KL, Ko KM, Tsim KWK, Ng KM. Effect of extraction solvent on the bioactivity of an herbal formulation Industrial and Engineering Chemistry Research. 48: 4852-4857. DOI: 10.1021/ie8012538  0.36
2008 Lau FT, Choi RC, Xie HQ, Leung KW, Chen VP, Zhu JT, Bi CW, Chu GK, Tsim KW. Myocyte enhancer factor 2 mediates acetylcholine-induced expression of acetylcholinesterase-associated collagen ColQ in cultured myotubes. Molecular and Cellular Neurosciences. 39: 429-38. PMID 18718538 DOI: 10.1016/j.mcn.2008.07.018  0.36
2008 Doctor BP, Tsim KW, Siow NL. The IXth International Meeting on Cholinesterases, Suzhou, People's Republic of China, 6 to 10 May 2007. Chemico-Biological Interactions. 175: 1-2. PMID 18582448 DOI: 10.1016/j.cbi.2008.06.001  0.36
2008 Xie HQ, Leung KW, Chen VP, Lau FT, Liu LS, Choi RC, Tsim KW. The promoter activity of proline-rich membrane anchor (PRiMA) of globular form acetylcholinesterase in muscle: suppressive roles of myogenesis and innervating nerve. Chemico-Biological Interactions. 175: 79-82. PMID 18561906 DOI: 10.1016/j.cbi.2008.04.028  0.36
2008 Choi RC, Mok MK, Cheung AW, Siow NL, Xie HQ, Tsim KW. Regulation of PRiMA-linked G(4) AChE by a cAMP-dependent signaling pathway in cultured rat pheochromocyoma PC12 cells. Chemico-Biological Interactions. 175: 76-8. PMID 18514641 DOI: 10.1016/j.cbi.2008.04.007  0.36
2008 Tsim KW, Choi RC, Xie HQ, Zhu JT, Leung KW, Lau FT, Chu GK, Chen VP, Mok MK, Cheung AW, Bi CW. Transcriptional control of different subunits of AChE in muscles: signals triggered by the motor nerve-derived factors. Chemico-Biological Interactions. 175: 58-63. PMID 18514177 DOI: 10.1016/j.cbi.2008.04.014  0.36
2008 Gao QT, Cheung JK, Choi RC, Cheung AW, Li J, Jiang ZY, Duan R, Zhao KJ, Ding AW, Dong TT, Tsim KW. A Chinese herbal decoction prepared from Radix Astragali and Radix Angelicae Sinensis induces the expression of erythropoietin in cultured Hep3B cells. Planta Medica. 74: 392-5. PMID 18484529 DOI: 10.1055/s-2008-1034322  0.36
2008 Choi RC, Simon J, Tsim KW, Barnard EA. Constitutive and agonist-induced dimerizations of the P2Y1 receptor: relationship to internalization and scaffolding. The Journal of Biological Chemistry. 283: 11050-63. PMID 18270199 DOI: 10.1074/jbc.M709266200  0.36
2008 Fu H, Li W, Luo J, Lee NT, Li M, Tsim KW, Pang Y, Youdim MB, Han Y. Promising anti-Alzheimer's dimer bis(7)-tacrine reduces beta-amyloid generation by directly inhibiting BACE-1 activity. Biochemical and Biophysical Research Communications. 366: 631-6. PMID 18039469 DOI: 10.1016/j.bbrc.2007.11.068  0.36
2008 Li J, Li WZM, Zhao KJ, Huang W, Bi CWC, Duan R, Dong TTX, Tsim KWK. Huangqi (Astragalus spp.) Pharmacological Activity-Based Quality Control of Chinese Herbs. 235-250.  0.36
2007 Gao Q, Li J, Cheung JK, Duan J, Ding A, Cheung AW, Zhao K, Li WZ, Dong TT, Tsim KW. Verification of the formulation and efficacy of Danggui Buxue Tang (a decoction of Radix Astragali and Radix Angelicae Sinensis): an exemplifying systematic approach to revealing the complexity of Chinese herbal medicine formulae. Chinese Medicine. 2: 12. PMID 18045504 DOI: 10.1186/1749-8546-2-12  0.36
2007 Gao QT, Cheung JK, Li J, Jiang ZY, Chu GK, Duan R, Cheung AW, Zhao KJ, Choi RC, Dong TT, Tsim KW. A Chinese herbal decoction, Danggui Buxue Tang, activates extracellular signal-regulated kinase in cultured T-lymphocytes. Febs Letters. 581: 5087-93. PMID 17923124 DOI: 10.1016/j.febslet.2007.09.053  0.36
2007 Ng KL, Lam CC, Fu Z, Han YF, Tsim KW, Wong WK. Cloning and characterization of the yjeA gene, encoding a novel deoxyribonuclease, from Bacillus subtilis. Journal of Biochemistry. 142: 647-54. PMID 17878218 DOI: 10.1093/jb/mvm177  0.36
2007 Li J, Dong X, Jiang Y, Gao Q, Jiang Z, Cheung AW, Duan R, Dong TT, Tu P, Tsim KW. Simultaneous determination of phenols in Radix Polygalae by high performance liquid chromatography: quality assurance of herbs from different regions and seasons. Journal of Separation Science. 30: 2583-9. PMID 17722189 DOI: 10.1002/jssc.200700118  0.36
2007 Fu H, Li W, Liu Y, Lao Y, Liu W, Chen C, Yu H, Lee NT, Chang DC, Li P, Pang Y, Tsim KW, Li M, Han Y. Mitochondrial proteomic analysis and characterization of the intracellular mechanisms of bis(7)-tacrine in protecting against glutamate-induced excitotoxicity in primary cultured neurons. Journal of Proteome Research. 6: 2435-46. PMID 17530875 DOI: 10.1021/pr060615g  0.36
2007 Choi RC, Ting AK, Lau FT, Xie HQ, Leung KW, Chen VP, Siow NL, Tsim KW. Calcitonin gene-related peptide induces the expression of acetylcholinesterase-associated collagen ColQ in muscle: a distinction in driving two different promoters between fast- and slow-twitch muscle fibers. Journal of Neurochemistry. 102: 1316-28. PMID 17488278 DOI: 10.1111/j.1471-4159.2007.4630.x  0.36
2007 Chiu PY, Leung HY, Siu AH, Poon MK, Dong TT, Tsim KW, Ko KM. Dang-Gui Buxue Tang protects against oxidant injury by enhancing cellular glutathione in H9c2 cells: role of glutathione synthesis and regeneration. Planta Medica. 73: 134-41. PMID 17325989 DOI: 10.1055/s-2007-967135  0.36
2007 Xie HQ, Choi RC, Leung KW, Siow NL, Kong LW, Lau FT, Peng HB, Tsim KW. Regulation of a transcript encoding the proline-rich membrane anchor of globular muscle acetylcholinesterase. The suppressive roles of myogenesis and innervating nerves. The Journal of Biological Chemistry. 282: 11765-75. PMID 17324938 DOI: 10.1074/jbc.M608265200  0.36
2007 Zhu JT, Choi RC, Chu GK, Cheung AW, Gao QT, Li J, Jiang ZY, Dong TT, Tsim KW. Flavonoids possess neuroprotective effects on cultured pheochromocytoma PC12 cells: a comparison of different flavonoids in activating estrogenic effect and in preventing beta-amyloid-induced cell death. Journal of Agricultural and Food Chemistry. 55: 2438-45. PMID 17323972 DOI: 10.1021/jf063299z  0.36
2007 Li W, Xue J, Niu C, Fu H, Lam CS, Luo J, Chan HH, Xue H, Kan KK, Lee NT, Li C, Pang Y, Li M, Tsim KW, Jiang H, et al. Synergistic neuroprotection by bis(7)-tacrine via concurrent blockade of N-methyl-D-aspartate receptors and neuronal nitric-oxide synthase. Molecular Pharmacology. 71: 1258-67. PMID 17299028 DOI: 10.1124/mol.106.029108  0.36
2007 Gao QT, Choi RC, Cheung AW, Zhu JT, Li J, Chu GK, Duan R, Cheung JK, Jiang ZY, Dong XB, Zhao KJ, Dong TT, Tsim KW. Danggui buxue tang--a Chinese herbal decoction activates the phosphorylations of extracellular signal-regulated kinase and estrogen receptor alpha in cultured MCF-7 cells. Febs Letters. 581: 233-40. PMID 17187784 DOI: 10.1016/j.febslet.2006.12.018  0.36
2007 Zhu H, Gao W, Jiang H, Jin QH, Shi YF, Tsim KW, Zhang XJ. Regulation of acetylcholinesterase expression by calcium signaling during calcium ionophore A23187- and thapsigargin-induced apoptosis. The International Journal of Biochemistry & Cell Biology. 39: 93-108. PMID 17000130 DOI: 10.1016/j.biocel.2006.06.012  0.36
2006 Tsim KW, Xie HQ, Ting AK, Siow NL, Ling KK, Kong LW. Transcriptional control of different acetylcholinesterase subunits in formation and maintenance of vertebrate neuromuscular junctions. Journal of Molecular Neuroscience : Mn. 30: 189-92. PMID 17192673 DOI: 10.1385/JMN:30:1:189  0.36
2006 Wan DC, Zhang X, Siow NL, Xie HQ, Tsim KW. Chick acetylcholinesterase promoter regulation. Journal of Molecular Neuroscience : Mn. 30: 33-4. PMID 17192617 DOI: 10.1385/JMN:30:1:33  0.36
2006 Ji ZN, Zhao WY, Liao GR, Choi RC, Lo CK, Dong TT, Tsim KW. In vitro estrogenic activity of formononetin by two bioassay systems. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology. 22: 578-84. PMID 17135037 DOI: 10.1080/09513590600924345  0.36
2006 Wan JB, Li P, Li S, Wang Y, Dong TT, Tsim KW. Simultaneous determination of 11 saponins in Panax notoginseng using HPLC-ELSD and pressurized liquid extraction. Journal of Separation Science. 29: 2190-6. PMID 17069249 DOI: 10.1002/jssc.200600103  0.36
2006 Wu X, Dai H, Huang L, Gao X, Tsim KW, Tu P. A fructan, from Radix ophiopogonis, stimulates the proliferation of cultured lymphocytes: structural and functional analyses. Journal of Natural Products. 69: 1257-60. PMID 16989515 DOI: 10.1021/np060033d  0.36
2006 Gao QT, Cheung JK, Li J, Chu GK, Duan R, Cheung AW, Zhao KJ, Dong TT, Tsim KW. A Chinese herbal decoction, Danggui Buxue Tang, prepared from Radix Astragali and Radix Angelicae Sinensis stimulates the immune responses. Planta Medica. 72: 1227-31. PMID 16902872 DOI: 10.1055/s-2006-947186  0.36
2006 Fu H, Li W, Lao Y, Luo J, Lee NT, Kan KK, Tsang HW, Tsim KW, Pang Y, Li Z, Chang DC, Li M, Han Y. Bis(7)-tacrine attenuates beta amyloid-induced neuronal apoptosis by regulating L-type calcium channels. Journal of Neurochemistry. 98: 1400-10. PMID 16771827 DOI: 10.1111/j.1471-4159.2006.03960.x  0.36
2006 Li SP, Zhang GH, Zeng Q, Huang ZG, Wang YT, Dong TT, Tsim KW. Hypoglycemic activity of polysaccharide, with antioxidation, isolated from cultured Cordyceps mycelia. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. 13: 428-33. PMID 16716913 DOI: 10.1016/j.phymed.2005.02.002  0.36
2006 Mak DH, Chiu PY, Dong TT, Tsim KW, Ko KM. Dang-Gui Buxue Tang produces a more potent cardioprotective effect than its component herb extracts and enhances glutathione status in rat heart mitochondria and erythrocytes. Phytotherapy Research : Ptr. 20: 561-7. PMID 16619337 DOI: 10.1002/ptr.1904  0.36
2006 Dong TT, Zhao KJ, Gao QT, Ji ZN, Zhu TT, Li J, Duan R, Cheung AW, Tsim KW. Chemical and biological assessment of a chinese herbal decoction containing Radix Astragali and Radix Angelicae Sinensis: Determination of drug ratio in having optimized properties. Journal of Agricultural and Food Chemistry. 54: 2767-74. PMID 16569074 DOI: 10.1021/jf053163l  0.36
2006 Ji ZN, Dong TT, Ye WC, Choi RC, Lo CK, Tsim KW. Ginsenoside Re attenuate beta-amyloid and serum-free induced neurotoxicity in PC12 cells. Journal of Ethnopharmacology. 107: 48-52. PMID 16564145 DOI: 10.1016/j.jep.2006.02.004  0.36
2006 Li W, Lee NT, Fu H, Kan KK, Pang Y, Li M, Tsim KW, Li X, Han Y. Neuroprotection via inhibition of nitric oxide synthase by bis(7)-tacrine. Neuroreport. 17: 471-4. PMID 16543809 DOI: 10.1097/01.wnr.0000209014.09094.72  0.36
2006 Li SP, Yang FQ, Tsim KW. Quality control of Cordyceps sinensis, a valued traditional Chinese medicine. Journal of Pharmaceutical and Biomedical Analysis. 41: 1571-84. PMID 16504449 DOI: 10.1016/j.jpba.2006.01.046  0.36
2005 Xie HQ, Siow NL, Peng HB, Massoulié J, Tsim KW. Regulation of PRiMA: membrane anchor of acetylcholinesterase (AChE) in neuron and muscle. Chemico-Biological Interactions. 157: 432. PMID 16429581 DOI: 10.1016/j.cbi.2005.10.093  0.36
2005 Siow NL, Xie HQ, Choi RC, Tsim KW. ATP induces the post-synaptic gene expression in neuron-neuron synapses: Transcriptional regulation of AChE catalytic subunit. Chemico-Biological Interactions. 157: 423-6. PMID 16429571 DOI: 10.1016/j.cbi.2005.10.088  0.36
2005 Wu XM, Gao XM, Tsim KW, Tu PF. An arabinogalactan isolated from the stems of Cistanche deserticola induces the proliferation of cultured lymphocytes. International Journal of Biological Macromolecules. 37: 278-82. PMID 16343610 DOI: 10.1016/j.ijbiomac.2005.11.001  0.36
2005 Ting AK, Siow NL, Kong LW, Tsim KW. Transcriptional regulation of acetylcholinesterase-associated collagen ColQ in fast- and slow-twitch muscle fibers. Chemico-Biological Interactions. 157: 63-70. PMID 16256971 DOI: 10.1016/j.cbi.2005.10.009  0.36
2005 Dong TT, Zhao KJ, Huang WZ, Leung KW, Tsim KW. Orthogonal array design in optimizing the extraction efficiency of active constituents from roots of Panax notoginseng. Phytotherapy Research : Ptr. 19: 684-8. PMID 16177971 DOI: 10.1002/ptr.1728  0.36
2005 Xia Q, Zhao KJ, Huang ZG, Zhang P, Dong TT, Li SP, Tsim KW. Molecular genetic and chemical assessment of Rhizoma Curcumae in China. Journal of Agricultural and Food Chemistry. 53: 6019-26. PMID 16028990 DOI: 10.1021/jf0508495  0.36
2005 Carles M, Cheung MK, Moganti S, Dong TT, Tsim KW, Ip NY, Sucher NJ. A DNA microarray for the authentication of toxic traditional Chinese medicinal plants. Planta Medica. 71: 580-4. PMID 15971136 DOI: 10.1055/s-2005-864166  0.36
2005 Yang FQ, Li SP, Chen Y, Lao SC, Wang YT, Dong TT, Tsim KW. Identification and quantitation of eleven sesquiterpenes in three species of Curcuma rhizomes by pressurized liquid extraction and gas chromatography-mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. 39: 552-8. PMID 15946818 DOI: 10.1016/j.jpba.2005.05.001  0.36
2005 Ling KK, Siow NL, Choi RC, Tsim KW. ATP potentiates the formation of AChR aggregate in the co-culture of NG108-15 cells with C2C12 myotubes. Febs Letters. 579: 2469-74. PMID 15848190 DOI: 10.1016/j.febslet.2005.03.054  0.36
2005 Li W, Pi R, Chan HH, Fu H, Lee NT, Tsang HW, Pu Y, Chang DC, Li C, Luo J, Xiong K, Li Z, Xue H, Carlier PR, Pang Y, ... Tsim KW, et al. Novel dimeric acetylcholinesterase inhibitor bis7-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptors. The Journal of Biological Chemistry. 280: 18179-88. PMID 15710623 DOI: 10.1074/jbc.M411085200  0.36
2005 Cui XM, Xu LS, Wang Q, Chen ZJ, Dong TX, Tsim KWK. Determination of dencichine in Radix Notoginseng Chinese Pharmaceutical Journal. 40: 1017-1019.  0.36
2004 Song ZH, Ji ZN, Lo CK, Dong TT, Zhao KJ, Li OT, Haines CJ, Kung SD, Tsim KW. Chemical and biological assessment of a traditional chinese herbal decoction prepared from Radix Astragali and Radix Angelicae Sinensis: orthogonal array design to optimize the extraction of chemical constituents. Planta Medica. 70: 1222-7. PMID 15643561 DOI: 10.1055/s-2004-835855  0.36
2004 Li SP, Song ZH, Dong TT, Ji ZN, Lo CK, Zhu SQ, Tsim KW. Distinction of water-soluble constituents between natural and cultured Cordyceps by capillary electrophoresis. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. 11: 684-90. PMID 15636186 DOI: 10.1016/j.phymed.2003.07.011  0.36
2004 Tung EK, Choi RC, Siow NL, Jiang JX, Ling KK, Simon J, Barnard EA, Tsim KW. P2Y2 receptor activation regulates the expression of acetylcholinesterase and acetylcholine receptor genes at vertebrate neuromuscular junctions. Molecular Pharmacology. 66: 794-806. PMID 15258260 DOI: 10.1124/mol.104.003269  0.36
2004 Li SP, Li P, Lai CM, Gong YX, Kan KK, Dong TT, Tsim KW, Wang YT. Simultaneous determination of ergosterol, nucleosides and their bases from natural and cultured Cordyceps by pressurised liquid extraction and high-performance liquid chromatography. Journal of Chromatography. A. 1036: 239-43. PMID 15146928 DOI: 10.1016/j.chroma.2004.02.080  0.36
2004 Ling KK, Siow NL, Choi RC, Ting AK, Kong LW, Tsim KW. ATP potentiates agrin-induced AChR aggregation in cultured myotubes: activation of RhoA in P2Y1 nucleotide receptor signaling at vertebrate neuromuscular junctions. The Journal of Biological Chemistry. 279: 31081-8. PMID 15145960 DOI: 10.1074/jbc.M403316200  0.36
2004 Lee HH, Choi RC, Ting AK, Siow NL, Jiang JX, Massoulié J, Tsim KW. Transcriptional regulation of acetylcholinesterase-associated collagen ColQ: differential expression in fast and slow twitch muscle fibers is driven by distinct promoters. The Journal of Biological Chemistry. 279: 27098-107. PMID 15102835 DOI: 10.1074/jbc.M402596200  0.36
2004 Lao SC, Li SP, Kan KKW, Li P, Wan JB, Wang YT, Dong TTX, Tsim KWK. Identification and quantification of 13 components in Angelica sinensis (Danggui) by gas chromatography-mass spectrometry coupled with pressurized liquid extraction Analytica Chimica Acta. 526: 131-137. DOI: 10.1016/j.aca.2004.09.050  0.36
2003 Tsim KW, Choi RC, Siow NL, Cheng AW, Ling KK, Jiang JX, Tung EK, Lee HH, Xie QH, Simon J, Barnard EA. ATP induces post-synaptic gene expressions in vertebrate skeletal neuromuscular junctions. Journal of Neurocytology. 32: 603-17. PMID 15034256 DOI: 10.1023/B:NEUR.0000020613.25367.78  0.36
2003 Zhao KJ, Dong TT, Cui XM, Tu PF, Tsim KW. Genetic distinction of radix adenophorae from its adulterants by the DNA sequence of 5S-rRNA spacer domains. The American Journal of Chinese Medicine. 31: 919-26. PMID 14992544 DOI: 10.1142/S0192415X03001612  0.36
2003 Dong TT, Cui XM, Song ZH, Zhao KJ, Ji ZN, Lo CK, Tsim KW. Chemical assessment of roots of Panax notoginseng in China: regional and seasonal variations in its active constituents. Journal of Agricultural and Food Chemistry. 51: 4617-23. PMID 14705886 DOI: 10.1021/jf034229k  0.36
2003 Dong TT, Ma XQ, Clarke C, Song ZH, Ji ZN, Lo CK, Tsim KW. Phylogeny of Astragalus in China: molecular evidence from the DNA sequences of 5S rRNA spacer, ITS, and 18S rRNA. Journal of Agricultural and Food Chemistry. 51: 6709-14. PMID 14582964 DOI: 10.1021/jf034278x  0.36
2003 Jiang JX, Choi RC, Siow NL, Lee HH, Wan DC, Tsim KW. Muscle induces neuronal expression of acetylcholinesterase in neuron-muscle co-culture: transcriptional regulation mediated by cAMP-dependent signaling. The Journal of Biological Chemistry. 278: 45435-44. PMID 12963741 DOI: 10.1074/jbc.M306320200  0.36
2003 Li SP, Zhao KJ, Ji ZN, Song ZH, Dong TT, Lo CK, Cheung JK, Zhu SQ, Tsim KW. A polysaccharide isolated from Cordyceps sinensis, a traditional Chinese medicine, protects PC12 cells against hydrogen peroxide-induced injury. Life Sciences. 73: 2503-13. PMID 12954458 DOI: 10.1016/S0024-3205(03)00652-0  0.36
2003 Cui XM, Lo CK, Yip KL, Dong TT, Tsim KW. Authentication of Panax notoginseng by 5S-rRNA spacer domain and random amplified polymorphic DNA (RAPD) analysis. Planta Medica. 69: 584-6. PMID 12865989 DOI: 10.1055/s-2003-40632  0.36
2003 Choi RC, Siow NL, Cheng AW, Ling KK, Tung EK, Simon J, Barnard EA, Tsim KW. ATP acts via P2Y1 receptors to stimulate acetylcholinesterase and acetylcholine receptor expression: transduction and transcription control. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 4445-56. PMID 12805285  0.36
2003 Zhao KJ, Dong TT, Tu PF, Song ZH, Lo CK, Tsim KW. Molecular genetic and chemical assessment of radix Angelica (Danggui) in China. Journal of Agricultural and Food Chemistry. 51: 2576-83. PMID 12696940 DOI: 10.1021/jf026178h  0.36
2003 Cheng AW, Kong LW, Tung EK, Siow NL, Choi RC, Zhu SQ, Peng BH, Tsim KW. cDNA encodes Xenopus P2Y(1) nucleotide receptor: expression at the neuromuscular junctions. Neuroreport. 14: 351-7. PMID 12634482 DOI: 10.1097/01.wnr.0000058033.29600.a3  0.36
2003 Ding K, Fang JN, Dong T, Tsim KW, Wu H. Characterization of a rhamnogalacturonan and a xyloglucan from neriumindicum and their activities on PC12 pheochromocytoma cells. Journal of Natural Products. 66: 7-10. PMID 12542335 DOI: 10.1021/np020118o  0.36
2003 Barnard EA, Simon J, Tsim KWK, Filippov AK, Brown DA. Signalling pathways and ion channel regulations of P2Y receptors Drug Development Research. 59: 36-48. DOI: 10.1002/ddr.10200  0.36
2002 Ma XQ, Shi Q, Duan JA, Dong TT, Tsim KW. Chemical analysis of Radix Astragali (Huangqi) in China: a comparison with its adulterants and seasonal variations. Journal of Agricultural and Food Chemistry. 50: 4861-6. PMID 12166972  0.48
2002 Siow NL, Choi RC, Cheng AW, Jiang JX, Wan DC, Zhu SQ, Tsim KW. A cyclic AMP-dependent pathway regulates the expression of acetylcholinesterase during myogenic differentiation of C2C12 cells. The Journal of Biological Chemistry. 277: 36129-36. PMID 12140295 DOI: 10.1074/jbc.M206498200  0.36
2002 Li SP, Su ZR, Dong TT, Tsim KW. The fruiting body and its caterpillar host of Cordyceps sinensis show close resemblance in main constituents and anti-oxidation activity. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. 9: 319-24. PMID 12120813 DOI: 10.1078/0944-7113-00134  0.48
2002 Tsim KW, Barnard EA. The signaling pathways mediated by P2Y nucleotide receptors in the formation and maintenance of the skeletal neuromuscular junction. Neuro-Signals. 11: 58-64. PMID 11943883 DOI: 10.1159/000057322  0.36
2002 Cui Xm, Dong Tx, Chen Zj, Wang Cl, Tsim KWK. Studies on the change of polysaccharides in Panax notoginseng collected at different times and from regions Chinese Pharmaceutical Journal. 37: 818-820.  0.36
2001 Li SP, Li P, Ji H, Zhang P, Dong TT, Tsim KW. [The contents and their change of nucleosides from natural Cordyceps sinensis and cultured cordyceps mycelia]. Yao Xue Xue Bao = Acta Pharmaceutica Sinica. 36: 436-9. PMID 12585128  0.48
2001 Choi RC, Man ML, Ling KK, Ip NY, Simon J, Barnard EA, Tsim KW. Expression of the P2Y1 nucleotide receptor in chick muscle: its functional role in the regulation of acetylcholinesterase and acetylcholine receptor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 9224-34. PMID 11717356  0.36
2001 Li SP, Li P, Dong TT, Tsim KW. Anti-oxidation activity of different types of natural Cordyceps sinensis and cultured Cordyceps mycelia. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. 8: 207-12. PMID 11417914 DOI: 10.1078/0944-7113-00030  0.48
2001 Ma XQ, Zhu DY, Li SP, Dong TT, Tsim KW. Authentic identification of stigma Croci (stigma of Crocus sativus) from its adulterants by molecular genetic analysis. Planta Medica. 67: 183-6. PMID 11301875 DOI: 10.1055/s-2001-11533  0.48
2001 Fu AK, Fu WY, Cheung J, Tsim KW, Ip FC, Wang JH, Ip NY. Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction. Nature Neuroscience. 4: 374-81. PMID 11276227 DOI: 10.1038/86019  0.36
2001 Li SP, Li P, Dong TT, Tsim KW. Determination of nucleosides in natural Cordyceps sinensis and cultured Cordyceps mycelia by capillary electrophoresis. Electrophoresis. 22: 144-50. PMID 11197164 DOI: 10.1002/1522-2683(200101)22:1<144::AID-ELPS144>3.0.CO;2-T  0.48
2000 Ma XQ, Duan JA, Zhu DY, Dong TT, Tsim KW. Species identification of Radix Astragali (Huangqi) by DNA sequence of its 5S-rRNA spacer domain. Phytochemistry. 54: 363-8. PMID 10897476  0.48
2000 Wang Y, Zhou K, Xu L, Dong TT, Tsim KW. Authentication of an animal crude drug, Zaocys, by diagnostic PCR. Biological & Pharmaceutical Bulletin. 23: 585-8. PMID 10823669  0.48
1999 Yang JF, Zhou H, Choi RC, Ip NY, Peng HB, Tsim KW. A cysteine-rich form of Xenopus neuregulin induces the expression of acetylcholine receptors in cultured myotubes. Molecular and Cellular Neurosciences. 13: 415-29. PMID 10383827 DOI: 10.1006/mcne.1999.0759  0.36
1999 Cai ZH, Li P, Dong TT, Tsim KW. Molecular diversity of 5S-rRNA spacer domain in Fritillaria species revealed by PCR analysis. Planta Medica. 65: 360-4. PMID 10364844 DOI: 10.1055/s-1999-14003  0.48
1999 Wan DC, Law LK, Ip DT, Cheung WT, Ho WK, Tsim KW, Kay R, Woo J, Pang CP. Lack of allelic association of dopamine D4 receptor gene polymorphisms with Parkinson's disease in a Chinese population. Movement Disorders : Official Journal of the Movement Disorder Society. 14: 225-9. PMID 10091613 DOI: 10.1002/1531-8257(199903)14:2<225::AID-MDS1004>3.0.CO;2-7  0.36
1998 Yang JF, Zhou H, Pun S, Ip NY, Peng HB, Tsim KW. Cloning of cDNAs encoding xenopus neuregulin: expression in myotomal muscle during embryo development. Brain Research. Molecular Brain Research. 58: 59-73. PMID 9685585 DOI: 10.1016/S0169-328X(98)00085-0  0.36
1998 Choi RC, Yung LY, Dong TT, Wan DC, Wong YH, Tsim KW. The calcitonin gene-related peptide-induced acetylcholinesterase synthesis in cultured chick myotubes is mediated by cyclic AMP. Journal of Neurochemistry. 71: 152-60. PMID 9648861  0.48
1997 Fu AK, Ip FC, Lai KO, Tsim KW, Ip NY. Muscle-derived neurotrophin-3 increases the aggregation of acetylcholine receptors in neuron-muscle co-cultures. Neuroreport. 8: 3895-900. PMID 9462462  0.36
1997 Pun S, Yang JF, Ng YP, Tsim KW. NG108-15 cells express neuregulin that induces AChR alpha-subunit synthesis in cultured myotubes. Febs Letters. 418: 275-81. PMID 9428727 DOI: 10.1016/S0014-5793(97)01369-0  0.36
1997 Choi RC, Pun S, Dong TT, Wan DC, Tsim KW. NG108-15 cells induce the expression of muscular acetylcholinesterase when co-cultured with myotubes. Neuroscience Letters. 236: 167-70. PMID 9406763 DOI: 10.1016/S0304-3940(97)00789-1  0.36
1997 Pun S, Ng YP, Yang JF, Ip NY, Tsim KW. Agrin-deficient myotube retains its acetylcholine receptor aggregation ability when challenged with agrin. Journal of Neurochemistry. 69: 2555-63. PMID 9375689  0.36
1997 Pun S, Tsim KW. Antisense agrin cDNA transfection blocks neuroblastoma cell-induced acetylcholine receptor aggregation when co-cultured with myotubes. Molecular and Cellular Neurosciences. 10: 87-99. PMID 9361290 DOI: 10.1006/mcne.1997.0637  0.36
1997 Wan DC, Ng YP, Choi RC, Cheung PW, Dong TT, Tsim KW. Denervation decreases the ipsilateral expression of AChE in chick lumbaric motor neurons. Neuroscience Letters. 232: 83-6. PMID 9302092  0.48
1997 Ng YP, Pun S, Yang JF, Ip NY, Tsim KW. Chick muscle expresses various ARIA isoforms: regulation during development, denervation, and regeneration. Molecular and Cellular Neurosciences. 9: 132-43. PMID 9245497 DOI: 10.1006/mcne.1997.0613  0.36
1997 Yang JF, Ng YP, Pun S, Ip NY, Tsim KW. The EGF-like domain of chick acetylcholine receptor-inducing activity (ARIA) contains its full biological activity. Febs Letters. 403: 163-7. PMID 9042959 DOI: 10.1016/S0014-5793(97)00044-6  0.36
1997 Tsim KW, Choi RC, Dong TT, Wan DC. A globular, not asymmetric, form of acetylcholinesterase is expressed in chick motor neurons: down-regulation toward maturity and after denervation. Journal of Neurochemistry. 68: 479-87. PMID 9003032  0.48
1996 Choi RC, Leung PW, Dong TT, Wan DC, Tsim KW. Calcitonin gene-related peptide increases the expression of acetylcholinesterase in cultured chick myotubes. Neuroscience Letters. 217: 165-8. PMID 8916098  0.48
1996 Ip FC, Fu AK, Tsim KW, Ip NY. Differential expression of ciliary neurotrophic factor receptor in skeletal muscle of chick and rat after nerve injury. Journal of Neurochemistry. 67: 1607-12. PMID 8858945  0.36
1996 Reiss Y, Kröger S, Grassi J, Tsim KW, Willbold E, Layer PG. Extracellular and asymmetric forms of acetylcholinesterase are expressed on cholinergic and noncholinergic terminal neuropil of the developing chick retina. Cell and Tissue Research. 286: 13-22. PMID 8781208 DOI: 10.1007/s004410050670  0.36
1996 So KL, Pun S, Wan DC, Tsim KW. Cerebellar granule cells express a specific isoform of agrin that lacks the acetylcholine receptor aggregating activity. Febs Letters. 379: 63-8. PMID 8566231 DOI: 10.1016/0014-5793(95)01486-1  0.36
1995 Pun S, Tsim KW. Truncated form of pro-acetylcholine receptor-inducing activity (ARIA) induces AChR alpha-subunit but not AChE transcripts in cultured chick myotubes. Neuroscience Letters. 198: 107-10. PMID 8592632 DOI: 10.1016/0304-3940(95)11974-2  0.36
1995 Ip FC, Fu AK, Tsim KW, Ip NY. Cloning of the alpha component of the chick ciliary neurotrophic factor receptor: developmental expression and down-regulation in denervated skeletal muscle. Journal of Neurochemistry. 65: 2393-400. PMID 7595532  0.36
1992 Tsim KW, Greenberg I, Rimer M, Randall WR, Salpeter MM. Transcripts for the acetylcholine receptor and acetylcholine esterase show distribution differences in cultured chick muscle cells. The Journal of Cell Biology. 118: 1201-12. PMID 1512293  0.36
1992 Ruegg MA, Tsim KW, Horton SE, Kröger S, Escher G, Gensch EM, McMahan UJ. The agrin gene codes for a family of basal lamina proteins that differ in function and distribution. Neuron. 8: 691-9. PMID 1314621 DOI: 10.1016/0896-6273(92)90090-Z  0.36
1992 Tsim KW, Ruegg MA, Escher G, Kröger S, McMahan UJ. cDNA that encodes active agrin. Neuron. 8: 677-89. PMID 1314620 DOI: 10.1016/0896-6273(92)90089-V  0.36
1988 Tsim KW, Randall WR, Barnard EA. An asymmetric form of muscle acetylcholinesterase contains three subunit types and two enzymic activities in one molecule. Proceedings of the National Academy of Sciences of the United States of America. 85: 1262-6. PMID 3422489  0.36
1988 Tsim KW, Randall WR, Barnard EA. Identification of a 17 S asymmetric butyrylcholinesterase in chick muscle by monoclonal antibodies. Neuroscience Letters. 86: 245-9. PMID 3368125 DOI: 10.1016/0304-3940(88)90579-4  0.36
1988 Tsim KW, Randall WR, Barnard EA. Monoclonal antibodies specific for the different subunits of asymmetric acetylcholinesterase from chick muscle. Journal of Neurochemistry. 51: 95-104. PMID 3288716  0.36
1988 Tsim KW, Randall WR, Barnard EA. Synaptic acetylcholinesterase of chicken muscle changes during development from a hybrid to a homogeneous enzyme. The Embo Journal. 7: 2451-6. PMID 3056716  0.36
1988 Weetman AP, Tse CK, Randall WR, Tsim KW, Barnard EA. Acetylcholinesterase antibodies and thyroid autoimmunity. Clinical and Experimental Immunology. 71: 96-9. PMID 2450705  0.36
1987 Randall WR, Tsim KW, Lai J, Barnard EA. Monoclonal antibodies against chicken brain acetylcholinesterase. Their use in immunopurification and immunochemistry to demonstrate allelic variants of the enzyme. European Journal of Biochemistry / Febs. 164: 95-102. PMID 3830186  0.36
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