Ken A. Witt, Ph.D. - Publications

Affiliations: 
University of Arizona, Tucson, AZ 
Area:
blood-brain barrier, drug delivery

60 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Neumann WL, Sandoval KE, Mobayen S, Minaeian M, Kukielski SG, Srabony KN, Frare R, Slater O, Farr SA, Niehoff ML, Hospital A, Kontoyianni M, Crider AM, Witt KA. Synthesis and structure-activity relationships of 3,4,5-trisubstituted-1,2,4-triazoles: high affinity and selective somatostatin receptor-4 agonists for Alzheimer's disease treatment. Rsc Medicinal Chemistry. 12: 1352-1365. PMID 34458738 DOI: 10.1039/d1md00044f  1
2020 Reeb C, Sandoval K, Wooten J, Harris M, Schaller M, House A, Witt KA. Dietary Dependent Alteration of Blood‐Brain Barrier Tight Junctional Protein Expression The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.05849  0.01
2019 Sandoval K, Umbaugh D, House A, Crider A, Witt K. Somatostatin Receptor Subtype-4 Regulates mRNA Expression of Amyloid-Beta Degrading Enzymes and Microglia Mediators of Phagocytosis in Brains of 3xTg-AD Mice. Neurochemical Research. PMID 31630317 DOI: 10.1007/S11064-019-02890-6  1
2019 Polina J, Walters F, Sandoval K, Crider AM, Witt K, Schober J. Somatostatin Receptor Subtype‐4 Agonist Increases Microglia Amyloid‐beta 1‐42 Uptake The Faseb Journal. 33. DOI: 10.1096/fasebj.2019.33.1_supplement.806.6  0.01
2018 Daryaei I, Sandoval K, Witt K, Kontoyianni M, Michael Crider A. Discovery of a 3,4,5-trisubstituted-1,2,4-triazole agonist with high affinity and selectivity at the somatostatin subtype-4 (sst) receptor. Medchemcomm. 9: 2083-2090. PMID 30746066 DOI: 10.1039/C8Md00388B  1
2018 Sandoval KE, Wooten JS, Harris MP, Schaller ML, Umbaugh DS, Witt KA. Mfsd2a and Glut1 Brain Nutrient Transporters Expression Increase with 32-Week Low and High Lard Compared with Fish-Oil Dietary Treatment in C57Bl/6 Mice. Current Developments in Nutrition. 2: nzy065. PMID 30338310 DOI: 10.1093/cdn/nzy065  1
2017 Harris MP, Schaller ML, Umbaugh D, Sandoval K, Witt KA, Wooten JS. The Effect of a Western Diet on Hepatic Autophagy in Age Accelerated SAMP8 Mice: 3588 Board #35 June 3 8 Medicine and Science in Sports and Exercise. 49: 1022. DOI: 10.1249/01.Mss.0000519803.45089.0F  1
2017 Maciejewski JC, Harris MP, Schaller ML, Umbaugh DS, Sandoval KE, Witt KA, Wooten JS, Guilford BL. Omega-3-Fatty Acids Hold Therapeutic Potential for the Prevention and Treatment of Diabetic Neuropathy Medicine & Science in Sports & Exercise. 49: 1018. DOI: 10.1249/01.Mss.0000519793.05185.50  0.01
2016 Farr SA, Sandoval KE, Niehoff ML, Witt KA, Kumar VB, Morley JE. Peripheral Administration of GSK-3β Antisense Oligonucleotide Improves Learning and Memory in SAMP8 and Tg2576 Mouse Models of Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 27589526 DOI: 10.3233/Jad-160416  1
2015 Sandoval KE, Witt KA, Michael Crider A, Kontoyianni M. Somatostatin receptor-4 agonists as candidates for treatment of alzheimer's disease Drug Design and Discovery in Alzheimer's Disease. 566-597. DOI: 10.1016/B978-0-12-803959-5.50012-X  1
2014 Witt KA, Sandoval KE. Steroids and the blood-brain barrier: therapeutic implications. Advances in Pharmacology (San Diego, Calif.). 71: 361-90. PMID 25307223 DOI: 10.1016/Bs.Apha.2014.06.018  1
2013 Sandoval KE, Farr SA, Banks WA, Crider AM, Morley JE, Witt KA. Somatostatin receptor subtype-4 agonist NNC 26-9100 mitigates the effect of soluble Aβ(42) oligomers via a metalloproteinase-dependent mechanism. Brain Research. 1520: 145-56. PMID 23669069 DOI: 10.1016/J.Brainres.2013.05.006  1
2013 Egleton RD, Witt KA, Davis TP. Opioid Peptides Handbook of Biologically Active Peptides. 1696-1701. DOI: 10.1016/B978-0-12-385095-9.00232-3  1
2013 Schorn D, Witt KA, Steinbeck J. Fractures of the acromion and the Spina scapulae following implantation of an inverse total endoprosthesis of the shoulder | Akromion- und Spina-scapulae-Frakturen nach Implantation einer inversen Schultertotalendoprothese Obere Extremitat. 8: 87-91. DOI: 10.1007/s11678-013-0213-5  1
2012 Sandoval KE, Farr SA, Banks WA, Crider AM, Morley JE, Witt KA. Somatostatin receptor subtype-4 agonist NNC 26-9100 decreases extracellular and intracellular Aβ₁₋₄₂ trimers. European Journal of Pharmacology. 683: 116-24. PMID 22449380 DOI: 10.1016/J.Ejphar.2012.03.020  1
2012 Wang X, Mealer D, Rodgers L, Sandoval K, Witt K, Stidsen C, Ankersen M, Crider AM. Synthesis of 2-thiohydantoins as somatostatin subtype 4 receptor ligands Letters in Drug Design and Discovery. 9: 655-662. DOI: 10.2174/157018012801319445  1
2012 Witt K, Farr S, Crider A, Sandoval K. P1-226: Somatostatin receptor subtype-4 agonist mitigates beta-amyloid oligomer expression in APPswe-mouse cortical tissue Alzheimer's & Dementia. 8: P186-P186. DOI: 10.1016/J.Jalz.2012.05.505  0.01
2011 Sandoval KE, Witt KA. Age and 17β-estradiol effects on blood-brain barrier tight junction and estrogen receptor proteins in ovariectomized rats. Microvascular Research. 81: 198-205. PMID 21192956 DOI: 10.1016/J.Mvr.2010.12.007  1
2011 Sandoval KE, Farr SA, Banks WA, Niehoff ML, Morley JE, Crider AM, Witt KA. Chronic peripheral administration of somatostatin receptor subtype-4 agonist NNC 26-9100 enhances learning and memory in SAMP8 mice. European Journal of Pharmacology. 654: 53-9. PMID 21185826 DOI: 10.1016/J.Ejphar.2010.12.013  1
2010 Witt KA, Ronaldson PT, Sandoval KE, Davis TP. CNS delivery of peptides across the bbb using the dual-artery in situ brain perfusion model Neuromethods. 45: 233-247. DOI: 10.1007/978-1-60761-529-3_11  1
2009 Steinbeck J, Witt KA, Marquardt B. [Arthroscopic versus open anterior shoulder stabilization. A systematic validation]. Der OrthopäDe. 38: 36-40. PMID 19093098 DOI: 10.1007/s00132-008-1353-y  1
2008 Sandoval KE, Witt KA. Blood-brain barrier tight junction permeability and ischemic stroke. Neurobiology of Disease. 32: 200-19. PMID 18790057 DOI: 10.1016/J.Nbd.2008.08.005  1
2008 Witt KA, Mark KS, Sandoval KE, Davis TP. Reoxygenation stress on blood-brain barrier paracellular permeability and edema in the rat. Microvascular Research. 75: 91-6. PMID 17651765 DOI: 10.1016/J.Mvr.2007.06.004  1
2007 Marquardt B, Garmann S, Schulte T, Witt KA, Steinbeck J, Pötzl W. Outcome after failed traumatic anterior shoulder instability repair with and without surgical revision. Journal of Shoulder and Elbow Surgery / American Shoulder and Elbow Surgeons ... [Et Al.]. 16: 742-7. PMID 17967548 DOI: 10.1016/j.jse.2007.02.132  1
2007 Liem D, Marquardt B, Witt KA, Steinbeck J. [Shoulder arthroplasty: biomechanics and design]. Der OrthopäDe. 36: 1027-36. PMID 17962920 DOI: 10.1007/s00132-007-1156-6  1
2007 Crider AM, Witt KA. Somatostatin sst4 ligands: chemistry and pharmacology. Mini Reviews in Medicinal Chemistry. 7: 213-20. PMID 17346214 DOI: 10.2174/138955707780059880  1
2007 Marquardt B, Witt KA, Steinbeck J. Painful shoulders. Diagnosis and therapy | Die schmerzhafte Schulter. Diagnostik und therapie Chirurgische Praxis. 67: 37-47.  1
2007 Marquardt B, Witt KA, Steinbeck J. Painful shoulders. Diagnosis and therapy | Die schmerzhafte Schulter. Diagnostik und therapie Chirurgische Praxis. 67: 37-47.  1
2007 Marquardt B, Witt KA, Steinbeck J. Painful shoulders. Diagnosis and therapy | Die schmerzhafte schulter: Diagnostik und therapie Tagliche Praxis. 48: 97-107.  1
2006 Marquardt B, Witt KA, Liem D, Steinbeck J, Pötzl W. Arthroscopic Bankart repair in traumatic anterior shoulder instability using a suture anchor technique. Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association. 22: 931-6. PMID 16952720 DOI: 10.1016/j.arthro.2006.04.105  1
2006 Marquardt B, Witt KA, Götze C, Liem D, Steinbeck J, Pötzl W. Long-term results of arthroscopic Bankart repair with a bioabsorbable tack. The American Journal of Sports Medicine. 34: 1906-10. PMID 16902234 DOI: 10.1177/0363546506290404  1
2006 Marquardt B, Hurschler C, Schneppendahl J, Witt KA, Pötzl W, Steinbeck J. Quantitative assessment of glenohumeral translation after anterior shoulder dislocation and subsequent arthroscopic bankart repair. The American Journal of Sports Medicine. 34: 1756-62. PMID 16840776 DOI: 10.1177/0363546506289702  1
2006 Marquardt B, Garmann S, Hurschler C, Pötzl W, Steens W, Witt KA, Steinbeck J. The influence of arthroscopic subscapularis tendon and anterior capsular release on glenohumeral translation: a biomechanical model. Journal of Shoulder and Elbow Surgery / American Shoulder and Elbow Surgeons ... [Et Al.]. 15: 502-8. PMID 16831658 DOI: 10.1016/j.jse.2005.09.018  1
2006 Witt KA, Davis TP. CNS drug delivery: opioid peptides and the blood-brain barrier. The Aaps Journal. 8: E76-88. PMID 16584136 DOI: 10.1208/Aapsj080109  1
2006 Liljenqvist U, Witt KA, Bullmann V, Steinbeck J, Völker K. [Recommendations on sport activities for patients with idiopathic scoliosis]. Sportverletzung Sportschaden : Organ Der Gesellschaft FüR OrthopäDisch-Traumatologische Sportmedizin. 20: 36-42. PMID 16544215 DOI: 10.1055/s-2005-859029  1
2006 Witt KA, Farr SA, Sandoval KE. P2-052: SELECTIVE SOMATOSTATIN RECEPTOR SUBTYPE-4 AGONISTS FOR ALZHEIMER'S DISEASE TREATMENT Alzheimer's & Dementia. 14: P686-P686. DOI: 10.1016/J.Jalz.2018.06.737  0.01
2006 Sandoval KE, Umbaugh DS, Witt KA. P2-051: INCREASED BRAIN MRNA EXPRESSION OF BETA AMYLOID DEGRADING ENZYMES WITH SOMATOSTATIN-4 RECEPTOR AGONIST TREATMENT IN 3XTG MICE Alzheimer's & Dementia. 14: P686-P686. DOI: 10.1016/J.Jalz.2018.06.736  0.01
2006 Egleton RD, Witt KA, Davis TP. Opiate Peptides And The Blood-Brain Barrier Handbook of Biologically Active Peptides. 1429-1434. DOI: 10.1016/B978-012369442-3/50202-6  1
2005 Marquardt B, Pötzl W, Witt KA, Steinbeck J. A modified capsular shift for atraumatic anterior-inferior shoulder instability. The American Journal of Sports Medicine. 33: 1011-5. PMID 15983123 DOI: 10.1177/0363546504272685  1
2005 Witt KA, Bush EA. College athletes with an elevated body mass index often have a high upper arm muscle area, but not elevated triceps and subscapular skinfolds. Journal of the American Dietetic Association. 105: 599-602. PMID 15800563 DOI: 10.1016/j.jada.2005.01.008  1
2005 Witt KA, Mark KS, Huber J, Davis TP. Hypoxia-inducible factor and nuclear factor kappa-B activation in blood-brain barrier endothelium under hypoxic/reoxygenation stress. Journal of Neurochemistry. 92: 203-14. PMID 15606909 DOI: 10.1111/J.1471-4159.2004.02871.X  1
2003 Pötzl W, Witt KA, Hackenberg L, Marquardt B, Steinbeck J. Results of suture anchor repair of anteroinferior shoulder instability: a prospective clinical study of 85 shoulders. Journal of Shoulder and Elbow Surgery / American Shoulder and Elbow Surgeons ... [Et Al.]. 12: 322-6. PMID 12934023 DOI: 10.1016/mse.2003.S1058274603000326  1
2003 Witt KA, Mark KS, Hom S, Davis TP. Effects of hypoxia-reoxygenation on rat blood-brain barrier permeability and tight junctional protein expression. American Journal of Physiology. Heart and Circulatory Physiology. 285: H2820-31. PMID 12907427 DOI: 10.1152/Ajpheart.00589.2003  1
2003 Huber JD, Campos CR, Egleton RD, Witt K, Guo L, Roberts MJ, Bentley MD, Davis TP. Conjugation of low molecular weight poly(ethylene glycol) to biphalin enhances antinociceptive profile. Journal of Pharmaceutical Sciences. 92: 1377-85. PMID 12820142 DOI: 10.1002/Jps.10406  1
2003 Pötzl W, Witt KA, Hackenberg L, Heusner T, Steinbeck J. Influence of postoperative immobilization on tendon length after radiofrequency-induced shrinkage. An in vivo rabbit study. The American Journal of Sports Medicine. 31: 36-40. PMID 12531754  1
2003 Egleton RD, Witt KA, Davis TP. Peptides and the Blood-Brain Barrier: Enhancing Peptide Bioavailability to the Brain Blood-Spinal Cord and Brain Barriers in Health and Disease. 107-115. DOI: 10.1016/B978-012639011-7/50015-2  1
2003 Pötzl W, Witt KA, Götze C, Garmann S, Steinbeck J, Winkelmann W. Acromioclavicular joint injuries. Diagnosis and treatment | Schultereckgelenkverletzungen. Diagnostik und therapie Chirurgische Praxis. 61: 267-277.  1
2002 Witt KA, Huber JD, Egleton RD, Davis TP. Pluronic p85 block copolymer enhances opioid peptide analgesia. The Journal of Pharmacology and Experimental Therapeutics. 303: 760-7. PMID 12388663 DOI: 10.1124/Jpet.102.039545  1
2002 Steinbeck J, Schneider M, Pötzl W, Witt KA, Liljenqvist U. [Comparison of the results of the surgical repair of full-thickness tears of the rotator cuff with and without resection of the lateral clavicle]. Zeitschrift FüR OrthopäDie Und Ihre Grenzgebiete. 140: 385-9. PMID 12183786 DOI: 10.1055/s-2002-33392  1
2001 Witt KA, Gillespie TJ, Huber JD, Egleton RD, Davis TP. Peptide drug modifications to enhance bioavailability and blood-brain barrier permeability. Peptides. 22: 2329-43. PMID 11786210 DOI: 10.1016/S0196-9781(01)00537-X  1
2001 Witt KA, Huber JD, Egleton RD, Roberts MJ, Bentley MD, Guo L, Wei H, Yamamura HI, Davis TP. Pharmacodynamic and pharmacokinetic characterization of poly(ethylene glycol) conjugation to met-enkephalin analog [D-Pen2, D-Pen5]-enkephalin (DPDPE). The Journal of Pharmacology and Experimental Therapeutics. 298: 848-56. PMID 11454951  1
2001 Huber JD, Witt KA, Hom S, Egleton RD, Mark KS, Davis TP. Inflammatory pain alters blood-brain barrier permeability and tight junctional protein expression. American Journal of Physiology. Heart and Circulatory Physiology. 280: H1241-8. PMID 11179069 DOI: 10.1152/Ajpheart.2001.280.3.H1241  1
2001 Pötzl W, Witt KA, Steinbeck J. Unstable shoulder. Diagnosis and therapy Chirurgische Praxis. 58: 559-570.  1
2000 Witt KA, Huber JD, Egleton RD, Davis TP. Insulin enhancement of opioid peptide transport across the blood-brain barrier and assessment of analgesic effect. The Journal of Pharmacology and Experimental Therapeutics. 295: 972-8. PMID 11082431  1
2000 Witt KA, Slate CA, Egleton RD, Huber JD, Yamamura HI, Hruby VJ, Davis TP. Assessment of stereoselectivity of trimethylphenylalanine analogues of delta-opioid [D-Pen(2),D-Pen(5)]-enkephalin. Journal of Neurochemistry. 75: 424-35. PMID 10854288 DOI: 10.1046/J.1471-4159.2000.0750424.X  1
1993 Witt KA, Snook JT, O'Dorisio TM, Zivony D, Malarkey WB. Exercise training and dietary carbohydrate: effects on selected hormones and the thermic effect of feeding. International Journal of Sport Nutrition. 3: 272-89. PMID 8220393 DOI: 10.1123/Ijsn.3.3.272  1
1991 Sommer A, Katz J, Quigley HA, Miller NR, Robin AL, Richter RC, Witt KA. Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss. Archives of Ophthalmology (Chicago, Ill. : 1960). 109: 77-83. PMID 1987954  0.01
1991 Sommer A, Tielsch JM, Katz J, Quigley HA, Gottsch JD, Javitt JC, Martone JF, Royall RM, Witt KA, Ezrine S. Racial differences in the cause-specific prevalence of blindness in east Baltimore. The New England Journal of Medicine. 325: 1412-7. PMID 1922252 DOI: 10.1056/Nejm199111143252004  1
1975 Veale DR, Smith H, Witt KA, Marshall RB. Differential ability of colonial types of Neisseria gonorrhoeae to produce infection cutaneous perforated plastic chambers in guinea-pigs and rabbits. Journal of Medical Microbiology. 8: 325-35. PMID 806688 DOI: 10.1099/00222615-8-2-325  0.01
1966 Keppie J, Witt KA, Smith H. Early appearance of colonies of Brucella spp. on solid media containing erythritol. The Journal of Applied Bacteriology. 29: 556-8. PMID 5980919  0.01
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