Gerald Crabtree - Publications

Stanford University, Palo Alto, CA 
 Howard Hughes Medical Institute, Chevy Chase, MD, United States 
Development, Signal Transduction, Molecular Neurobiology

136 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Chang CY, Shipony Z, Lin SG, Kuo A, Xiong X, Loh KM, Greenleaf WJ, Crabtree GR. Increased ACTL6A occupancy within mSWI/SNF chromatin remodelers drives human squamous cell carcinoma. Molecular Cell. PMID 34687603 DOI: 10.1016/j.molcel.2021.10.005  0.312
2021 Weber CM, Hafner A, Kirkland JG, Braun SMG, Stanton BZ, Boettiger AN, Crabtree GR. mSWI/SNF promotes Polycomb repression both directly and through genome-wide redistribution. Nature Structural & Molecular Biology. 28: 501-511. PMID 34117481 DOI: 10.1038/s41594-021-00604-7  0.775
2021 Braun SMG, Petrova R, Tang J, Krokhotin A, Miller EL, Tang Y, Panagiotakos G, Crabtree GR. BAF subunit switching regulates chromatin accessibility to control cell cycle exit in the developing mammalian cortex. Genes & Development. PMID 33602870 DOI: 10.1101/gad.342345.120  0.329
2021 Lo YH, Kolahi KS, Du Y, Chang CY, Krokhotin A, Nair A, Sobba WD, Karlsson K, Jones SJ, Longacre TA, Mah AT, Tercan B, Sockell A, Xu H, Seoane JA, ... ... Crabtree GR, et al. A CRISPR/Cas9-engineered ARID1A-deficient human gastric cancer organoid model reveals essential and non-essential modes of oncogenic transformation. Cancer Discovery. PMID 33451982 DOI: 10.1158/2159-8290.CD-20-1109  0.55
2020 Sood S, Weber CM, Hodges HC, Krokhotin A, Shalizi A, Crabtree GR. CHD8 dosage regulates transcription in pluripotency and early murine neural differentiation. Proceedings of the National Academy of Sciences of the United States of America. PMID 32839322 DOI: 10.1073/pnas.1921963117  0.799
2020 Chory EJ, Kirkland JG, Chang CY, D'Andrea VD, Gourisankar S, Dykhuizen EC, Crabtree GR. Chemical Inhibitors of a Selective SWI/SNF Function Synergize with ATR Inhibition in Cancer Cell Killing. Acs Chemical Biology. PMID 32369697 DOI: 10.1021/Acschembio.0C00312  0.782
2020 Wenderski W, Wang L, Krokhotin A, Walsh JJ, Li H, Shoji H, Ghosh S, George RD, Miller EL, Elias L, Gillespie MA, Son EY, Staahl BT, Baek ST, Stanley V, ... ... Crabtree GR, et al. Loss of the neural-specific BAF subunit ACTL6B relieves repression of early response genes and causes recessive autism. Proceedings of the National Academy of Sciences of the United States of America. PMID 32312822 DOI: 10.1073/Pnas.1908238117  0.782
2019 Seoane JA, Kirkland JG, Caswell-Jin JL, Crabtree GR, Curtis C. Chromatin regulators mediate anthracycline sensitivity in breast cancer. Nature Medicine. PMID 31700186 DOI: 10.1038/S41591-019-0638-5  0.728
2019 Chory EJ, Calarco JP, Hathaway NA, Bell O, Neel DS, Crabtree GR. Nucleosome Turnover Regulates Histone Methylation Patterns over the Genome. Molecular Cell. 73: 61-72.e3. PMID 30472189 DOI: 10.1016/J.Molcel.2018.10.028  0.755
2018 Marian CA, Stoszko M, Wang L, Leighty MW, de Crignis E, Maschinot CA, Gatchalian J, Carter BC, Chowdhury B, Hargreaves DC, Duvall JR, Crabtree GR, Mahmoudi T, Dykhuizen EC. Small Molecule Targeting of Specific BAF (mSWI/SNF) Complexes for HIV Latency Reversal. Cell Chemical Biology. PMID 30197195 DOI: 10.1016/J.Chembiol.2018.08.004  0.718
2018 Stanton BZ, Chory EJ, Crabtree GR. Chemically induced proximity in biology and medicine. Science (New York, N.Y.). 359. PMID 29590011 DOI: 10.1126/Science.Aao5902  0.774
2018 Hodges HC, Stanton BZ, Cermakova K, Chang CY, Miller EL, Kirkland JG, Ku WL, Veverka V, Zhao K, Crabtree GR. Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers. Nature Structural & Molecular Biology. 25: 61-72. PMID 29323272 DOI: 10.1038/s41594-017-0007-3  0.784
2017 Braun SMG, Kirkland JG, Chory EJ, Husmann D, Calarco JP, Crabtree GR. Rapid and reversible epigenome editing by endogenous chromatin regulators. Nature Communications. 8: 560. PMID 28916764 DOI: 10.1038/S41467-017-00644-Y  0.818
2017 Stanton BZ, Hodges C, Crabtree GR, Zhao K. A General Non-Radioactive ATPase Assay for Chromatin Remodeling Complexes. Current Protocols in Chemical Biology. 9: 1-10. PMID 28253434 DOI: 10.1002/Cpch.16  0.574
2017 Miller EL, Hargreaves DC, Kadoch C, Chang CY, Calarco JP, Hodges C, Buenrostro JD, Cui K, Greenleaf WJ, Zhao K, Crabtree GR. TOP2 synergizes with BAF chromatin remodeling for both resolution and formation of facultative heterochromatin. Nature Structural & Molecular Biology. PMID 28250416 DOI: 10.1038/Nsmb.3384  0.8
2016 Kadoch C, Williams RT, Calarco JP, Miller EL, Weber CM, Braun SM, Pulice JL, Chory EJ, Crabtree GR. Dynamics of BAF-Polycomb complex opposition on heterochromatin in normal and oncogenic states. Nature Genetics. PMID 27941796 DOI: 10.1038/Ng.3734  0.819
2016 Stanton BZ, Hodges C, Calarco JP, Braun SM, Ku WL, Kadoch C, Zhao K, Crabtree GR. Smarca4 ATPase mutations disrupt direct eviction of PRC1 from chromatin. Nature Genetics. PMID 27941795 DOI: 10.1038/Ng.3735  0.73
2016 Hodges C, Kirkland JG, Crabtree GR. The Many Roles of BAF (mSWI/SNF) and PBAF Complexes in Cancer. Cold Spring Harbor Perspectives in Medicine. PMID 27413115 DOI: 10.1101/Cshperspect.A026930  0.758
2016 Panamarova M, Cox A, Wicher K, Butler R, Bulgakova N, Jeon S, Rosen B, Seong RH, Skarnes W, Crabtree G, Zernicka-Goetz M. BAF chromatin remodelling complex is an epigenetic regulator of lineage specification in the early mouse embryo. Development (Cambridge, England). PMID 26952987 DOI: 10.1242/Dev.131961  0.451
2015 Kadoch C, Crabtree GR. Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics. Science Advances. 1: e1500447. PMID 26601204 DOI: 10.1126/Sciadv.1500447  0.644
2015 Zhan X, Cao M, Yoo AS, Zhang Z, Chen L, Crabtree GR, Wu JI. Generation of BAF53b-Cre transgenic mice with pan-neuronal Cre activities. Genesis (New York, N.Y. : 2000). 53: 440-8. PMID 26077106 DOI: 10.1002/Dvg.22866  0.661
2014 Buscarlet M, Krasteva V, Ho L, Simon C, Hébert J, Wilhelm B, Crabtree GR, Sauvageau G, Thibault P, Lessard JA. Essential role of BRG, the ATPase subunit of BAF chromatin remodeling complexes, in leukemia maintenance. Blood. 123: 1720-8. PMID 24478402 DOI: 10.1182/Blood-2013-02-483495  0.321
2014 Crabtree G. Abstract SY24-03: Chromatin regulation in cancer Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Sy24-03  0.417
2014 Buscarlet M, Krasteva V, Ho L, Simon C, Hebert J, Wilhelm B, Crabtree G, Sauvageau G, Thibault P, Lessard J. An exchange of alternative ATPases within BAF complexes accompanies the transition from hemopoietic stem cell quiescence to proliferation Experimental Hematology. 42: S4. DOI: 10.1016/J.Exphem.2014.07.013  0.321
2013 Staahl BT, Crabtree GR. Creating a neural specific chromatin landscape by npBAF and nBAF complexes. Current Opinion in Neurobiology. 23: 903-13. PMID 24090879 DOI: 10.1016/j.conb.2013.09.003  0.775
2013 Tang J, Yoo AS, Crabtree GR. Reprogramming human fibroblasts to neurons by recapitulating an essential microRNA-chromatin switch. Current Opinion in Genetics & Development. 23: 591-8. PMID 24035011 DOI: 10.1016/J.Gde.2013.07.001  0.649
2013 Ninkovic J, Steiner-Mezzadri A, Jawerka M, Akinci U, Masserdotti G, Petricca S, Fischer J, von Holst A, Beckers J, Lie CD, Petrik D, Miller E, Tang J, Wu J, Lefebvre V, ... ... Crabtree G, et al. The BAF complex interacts with Pax6 in adult neural progenitors to establish a neurogenic cross-regulatory transcriptional network. Cell Stem Cell. 13: 403-18. PMID 23933087 DOI: 10.1016/J.Stem.2013.07.002  0.492
2013 Staahl BT, Tang J, Wu W, Sun A, Gitler AD, Yoo AS, Crabtree GR. Kinetic analysis of npBAF to nBAF switching reveals exchange of SS18 with CREST and integration with neural developmental pathways. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 10348-61. PMID 23785148 DOI: 10.1523/Jneurosci.1258-13.2013  0.801
2013 Chesi A, Staahl BT, Jovičić A, Couthouis J, Fasolino M, Raphael AR, Yamazaki T, Elias L, Polak M, Kelly C, Williams KL, Fifita JA, Maragakis NJ, Nicholson GA, King OD, ... ... Crabtree GR, et al. Exome sequencing to identify de novo mutations in sporadic ALS trios. Nature Neuroscience. 16: 851-5. PMID 23708140 DOI: 10.1038/Nn.3412  0.78
2013 Dykhuizen EC, Hargreaves DC, Miller EL, Cui K, Korshunov A, Kool M, Pfister S, Cho YJ, Zhao K, Crabtree GR. BAF complexes facilitate decatenation of DNA by topoisomerase IIα. Nature. 497: 624-7. PMID 23698369 DOI: 10.1038/Nature12146  0.802
2013 Kadoch C, Hargreaves DC, Hodges C, Elias L, Ho L, Ranish J, Crabtree GR. Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy. Nature Genetics. 45: 592-601. PMID 23644491 DOI: 10.1038/Ng.2628  0.792
2013 Kadoch C, Crabtree GR. Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma. Cell. 153: 71-85. PMID 23540691 DOI: 10.1016/J.Cell.2013.02.036  0.627
2013 Vogel-Ciernia A, Matheos DP, Barrett RM, Kramár EA, Azzawi S, Chen Y, Magnan CN, Zeller M, Sylvain A, Haettig J, Jia Y, Tran A, Dang R, Post RJ, Chabrier M, ... ... Crabtree GR, et al. The neuron-specific chromatin regulatory subunit BAF53b is necessary for synaptic plasticity and memory. Nature Neuroscience. 16: 552-61. PMID 23525042 DOI: 10.1038/Nn.3359  0.4
2013 Bao X, Tang J, Lopez-Pajares V, Tao S, Qu K, Crabtree GR, Khavari PA. ACTL6a enforces the epidermal progenitor state by suppressing SWI/SNF-dependent induction of KLF4. Cell Stem Cell. 12: 193-203. PMID 23395444 DOI: 10.1016/J.Stem.2012.12.014  0.6
2013 Sun AX, Crabtree GR, Yoo AS. MicroRNAs: regulators of neuronal fate. Current Opinion in Cell Biology. 25: 215-21. PMID 23374323 DOI: 10.1016/J.Ceb.2012.12.007  0.651
2013 Kadoch C, Crabtree GR. Reversing the oncogenic roles of misdirected chromatin remodeling: Mechanistic insights into the SS18-SSX fusion protein in synovial sarcoma. Journal of Clinical Oncology. 31: 10515-10515. DOI: 10.1200/Jco.2013.31.15_Suppl.10515  0.636
2013 Dykhuizen E, Hargreaves D, Miller E, Cui K, Korshunov A, Kool M, Pfister S, Cho Y, Zhao K, Crabtree G. Abstract PR08: mSWI/SNF (BAF) complexes facilitate decatentation of DNA by topoisomerase IIα Cancer Research. 73. DOI: 10.1158/1538-7445.Cec13-Pr08  0.606
2012 Dykhuizen EC, Carmody LC, Tolliday N, Crabtree GR, Palmer MA. Screening for inhibitors of an essential chromatin remodeler in mouse embryonic stem cells by monitoring transcriptional regulation. Journal of Biomolecular Screening. 17: 1221-30. PMID 22853929 DOI: 10.1177/1087057112455060  0.339
2012 Weeraratne SD, Archer T, Pugh TJ, Hargreaves D, Yu F, Kautzman A, Jones DTW, Jaeger N, Tamayo P, Mesirov JP, Pfister SM, Lichter P, Crabtree G, Meyerson M, Pomeroy SL, et al. Abstract 1313: Mutually exclusive somatic mutations in WNT pathway medulloblastomas reveal a critical interaction between DDX3X and SMARCA4 Cancer Research. 72: 1313-1313. DOI: 10.1158/1538-7445.Am2012-1313  0.363
2011 Yoo AS, Sun AX, Li L, Shcheglovitov A, Portmann T, Li Y, Lee-Messer C, Dolmetsch RE, Tsien RW, Crabtree GR. MicroRNA-mediated conversion of human fibroblasts to neurons. Nature. 476: 228-31. PMID 21753754 DOI: 10.1038/Nature10323  0.605
2011 Hargreaves DC, Crabtree GR. ATP-dependent chromatin remodeling: genetics, genomics and mechanisms. Cell Research. 21: 396-420. PMID 21358755 DOI: 10.1038/cr.2011.32  0.767
2010 Shaw JP, Utz PJ, Durand DB, Toole JJ, Emmel EA, Crabtree GR. Identification of a putative regulator of early T cell activation genes. Science. 1988. 241: 202-205. Journal of Immunology (Baltimore, Md. : 1950). 185: 4972-5. PMID 20962265 DOI: 10.1126/Science.3260404  0.563
2010 Lessard JA, Crabtree GR. Chromatin regulatory mechanisms in pluripotency. Annual Review of Cell and Developmental Biology. 26: 503-32. PMID 20624054 DOI: 10.1146/annurev-cellbio-051809-102012  0.313
2009 Yoo AS, Staahl BT, Chen L, Crabtree GR. MicroRNA-mediated switching of chromatin-remodelling complexes in neural development. Nature. 460: 642-6. PMID 19561591 DOI: 10.1038/Nature08139  0.791
2009 Yoo AS, Crabtree GR. ATP-dependent chromatin remodeling in neural development. Current Opinion in Neurobiology. 19: 120-6. PMID 19442513 DOI: 10.1016/J.Conb.2009.04.006  0.671
2009 Ho L, Ronan JL, Wu J, Staahl BT, Chen L, Kuo A, Lessard J, Nesvizhskii AI, Ranish J, Crabtree GR. An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency. Proceedings of the National Academy of Sciences of the United States of America. 106: 5181-6. PMID 19279220 DOI: 10.1073/Pnas.0812889106  0.8
2009 Ho L, Jothi R, Ronan JL, Cui K, Zhao K, Crabtree GR. An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network. Proceedings of the National Academy of Sciences of the United States of America. 106: 5187-91. PMID 19279218 DOI: 10.1073/Pnas.0812888106  0.585
2009 Kao SC, Wu H, Xie J, Chang CP, Ranish JA, Graef IA, Crabtree GR. Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation. Science (New York, N.Y.). 323: 651-4. PMID 19179536 DOI: 10.1126/Science.1166562  0.684
2009 Lazarevic V, Zullo AJ, Schweitzer MN, Staton TL, Gallo EM, Crabtree GR, Glimcher LH. The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T cells. Nature Immunology. 10: 306-13. PMID 19169262 DOI: 10.1038/Ni.1696  0.677
2009 Wu JI, Lessard J, Crabtree GR. Understanding the words of chromatin regulation. Cell. 136: 200-6. PMID 19167321 DOI: 10.1016/J.Cell.2009.01.009  0.411
2008 Li DH, Winslow MM, Cao TM, Chen AH, Davis CR, Mellins ED, Utz PJ, Crabtree GR, Parnes JR. Modulation of peripheral B cell tolerance by CD72 in a murine model. Arthritis and Rheumatism. 58: 3192-204. PMID 18821699 DOI: 10.1002/Art.23812  0.682
2008 Gallo EM, Ho L, Winslow MM, Staton TL, Crabtree GR. Selective role of calcineurin in haematopoiesis and lymphopoiesis. Embo Reports. 9: 1141-8. PMID 18818667 DOI: 10.1038/Embor.2008.174  0.756
2008 Radermacher AN, Crabtree GR. Monster protein controls calcium entry and fights infection. Immunity. 28: 13-4. PMID 18199413 DOI: 10.1016/J.Immuni.2007.12.009  0.762
2007 Gallo EM, Winslow MM, Canté-Barrett K, Radermacher AN, Ho L, McGinnis L, Iritani B, Neilson JR, Crabtree GR. Calcineurin sets the bandwidth for discrimination of signals during thymocyte development. Nature. 450: 731-5. PMID 18046413 DOI: 10.1038/Nature06305  0.772
2007 Wu JI, Lessard J, Olave IA, Qiu Z, Ghosh A, Graef IA, Crabtree GR. Regulation of dendritic development by neuron-specific chromatin remodeling complexes. Neuron. 56: 94-108. PMID 17920018 DOI: 10.1016/J.Neuron.2007.08.021  0.474
2007 Wu H, Kao SC, Barrientos T, Baldwin SH, Olson EN, Crabtree GR, Zhou B, Chang CP. Down syndrome critical region-1 is a transcriptional target of nuclear factor of activated T cells-c1 within the endocardium during heart development. The Journal of Biological Chemistry. 282: 30673-9. PMID 17693409 DOI: 10.1074/Jbc.M703622200  0.684
2007 Lessard J, Wu JI, Ranish JA, Wan M, Winslow MM, Staahl BT, Wu H, Aebersold R, Graef IA, Crabtree GR. An essential switch in subunit composition of a chromatin remodeling complex during neural development. Neuron. 55: 201-15. PMID 17640523 DOI: 10.1016/J.Neuron.2007.06.019  0.803
2007 Stankunas K, Crabtree GR. Exploiting protein destruction for constructive use. Proceedings of the National Academy of Sciences of the United States of America. 104: 11511-2. PMID 17606901 DOI: 10.1073/Pnas.0704762104  0.707
2007 Wu JI, Crabtree GR, Crabtee GR. Cell signaling. Nuclear actin as choreographer of cell morphology and transcription. Science (New York, N.Y.). 316: 1710-1. PMID 17588921 DOI: 10.1126/science.1145014  0.41
2007 Canté-Barrett K, Winslow MM, Crabtree GR. Selective role of NFATc3 in positive selection of thymocytes. Journal of Immunology (Baltimore, Md. : 1950). 179: 103-10. PMID 17579027 DOI: 10.4049/Jimmunol.179.1.103  0.623
2007 Stankunas K, Bayle JH, Havranek JJ, Wandless TJ, Baker D, Crabtree GR, Gestwicki JE. Rescue of degradation-prone mutants of the FK506-rapamycin binding (FRB) protein with chemical ligands. Chembiochem : a European Journal of Chemical Biology. 8: 1162-9. PMID 17525916 DOI: 10.1002/Cbic.200700087  0.686
2007 Sellmyer MA, Stankunas K, Briesewitz R, Crabtree GR, Wandless TJ. Engineering small molecule specificity in nearly identical cellular environments. Bioorganic & Medicinal Chemistry Letters. 17: 2703-5. PMID 17383876 DOI: 10.1016/J.Bmcl.2007.03.012  0.674
2007 Pan M, Winslow MM, Chen L, Kuo A, Felsher D, Crabtree GR. Enhanced NFATc1 nuclear occupancy causes T cell activation independent of CD28 costimulation. Journal of Immunology (Baltimore, Md. : 1950). 178: 4315-21. PMID 17371988 DOI: 10.4049/Jimmunol.178.7.4315  0.603
2007 Liu KJ, Arron JR, Stankunas K, Crabtree GR, Longaker MT. Chemical rescue of cleft palate and midline defects in conditional GSK-3beta mice. Nature. 446: 79-82. PMID 17293880 DOI: 10.1038/Nature05557  0.651
2007 Pan M, Winslow MM, Keum JS, Crabtree GR. Stringent control of NFATc1 nuclear occupancy is critical for maintaining balanced immune response Gene Therapy and Molecular Biology. 11: 171-176.  0.54
2006 Davé V, Childs T, Xu Y, Ikegami M, Besnard V, Maeda Y, Wert SE, Neilson JR, Crabtree GR, Whitsett JA. Calcineurin/Nfat signaling is required for perinatal lung maturation and function. The Journal of Clinical Investigation. 116: 2597-609. PMID 16998587 DOI: 10.1172/Jci27331  0.57
2006 Heit JJ, Apelqvist AA, Gu X, Winslow MM, Neilson JR, Crabtree GR, Kim SK. Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function. Nature. 443: 345-9. PMID 16988714 DOI: 10.1038/Nature05097  0.72
2006 Ho L, Crabtree G. A Foxy tango with NFAT. Nature Immunology. 7: 906-8. PMID 16924253 DOI: 10.1038/ni0906-906  0.338
2006 Winslow MM, Pan M, Starbuck M, Gallo EM, Deng L, Karsenty G, Crabtree GR. Calcineurin/NFAT signaling in osteoblasts regulates bone mass. Developmental Cell. 10: 771-82. PMID 16740479 DOI: 10.1016/J.Devcel.2006.04.006  0.715
2006 Arron JR, Winslow MM, Polleri A, Chang CP, Wu H, Gao X, Neilson JR, Chen L, Heit JJ, Kim SK, Yamasaki N, Miyakawa T, Francke U, Graef IA, Crabtree GR. NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature. 441: 595-600. PMID 16554754 DOI: 10.1038/Nature04678  0.79
2006 Winslow MM, Gallo EM, Neilson JR, Crabtree GR. The calcineurin phosphatase complex modulates immunogenic B cell responses. Immunity. 24: 141-52. PMID 16473827 DOI: 10.1016/J.Immuni.2005.12.013  0.784
2006 Canté-Barrett K, Gallo EM, Winslow MM, Crabtree GR. Thymocyte negative selection is mediated by protein kinase C- and Ca2+-dependent transcriptional induction of bim [corrected]. Journal of Immunology (Baltimore, Md. : 1950). 176: 2299-306. PMID 16455986 DOI: 10.4049/Jimmunol.176.4.2299  0.752
2006 Bayle JH, Grimley JS, Stankunas K, Gestwicki JE, Wandless TJ, Crabtree GR. Rapamycin analogs with differential binding specificity permit orthogonal control of protein activity. Chemistry & Biology. 13: 99-107. PMID 16426976 DOI: 10.1016/J.Chembiol.2005.10.017  0.685
2006 Gallo EM, Canté-Barrett K, Crabtree GR. Lymphocyte calcium signaling from membrane to nucleus. Nature Immunology. 7: 25-32. PMID 16357855 DOI: 10.1038/Ni1295  0.63
2006 Canté-Barrett K, Gallo EM, Winslow MM, Crabtree GR. Thymocyte negative selection is mediated by protein kinase C- and Ca2+-dependent transcriptional induction of Bim of cell death. The Journal of Immunology. 176: 3843.3-3843. DOI: 10.4049/jimmunol.176.6.3843-b  0.633
2006 Liu KJ, Arron JR, Stankunas K, Crabtree GR. Signaling via GSK-3 is required during midline skeletogenesis Developmental Biology. 295: 434-435. DOI: 10.1016/J.Ydbio.2006.04.337  0.657
2006 Polleri A, Graef IA, Arron JR, Winslow MM, Kim SK, Miyakawa T, Francke U, Crabtree GR. Increased dosage of DSCR1 and DYRK1A on chromosome 21 destabilizes NFAT regulation and accounts for Down syndrome phenotypes Developmental Biology. 295: 324. DOI: 10.1016/J.Ydbio.2006.04.007  0.553
2005 Mammucari C, Tommasi di Vignano A, Sharov AA, Neilson J, Havrda MC, Roop DR, Botchkarev VA, Crabtree GR, Dotto GP. Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control. Developmental Cell. 8: 665-76. PMID 15866158 DOI: 10.1016/J.Devcel.2005.02.016  0.617
2005 Winslow MM, Crabtree GR. Immunology. Decoding calcium signaling. Science (New York, N.Y.). 307: 56-7. PMID 15637261 DOI: 10.1126/Science.1108163  0.569
2004 Liston A, Lesage S, Gray DH, O'Reilly LA, Strasser A, Fahrer AM, Boyd RL, Wilson J, Baxter AG, Gallo EM, Crabtree GR, Peng K, Wilson SR, Goodnow CC. Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim. Immunity. 21: 817-30. PMID 15589170 DOI: 10.1016/J.Immuni.2004.10.014  0.647
2004 Chang CP, Neilson JR, Bayle JH, Gestwicki JE, Kuo A, Stankunas K, Graef IA, Crabtree GR. A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis. Cell. 118: 649-63. PMID 15339668 DOI: 10.1016/J.Cell.2004.08.010  0.774
2004 Parsons SA, Millay DP, Wilkins BJ, Bueno OF, Tsika GL, Neilson JR, Liberatore CM, Yutzey KE, Crabtree GR, Tsika RW, Molkentin JD. Genetic loss of calcineurin blocks mechanical overload-induced skeletal muscle fiber type switching but not hypertrophy. The Journal of Biological Chemistry. 279: 26192-200. PMID 15082723 DOI: 10.1074/Jbc.M313800200  0.573
2004 Aramburu J, Heitman J, Crabtree GR. Calcineurin: a central controller of signalling in eukaryotes. Embo Reports. 5: 343-8. PMID 15060569 DOI: 10.1038/Sj.Embor.7400133  0.323
2004 Chang CP, McDill BW, Neilson JR, Joist HE, Epstein JA, Crabtree GR, Chen F. Calcineurin is required in urinary tract mesenchyme for the development of the pyeloureteral peristaltic machinery. The Journal of Clinical Investigation. 113: 1051-8. PMID 15057312 DOI: 10.1172/Jci20049  0.729
2004 Neilson JR, Winslow MM, Hur EM, Crabtree GR. Calcineurin B1 is essential for positive but not negative selection during thymocyte development. Immunity. 20: 255-66. PMID 15030770 DOI: 10.1016/S1074-7613(04)00052-4  0.726
2003 Stankunas K, Bayle JH, Gestwicki JE, Lin YM, Wandless TJ, Crabtree GR. Conditional protein alleles using knockin mice and a chemical inducer of dimerization. Molecular Cell. 12: 1615-24. PMID 14690613 DOI: 10.1016/S1097-2765(03)00491-X  0.693
2003 Chi TH, Wan M, Lee PP, Akashi K, Metzger D, Chambon P, Wilson CB, Crabtree GR. Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte development. Immunity. 19: 169-82. PMID 12932351 DOI: 10.1016/S1074-7613(03)00199-7  0.323
2003 Winslow MM, Neilson JR, Crabtree GR. Calcium signalling in lymphocytes. Current Opinion in Immunology. 15: 299-307. PMID 12787755 DOI: 10.1016/S0952-7915(03)00050-5  0.695
2003 Graef IA, Wang F, Charron F, Chen L, Neilson J, Tessier-Lavigne M, Crabtree GR. Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. Cell. 113: 657-70. PMID 12787506 DOI: 10.1016/S0092-8674(03)00390-8  0.564
2003 Chang CP, Chen L, Crabtree GR. Sonographic staging of the developmental status of mouse embryos in utero. Genesis (New York, N.Y. : 2000). 36: 7-11. PMID 12748962 DOI: 10.1002/Gene.10186  0.602
2003 Rando OJ, Chi TH, Crabtree GR. Second messenger control of chromatin remodeling. Nature Structural Biology. 10: 81-3. PMID 12555081 DOI: 10.1038/Nsb0203-81  0.6
2002 Olave I, Wang W, Xue Y, Kuo A, Crabtree GR. Identification of a polymorphic, neuron-specific chromatin remodeling complex. Genes & Development. 16: 2509-17. PMID 12368262 DOI: 10.1101/Gad.992102  0.473
2002 Diehn M, Alizadeh AA, Rando OJ, Liu CL, Stankunas K, Botstein D, Crabtree GR, Brown PO. Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation. Proceedings of the National Academy of Sciences of the United States of America. 99: 11796-801. PMID 12195013 DOI: 10.1073/Pnas.092284399  0.765
2002 Chi TH, Wan M, Zhao K, Taniuchi I, Chen L, Littman DR, Crabtree GR. Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes. Nature. 418: 195-9. PMID 12110891 DOI: 10.1038/Nature00876  0.525
2002 Crabtree GR, Olson EN. NFAT signaling: choreographing the social lives of cells. Cell. 109: S67-79. PMID 11983154 DOI: 10.1016/S0092-8674(02)00699-2  0.307
2002 Rando OJ, Zhao K, Janmey P, Crabtree GR. Phosphatidylinositol-dependent actin filament binding by the SWI/SNF-like BAF chromatin remodeling complex. Proceedings of the National Academy of Sciences of the United States of America. 99: 2824-9. PMID 11880634 DOI: 10.1073/Pnas.032662899  0.676
2001 Biggar SR, Crabtree GR. Cell signaling can direct either binary or graded transcriptional responses. The Embo Journal. 20: 3167-76. PMID 11406593 DOI: 10.1093/Emboj/20.12.3167  0.811
2001 Neilson J, Stankunas K, Crabtree GR. Monitoring the duration of antigen-receptor occupancy by calcineurin/glycogen-synthase-kinase-3 control of NF-AT nuclear shuttling. Current Opinion in Immunology. 13: 346-50. PMID 11406367 DOI: 10.1016/S0952-7915(00)00225-9  0.751
2000 Bultman S, Gebuhr T, Yee D, La Mantia C, Nicholson J, Gilliam A, Randazzo F, Metzger D, Chambon P, Crabtree G, Magnuson T. A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes. Molecular Cell. 6: 1287-95. PMID 11163203 DOI: 10.1016/S1097-2765(00)00127-1  0.428
2000 Biggar SR, Crabtree GR. Chemically regulated transcription factors reveal the persistence of repressor-resistant transcription after disrupting activator function. The Journal of Biological Chemistry. 275: 25381-90. PMID 10801867 DOI: 10.1074/Jbc.M002991200  0.813
2000 Rando OJ, Zhao K, Crabtree GR. Searching for a function for nuclear actin. Trends in Cell Biology. 10: 92-7. PMID 10675902 DOI: 10.1016/S0962-8924(99)01713-4  0.657
1999 Stankunas K, Graef IA, Neilson JR, Park SH, Crabtree GR. Signaling through calcium, calcineurin, and NF-AT in lymphocyte activation and development. Cold Spring Harbor Symposia On Quantitative Biology. 64: 505-16. PMID 11232327 DOI: 10.1101/Sqb.1999.64.505  0.748
1999 Graef IA, Mermelstein PG, Stankunas K, Neilson JR, Deisseroth K, Tsien RW, Crabtree GR. L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons. Nature. 401: 703-8. PMID 10537109 DOI: 10.1038/44378  0.771
1999 Biggar SR, Crabtree GR. Continuous and widespread roles for the Swi-Snf complex in transcription. The Embo Journal. 18: 2254-64. PMID 10205178 DOI: 10.1093/Emboj/18.8.2254  0.82
1998 Zhao K, Wang W, Rando OJ, Xue Y, Swiderek K, Kuo A, Crabtree GR. Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling. Cell. 95: 625-36. PMID 9845365 DOI: 10.1016/S0092-8674(00)81633-5  0.753
1998 Ring HZ, Vameghi-Meyers V, Wang W, Crabtree GR, Francke U. Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome. Genomics. 51: 140-3. PMID 9693044 DOI: 10.1006/Geno.1998.5343  0.382
1998 Wang W, Chi T, Xue Y, Zhou S, Kuo A, Crabtree GR. Architectural DNA binding by a high-mobility-group/kinesin-like subunit in mammalian SWI/SNF-related complexes. Proceedings of the National Academy of Sciences of the United States of America. 95: 492-8. PMID 9435219 DOI: 10.1073/Pnas.95.2.492  0.479
1997 Borchardt A, Liberles SD, Biggar SR, Crabtree GR, Schreiber SL. Small molecule-dependent genetic selection in stochastic nanodroplets as a means of detecting protein-ligand interactions on a large scale. Chemistry & Biology. 4: 961-8. PMID 9427663 DOI: 10.1016/S1074-5521(97)90304-5  0.783
1997 Freiberg RA, Spencer DM, Choate KA, Duh HJ, Schreiber SL, Crabtree GR, Khavari PA. Fas signal transduction triggers either proliferation or apoptosis in human fibroblasts. The Journal of Investigative Dermatology. 108: 215-9. PMID 9008237 DOI: 10.1111/1523-1747.Ep12334273  0.505
1996 Freiberg RA, Spencer DM, Choate KA, Peng PD, Schreiber SL, Crabtree GR, Khavari PA. Specific triggering of the Fas signal transduction pathway in normal human keratinocytes. The Journal of Biological Chemistry. 271: 31666-9. PMID 8940187 DOI: 10.1074/Jbc.271.49.31666  0.546
1996 Wang W, Côté J, Xue Y, Zhou S, Khavari PA, Biggar SR, Muchardt C, Kalpana GV, Goff SP, Yaniv M, Workman JL, Crabtree GR. Purification and biochemical heterogeneity of the mammalian SWI-SNF complex. The Embo Journal. 15: 5370-82. PMID 8895581  0.809
1996 Wang W, Xue Y, Zhou S, Kuo A, Cairns BR, Crabtree GR. Diversity and specialization of mammalian SWI/SNF complexes. Genes & Development. 10: 2117-30. PMID 8804307 DOI: 10.1101/Gad.10.17.2117  0.5
1996 Ho SN, Biggar SR, Spencer DM, Schreiber SL, Crabtree GR. Dimeric ligands define a role for transcriptional activation domains in reinitiation. Nature. 382: 822-6. PMID 8752278 DOI: 10.1038/382822A0  0.812
1996 Wang W, Côté J, Xue Y, Zhou S, Khavari PA, Biggar SR, Muchardt C, Kalpana GV, Goff SP, Yaniv M, Workman JL, Crabtree GR. Purification and biochemical heterogeneity of the mammalian SWI-SNF complex. The Embo Journal. 15: 5370-5382. DOI: 10.1002/J.1460-2075.1996.Tb00921.X  0.804
1995 Endrizzi JA, Cronk JD, Wang W, Crabtree GR, Alber T. Crystal structure of DCoH, a bifunctional, protein-binding transcriptional coactivator. Science (New York, N.Y.). 268: 556-9. PMID 7725101 DOI: 10.1126/Science.7725101  0.381
1994 Dunaief JL, Strober BE, Guha S, Khavari PA, Alin K, Luban J, Begemann M, Crabtree GR, Goff SP. The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest. Cell. 79: 119-30. PMID 7923370 DOI: 10.1016/0092-8674(94)90405-7  0.588
1994 Randazzo FM, Khavari P, Crabtree G, Tamkun J, Rossant J. brg1: a putative murine homologue of the Drosophila brahma gene, a homeotic gene regulator. Developmental Biology. 161: 229-42. PMID 7904967 DOI: 10.1006/Dbio.1994.1023  0.586
1994 Kalpana GV, Marmon S, Wang W, Crabtree GR, Goff SP. Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5. Science (New York, N.Y.). 266: 2002-6. PMID 7801128 DOI: 10.1126/Science.7801128  0.435
1993 Khavari PA, Peterson CL, Tamkun JW, Mendel DB, Crabtree GR. BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription. Nature. 366: 170-4. PMID 8232556 DOI: 10.1038/366170A0  0.583
1992 Kuo CJ, Conley PB, Chen L, Sladek FM, Darnell JE, Crabtree GR. A transcriptional hierarchy involved in mammalian cell-type specification. Nature. 355: 457-61. PMID 1734282 DOI: 10.1038/355457A0  0.527
1992 Kuo CJ, Chung J, Fiorentino DF, Flanagan WM, Blenis J, Crabtree GR. Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Nature. 358: 70-3. PMID 1614535 DOI: 10.1038/358070A0  0.566
1992 Chung J, Kuo CJ, Crabtree GR, Blenis J. Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases. Cell. 69: 1227-36. PMID 1377606 DOI: 10.1016/0092-8674(92)90643-Q  0.524
1991 Mendel DB, Khavari PA, Conley PB, Graves MK, Hansen LP, Admon A, Crabtree GR. Characterization of a cofactor that regulates dimerization of a mammalian homeodomain protein. Science (New York, N.Y.). 254: 1762-7. PMID 1763325 DOI: 10.1126/Science.1763325  0.541
1990 Kuo CJ, Conley PB, Hsieh CL, Francke U, Crabtree GR. Molecular cloning, functional expression, and chromosomal localization of mouse hepatocyte nuclear factor 1. Proceedings of the National Academy of Sciences of the United States of America. 87: 9838-42. PMID 2263635 DOI: 10.1073/Pnas.87.24.9838  0.545
1990 Baumhueter S, Mendel DB, Conley PB, Kuo CJ, Turk C, Graves MK, Edwards CA, Courtois G, Crabtree GR. HNF-1 shares three sequence motifs with the POU domain proteins and is identical to LF-B1 and APF. Genes & Development. 4: 372-9. PMID 1970973 DOI: 10.1101/gad.4.3.372  0.542
1981 Crabtree GR, Bloomfield CD, Smith KA, McKenna RW, Peterson BA, Hildebrandt L, Munck A. Glucocorticoid receptors and in vitro responses to glucocorticoid in acute nonlymphocytic leukemia. Cancer Research. 41: 4853-6. PMID 7296546  0.431
1981 Guyre PM, Crabtree GR, Bodwell JE, Munck A. MLC-conditioned media stimulate an increase in Fc receptors on human macrophages. Journal of Immunology (Baltimore, Md. : 1950). 126: 666-8. PMID 6450248  0.444
1980 Crabtree GR, Munck A, Smith KA. Glucocorticoids and lymphocytes. II. Cell cycle-dependent changes in glucocorticoid receptor content. Journal of Immunology (Baltimore, Md. : 1950). 125: 13-7. PMID 7381199  0.438
1980 Crabtree GR, Munck A, Smith KA. Glucocorticoids and lymphocytes. I. Increased glucocorticoid receptor levels in antigen-stimulated lymphocytes. Journal of Immunology (Baltimore, Md. : 1950). 124: 2430-5. PMID 7365260  0.455
1980 Crabtree GR, Gillis S, Smith KA, Munck A. Mechanisms of glucocorticoid-induced immunosuppression: inhibitory effects on expression of Fc receptors and production of T-cell growth factor. Journal of Steroid Biochemistry. 12: 445-9. PMID 6968381 DOI: 10.1016/0022-4731(80)90305-2  0.471
1979 Munck A, Crabtree GR, Smith KA. Glucocorticoid receptors and actions in rat thymocytes and immunologically stimulated human peripheral lymphocytes. Monographs On Endocrinology. 12: 341-55. PMID 492174 DOI: 10.1007/978-3-642-81265-1_19  0.453
1979 Crabtree GR, Munck A, Smith KA. Glucocorticoids inhibit expression of Fc receptors on the human granulocytic cell line HL-60. Nature. 279: 338-9. PMID 450087 DOI: 10.1038/279338A0  0.474
1979 Crabtree GR, Gillis S, Smith KA, Munck A. Glucocorticoids and immune responses. Arthritis and Rheumatism. 22: 1246-56. PMID 389249 DOI: 10.1002/art.1780221112  0.487
1978 Munck A, Crabtree GR, Smith KA. Effects and receptors of glucocorticoids in rat thymus cells and human peripheral lymphocytes. Journal of Toxicology and Environmental Health. 4: 409-25. PMID 351204 DOI: 10.1080/15287397809529668  0.483
1978 Crabtree GR, Smith KA, Munck A. Glucocorticoid receptors and sensitivity of isolated human leukemia and lymphoma cells. Cancer Research. 38: 4268-72. PMID 279402  0.427
1977 Smith KA, Crabtree GR, Kennedy SJ, Munck AU. Glucocorticoid receptors and glucocorticoid sensitivity of mitogen stimulated and unstimulated human lymphocytes. Nature. 267: 523-6. PMID 876370 DOI: 10.1038/267523a0  0.406
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