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Lori A. Knackstedt, Ph.D. - Publications

Affiliations: 
University of California, Santa Barbara, Santa Barbara, CA, United States 
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53 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Mesa JR, Carter E, Padovan-Hernandez Y, Knackstedt LA. Alcohol consumption modulates prelimbic cortex response to cocaine following sequential cocaine and alcohol polysubstance use in the rat. Frontiers in Pharmacology. 14: 1132689. PMID 37007027 DOI: 10.3389/fphar.2023.1132689  0.638
2022 Padovan-Hernandez Y, Rojas G, Wu L, Knackstedt LA. Individual differences in cocaine seeking during voluntary abstinence predicts cocaine relapse and the circuitry mediating relapse. Psychopharmacology. 239: 3963-3973. PMID 36329194 DOI: 10.1007/s00213-022-06270-x  0.599
2022 Mesa JR, Wesson DW, Schwendt M, Knackstedt LA. The roles of rat medial prefrontal and orbitofrontal cortices in relapse to cocaine-seeking: A comparison across methods for identifying neurocircuits. Addiction Neuroscience. 4. PMID 36277334 DOI: 10.1016/j.addicn.2022.100031  0.57
2022 Peart DR, Andrade AK, Logan CN, Knackstedt LA, Murray JE. Regulation of cocaine-related behaviours by estrogen and progesterone. Neuroscience and Biobehavioral Reviews. 135: 104584. PMID 35189163 DOI: 10.1016/j.neubiorev.2022.104584  0.603
2021 Schwendt M, Knackstedt LA. Extinction vs. Abstinence: A Review of the Molecular and Circuit Consequences of Different Post-Cocaine Experiences. International Journal of Molecular Sciences. 22. PMID 34204090 DOI: 10.3390/ijms22116113  0.624
2021 Knackstedt LA, Wu L, Rothstein JD, Vidensky S, Gordon J, Ramanjulu M, Dunman P, Blass B, Childers W, Abou-Gharbia M. MC-100093, a novel β-lactam GLT-1 enhancer devoid of antimicrobial properties attenuates cocaine relapse in rats. The Journal of Pharmacology and Experimental Therapeutics. PMID 33986035 DOI: 10.1124/jpet.121.000532  0.654
2021 Niedzielska-Andres E, Pomierny-Chamioło L, Andres M, Walczak M, Knackstedt LA, Filip M, Przegaliński E. Cocaine use disorder: A look at metabotropic glutamate receptors and glutamate transporters. Pharmacology & Therapeutics. 221: 107797. PMID 33359590 DOI: 10.1016/j.pharmthera.2020.107797  0.569
2020 Fischer KD, Knackstedt LA, Rosenberg PA. Glutamate homeostasis and dopamine signaling: implications for psychostimulant addiction behavior. Neurochemistry International. 104896. PMID 33159978 DOI: 10.1016/j.neuint.2020.104896  0.503
2020 Stennett BA, Knackstedt LA. A Rat Model of Cocaine-Alcohol Polysubstance Use Reveals Altered Cocaine Seeking and Glutamate Levels in the Nucleus Accumbens. Frontiers in Neuroscience. 14: 877. PMID 32982672 DOI: 10.3389/Fnins.2020.00877  0.706
2020 Hadad NA, Schwendt M, Knackstedt LA. Hypothalamic-pituitary-adrenal axis activity in post-traumatic stress disorder and cocaine use disorder. Stress (Amsterdam, Netherlands). 1-13. PMID 32835581 DOI: 10.1080/10253890.2020.1803824  0.499
2020 Bechard AR, Logan CN, Mesa J, Padovan-Hernandez Y, Blount H, Hodges VL, Knackstedt LA. Role of prefrontal cortex projections to the nucleus accumbens core in mediating the effects of ceftriaxone on cue-induced cocaine seeking. Addiction Biology. e12928. PMID 32558119 DOI: 10.1111/Adb.12928  0.678
2020 Smaga I, Fierro D, Mesa J, Filip M, Knackstedt LA. Molecular changes evoked by the beta-lactam antibiotic ceftriaxone across rodent models of substance use disorder and neurological disease. Neuroscience and Biobehavioral Reviews. PMID 32485268 DOI: 10.1016/J.Neubiorev.2020.05.016  0.301
2020 Logan CN, Bechard AR, Hamor PU, Wu L, Schwendt M, Knackstedt LA. Ceftriaxone and mGlu2/3 interactions in the nucleus accumbens core affect the reinstatement of cocaine-seeking in male and female rats. Psychopharmacology. PMID 32382781 DOI: 10.1007/S00213-020-05514-Y  0.638
2019 Stennett BA, Padovan-Hernandez Y, Knackstedt LA. Sequential cocaine-alcohol self-administration produces adaptations in rat nucleus accumbens core glutamate homeostasis that are distinct from those produced by cocaine self-administration alone. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 31266052 DOI: 10.1038/S41386-019-0452-2  0.706
2019 Shallcross J, Hámor P, Bechard AR, Romano M, Knackstedt L, Schwendt M. The Divergent Effects of CDPPB and Cannabidiol on Fear Extinction and Anxiety in a Predator Scent Stress Model of PTSD in Rats. Frontiers in Behavioral Neuroscience. 13: 91. PMID 31133832 DOI: 10.3389/Fnbeh.2019.00091  0.328
2019 Bechard AR, Knackstedt LA. The effects of Pavlovian cue extinction and ceftriaxone on cocaine relapse after abstinence. Drug and Alcohol Dependence. 197: 83-86. PMID 30784953 DOI: 10.1016/J.Drugalcdep.2019.01.005  0.69
2019 Bechard AR, Hamor PU, Wu L, Schwendt M, Knackstedt LA. The effects of clavulanic acid and amoxicillin on cue-primed reinstatement of cocaine seeking. Behavioral Neuroscience. PMID 30714803 DOI: 10.1037/Bne0000297  0.679
2018 Schwendt M, Shallcross J, Hadad NA, Namba MD, Hiller H, Wu L, Krause EG, Knackstedt LA. A novel rat model of comorbid PTSD and addiction reveals intersections between stress susceptibility and enhanced cocaine seeking with a role for mGlu5 receptors. Translational Psychiatry. 8: 209. PMID 30291225 DOI: 10.1038/S41398-018-0265-9  0.792
2018 Bechard AR, LaCrosse A, Namba MD, Jackson B, Knackstedt LA. Impairments in reversal learning following short access to cocaine self-administration. Drug and Alcohol Dependence. 192: 239-244. PMID 30278419 DOI: 10.1016/J.Drugalcdep.2018.08.008  0.797
2018 Liu Y, Williamson V, Setlow B, Cottler LB, Knackstedt LA. The importance of considering polysubstance use: lessons from cocaine research. Drug and Alcohol Dependence. 192: 16-28. PMID 30195242 DOI: 10.1016/J.Drugalcdep.2018.07.025  0.531
2018 Padovan-Hernandez Y, Knackstedt LA. Dose-dependent reduction in cocaine-induced locomotion by Clozapine-N-Oxide in rats with a history of cocaine self-administration. Neuroscience Letters. 674: 132-135. PMID 29571824 DOI: 10.1016/J.Neulet.2018.03.045  0.672
2018 Logan CN, LaCrosse AL, Knackstedt LA. Nucleus accumbens GLT-1a overexpression reduces glutamate efflux during reinstatement of cocaine-seeking but is not sufficient to attenuate reinstatement. Neuropharmacology. 135: 297-307. PMID 29567092 DOI: 10.1016/J.Neuropharm.2018.03.022  0.703
2018 Weber RA, Logan CN, Leong KC, Peris J, Knackstedt L, Reichel CM. Regionally Specific Effects of Oxytocin on Reinstatement of Cocaine Seeking in Male and Female Rats. The International Journal of Neuropsychopharmacology. PMID 29566161 DOI: 10.1093/Ijnp/Pyy025  0.591
2017 Bechard AR, Hamor PU, Schwendt M, Knackstedt LA. The effects of ceftriaxone on cue-primed reinstatement of cocaine-seeking in male and female rats: estrous cycle effects on behavior and protein expression in the nucleus accumbens. Psychopharmacology. PMID 29197981 DOI: 10.1007/S00213-017-4802-7  0.663
2017 Stennett BA, Frankowski JC, Peris J, Knackstedt LA. Ceftriaxone reduces alcohol intake in outbred rats while upregulating xCT in the nucleus accumbens core. Pharmacology, Biochemistry, and Behavior. PMID 28687200 DOI: 10.1016/J.Pbb.2017.07.001  0.323
2017 Lacrosse AL, O'Donovan SM, Sepulveda-Orengo MT, McCullumsmith RE, Reissner KJ, Schwendt M, Knackstedt LA. Contrasting the role of xCT and GLT-1 upregulation in the ability of ceftriaxone to attenuate the cue-induced reinstatement of cocaine-seeking and normalize AMPA receptor subunit expression. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28495973 DOI: 10.1523/Jneurosci.3717-16.2017  0.624
2016 Pati D, Kelly K, Stennett B, Frazier CJ, Knackstedt LA. Alcohol consumption increases basal extracellular glutamate in the nucleus accumbens core of Sprague-Dawley rats without increasing spontaneous glutamate release. The European Journal of Neuroscience. PMID 27207718 DOI: 10.1111/Ejn.13284  0.374
2016 Hadad NA, Wu L, Hiller H, Krause EG, Schwendt M, Knackstedt LA. Conditioned stress prevents cue-primed cocaine reinstatement only in stress-responsive rats. Stress (Amsterdam, Netherlands). 1-49. PMID 27181613 DOI: 10.1080/10253890.2016.1189898  0.604
2016 Knackstedt LA, Schwendt M. mGlu5 Receptors and Relapse to Cocaine-Seeking: The Role of Receptor Trafficking in Postrelapse Extinction Learning Deficits. Neural Plasticity. 2016: 9312508. PMID 26881139 DOI: 10.1155/2016/9312508  0.59
2015 LaCrosse AL, Hill K, Knackstedt LA. Ceftriaxone attenuates cocaine relapse after abstinence through modulation of nucleus accumbens AMPA subunit expression. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. PMID 26706696 DOI: 10.1016/J.Euroneuro.2015.12.022  0.653
2015 Massie A, Boillée S, Hewett S, Knackstedt L, Lewerenz J. Main path and byways: non-vesicular glutamate release by system xc (-) as an important modifier of glutamatergic neurotransmission. Journal of Neurochemistry. PMID 26336934 DOI: 10.1111/Jnc.13348  0.3
2015 Weiland A, Garcia S, Knackstedt LA. Ceftriaxone and cefazolin attenuate the cue-primed reinstatement of alcohol-seeking. Frontiers in Pharmacology. 6: 44. PMID 25805996 DOI: 10.3389/Fphar.2015.00044  0.466
2015 Griffin WC, Ramachandra VS, Knackstedt LA, Becker HC. Repeated cycles of chronic intermittent ethanol exposure increases basal glutamate in the nucleus accumbens of mice without affecting glutamate transport. Frontiers in Pharmacology. 6: 27. PMID 25755641 DOI: 10.3389/Fphar.2015.00027  0.358
2015 Reissner KJ, Gipson CD, Tran PK, Knackstedt LA, Scofield MD, Kalivas PW. Glutamate transporter GLT-1 mediates N-acetylcysteine inhibition of cocaine reinstatement. Addiction Biology. 20: 316-23. PMID 24612076 DOI: 10.1111/Adb.12127  0.765
2014 Hadad NA, Knackstedt LA. Addicted to palatable foods: comparing the neurobiology of Bulimia Nervosa to that of drug addiction. Psychopharmacology. 231: 1897-912. PMID 24500676 DOI: 10.1007/S00213-014-3461-1  0.402
2014 Knackstedt LA, Trantham-Davidson HL, Schwendt M. The role of ventral and dorsal striatum mGluR5 in relapse to cocaine-seeking and extinction learning. Addiction Biology. 19: 87-101. PMID 23710649 DOI: 10.1111/Adb.12061  0.704
2013 Alajaji M, Bowers MS, Knackstedt L, Damaj MI. Effects of the beta-lactam antibiotic ceftriaxone on nicotine withdrawal and nicotine-induced reinstatement of preference in mice. Psychopharmacology. 228: 419-26. PMID 23503685 DOI: 10.1007/S00213-013-3047-3  0.353
2013 Wang X, Moussawi K, Knackstedt L, Shen H, Kalivas PW. Role of mGluR5 neurotransmission in reinstated cocaine-seeking. Addiction Biology. 18: 40-9. PMID 22340009 DOI: 10.1111/J.1369-1600.2011.00432.X  0.737
2013 Knackstedt LA. Neuropharmacology of Cocaine and Amphetamine Biological Research On Addiction. 573-577. DOI: 10.1016/B978-0-12-398335-0.00056-X  0.611
2012 Trantham-Davidson H, LaLumiere RT, Reissner KJ, Kalivas PW, Knackstedt LA. Ceftriaxone normalizes nucleus accumbens synaptic transmission, glutamate transport, and export following cocaine self-administration and extinction training. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 12406-10. PMID 22956831 DOI: 10.1523/Jneurosci.1976-12.2012  0.807
2011 Sondheimer I, Knackstedt LA. Ceftriaxone prevents the induction of cocaine sensitization and produces enduring attenuation of cue- and cocaine-primed reinstatement of cocaine-seeking. Behavioural Brain Research. 225: 252-8. PMID 21824497 DOI: 10.1016/J.Bbr.2011.07.041  0.712
2011 Uys JD, Knackstedt L, Hurt P, Tew KD, Manevich Y, Hutchens S, Townsend DM, Kalivas PW. Cocaine-induced adaptations in cellular redox balance contributes to enduring behavioral plasticity. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 2551-60. PMID 21796101 DOI: 10.1038/Npp.2011.143  0.764
2010 Knackstedt LA, Moussawi K, Lalumiere R, Schwendt M, Klugmann M, Kalivas PW. Extinction training after cocaine self-administration induces glutamatergic plasticity to inhibit cocaine seeking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 7984-92. PMID 20534846 DOI: 10.1523/Jneurosci.1244-10.2010  0.795
2010 Knackstedt LA, Melendez RI, Kalivas PW. Ceftriaxone restores glutamate homeostasis and prevents relapse to cocaine seeking. Biological Psychiatry. 67: 81-4. PMID 19717140 DOI: 10.1016/J.Biopsych.2009.07.018  0.757
2009 Knackstedt LA, Kalivas PW. Glutamate and reinstatement. Current Opinion in Pharmacology. 9: 59-64. PMID 19157986 DOI: 10.1016/J.Coph.2008.12.003  0.717
2009 Knackstedt LA, LaRowe S, Mardikian P, Malcolm R, Upadhyaya H, Hedden S, Markou A, Kalivas PW. The role of cystine-glutamate exchange in nicotine dependence in rats and humans. Biological Psychiatry. 65: 841-5. PMID 19103434 DOI: 10.1016/J.Biopsych.2008.10.040  0.568
2009 Kalivas PW, Lalumiere RT, Knackstedt L, Shen H. Glutamate transmission in addiction. Neuropharmacology. 56: 169-73. PMID 18675832 DOI: 10.1016/J.Neuropharm.2008.07.011  0.717
2007 Knackstedt LA, Kalivas PW. Extended access to cocaine self-administration enhances drug-primed reinstatement but not behavioral sensitization. The Journal of Pharmacology and Experimental Therapeutics. 322: 1103-9. PMID 17601982 DOI: 10.1124/Jpet.107.122861  0.732
2006 Kalivas PW, Peters J, Knackstedt L. Animal models and brain circuits in drug addiction. Molecular Interventions. 6: 339-44. PMID 17200461 DOI: 10.1124/Mi.6.6.7  0.629
2006 Knackstedt LA, Ben-Shahar O, Ettenberg A. Alcohol consumption is preferred to water in rats pretreated with intravenous cocaine. Pharmacology, Biochemistry, and Behavior. 85: 281-6. PMID 17049976 DOI: 10.1016/J.Pbb.2006.08.012  0.783
2006 Knackstedt LA, Kalivas PW. Pharmacotherapeutic targets for regulating cocaine-induced plasticity Drugs of the Future. 31: 893-900. DOI: 10.1358/Dof.2006.031.10.1036835  0.723
2005 Knackstedt LA, Ettenberg A. Ethanol consumption reduces the adverse consequences of self-administered intravenous cocaine in rats. Psychopharmacology. 178: 143-50. PMID 15338105 DOI: 10.1007/S00213-004-1996-2  0.783
2002 Knackstedt LA, Samimi MM, Ettenberg A. Evidence for opponent-process actions of intravenous cocaine and cocaethylene. Pharmacology, Biochemistry, and Behavior. 72: 931-6. PMID 12062583 DOI: 10.1016/S0091-3057(02)00764-5  0.698
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