Uwe Rudolph - Publications

Affiliations: 
McLean Hospital / Harvard Medical School, Belmont, MA, United States 
 McLean Hospital, Belmont, MA, United States 
Area:
GABA-A receptors, Schizophrenia
Website:
http://www.mcleanhospital.org/research-programs/uwe-rudolph-laboratory-genetic-neuropharmacology

163 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Rudolph U, Moss SJ. Modulating anxiety and activity. Science (New York, N.Y.). 366: 185-186. PMID 31601757 DOI: 10.1126/science.aaz3176  0.64
2019 Hofmann JI, Schwarz C, Rudolph U, Antkowiak B. Effects of Diazepam on Low-Frequency and High-Frequency Electrocortical γ-Power Mediated by α1- and α2-GABA Receptors. International Journal of Molecular Sciences. 20. PMID 31315211 DOI: 10.3390/ijms20143486  0.52
2019 Bodkin JA, Coleman MJ, Godfrey LJ, Carvalho CMB, Morgan CJ, Suckow RF, Anderson T, Ongur D, Kaufman MJ, Lewandowski KE, Siegel AJ, Waldstreicher E, Grochowski CM, Javitt DC, Rujescu D, ... ... Rudolph U, et al. Targeted Treatment of Individuals With Psychosis Carrying a Copy Number Variant Containing a Genomic Triplication of the Glycine Decarboxylase Gene. Biological Psychiatry. PMID 31279534 DOI: 10.1016/j.biopsych.2019.04.031  0.68
2018 Neumann E, Rudolph U, Knutson DE, Li G, Cook JM, Hentschke H, Antkowiak B, Drexler B. Zolpidem Activation of Alpha 1-Containing GABA Receptors Selectively Inhibits High Frequency Action Potential Firing of Cortical Neurons. Frontiers in Pharmacology. 9: 1523. PMID 30687091 DOI: 10.3389/fphar.2018.01523  0.52
2018 Neumann E, Ralvenius WT, Acuña MA, Rudolph U, Zeilhofer HU. TP003 is a non-selective benzodiazepine site agonist that induces anxiolysis via α2GABA receptors. Neuropharmacology. PMID 30240781 DOI: 10.1016/j.neuropharm.2018.09.026  0.36
2018 Ralvenius WT, Neumann E, Pagani M, Acuña MA, Wildner H, Benke D, Fischer N, Rostaher A, Schwager S, Detmar M, Frauenknecht K, Aguzzi A, Hubbs JL, Rudolph U, Favrot C, et al. Itch suppression in mice and dogs by modulation of spinal α2 and α3GABA receptors. Nature Communications. 9: 3230. PMID 30104684 DOI: 10.1038/s41467-018-05709-0  0.6
2018 Engin E, Benham RS, Rudolph U. An Emerging Circuit Pharmacology of GABA Receptors. Trends in Pharmacological Sciences. PMID 29903580 DOI: 10.1016/j.tips.2018.04.003  0.68
2018 Li S, Uno Y, Rudolph U, Cobb J, Liu J, Anderson T, Levy D, Balu DT, Coyle JT. Astrocytes in Primary Cultures Express Serine Racemase, Synthesize D-Serine and Acquire A1 Reactive Astrocyte Features. Biochemical Pharmacology. PMID 29305854 DOI: 10.1016/j.bcp.2017.12.023  0.48
2017 Benham RS, Hewage NB, Suckow RF, Engin E, Rudolph U. Corrigendum to "Prodepressant- and anxiogenic-like effects of serotonin-selective, but not noradrenaline-selective, antidepressant agents in mice lacking α2-containing GABAA receptors" [Behav. Brain Res. 332 (2017) 172-179]. Behavioural Brain Research. PMID 29070432 DOI: 10.1016/j.bbr.2017.10.006  0.68
2017 Balk M, Hentschke H, Rudolph U, Antkowiak B, Drexler B. Differential depression of neuronal network activity by midazolam and its main metabolite 1-hydroxymidazolam in cultured neocortical slices. Scientific Reports. 7: 3503. PMID 28615640 DOI: 10.1038/s41598-017-03154-5  0.52
2017 Benham RS, Hewage NB, Suckow RF, Engin E, Rudolph U. Prodepressant- and anxiogenic-like effects of serotonin-selective, but not noradrenaline-selective, antidepressant agents in mice lacking α2-containing GABAA receptors. Behavioural Brain Research. PMID 28587819 DOI: 10.1016/j.bbr.2017.05.063  0.68
2017 Möhler H, Rudolph U. Disinhibition, an emerging pharmacology of learning and memory. F1000research. 6. PMID 28232865 DOI: 10.12688/f1000research.9947.1  0.68
2016 Newman EL, Gunner G, Huynh P, Gachette D, Moss SJ, Smart TG, Rudolph U, DeBold JF, Miczek KA. Effects of Gabra2 Point Mutations on Alcohol Intake: Increased Binge-Like and Blunted Chronic Drinking by Mice. Alcoholism, Clinical and Experimental Research. PMID 27717041 DOI: 10.1111/acer.13215  0.64
2016 Ralvenius WT, Acuña MA, Benke D, Matthey A, Daali Y, Rudolph U, Desmeules J, Zeilhofer HU, Besson M. The clobazam metabolite N-desmethyl clobazam is an α2 preferring benzodiazepine with an improved therapeutic window for antihyperalgesia. Neuropharmacology. PMID 27392635 DOI: 10.1016/j.neuropharm.2016.07.004  0.6
2016 Deprez F, Vogt F, Floriou-Servou A, Lafourcade C, Rudolph U, Tyagarajan SK, Fritschy JM. Partial inactivation of GABAA receptors containing the α5 subunit affects the development of adult-born dentate gyrus granule cells. The European Journal of Neuroscience. PMID 27364953 DOI: 10.1111/ejn.13329  0.64
2016 Antkowiak B, Rudolph U. New insights in the systemic and molecular underpinnings of general anesthetic actions mediated by γ-aminobutyric acid A receptors. Current Opinion in Anaesthesiology. PMID 27168087 DOI: 10.1097/ACO.0000000000000358  0.52
2016 Behlke LM, Foster RA, Liu J, Benke D, Benham RS, Nathanson A, Yee BK, Zeilhofer HU, Engin E, Rudolph U. A Pharmaco-Genetic 'Restriction-of-Function' Approach Reveals Evidence for Anxiolytic-Like Actions Mediated by α5-Containing GABAA Receptors in Mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27067130 DOI: 10.1038/npp.2016.49  0.64
2016 Engin E, Smith KS, Gao Y, Nagy D, Foster RA, Tsvetkov E, Keist R, Crestani F, Fritschy JM, Bolshakov VY, Hajos M, Heldt SA, Rudolph U. Modulation of anxiety and fear via distinct intrahippocampal circuits. Elife. 5. PMID 26971710 DOI: 10.7554/eLife.14120  0.68
2015 Vien TN, Modgil A, Abramian AM, Jurd R, Walker J, Brandon NJ, Terunuma M, Rudolph U, Maguire J, Davies PA, Moss SJ. Compromising the phosphodependent regulation of the GABAAR β3 subunit reproduces the core phenotypes of autism spectrum disorders. Proceedings of the National Academy of Sciences of the United States of America. 112: 14805-10. PMID 26627235 DOI: 10.1073/pnas.1514657112  0.64
2015 Engin E, Zarnowska ED, Benke D, Tsvetkov E, Sigal M, Keist R, Bolshakov VY, Pearce RA, Rudolph U. Tonic Inhibitory Control of Dentate Gyrus Granule Cells by α5-Containing GABAA Receptors Reduces Memory Interference. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 13698-712. PMID 26446222 DOI: 10.1523/JNEUROSCI.1370-15.2015  0.64
2015 Newman EL, Smith KS, Takahashi A, Chu A, Hwa LS, Chen Y, DeBold JF, Rudolph U, Miczek KA. α2-containing GABA(A) receptors: a requirement for midazolam-escalated aggression and social approach in mice. Psychopharmacology. PMID 26381154 DOI: 10.1007/s00213-015-4069-9  0.64
2015 Rodgers FC, Zarnowska ED, Laha KT, Engin E, Zeller A, Keist R, Rudolph U, Pearce RA. Etomidate Impairs Long-Term Potentiation In Vitro by Targeting α5-Subunit Containing GABAA Receptors on Nonpyramidal Cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 9707-16. PMID 26134653 DOI: 10.1523/JNEUROSCI.0315-15.2015  0.64
2015 Ralvenius WT, Benke D, Acuña MA, Rudolph U, Zeilhofer HU. Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABAA receptor subtype. Nature Communications. 6: 6803. PMID 25865415 DOI: 10.1038/ncomms7803  0.64
2015 Zarnowska ED, Rodgers FC, Oh I, Rau V, Lor C, Laha KT, Jurd R, Rudolph U, Eger EI, Pearce RA. Etomidate blocks LTP and impairs learning but does not enhance tonic inhibition in mice carrying the N265M point mutation in the beta3 subunit of the GABA(A) receptor. Neuropharmacology. 93: 171-8. PMID 25680234 DOI: 10.1016/j.neuropharm.2015.01.011  0.64
2015 Rudolph U, Enna SJ. Preface: A tribute to professor Hanns Möhler. Advances in Pharmacology (San Diego, Calif.). 73: ix-xii. PMID 25637444 DOI: 10.1016/S1054-3589(15)00022-8  0.64
2015 Rudolph U, Enna SJ. Preface: a tribute to professor Hanns Möhler. Advances in Pharmacology (San Diego, Calif.). 72: ix-xii. PMID 25600374 DOI: 10.1016/S1054-3589(15)00008-3  0.64
2015 Crestani F, Rudolph U. Behavioral functions of GABAA receptor subtypes--the Zurich experience. Advances in Pharmacology (San Diego, Calif.). 72: 37-51. PMID 25600366 DOI: 10.1016/bs.apha.2014.10.001  0.64
2015 Eckle VS, Rudolph U, Antkowiak B, Grasshoff C. Propofol modulates phasic and tonic GABAergic currents in spinal ventral horn interneurones. British Journal of Anaesthesia. 114: 491-8. PMID 25150989 DOI: 10.1093/bja/aeu269  0.64
2014 Labrakakis C, Rudolph U, De Koninck Y. The heterogeneity in GABAA receptor-mediated IPSC kinetics reflects heterogeneity of subunit composition among inhibitory and excitatory interneurons in spinal lamina II. Frontiers in Cellular Neuroscience. 8: 424. PMID 25565959 DOI: 10.3389/fncel.2014.00424  0.64
2014 Martin CB, Gassmann M, Chevarin C, Hamon M, Rudolph U, Bettler B, Lanfumey L, Mongeau R. Effect of genetic and pharmacological blockade of GABA receptors on the 5-HT2C receptor function during stress. Journal of Neurochemistry. 131: 566-72. PMID 25113583 DOI: 10.1111/jnc.12929  0.64
2014 Seifi M, Brown JF, Mills J, Bhandari P, Belelli D, Lambert JJ, Rudolph U, Swinny JD. Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 10361-78. PMID 25080596 DOI: 10.1523/JNEUROSCI.0441-14.2014  0.64
2014 Corteen NL, Carter JA, Rudolph U, Belelli D, Lambert JJ, Swinny JD. Localisation and stress-induced plasticity of GABAA receptor subunits within the cellular networks of the mouse dorsal raphe nucleus. Brain Structure & Function. PMID 24973971 DOI: 10.1007/s00429-014-0824-7  0.64
2014 Riccio A, Li Y, Tsvetkov E, Gapon S, Yao GL, Smith KS, Engin E, Rudolph U, Bolshakov VY, Clapham DE. Decreased anxiety-like behavior and Gαq/11-dependent responses in the amygdala of mice lacking TRPC4 channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 3653-67. PMID 24599464 DOI: 10.1523/JNEUROSCI.2274-13.2014  0.64
2014 Engin E, Bakhurin KI, Smith KS, Hines RM, Reynolds LM, Tang W, Sprengel R, Moss SJ, Rudolph U. Neural basis of benzodiazepine reward: requirement for α2 containing GABAA receptors in the nucleus accumbens. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 1805-15. PMID 24553732 DOI: 10.1038/npp.2014.41  0.64
2014 Benham RS, Engin E, Rudolph U. Diversity of neuronal inhibition: a path to novel treatments for neuropsychiatric disorders. Jama Psychiatry. 71: 91-3. PMID 24196284 DOI: 10.1001/jamapsychiatry.2013.3059  0.64
2014 Rudolph U, Möhler H. GABAA receptor subtypes: Therapeutic potential in Down syndrome, affective disorders, schizophrenia, and autism. Annual Review of Pharmacology and Toxicology. 54: 483-507. PMID 24160694 DOI: 10.1146/annurev-pharmtox-011613-135947  0.64
2014 Paul J, Yévenes GE, Benke D, Di Lio A, Ralvenius WT, Witschi R, Scheurer L, Cook JM, Rudolph U, Fritschy JM, Zeilhofer HU. Antihyperalgesia by α2-GABAA receptors occurs via a genuine spinal action and does not involve supraspinal sites. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 477-87. PMID 24045508 DOI: 10.1038/npp.2013.221  0.64
2013 Licata SC, Shinday NM, Huizenga MN, Darnell SB, Sangrey GR, Rudolph U, Rowlett JK, Sadri-Vakili G. Alterations in brain-derived neurotrophic factor in the mouse hippocampus following acute but not repeated benzodiazepine treatment. Plos One. 8: e84806. PMID 24367698 DOI: 10.1371/journal.pone.0084806  0.64
2013 Christian CA, Herbert AG, Holt RL, Peng K, Sherwood KD, Pangratz-Fuehrer S, Rudolph U, Huguenard JR. Endogenous positive allosteric modulation of GABA(A) receptors by diazepam binding inhibitor. Neuron. 78: 1063-74. PMID 23727119 DOI: 10.1016/j.neuron.2013.04.026  0.64
2013 Van't Veer A, Bechtholt AJ, Onvani S, Potter D, Wang Y, Liu-Chen LY, Schütz G, Chartoff EH, Rudolph U, Cohen BM, Carlezon WA. Ablation of kappa-opioid receptors from brain dopamine neurons has anxiolytic-like effects and enhances cocaine-induced plasticity. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 1585-97. PMID 23446450 DOI: 10.1038/npp.2013.58  0.64
2013 Drexler B, Zinser S, Huang S, Poe MM, Rudolph U, Cook JM, Antkowiak B. Enhancing the function of alpha5-subunit-containing GABAA receptors promotes action potential firing of neocortical neurons during up-states. European Journal of Pharmacology. 703: 18-24. PMID 23380687 DOI: 10.1016/j.ejphar.2013.01.034  0.64
2013 Ohtsuka N, Badurek S, Busslinger M, Benes FM, Minichiello L, Rudolph U. GABAergic neurons regulate lateral ventricular development via transcription factor Pax5. Genesis (New York, N.Y. : 2000). 51: 234-45. PMID 23349049 DOI: 10.1002/dvg.22370  0.64
2013 Straub CJ, Lau HM, Parlato R, Schuetz G, Fritschy JM, Rudolph U. Bidirectional regulation of intravenous general anesthetic actions by α3-containing γ-aminobutyric acid A receptors. Anesthesiology. 118: 562-76. PMID 23303487 DOI: 10.1097/ALN.0b013e3182800d76  0.64
2013 Blednov YA, Benavidez JM, Black M, Chandra D, Homanics GE, Rudolph U, Harris RA. Linking GABA(A) receptor subunits to alcohol-induced conditioned taste aversion and recovery from acute alcohol intoxication. Neuropharmacology. 67: 46-56. PMID 23147414 DOI: 10.1016/j.neuropharm.2012.10.016  0.64
2013 Koester C, Rudolph U, Haenggi T, Papilloud A, Fritschy JM, Crestani F. Dissecting the role of diazepam-sensitive γ-aminobutyric acid type A receptors in defensive behavioral reactivity to mild threat. Pharmacology, Biochemistry, and Behavior. 103: 541-9. PMID 23067879 DOI: 10.1016/j.pbb.2012.10.004  0.64
2012 Engin E, Liu J, Rudolph U. α2-containing GABA(A) receptors: a target for the development of novel treatment strategies for CNS disorders. Pharmacology & Therapeutics. 136: 142-52. PMID 22921455 DOI: 10.1016/j.pharmthera.2012.08.006  0.64
2012 Reynolds LM, Engin E, Tantillo G, Lau HM, Muschamp JW, Carlezon WA, Rudolph U. Differential roles of GABA(A) receptor subtypes in benzodiazepine-induced enhancement of brain-stimulation reward. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 2531-40. PMID 22763624 DOI: 10.1038/npp.2012.115  0.64
2012 Pallotto M, Nissant A, Fritschy JM, Rudolph U, Sassoè-Pognetto M, Panzanelli P, Lledo PM. Early formation of GABAergic synapses governs the development of adult-born neurons in the olfactory bulb. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 9103-15. PMID 22745509 DOI: 10.1523/JNEUROSCI.0214-12.2012  0.64
2012 Marowsky A, Rudolph U, Fritschy JM, Arand M. Tonic inhibition in principal cells of the amygdala: a central role for α3 subunit-containing GABAA receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 8611-9. PMID 22723702 DOI: 10.1523/JNEUROSCI.4404-11.2012  0.64
2012 Auferkorte ON, Baden T, Kaushalya SK, Zabouri N, Rudolph U, Haverkamp S, Euler T. GABA(A) receptors containing the α2 subunit are critical for direction-selective inhibition in the retina. Plos One. 7: e35109. PMID 22506070 DOI: 10.1371/journal.pone.0035109  0.64
2012 Smith KS, Engin E, Meloni EG, Rudolph U. Benzodiazepine-induced anxiolysis and reduction of conditioned fear are mediated by distinct GABAA receptor subtypes in mice. Neuropharmacology. 63: 250-8. PMID 22465203 DOI: 10.1016/j.neuropharm.2012.03.001  0.64
2012 Smith KS, Rudolph U. Anxiety and depression: mouse genetics and pharmacological approaches to the role of GABA(A) receptor subtypes. Neuropharmacology. 62: 54-62. PMID 21810433 DOI: 10.1016/j.neuropharm.2011.07.026  0.64
2012 Yanovsky Y, Schubring S, Fleischer W, Gisselmann G, Zhu XR, Lübbert H, Hatt H, Rudolph U, Haas HL, Sergeeva OA. GABAA receptors involved in sleep and anaesthesia: β1- versus β3-containing assemblies. PflüGers Archiv : European Journal of Physiology. 463: 187-99. PMID 21735059 DOI: 10.1007/s00424-011-0988-4  0.64
2011 Lalive AL, Rudolph U, Lüscher C, Tan KR. Is there a way to curb benzodiazepine addiction? Swiss Medical Weekly. 141: w13277. PMID 22012428 DOI: 10.4414/smw.2011.13277  0.64
2011 Panzanelli P, Gunn BG, Schlatter MC, Benke D, Tyagarajan SK, Scheiffele P, Belelli D, Lambert JJ, Rudolph U, Fritschy JM. Distinct mechanisms regulate GABAA receptor and gephyrin clustering at perisomatic and axo-axonic synapses on CA1 pyramidal cells. The Journal of Physiology. 589: 4959-80. PMID 21825022 DOI: 10.1113/jphysiol.2011.216028  0.64
2011 Rudolph U, Knoflach F. Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes. Nature Reviews. Drug Discovery. 10: 685-97. PMID 21799515 DOI: 10.1038/nrd3502  0.64
2011 Bähner F, Weiss EK, Birke G, Maier N, Schmitz D, Rudolph U, Frotscher M, Traub RD, Both M, Draguhn A. Cellular correlate of assembly formation in oscillating hippocampal networks in vitro. Proceedings of the National Academy of Sciences of the United States of America. 108: E607-16. PMID 21768381 DOI: 10.1073/pnas.1103546108  0.64
2011 Duveau V, Laustela S, Barth L, Gianolini F, Vogt KE, Keist R, Chandra D, Homanics GE, Rudolph U, Fritschy JM. Spatiotemporal specificity of GABAA receptor-mediated regulation of adult hippocampal neurogenesis. The European Journal of Neuroscience. 34: 362-73. PMID 21722213 DOI: 10.1111/j.1460-9568.2011.07782.x  0.64
2011 Witschi R, Punnakkal P, Paul J, Walczak JS, Cervero F, Fritschy JM, Kuner R, Keist R, Rudolph U, Zeilhofer HU. Presynaptic alpha2-GABAA receptors in primary afferent depolarization and spinal pain control. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 8134-42. PMID 21632935 DOI: 10.1523/JNEUROSCI.6328-10.2011  0.64
2011 Tan KR, Rudolph U, Lüscher C. Hooked on benzodiazepines: GABAA receptor subtypes and addiction. Trends in Neurosciences. 34: 188-97. PMID 21353710 DOI: 10.1016/j.tins.2011.01.004  0.64
2011 Drexler B, Antkowiak B, Engin E, Rudolph U. Identification and characterization of anesthetic targets by mouse molecular genetics approaches. Canadian Journal of Anaesthesia = Journal Canadien D'AnesthéSie. 58: 178-90. PMID 21174184 DOI: 10.1007/s12630-010-9414-1  0.64
2011 Vollenweider I, Smith KS, Keist R, Rudolph U. Antidepressant-like properties of α2-containing GABA(A) receptors. Behavioural Brain Research. 217: 77-80. PMID 20965216 DOI: 10.1016/j.bbr.2010.10.009  0.64
2011 Smith KS, Meloni EG, Myers KM, Van't Veer A, Carlezon WA, Rudolph U. Reduction of fear-potentiated startle by benzodiazepines in C57BL/6J mice. Psychopharmacology. 213: 697-706. PMID 20922362 DOI: 10.1007/s00213-010-2026-1  0.64
2011 Rudolph U. Gi3 g protein Xpharm: the Comprehensive Pharmacology Reference. 1-3. DOI: 10.1016/B978-008055232-3.60587-2  0.68
2011 Rudolph U. Gi2 g protein Xpharm: the Comprehensive Pharmacology Reference. 1-4. DOI: 10.1016/B978-008055232-3.60586-0  0.68
2011 Rudolph U. Gi1 g protein Xpharm: the Comprehensive Pharmacology Reference. 1-3. DOI: 10.1016/B978-008055232-3.60585-9  0.68
2011 Rudolph U. Gi-o heterotrimeric g protein gtpases Xpharm: the Comprehensive Pharmacology Reference. 1-3. DOI: 10.1016/B978-008055232-3.60584-7  0.68
2011 Rudolph U. Heterotrimeric g protein gtpases Xpharm: the Comprehensive Pharmacology Reference. 1-4. DOI: 10.1016/B978-008055232-3.60573-2  0.68
2010 Butovas S, Rudolph U, Jurd R, Schwarz C, Antkowiak B. Activity patterns in the prefrontal cortex and hippocampus during and after awakening from etomidate anesthesia. Anesthesiology. 113: 48-57. PMID 20508498 DOI: 10.1097/ALN.0b013e3181dc1db7  0.64
2010 Tan KR, Brown M, Labouèbe G, Yvon C, Creton C, Fritschy JM, Rudolph U, Lüscher C. Neural bases for addictive properties of benzodiazepines. Nature. 463: 769-74. PMID 20148031 DOI: 10.1038/nature08758  0.64
2010 Straub CJ, Carlezon WA, Rudolph U. Diazepam and cocaine potentiate brain stimulation reward in C57BL/6J mice. Behavioural Brain Research. 206: 17-20. PMID 19716385 DOI: 10.1016/j.bbr.2009.08.025  0.64
2009 Li P, Rudolph U, Huntsman MM. Long-term sensory deprivation selectively rearranges functional inhibitory circuits in mouse barrel cortex. Proceedings of the National Academy of Sciences of the United States of America. 106: 12156-61. PMID 19584253 DOI: 10.1073/pnas.0900922106  0.64
2009 Drexler B, Jurd R, Rudolph U, Antkowiak B. Distinct actions of etomidate and propofol at beta3-containing gamma-aminobutyric acid type A receptors. Neuropharmacology. 57: 446-55. PMID 19555700 DOI: 10.1016/j.neuropharm.2009.06.014  0.64
2009 Balic E, Rudolph U, Fritschy JM, Mohler H, Benke D. The alpha5(H105R) mutation impairs alpha5 selective binding properties by altered positioning of the alpha5 subunit in GABAA receptors containing two distinct types of alpha subunits. Journal of Neurochemistry. 110: 244-54. PMID 19457072 DOI: 10.1111/j.1471-4159.2009.06119.x  0.64
2009 Riccio A, Li Y, Moon J, Kim KS, Smith KS, Rudolph U, Gapon S, Yao GL, Tsvetkov E, Rodig SJ, Van't Veer A, Meloni EG, Carlezon WA, Bolshakov VY, Clapham DE. Essential role for TRPC5 in amygdala function and fear-related behavior. Cell. 137: 761-72. PMID 19450521 DOI: 10.1016/j.cell.2009.03.039  0.64
2009 Schofield CM, Kleiman-Weiner M, Rudolph U, Huguenard JR. A gain in GABAA receptor synaptic strength in thalamus reduces oscillatory activity and absence seizures. Proceedings of the National Academy of Sciences of the United States of America. 106: 7630-5. PMID 19380748 DOI: 10.1073/pnas.0811326106  0.64
2009 Zecharia AY, Nelson LE, Gent TC, Schumacher M, Jurd R, Rudolph U, Brickley SG, Maze M, Franks NP. The involvement of hypothalamic sleep pathways in general anesthesia: testing the hypothesis using the GABAA receptor beta3N265M knock-in mouse. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 2177-87. PMID 19228970 DOI: 10.1523/JNEUROSCI.4997-08.2009  0.64
2009 Knabl J, Zeilhofer UB, Crestani F, Rudolph U, Zeilhofer HU. Genuine antihyperalgesia by systemic diazepam revealed by experiments in GABAA receptor point-mutated mice. Pain. 141: 233-8. PMID 19091469 DOI: 10.1016/j.pain.2008.10.015  0.64
2009 Zarnowska ED, Keist R, Rudolph U, Pearce RA. GABAA receptor alpha5 subunits contribute to GABAA,slow synaptic inhibition in mouse hippocampus. Journal of Neurophysiology. 101: 1179-91. PMID 19073796 DOI: 10.1152/jn.91203.2008  0.64
2009 Benke D, Barberis A, Kopp S, Altmann KH, Schubiger M, Vogt KE, Rudolph U, Möhler H. GABA A receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts. Neuropharmacology. 56: 174-81. PMID 18602406 DOI: 10.1016/j.neuropharm.2008.06.013  0.64
2008 Fiorelli R, Rudolph U, Straub CJ, Feldon J, Yee BK. Affective and cognitive effects of global deletion of alpha3-containing gamma-aminobutyric acid-A receptors. Behavioural Pharmacology. 19: 582-96. PMID 18690113 DOI: 10.1097/FBP.0b013e32830dc0c7  0.64
2008 Winsky-Sommerer R, Knapman A, Fedele DE, Schofield CM, Vyazovskiy VV, Rudolph U, Huguenard JR, Fritschy JM, Tobler I. Normal sleep homeostasis and lack of epilepsy phenotype in GABA A receptor alpha3 subunit-knockout mice. Neuroscience. 154: 595-605. PMID 18485607 DOI: 10.1016/j.neuroscience.2008.03.081  0.64
2008 Möhler H, Rudolph U, Boison D, Singer P, Feldon J, Yee BK. Regulation of cognition and symptoms of psychosis: focus on GABA(A) receptors and glycine transporter 1. Pharmacology, Biochemistry, and Behavior. 90: 58-64. PMID 18455219 DOI: 10.1016/j.pbb.2008.03.003  0.64
2008 Knabl J, Witschi R, Hösl K, Reinold H, Zeilhofer UB, Ahmadi S, Brockhaus J, Sergejeva M, Hess A, Brune K, Fritschy JM, Rudolph U, Möhler H, Zeilhofer HU. Reversal of pathological pain through specific spinal GABAA receptor subtypes. Nature. 451: 330-4. PMID 18202657 DOI: 10.1038/nature06493  0.64
2008 Zeller A, Jurd R, Lambert S, Arras M, Drexler B, Grashoff C, Antkowiak B, Rudolph U. Inhibitory ligand-gated ion channels as substrates for general anesthetic actions. Handbook of Experimental Pharmacology. 31-51. PMID 18175085 DOI: 10.1007/978-3-540-74806-9_2  0.64
2008 Zeller A, Crestani F, Camenisch I, Iwasato T, Itohara S, Fritschy JM, Rudolph U. Cortical glutamatergic neurons mediate the motor sedative action of diazepam. Molecular Pharmacology. 73: 282-91. PMID 17965197 DOI: 10.1124/mol.107.038828  0.64
2008 Gerdjikov TV, Rudolph U, Keist R, Möhler H, Feldon J, Yee BK. Hippocampal alpha 5 subunit-containing GABA A receptors are involved in the development of the latent inhibition effect. Neurobiology of Learning and Memory. 89: 87-94. PMID 17638582 DOI: 10.1016/j.nlm.2007.06.003  0.64
2007 Grasshoff C, Jurd R, Rudolph U, Antkowiak B. Modulation of presynaptic beta3-containing GABAA receptors limits the immobilizing actions of GABAergic anesthetics. Molecular Pharmacology. 72: 780-7. PMID 17584992 DOI: 10.1124/mol.107.037648  0.64
2007 Sanchis-Segura C, Cline B, Jurd R, Rudolph U, Spanagel R. Etomidate and propofol-hyposensitive GABAA receptor beta3(N265M) mice show little changes in acute alcohol sensitivity but enhanced tolerance and withdrawal. Neuroscience Letters. 416: 275-8. PMID 17350761 DOI: 10.1016/j.neulet.2007.02.024  0.64
2007 Zeller A, Arras M, Jurd R, Rudolph U. Mapping the contribution of beta3-containing GABAA receptors to volatile and intravenous general anesthetic actions. Bmc Pharmacology. 7: 2. PMID 17319964 DOI: 10.1186/1471-2210-7-2  0.64
2007 Pangratz-Fuehrer S, Rudolph U, Huguenard JR. Giant spontaneous depolarizing potentials in the developing thalamic reticular nucleus. Journal of Neurophysiology. 97: 2364-72. PMID 17251370 DOI: 10.1152/jn.00646.2006  0.64
2007 Zeller A, Arras M, Jurd R, Rudolph U. Identification of a molecular target mediating the general anesthetic actions of pentobarbital. Molecular Pharmacology. 71: 852-9. PMID 17164405 DOI: 10.1124/mol.106.030049  0.64
2006 Grasshoff C, Drexler B, Rudolph U, Antkowiak B. Anaesthetic drugs: linking molecular actions to clinical effects. Current Pharmaceutical Design. 12: 3665-79. PMID 17073666 DOI: 10.2174/138161206778522038  0.64
2006 Studer R, von Boehmer L, Haenggi T, Schweizer C, Benke D, Rudolph U, Fritschy JM. Alteration of GABAergic synapses and gephyrin clusters in the thalamic reticular nucleus of GABAA receptor alpha3 subunit-null mice. The European Journal of Neuroscience. 24: 1307-15. PMID 16987218 DOI: 10.1111/j.1460-9568.2006.05006.x  0.64
2006 Drexler B, Jurd R, Rudolph U, Antkowiak B. Dual actions of enflurane on postsynaptic currents abolished by the gamma-aminobutyric acid type A receptor beta3(N265M) point mutation. Anesthesiology. 105: 297-304. PMID 16871063 DOI: 10.1097/00000542-200608000-00012  0.64
2006 Merrill AW, Barter LS, Rudolph U, Eger EI, Antognini JF, Carstens MI, Carstens E. Propofol's effects on nociceptive behavior and spinal c-fos expression after intraplantar formalin injection in mice with a mutation in the gamma-aminobutyric acid-type(A) receptor beta3 subunit. Anesthesia and Analgesia. 103: 478-83, table of con. PMID 16861438 DOI: 10.1213/01.ane.0000223847.50233.1b  0.64
2006 Prenosil GA, Schneider Gasser EM, Rudolph U, Keist R, Fritschy JM, Vogt KE. Specific subtypes of GABAA receptors mediate phasic and tonic forms of inhibition in hippocampal pyramidal neurons. Journal of Neurophysiology. 96: 846-57. PMID 16835366 DOI: 10.1152/jn.01199.2006  0.64
2006 Sohal VS, Pangratz-Fuehrer S, Rudolph U, Huguenard JR. Intrinsic and synaptic dynamics interact to generate emergent patterns of rhythmic bursting in thalamocortical neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 4247-55. PMID 16624945 DOI: 10.1523/JNEUROSCI.3812-05.2006  0.64
2006 Rudolph U, Möhler H. GABA-based therapeutic approaches: GABAA receptor subtype functions. Current Opinion in Pharmacology. 6: 18-23. PMID 16376150 DOI: 10.1016/j.coph.2005.10.003  0.64
2006 Drexler B, Grasshoff C, Rudolph U, Unertl K, Antkowiak B. [The GABA(A) receptor family: possibilities for the development of better anesthetics]. Der Anaesthesist. 55: 287-95. PMID 16315024 DOI: 10.1007/s00101-005-0950-y  0.68
2005 Möhler H, Fritschy JM, Vogt K, Crestani F, Rudolph U. Pathophysiology and pharmacology of GABA(A) receptors. Handbook of Experimental Pharmacology. 225-47. PMID 16594261 DOI: 10.1007/3-540-28082-0-9  0.68
2005 Grasshoff C, Rudolph U, Antkowiak B. Molecular and systemic mechanisms of general anaesthesia: the 'multi-site and multiple mechanisms' concept. Current Opinion in Anaesthesiology. 18: 386-91. PMID 16534263 DOI: 10.1097/01.aco.0000174961.90135.dc  0.64
2005 Yee BK, Keist R, von Boehmer L, Studer R, Benke D, Hagenbuch N, Dong Y, Malenka RC, Fritschy JM, Bluethmann H, Feldon J, Möhler H, Rudolph U. A schizophrenia-related sensorimotor deficit links alpha 3-containing GABAA receptors to a dopamine hyperfunction. Proceedings of the National Academy of Sciences of the United States of America. 102: 17154-9. PMID 16284244 DOI: 10.1073/pnas.0508752102  0.68
2005 Zeller A, Arras M, Lazaris A, Jurd R, Rudolph U. Distinct molecular targets for the central respiratory and cardiac actions of the general anesthetics etomidate and propofol. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 1677-9. PMID 16046472 DOI: 10.1096/fj.04-3443fje  0.64
2005 Liao M, Sonner JM, Jurd R, Rudolph U, Borghese CM, Harris RA, Laster MJ, Eger EI. Beta3-containing gamma-aminobutyric acidA receptors are not major targets for the amnesic and immobilizing actions of isoflurane. Anesthesia and Analgesia. 101: 412-8, table of cont. PMID 16037154 DOI: 10.1213/01.ANE.0000154196.86587.35  0.64
2005 Liao M, Sonner JM, Husain SS, Miller KW, Jurd R, Rudolph U, Eger EI. R (+) etomidate and the photoactivable R (+) azietomidate have comparable anesthetic activity in wild-type mice and comparably decreased activity in mice with a N265M point mutation in the gamma-aminobutyric acid receptor beta3 subunit. Anesthesia and Analgesia. 101: 131-5, table of cont. PMID 15976219 DOI: 10.1213/01.ANE.0000153011.64764.6F  0.64
2005 Lambert S, Arras M, Vogt KE, Rudolph U. Isoflurane-induced surgical tolerance mediated only in part by beta3-containing GABA(A) receptors. European Journal of Pharmacology. 516: 23-7. PMID 15913600 DOI: 10.1016/j.ejphar.2005.04.030  0.64
2005 Drexler B, Roether CL, Jurd R, Rudolph U, Antkowiak B. Opposing actions of etomidate on cortical theta oscillations are mediated by different gamma-aminobutyric acid type A receptor subtypes. Anesthesiology. 102: 346-52. PMID 15681950 DOI: 10.1097/00000542-200502000-00017  0.64
2005 Hauser J, Rudolph U, Keist R, Möhler H, Feldon J, Yee BK. Hippocampal alpha5 subunit-containing GABAA receptors modulate the expression of prepulse inhibition. Molecular Psychiatry. 10: 201-7. PMID 15263904 DOI: 10.1038/sj.mp.4001554  0.68
2005 Zeller A, Arras M, Jurd R, Rudolph U. Distinct molecular targets for the central respiratory and cardiac actions of etomidate and propofol International Congress Series. 1283: 253-255. DOI: 10.1016/j.ics.2005.07.100  0.64
2005 Jurd R, Arras M, Zeller A, Lambert S, Lazaris A, Crestani F, Drexler B, Siegwart R, Vogt KE, Antkowiak B, Rudolph U. β3-containing GABAA receptors mediate the immobilizing and, in part, the hypnotic actions of etomidate and propofol International Congress Series. 1283: 143-148. DOI: 10.1016/j.ics.2005.07.076  0.68
2004 Möhler H, Fritschy JM, Crestani F, Hensch T, Rudolph U. Specific GABA(A) circuits in brain development and therapy. Biochemical Pharmacology. 68: 1685-90. PMID 15451412 DOI: 10.1016/j.bcp.2004.07.025  0.64
2004 Yee BK, Hauser J, Dolgov VV, Keist R, Möhler H, Rudolph U, Feldon J. GABA receptors containing the alpha5 subunit mediate the trace effect in aversive and appetitive conditioning and extinction of conditioned fear. The European Journal of Neuroscience. 20: 1928-36. PMID 15380015 DOI: 10.1111/j.1460-9568.2004.03642.x  0.64
2004 Kopp C, Rudolph U, Tobler I. Sleep EEG changes after zolpidem in mice. Neuroreport. 15: 2299-302. PMID 15371753 DOI: 10.1097/00001756-200410050-00031  0.64
2004 Rudolph U, Antkowiak B. Molecular and neuronal substrates for general anaesthetics. Nature Reviews. Neuroscience. 5: 709-20. PMID 15322529 DOI: 10.1038/nrn1496  0.64
2004 Benke D, Fakitsas P, Roggenmoser C, Michel C, Rudolph U, Mohler H. Analysis of the presence and abundance of GABAA receptors containing two different types of alpha subunits in murine brain using point-mutated alpha subunits. The Journal of Biological Chemistry. 279: 43654-60. PMID 15304513 DOI: 10.1074/jbc.M407154200  0.64
2004 van Rijnsoever C, Täuber M, Choulli MK, Keist R, Rudolph U, Mohler H, Fritschy JM, Crestani F. Requirement of alpha5-GABAA receptors for the development of tolerance to the sedative action of diazepam in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 6785-90. PMID 15282283 DOI: 10.1523/JNEUROSCI.1067-04.2004  0.64
2004 Fagiolini M, Fritschy JM, Löw K, Möhler H, Rudolph U, Hensch TK. Specific GABAA circuits for visual cortical plasticity. Science (New York, N.Y.). 303: 1681-3. PMID 15017002 DOI: 10.1126/science.1091032  0.64
2004 Huopaniemi L, Keist R, Randolph A, Certa U, Rudolph U. Diazepam-induced adaptive plasticity revealed by alpha1 GABAA receptor-specific expression profiling. Journal of Neurochemistry. 88: 1059-67. PMID 15009662 DOI: 10.1046/j.1471-4159.2003.02216.x  0.64
2004 Kopp C, Rudolph U, Löw K, Tobler I. Modulation of rhythmic brain activity by diazepam: GABA(A) receptor subtype and state specificity. Proceedings of the National Academy of Sciences of the United States of America. 101: 3674-9. PMID 14990800 DOI: 10.1073/pnas.0306975101  0.64
2004 Rudolph U, Möhler H. Analysis of GABAA receptor function and dissection of the pharmacology of benzodiazepines and general anesthetics through mouse genetics. Annual Review of Pharmacology and Toxicology. 44: 475-98. PMID 14744255 DOI: 10.1146/annurev.pharmtox.44.101802.121429  0.64
2004 Kosel M, Rudolph U, Wielepp P, Luginbühl M, Schmitt W, Fisch HU, Schlaepfer TE. Diminished GABA(A) receptor-binding capacity and a DNA base substitution in a patient with treatment-resistant depression and anxiety. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 347-50. PMID 14628001 DOI: 10.1038/sj.npp.1300353  0.64
2004 Möhler H, Rudolph U. Selective GABAA circuits for novel CNS drugs Drug Discovery Today: Therapeutic Strategies. 1: 117-123. DOI: 10.1016/j.ddstr.2004.08.019  0.68
2003 Täuber M, Calame-Droz E, Prut L, Rudolph U, Crestani F. alpha2-gamma-Aminobutyric acid (GABA)A receptors are the molecular substrates mediating precipitation of narcosis but not of sedation by the combined use of diazepam and alcohol in vivo. The European Journal of Neuroscience. 18: 2599-604. PMID 14622161  0.36
2003 Siegwart R, Krähenbühl K, Lambert S, Rudolph U. Mutational analysis of molecular requirements for the actions of general anaesthetics at the gamma-aminobutyric acidA receptor subtype, alpha1beta2gamma2. Bmc Pharmacology. 3: 13. PMID 14613517 DOI: 10.1186/1471-2210-3-13  0.64
2003 Bacci A, Rudolph U, Huguenard JR, Prince DA. Major differences in inhibitory synaptic transmission onto two neocortical interneuron subclasses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 9664-74. PMID 14573546  0.64
2003 Wieser HG, Rudolph U, Blau N, Boison D, Imhof HG, Bernays R, Yonekawa Y. Amino acid composition of brain cysts: levels of excitatory amino acids in cyst fluid fail to predict seizures. Epilepsy Research. 55: 191-9. PMID 12972173 DOI: 10.1016/S0920-1211(03)00106-2  0.64
2003 Kopp C, Rudolph U, Keist R, Tobler I. Diazepam-induced changes on sleep and the EEG spectrum in mice: role of the alpha3-GABA(A) receptor subtype. The European Journal of Neuroscience. 17: 2226-30. PMID 12786990 DOI: 10.1046/j.1460-9568.2003.02651.x  0.64
2003 Sohal VS, Keist R, Rudolph U, Huguenard JR. Dynamic GABA(A) receptor subtype-specific modulation of the synchrony and duration of thalamic oscillations. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 3649-57. PMID 12736336  0.64
2003 Jurd R, Arras M, Lambert S, Drexler B, Siegwart R, Crestani F, Zaugg M, Vogt KE, Ledermann B, Antkowiak B, Rudolph U. General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunit. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 250-2. PMID 12475885 DOI: 10.1096/fj.02-0611fje  0.64
2003 Täuber M, Calame-Droz E, Prut L, Rudolph U, Crestani F. α2-γ-Aminobutyric acid (GABA)A receptors are the molecular substrates mediating precipitation of narcosis but not of sedation by the combined use of diazepam and alcohol in vivo European Journal of Neuroscience. 18: 2599-2604. DOI: 10.1046/j.1460-9568.2003.02988.x  0.64
2002 Crestani F, Assandri R, Täuber M, Martin JR, Rudolph U. Contribution of the alpha1-GABA(A) receptor subtype to the pharmacological actions of benzodiazepine site inverse agonists. Neuropharmacology. 43: 679-84. PMID 12367613 DOI: 10.1016/S0028-3908(02)00159-4  0.64
2002 Ohman L, Franzén L, Rudolph U, Birnbaumer L, Hörnquist EH. Regression of Peyer's patches in G alpha i2 deficient mice prior to colitis is associated with reduced expression of Bcl-2 and increased apoptosis. Gut. 51: 392-7. PMID 12171962 DOI: 10.1136/gut.51.3.392  0.64
2002 Crestani F, Keist R, Fritschy JM, Benke D, Vogt K, Prut L, Blüthmann H, Möhler H, Rudolph U. Trace fear conditioning involves hippocampal alpha5 GABA(A) receptors. Proceedings of the National Academy of Sciences of the United States of America. 99: 8980-5. PMID 12084936 DOI: 10.1073/pnas.142288699  0.68
2002 Siegwart R, Jurd R, Rudolph U. Molecular determinants for the action of general anesthetics at recombinant alpha(2)beta(3)gamma(2)gamma-aminobutyric acid(A) receptors. Journal of Neurochemistry. 80: 140-8. PMID 11796752 DOI: 10.1046/j.0022-3042.2001.00682.x  0.64
2002 Jiang M, Spicher K, Boulay G, Martín-Requero A, Dye CA, Rudolph U, Birnbaumer L. Mouse gene knockout and knockin strategies in application to alpha subunits of Gi/Go family of G proteins. Methods in Enzymology. 344: 277-98. PMID 11771389 DOI: 10.1016/S0076-6879(02)44721-0  0.64
2002 Möhler H, Fritschy JM, Rudolph U. A new benzodiazepine pharmacology. The Journal of Pharmacology and Experimental Therapeutics. 300: 2-8. PMID 11752090 DOI: 10.1124/jpet.300.1.2  0.68
2001 Rudolph U. Identification of molecular substrate for the attenuation of anxiety: a step toward the development of better anti-anxiety drugs. Thescientificworldjournal. 1: 192-3. PMID 12805666 DOI: 10.1100/tsw.2001.33  0.64
2001 Uhlig HH, Hultgren Hörnquist E, Ohman Bache L, Rudolph U, Birnbaumer L, Mothes T. Antibody response to dietary and autoantigens in G alpha i2-deficient mice. European Journal of Gastroenterology & Hepatology. 13: 1421-9. PMID 11742190 DOI: 10.1097/00042737-200112000-00005  0.64
2001 Möhler H, Crestani F, Rudolph U. GABA(A)-receptor subtypes: a new pharmacology. Current Opinion in Pharmacology. 1: 22-5. PMID 11712530 DOI: 10.1016/S1471-4892(01)00008-X  0.64
2001 Crestani F, Möhler H, Rudolph U. Anxiolytic-like action of diazepam: Which GABAA receptor subtype is involved? [1] Trends in Pharmacological Sciences. 22: 402-403. PMID 11515499  0.64
2001 Tobler I, Kopp C, Deboer T, Rudolph U. Diazepam-induced changes in sleep: role of the alpha 1 GABA(A) receptor subtype. Proceedings of the National Academy of Sciences of the United States of America. 98: 6464-9. PMID 11353839 DOI: 10.1073/pnas.111055398  0.64
2001 Rudolph U, Crestani F, Möhler H. GABA(A) receptor subtypes: dissecting their pharmacological functions. Trends in Pharmacological Sciences. 22: 188-94. PMID 11282419 DOI: 10.1016/S0165-6147(00)01646-1  0.64
2001 Crestani F, Löw K, Keist R, Mandelli M, Möhler H, Rudolph U. Molecular targets for the myorelaxant action of diazepam. Molecular Pharmacology. 59: 442-5. PMID 11179437  0.64
2000 Crestani F, Martin JR, Möhler H, Rudolph U. Mechanism of action of the hypnotic zolpidem in vivo. British Journal of Pharmacology. 131: 1251-4. PMID 11090095 DOI: 10.1038/sj.bjp.0703717  0.64
2000 Crestani F, Martin JR, Möhler H, Rudolph U. Resolving differences in GABAA receptor mutant mouse studies. Nature Neuroscience. 3: 1059. PMID 11036253 DOI: 10.1038/80553  0.64
2000 Löw K, Crestani F, Keist R, Benke D, Brünig I, Benson JA, Fritschy JM, Rülicke T, Bluethmann H, Möhler H, Rudolph U. Molecular and neuronal substrate for the selective attenuation of anxiety. Science (New York, N.Y.). 290: 131-4. PMID 11021797 DOI: 10.1126/science.290.5489.131  0.64
2000 Ohman L, Franzén L, Rudolph U, Harriman GR, Hultgren Hörnquist E. Immune activation in the intestinal mucosa before the onset of colitis in Galphai2-deficient mice. Scandinavian Journal of Immunology. 52: 80-90. PMID 10886787 DOI: 10.1046/j.1365-3083.2000.00759.x  0.64
1999 Rudolph U, Mohler H. Transgenic and targeted mutant mice in drug discovery. Current Opinion in Drug Discovery & Development. 2: 134-41. PMID 19649939  0.64
1999 Rudolph U, Crestani F, Benke D, Brünig I, Benson JA, Fritschy JM, Martin JR, Bluethmann H, Möhler H. Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes. Nature. 401: 796-800. PMID 10548105 DOI: 10.1038/44579  0.64
1999 Rudolph U, Möhler H. Genetically modified animals in pharmacological research: future trends. European Journal of Pharmacology. 375: 327-37. PMID 10443586 DOI: 10.1016/S0014-2999(99)00195-8  0.64
1998 Benson JA, Löw K, Keist R, Mohler H, Rudolph U. Pharmacology of recombinant gamma-aminobutyric acidA receptors rendered diazepam-insensitive by point-mutated alpha-subunits. Febs Letters. 431: 400-4. PMID 9714551 DOI: 10.1016/S0014-5793(98)00803-5  0.64
1998 Fritschy JM, Johnson DK, Mohler H, Rudolph U. Independent assembly and subcellular targeting of GABA(A)-receptor subtypes demonstrated in mouse hippocampal and olfactory neurons in vivo. Neuroscience Letters. 249: 99-102. PMID 9682826 DOI: 10.1016/S0304-3940(98)00397-8  0.64
1998 Mohler H, Luscher B, Fritschy JM, Benke D, Benson J, Rudolph U. GABA(A)-receptor assembly in vivo: lessons from subunit mutant mice. Life Sciences. 62: 1611-5. PMID 9585145 DOI: 10.1016/S0024-3205(98)00116-7  0.68
1998 Jiang M, Gold MS, Boulay G, Spicher K, Peyton M, Brabet P, Srinivasan Y, Rudolph U, Ellison G, Birnbaumer L. Multiple neurological abnormalities in mice deficient in the G protein Go. Proceedings of the National Academy of Sciences of the United States of America. 95: 3269-74. PMID 9501252 DOI: 10.1073/pnas.95.6.3269  0.64
1997 Jiang M, Boulay G, Spicher K, Peyton MJ, Brabet P, Birnbaumer L, Rudolph U. Inactivation of the G alpha i2 and G alpha o genes by homologous recombination. Receptors & Channels. 5: 187-92. PMID 9606722  0.64
1997 Fritschy JM, Benke D, Johnson DK, Mohler H, Rudolph U. GABAA-receptor alpha-subunit is an essential prerequisite for receptor formation in vivo. Neuroscience. 81: 1043-53. PMID 9330366 DOI: 10.1016/S0306-4522(97)00244-3  0.64
1997 Hörnquist CE, Lu X, Rogers-Fani PM, Rudolph U, Shappell S, Birnbaumer L, Harriman GR. G(alpha)i2-deficient mice with colitis exhibit a local increase in memory CD4+ T cells and proinflammatory Th1-type cytokines. Journal of Immunology (Baltimore, Md. : 1950). 158: 1068-77. PMID 9013944  0.64
1996 Mohler H, Fritschy JM, Lüscher B, Rudolph U, Benson J, Benke D. The GABAA receptors. From subunits to diverse functions. Ion Channels. 4: 89-113. PMID 8744207  0.64
1996 Rudolph U, Spicher K, Birnbaumer L. Adenylyl cyclase inhibition and altered G protein subunit expression and ADP-ribosylation patterns in tissues and cells from Gi2 alpha-/-mice. Proceedings of the National Academy of Sciences of the United States of America. 93: 3209-14. PMID 8622915  0.64
1995 Rudolph U, Finegold MJ, Rich SS, Harriman GR, Srinivasan Y, Brabet P, Bradley A, Birnbaumer L. Gi2 alpha protein deficiency: a model of inflammatory bowel disease. Journal of Clinical Immunology. 15: 101S-105S. PMID 8613481 DOI: 10.1007/BF01540899  0.64
1995 Rudolph U, Finegold MJ, Rich SS, Harriman GR, Srinivasan Y, Brabet P, Boulay G, Bradley A, Birnbaumer L. Ulcerative colitis and adenocarcinoma of the colon in G alpha i2-deficient mice. Nature Genetics. 10: 143-50. PMID 7663509 DOI: 10.1038/ng0695-143  0.64
1990 Hsu WH, Rudolph U, Sanford J, Bertrand P, Olate J, Nelson C, Moss LG, Boyd AE, Codina J, Birnbaumer L. Molecular cloning of a novel splice variant of the alpha subunit of the mammalian Go protein. The Journal of Biological Chemistry. 265: 11220-6. PMID 2113531  0.64
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