Alexander R. McCampbell, Ph.D. - Publications

Institution:
University of Pennsylvania, Philadelphia, PA, United States

9/41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Cook CN, Wu Y, Odeh HM, Gendron TF, Jansen-West K, Del Rosso G, Yue M, Jiang P, Gomes E, Tong J, Daughrity LM, Avendano NM, Castanedes-Casey M, Shao W, Oskarsson B, ... ... McCampbell A, et al. poly(GR) aggregation induces TDP-43 proteinopathy. Science Translational Medicine. 12. PMID 32878979 DOI: 10.1126/Scitranslmed.Abb3774  0.397
2019 Zhang YJ, Guo L, Gonzales PK, Gendron TF, Wu Y, Jansen-West K, O'Raw AD, Pickles SR, Prudencio M, Carlomagno Y, Gachechiladze MA, Ludwig C, Tian R, Chew J, DeTure M, ... ... McCampbell A, et al. Heterochromatin anomalies and double-stranded RNA accumulation underlie poly(PR) toxicity. Science (New York, N.Y.). 363. PMID 30765536 DOI: 10.1126/Science.Aav2606  0.361
2017 Sweeney P, Park H, Baumann M, Dunlop J, Frydman J, Kopito R, McCampbell A, Leblanc G, Venkateswaran A, Nurmi A, Hodgson R. Protein misfolding in neurodegenerative diseases: implications and strategies. Translational Neurodegeneration. 6: 6. PMID 28293421 DOI: 10.1186/S40035-017-0077-5  0.363
2015 Periz G, Lu J, Zhang T, Kankel MW, Jablonski AM, Kalb R, McCampbell A, Wang J. Regulation of protein quality control by UBE4B and LSD1 through p53-mediated transcription. Plos Biology. 13: e1002114. PMID 25837623 DOI: 10.1371/Journal.Pbio.1002114  0.362
2009 Ma L, Seager MA, Seager M, Wittmann M, Jacobson M, Bickel D, Burno M, Jones K, Graufelds VK, Xu G, Pearson M, McCampbell A, Gaspar R, Shughrue P, Danziger A, et al. Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation. Proceedings of the National Academy of Sciences of the United States of America. 106: 15950-5. PMID 19717450 DOI: 10.1073/Pnas.0900903106  0.306
2001 McCampbell A, Taye AA, Whitty L, Penney E, Steffan JS, Fischbeck KH. Histone deacetylase inhibitors reduce polyglutamine toxicity. Proceedings of the National Academy of Sciences of the United States of America. 98: 15179-84. PMID 11742087 DOI: 10.1073/Pnas.261400698  0.608
2001 Steffan JS, Bodai L, Pallos J, Poelman M, McCampbell A, Apostol BL, Kazantsev A, Schmidt E, Zhu YZ, Greenwald M, Kurokawa R, Housman DE, Jackson GR, Marsh JL, Thompson LM. Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila. Nature. 413: 739-43. PMID 11607033 DOI: 10.1038/35099568  0.566
2001 McCampbell A, Fischbeck KH. Polyglutamine and CBP: fatal attraction? Nature Medicine. 7: 528-30. PMID 11329046 DOI: 10.1038/87842  0.551
2000 McCampbell A, Taylor JP, Taye AA, Robitschek J, Li M, Walcott J, Merry D, Chai Y, Paulson H, Sobue G, Fischbeck KH. CREB-binding protein sequestration by expanded polyglutamine. Human Molecular Genetics. 9: 2197-202. PMID 10958659 DOI: 10.1093/Hmg/9.14.2197  0.498
Low-probability matches (unlikely to be authored by this person)
2017 Gendron TF, Chew J, Stankowski JN, Hayes LR, Zhang YJ, Prudencio M, Carlomagno Y, Daughrity LM, Jansen-West K, Perkerson EA, O'Raw A, Cook C, Pregent L, Belzil V, van Blitterswijk M, ... ... McCampbell A, et al. Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis. Science Translational Medicine. 9. PMID 28356511 DOI: 10.1126/Scitranslmed.Aai7866  0.281
2015 Staropoli JF, Li H, Chun SJ, Allaire N, Cullen P, Thai A, Fleet CM, Hua Y, Bennett CF, Krainer AR, Kerr D, McCampbell A, Rigo F, Carulli JP. Rescue of gene-expression changes in an induced mouse model of spinal muscular atrophy by an antisense oligonucleotide that promotes inclusion of SMN2 exon 7. Genomics. 105: 220-8. PMID 25645699 DOI: 10.1016/J.Ygeno.2015.01.007  0.278
2005 McCampbell A, Truong D, Broom DC, Allchorne A, Gable K, Cutler RG, Mattson MP, Woolf CJ, Frosch MP, Harmon JM, Dunn TM, Brown RH. Mutant SPTLC1 dominantly inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy. Human Molecular Genetics. 14: 3507-21. PMID 16210380 DOI: 10.1093/Hmg/Ddi380  0.272
2021 Torregrosa T, Lehman S, Hana S, Marsh G, Xu S, Koszka K, Mastrangelo N, McCampbell A, Henderson CE, Lo SC. Use of CRISPR/Cas9-mediated disruption of CNS cell type genes to profile transduction of AAV by neonatal intracerebroventricular delivery in mice. Gene Therapy. PMID 33612827 DOI: 10.1038/s41434-021-00223-3  0.263
2014 Savage MJ, Kalinina J, Wolfe A, Tugusheva K, Korn R, Cash-Mason T, Maxwell JW, Hatcher NG, Haugabook SJ, Wu G, Howell BJ, Renger JJ, Shughrue PJ, McCampbell A. A sensitive aβ oligomer assay discriminates Alzheimer's and aged control cerebrospinal fluid. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 2884-97. PMID 24553930 DOI: 10.1523/Jneurosci.1675-13.2014  0.258
2018 Ling KK, Jackson M, Alkam D, Liu D, Allaire N, Sun C, Kiaei M, McCampbell A, Rigo F. Antisense-mediated reduction of EphA4 in the adult CNS does not improve the function of mice with amyotrophic lateral sclerosis. Neurobiology of Disease. PMID 29518482 DOI: 10.1016/j.nbd.2018.03.002  0.25
2018 Selvaraj BT, Livesey MR, Zhao C, Gregory JM, James OT, Cleary EM, Chouhan AK, Gane AB, Perkins EM, Dando O, Lillico SG, Lee YB, Nishimura AL, Poreci U, Thankamony S, ... ... McCampbell A, et al. C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity. Nature Communications. 9: 347. PMID 29367641 DOI: 10.1038/S41467-017-02729-0  0.246
2022 Chen YA, Kankel MW, Hana S, Lau SK, Zavodszky MI, McKissick O, Mastrangelo N, Dion J, Wang B, Ferretti D, Koske D, Lehman S, Koszka K, McLaughlin H, Liu M, ... ... McCampbell A, et al. In vivo genome editing using novel AAV-PHP variants rescues motor function deficits and extends survival in a SOD1-ALS mouse model. Gene Therapy. 1-12. PMID 36450833 DOI: 10.1038/s41434-022-00375-w  0.237
2021 Fumagalli L, Young FL, Boeynaems S, De Decker M, Mehta AR, Swijsen A, Fazal R, Guo W, Moisse M, Beckers J, Dedeene L, Selvaraj BT, Vandoorne T, Madan V, van Blitterswijk M, ... ... McCampbell A, et al. -derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility. Science Advances. 7. PMID 33837088 DOI: 10.1126/sciadv.abg3013  0.232
2009 Eichler FS, Hornemann T, McCampbell A, Kuljis D, Penno A, Vardeh D, Tamrazian E, Garofalo K, Lee HJ, Kini L, Selig M, Frosch M, Gable K, von Eckardstein A, Woolf CJ, et al. Overexpression of the wild-type SPT1 subunit lowers desoxysphingolipid levels and rescues the phenotype of HSAN1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 14646-51. PMID 19923297 DOI: 10.1523/Jneurosci.2536-09.2009  0.221
2018 McCampbell A, Cole T, Wegener AJ, Tomassy GS, Setnicka A, Farley BJ, Schoch KM, Hoye ML, Shabsovich M, Sun L, Luo Y, Zhang M, Thankamony S, Salzman DW, Cudkowicz M, et al. Antisense oligonucleotides extend survival and reverse decrement in muscle response in ALS models. The Journal of Clinical Investigation. PMID 30010620 DOI: 10.1172/Jci99081  0.216
2011 McCampbell A, Wessner K, Marlatt MW, Wolffe C, Toolan D, Podtelezhnikov A, Yeh S, Zhang R, Szczerba P, Tanis KQ, Majercak J, Ray WJ, Savage M. Induction of Alzheimer's-like changes in brain of mice expressing mutant APP fed excess methionine. Journal of Neurochemistry. 116: 82-92. PMID 21054384 DOI: 10.1111/J.1471-4159.2010.07087.X  0.211
2022 Paris A, Bora P, Parolo S, Monine M, Tong X, Eraly S, Masson E, Ferguson T, McCampbell A, Graham D, Domenici E, Nestorov I, Marchetti L. An Age Dependent Mathematical Model of Neurofilament Trafficking in Healthy Conditions. Cpt: Pharmacometrics & Systems Pharmacology. PMID 35146969 DOI: 10.1002/psp4.12770  0.21
2014 Converso A, Hartingh T, Fraley ME, Garbaccio RM, Hartman GD, Huang SY, Majercak JM, McCampbell A, Na SJ, Ray WJ, Savage MJ, Wolffe C, Yeh S, Yu Y, White R, et al. Adenosine analogue inhibitors of S-adenosylhomocysteine hydrolase. Bioorganic & Medicinal Chemistry Letters. 24: 2737-40. PMID 24813734 DOI: 10.1016/J.Bmcl.2014.04.034  0.196
2008 Savage MJ, McCampbell AR, Wessner K, Na S, Marlatt M, Bickel D, Burno M, Jones K, Kuzmick-Graufelds V, Yeh S, Zhang R, White R, Seager M, Majercak J, Ray WJ. P1-016: Dietary induction of hyperhomocystemia and the impact on Alzheimer's disease-relevant markers Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.601  0.191
2012 Wolfe A, McCampbell A, Hatcher N, Tugusheva K, Haugabook S, Maxwell J, Wu G, Howell B, Renger J, Shughrue P, Savage M. P2-043: A quantitative assay selective for amyloid oligomer species differentiates cerebrospinal fluid from Alzheimer's disease and age-matched normal Alzheimer's & Dementia. 8: P278-P278. DOI: 10.1016/j.jalz.2012.05.746  0.189
2011 Zhao WQ, Toolan D, Hepler RW, Wolfe AL, Yu Y, Price E, Uebele VN, Schachter JB, Reynolds IJ, Renger JJ, McCampbell A, Ray WJ. High throughput monitoring of amyloid-β(42) assembly into soluble oligomers achieved by sensitive conformation state-dependent immunoassays. Journal of Alzheimer's Disease : Jad. 25: 655-69. PMID 21483096 DOI: 10.3233/Jad-2011-102022  0.177
2020 Kankel MW, Sen A, Lu L, Theodorou M, Dimlich DN, McCampbell A, Henderson CE, Shneider NA, Artavanis-Tsakonas S. Amyotrophic Lateral Sclerosis Modifiers in Reveal the Phospholipase D Pathway as a Potential Therapeutic Target. Genetics. PMID 32345615 DOI: 10.1534/Genetics.119.302985  0.177
2020 Miller T, Cudkowicz M, Shaw PJ, Andersen PM, Atassi N, Bucelli RC, Genge A, Glass J, Ladha S, Ludolph AL, Maragakis NJ, McDermott CJ, Pestronk A, Ravits J, Salachas F, ... ... McCampbell A, et al. Phase 1-2 Trial of Antisense Oligonucleotide Tofersen for ALS. The New England Journal of Medicine. 383: 109-119. PMID 32640130 DOI: 10.1056/Nejmoa2003715  0.15
2005 Dionne A, Brunet D, McCampbell A, Dupré N. Adrenomyeloneuropathy: report of a new mutation in a French Canadian female. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 32: 261-3. PMID 16018167 DOI: 10.1017/S0317167100004091  0.135
2013 Yang X, Xu W, Dukleska S, Benchaar S, Mengisen S, Antochshuk V, Cheung J, Mann L, Babadjanova Z, Rowand J, Gunawan R, McCampbell A, Beaumont M, Meininger D, Richardson D, et al. Developability studies before initiation of process development: improving manufacturability of monoclonal antibodies. Mabs. 5: 787-94. PMID 23883920 DOI: 10.4161/Mabs.25269  0.13
2019 Cammack AJ, Atassi N, Hyman T, van den Berg LH, Harms M, Baloh RH, Brown RH, van Es MA, Veldink JH, de Vries BS, Rothstein JD, Drain C, Jockel-Balsarotti J, Malcolm A, Boodram S, ... ... McCampbell A, et al. Prospective natural history study of ALS clinical characteristics and biomarkers. Neurology. PMID 31578300 DOI: 10.1212/Wnl.0000000000008359  0.123
2008 McCampbell A, Seager M, Zerbinatti C, Nunes I, Savage MJ, Meziane H, Rosahl T. P1-037: Presence of an anxiety phenotype in APOE-KO and YAC-APP/APOE-KO mice Alzheimer's & Dementia. 4: T216-T216. DOI: 10.1016/j.jalz.2008.05.622  0.113
2010 McCampbell A, Wessner K, Toolan D, Podtelezhnikov A, Majercak J, Tanis KQ, Ray WJ, Savage MJ. High methionine diet induces beta-amyloid–related transcriptional changes in mouse brain Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.669  0.104
1997 Dornan WA, McCampbell AR, Tinkler GP, Hickman LJ, Bannon AW, Decker MW, Gunther KL. Comparison of site specific injections into the basal forebrain on water maze and radial arm maze performance in the male rat after immunolesioning with 192 IgG saporin. Behavioural Brain Research. 86: 181-9. PMID 9134153 DOI: 10.1016/S0166-4328(96)02264-4  0.089
1996 Dornan WA, McCampbell AR, Tinkler GP, Hickman LJ, Bannon AW, Decker MW, Gunther KL. Comparison of site-specific injections into the basal forebrain on water maze and radial arm maze performance in the male rat after immunolesioning with 192 IgG saporin. Behavioural Brain Research. 82: 93-101. PMID 9021074 DOI: 10.1016/S0166-4328(97)81112-6  0.089
2011 Gotter AL, Santarelli VP, Doran SM, Tannenbaum PL, Kraus RL, Rosahl TW, Meziane H, Montial M, Reiss DR, Wessner K, McCampbell A, Stevens J, Brunner JI, Fox SV, Uebele VN, et al. TASK-3 as a potential antidepressant target. Brain Research. 1416: 69-79. PMID 21885038 DOI: 10.1016/J.Brainres.2011.08.021  0.076
2019 Darras BT, Crawford TO, Finkel RS, Mercuri E, De Vivo DC, Oskoui M, Tizzano EF, Ryan MM, Muntoni F, Zhao G, Staropoli J, McCampbell A, Petrillo M, Stebbins C, Fradette S, et al. Neurofilament as a potential biomarker for spinal muscular atrophy. Annals of Clinical and Translational Neurology. 6: 932-944. PMID 31139691 DOI: 10.1002/acn3.779  0.073
2019 Chen Y, Mazur C, Luo Y, Sun L, Zhang M, McCampbell A, Tomassy GS. Intrathecal Delivery of Antisense Oligonucleotides in the Rat Central Nervous System. Journal of Visualized Experiments : Jove. PMID 31736489 DOI: 10.3791/60274  0.072
1993 Dornan WA, Kang DE, McCampbell A, Kang EE. Bilateral injections of βA(25-35)+ IBO into the hippocampus disrupts acquisition of spatial learning in the rat Neuroreport. 5: 165-168. PMID 8111004 DOI: 10.1097/00001756-199311180-00018  0.064
2011 McCampbell A, Michener M, Smith B, Lennox C, Dancho M, Yeh S, Zhang R, Rajapaske H, Ray W, Reynolds I, Kornilova A. Peripheral and central responses of kynurenine pathway in response to low and high tryptophan-containing food in rhesus macaques Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.323  0.064
2010 Savage MJ, Wu G, McCampbell A, Wessner KR, Citron M, Liang X, Hsieh S, Wolfe AL, Kinney GG, Rosen LB, Renger JJ. O3-07-03: A novel multivalent Abeta peptide vaccine with preclinical evidence of a central immune response that generates antisera recognizing a wide range of Abeta peptide species Alzheimer's & Dementia. 6: S142-S142. DOI: 10.1016/j.jalz.2010.05.437  0.043
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