Eric E. Schadt, Ph.D. - Publications

Affiliations: 
University of California, Los Angeles, Los Angeles, CA 

250 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Guin S, Liaw BK, Jun T, Ayers K, Patel B, O'Connell T, Deitz M, Klein M, Mullaney T, Prentice T, Newman S, Fink M, Zhou X, Schadt EE, Chen R, et al. Management of de novo metastatic hormone-sensitive prostate cancer: A comprehensive report of a single-center experience. Plos One. 17: e0264800. PMID 35984843 DOI: 10.1371/journal.pone.0264800  0.611
2022 Mack PC, Klein MI, Ayers KL, Zhou X, Guin S, Fink M, Rossi M, Ai-Kateb H, O'Connell T, Hantash FM, Oh WK, Newman S, Schadt EE, Chen R, Hirsch FR. Targeted Next-Generation Sequencing Reveals Exceptionally High Rates of Molecular Driver Mutations in Never-Smokers With Lung Adenocarcinoma. The Oncologist. PMID 35298662 DOI: 10.1093/oncolo/oyac035  0.622
2022 Patel R, Li Z, Zimmerman BS, Fink MY, Wells JD, Zhou X, Ayers K, Redfern A, Newman S, Schadt E, Oh WK, Chen R, Tiersten A. Impact of body mass index on the efficacy of aromatase inhibitors in patients with metastatic breast cancer. Breast Cancer Research and Treatment. PMID 35006484 DOI: 10.1007/s10549-021-06504-0  0.621
2021 Ayers KL, Ma M, Debussche G, Corrigan D, McCafferty J, Lee K, Newman S, Zhou X, Hirsch FR, Mack PC, Liu JJ, Schadt EE, Chen R, Li SD. A composite biomarker of neutrophil-lymphocyte ratio and hemoglobin level correlates with clinical response to PD-1 and PD-L1 inhibitors in advanced non-small cell lung cancers. Bmc Cancer. 21: 441. PMID 33882890 DOI: 10.1186/s12885-021-08194-9  0.625
2021 Ayers KL, Mullaney T, Zhou X, Liu JJ, Lee K, Ma M, Jones S, Li L, Redfern A, Jappe W, Liu Z, Goldsweig H, Yadav KK, Hahner N, Dietz M, ... ... Schadt EE, et al. Analysis of real-world data to investigate the impact of race and ethnicity on response to PD-1 and PD-L1 inhibitors in advanced non-small cell lung cancers. The Oncologist. PMID 33829580 DOI: 10.1002/onco.13780  0.622
2020 Wang Z, Zheutlin A, Kao YH, Ayers K, Gross S, Kovatch P, Nirenberg S, Charney A, Nadkarni G, De Freitas JK, O'Reilly P, Just A, Horowitz C, Martin G, Branch A, ... ... Schadt E, et al. Hospitalised COVID-19 patients of the Mount Sinai Health System: a retrospective observational study using the electronic medical records. Bmj Open. 10: e040441. PMID 33109676 DOI: 10.1136/bmjopen-2020-040441  0.615
2020 Scott SA, Scott ER, Seki Y, Chen AJ, Wallsten R, Owusu Obeng A, Botton MR, Cody N, Shi H, Zhao G, Brake P, Nicoletti P, Yang Y, Delio M, Shi L, ... ... Schadt EE, et al. Development and Analytical Validation of a 29 Gene Clinical Pharmacogenetic Genotyping Panel: Multi-Ethnic Allele and Copy Number Variant Detection. Clinical and Translational Science. PMID 32931151 DOI: 10.1111/Cts.12844  0.351
2020 Beckmann ND, Lin WJ, Wang M, Cohain AT, Charney AW, Wang P, Ma W, Wang YC, Jiang C, Audrain M, Comella PH, Fakira AK, Hariharan SP, Belbin GM, Girdhar K, ... ... Schadt EE, et al. Multiscale causal networks identify VGF as a key regulator of Alzheimer's disease. Nature Communications. 11: 3942. PMID 32770063 DOI: 10.1038/S41467-020-17405-Z  0.307
2020 Wan YW, Al-Ouran R, Mangleburg CG, Perumal TM, Lee TV, Allison K, Swarup V, Funk CC, Gaiteri C, Allen M, Wang M, Neuner SM, Kaczorowski CC, Philip VM, Howell GR, ... ... Schadt E, et al. Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models. Cell Reports. 32: 107908. PMID 32668255 DOI: 10.1016/J.Celrep.2020.107908  0.314
2020 Richter F, Morton SU, Kim SW, Kitaygorodsky A, Wasson LK, Chen KM, Zhou J, Qi H, Patel N, DePalma SR, Parfenov M, Homsy J, Gorham JM, Manheimer KB, Velinder M, ... ... Schadt EE, et al. Genomic analyses implicate noncoding de novo variants in congenital heart disease. Nature Genetics. PMID 32601476 DOI: 10.1038/S41588-020-0652-Z  0.348
2020 Gopinath S, Cagan R, Schadt E. Abstract B17: Modeling genomic complexity of colorectal cancer using multigenic Drosophila models Cancer Research. 80. DOI: 10.1158/1538-7445.Camodels2020-B17  0.307
2019 Etheridge AS, Gallins PJ, Jima D, Broadaway KA, Ratain MJ, Schuetz E, Schadt E, Schroder A, Molony C, Zhou Y, Mohlke KL, Wright FA, Innocenti F. A new liver eQTL map from 1,183 individuals provides evidence for novel eQTLs of drug response, metabolic and sex-biased phenotypes. Clinical Pharmacology and Therapeutics. PMID 31868224 DOI: 10.1002/Cpt.1751  0.365
2019 Oliveira PH, Ribis JW, Garrett EM, Trzilova D, Kim A, Sekulovic O, Mead EA, Pak T, Zhu S, Deikus G, Touchon M, Lewis-Sandari M, Beckford C, Zeitouni NE, Altman DR, ... ... Schadt EE, et al. Epigenomic characterization of Clostridioides difficile finds a conserved DNA methyltransferase that mediates sporulation and pathogenesis. Nature Microbiology. PMID 31768029 DOI: 10.1038/S41564-019-0613-4  0.356
2019 Glicksberg BS, Amadori L, Akers NK, Sukhavasi K, Franzén O, Li L, Belbin GM, Ayers KL, Shameer K, Badgeley MA, Johnson KW, Readhead B, Darrow BJ, Kenny EE, Betsholtz C, ... ... Schadt EE, et al. Correction to: Integrative analysis of loss-of-function variants in clinical and genomic data reveals novel genes associated with cardiovascular traits. Bmc Medical Genomics. 12: 154. PMID 31684948 DOI: 10.1186/s12920-019-0573-9  0.692
2019 Clark DJ, Dhanasekaran SM, Petralia F, Pan J, Song X, Hu Y, da Veiga Leprevost F, Reva B, Lih TM, Chang HY, Ma W, Huang C, Ricketts CJ, Chen L, Krek A, ... ... Schadt E, et al. Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma. Cell. 179: 964-983.e31. PMID 31675502 DOI: 10.1016/J.Cell.2019.10.007  0.322
2019 Sullivan MJ, Altman DR, Chacko KI, Ciferri B, Webster E, Pak TR, Deikus G, Lewis-Sandari M, Khan Z, Beckford C, Rendo A, Samaroo F, Sebra R, Karam-Howlin R, Dingle T, ... ... Schadt E, et al. A complete genome screening program of clinical methicillin-resistant isolates identifies the origin and progression of a neonatal intensive care unit outbreak. Journal of Clinical Microbiology. PMID 31578260 DOI: 10.1128/Jcm.01261-19  0.333
2019 Hoffman GE, Bendl J, Girdhar K, Schadt EE, Roussos P. Functional interpretation of genetic variants using deep learning predicts impact on chromatin accessibility and histone modification. Nucleic Acids Research. PMID 31544924 DOI: 10.1093/Nar/Gkz808  0.331
2019 Fang G, Wang W, Paunic V, Heydari H, Costanzo M, Liu X, Liu X, VanderSluis B, Oately B, Steinbach M, Van Ness B, Schadt EE, Pankratz ND, Boone C, Kumar V, et al. Discovering genetic interactions bridging pathways in genome-wide association studies. Nature Communications. 10: 4274. PMID 31537791 DOI: 10.1038/S41467-019-12131-7  0.395
2019 Zhang W, Voloudakis G, Rajagopal VM, Readhead B, Dudley JT, Schadt EE, Björkegren JLM, Kim Y, Fullard JF, Hoffman GE, Roussos P. Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traits. Nature Communications. 10: 3834. PMID 31444360 DOI: 10.1038/S41467-019-11874-7  0.426
2019 Glicksberg BS, Amadori L, Akers NK, Sukhavasi K, Franzén O, Li L, Belbin GM, Akers KL, Shameer K, Badgeley MA, Johnson KW, Readhead B, Darrow BJ, Kenny EE, Betsholtz C, ... ... Schadt EE, et al. Integrative analysis of loss-of-function variants in clinical and genomic data reveals novel genes associated with cardiovascular traits. Bmc Medical Genomics. 12: 108. PMID 31345219 DOI: 10.1186/S12920-019-0542-3  0.416
2019 Zeng L, Talukdar HA, Koplev S, Giannarelli C, Ivert T, Gan LM, Ruusalepp A, Schadt EE, Kovacic JC, Lusis AJ, Michoel T, Schunkert H, Björkegren JLM. Contribution of Gene Regulatory Networks to Heritability of Coronary Artery Disease. Journal of the American College of Cardiology. 73: 2946-2957. PMID 31196451 DOI: 10.1016/J.Jacc.2019.03.520  0.327
2019 Zhu J, Liu Y, Wang L, Yu H, Yoo S, Lee E, Schadt EE. Inching towards precision medicine for multiple myeloma with causal network models. Journal of Clinical Oncology. 37: e19526-e19526. DOI: 10.1200/Jco.2019.37.15_Suppl.E19526  0.339
2019 Kueffner R, Li H, Cheung K, Fink M, Soens Z, Wang J, Siddiqui O, Thiumurthi U, Uzilov A, Song C, Villar J, Pollock A, Jeganathan B, Zimmermann M, Kip NS, ... ... Schadt E, et al. VONC: A solution for the clinical assessment of somatic genomic alterations. Journal of Clinical Oncology. 37: e13155-e13155. DOI: 10.1200/Jco.2019.37.15_Suppl.E13155  0.337
2019 Zhang W, Voloudakis G, Rajagopal V, Schadt E, Björkegren J, Fullard J, Hoffman G, Roussos P. 237. Large-Scale Gene-Trait Association Study Identifies Novel Genes Across Multiple Traits Biological Psychiatry. 85. DOI: 10.1016/J.Biopsych.2019.03.251  0.364
2018 Franceschini N, Giambartolomei C, de Vries PS, Finan C, Bis JC, Huntley RP, Lovering RC, Tajuddin SM, Winkler TW, Graff M, Kavousi M, Dale C, Smith AV, Hofer E, van Leeuwen EM, ... ... Schadt EE, et al. GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes. Nature Communications. 9: 5141. PMID 30510157 DOI: 10.1038/S41467-018-07340-5  0.345
2018 Nanda V, Wang T, Pjanic M, Liu B, Nguyen T, Matic LP, Hedin U, Koplev S, Ma L, Franzén O, Ruusalepp A, Schadt EE, Björkegren JLM, Montgomery SB, Snyder MP, et al. Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus. Plos Genetics. 14: e1007755. PMID 30444878 DOI: 10.1371/Journal.Pgen.1007755  0.338
2018 Audrain M, Haure-Mirande JV, Wang M, Kim SH, Fanutza T, Chakrabarty P, Fraser P, St George-Hyslop PH, Golde TE, Blitzer RD, Schadt EE, Zhang B, Ehrlich ME, Gandy S. Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau. Molecular Psychiatry. PMID 30283031 DOI: 10.1038/S41380-018-0258-3  0.319
2018 Wang M, Beckmann ND, Roussos P, Wang E, Zhou X, Wang Q, Ming C, Neff R, Ma W, Fullard JF, Hauberg ME, Bendl J, Peters MA, Logsdon B, Wang P, ... ... Schadt E, et al. The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease. Scientific Data. 5: 180185. PMID 30204156 DOI: 10.1038/Sdata.2018.185  0.328
2018 Petyuk VA, Chang R, Ramirez-Restrepo M, Beckmann ND, Henrion MYR, Piehowski PD, Zhu K, Wang S, Clarke J, Huentelman MJ, Xie F, Andreev V, Engel A, Guettoche T, Navarro L, ... ... Schadt E, et al. The human brainome: network analysis identifies HSPA2 as a novel Alzheimer's disease target. Brain : a Journal of Neurology. PMID 30137212 DOI: 10.1093/Brain/Awy215  0.334
2018 Readhead B, Haure-Mirande JV, Funk CC, Richards MA, Shannon P, Haroutunian V, Sano M, Liang WS, Beckmann ND, Price ND, Reiman EM, Schadt EE, Ehrlich ME, Gandy S, Dudley JT. Multiscale Analysis of Independent Alzheimer's Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus. Neuron. PMID 29937276 DOI: 10.1016/J.Neuron.2018.05.023  0.313
2018 Zhu S, Beaulaurier J, Deikus G, Wu T, Strahl M, Hao Z, Luo G, Gregory JA, Chess A, He C, Xiao A, Sebra R, Schadt EE, Fang G. Mapping and characterizing N6-methyladenine in eukaryotic genomes using single molecule real-time sequencing. Genome Research. PMID 29764913 DOI: 10.1101/Gr.231068.117  0.314
2018 Hauberg ME, Fullard JF, Zhu L, Cohain AT, Giambartolomei C, Misir R, Reach S, Johnson JS, Wang M, Mattheisen M, Børglum AD, Zhang B, Sieberts SK, Peters MA, Domenici E, ... Schadt EE, et al. Differential activity of transcribed enhancers in the prefrontal cortex of 537 cases with schizophrenia and controls. Molecular Psychiatry. PMID 29740122 DOI: 10.1038/S41380-018-0059-8  0.364
2018 Ayers KL, Glicksberg BS, Garfield AS, Longerich S, White JA, Yang P, Du L, Chittenden TW, Gulcher JR, Roy S, Fiedorek F, Gottesdiener K, Cohen S, North KE, Schadt EE, et al. Melanocortin-4 receptor pathway dysfunction in obesity: Patient stratification aimed at MC4R agonist treatment. The Journal of Clinical Endocrinology and Metabolism. PMID 29726959 DOI: 10.1210/Jc.2018-00258  0.661
2018 Franzén O, Ermel R, Sukhavasi K, Jain R, Jain A, Betsholtz C, Giannarelli C, Kovacic JC, Ruusalepp A, Skogsberg J, Hao K, Schadt EE, Björkegren JLM. Global analysis of A-to-I RNA editing reveals association with common disease variants. Peerj. 6: e4466. PMID 29527417 DOI: 10.7717/Peerj.4466  0.317
2018 Suarez-Farinas M, Huang R, Kosoy R, Irizar A, Losic B, Wei G, Peters L, Song W-, Di Narzo A, Wang W, Perrigoue J, Castillo A, Rogers J, Atreja A, Hurley A, ... ... Schadt E, et al. DOP012 Disease demarcation in ulcerative colitis is associated with different patterns of gene expression Journal of Crohn's and Colitis. 12: S038-S038. DOI: 10.1093/Ecco-Jcc/Jjx180.049  0.332
2018 Suarez-Farinas M, Huang R, Kosoy R, Irizar A, Losic B, Wei G, Peters LA, Song W, Di Narzo AF, Wang W, Perrigoue J, Castillo A, Rogers J, Atreja A, Hurley A, ... ... Schadt EE, et al. Tu1802 - Disease Demarcation in Ulcerative Colitis is Associated with Different Patterns of Gene Expression Gastroenterology. 154: S-1024. DOI: 10.1016/S0016-5085(18)33428-0  0.332
2017 Watson CT, Cohain AT, Griffin RS, Chun Y, Grishin A, Hacyznska H, Hoffman GE, Beckmann ND, Shah H, Dawson P, Henning A, Wood R, Burks AW, Jones SM, Leung DYM, ... ... Schadt EE, et al. Integrative transcriptomic analysis reveals key drivers of acute peanut allergic reactions. Nature Communications. 8: 1943. PMID 29203772 DOI: 10.1038/S41467-017-02188-7  0.314
2017 Zillikens MC, Demissie S, Hsu YH, Yerges-Armstrong LM, Chou WC, Stolk L, Livshits G, Broer L, Johnson T, Koller DL, Kutalik Z, Luan J, Malkin I, Ried JS, Smith AV, ... ... Schadt EE, et al. Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. Nature Communications. 8: 1414. PMID 29116125 DOI: 10.1038/s41467-017-01008-2  0.448
2017 Peters LA, Perrigoue J, Mortha A, Iuga A, Song WM, Neiman EM, Llewellyn SR, Di Narzo A, Kidd BA, Telesco SE, Zhao Y, Stojmirovic A, Sendecki J, Shameer K, Miotto R, ... ... Schadt EE, et al. A functional genomics predictive network model identifies regulators of inflammatory bowel disease. Nature Genetics. PMID 28892060 DOI: 10.1038/Ng.3947  0.368
2017 Zillikens MC, Demissie S, Hsu YH, Yerges-Armstrong LM, Chou WC, Stolk L, Livshits G, Broer L, Johnson T, Koller DL, Kutalik Z, Luan J, Malkin I, Ried JS, Smith AV, ... ... Schadt EE, et al. Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. Nature Communications. 8: 80. PMID 28724990 DOI: 10.1038/S41467-017-00031-7  0.497
2017 Nelson CP, Goel A, Butterworth AS, Kanoni S, Webb TR, Marouli E, Zeng L, Ntalla I, Lai FY, Hopewell JC, Giannakopoulou O, Jiang T, Hamby SE, Di Angelantonio E, Assimes TL, ... ... Schadt EE, et al. Association analyses based on false discovery rate implicate new loci for coronary artery disease. Nature Genetics. PMID 28714975 DOI: 10.1038/Ng.3913  0.366
2017 Haure-Mirande JV, Audrain M, Fanutza T, Kim SH, Klein WL, Glabe C, Readhead B, Dudley JT, Blitzer RD, Wang M, Zhang B, Schadt EE, Gandy S, Ehrlich ME. Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology. Acta Neuropathologica. PMID 28612290 DOI: 10.1007/S00401-017-1737-3  0.3
2017 Hauberg ME, Zhang W, Giambartolomei C, Franzén O, Morris DL, Vyse TJ, Ruusalepp A, Sklar P, Schadt EE, Björkegren JLM, Roussos P. Large-Scale Identification of Common Trait and Disease Variants Affecting Gene Expression. American Journal of Human Genetics. PMID 28552197 DOI: 10.1016/J.Ajhg.2017.04.016  0.423
2017 Webb TR, Erdmann J, Stirrups KE, Stitziel NO, Masca NG, Jansen H, Kanoni S, Nelson CP, Ferrario PG, König IR, Eicher JD, Johnson AD, Hamby SE, Betsholtz C, Ruusalepp A, ... ... Schadt EE, et al. Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease. Journal of the American College of Cardiology. 69: 823-836. PMID 28209224 DOI: 10.1016/J.Jacc.2016.11.056  0.307
2017 Di Narzo AF, Telesco SE, Brodmerkel C, Argmann C, Peters LA, Li K, Kidd B, Dudley J, Cho J, Schadt EE, Kasarskis A, Dobrin R, Hao K. High-Throughput Characterization of Blood Serum Proteomics of IBD Patients with Respect to Aging and Genetic Factors. Plos Genetics. 13: e1006565. PMID 28129359 DOI: 10.1371/Journal.Pgen.1006565  0.357
2017 Mendelson MM, Marioni RE, Joehanes R, Liu C, Hedman ÅK, Aslibekyan S, Demerath EW, Guan W, Zhi D, Yao C, Huan T, Willinger C, Chen B, Courchesne P, Multhaup M, ... ... Schadt EE, et al. Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach. Plos Medicine. 14: e1002215. PMID 28095459 DOI: 10.1371/Journal.Pmed.1002215  0.306
2016 Carcamo-Orive I, Hoffman GE, Cundiff P, Beckmann ND, D'Souza SL, Knowles JW, Patel A, Papatsenko D, Abbasi F, Reaven GM, Whalen S, Lee P, Shahbazi M, Henrion MY, Zhu K, ... ... Schadt EE, et al. Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity. Cell Stem Cell. PMID 28017796 DOI: 10.1016/J.Stem.2016.11.005  0.369
2016 Fromer M, Roussos P, Sieberts SK, Johnson JS, Kavanagh DH, Perumal TM, Ruderfer DM, Oh EC, Topol A, Shah HR, Klei LL, Kramer R, Pinto D, Gümüş ZH, Cicek AE, ... ... Schadt EE, et al. Gene expression elucidates functional impact of polygenic risk for schizophrenia. Nature Neuroscience. PMID 27668389 DOI: 10.1038/Nn.4399  0.333
2016 Yang J, Huang T, Song WM, Petralia F, Mobbs CV, Zhang B, Zhao Y, Schadt EE, Zhu J, Tu Z. Discover the network mechanisms underlying the connections between aging and age-related diseases. Scientific Reports. 6: 32566. PMID 27582315 DOI: 10.1038/Srep32566  0.311
2016 Miller CL, Pjanic M, Wang T, Nguyen T, Cohain A, Lee JD, Perisic L, Hedin U, Kundu RK, Majmudar D, Kim JB, Wang O, Betsholtz C, Ruusalepp A, Franzén O, ... ... Schadt EE, et al. Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci. Nature Communications. 7: 12092. PMID 27386823 DOI: 10.1038/Ncomms12092  0.373
2016 Di Narzo AF, Peters LA, Argmann C, Stojmirovic A, Perrigoue J, Li K, Telesco S, Kidd B, Walker J, Dudley J, Cho J, Schadt EE, Kasarskis A, Curran M, Dobrin R, et al. Blood and Intestine eQTLs from an Anti-TNF-Resistant Crohn's Disease Cohort Inform IBD Genetic Association Loci. Clinical and Translational Gastroenterology. 7: e177. PMID 27336838 DOI: 10.1038/Ctg.2016.34  0.368
2016 Glicksberg BS, Li L, Badgeley MA, Shameer K, Kosoy R, Beckmann ND, Pho N, Hakenberg J, Ma M, Ayers KL, Hoffman GE, Dan Li S, Schadt EE, Patel CJ, Chen R, et al. Comparative analyses of population-scale phenomic data in electronic medical records reveal race-specific disease networks. Bioinformatics (Oxford, England). 32: i101-i110. PMID 27307606 DOI: 10.1093/Bioinformatics/Btw282  0.668
2016 Zook JM, Catoe D, McDaniel J, Vang L, Spies N, Sidow A, Weng Z, Liu Y, Mason CE, Alexander N, Henaff E, McIntyre AB, Chandramohan D, Chen F, Jaeger E, ... ... Schadt E, et al. Extensive sequencing of seven human genomes to characterize benchmark reference materials. Scientific Data. 3: 160025. PMID 27271295 DOI: 10.1038/Sdata.2016.25  0.313
2016 Talukdar HA, Foroughi Asl H, Jain RK, Ermel R, Ruusalepp A, Franzén O, Kidd BA, Readhead B, Giannarelli C, Kovacic JC, Ivert T, Dudley JT, Civelek M, Lusis AJ, Schadt EE, et al. Cross-Tissue Regulatory Gene Networks in Coronary Artery Disease. Cell Systems. 2: 196-208. PMID 27135365 DOI: 10.1016/J.Cels.2016.02.002  0.393
2016 Rykunov D, Beckmann ND, Li H, Uzilov A, Schadt EE, Reva B. A new molecular signature method for prediction of driver cancer pathways from transcriptional data. Nucleic Acids Research. PMID 27098033 DOI: 10.1093/Nar/Gkw269  0.301
2016 Li Q, Lee CH, Peters LA, Mastropaolo LA, Thoeni C, Elkadri A, Schwerd T, Zhu J, Zhang B, Zhao Y, Hao K, Dinarzo A, Hoffman G, Kidd BA, Murchie R, ... ... Schadt EE, et al. Variants in TRIM22 that Affect NOD2 Signaling Are Associated With Very Early Onset Inflammatory Bowel Disease. Gastroenterology. PMID 26836588 DOI: 10.1053/J.Gastro.2016.01.031  0.31
2016 Lu Y, Day FR, Gustafsson S, Buchkovich ML, Na J, Bataille V, Cousminer DL, Dastani Z, Drong AW, Esko T, Evans DM, Falchi M, Feitosa MF, Ferreira T, Hedman ÅK, ... ... Schadt EE, et al. New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Nature Communications. 7: 10495. PMID 26833246 DOI: 10.1038/Ncomms10495  0.484
2016 Kilpeläinen TO, Carli JF, Skowronski AA, Sun Q, Kriebel J, Feitosa MF, Hedman ÅK, Drong AW, Hayes JE, Zhao J, Pers TH, Schick U, Grarup N, Kutalik Z, Trompet S, ... ... Schadt EE, et al. Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels. Nature Communications. 7: 10494. PMID 26833098 DOI: 10.1038/Ncomms10494  0.35
2016 Yang J, Huang T, Petralia F, Long Q, Zhang B, Argmann C, Zhao Y, Mobbs CV, Schadt EE, Zhu J, Tu Z. Corrigendum: Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases. Scientific Reports. 6: 19384. PMID 26795431 DOI: 10.1038/Srep19384  0.3
2016 Rozehnal JM, Posner MR, Ang C, Bangi E, Yeykal C, Cagan RL, Dang RP, Donovan M, Uzilov AV, Antipin Y, Schadt EE, Misiukiewicz K. Transgenic drosophila as a drug-screening platform in colorectal cancer and medullary thyroid cancer. Journal of Clinical Oncology. 34: e23164-e23164. DOI: 10.1200/Jco.2016.34.15_Suppl.E23164  0.307
2016 Zhang B, McKenzie A, Wang M, Katsyv I, Song W, Zhou X, Popko B, Aaker J, Tredici K, Nave K, Zhu J, Schadt E, Casaccia P. F2-01-01: Oligodendrocyte-Enriched Gene Networks Reveal Novel Pathways and Key Targets in the Pathogenesis of Alzheimer’s Disease Alzheimer's & Dementia. 12: P214-P214. DOI: 10.1016/J.Jalz.2016.06.380  0.308
2015 Argmann CA, Houten SM, Zhu J, Schadt EE. A Next Generation Multiscale View of Inborn Errors of Metabolism. Cell Metabolism. PMID 26712461 DOI: 10.1016/J.Cmet.2015.11.012  0.336
2015 Dincer A, Gavin DP, Xu K, Zhang B, Dudley JT, Schadt EE, Akbarian S. Deciphering H3K4me3 broad domains associated with gene-regulatory networks and conserved epigenomic landscapes in the human brain. Translational Psychiatry. 5: e679. PMID 26575220 DOI: 10.1038/Tp.2015.169  0.307
2015 Readhead B, Haure-Mirande JV, Zhang B, Haroutunian V, Gandy S, Schadt EE, Dudley JT, Ehrlich ME. Molecular systems evaluation of oligomerogenic APP(E693Q) and fibrillogenic APP(KM670/671NL)/PSEN1(Δexon9) mouse models identifies shared features with human Alzheimer's brain molecular pathology. Molecular Psychiatry. PMID 26552589 DOI: 10.1038/Mp.2015.167  0.328
2015 Sudmant PH, Rausch T, Gardner EJ, Handsaker RE, Abyzov A, Huddleston J, Zhang Y, Ye K, Jun G, Hsi-Yang Fritz M, Konkel MK, Malhotra A, Stütz AM, Shi X, Paolo Casale F, ... ... Schadt EE, et al. An integrated map of structural variation in 2,504 human genomes. Nature. 526: 75-81. PMID 26432246 DOI: 10.1038/Nature15394  0.39
2015 Wang L, Gong Y, Chippada-Venkata U, Heck MM, Retz M, Nawroth R, Galsky M, Tsao CK, Schadt E, de Bono J, Olmos D, Zhu J, Oh WK. A robust blood gene expression-based prognostic model for castration-resistant prostate cancer. Bmc Medicine. 13: 201. PMID 26297150 DOI: 10.1186/S12916-015-0442-0  0.364
2015 Brænne I, Civelek M, Vilne B, Di Narzo A, Johnson AD, Zhao Y, Reiz B, Codoni V, Webb TR, Foroughi Asl H, Hamby SE, Zeng L, Trégouët DA, Hao K, Topol EJ, ... Schadt EE, et al. Prediction of Causal Candidate Genes in Coronary Artery Disease Loci. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 26293461 DOI: 10.1161/Atvbaha.115.306108  0.336
2015 Pendleton M, Sebra R, Pang AW, Ummat A, Franzen O, Rausch T, Stütz AM, Stedman W, Anantharaman T, Hastie A, Dai H, Fritz MH, Cao H, Cohain A, Deikus G, ... ... Schadt EE, et al. Assembly and diploid architecture of an individual human genome via single-molecule technologies. Nature Methods. PMID 26121404 DOI: 10.1038/Nmeth.3454  0.312
2015 Ning K, Gettler K, Zhang W, Ng SM, Bowen BM, Hyams J, Stephens MC, Kugathasan S, Denson LA, Schadt EE, Hoffman GE, Cho JH. Improved integrative framework combining association data with gene expression features to prioritize Crohn's disease genes. Human Molecular Genetics. 24: 4147-57. PMID 25935003 DOI: 10.1093/Hmg/Ddv142  0.378
2015 Björkegren JL, Kovacic JC, Dudley JT, Schadt EE. Genome-wide significant loci: how important are they? Systems genetics to understand heritability of coronary artery disease and other common complex disorders. Journal of the American College of Cardiology. 65: 830-45. PMID 25720628 DOI: 10.1016/J.Jacc.2014.12.033  0.365
2015 Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, Powell C, Vedantam S, Buchkovich ML, Yang J, Croteau-Chonka DC, Esko T, Fall T, Ferreira T, Gustafsson S, ... ... Schadt EE, et al. Genetic studies of body mass index yield new insights for obesity biology. Nature. 518: 197-206. PMID 25673413 DOI: 10.1038/Nature14177  0.51
2015 Shungin D, Winkler TW, Croteau-Chonka DC, Ferreira T, Locke AE, Mägi R, Strawbridge RJ, Pers TH, Fischer K, Justice AE, Workalemahu T, Wu JM, Buchkovich ML, Heard-Costa NL, Roman TS, ... ... Schadt EE, et al. New genetic loci link adipose and insulin biology to body fat distribution. Nature. 518: 187-96. PMID 25673412 DOI: 10.1038/Nature14132  0.532
2015 Foroughi Asl H, Talukdar HA, Kindt AS, Jain RK, Ermel R, Ruusalepp A, Nguyen KD, Dobrin R, Reilly DF, Schunkert H, Samani NJ, Braenne I, Erdmann J, Melander O, Qi J, ... ... Schadt EE, et al. Expression quantitative trait Loci acting across multiple tissues are enriched in inherited risk for coronary artery disease. Circulation. Cardiovascular Genetics. 8: 305-15. PMID 25578447 DOI: 10.1161/Circgenetics.114.000640  0.312
2015 Yoo S, Takikawa S, Geraghty P, Argmann C, Campbell J, Lin L, Huang T, Tu Z, Foronjy RF, Feronjy R, Spira A, Schadt EE, Powell CA, Zhu J. Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD. Plos Genetics. 11: e1004898. PMID 25569234 DOI: 10.1371/Journal.Pgen.1004898  0.378
2015 Bunyavanich S, Schadt EE. Systems biology of asthma and allergic diseases: a multiscale approach. The Journal of Allergy and Clinical Immunology. 135: 31-42. PMID 25468194 DOI: 10.1016/J.Jaci.2014.10.015  0.32
2015 Ferguson JF, Meyer NJ, Qu L, Xue C, Liu Y, DerOhannessian SL, Rushefski M, Paschos GK, Tang S, Schadt EE, Li M, Christie JD, Reilly MP. Integrative genomics identifies 7p11.2 as a novel locus for fever and clinical stress response in humans. Human Molecular Genetics. 24: 1801-12. PMID 25416278 DOI: 10.1093/Hmg/Ddu589  0.383
2015 Perumal D, Lagana' A, Rubinsteyn A, Finnigan JP, Kuo P, Leshchenko VV, Chari A, Cho HJ, Jagannath S, Dudley J, Hammerbacher J, Schadt E, Bhardwaj N, Parekh S. Patient-Specific Mutation-Derived Tumor Antigens As Targets for Cancer Immunotherapy in Multiple Myeloma Blood. 126: 1851-1851. DOI: 10.1182/Blood.V126.23.1851.1851  0.326
2014 Schadt EE, Buchanan S, Brennand KJ, Merchant KM. Evolving toward a human-cell based and multiscale approach to drug discovery for CNS disorders. Frontiers in Pharmacology. 5: 252. PMID 25520658 DOI: 10.3389/Fphar.2014.00252  0.339
2014 Roussos P, Mitchell AC, Voloudakis G, Fullard JF, Pothula VM, Tsang J, Stahl EA, Georgakopoulos A, Ruderfer DM, Charney A, Okada Y, Siminovitch KA, Worthington J, Padyukov L, Klareskog L, ... ... Schadt EE, et al. A role for noncoding variation in schizophrenia. Cell Reports. 9: 1417-29. PMID 25453756 DOI: 10.1016/J.Celrep.2014.10.015  0.328
2014 Neylan TC, Schadt EE, Yehuda R. Biomarkers for combat-related PTSD: focus on molecular networks from high-dimensional data. European Journal of Psychotraumatology. 5. PMID 25206954 DOI: 10.3402/Ejpt.V5.23938  0.318
2014 Yoo S, Huang T, Campbell JD, Lee E, Tu Z, Geraci MW, Powell CA, Schadt EE, Spira A, Zhu J. MODMatcher: multi-omics data matcher for integrative genomic analysis. Plos Computational Biology. 10: e1003790. PMID 25122495 DOI: 10.1371/Journal.Pcbi.1003790  0.358
2014 Bunyavanich S, Schadt EE, Himes BE, Lasky-Su J, Qiu W, Lazarus R, Ziniti JP, Cohain A, Linderman M, Torgerson DG, Eng CS, Pino-Yanes M, Padhukasahasram B, Yang JJ, Mathias RA, et al. Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis. Bmc Medical Genomics. 7: 48. PMID 25085501 DOI: 10.1186/1755-8794-7-48  0.422
2014 Hoffman GE, Mezey JG, Schadt EE. lrgpr: interactive linear mixed model analysis of genome-wide association studies with composite hypothesis testing and regression diagnostics in R. Bioinformatics (Oxford, England). 30: 3134-5. PMID 25035399 DOI: 10.1093/Bioinformatics/Btu435  0.312
2014 Shang MM, Talukdar HA, Hofmann JJ, Niaudet C, Asl HF, Jain RK, Rossignoli A, Cedergren C, Silveira A, Gigante B, Leander K, de Faire U, Hamsten A, Ruusalepp A, Melander O, ... ... Schadt EE, et al. Lim domain binding 2: a key driver of transendothelial migration of leukocytes and atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 34: 2068-77. PMID 24925974 DOI: 10.1161/Atvbaha.113.302709  0.36
2014 Friend SH, Schadt EE. Translational genomics. Clues from the resilient. Science (New York, N.Y.). 344: 970-2. PMID 24876479 DOI: 10.1126/Science.1255648  0.335
2014 Giambartolomei C, Vukcevic D, Schadt EE, Franke L, Hingorani AD, Wallace C, Plagnol V. Bayesian test for colocalisation between pairs of genetic association studies using summary statistics. Plos Genetics. 10: e1004383. PMID 24830394 DOI: 10.1371/Journal.Pgen.1004383  0.427
2014 Tragante V, Barnes MR, Ganesh SK, Lanktree MB, Guo W, Franceschini N, Smith EN, Johnson T, Holmes MV, Padmanabhan S, Karczewski KJ, Almoguera B, Barnard J, Baumert J, Chang YP, ... ... Schadt EE, et al. Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci. American Journal of Human Genetics. 94: 349-60. PMID 24560520 DOI: 10.1016/J.Ajhg.2013.12.016  0.366
2014 Kojima Y, Downing K, Kundu R, Miller C, Dewey F, Lancero H, Raaz U, Perisic L, Hedin U, Schadt E, Maegdefessel L, Quertermous T, Leeper NJ. Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis. The Journal of Clinical Investigation. 124: 1083-97. PMID 24531546 DOI: 10.1172/Jci70391  0.333
2014 Sivendran S, Chang R, Pham L, Phelps RG, Harcharik ST, Hall LD, Bernardo SG, Moskalenko MM, Sivendran M, Fu Y, de Moll EH, Pan M, Moon JY, Arora S, Cohain A, ... ... Schadt EE, et al. Dissection of immune gene networks in primary melanoma tumors critical for antitumor surveillance of patients with stage II-III resectable disease. The Journal of Investigative Dermatology. 134: 2202-11. PMID 24522433 DOI: 10.1038/Jid.2014.85  0.346
2014 Dai X, Gong Y, Galsky MD, Schadt EE, Oh WK, Zhu J. Abstract 368: Inferred regulatory interaction network from prostate cancer reveals potential regulators coordinating progression and metastasis Cancer Research. 74: 368-368. DOI: 10.1158/1538-7445.Am2014-368  0.301
2014 Hao K, Di Narzo A, Chen J, Dudley J, Horowitz N, Schadt E, Lambertini L, Landrigan P, Aagaard K, Hobbs C, Varner M, Dole N, Culhane J, Swanson J, Thiex N, et al. Expression quantitative trait loci in placenta tissues from the national children’s study reveal developmental origins of human complex diseases Placenta. 35: A49. DOI: 10.1016/J.Placenta.2014.06.161  0.318
2013 Au KF, Sebastiano V, Afshar PT, Durruthy JD, Lee L, Williams BA, van Bakel H, Schadt EE, Reijo-Pera RA, Underwood JG, Wong WH. Characterization of the human ESC transcriptome by hybrid sequencing. Proceedings of the National Academy of Sciences of the United States of America. 110: E4821-30. PMID 24282307 DOI: 10.1073/Pnas.1320101110  0.333
2013 Trabzuni D, Ryten M, Emmett W, Ramasamy A, Lackner KJ, Zeller T, Walker R, Smith C, Lewis PA, Mamais A, de Silva R, Vandrovcova J, Hernandez D, Nalls MA, ... ... Schadt E, et al. Fine-mapping, gene expression and splicing analysis of the disease associated LRRK2 locus. Plos One. 8: e70724. PMID 23967090 DOI: 10.1371/Journal.Pone.0070724  0.33
2013 Miller CL, Anderson DR, Kundu RK, Raiesdana A, Nürnberg ST, Diaz R, Cheng K, Leeper NJ, Chen CH, Chang IS, Schadt EE, Hsiung CA, Assimes TL, Quertermous T. Disease-related growth factor and embryonic signaling pathways modulate an enhancer of TCF21 expression at the 6q23.2 coronary heart disease locus. Plos Genetics. 9: e1003652. PMID 23874238 DOI: 10.1371/Journal.Pgen.1003652  0.328
2013 Zhang B, Gaiteri C, Bodea LG, Wang Z, McElwee J, Podtelezhnikov AA, Zhang C, Xie T, Tran L, Dobrin R, Fluder E, Clurman B, Melquist S, Narayanan M, Suver C, ... ... Schadt EE, et al. Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease. Cell. 153: 707-20. PMID 23622250 DOI: 10.1016/J.Cell.2013.03.030  0.33
2013 Monda KL, Chen GK, Taylor KC, Palmer C, Edwards TL, Lange LA, Ng MC, Adeyemo AA, Allison MA, Bielak LF, Chen G, Graff M, Irvin MR, Rhie SK, Li G, ... ... Schadt EE, et al. A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nature Genetics. 45: 690-6. PMID 23583978 DOI: 10.1038/Ng.2608  0.51
2013 Berndt SI, Gustafsson S, Mägi R, Ganna A, Wheeler E, Feitosa MF, Justice AE, Monda KL, Croteau-Chonka DC, Day FR, Esko T, Fall T, Ferreira T, Gentilini D, Jackson AU, ... ... Schadt EE, et al. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nature Genetics. 45: 501-12. PMID 23563607 DOI: 10.1038/Ng.2606  0.537
2013 Gandy S, Haroutunian V, DeKosky ST, Sano M, Schadt EE. CR1 and the "vanishing amyloid" hypothesis of Alzheimer's disease. Biological Psychiatry. 73: 393-5. PMID 23399469 DOI: 10.1016/J.Biopsych.2013.01.013  0.309
2013 Ganesh SK, Tragante V, Guo W, Guo Y, Lanktree MB, Smith EN, Johnson T, Castillo BA, Barnard J, Baumert J, Chang YP, Elbers CC, Farrall M, Fischer ME, Franceschini N, ... ... Schadt EE, et al. Loci influencing blood pressure identified using a cardiovascular gene-centric array. Human Molecular Genetics. 22: 1663-78. PMID 23303523 DOI: 10.1093/Hmg/Dds555  0.349
2013 Lluch-Senar M, Luong K, Lloréns-Rico V, Delgado J, Fang G, Spittle K, Clark TA, Schadt E, Turner SW, Korlach J, Serrano L. Comprehensive methylome characterization of Mycoplasma genitalium and Mycoplasma pneumoniae at single-base resolution. Plos Genetics. 9: e1003191. PMID 23300489 DOI: 10.1371/Journal.Pgen.1003191  0.31
2013 Deloukas P, Kanoni S, Willenborg C, Farrall M, Assimes TL, Thompson JR, Ingelsson E, Saleheen D, Erdmann J, Goldstein BA, Stirrups K, König IR, Cazier JB, Johansson A, ... ... Schadt E, et al. Large-scale association analysis identifies new risk loci for coronary artery disease. Nature Genetics. 45: 25-33. PMID 23202125 DOI: 10.1038/Ng.2480  0.564
2013 Leeper NJ, Raiesdana A, Kojima Y, Kundu RK, Cheng H, Maegdefessel L, Toh R, Ahn GO, Ali ZA, Anderson DR, Miller CL, Roberts SC, Spin JM, de Almeida PE, Wu JC, ... ... Schadt EE, et al. Loss of CDKN2B promotes p53-dependent smooth muscle cell apoptosis and aneurysm formation. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: e1-e10. PMID 23162013 DOI: 10.1161/Atvbaha.112.300399  0.327
2012 Tu Z, Keller MP, Zhang C, Rabaglia ME, Greenawalt DM, Yang X, Wang IM, Dai H, Bruss MD, Lum PY, Zhou YP, Kemp DM, Kendziorski C, Yandell BS, Attie AD, ... Schadt EE, et al. Integrative analysis of a cross-loci regulation network identifies App as a gene regulating insulin secretion from pancreatic islets. Plos Genetics. 8: e1003107. PMID 23236292 DOI: 10.1371/Journal.Pgen.1003107  0.359
2012 van der Harst P, Zhang W, Mateo Leach I, Rendon A, Verweij N, Sehmi J, Paul DS, Elling U, Allayee H, Li X, Radhakrishnan A, Tan ST, Voss K, Weichenberger CX, Albers CA, ... ... Schadt E, et al. Seventy-five genetic loci influencing the human red blood cell. Nature. 492: 369-75. PMID 23222517 DOI: 10.1038/Nature11677  0.356
2012 Fang G, Munera D, Friedman DI, Mandlik A, Chao MC, Banerjee O, Feng Z, Losic B, Mahajan MC, Jabado OJ, Deikus G, Clark TA, Luong K, Murray IA, Davis BM, ... ... Schadt EE, et al. Genome-wide mapping of methylated adenine residues in pathogenic Escherichia coli using single-molecule real-time sequencing. Nature Biotechnology. 30: 1232-9. PMID 23138224 DOI: 10.1038/Nbt.2432  0.302
2012 Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, Lee JC, Schumm LP, Sharma Y, Anderson CA, Essers J, Mitrovic M, Ning K, Cleynen I, Theatre E, ... ... Schadt EE, et al. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature. 491: 119-24. PMID 23128233 DOI: 10.1038/Nature11582  0.376
2012 Schwartz SM, Schwartz HT, Horvath S, Schadt E, Lee SI. A systematic approach to multifactorial cardiovascular disease: causal analysis. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 2821-35. PMID 23087359 DOI: 10.1161/Atvbaha.112.300123  0.308
2012 Loos RJ, Schadt EE. This I believe: gaining new insights through integrating "old" data. Frontiers in Genetics. 3: 137. PMID 23024647 DOI: 10.3389/Fgene.2012.00137  0.355
2012 Schadt E, Chang R. Genetics. A GPS for navigating DNA. Science (New York, N.Y.). 337: 1179-80. PMID 22955822 DOI: 10.1126/Science.1227739  0.369
2012 Grundberg E, Small KS, Hedman Ã…K, Nica AC, Buil A, Keildson S, Bell JT, Yang TP, Meduri E, Barrett A, Nisbett J, Sekowska M, Wilk A, Shin SY, Glass D, ... ... Schadt EE, et al. Mapping cis- and trans-regulatory effects across multiple tissues in twins. Nature Genetics. 44: 1084-9. PMID 22941192 DOI: 10.1038/Ng.2394  0.367
2012 Lo K, Raftery AE, Dombek KM, Zhu J, Schadt EE, Bumgarner RE, Yeung KY. Integrating external biological knowledge in the construction of regulatory networks from time-series expression data. Bmc Systems Biology. 6: 101. PMID 22898396 DOI: 10.1186/1752-0509-6-101  0.323
2012 Wang IM, Zhang B, Yang X, Zhu J, Stepaniants S, Zhang C, Meng Q, Peters M, He Y, Ni C, Slipetz D, Crackower MA, Houshyar H, Tan CM, Asante-Appiah E, ... ... Schadt EE, et al. Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers. Molecular Systems Biology. 8: 594. PMID 22806142 DOI: 10.1038/Msb.2012.24  0.385
2012 Wang CY, Stapleton DS, Schueler KL, Rabaglia ME, Oler AT, Keller MP, Kendziorski CM, Broman KW, Yandell BS, Schadt EE, Attie AD. Tsc2, a positional candidate gene underlying a quantitative trait locus for hepatic steatosis. Journal of Lipid Research. 53: 1493-501. PMID 22628617 DOI: 10.1194/Jlr.M025239  0.353
2012 Kang HP, Yang X, Chen R, Zhang B, Corona E, Schadt EE, Butte AJ. Integration of disease-specific single nucleotide polymorphisms, expression quantitative trait loci and coexpression networks reveal novel candidate genes for type 2 diabetes. Diabetologia. 55: 2205-13. PMID 22584726 DOI: 10.1007/S00125-012-2568-3  0.383
2012 Zhu J, Sova P, Xu Q, Dombek KM, Xu EY, Vu H, Tu Z, Brem RB, Bumgarner RE, Schadt EE. Stitching together multiple data dimensions reveals interacting metabolomic and transcriptomic networks that modulate cell regulation. Plos Biology. 10: e1001301. PMID 22509135 DOI: 10.1371/Journal.Pbio.1001301  0.341
2012 Schadt EE, Woo S, Hao K. Bayesian method to predict individual SNP genotypes from gene expression data. Nature Genetics. 44: 603-8. PMID 22484626 DOI: 10.1038/Ng.2248  0.321
2012 Dastani Z, Hivert MF, Timpson N, Perry JR, Yuan X, Scott RA, Henneman P, Heid IM, Kizer JR, Lyytikäinen LP, Fuchsberger C, Tanaka T, Morris AP, Small K, Isaacs A, ... ... Schadt EE, et al. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. Plos Genetics. 8: e1002607. PMID 22479202 DOI: 10.1371/Journal.Pgen.1002607  0.514
2012 Salm MP, Horswell SD, Hutchison CE, Speedy HE, Yang X, Liang L, Schadt EE, Cookson WO, Wierzbicki AS, Naoumova RP, Shoulders CC. The origin, global distribution, and functional impact of the human 8p23 inversion polymorphism. Genome Research. 22: 1144-53. PMID 22399572 DOI: 10.1101/Gr.126037.111  0.387
2012 Casellas J, Gularte RJ, Farber CR, Varona L, Mehrabian M, Schadt EE, Lusis AJ, Attie AD, Yandell BS, Medrano JF. Genome scans for transmission ratio distortion regions in mice. Genetics. 191: 247-59. PMID 22367040 DOI: 10.1534/Genetics.111.135988  0.347
2012 Saxena R, Elbers CC, Guo Y, Peter I, Gaunt TR, Mega JL, Lanktree MB, Tare A, Castillo BA, Li YR, Johnson T, Bruinenberg M, Gilbert-Diamond D, Rajagopalan R, Voight BF, ... ... Schadt EE, et al. Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. American Journal of Human Genetics. 90: 410-25. PMID 22325160 DOI: 10.1016/J.Ajhg.2011.12.022  0.55
2012 Davis RC, van Nas A, Castellani LW, Zhao Y, Zhou Z, Wen P, Yu S, Qi H, Rosales M, Schadt EE, Broman KW, Péterfy M, Lusis AJ. Systems genetics of susceptibility to obesity-induced diabetes in mice. Physiological Genomics. 44: 1-13. PMID 22010005 DOI: 10.1152/Physiolgenomics.00003.2011  0.321
2012 Langfelder P, Castellani LW, Zhou Z, Paul E, Davis R, Schadt EE, Lusis AJ, Horvath S, Mehrabian M. A systems genetic analysis of high density lipoprotein metabolism and network preservation across mouse models. Biochimica Et Biophysica Acta. 1821: 435-47. PMID 21807117 DOI: 10.1016/J.Bbalip.2011.07.014  0.369
2012 Lanktree M, Guo Y, Murtaza M, Glessner J, Bailey S, Onland-Moret N, Lettre G, Ongen H, Rajagopalan R, Johnson T, Shen H, Nelson C, Klopp N, Baumert J, Padmanabhan S, ... ... Schadt E, et al. Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height The American Journal of Human Genetics. 90: 1116-1117. DOI: 10.1016/J.Ajhg.2012.05.017  0.304
2012 Saxena R, Elbers C, Guo Y, Peter I, Gaunt T, Mega J, Lanktree M, Tare A, Castillo B, Li Y, Johnson T, Bruinenberg M, Gilbert-Diamond D, Rajagopalan R, Voight B, ... ... Schadt E, et al. Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci The American Journal of Human Genetics. 90: 753. DOI: 10.1016/J.Ajhg.2012.03.001  0.496
2011 Kasarskis A, Yang X, Schadt E. Integrative genomics strategies to elucidate the complexity of drug response Pharmacogenomics. 12: 1695-1715. PMID 22118053 DOI: 10.2217/Pgs.11.115  0.394
2011 Yeung KY, Dombek KM, Lo K, Mittler JE, Zhu J, Schadt EE, Bumgarner RE, Raftery AE. Construction of regulatory networks using expression time-series data of a genotyped population. Proceedings of the National Academy of Sciences of the United States of America. 108: 19436-41. PMID 22084118 DOI: 10.1073/Pnas.1116442108  0.362
2011 Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, Van der Harst P, Holm H, Sanna S, Kavousi M, Baumeister SE, Coin LJ, Deng G, Gieger C, Heard-Costa NL, Hottenga JJ, ... ... Schadt EE, et al. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nature Genetics. 43: 1131-8. PMID 22001757 DOI: 10.1038/Ng.970  0.363
2011 Dobrin R, Greenawalt DM, Hu G, Kemp DM, Kaplan LM, Schadt EE, Emilsson V. Dissecting cis regulation of gene expression in human metabolic tissues. Plos One. 6: e23480. PMID 21912597 DOI: 10.1371/Journal.Pone.0023480  0.352
2011 Tran LM, Zhang B, Zhang Z, Zhang C, Xie T, Lamb JR, Dai H, Schadt EE, Zhu J. Inferring causal genomic alterations in breast cancer using gene expression data. Bmc Systems Biology. 5: 121. PMID 21806811 DOI: 10.1186/1752-0509-5-121  0.384
2011 Lamb JR, Zhang C, Xie T, Wang K, Zhang B, Hao K, Chudin E, Fraser HB, Millstein J, Ferguson M, Suver C, Ivanovska I, Scott M, Philippar U, Bansal D, ... ... Schadt EE, et al. Predictive genes in adjacent normal tissue are preferentially altered by sCNV during tumorigenesis in liver cancer and may rate limiting. Plos One. 6: e20090. PMID 21750698 DOI: 10.1371/Journal.Pone.0020090  0.329
2011 Kilpeläinen TO, Zillikens MC, Stančákova A, Finucane FM, Ried JS, Langenberg C, Zhang W, Beckmann JS, Luan J, Vandenput L, Styrkarsdottir U, Zhou Y, Smith AV, Zhao JH, Amin N, ... ... Schadt E, et al. Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nature Genetics. 43: 753-60. PMID 21706003 DOI: 10.1038/Ng.866  0.345
2011 Su WL, Kleinhanz RR, Schadt EE. Characterizing the role of miRNAs within gene regulatory networks using integrative genomics techniques. Molecular Systems Biology. 7: 490. PMID 21613979 DOI: 10.1038/Msb.2011.23  0.305
2011 Greenawalt DM, Dobrin R, Chudin E, Hatoum IJ, Suver C, Beaulaurier J, Zhang B, Castro V, Zhu J, Sieberts SK, Wang S, Molony C, Heymsfield SB, Kemp DM, Reitman ML, ... ... Schadt EE, et al. A survey of the genetics of stomach, liver, and adipose gene expression from a morbidly obese cohort. Genome Research. 21: 1008-16. PMID 21602305 DOI: 10.1101/Gr.112821.110  0.399
2011 Fraser HB, Babak T, Tsang J, Zhou Y, Zhang B, Mehrabian M, Schadt EE. Systematic detection of polygenic cis-regulatory evolution. Plos Genetics. 7: e1002023. PMID 21483757 DOI: 10.1371/Journal.Pgen.1002023  0.354
2011 Speliotes EK, Yerges-Armstrong LM, Wu J, Hernaez R, Kim LJ, Palmer CD, Gudnason V, Eiriksdottir G, Garcia ME, Launer LJ, Nalls MA, Clark JM, Mitchell BD, Shuldiner AR, Butler JL, ... ... Schadt EE, et al. Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. Plos Genetics. 7: e1001324. PMID 21423719 DOI: 10.1371/Journal.Pgen.1001324  0.36
2011 Ma H, Schadt EE, Kaplan LM, Zhao H. COSINE: COndition-SpecIfic sub-NEtwork identification using a global optimization method. Bioinformatics (Oxford, England). 27: 1290-8. PMID 21414987 DOI: 10.1093/Bioinformatics/Btr136  0.343
2011 Schunkert H, König IR, Kathiresan S, Reilly MP, Assimes TL, Holm H, Preuss M, Stewart AF, Barbalic M, Gieger C, Absher D, Aherrahrou Z, Allayee H, Altshuler D, Anand SS, ... ... Schadt E, et al. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nature Genetics. 43: 333-8. PMID 21378990 DOI: 10.1038/Ng.784  0.343
2011 O'Brien TR, Kohaar I, Pfeiffer RM, Maeder D, Yeager M, Schadt EE, Prokunina-Olsson L. Risk alleles for chronic hepatitis B are associated with decreased mRNA expression of HLA-DPA1 and HLA-DPB1 in normal human liver. Genes and Immunity. 12: 428-33. PMID 21346778 DOI: 10.1038/Gene.2011.11  0.321
2011 Schadt E. First Steps on a Long Road Science. 331: 691-691. PMID 21310999 DOI: 10.1126/Science.1203235  0.392
2011 Pichler I, Minelli C, Sanna S, Tanaka T, Schwienbacher C, Naitza S, Porcu E, Pattaro C, Busonero F, Zanon A, Maschio A, Melville SA, Grazia Piras M, Longo DL, Guralnik J, ... ... Schadt E, et al. Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels. Human Molecular Genetics. 20: 1232-40. PMID 21208937 DOI: 10.1093/Hmg/Ddq552  0.35
2011 Lanktree MB, Guo Y, Murtaza M, Glessner JT, Bailey SD, Onland-Moret NC, Lettre G, Ongen H, Rajagopalan R, Johnson T, Shen H, Nelson CP, Klopp N, Baumert J, Padmanabhan S, ... ... Schadt EE, et al. Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. American Journal of Human Genetics. 88: 6-18. PMID 21194676 DOI: 10.1016/J.Ajhg.2010.11.007  0.359
2011 Wang P, Dawson JA, Keller MP, Yandell BS, Thornberry NA, Zhang BB, Wang IM, Schadt EE, Attie AD, Kendziorski C. A model selection approach for expression quantitative trait loci (eQTL) mapping. Genetics. 187: 611-21. PMID 21115971 DOI: 10.1534/Genetics.110.122796  0.329
2011 Zhang B, Derry J, Schadt E, Friend S, Zhu J, Dai X, Wang Z, Meng F, Tran L, Zhang Z, Guinney J, Clurman B, Wu G. Abstract PR8: From prediction to prognosis and therapeutics: The power of breast cancer transcriptional networks Cancer Research. 71. DOI: 10.1158/1538-7445.Fbcr11-Pr8  0.334
2011 Califano A, Butte A, Friend S, Ideker T, Schadt EE. Integrative Network-based Association Studies: Leveraging cell regulatory models in the post-GWAS era Nature Precedings. DOI: 10.1038/Npre.2011.5732.1  0.424
2011 Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, Steinthorsdottir V, Thorleifsson G, Zillikens MC, Speliotes EK, Mägi R, Workalemahu T, White CC, Bouatia-Naji N, Harris TB, Berndt SI, ... ... Schadt EE, et al. Erratum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution Nature Genetics. 43: 1164-1164. DOI: 10.1038/Ng1111-1164A  0.5
2010 Derry JM, Zhong H, Molony C, MacNeil D, Guhathakurta D, Zhang B, Mudgett J, Small K, El Fertak L, Guimond A, Selloum M, Zhao W, Champy MF, Monassier L, Vogt T, ... ... Schadt EE, et al. Identification of genes and networks driving cardiovascular and metabolic phenotypes in a mouse F2 intercross. Plos One. 5: e14319. PMID 21179467 DOI: 10.1371/Journal.Pone.0014319  0.393
2010 Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Lango Allen H, Lindgren CM, Luan J, Mägi R, Randall JC, Vedantam S, Winkler TW, Qi L, Workalemahu T, ... ... Schadt EE, et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nature Genetics. 42: 937-48. PMID 20935630 DOI: 10.1038/Ng.686  0.533
2010 Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, Steinthorsdottir V, Thorleifsson G, Zillikens MC, Speliotes EK, Mägi R, Workalemahu T, White CC, Bouatia-Naji N, Harris TB, Berndt SI, ... ... Schadt EE, et al. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nature Genetics. 42: 949-60. PMID 20935629 DOI: 10.1038/Ng.685  0.462
2010 Lango Allen H, Estrada K, Lettre G, Berndt SI, Weedon MN, Rivadeneira F, Willer CJ, Jackson AU, Vedantam S, Raychaudhuri S, Ferreira T, Wood AR, Weyant RJ, Segrè AV, Speliotes EK, ... ... Schadt EE, et al. Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature. 467: 832-8. PMID 20881960 DOI: 10.1038/Nature09410  0.585
2010 Pandey G, Zhang B, Chang AN, Myers CL, Zhu J, Kumar V, Schadt EE. An integrative multi-network and multi-classifier approach to predict genetic interactions. Plos Computational Biology. 6. PMID 20838583 DOI: 10.1371/Journal.Pcbi.1000928  0.34
2010 Listgarten J, Kadie C, Schadt EE, Heckerman D. Correction for hidden confounders in the genetic analysis of gene expression. Proceedings of the National Academy of Sciences of the United States of America. 107: 16465-70. PMID 20810919 DOI: 10.1073/Pnas.1002425107  0.404
2010 Babak T, Garrett-Engele P, Armour CD, Raymond CK, Keller MP, Chen R, Rohl CA, Johnson JM, Attie AD, Fraser HB, Schadt EE. Genetic validation of whole-transcriptome sequencing for mapping expression affected by cis-regulatory variation. Bmc Genomics. 11: 473. PMID 20707912 DOI: 10.1186/1471-2164-11-473  0.386
2010 Musunuru K, Strong A, Frank-Kamenetsky M, Lee NE, Ahfeldt T, Sachs KV, Li X, Li H, Kuperwasser N, Ruda VM, Pirruccello JP, Muchmore B, Prokunina-Olsson L, Hall JL, Schadt EE, et al. From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature. 466: 714-9. PMID 20686566 DOI: 10.1038/Nature09266  0.327
2010 Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, Pirruccello JP, Ripatti S, Chasman DI, Willer CJ, Johansen CT, Fouchier SW, Isaacs A, Peloso GM, Barbalic M, ... ... Schadt EE, et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 466: 707-13. PMID 20686565 DOI: 10.1038/Nature09270  0.518
2010 Nilsson EE, Savenkova MI, Schindler R, Zhang B, Schadt EE, Skinner MK. Gene bionetwork analysis of ovarian primordial follicle development. Plos One. 5: e11637. PMID 20661288 DOI: 10.1371/Journal.Pone.0011637  0.349
2010 Vergeer M, Boekholdt SM, Sandhu MS, Ricketts SL, Wareham NJ, Brown MJ, de Faire U, Leander K, Gigante B, Kavousi M, Hofman A, Uitterlinden AG, van Duijn CM, Witteman JC, Jukema JW, ... Schadt EE, et al. Genetic variation at the phospholipid transfer protein locus affects its activity and high-density lipoprotein size and is a novel marker of cardiovascular disease susceptibility. Circulation. 122: 470-7. PMID 20644014 DOI: 10.1161/Circulationaha.109.912519  0.327
2010 Yang X, Peterson L, Thieringer R, Deignan JL, Wang X, Zhu J, Wang S, Zhong H, Stepaniants S, Beaulaurier J, Wang IM, Rosa R, Cumiskey AM, Luo JM, Luo Q, ... ... Schadt EE, et al. Identification and validation of genes affecting aortic lesions in mice. The Journal of Clinical Investigation. 120: 2414-22. PMID 20577049 DOI: 10.1172/Jci42742  0.359
2010 Hsu YH, Zillikens MC, Wilson SG, Farber CR, Demissie S, Soranzo N, Bianchi EN, Grundberg E, Liang L, Richards JB, Estrada K, Zhou Y, van Nas A, Moffatt MF, Zhai G, ... ... Schadt EE, et al. An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits. Plos Genetics. 6: e1000977. PMID 20548944 DOI: 10.1371/Journal.Pgen.1000977  0.409
2010 Yang X, Zhang B, Molony C, Chudin E, Hao K, Zhu J, Gaedigk A, Suver C, Zhong H, Leeder JS, Guengerich FP, Strom SC, Schuetz E, Rushmore TH, Ulrich RG, ... ... Schadt EE, et al. Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver. Genome Research. 20: 1020-36. PMID 20538623 DOI: 10.1101/Gr.103341.109  0.355
2010 Zhong H, Beaulaurier J, Lum PY, Molony C, Yang X, Macneil DJ, Weingarth DT, Zhang B, Greenawalt D, Dobrin R, Hao K, Woo S, Fabre-Suver C, Qian S, Tota MR, ... ... Schadt EE, et al. Liver and adipose expression associated SNPs are enriched for association to type 2 diabetes. Plos Genetics. 6: e1000932. PMID 20463879 DOI: 10.1371/Journal.Pgen.1000932  0.421
2010 van Nas A, Ingram-Drake L, Sinsheimer JS, Wang SS, Schadt EE, Drake T, Lusis AJ. Expression quantitative trait loci: replication, tissue- and sex-specificity in mice. Genetics. 185: 1059-68. PMID 20439777 DOI: 10.1534/Genetics.110.116087  0.349
2010 Narayanan M, Vetta A, Schadt EE, Zhu J. Simultaneous clustering of multiple gene expression and physical interaction datasets. Plos Computational Biology. 6: e1000742. PMID 20419151 DOI: 10.1371/Journal.Pcbi.1000742  0.323
2010 Zhong H, Yang X, Kaplan LM, Molony C, Schadt EE. Integrating pathway analysis and genetics of gene expression for genome-wide association studies. American Journal of Human Genetics. 86: 581-91. PMID 20346437 DOI: 10.1016/J.Ajhg.2010.02.020  0.413
2010 Zhu J, Chen Y, Leonardson AS, Wang K, Lamb JR, Emilsson V, Schadt EE. Characterizing dynamic changes in the human blood transcriptional network. Plos Computational Biology. 6: e1000671. PMID 20168994 DOI: 10.1371/Journal.Pcbi.1000671  0.342
2010 Su W, Sieberts SK, Kleinhanz RR, Lux K, Millstein J, Molony C, Schadt EE. Assessing the prospects of genome-wide association studies performed in inbred mice. Mammalian Genome. 21: 143-152. PMID 20135320 DOI: 10.1007/S00335-010-9249-7  0.389
2010 Fraser HB, Moses AM, Schadt EE. Evidence for widespread adaptive evolution of gene expression in budding yeast. Proceedings of the National Academy of Sciences of the United States of America. 107: 2977-82. PMID 20133628 DOI: 10.1073/Pnas.0912245107  0.371
2010 Zhang W, Zhu J, Schadt EE, Liu JS. A Bayesian partition method for detecting pleiotropic and epistatic eQTL modules. Plos Computational Biology. 6: e1000642. PMID 20090830 DOI: 10.1371/Journal.Pcbi.1000642  0.373
2010 Hao K, Chudin E, Greenawalt D, Schadt EE. Magnitude of stratification in human populations and impacts on genome wide association studies. Plos One. 5: e8695. PMID 20084173 DOI: 10.1371/Journal.Pone.0008695  0.363
2010 Fraser HB, Schadt EE. The quantitative genetics of phenotypic robustness. Plos One. 5: e8635. PMID 20072615 DOI: 10.1371/Journal.Pone.0008635  0.357
2010 Leonardson AS, Zhu J, Chen Y, Wang K, Lamb JR, Reitman M, Emilsson V, Schadt EE. The effect of food intake on gene expression in human peripheral blood. Human Molecular Genetics. 19: 159-69. PMID 19837700 DOI: 10.1093/Hmg/Ddp476  0.359
2010 Schadt E. Abstract 2011: Separating the signal from the noise: DNA variation as a perturbagen distinguishes between causal and follower genes associated with tumorigenesis and progression in a heptacellular carcinoma (HCC) cohort Cancer Research. 70: 2011-2011. DOI: 10.1158/1538-7445.Am10-2011  0.395
2010 Cotsapas C, Speliotes EK, Hatoum IJ, Greenawalt DM, Dobrin R, Lum PY, Suver C, Chudin E, Kemp D, Reitman M, Voight BF, Neale BM, Schadt EE, Hirschhorn JN, Kaplan LM, et al. Corrigendum to Common body mass index-associated variants confer risk of extreme obesity [Human Molecular Genetics, 2009; 18;18, 3502-3507, 10.1093/hmg/ddp292] Human Molecular Genetics. 19: 3690-3691. DOI: 10.1093/Hmg/Ddq287  0.302
2010 Fraser HB, Moses AM, Schadt EE. Reply to Jensen and Rando: Population size change does not account for widespread gene expression adaptation in yeast Proceedings of the National Academy of Sciences of the United States of America. 107: E111. DOI: 10.1073/Pnas.1006152107  0.336
2009 Wang K, Narayanan M, Zhong H, Tompa M, Schadt EE, Zhu J. Meta-analysis of inter-species liver co-expression networks elucidates traits associated with common human diseases. Plos Computational Biology. 5: e1000616. PMID 20019805 DOI: 10.1371/Journal.Pcbi.1000616  0.368
2009 Argmann C, Dobrin R, Heikkinen S, Auburtin A, Pouilly L, Cock TA, Koutnikova H, Zhu J, Schadt EE, Auwerx J. Ppargamma2 is a key driver of longevity in the mouse. Plos Genetics. 5: e1000752. PMID 19997628 DOI: 10.1371/Journal.Pgen.1000752  0.372
2009 Hägg S, Skogsberg J, Lundström J, Noori P, Nilsson R, Zhong H, Maleki S, Shang MM, Brinne B, Bradshaw M, Bajic VB, Samnegård A, Silveira A, Kaplan LM, Gigante B, ... ... Schadt EE, et al. Multi-organ expression profiling uncovers a gene module in coronary artery disease involving transendothelial migration of leukocytes and LIM domain binding 2: the Stockholm Atherosclerosis Gene Expression (STAGE) study. Plos Genetics. 5: e1000754. PMID 19997623 DOI: 10.1371/Journal.Pgen.1000754  0.309
2009 Prokunina-Olsson L, Kaplan LM, Schadt EE, Collins FS. Alternative splicing of TCF7L2 gene in omental and subcutaneous adipose tissue and risk of type 2 diabetes. Plos One. 4: e7231. PMID 19789636 DOI: 10.1371/Journal.Pone.0007231  0.323
2009 Schadt EE. Molecular networks as sensors and drivers of common human diseases Nature. 461: 218-223. PMID 19741703 DOI: 10.1038/Nature08454  0.308
2009 Cotsapas C, Speliotes EK, Hatoum IJ, Greenawalt DM, Dobrin R, Lum PY, Suver C, Chudin E, Kemp D, Reitman M, Voight BF, Neale BM, Schadt EE, Hirschhorn JN, Kaplan LM, et al. Common body mass index-associated variants confer risk of extreme obesity. Human Molecular Genetics. 18: 3502-7. PMID 19553259 DOI: 10.1093/Hmg/Ddp292  0.344
2009 Hao K, Chudin E, McElwee J, Schadt EE. Accuracy of genome-wide imputation of untyped markers and impacts on statistical power for association studies. Bmc Genetics. 10: 27. PMID 19531258 DOI: 10.1186/1471-2156-10-27  0.335
2009 Millstein J, Zhang B, Zhu J, Schadt EE. Disentangling molecular relationships with a causal inference test Bmc Genetics. 10. PMID 19473544 DOI: 10.1186/1471-2156-10-23  0.334
2009 Dobrin R, Zhu J, Molony C, Argman C, Parrish ML, Carlson S, Allan MF, Pomp D, Schadt EE. Multi-tissue coexpression networks reveal unexpected subnetworks associated with disease. Genome Biology. 10: R55. PMID 19463160 DOI: 10.1186/Gb-2009-10-5-R55  0.334
2009 Schadt EE, Zhang B, Zhu J. Advances in systems biology are enhancing our understanding of disease and moving us closer to novel disease treatments Genetica. 136: 259-269. PMID 19363597 DOI: 10.1007/S10709-009-9359-X  0.354
2009 Schadt EE, Friend SH, Shaywitz DA. A network view of disease and compound screening Nature Reviews Drug Discovery. 8: 286-295. PMID 19337271 DOI: 10.1038/Nrd2826  0.3
2009 Scheinfeldt LB, Biswas S, Madeoy J, Connelly CF, Schadt EE, Akey JM. Population genomic analysis of ALMS1 in humans reveals a surprisingly complex evolutionary history. Molecular Biology and Evolution. 26: 1357-67. PMID 19279085 DOI: 10.1093/Molbev/Msp045  0.329
2009 Yang X, Deignan JL, Qi H, Zhu J, Qian S, Zhong J, Torosyan G, Majid S, Falkard B, Kleinhanz RR, Karlsson J, Castellani LW, Mumick S, Wang K, Xie T, ... ... Schadt EE, et al. Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks. Nature Genetics. 41: 415-23. PMID 19270708 DOI: 10.1038/Ng.325  0.381
2009 Tu Z, Argmann C, Wong KK, Mitnaul LJ, Edwards S, Sach IC, Zhu J, Schadt EE. Integrating siRNA and protein-protein interaction data to identify an expanded insulin signaling network. Genome Research. 19: 1057-67. PMID 19261841 DOI: 10.1101/Gr.087890.108  0.301
2009 Vansteelandt S, Goetgeluk S, Lutz S, Waldman I, Lyon H, Schadt EE, Weiss ST, Lange C. On the adjustment for covariates in genetic association analysis: a novel, simple principle to infer direct causal effects. Genetic Epidemiology. 33: 394-405. PMID 19219893 DOI: 10.1002/Gepi.20393  0.361
2009 Lum PY, Derry JMJ, Schadt EE. Integrative genomics and drug development Pharmacogenomics. 10: 203-212. PMID 19207021 DOI: 10.2217/14622416.10.2.203  0.31
2009 Loboda A, Kraft WK, Fine B, Joseph J, Nebozhyn M, Zhang C, He Y, Yang X, Wright C, Morris M, Chalikonda I, Ferguson M, Emilsson V, Leonardson A, Lamb J, ... ... Schadt E, et al. Diurnal variation of the human adipose transcriptome and the link to metabolic disease. Bmc Medical Genomics. 2: 7. PMID 19203388 DOI: 10.1186/1755-8794-2-7  0.324
2009 Heikkinen S, Argmann C, Feige JN, Koutnikova H, Champy M, Dali-Youcef N, Schadt EE, Laakso M, Auwerx J. The Pro12Ala PPARγ2 Variant Determines Metabolism at the Gene-Environment Interface Cell Metabolism. 9: 88-98. PMID 19117549 DOI: 10.1016/J.Cmet.2008.11.007  0.304
2009 Kathiresan S, Willer CJ, Peloso GM, Demissie S, Musunuru K, Schadt EE, Kaplan L, Bennett D, Li Y, Tanaka T, Voight BF, Bonnycastle LL, Jackson AU, Crawford G, Surti A, et al. Common variants at 30 loci contribute to polygenic dyslipidemia. Nature Genetics. 41: 56-65. PMID 19060906 DOI: 10.1038/Ng.291  0.494
2009 van Nas A, Guhathakurta D, Wang SS, Yehya N, Horvath S, Zhang B, Ingram-Drake L, Chaudhuri G, Schadt EE, Drake TA, Arnold AP, Lusis AJ. Elucidating the role of gonadal hormones in sexually dimorphic gene coexpression networks. Endocrinology. 150: 1235-49. PMID 18974276 DOI: 10.1210/En.2008-0563  0.342
2009 Farber CR, van Nas A, Ghazalpour A, Aten JE, Doss S, Sos B, Schadt EE, Ingram-Drake L, Davis RC, Horvath S, Smith DJ, Drake TA, Lusis AJ. An integrative genetics approach to identify candidate genes regulating BMD: combining linkage, gene expression, and association. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 24: 105-16. PMID 18767929 DOI: 10.1359/Jbmr.080908  0.788
2009 Cervino AC, Li G, Edwards S, Zhu J, Laurie C, Tokiwa G, Lum PY, Wang S, Castellani LW, Lusis AJ, Carlson S, Sachs AB, Schadt EE. Corrigendum to "Integrating QTL and high-density SNP analyses in mice to identify Insig2 as a susceptibility gene for plasma cholesterol levels" [Genomics 86 (2005) 505-517] (DOI:10.1016/j.ygeno.2005.07.010) Genomics. 93: 399. DOI: 10.1016/J.Ygeno.2008.12.005  0.327
2008 Keating BJ, Tischfield S, Murray SS, Bhangale T, Price TS, Glessner JT, Galver L, Barrett JC, Grant SF, Farlow DN, Chandrupatla HR, Hansen M, Ajmal S, Papanicolaou GJ, Guo Y, ... ... Schadt E, et al. Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. Plos One. 3: e3583. PMID 18974833 DOI: 10.1371/Journal.Pone.0003583  0.58
2008 Degnan JH, Lasky-Su J, Raby BA, Xu M, Molony C, Schadt EE, Lange C. Genomics and genome-wide association studies: an integrative approach to expression QTL mapping. Genomics. 92: 129-33. PMID 18586451 DOI: 10.1016/J.Ygeno.2008.05.012  0.382
2008 Hao K, Schadt EE, Storey JD. Calibrating the performance of SNP arrays for whole-genome association studies. Plos Genetics. 4: e1000109. PMID 18584036 DOI: 10.1371/Journal.Pgen.1000109  0.339
2008 Zhu J, Zhang B, Smith EN, Drees B, Brem RB, Kruglyak L, Bumgarner RE, Schadt EE. Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks. Nature Genetics. 40: 854-61. PMID 18552845 DOI: 10.1038/Ng.167  0.322
2008 Schadt EE, Molony C, Chudin E, Hao K, Yang X, Lum PY, Kasarskis A, Zhang B, Wang S, Suver C, Zhu J, Millstein J, Sieberts S, Lamb J, GuhaThakurta D, et al. Mapping the genetic architecture of gene expression in human liver. Plos Biology. 6: e107. PMID 18462017 DOI: 10.1371/Journal.Pbio.0060107  0.443
2008 Lasky-Su J, Lyon HN, Emilsson V, Heid IM, Molony C, Raby BA, Lazarus R, Klanderman B, Soto-Quiros ME, Avila L, Silverman EK, Thorleifsson G, Thorsteinsdottir U, Kronenberg F, Vollmert C, ... ... Schadt E, et al. On the replication of genetic associations: timing can be everything! American Journal of Human Genetics. 82: 849-58. PMID 18387595 DOI: 10.1016/J.Ajhg.2008.01.018  0.328
2008 Zhu J, Zhang B, Schadt EE. A systems biology approach to drug discovery. Advances in Genetics. 60: 603-635. PMID 18358334 DOI: 10.1016/S0065-2660(07)00421-X  0.4
2008 Chen Y, Zhu J, Lum PY, Yang X, Pinto S, MacNeil DJ, Zhang C, Lamb J, Edwards S, Sieberts SK, Leonardson A, Castellini LW, Wang S, Champy MF, Zhang B, ... ... Schadt EE, et al. Variations in DNA elucidate molecular networks that cause disease. Nature. 452: 429-35. PMID 18344982 DOI: 10.1038/Nature06757  0.41
2008 Emilsson V, Thorleifsson G, Zhang B, Leonardson AS, Zink F, Zhu J, Carlson S, Helgason A, Walters GB, Gunnarsdottir S, Mouy M, Steinthorsdottir V, Eiriksdottir GH, Bjornsdottir G, Reynisdottir I, ... ... Schadt EE, et al. Genetics of gene expression and its effect on disease. Nature. 452: 423-8. PMID 18344981 DOI: 10.1038/Nature06758  0.414
2008 Schadt EE. Reconstructing The Circuits Of Disease:From Molecular States To Physiological States Genome Informatics. 21: 231-231. DOI: 10.11234/Gi1990.21.231  0.337
2007 Fan X, Zhu J, Schadt EE, Liu JS. Statistical power of phylo-HMM for evolutionarily conserved element detection. Bmc Bioinformatics. 8: 374. PMID 17919331 DOI: 10.1186/1471-2105-8-374  0.303
2007 Laurie CC, Nickerson DA, Anderson AD, Weir BS, Livingston RJ, Dean MD, Smith KL, Schadt EE, Nachman MW. Linkage disequilibrium in wild mice. Plos Genetics. 3: e144. PMID 17722986 DOI: 10.1371/Journal.Pgen.0030144  0.358
2007 Sieberts SK, Schadt EE. Moving toward a system genetics view of disease Mammalian Genome. 18: 389-401. PMID 17653589 DOI: 10.1007/S00335-007-9040-6  0.408
2007 Wang SS, Schadt EE, Wang H, Wang X, Ingram-Drake L, Shi W, Drake TA, Lusis AJ. Identification of pathways for atherosclerosis in mice: integration of quantitative trait locus analysis and global gene expression data. Circulation Research. 101: e11-30. PMID 17641228 DOI: 10.1161/Circresaha.107.152975  0.385
2007 Zhu J, Wiener MC, Zhang C, Fridman A, Minch E, Lum PY, Sachs JR, Schadt EE. Increasing the power to detect causal associations by combining genotypic and expression data in segregating populations. Plos Computational Biology. 3: e69. PMID 17432931 DOI: 10.1371/Journal.Pcbi.0030069  0.354
2007 Meng H, Vera I, Che N, Wang X, Wang SS, Ingram-Drake L, Schadt EE, Drake TA, Lusis AJ. Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics. Proceedings of the National Academy of Sciences of the United States of America. 104: 4530-5. PMID 17360558 DOI: 10.1073/Pnas.0607620104  0.403
2007 Itoh Y, Melamed E, Yang X, Kampf K, Wang S, Yehya N, Van Nas A, Replogle K, Band MR, Clayton DF, Schadt EE, Lusis AJ, Arnold AP. Dosage compensation is less effective in birds than in mammals. Journal of Biology. 6: 2. PMID 17352797 DOI: 10.1186/Jbiol53  0.304
2007 Hovatta I, Zapala MA, Broide RS, Schadt EE, Libiger O, Schork NJ, Lockhart DJ, Barlow C. DNA variation and brain region-specific expression profiles exhibit different relationships between inbred mouse strains: implications for eQTL mapping studies. Genome Biology. 8: R25. PMID 17324278 DOI: 10.1186/Gb-2007-8-2-R25  0.31
2007 Grupe A, Abraham R, Li Y, Rowland C, Hollingworth P, Morgan A, Jehu L, Segurado R, Stone D, Schadt E, Karnoub M, Nowotny P, Tacey K, Catanese J, Sninsky J, et al. Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants. Human Molecular Genetics. 16: 865-73. PMID 17317784 DOI: 10.1093/Hmg/Ddm031  0.363
2006 Schadt EE, Lum PY. Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Reverse engineering gene networks to identify key drivers of complex disease phenotypes. Journal of Lipid Research. 47: 2601-2613. PMID 17012750 DOI: 10.1194/Jlr.R600026-Jlr200  0.401
2006 GuhaThakurta D, Xie T, Anand M, Edwards SW, Li G, Wang SS, Schadt EE. Cis-regulatory variations: a study of SNPs around genes showing cis-linkage in segregating mouse populations. Bmc Genomics. 7: 235. PMID 16978413 DOI: 10.1186/1471-2164-7-235  0.362
2006 Ghazalpour A, Doss S, Zhang B, Wang S, Plaisier C, Castellanos R, Brozell A, Schadt EE, Drake TA, Lusis AJ, Horvath S. Integrating genetic and network analysis to characterize genes related to mouse weight. Plos Genetics. 2: e130. PMID 16934000 DOI: 10.1371/Journal.Pgen.0020130  0.401
2006 Schadt EE. Novel integrative genomics strategies to identify genes for complex traits Animal Genetics. 37: 18-23. PMID 16886998 DOI: 10.1111/J.1365-2052.2006.01473.X  0.406
2006 Yang X, Schadt EE, Wang S, Wang H, Arnold AP, Ingram-Drake L, Drake TA, Lusis AJ. Tissue-specific expression and regulation of sexually dimorphic genes in mice. Genome Research. 16: 995-1004. PMID 16825664 DOI: 10.1101/Gr.5217506  0.335
2006 Drake TA, Schadt EE, Lusis AJ. Integrating genetic and gene expression data: Application to cardiovascular and metabolic traits in mice Mammalian Genome. 17: 466-479. PMID 16783628 DOI: 10.1007/S00335-005-0175-Z  0.423
2006 Lum PY, Chen Y, Zhu J, Lamb J, Melmed S, Wang S, Drake TA, Lusis AJ, Schadt EE. Elucidating the murine brain transcriptional network in a segregating mouse population to identify core functional modules for obesity and diabetes. Journal of Neurochemistry. 97: 50-62. PMID 16635250 DOI: 10.1111/J.1471-4159.2006.03661.X  0.408
2006 Wang S, Yehya N, Schadt EE, Wang H, Drake TA, Lusis AJ. Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity Plos Genetics. 2. PMID 16462940 DOI: 10.1371/Journal.Pgen.0020015  0.384
2006 Grupe A, Li Y, Rowland C, Abraham R, Hollingworth P, Morgan A, Jehu L, Stone D, Schadt E, Karnoub M, Nowotny P, Tacey K, Catanese J, Sninsky J, Rubinsztein D, et al. O2-02-05: Novel candidate genes for late-onset Alzheimer's disease from a large scale association study of 20K functional variants Alzheimer's & Dementia. 2: S33-S33. DOI: 10.1016/J.Jalz.2006.05.115  0.309
2005 Drake TA, Schadt EE, Davis RC, Lusis AJ. Integrating genetic and gene expression data to study the metabolic syndrome and diabetes in mice. American Journal of Therapeutics. 12: 503-11. PMID 16280644 DOI: 10.1097/01.Mjt.0000178775.39149.64  0.36
2005 Schadt EE. Exploiting naturally occurring DNA variation and molecular profiling data to dissect disease and drug response traits. Current Opinion in Biotechnology. 16: 647-654. PMID 16249078 DOI: 10.1016/J.Copbio.2005.10.005  0.398
2005 Mehrabian M, Allayee H, Stockton J, Lum PY, Drake TA, Castellani LW, Suh M, Armour C, Edwards S, Lamb J, Lusis AJ, Schadt EE. Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits. Nature Genetics. 37: 1224-33. PMID 16200066 DOI: 10.1038/Ng1619  0.408
2005 Cervino AC, Li G, Edwards S, Zhu J, Laurie C, Tokiwa G, Lum PY, Wang S, Castellani LW, Castellini LW, Lusis AJ, Carlson S, Sachs AB, Schadt EE. Integrating QTL and high-density SNP analyses in mice to identify Insig2 as a susceptibility gene for plasma cholesterol levels. Genomics. 86: 505-17. PMID 16126366 DOI: 10.1016/J.Ygeno.2005.07.010  0.347
2005 Schadt EE, Sachs A, Friend S. Embracing complexity, inching closer to reality. Science's Stke : Signal Transduction Knowledge Environment. 2005: pe40. PMID 16077086 DOI: 10.1126/Stke.2952005Pe40  0.302
2005 Ghazalpour A, Doss S, Sheth SS, Ingram-Drake LA, Schadt EE, Lusis AJ, Drake TA. Genomic analysis of metabolic pathway gene expression in mice. Genome Biology. 6: R59. PMID 15998448 DOI: 10.1186/Gb-2005-6-7-R59  0.361
2005 Schadt EE, Lamb J, Yang X, Zhu J, Edwards S, Guhathakurta D, Sieberts SK, Monks S, Reitman M, Zhang C, Lum PY, Leonardson A, Thieringer R, Metzger JM, Yang L, et al. An integrative genomics approach to infer causal associations between gene expression and disease. Nature Genetics. 37: 710-7. PMID 15965475 DOI: 10.1038/Ng1589  0.407
2005 Doss S, Schadt EE, Drake TA, Lusis AJ. Cis-acting expression quantitative trait loci in mice. Genome Research. 15: 681-91. PMID 15837804 DOI: 10.1101/Gr.3216905  0.348
2005 Davis RC, Schadt EE, Cervino AC, Péterfy M, Lusis AJ. Ultrafine mapping of SNPs from mouse strains C57BL/6J, DBA/2J, and C57BLKS/J for loci contributing to diabetes and atherosclerosis susceptibility. Diabetes. 54: 1191-9. PMID 15793261 DOI: 10.2337/Diabetes.54.4.1191  0.308
2005 Johnson JM, Edwards S, Shoemaker D, Schadt EE. Dark matter in the genome: evidence of widespread transcription detected by microarray tiling experiments. Trends in Genetics. 21: 93-102. PMID 15661355 DOI: 10.1016/J.Tig.2004.12.009  0.338
2005 Zhu J, Wiener MC, Zhang C, Fridman A, Minch E, Lum PY, Sachs JR, Schadt EE. Increasing the Power to Detect Causal Associations among Genes and between Genes and Complex Traits by Combining Genotypic and Gene Expression Data in Segregating Populations Plos Computational Biology. DOI: 10.1371/Journal.Pcbi.0030069.Eor  0.36
2004 Monks SA, Leonardson A, Zhu H, Cundiff P, Pietrusiak P, Edwards S, Phillips JW, Sachs A, Schadt EE. Genetic inheritance of gene expression in human cell lines. American Journal of Human Genetics. 75: 1094-105. PMID 15514893 DOI: 10.1086/426461  0.396
2004 Churchill GA, Airey DC, Allayee H, Angel JM, Attie AD, Beatty J, Beavis WD, Belknap JK, Bennett B, Berrettini W, Bleich A, Bogue M, Broman KW, Buck KJ, Buckler E, ... ... Schadt EE, et al. The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nature Genetics. 36: 1133-7. PMID 15514660 DOI: 10.1038/Ng1104-1133  0.351
2004 Schadt EE, Edwards SW, GuhaThakurta D, Holder D, Ying L, Svetnik V, Leonardson A, Hart KW, Russell A, Li G, Cavet G, Castle J, McDonagh P, Kan Z, Chen R, et al. A comprehensive transcript index of the human genome generated using microarrays and computational approaches. Genome Biology. 5: R73. PMID 15461792 DOI: 10.1186/Gb-2004-5-10-R73  0.326
2004 Zhu J, Lum PY, Lamb J, GuhaThakurta D, Edwards SW, Thieringer R, Berger JP, Wu MS, Thompson J, Sachs AB, Schadt EE. An integrative genomics approach to the reconstruction of gene networks in segregating populations. Cytogenetic and Genome Research. 105: 363-74. PMID 15237224 DOI: 10.1159/000078209  0.328
2003 Johnson JM, Castle J, Garrett-Engele P, Kan Z, Loerch PM, Armour CD, Santos R, Schadt EE, Stoughton R, Shoemaker DD. Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays. Science (New York, N.Y.). 302: 2141-4. PMID 14684825 DOI: 10.1126/Science.1090100  0.34
2003 He YD, Dai H, Schadt EE, Cavet G, Edwards SW, Stepaniants SB, Duenwald S, Kleinhanz R, Jones AR, Shoemaker DD, Stoughton RB. Microarray standard data set and figures of merit for comparing data processing methods and experiment designs. Bioinformatics. 19: 956-965. PMID 12761058 DOI: 10.1093/Bioinformatics/Btg126  0.313
2003 Kraft P, Schadt E, Aten J, Horvath S. A family-based test for correlation between gene expression and trait values. American Journal of Human Genetics. 72: 1323-30. PMID 12687497 DOI: 10.1086/375167  0.77
2003 Schadt EE, Monks SA, Friend SH. A new paradigm for drug discovery: integrating clinical, genetic, genomic and molecular phenotype data to identify drug targets. Biochemical Society Transactions. 31: 437-443. PMID 12653656 DOI: 10.1042/Bst0310437  0.403
2003 Schadt EE, Monks SA, Drake TA, Lusis AJ, Che N, Colinayo V, Ruff TG, Milligan SB, Lamb JR, Cavet G, Linsley PS, Mao M, Stoughton RB, Friend SH. Genetics of gene expression surveyed in maize, mouse and man Nature. 422: 297-302. PMID 12646919 DOI: 10.1038/Nature01434  0.408
2002 Schadt EE, Sinsheimer JS, Lange K. Applications of codon and rate variation models in molecular phylogeny. Molecular Biology and Evolution. 19: 1550-62. PMID 12200482 DOI: 10.1093/Oxfordjournals.Molbev.A004217  0.523
2002 Schadt E, Lange K. Codon and Rate Variation Models in Molecular Phylogeny Molecular Biology and Evolution. 19: 1534-1549. PMID 12200481 DOI: 10.1093/Oxfordjournals.Molbev.A004216  0.504
2001 Waring JF, Jolly RA, Ciurlionis R, Lum PY, Praestgaard JT, Morfitt DC, Buratto B, Roberts C, Schadt E, Ulrich RG. Clustering of hepatotoxins based on mechanism of toxicity using gene expression profiles. Toxicology and Applied Pharmacology. 175: 28-42. PMID 11509024 DOI: 10.1006/Taap.2001.9243  0.337
2001 Shoemaker DD, Schadt EE, Armour CD, He YD, Garrett-Engele P, McDonagh PD, Loerch PM, Leonardson A, Lum PY, Cavet G, Wu LF, Altschuler SJ, Edwards S, King J, Tsang JS, et al. Experimental annotation of the human genome using microarray technology. Nature. 409: 922-7. PMID 11237012 DOI: 10.1038/35057141  0.367
2001 Schadt EE, Li C, Su C, Wong WH. Analyzing high-density oligonucleotide gene expression array data. Journal of Cellular Biochemistry. 80: 192-202. PMID 11074587 DOI: 10.1002/1097-4644(20010201)80:2<192::Aid-Jcb50>3.0.Co;2-W  0.327
2000 Ewart SL, Kuperman D, Schadt E, Tankersley C, Grupe A, Shubitowski DM, Peltz G, Wills-Karp M. Quantitative trait loci controlling allergen-induced airway hyperresponsiveness in inbred mice American Journal of Respiratory Cell and Molecular Biology. 23: 537-545. PMID 11017920 DOI: 10.1165/Ajrcmb.23.4.4199  0.31
1998 Schadt EE, Sinsheimer JS, Lange K. Computational advances in maximum likelihood methods for molecular phylogeny Genome Research. 8: 222-233. PMID 9521926 DOI: 10.1101/Gr.8.3.222  0.504
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