Nikolaus R. McFarland, Ph.D. - Publications

Affiliations: 
1988-1992 University of Chicago, Chicago, IL 
 1992-2002 University of Rochester, Rochester, NY 
 2002-2006 Neurology University of Virginia School of Medicine, Charlottesville, VA, United States 
 2006-2010 Neurology Massachusetts General Hospital & Harvard Medical School, Boston, MA, United States 
 2010- Neurology University of Florida College of Medicine 
Area:
Parkinsonism, atypical parkinson disorders, neurodegenerative models, AAV
Website:
https://movementdisorders.ufhealth.org/team/faculty-fellows/nikolaus-mcfarland-m-d-ph-d/

67 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Hass EW, Sorrentino ZA, Lloyd GM, McFarland NR, Prokop S, Giasson BI. Robust α-synuclein pathology in select brainstem neuronal populations is a potential instigator of multiple system atrophy. Acta Neuropathologica Communications. 9: 80. PMID 33941284 DOI: 10.1186/s40478-021-01173-y  0.44
2021 Tanner CM, Cummings SR, Schwarzschild MA, Brown EG, Dorsey ER, Espay AJ, Galifianakis NB, Goldman SM, Litvan I, Luthra N, McFarland NR, Mitchell KT, Standaert DG, Bauer DC, Greenspan SL, et al. The TOPAZ study: a home-based trial of zoledronic acid to prevent fractures in neurodegenerative parkinsonism. Npj Parkinson's Disease. 7: 16. PMID 33649343 DOI: 10.1038/s41531-021-00162-1  1
2020 Quattrone A, Antonini A, Vaillancourt DE, Seppi K, Ceravolo R, Strafella AP, Morelli M, Nigro S, Vescio B, Bianco MG, Vasta R, Arcuri PP, Weis L, Fiorenzato E, Biundo R, ... ... McFarland NR, et al. A New MRI Measure to Early Differentiate Progressive Supranuclear Palsy From De Novo Parkinson's Disease in Clinical Practice: An International Study. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 33151015 DOI: 10.1002/mds.28364  1
2020 Archer DB, Mitchell T, Burciu RG, Yang J, Nigro S, Quattrone A, Quattrone A, Jeromin A, McFarland NR, Okun MS, Vaillancourt DE. Magnetic Resonance Imaging and Neurofilament Light in the Differentiation of Parkinsonism. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 32357259 DOI: 10.1002/Mds.28060  1
2020 Nigro S, Antonini A, Vaillancourt DE, Seppi K, Ceravolo R, Strafella AP, Augimeri A, Quattrone A, Morelli M, Weis L, Fiorenzato E, Biundo R, Burciu RG, Krismer F, McFarland NR, et al. Automated MRI Classification in Progressive Supranuclear Palsy: a Large International Cohort Study. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 32092195 DOI: 10.1002/Mds.28007  1
2020 Julayanont P, Heilman KM, McFarland NR. Early-motor phenotype relates to neuropsychiatric and cognitive disorders in huntington's disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 31922295 DOI: 10.1002/Mds.27980  1
2019 Archer DB, Bricker JT, Chu WT, Burciu RG, McCracken JL, Lai S, Coombes SA, Fang R, Barmpoutis A, Corcos DM, Kurani AS, Mitchell T, Black ML, Herschel E, Simuni T, ... ... McFarland NR, et al. Development and validation of the automated imaging differentiation in parkinsonism (AID-P): a multicentre machine learning study. The Lancet. Digital Health. 1: e222-e231. PMID 33323270 DOI: 10.1016/S2589-7500(19)30105-0  1
2019 Archer DB, Bricker JT, Chu WT, Burciu RG, Mccracken JL, Lai S, Coombes SA, Fang R, Barmpoutis A, Corcos DM, Kurani AS, Mitchell T, Black ML, Herschel E, Simuni T, ... ... McFarland NR, et al. Development and Validation of the Automated Imaging Differentiation in Parkinsonism (AID-P): A Multi-Site Machine Learning Study. The Lancet. Digital Health. 1: e222-e231. PMID 32259098 DOI: 10.1016/s2589-7500(19)30105-0  1
2019 Julayanont P, McFarland NR, Heilman KM. Mild cognitive impairment and dementia in motor manifest Huntington's disease: Classification and prevalence. Journal of the Neurological Sciences. 408: 116523. PMID 31678902 DOI: 10.1016/J.Jns.2019.116523  1
2019 Baudendistel ST, Schmitt AC, Rodriguez AV, McFarland NR, Hass CJ. A turn for the worse: Turning performance in Parkinson's disease and Essential tremor. Clinical Biomechanics (Bristol, Avon). 70: 245-248. PMID 31669958 DOI: 10.1016/J.Clinbiomech.2019.09.008  1
2019 Mitchell T, Archer DB, Chu WT, Coombes SA, Lai S, Wilkes BJ, McFarland NR, Okun MS, Black ML, Herschel E, Simuni T, Comella C, Xie T, Li H, Parrish TB, et al. Neurite orientation dispersion and density imaging (NODDI) and free-water imaging in Parkinsonism. Human Brain Mapping. PMID 31403737 DOI: 10.1002/Hbm.24760  1
2019 Archer DB, Coombes SA, McFarland NR, DeKosky ST, Vaillancourt DE. Development of a transcallosal tractography template and its application to dementia. Neuroimage. PMID 31260838 DOI: 10.1016/J.Neuroimage.2019.06.065  1
2019 Dhillon JS, Trejo-Lopez JA, Riffe C, McFarland NR, Hiser WM, Giasson BI, Yachnis AT. Dissecting α-synuclein inclusion pathology diversity in multiple system atrophy: implications for the prion-like transmission hypothesis. Laboratory Investigation; a Journal of Technical Methods and Pathology. PMID 30737468 DOI: 10.1038/S41374-019-0198-9  1
2017 Almeida L, Ahmed B, Walz R, De Jesus S, Patterson A, Martinez-Ramirez D, Vaillancourt D, Bowers D, Ward H, Okun MS, McFarland NR. Depressive Symptoms are Frequent in Atypical Parkinsonian Disorders. Movement Disorders Clinical Practice. 4: 191-197. PMID 28944256 DOI: 10.1002/Mdc3.12382  1
2017 Burciu RG, Ofori E, Archer DB, Wu SS, Pasternak O, McFarland NR, Okun MS, Vaillancourt DE. Progression marker of Parkinson's disease: a 4-year multi-site imaging study. Brain : a Journal of Neurology. 140: 2183-2192. PMID 28899020 DOI: 10.1093/Brain/Awx146  1
2017 Ofori E, Krismer F, Burciu RG, Pasternak O, McCracken JL, Lewis MM, Du G, McFarland NR, Okun MS, Poewe W, Mueller C, Gizewski ER, Schocke M, Kremser C, Li H, et al. Free water improves detection of changes in the substantia nigra in parkinsonism: A multisite study. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 28714593 DOI: 10.1002/Mds.27100  1
2017 Burciu RG, Hess CW, Coombes SA, Ofori E, Shukla P, Chung JW, McFarland NR, Wagle Shukla A, Okun MS, Vaillancourt DE. Functional activity of the sensorimotor cortex and cerebellum relates to cervical dystonia symptoms. Human Brain Mapping. PMID 28594097 DOI: 10.1002/Hbm.23684  1
2017 McFarland NR, McFarland KN, Golde TE. Parkinson Disease and Autoimmune Disorders-What Can We Learn From Genome-wide Pleiotropy? Jama Neurology. PMID 28586798 DOI: 10.1001/Jamaneurol.2017.0843  1
2017 McFarland NR, Hess CW. Recognizing Atypical Parkinsonisms: "Red Flags" and Therapeutic Approaches. Seminars in Neurology. 37: 215-227. PMID 28511262 DOI: 10.1055/S-0037-1602422  0.92
2016 Burciu RG, Chung JW, Shukla P, Ofori E, Li H, McFarland NR, Okun MS, Vaillancourt DE. Functional MRI of disease progression in Parkinson disease and atypical parkinsonian syndromes. Neurology. PMID 27421545 DOI: 10.1212/Wnl.0000000000002985  1
2016 Burciu RG, Ofori E, Shukla P, Pasternak O, Chung JW, McFarland NR, Okun MS, Vaillancourt DE. Free-water and BOLD imaging changes in Parkinson's disease patients chronically treated with a MAO-B inhibitor. Human Brain Mapping. PMID 27089850 DOI: 10.1002/Hbm.23213  1
2016 Lee HK, Altmann LJ, McFarland N, Hass CJ. The relationship between balance confidence and control in individuals with Parkinson's disease. Parkinsonism & Related Disorders. PMID 26949065 DOI: 10.1016/J.Parkreldis.2016.02.015  1
2015 Stegemöller EL, Uzochukwu J, Tillman MD, McFarland NR, Subramony SH, Okun MS, Hass CJ. Repetitive finger movement performance differs among Parkinson's disease, Progressive Supranuclear Palsy, and spinocerebellar ataxia. Journal of Clinical Movement Disorders. 2: 6. PMID 26788342 DOI: 10.1186/s40734-014-0015-y  1
2015 Planetta PJ, Ofori E, Pasternak O, Burciu RG, Shukla P, DeSimone JC, Okun MS, McFarland NR, Vaillancourt DE. Free-water imaging in Parkinson's disease and atypical parkinsonism. Brain : a Journal of Neurology. PMID 26705348 DOI: 10.1093/Brain/Awv361  1
2015 Kesayan T, Lamb DG, Falchook AD, Williamson JB, Salazar L, Malaty IA, McFarland NR, Okun MS, Wagle Shukla A, Heilman KM. Abnormal tactile pressure perception in Parkinson's disease. Journal of Clinical and Experimental Neuropsychology. 37: 808-15. PMID 26313511 DOI: 10.1080/13803395.2015.1060951  1
2015 Ceballos-Diaz C, Rosario AM, Park HJ, Chakrabarty P, Sacino A, Cruz PE, Siemienski Z, Lara N, Moran C, Ravelo N, Golde TE, McFarland NR. Viral expression of ALS-linked ubiquilin-2 mutants causes inclusion pathology and behavioral deficits in mice. Molecular Neurodegeneration. 10: 25. PMID 26152284 DOI: 10.1186/S13024-015-0026-7  1
2015 Burciu RG, Ofori E, Shukla P, Planetta PJ, Snyder AF, Li H, Hass CJ, Okun MS, McFarland NR, Vaillancourt DE. Distinct patterns of brain activity in progressive supranuclear palsy and Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 26148135 DOI: 10.1002/Mds.26294  1
2015 Amano S, Skinner JW, Lee HK, Stegemöller EL, Hack N, Akbar U, Vaillancourt D, McFarland NR, Hass CJ. Discriminating features of gait performance in progressive supranuclear palsy. Parkinsonism & Related Disorders. 21: 888-93. PMID 26032992 DOI: 10.1016/J.Parkreldis.2015.05.017  1
2015 Altmann LJ, Stegemöller E, Hazamy AA, Wilson JP, Okun MS, McFarland NR, Wagle Shukla A, Hass CJ. Unexpected dual task benefits on cycling in Parkinson disease and healthy adults: a neuro-behavioral model. Plos One. 10: e0125470. PMID 25970607 DOI: 10.1371/Journal.Pone.0125470  1
2015 Akbar U, He Y, Dai Y, Hack N, Malaty I, McFarland NR, Hess C, Schmidt P, Wu S, Okun MS. Weight loss and impact on quality of life in Parkinson's disease. Plos One. 10: e0124541. PMID 25938478 DOI: 10.1371/Journal.Pone.0124541  1
2015 Planetta PJ, Kurani AS, Shukla P, Prodoehl J, Corcos DM, Comella CL, McFarland NR, Okun MS, Vaillancourt DE. Distinct functional and macrostructural brain changes in Parkinson's disease and multiple system atrophy. Human Brain Mapping. 36: 1165-79. PMID 25413603 DOI: 10.1002/Hbm.22694  1
2015 Falchook AD, Salazar L, Neal D, Kesayan T, Williamson JB, Malaty IA, McFarland NR, Okun MS, Rodriguez RL, Wagle Shukla A, Heilman KM. Global attentional neglect of segmented lines in Parkinson's disease. Neurocase. 21: 501-8. PMID 25073971 DOI: 10.1080/13554794.2014.942671  1
2015 Ceballos-Diaz C, Rosario AM, Park HJ, Chakrabarty P, Sacino A, Cruz PE, Siemienski Z, Lara N, Moran C, Ravelo N, Golde TE, McFarland NR. Viral expression of ALS-linked ubiquilin-2 mutants causes inclusion pathology and behavioral deficits in mice Molecular Neurodegeneration. DOI: 10.1186/s13024-015-0026-7  1
2015 Burciu RG, Ofori E, Shukla P, Planetta PJ, Snyder AF, Li H, Hass CJ, Okun MS, Mcfarland NR, Vaillancourt DE. Distinct patterns of brain activity in progressive supranuclear palsy and Parkinson's disease Movement Disorders. DOI: 10.1002/mds.26294  1
2014 Hass CJ, Bishop M, Moscovich M, Stegemöller EL, Skinner J, Malaty IA, Wagle Shukla A, McFarland N, Okun MS. Defining the clinically meaningful difference in gait speed in persons with Parkinson disease. Journal of Neurologic Physical Therapy : Jnpt. 38: 233-8. PMID 25198866 DOI: 10.1097/Npt.0000000000000055  1
2014 Martinez-Ramirez D, Giugni J, Vedam-Mai V, Shukla AW, Malaty IA, McFarland NR, Rodriguez RL, Foote KD, Okun MS. The "brittle response" to Parkinson's disease medications: characterization and response to deep brain stimulation. Plos One. 9: e94856. PMID 24733172 DOI: 10.1371/Journal.Pone.0094856  1
2014 Hack N, Fayad SM, Monari EH, Akbar U, Hardwick A, Rodriguez RL, Malaty IA, Romrell J, Shukla AA, McFarland N, Ward HE, Okun MS. An eight-year clinic experience with clozapine use in a Parkinson's disease clinic setting. Plos One. 9: e91545. PMID 24646688 DOI: 10.1371/Journal.Pone.0091545  1
2014 McFarland NR, Dimant H, Kibuuka L, Ebrahimi-Fakhari D, Desjardins CA, Danzer KM, Danzer M, Fan Z, Schwarzschild MA, Hirst W, McLean PJ. Chronic treatment with novel small molecule Hsp90 inhibitors rescues striatal dopamine levels but not α-synuclein-induced neuronal cell loss. Plos One. 9: e86048. PMID 24465863 DOI: 10.1371/Journal.Pone.0086048  1
2014 Classen S, Brumback B, Monahan M, Malaty II, Rodriguez RL, Okun MS, McFarland NR. Driving errors in Parkinson's disease: moving closer to predicting on-road outcomes. The American Journal of Occupational Therapy : Official Publication of the American Occupational Therapy Association. 68: 77-85. PMID 24367958 DOI: 10.5014/Ajot.2014.008698  1
2014 Planetta PJ, McFarland NR, Okun MS, Vaillancourt DE. MRI reveals brain abnormalities in drug-naive Parkinson's disease. Exercise and Sport Sciences Reviews. 42: 12-22. PMID 24188978 DOI: 10.1249/Jes.0000000000000003  1
2013 Dimant H, Kalia SK, Kalia LV, Zhu LN, Kibuuka L, Ebrahimi-Fakhari D, McFarland NR, Fan Z, Hyman BT, McLean PJ. Direct detection of alpha synuclein oligomers in vivo. Acta Neuropathologica Communications. 1: 6. PMID 24252244 DOI: 10.1186/2051-5960-1-6  1
2013 Golde TE, Lewis J, McFarland NR. Anti-tau antibodies: hitting the target. Neuron. 80: 254-6. PMID 24139027 DOI: 10.1016/J.Neuron.2013.10.009  1
2013 Crizzle AM, Classen S, Lanford DN, Malaty IA, Okun MS, Wang Y, Wagle Shukla A, Rodriguez RL, McFarland NR. Postural/Gait and cognitive function as predictors of driving performance in Parkinson's disease. Journal of Parkinson's Disease. 3: 153-60. PMID 23938345 DOI: 10.3233/JPD-120152  1
2013 Thompson AJ, Scholz SW, Singleton AB, Hardwick A, McFarland NR, Okun MS. Variability in clinical phenotypes of heterozygous and homozygous cases of Parkin-related Parkinson's disease. The International Journal of Neuroscience. 123: 847-9. PMID 23767969 DOI: 10.3109/00207454.2013.810626  1
2013 Crizzle AM, Classen S, Lanford D, Malaty IA, Okun MS, Wagle Shukla A, McFarland NR. Driving performance and behaviors: a comparison of gender differences in Parkinson's disease. Traffic Injury Prevention. 14: 340-5. PMID 23531256 DOI: 10.1080/15389588.2012.717730  1
2013 McFarland NR, Burdett T, Desjardins CA, Frosch MP, Schwarzschild MA. Postmortem brain levels of urate and precursors in Parkinson's disease and related disorders. Neuro-Degenerative Diseases. 12: 189-98. PMID 23467193 DOI: 10.1159/000346370  1
2013 McFarland NR, Okun MS. Movement disorders in 2012: Advancing research towards novel therapeutic approaches. Nature Reviews. Neurology. 9: 70-1. PMID 23296342 DOI: 10.1038/Nrneurol.2012.265  1
2013 Sriram A, Ward HE, Hassan A, Iyer S, Foote KD, Rodriguez RL, McFarland NR, Okun MS. Valproate as a treatment for dopamine dysregulation syndrome (DDS) in Parkinson's disease. Journal of Neurology. 260: 521-7. PMID 23007193 DOI: 10.1007/S00415-012-6669-1  1
2013 Burdett TC, Desjardins CA, Logan R, McFarland NR, Chen X, Schwarzschild MA. Efficient determination of purine metabolites in brain tissue and serum by high-performance liquid chromatography with electrochemical and UV detection. Biomedical Chromatography : Bmc. 27: 122-9. PMID 22674671 DOI: 10.1002/Bmc.2760  1
2013 McFarland NR, Burdett T, Desjardins CA, Frosch MP, Schwarzschild MA, Nocker M, Scherfler C, Kiechl S, Willeit J, Schmidauer C, Gasperi A, Rungger G, Poewe W, Mahlknecht P, Seppi K, et al. Contents Vol. 12, 2013 Neurodegenerative Diseases. 12. DOI: 10.1159/000355887  1
2012 Guerrero WR, Okun MS, McFarland NR. Encephalopathy, hypoglycemia, and flailing extremities: a case of bilateral chorea-ballism associated with diabetic ketoacidosis. Tremor and Other Hyperkinetic Movements (New York, N.Y.). 2. PMID 23439397  1
2012 Zahodne LB, Bernal-Pacheco O, Bowers D, Ward H, Oyama G, Limotai N, Velez-Lago F, Rodriguez RL, Malaty I, McFarland NR, Okun MS. Are selective serotonin reuptake inhibitors associated with greater apathy in Parkinson's disease? The Journal of Neuropsychiatry and Clinical Neurosciences. 24: 326-30. PMID 23037646 DOI: 10.1176/Appi.Neuropsych.11090210  1
2012 Wang S, Okun MS, Suslov O, Zheng T, McFarland NR, Vedam-Mai V, Foote KD, Roper SN, Yachnis AT, Siebzehnrubl FA, Steindler DA. Neurogenic potential of progenitor cells isolated from postmortem human Parkinsonian brains. Brain Research. 1464: 61-72. PMID 22652067 DOI: 10.1016/J.Brainres.2012.04.039  1
2012 Ullman M, Vedam-Mai V, Resnick AS, Yachnis AT, McFarland NR, Merritt S, Zeilman P, Foote KD, Okun MS. Deep brain stimulation response in pathologically confirmed cases of multiple system atrophy. Parkinsonism & Related Disorders. 18: 86-8. PMID 21983018 DOI: 10.1016/J.Parkreldis.2011.09.008  1
2011 Chakrabarty P, Ceballos-Diaz C, Lin WL, Beccard A, Jansen-West K, McFarland NR, Janus C, Dickson D, Das P, Golde TE. Interferon-γ induces progressive nigrostriatal degeneration and basal ganglia calcification. Nature Neuroscience. 14: 694-6. PMID 21572432 DOI: 10.1038/Nn.2829  1
2009 McFarland NR, Fan Z, Xu K, Schwarzschild MA, Feany MB, Hyman BT, McLean PJ. Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease. Journal of Neuropathology and Experimental Neurology. 68: 515-24. PMID 19525899 DOI: 10.1097/Nen.0B013E3181A24B53  1
2009 McFarland NR, Lee JS, Hyman BT, McLean PJ. Comparison of transduction efficiency of recombinant AAV serotypes 1, 2, 5, and 8 in the rat nigrostriatal system. Journal of Neurochemistry. 109: 838-45. PMID 19250335 DOI: 10.1111/J.1471-4159.2009.06010.X  1
2008 McFarland NR, Schwarzschild MA. Is Mortality Increased with Essential Tremor Nejm Journal Watch. 2008. DOI: 10.1056/Jn200803110000003  1
2006 McFarland NR, Login IS, Vernon S, Burns TM. Improvement with corticosteroids and azathioprine in GAD65-associated cerebellar ataxia. Neurology. 67: 1308-9. PMID 17030779 DOI: 10.1212/01.Wnl.0000238389.83574.Be  1
2002 McFarland NR, Haber SN. Thalamic relay nuclei of the basal ganglia form both reciprocal and nonreciprocal cortical connections, linking multiple frontal cortical areas. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 8117-32. PMID 12223566 DOI: 10.1523/Jneurosci.22-18-08117.2002  1
2001 Haber S, McFarland NR. The place of the thalamus in frontal cortical-basal ganglia circuits. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 7: 315-24. PMID 11488397 DOI: 10.1177/107385840100700408  1
2001 McFarland NR, Haber SN. Organization of thalamostriatal terminals from the ventral motor nuclei in the macaque. The Journal of Comparative Neurology. 429: 321-36. PMID 11116223 DOI: 10.1002/1096-9861(20000108)429:2<321::Aid-Cne11>3.0.Co;2-A  1
2000 McFarland NR, Haber SN. Convergent inputs from thalamic motor nuclei and frontal cortical areas to the dorsal striatum in the primate. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 3798-813. PMID 10804220 DOI: 10.1523/Jneurosci.20-10-03798.2000  1
2000 Haber SN, Fudge JL, McFarland NR. Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatum. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 2369-82. PMID 10704511 DOI: 10.1523/Jneurosci.20-06-02369.2000  1
1999 Haber SN, McFarland NR. The concept of the ventral striatum in nonhuman primates. Annals of the New York Academy of Sciences. 877: 33-48. PMID 10415641 DOI: 10.1111/J.1749-6632.1999.Tb09259.X  1
1997 Chikama M, McFarland NR, Amaral DG, Haber SN. Insular cortical projections to functional regions of the striatum correlate with cortical cytoarchitectonic organization in the primate. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 9686-705. PMID 9391023 DOI: 10.1523/Jneurosci.17-24-09686.1997  1
1995 Giménez-Amaya JM, McFarland NR, de las Heras S, Haber SN. Organization of thalamic projections to the ventral striatum in the primate. The Journal of Comparative Neurology. 354: 127-49. PMID 7542290 DOI: 10.1002/Cne.903540109  1
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