Eric E. Schadt, Ph.D. - Publications

Affiliations: 
University of California, Los Angeles, Los Angeles, CA 

450 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Landi I, Kaji DA, Cotter L, Van Vleck T, Belbin G, Preuss M, Loos RJF, Kenny E, Glicksberg BS, Beckmann ND, O'Reilly P, Schadt EE, Achtyes ED, Buckley PF, Lehrer D, et al. Prognostic value of polygenic risk scores for adults with psychosis. Nature Medicine. PMID 34489608 DOI: 10.1038/s41591-021-01475-7  1
2021 Argmann C, Tokuyama M, Ungaro RC, Huang R, Hou R, Gurunathan S, Kosoy R, Di'Narzo A, Wang W, Losic B, Irizar H, Peters L, Stojmirovic A, Wei G, Comella PH, ... ... Schadt EE, et al. Molecular characterization of limited ulcerative colitis reveals novel biology and predictors of disease extension. Gastroenterology. PMID 34480882 DOI: 10.1053/j.gastro.2021.08.053  1
2021 Li S, Sarangarajan R, Jun T, Kao YH, Wang Z, Hao K, Schadt E, Kiebish MA, Granger E, Narain NR, Chen R, Schadt EE, Li L. Association of in-hospital use of ACE-I/ARB and COVID-19 outcomes in African American population. The Journal of Clinical Investigation. PMID 34411004 DOI: 10.1172/JCI151418  1
2021 Beckmann ND, Comella PH, Cheng E, Lepow L, Beckmann AG, Tyler SR, Mouskas K, Simons NW, Hoffman GE, Francoeur NJ, Del Valle DM, Kang G, Do A, Moya E, Wilkins L, ... ... Schadt EE, et al. Downregulation of exhausted cytotoxic T cells in gene expression networks of multisystem inflammatory syndrome in children. Nature Communications. 12: 4854. PMID 34381049 DOI: 10.1038/s41467-021-24981-1  1
2021 Voloudakis G, Hoffman G, Venkatesh S, Lee KM, Dobrindt K, Vicari JM, Zhang W, Beckmann ND, Jiang S, Hoagland D, Bian J, Gao L, Corvelo A, Cho K, Lee JS, ... ... Schadt EE, et al. IL10RB as a key regulator of COVID-19 host susceptibility and severity. Medrxiv : the Preprint Server For Health Sciences. PMID 34100031 DOI: 10.1101/2021.05.31.21254851  1
2021 Feng Z, Clemente JC, Wong B, Schadt EE. Detecting and phasing minor single-nucleotide variants from long-read sequencing data. Nature Communications. 12: 3032. PMID 34031367 DOI: 10.1038/s41467-021-23289-4  1
2021 Ayers KL, Ma M, Debussche G, Corrigan D, McCafferty J, Lee K, Newman S, Zhou X, Hirsch FR, Mack PC, Liu JJ, Schadt EE, Chen R, Li SD. A composite biomarker of neutrophil-lymphocyte ratio and hemoglobin level correlates with clinical response to PD-1 and PD-L1 inhibitors in advanced non-small cell lung cancers. Bmc Cancer. 21: 441. PMID 33882890 DOI: 10.1186/s12885-021-08194-9  1
2021 Wang L, Sfakianos JP, Beaumont KG, Akturk G, Horowitz A, Sebra RP, Farkas AM, Gnjatic S, Hake A, Izadmehr S, Wiklund P, Oh WK, Szabo PM, Wind-Rotolo M, Unsal-Kacmaz K, ... ... Schadt E, et al. Myeloid Cell-associated Resistance to PD-1/PD-L1 Blockade in Urothelial Cancer Revealed Through Bulk and Single-cell RNA Sequencing. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 33837006 DOI: 10.1158/1078-0432.CCR-20-4574  1
2021 Ayers KL, Mullaney T, Zhou X, Liu JJ, Lee K, Ma M, Jones S, Li L, Redfern A, Jappe W, Liu Z, Goldsweig H, Yadav KK, Hahner N, Dietz M, ... ... Schadt EE, et al. Analysis of real-world data to investigate the impact of race and ethnicity on response to PD-1 and PD-L1 inhibitors in advanced non-small cell lung cancers. The Oncologist. PMID 33829580 DOI: 10.1002/onco.13780  1
2021 Kosoy R, Kim-Schulze S, Rahman A, Friedman JR, Huang R, Peters LA, Amir EA, Perrigoue J, Stojmirovic A, Song WM, Hao K, Ungaro R, Mehandru S, Cho J, Dubinsky M, ... ... Schadt EE, et al. Deep analysis of the peripheral immune system in IBD reveals new insight in disease subtyping and response to mono or combination therapies. Cellular and Molecular Gastroenterology and Hepatology. PMID 33813036 DOI: 10.1016/j.jcmgh.2021.03.012  1
2021 Nguyen-Dumont T, Dowty JG, MacInnis RJ, Steen JA, Riaz M, Dugué PA, Renault AL, Hammet F, Mahmoodi M, Theys D, Tsimiklis H, Severi G, Bolton D, Lacaze P, Sebra R, ... Schadt E, et al. Rare Germline Pathogenic Variants Identified by Multigene Panel Testing and the Risk of Aggressive Prostate Cancer. Cancers. 13. PMID 33804961 DOI: 10.3390/cancers13071495  1
2021 Webb BD, Evans A, Naidich TP, Bird L, Parikh S, Garcia MF, Henderson LB, Millan F, Si Y, Brennand KJ, Hung P, Rucker JC, Wheeler PG, Schadt EE. Haploinsufficiency of POU4F1 causes an ataxia syndrome with hypotonia and intention tremor. Human Mutation. PMID 33783914 DOI: 10.1002/humu.24201  1
2021 Bangi E, Smibert P, Uzilov AV, Teague AG, Gopinath S, Antipin Y, Chen R, Hecht C, Gruszczynski N, Yon WJ, Malyshev D, Laspina D, Selkridge I, Wang H, Gomez J, ... ... Schadt EE, et al. A Drosophila platform identifies a novel, personalized therapy for a patient with adenoid cystic carcinoma. Iscience. 24: 102212. PMID 33733072 DOI: 10.1016/j.isci.2021.102212  1
2021 Graff M, Justice AE, Young KL, Marouli E, Zhang X, Fine RS, Lim E, Buchanan V, Rand K, Feitosa MF, Wojczynski MK, Yanek LR, Shao Y, Rohde R, Adeyemo AA, ... ... Schadt E, et al. Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry. American Journal of Human Genetics. PMID 33713608 DOI: 10.1016/j.ajhg.2021.02.011  1
2021 Di Narzo AF, Hart A, Kosoy R, Peters L, Stojmirovic A, Cheng H, Zhang Z, Shan M, Cho J, Kasarskis A, Argmann C, Peter I, Schadt EE, Hao K. Polygenic Risk Score for Alcohol Drinking Behavior Improves Prediction of Inflammatory Bowel Disease Risk. Human Molecular Genetics. PMID 33601420 DOI: 10.1093/hmg/ddab045  1
2021 Comella PH, Gonzalez-Kozlova E, Kosoy R, Charney AW, Peradejordi IF, Chandrasekar S, Tyler SR, Wang W, Losic B, Zhu J, Hoffman GE, Kim-Schulze S, Qi J, Patel M, Kasarskis A, ... ... Schadt EE, et al. A Molecular network approach reveals shared cellular and molecular signatures between chronic fatigue syndrome and other fatiguing illnesses. Medrxiv : the Preprint Server For Health Sciences. PMID 33564792 DOI: 10.1101/2021.01.29.21250755  1
2021 Charney AW, Simons NW, Mouskas K, Lepow L, Cheng E, Le Berichel J, Chang C, Marvin R, Del Valle DM, Calorossi S, Lansky A, Walker L, Patel M, Xie H, Yi N, ... ... Schadt EE, et al. Author Correction: Sampling the host response to SARS-CoV-2 in hospitals under siege. Nature Medicine. PMID 33547460 DOI: 10.1038/s41591-021-01247-3  1
2021 Neff RA, Wang M, Vatansever S, Guo L, Ming C, Wang Q, Wang E, Horgusluoglu-Moloch E, Song WM, Li A, Castranio EL, Tcw J, Ho L, Goate A, Fossati V, ... ... Schadt E, et al. Molecular subtyping of Alzheimer's disease using RNA sequencing data reveals novel mechanisms and targets. Science Advances. 7. PMID 33523961 DOI: 10.1126/sciadv.abb5398  1
2021 Cohain AT, Barrington WT, Jordan DM, Beckmann ND, Argmann CA, Houten SM, Charney AW, Ermel R, Sukhavasi K, Franzen O, Koplev S, Whatling C, Belbin GM, Yang J, Hao K, ... ... Schadt EE, et al. An integrative multiomic network model links lipid metabolism to glucose regulation in coronary artery disease. Nature Communications. 12: 547. PMID 33483510 DOI: 10.1038/s41467-020-20750-8  1
2020 Carcamo-Orive I, Henrion MYR, Zhu K, Beckmann ND, Cundiff P, Moein S, Zhang Z, Alamprese M, D'Souza SL, Wabitsch M, Schadt EE, Quertermous T, Knowles JW, Chang R. Predictive network modeling in human induced pluripotent stem cells identifies key driver genes for insulin responsiveness. Plos Computational Biology. 16: e1008491. PMID 33362275 DOI: 10.1371/journal.pcbi.1008491  1
2020 Petralia F, Tignor N, Reva B, Koptyra M, Chowdhury S, Rykunov D, Krek A, Ma W, Zhu Y, Ji J, Calinawan A, Whiteaker JR, Colaprico A, Stathias V, Omelchenko T, ... ... Schadt EE, et al. Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer. Cell. PMID 33242424 DOI: 10.1016/j.cell.2020.10.044  1
2020 Kahali B, Chen Y, Feitosa MF, Bielak LF, O'Connell JR, Musani SK, Hegde Y, Chen Y, Stetson LC, Guo X, Fu YP, Smith AV, Ryan KA, Eiriksdottir G, Cohain AT, ... ... Schadt EE, et al. A noncoding variant near PPP1R3B promotes liver glycogen storage and MetS, but protects against myocardial infarction. The Journal of Clinical Endocrinology and Metabolism. PMID 33231259 DOI: 10.1210/clinem/dgaa855  1
2020 Sun M, Shankar R, Ko M, Chang CD, Yeh SJ, Li S, Liu K, Zhou G, Xing J, VanVelsen A, VanVelsen T, Paithankar S, Feng BY, Young K, Strug M, ... ... Schadt E, et al. Sex differences in viral entry protein expression, host responses to SARS-CoV-2, and in vitro responses to sex steroid hormone treatment in COVID-19. Research Square. PMID 33173861 DOI: 10.21203/rs.3.rs-100914/v1  1
2020 Wang Z, Zheutlin A, Kao YH, Ayers K, Gross S, Kovatch P, Nirenberg S, Charney A, Nadkarni G, De Freitas JK, O'Reilly P, Just A, Horowitz C, Martin G, Branch A, ... ... Schadt E, et al. Hospitalised COVID-19 patients of the Mount Sinai Health System: a retrospective observational study using the electronic medical records. Bmj Open. 10: e040441. PMID 33109676 DOI: 10.1136/bmjopen-2020-040441  1
2020 Karakose E, Wang H, Inabnet W, Thakker RV, Libutti S, Fernandez-Ranvier G, Suh H, Stevenson M, Kinoshita Y, Donovan M, Antipin Y, Li Y, Liu X, Jin F, Wang P, ... ... Schadt EE, et al. Aberrant methylation underlies insulin gene expression in human insulinoma. Nature Communications. 11: 5210. PMID 33060578 DOI: 10.1038/s41467-020-18839-1  1
2020 Vaid A, Somani S, Russak AJ, De Freitas JK, Chaudhry FF, Paranjpe I, Johnson KW, Lee SJ, Miotto R, Richter F, Zhao S, Beckmann ND, Naik N, Kia A, Timsina P, ... ... Schadt EE, et al. Machine Learning to Predict Mortality and Critical Events in COVID-19 Positive New York City Patients: A Cohort Study. Journal of Medical Internet Research. PMID 33027032 DOI: 10.2196/24018  1
2020 Suárez-Fariñas M, Tokuyama M, Wei G, Huang R, Livanos A, Jha D, Levescot A, Irizar H, Kosoy R, Cording S, Wang W, Losic B, Ungaro R, Di'Narzo A, Martinez-Delgado G, ... ... Schadt EE, et al. Intestinal inflammation modulates the expression of ACE2 and TMPRSS2 and potentially overlaps with the pathogenesis of SARS-CoV-2 related disease. Gastroenterology. PMID 32980345 DOI: 10.1053/j.gastro.2020.09.029  1
2020 Anderson WD, Soh JY, Innis SE, Dimanche A, Ma L, Langefeld CD, Comeau ME, Das SK, Schadt EE, Björkegren JLM, Civelek M. Sex differences in human adipose tissue gene expression and genetic regulation involve adipogenesis. Genome Research. PMID 32967914 DOI: 10.1101/gr.264614.120  1
2020 Beckmann ND, Comella PH, Cheng E, Lepow L, Beckmann AG, Mouskas K, Simons NW, Hoffman GE, Francoeur NJ, Del Valle DM, Kang G, Moya E, Wilkins L, Le Berichel J, Chang C, ... ... Schadt EE, et al. Cytotoxic lymphocytes are dysregulated in multisystem inflammatory syndrome in children. Medrxiv : the Preprint Server For Health Sciences. PMID 32909006 DOI: 10.1101/2020.08.29.20182899  1
2020 Chan L, Chaudhary K, Saha A, Chauhan K, Vaid A, Zhao S, Paranjpe I, Somani S, Richter F, Miotto R, Lala A, Kia A, Timsina P, Li L, Freeman R, ... ... Schadt E, et al. AKI in Hospitalized Patients with COVID-19. Journal of the American Society of Nephrology : Jasn. PMID 32883700 DOI: 10.1681/Asn.2020050615  1
2020 Del Valle DM, Kim-Schulze S, Huang HH, Beckmann ND, Nirenberg S, Wang B, Lavin Y, Swartz TH, Madduri D, Stock A, Marron TU, Xie H, Patel M, Tuballes K, Van Oekelen O, ... ... Schadt E, et al. An inflammatory cytokine signature predicts COVID-19 severity and survival. Nature Medicine. PMID 32839624 DOI: 10.1038/S41591-020-1051-9  1
2020 Do AN, Chun Y, Grishina G, Grishin A, Rogers AJ, Raby BA, Weiss ST, Vicencio A, Schadt EE, Bunyavanich S. Network study of nasal transcriptome profiles reveals master regulator genes of asthma. The Journal of Allergy and Clinical Immunology. PMID 32828590 DOI: 10.1016/J.Jaci.2020.07.006  1
2020 Charney AW, Simons NW, Mouskas K, Lepow L, Cheng E, Le Berichel J, Chang C, Marvin R, Del Valle DM, Calorossi S, Lansky A, Walker L, Patel M, Xie H, Yi N, ... ... Schadt EE, et al. Author Correction: Sampling the host response to SARS-CoV-2 in hospitals under siege. Nature Medicine. PMID 32826990 DOI: 10.1038/S41591-020-1057-3  1
2020 Beckmann ND, Lin WJ, Wang M, Cohain AT, Charney AW, Wang P, Ma W, Wang YC, Jiang C, Audrain M, Comella PH, Fakira AK, Hariharan SP, Belbin GM, Girdhar K, ... ... Schadt EE, et al. Multiscale causal networks identify VGF as a key regulator of Alzheimer's disease. Nature Communications. 11: 3942. PMID 32770063 DOI: 10.1038/S41467-020-17405-Z  1
2020 Charney AW, Simons NW, Mouskas K, Lepow L, Cheng E, Le Berichel J, Chang C, Marvin R, Del Valle DM, Calorossi S, Lansky A, Walker L, Patel M, Xie H, Yi N, ... ... Schadt EE, et al. Sampling the host response to SARS-CoV-2 in hospitals under siege. Nature Medicine. PMID 32719485 DOI: 10.1038/S41591-020-1004-3  1
2020 Wan YW, Al-Ouran R, Mangleburg CG, Perumal TM, Lee TV, Allison K, Swarup V, Funk CC, Gaiteri C, Allen M, Wang M, Neuner SM, Kaczorowski CC, Philip VM, Howell GR, ... ... Schadt E, et al. Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models. Cell Reports. 32: 107908. PMID 32668255 DOI: 10.1016/J.Celrep.2020.107908  1
2020 Lacaze P, Sebra R, Riaz M, Tiller J, Revote J, Phung J, Parker EJ, Orchard SG, Lockery JE, Wolfe R, Strahl M, Wang YC, Chen R, Sisco D, Arnold T, ... ... Schadt E, et al. Medically actionable pathogenic variants in a population of 13,131 healthy elderly individuals. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 32606442 DOI: 10.1038/S41436-020-0881-7  1
2020 Richter F, Morton SU, Kim SW, Kitaygorodsky A, Wasson LK, Chen KM, Zhou J, Qi H, Patel N, DePalma SR, Parfenov M, Homsy J, Gorham JM, Manheimer KB, Velinder M, ... ... Schadt EE, et al. Genomic analyses implicate noncoding de novo variants in congenital heart disease. Nature Genetics. PMID 32601476 DOI: 10.1038/S41588-020-0652-Z  1
2020 Lacaze P, Sebra R, Riaz M, Hooper AJ, Tiller J, Bakshi A, Woods RL, Tonkin AM, Reid CM, Murray AM, Nicholls SJ, Watts GF, Schadt E, McNeil JJ. Familial Hypercholesterolemia in a Healthy Elderly Population. Circulation. Genomic and Precision Medicine. PMID 32522009 DOI: 10.1161/CIRCGEN.120.002938  1
2020 Del Valle DM, Kim-Schulze S, Hsin-Hui H, Beckmann ND, Nirenberg S, Wang B, Lavin Y, Swartz T, Madduri D, Stock A, Marron T, Xie H, Patel MK, van Oekelen O, Rahman A, ... ... Schadt E, et al. An inflammatory cytokine signature helps predict COVID-19 severity and death. Medrxiv : the Preprint Server For Health Sciences. PMID 32511562 DOI: 10.1101/2020.05.28.20115758  1
2020 Johnson ECB, Dammer EB, Duong DM, Ping L, Zhou M, Yin L, Higginbotham LA, Guajardo A, White B, Troncoso JC, Thambisetty M, Montine TJ, Lee EB, Trojanowski JQ, Beach TG, ... ... Schadt E, et al. Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation. Nature Medicine. PMID 32284590 DOI: 10.1038/S41591-020-0815-6  1
2020 Chun Y, Do A, Grishina G, Grishin A, Fang G, Rose S, Spencer C, Vicencio A, Schadt E, Bunyavanich S. Integrative study of the upper and lower airway microbiome and transcriptome in asthma. Jci Insight. 5. PMID 32161195 DOI: 10.1172/Jci.Insight.133707  1
2020 Wang L, Sebra RP, Sfakianos JP, Allette K, Wang W, Yoo S, Bhardwaj N, Schadt EE, Yao X, Galsky MD, Zhu J. A reference profile-free deconvolution method to infer cancer cell-intrinsic subtypes and tumor-type-specific stromal profiles. Genome Medicine. 12: 24. PMID 32111252 DOI: 10.1186/S13073-020-0720-0  1
2020 Horgusluoglu-Moloch E, Xiao G, Wang M, Wang Q, Zhou X, Nho K, Saykin AJ, Schadt E, Zhang B. Systems modeling of white matter microstructural abnormalities in Alzheimer's disease. Neuroimage. Clinical. 26: 102203. PMID 32062565 DOI: 10.1016/J.Nicl.2020.102203  1
2020 Woo YJ, Roussos P, Haroutunian V, Katsel P, Gandy S, Schadt EE, Zhu J. Comparison of brain connectomes by MRI and genomics and its implication in Alzheimer's disease. Bmc Medicine. 18: 23. PMID 32024511 DOI: 10.1186/S12916-019-1488-1  1
2020 Hadas Y, Vincek AS, Youssef E, Żak MM, Chepurko E, Sultana N, Sharkar MTK, Guo N, Komargodski R, Kurian AA, Kaur K, Magadum A, Fargnoli A, Katz MG, Hossain N, ... ... Schadt E, et al. Altering Sphingolipid Metabolism Attenuates Cell Death and Inflammatory Response after Myocardial Infarction. Circulation. PMID 31992066 DOI: 10.1161/Circulationaha.119.041882  0.01
2020 Losic B, Craig AJ, Villacorta-Martin C, Martins-Filho SN, Akers N, Chen X, Ahsen ME, von Felden J, Labgaa I, DʹAvola D, Allette K, Lira SA, Furtado GC, Garcia-Lezana T, Restrepo P, ... ... Schadt EE, et al. Intratumoral heterogeneity and clonal evolution in liver cancer. Nature Communications. 11: 291. PMID 31941899 DOI: 10.1038/S41467-019-14050-Z  1
2020 Voskoboinik I, Lacaze P, Jang HS, Flinsenberg T, Fernando SL, Kerridge I, Riaz M, Sebra R, Thia K, Noori T, Schadt EE, McNeil JJ, Trapani JA. Prevalence and disease predisposition of p.A91V perforin in an aged Caucasian population. Blood. PMID 31932842 DOI: 10.1182/Blood.2019003487  1
2020 El Gaamouch F, Audrain M, Lin WJ, Beckmann N, Jiang C, Hariharan S, Heeger PS, Schadt EE, Gandy S, Ehrlich ME, Salton SR. VGF-derived peptide TLQP-21 modulates microglial function through C3aR1 signaling pathways and reduces neuropathology in 5xFAD mice. Molecular Neurodegeneration. 15: 4. PMID 31924226 DOI: 10.1186/S13024-020-0357-X  1
2020 Liu Y, Wang L, Yu H, Parekh SS, Schadt E, Zhu J. ISS stage and network risk score to predict benefits of multiple myeloma treatment options. Journal of Clinical Oncology. 38. DOI: 10.1200/Jco.2020.38.15_Suppl.E20511  1
2020 Gopinath S, Cagan R, Schadt E. Abstract B17: Modeling genomic complexity of colorectal cancer using multigenic Drosophila models Cancer Research. 80. DOI: 10.1158/1538-7445.Camodels2020-B17  0.01
2020 Petralia F, Tignor N, Reva B, Raman P, Chowdhury S, Rykunov D, Krek A, Ma W, Ji J, Song X, Zhu Y, Rokita JL, Colaprico A, Calinawan A, Whiteaker JR, ... ... Schadt EE, et al. Abstract 445: Integrated proteogenomic characterization across seven histological types of pediatric brain tumors Cancer Research. 80: 445-445. DOI: 10.1158/1538-7445.Am2020-445  1
2019 Akler G, Birch AH, Schreiber-Agus N, Cai X, Cai G, Shi L, Yu C, Larmore AM, Mendiratta-Vij G, Elkhoury L, Dillon MW, Zhu J, Mclellan AS, Suer FE, Webb BD, ... Schadt EE, et al. Lessons learned from expanded reproductive carrier screening in self-reported Ashkenazi, Sephardi, and Mizrahi Jewish patients. Molecular Genetics & Genomic Medicine. e1053. PMID 31880409 DOI: 10.1002/mgg3.1053  1
2019 Etheridge AS, Gallins PJ, Jima D, Broadaway KA, Ratain MJ, Schuetz E, Schadt E, Schroder A, Molony C, Zhou Y, Mohlke KL, Wright FA, Innocenti F. A new liver eQTL map from 1,183 individuals provides evidence for novel eQTLs of drug response, metabolic and sex-biased phenotypes. Clinical Pharmacology and Therapeutics. PMID 31868224 DOI: 10.1002/Cpt.1751  1
2019 Do AN, Watson CT, Cohain AT, Griffin RS, Grishin A, Wood RA, Burks WA, Jones SM, Scurlock A, Leung DYM, Sampson HA, Sicherer SH, Sharp AJ, Schadt EE, Bunyavanich S. Dual transcriptomic and epigenomic study of reaction severity in peanut allergic children. The Journal of Allergy and Clinical Immunology. PMID 31838046 DOI: 10.1016/J.Jaci.2019.10.040  1
2019 Ouahed J, Spencer E, Kotlarz D, Shouval DS, Kowalik M, Peng K, Field M, Grushkin-Lerner L, Pai SY, Bousvaros A, Cho J, Argmann C, Schadt E, Mcgovern DPB, Mokry M, et al. Very Early Onset Inflammatory Bowel Disease: A Clinical Approach With a Focus on the Role of Genetics and Underlying Immune Deficiencies. Inflammatory Bowel Diseases. PMID 31833544 DOI: 10.1093/Ibd/Izz259  1
2019 Oliveira PH, Ribis JW, Garrett EM, Trzilova D, Kim A, Sekulovic O, Mead EA, Pak T, Zhu S, Deikus G, Touchon M, Lewis-Sandari M, Beckford C, Zeitouni NE, Altman DR, ... ... Schadt EE, et al. Epigenomic characterization of Clostridioides difficile finds a conserved DNA methyltransferase that mediates sporulation and pathogenesis. Nature Microbiology. PMID 31768029 DOI: 10.1038/S41564-019-0613-4  1
2019 Glicksberg BS, Amadori L, Akers NK, Sukhavasi K, Franzén O, Li L, Belbin GM, Ayers KL, Shameer K, Badgeley MA, Johnson KW, Readhead B, Darrow BJ, Kenny EE, Betsholtz C, ... ... Schadt EE, et al. Correction to: Integrative analysis of loss-of-function variants in clinical and genomic data reveals novel genes associated with cardiovascular traits. Bmc Medical Genomics. 12: 154. PMID 31684948 DOI: 10.1186/s12920-019-0573-9  1
2019 Clark DJ, Dhanasekaran SM, Petralia F, Pan J, Song X, Hu Y, da Veiga Leprevost F, Reva B, Lih TM, Chang HY, Ma W, Huang C, Ricketts CJ, Chen L, Krek A, ... ... Schadt E, et al. Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma. Cell. 179: 964-983.e31. PMID 31675502 DOI: 10.1016/J.Cell.2019.10.007  1
2019 Yang J, Peng S, Zhang B, Houten S, Schadt E, Zhu J, Suh Y, Tu Z. Human geroprotector discovery by targeting the converging subnetworks of aging and age-related diseases. Geroscience. PMID 31637571 DOI: 10.1007/s11357-019-00106-x  1
2019 Sullivan MJ, Altman DR, Chacko KI, Ciferri B, Webster E, Pak TR, Deikus G, Lewis-Sandari M, Khan Z, Beckford C, Rendo A, Samaroo F, Sebra R, Karam-Howlin R, Dingle T, ... ... Schadt E, et al. A complete genome screening program of clinical methicillin-resistant isolates identifies the origin and progression of a neonatal intensive care unit outbreak. Journal of Clinical Microbiology. PMID 31578260 DOI: 10.1128/Jcm.01261-19  1
2019 Liu Y, Yu H, Yoo S, Lee E, Laganà A, Parekh S, Schadt EE, Wang L, Zhu J. A Network Analysis of Multiple Myeloma Related Gene Signatures. Cancers. 11. PMID 31569720 DOI: 10.3390/Cancers11101452  1
2019 Hoffman GE, Bendl J, Girdhar K, Schadt EE, Roussos P. Functional interpretation of genetic variants using deep learning predicts impact on chromatin accessibility and histone modification. Nucleic Acids Research. PMID 31544924 DOI: 10.1093/Nar/Gkz808  1
2019 Fang G, Wang W, Paunic V, Heydari H, Costanzo M, Liu X, Liu X, VanderSluis B, Oately B, Steinbach M, Van Ness B, Schadt EE, Pankratz ND, Boone C, Kumar V, et al. Discovering genetic interactions bridging pathways in genome-wide association studies. Nature Communications. 10: 4274. PMID 31537791 DOI: 10.1038/S41467-019-12131-7  1
2019 Martin JC, Chang C, Boschetti G, Ungaro R, Giri M, Grout JA, Gettler K, Chuang LS, Nayar S, Greenstein AJ, Dubinsky M, Walker L, Leader A, Fine JS, Whitehurst CE, ... ... Schadt EE, et al. Single-Cell Analysis of Crohn's Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy. Cell. PMID 31474370 DOI: 10.1016/J.Cell.2019.08.008  1
2019 Zhang W, Voloudakis G, Rajagopal VM, Readhead B, Dudley JT, Schadt EE, Björkegren JLM, Kim Y, Fullard JF, Hoffman GE, Roussos P. Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traits. Nature Communications. 10: 3834. PMID 31444360 DOI: 10.1038/S41467-019-11874-7  1
2019 Glicksberg BS, Amadori L, Akers NK, Sukhavasi K, Franzén O, Li L, Belbin GM, Akers KL, Shameer K, Badgeley MA, Johnson KW, Readhead B, Darrow BJ, Kenny EE, Betsholtz C, ... ... Schadt EE, et al. Integrative analysis of loss-of-function variants in clinical and genomic data reveals novel genes associated with cardiovascular traits. Bmc Medical Genomics. 12: 108. PMID 31345219 DOI: 10.1186/S12920-019-0542-3  1
2019 Botton MR, Lu X, Zhao G, Repnikova E, Seki Y, Gaedigk A, Schadt EE, Edelmann L, Scott SA. Structural variation at the CYP2C locus: Characterization of deletion and duplication alleles. Human Mutation. PMID 31260137 DOI: 10.1002/humu.23855  1
2019 Zeng L, Talukdar HA, Koplev S, Giannarelli C, Ivert T, Gan LM, Ruusalepp A, Schadt EE, Kovacic JC, Lusis AJ, Michoel T, Schunkert H, Björkegren JLM. Contribution of Gene Regulatory Networks to Heritability of Coronary Artery Disease. Journal of the American College of Cardiology. 73: 2946-2957. PMID 31196451 DOI: 10.1016/J.Jacc.2019.03.520  1
2019 Kronman H, Richter F, Labonté B, Chandra R, Zhao S, Hoffman G, Lobo MK, Schadt EE, Nestler EJ. Biology and Bias in Cell Type-Specific RNAseq of Nucleus Accumbens Medium Spiny Neurons. Scientific Reports. 9: 8350. PMID 31171808 DOI: 10.1038/S41598-019-44798-9  1
2019 Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK, van der Laan SW, Gretarsdottir S, Anderson CD, Chong M, Adams HHH, Ago T, Almgren P, ... ... Schadt EE, et al. Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nature Genetics. PMID 31160810 DOI: 10.1038/S41588-019-0449-0  1
2019 Bangi E, Ang C, Smibert P, Uzilov AV, Teague AG, Antipin Y, Chen R, Hecht C, Gruszczynski N, Yon WJ, Malyshev D, Laspina D, Selkridge I, Rainey H, Moe AS, ... ... Schadt EE, et al. A personalized platform identifies trametinib plus zoledronate for a patient with KRAS-mutant metastatic colorectal cancer. Science Advances. 5: eaav6528. PMID 31131321 DOI: 10.1126/Sciadv.Aav6528  1
2019 Kojima Y, Downing K, Kundu R, Miller C, Dewey F, Lancero H, Raaz U, Perisic L, Hedin U, Schadt E, Maegdefessel L, Quertermous T, Leeper NJ. Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis. The Journal of Clinical Investigation. 129: 2164. PMID 31042164 DOI: 10.1172/JCI129277  1
2019 Richter F, Hoffman GE, Manheimer KB, Patel N, Sharp AJ, McKean D, Morton SU, DePalma S, Gorham J, Kitaygorodksy A, Porter GA, Giardini A, Shen Y, Chung WK, Seidman JG, ... ... Schadt EE, et al. ORE Identifies Extreme Expression Effects Enriched for Rare Variants. Bioinformatics (Oxford, England). PMID 30903145 DOI: 10.1093/Bioinformatics/Btz202  1
2019 Zoltick ES, Linderman MD, McGinniss MA, Ramos E, Ball MP, Church GM, Leonard DGB, Pereira S, McGuire AL, Caskey CT, Sanderson SC, Schadt EE, Nielsen DE, Crawford SD, Green RC, et al. Predispositional genome sequencing in healthy adults: design, participant characteristics, and early outcomes of the PeopleSeq Consortium. Genome Medicine. 11: 10. PMID 30808425 DOI: 10.1186/S13073-019-0619-9  1
2019 Contijoch EJ, Britton GJ, Yang C, Mogno I, Li Z, Ng R, Llewellyn SR, Hira S, Johnson C, Rabinowitz KM, Barkan R, Dotan I, Hirten RP, Fu SC, Luo Y, ... ... Schadt EE, et al. Gut microbiota density influences host physiology and is shaped by host and microbial factors. Elife. 8. PMID 30666957 DOI: 10.7554/Elife.40553  1
2019 Ma M, Zhou X, Goldsweig H, Hahner N, Han D, Dietz M, Jones S, Mullaney T, Redfern A, Jappe W, Liu Z, Yadav K, Zimmerman M, Prentice T, Pan Q, ... ... Schadt EE, et al. Analysis of real-world data (RWD) on treatment (tx) sequencing in patients with advanced non-small cell lung cancer (aNSCLC). Journal of Clinical Oncology. 37. DOI: 10.1200/Jco.2019.37.15_Suppl.E20642  1
2019 Liu Z, Ma M, Grover K, Li L, Goldsweig H, Yadav K, Zhou X, Mullaney T, Redfern A, Jappe W, Zimmerman M, Prentice T, Pan Q, Oh WK, Schadt EE, et al. Investigating racial differences in treatment responses through analysis of real-world data (RWD). Journal of Clinical Oncology. 37. DOI: 10.1200/Jco.2019.37.15_Suppl.E18141  1
2019 McCafferty J, Grover K, Li L, Li Z, Fink MY, Goldsweig H, Ma M, Zhou X, Mullaney T, Redfern A, Jappe W, Zimmerman M, Prentice T, Pan Q, Oh WK, ... Schadt E, et al. A systematic analysis of off-label drug use in real-world data (RWD) across more than 145,000 cancer patients. Journal of Clinical Oncology. 37. DOI: 10.1200/Jco.2019.37.15_Suppl.E18031  1
2019 Blazquez A, Rubinsteyn A, Kodysh J, Finnigan JP, Marron TU, Meseck M, O'Donnell T, Hammerbacher J, Donovan MJ, Mahajan M, Miles BA, Irie H, Tiersten A, Tewari A, Parekh SS, ... ... Schadt EE, et al. A phase I study of the safety and immunogenicity of a multi-peptide personalized genomic vaccine in the adjuvant treatment of solid tumors and hematological malignancies. Journal of Clinical Oncology. 37. DOI: 10.1200/Jco.2019.37.15_Suppl.E14307  1
2019 Blazquez AB, Rubinsteyn A, Kodysh J, Finnigan JP, Marron T, Sabado RL, Meseck M, O'Donnell TJ, Hammerbacher J, Donovan M, Holt J, Mahajan M, Mandeli J, Misiukiewicz K, Genden EM, ... ... Schadt EE, et al. Abstract A005: A phase I study of the safety and immunogenicity of a multipeptide personalized genomic vaccine in the adjuvant treatment of solid cancers Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-A005  1
2019 Briton-Jones C, Sekhon L, Ellis E, Lee JA, Schadt EE, Sebra RP, Copperman AB. Characterizing meiotic and mitotic errors in the inner cell mass and trophectoderm of poor quality preimplantation embryos Fertility and Sterility. 112. DOI: 10.1016/J.Fertnstert.2019.07.1383  1
2019 Liharska L, Park YJ, Sonar S, Feng C, Huckins L, Sklar P, Schadt E, Kopell B, Beckmann N, Charney A. S58Imputing The Molecular State Of The Human Prefrontal Cortex From Peripheral Blood Samples European Neuropsychopharmacology. 29. DOI: 10.1016/J.Euroneuro.2019.08.059  1
2019 Sonar S, Liharska L, Park Y, Feng C, Schadt E, Stahl E, Beckmann N, Charney A. S56Estimating The Heritability Of Gene Expression In The Human Prefrontal And Temporal Cortices European Neuropsychopharmacology. 29. DOI: 10.1016/J.Euroneuro.2019.08.057  1
2019 Zhang W, Voloudakis G, Rajagopal V, Schadt E, Björkegren J, Fullard J, Hoffman G, Roussos P. 237. Large-Scale Gene-Trait Association Study Identifies Novel Genes Across Multiple Traits Biological Psychiatry. 85. DOI: 10.1016/J.Biopsych.2019.03.251  1
2018 Genes N, Violante S, Cetrangol C, Rogers L, Schadt EE, Chan YY. From smartphone to EHR: a case report on integrating patient-generated health data. Npj Digital Medicine. 1: 23. PMID 31304305 DOI: 10.1038/s41746-018-0030-8  1
2018 Kajiwara Y, Wang E, Wang M, Sin WC, Brennand KJ, Schadt E, Naus CC, Buxbaum J, Zhang B. GJA1 (connexin43) is a key regulator of Alzheimer's disease pathogenesis. Acta Neuropathologica Communications. 6: 144. PMID 30577786 DOI: 10.1186/S40478-018-0642-X  1
2018 Beaulaurier J, Schadt EE, Fang G. Deciphering bacterial epigenomes using modern sequencing technologies. Nature Reviews. Genetics. PMID 30546107 DOI: 10.1038/S41576-018-0081-3  1
2018 Franceschini N, Giambartolomei C, de Vries PS, Finan C, Bis JC, Huntley RP, Lovering RC, Tajuddin SM, Winkler TW, Graff M, Kavousi M, Dale C, Smith AV, Hofer E, van Leeuwen EM, ... ... Schadt EE, et al. GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes. Nature Communications. 9: 5141. PMID 30510157 DOI: 10.1038/S41467-018-07340-5  1
2018 Haure-Mirande JV, Wang M, Audrain M, Fanutza T, Kim SH, Heja S, Readhead B, Dudley JT, Blitzer RD, Schadt EE, Zhang B, Gandy S, Ehrlich ME. Correction: Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden. Molecular Psychiatry. PMID 30464330 DOI: 10.1038/S41380-018-0301-4  1
2018 Readhead B, Hartley BJ, Eastwood BJ, Collier DA, Evans D, Farias R, He C, Hoffman G, Sklar P, Dudley JT, Schadt EE, Savić R, Brennand KJ. Author Correction: Expression-based drug screening of neural progenitor cells from individuals with schizophrenia. Nature Communications. 9: 4926. PMID 30451900 DOI: 10.1038/S41467-018-07326-3  1
2018 Di Narzo AF, Brodmerkel C, Telesco SE, Argmann C, Peters LA, Li K, Kidd B, Dudley J, Cho J, Schadt EE, Kasarskis A, Dobrin R, Hao K. High Throughput Identification of Plasma Proteomic Signature of Inflammatory Bowel Disease. Journal of Crohn's & Colitis. PMID 30445421 DOI: 10.1093/Ecco-Jcc/Jjy190  1
2018 Nanda V, Wang T, Pjanic M, Liu B, Nguyen T, Matic LP, Hedin U, Koplev S, Ma L, Franzén O, Ruusalepp A, Schadt EE, Björkegren JLM, Montgomery SB, Snyder MP, et al. Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus. Plos Genetics. 14: e1007755. PMID 30444878 DOI: 10.1371/Journal.Pgen.1007755  1
2018 Devchand PR, Liu T, Altman RB, FitzGerald GA, Schadt EE. The Pioglitazone Trek via Human PPAR Gamma: From Discovery to a Medicine at the FDA and Beyond. Frontiers in Pharmacology. 9: 1093. PMID 30337873 DOI: 10.3389/Fphar.2018.01093  0.01
2018 Huang F, Wang M, Liu R, Wang JZ, Schadt E, Haroutunian V, Katsel P, Zhang B, Wang X. CDT2-controlled cell cycle reentry regulates the pathogenesis of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 30321504 DOI: 10.1016/J.Jalz.2018.08.013  1
2018 Martignetti JA, Pandya D, Nagarsheth N, Chen Y, Camacho O, Tomita S, Brodman M, Ascher-Walsh C, Kolev V, Cohen S, Harkins T, Schadt E, Reva B, Sebra R, Dottino P. Detection of endometrial precancer by a targeted gynecologic cancer liquid biopsy. Cold Spring Harbor Molecular Case Studies. PMID 30301868 DOI: 10.1101/mcs.a003269  1
2018 Raj T, Li YI, Wong G, Humphrey J, Wang M, Ramdhani S, Wang YC, Ng B, Gupta I, Haroutunian V, Schadt EE, Young-Pearse T, Mostafavi S, Zhang B, Sklar P, et al. Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer's disease susceptibility. Nature Genetics. PMID 30297968 DOI: 10.1038/S41588-018-0238-1  1
2018 Haure-Mirande JV, Wang M, Audrain M, Fanutza T, Kim SH, Heja S, Readhead B, Dudley JT, Blitzer RD, Schadt EE, Zhang B, Gandy S, Ehrlich ME. Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden. Molecular Psychiatry. PMID 30283032 DOI: 10.1038/S41380-018-0255-6  1
2018 Audrain M, Haure-Mirande JV, Wang M, Kim SH, Fanutza T, Chakrabarty P, Fraser P, St George-Hyslop PH, Golde TE, Blitzer RD, Schadt EE, Zhang B, Ehrlich ME, Gandy S. Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau. Molecular Psychiatry. PMID 30283031 DOI: 10.1038/S41380-018-0258-3  1
2018 Lin L, Chen Q, Hirsch JP, Yoo S, Yeung K, Bumgarner RE, Tu Z, Schadt EE, Zhu J. Temporal genetic association and temporal genetic causality methods for dissecting complex networks. Nature Communications. 9: 3980. PMID 30266904 DOI: 10.1038/S41467-018-06203-3  1
2018 Wang M, Beckmann ND, Roussos P, Wang E, Zhou X, Wang Q, Ming C, Neff R, Ma W, Fullard JF, Hauberg ME, Bendl J, Peters MA, Logsdon B, Wang P, ... ... Schadt E, et al. The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease. Scientific Data. 5: 180185. PMID 30204156 DOI: 10.1038/Sdata.2018.185  1
2018 Petyuk VA, Chang R, Ramirez-Restrepo M, Beckmann ND, Henrion MYR, Piehowski PD, Zhu K, Wang S, Clarke J, Huentelman MJ, Xie F, Andreev V, Engel A, Guettoche T, Navarro L, ... ... Schadt E, et al. The human brainome: network analysis identifies HSPA2 as a novel Alzheimer's disease target. Brain : a Journal of Neurology. PMID 30137212 DOI: 10.1093/Brain/Awy215  1
2018 Altman DR, Sullivan MJ, Chacko KI, Balasubramanian D, Pak TR, Sause WE, Kumar K, Sebra R, Deikus G, Attie O, Rose H, Lewis M, Fulmer Y, Bashir A, Kasarskis A, ... Schadt EE, et al. Genome plasticity of -defective during clinical infection. Infection and Immunity. PMID 30061376 DOI: 10.1128/Iai.00331-18  1
2018 Wong SY, Coffre M, Ramanan D, Hines MJ, Gomez LE, Peters LA, Schadt EE, Koralov SB, Cadwell K. B Cell Defects Observed in Knockout Mice Are a Consequence of a Mutation Frequently Found in Inbred Strains. Journal of Immunology (Baltimore, Md. : 1950). PMID 30012848 DOI: 10.4049/Jimmunol.1800014  1
2018 Moreno CL, Guardia LD, Shnyder V, Ortiz-Virumbrales M, Kruglikov I, Zhang B, Schadt EE, Tanzi RE, Noggle S, Buettner C, Gandy S. iPSC-derived familial Alzheimer's PSEN2 cholinergic neurons exhibit mutation-dependent molecular pathology corrected by insulin signaling. Molecular Neurodegeneration. 13: 33. PMID 29945658 DOI: 10.1186/S13024-018-0265-5  1
2018 Readhead B, Haure-Mirande JV, Funk CC, Richards MA, Shannon P, Haroutunian V, Sano M, Liang WS, Beckmann ND, Price ND, Reiman EM, Schadt EE, Ehrlich ME, Gandy S, Dudley JT. Multiscale Analysis of Independent Alzheimer's Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus. Neuron. PMID 29937276 DOI: 10.1016/J.Neuron.2018.05.023  1
2018 Pandey G, Pandey OP, Rogers AJ, Ahsen ME, Hoffman GE, Raby BA, Weiss ST, Schadt EE, Bunyavanich S. A Nasal Brush-based Classifier of Asthma Identified by Machine Learning Analysis of Nasal RNA Sequence Data. Scientific Reports. 8: 8826. PMID 29891868 DOI: 10.1038/S41598-018-27189-4  1
2018 Chan YY, Bot BM, Zweig M, Tignor N, Ma W, Suver C, Cedeno R, Scott ER, Gregory Hershman S, Schadt EE, Wang P. The asthma mobile health study, smartphone data collected using ResearchKit. Scientific Data. 5: 180096. PMID 29786695 DOI: 10.1038/Sdata.2018.96  1
2018 Zhu S, Beaulaurier J, Deikus G, Wu T, Strahl M, Hao Z, Luo G, Gregory JA, Chess A, He C, Xiao A, Sebra R, Schadt EE, Fang G. Mapping and characterizing N6-methyladenine in eukaryotic genomes using single molecule real-time sequencing. Genome Research. PMID 29764913 DOI: 10.1101/Gr.231068.117  1
2018 Hauberg ME, Fullard JF, Zhu L, Cohain AT, Giambartolomei C, Misir R, Reach S, Johnson JS, Wang M, Mattheisen M, Børglum AD, Zhang B, Sieberts SK, Peters MA, Domenici E, ... Schadt EE, et al. Differential activity of transcribed enhancers in the prefrontal cortex of 537 cases with schizophrenia and controls. Molecular Psychiatry. PMID 29740122 DOI: 10.1038/S41380-018-0059-8  1
2018 Ayers KL, Glicksberg BS, Garfield AS, Longerich S, White JA, Yang P, Du L, Chittenden TW, Gulcher JR, Roy S, Fiedorek F, Gottesdiener K, Cohen S, North KE, Schadt EE, et al. Melanocortin-4 receptor pathway dysfunction in obesity: Patient stratification aimed at MC4R agonist treatment. The Journal of Clinical Endocrinology and Metabolism. PMID 29726959 DOI: 10.1210/Jc.2018-00258  1
2018 Lake NJ, Webb BD, Stroud DA, Richman TR, Ruzzenente B, Compton AG, Mountford HS, Pulman J, Zangarelli C, Rio M, Boddaert N, Assouline Z, Sherpa MD, Schadt EE, Houten SM, et al. Biallelic Mutations in MRPS34 Lead to Instability of the Small Mitoribosomal Subunit and Leigh Syndrome. American Journal of Human Genetics. 102: 713. PMID 29625026 DOI: 10.1016/J.Ajhg.2018.03.015  1
2018 Sekiya M, Wang M, Fujisaki N, Sakakibara Y, Quan X, Ehrlich ME, De Jager PL, Bennett DA, Schadt EE, Gandy S, Ando K, Zhang B, Iijima KM. Integrated biology approach reveals molecular and pathological interactions among Alzheimer's Aβ42, Tau, TREM2, and TYROBP in Drosophila models. Genome Medicine. 10: 26. PMID 29598827 DOI: 10.1186/S13073-018-0530-9  1
2018 Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK, van der Laan SW, Gretarsdottir S, Anderson CD, Chong M, Adams HHH, Ago T, Almgren P, ... ... Schadt EE, et al. Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nature Genetics. PMID 29531354 DOI: 10.1038/s41588-018-0058-3  1
2018 Franzén O, Ermel R, Sukhavasi K, Jain R, Jain A, Betsholtz C, Giannarelli C, Kovacic JC, Ruusalepp A, Skogsberg J, Hao K, Schadt EE, Björkegren JLM. Global analysis of A-to-I RNA editing reveals association with common disease variants. Peerj. 6: e4466. PMID 29527417 DOI: 10.7717/Peerj.4466  1
2018 Akers NK, Schadt EE, Losic B. STAR Chimeric Post For Rapid Detection of Circular RNA and Fusion Transcripts. Bioinformatics (Oxford, England). PMID 29474638 DOI: 10.1093/bioinformatics/bty091  1
2018 Linderman MD, Sanderson SC, Bashir A, Diaz GA, Kasarskis A, Zinberg R, Mahajan M, Suckiel SA, Zweig M, Schadt EE. Impacts of incorporating personal genome sequencing into graduate genomics education: a longitudinal study over three course years. Bmc Medical Genomics. 11: 5. PMID 29382336 DOI: 10.1186/S12920-018-0319-0  1
2018 Hui KY, Fernandez-Hernandez H, Hu J, Schaffner A, Pankratz N, Hsu NY, Chuang LS, Carmi S, Villaverde N, Li X, Rivas M, Levine AP, Bao X, Labrias PR, Haritunians T, ... ... Schadt EE, et al. Functional variants in the LRRK2 gene confer shared effects on risk for Crohn's disease and Parkinson's disease. Science Translational Medicine. 10. PMID 29321258 DOI: 10.1126/Scitranslmed.Aai7795  1
2018 Contijoch EJ, Britton GJ, Yang C, Mogno I, Li Z, Ng R, Llewellyn SR, Hira S, Johnson C, Rabinowitz KM, Barkan R, Dotan I, Hirten RP, Fu S, Luo Y, ... ... Schadt EE, et al. Author response: Gut microbiota density influences host physiology and is shaped by host and microbial factors Elife. DOI: 10.7554/Elife.40553.033  1
2018 Losic B, Craig AJ, Martins-Filho SN, Villacorta-Martin C, Akers N, Chen X, Ahsen ME, Labgaa I, D'Avola D, Lira SA, Furtado GC, Stueck A, Ward SC, Fiel MI, Gunasekaran G, ... ... Schadt EE, et al. Abstract 1189: Deciphering the impact of immune editing on liver cancer clonal evolution using immunogenomics Tumor Biology. DOI: 10.1158/1538-7445.Am2018-1189  1
2018 Beaumont K, Copperman AB, Dottino P, Martignetti J, Schadt E, Sebra R. Multiparameter Single Cell Characterization of Ovarian Intratumor Heterogeneity [29A] Obstetrics & Gynecology. 131. DOI: 10.1097/01.Aog.0000532892.87767.De  1
2018 Sekhon L, Lee J, Wang Y, Briton-Jones C, Schadt E, Sebra RP, Copperman AB. Normal growth versus early developmental arrest of the human embryo: understanding molecular network perturbations Fertility and Sterility. 110. DOI: 10.1016/J.Fertnstert.2018.07.984  1
2018 Sekhon L, Ellis E, Nazem TG, Wang Y, Lee J, Briton-Jones C, Schadt E, Sebra RP, Copperman AB. Understanding the scope and significance of mosaicism in human preimplantation embryos Fertility and Sterility. 110. DOI: 10.1016/J.Fertnstert.2018.07.418  1
2018 Sekhon L, Allette K, Ellis E, Wang Y, Lee J, Briton-Jones C, Schadt E, Sebra RP, Copperman AB. The morula stage transcriptome is characterized by marked upregulation of genes that mediate key mitochondrial functions Fertility and Sterility. 110. DOI: 10.1016/J.Fertnstert.2018.07.247  1
2017 Yang J, Hagen J, Guntur KV, Allette K, Schuyler S, Ranjan J, Petralia F, Gesta S, Sebra R, Mahajan M, Zhang B, Zhu J, Houten S, Kasarskis A, Vishnudas VK, ... ... Schadt EE, et al. A next generation sequencing based approach to identify extracellular vesicle mediated mRNA transfers between cells. Bmc Genomics. 18: 987. PMID 29273013 DOI: 10.1186/S12864-017-4359-1  1
2017 Galsky MD, Wang H, Hahn NM, Twardowski P, Pal SK, Albany C, Fleming MT, Starodub A, Hauke RJ, Yu M, Zhao Q, Sonpavde G, Donovan MJ, Patel VG, Sfakianos JP, ... ... Schadt EE, et al. Phase 2 Trial of Gemcitabine, Cisplatin, plus Ipilimumab in Patients with Metastatic Urothelial Cancer and Impact of DNA Damage Response Gene Mutations on Outcomes. European Urology. PMID 29248319 DOI: 10.1016/J.Eururo.2017.12.001  1
2017 Beaulaurier J, Zhu S, Deikus G, Mogno I, Zhang XS, Davis-Richardson A, Canepa R, Triplett EW, Faith JJ, Sebra R, Schadt EE, Fang G. Metagenomic binning and association of plasmids with bacterial host genomes using DNA methylation. Nature Biotechnology. PMID 29227468 DOI: 10.1038/Nbt.4037  1
2017 Forst CV, Zhou B, Wang M, Chou TW, Mason G, Song WM, Schadt E, Ghedin E, Zhang B. Integrative gene network analysis identifies key signatures, intrinsic networks and host factors for influenza virus A infections. Npj Systems Biology and Applications. 3: 35. PMID 29214055 DOI: 10.1038/s41540-017-0036-x  1
2017 Watson CT, Cohain AT, Griffin RS, Chun Y, Grishin A, Hacyznska H, Hoffman GE, Beckmann ND, Shah H, Dawson P, Henning A, Wood R, Burks AW, Jones SM, Leung DYM, ... ... Schadt EE, et al. Integrative transcriptomic analysis reveals key drivers of acute peanut allergic reactions. Nature Communications. 8: 1943. PMID 29203772 DOI: 10.1038/S41467-017-02188-7  1
2017 Zillikens MC, Demissie S, Hsu YH, Yerges-Armstrong LM, Chou WC, Stolk L, Livshits G, Broer L, Johnson T, Koller DL, Kutalik Z, Luan J, Malkin I, Ried JS, Smith AV, ... ... Schadt EE, et al. Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. Nature Communications. 8: 1414. PMID 29116125 DOI: 10.1038/s41467-017-01008-2  1
2017 McKenzie AT, Moyon S, Wang M, Katsyv I, Song WM, Zhou X, Dammer EB, Duong DM, Aaker J, Zhao Y, Beckmann N, Wang P, Zhu J, Lah JJ, Seyfried NT, ... ... Schadt EE, et al. Multiscale network modeling of oligodendrocytes reveals molecular components of myelin dysregulation in Alzheimer's disease. Molecular Neurodegeneration. 12: 82. PMID 29110684 DOI: 10.1186/S13024-017-0219-3  1
2017 Li SD, Ma M, Li H, Waluszko A, Sidorenko T, Schadt EE, Zhang DY, Chen R, Ye F. Cancer gene profiling in non-small cell lung cancers reveals activating mutations in JAK2 and JAK3 with therapeutic implications. Genome Medicine. 9: 89. PMID 29082853 DOI: 10.1186/S13073-017-0478-1  1
2017 Ortiz-Virumbrales M, Moreno CL, Kruglikov I, Marazuela P, Sproul A, Jacob S, Zimmer M, Paull D, Zhang B, Schadt EE, Ehrlich ME, Tanzi RE, Arancio O, Noggle S, Gandy S. CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer's PSEN2 (N141I) neurons. Acta Neuropathologica Communications. 5: 77. PMID 29078805 DOI: 10.1186/S40478-017-0475-Z  1
2017 Scott SA, Obeng AO, Botton MR, Yang Y, Scott ER, Ellis SB, Wallsten R, Kaszemacher T, Zhou X, Chen R, Nicoletti P, Naik H, Kenny EE, Vega A, Waite E, ... ... Schadt EE, et al. Institutional profile: translational pharmacogenomics at the Icahn School of Medicine at Mount Sinai. Pharmacogenomics. PMID 28982267 DOI: 10.2217/Pgs-2017-0137  1
2017 Wang H, Bender A, Wang P, Karakose E, Inabnet WB, Libutti SK, Arnold A, Lambertini L, Stang M, Chen H, Kasai Y, Mahajan M, Kinoshita Y, Fernandez-Ranvier G, Becker TC, ... ... Schadt EE, et al. Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas. Nature Communications. 8: 767. PMID 28974674 DOI: 10.1038/S41467-017-00992-9  1
2017 Argmann CA, Violante S, Dodatko T, Amaro MP, Hagen J, Gillespie VL, Buettner C, Schadt EE, Houten SM. Germline deletion of Krüppel-like factor 14 does not increase risk of diet induced metabolic syndrome in male C57BL/6 mice. Biochimica Et Biophysica Acta. PMID 28962896 DOI: 10.1016/J.Bbadis.2017.09.021  1
2017 Peters LA, Perrigoue J, Mortha A, Iuga A, Song WM, Neiman EM, Llewellyn SR, Di Narzo A, Kidd BA, Telesco SE, Zhao Y, Stojmirovic A, Sendecki J, Shameer K, Miotto R, ... ... Schadt EE, et al. A functional genomics predictive network model identifies regulators of inflammatory bowel disease. Nature Genetics. PMID 28892060 DOI: 10.1038/Ng.3947  1
2017 Morgan RA, Beck KR, Nixon M, Homer NZM, Crawford AA, Melchers D, Houtman R, Meijer OC, Stomby A, Anderson AJ, Upreti R, Stimson RH, Olsson T, Michoel T, Cohain A, ... ... Schadt EE, et al. Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity. Scientific Reports. 7: 10633. PMID 28878267 DOI: 10.1038/S41598-017-10410-1  1
2017 Lake NJ, Webb BD, Stroud DA, Richman TR, Ruzzenente B, Compton AG, Mountford HS, Pulman J, Zangarelli C, Rio M, Bodaert N, Assouline Z, Sherpa MD, Schadt EE, Houten SM, et al. Biallelic Mutations in MRPS34 Lead to Instability of the Small Mitoribosomal Subunit and Leigh Syndrome. American Journal of Human Genetics. 101: 239-254. PMID 28777931 DOI: 10.1016/j.ajhg.2017.07.005  1
2017 Zillikens MC, Demissie S, Hsu YH, Yerges-Armstrong LM, Chou WC, Stolk L, Livshits G, Broer L, Johnson T, Koller DL, Kutalik Z, Luan J, Malkin I, Ried JS, Smith AV, ... ... Schadt EE, et al. Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. Nature Communications. 8: 80. PMID 28724990 DOI: 10.1038/S41467-017-00031-7  1
2017 Nelson CP, Goel A, Butterworth AS, Kanoni S, Webb TR, Marouli E, Zeng L, Ntalla I, Lai FY, Hopewell JC, Giannakopoulou O, Jiang T, Hamby SE, Di Angelantonio E, Assimes TL, ... ... Schadt EE, et al. Association analyses based on false discovery rate implicate new loci for coronary artery disease. Nature Genetics. PMID 28714975 DOI: 10.1038/Ng.3913  1
2017 Hauberg ME, Zhang W, Giambartolomei C, Franzén O, Morris DL, Vyse TJ, Ruusalepp A, Sklar P, Schadt EE, Björkegren JLM, Roussos P. Large-Scale Identification of Common Trait and Disease Variants Affecting Gene Expression. American Journal of Human Genetics. 101: 157. PMID 28686855 DOI: 10.1016/j.ajhg.2017.06.003  1
2017 Sahraeian SME, Mohiyuddin M, Sebra R, Tilgner H, Afshar PT, Au KF, Bani Asadi N, Gerstein MB, Wong WH, Snyder MP, Schadt E, Lam HYK. Gaining comprehensive biological insight into the transcriptome by performing a broad-spectrum RNA-seq analysis. Nature Communications. 8: 59. PMID 28680106 DOI: 10.1038/S41467-017-00050-4  1
2017 Haure-Mirande JV, Audrain M, Fanutza T, Kim SH, Klein WL, Glabe C, Readhead B, Dudley JT, Blitzer RD, Wang M, Zhang B, Schadt EE, Gandy S, Ehrlich ME. Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology. Acta Neuropathologica. PMID 28612290 DOI: 10.1007/S00401-017-1737-3  1
2017 Hauberg ME, Zhang W, Giambartolomei C, Franzén O, Morris DL, Vyse TJ, Ruusalepp A, Sklar P, Schadt EE, Björkegren JLM, Roussos P. Large-Scale Identification of Common Trait and Disease Variants Affecting Gene Expression. American Journal of Human Genetics. PMID 28552197 DOI: 10.1016/J.Ajhg.2017.04.016  1
2017 Douvaras P, Sun B, Wang M, Kruglikov I, Lallos G, Zimmer M, Terrenoire C, Zhang B, Gandy S, Schadt E, Freytes DO, Noggle S, Fossati V. Directed Differentiation of Human Pluripotent Stem Cells to Microglia. Stem Cell Reports. PMID 28528700 DOI: 10.1016/J.Stemcr.2017.04.023  1
2017 Uzilov AV, Cheesman KC, Fink MY, Newman LC, Pandya C, Lalazar Y, Hefti M, Fowkes M, Deikus G, Lau CY, Moe AS, Kinoshita Y, Kasai Y, Zweig M, Gupta A, ... ... Schadt EE, et al. Identification of a novel RASD1 somatic mutation in a USP8-mutated corticotroph adenoma. Cold Spring Harbor Molecular Case Studies. 3: a001602. PMID 28487882 DOI: 10.1101/mcs.a001602  1
2017 Badal B, Solovyov A, Di Cecilia S, Chan JM, Chang LW, Iqbal R, Aydin IT, Rajan GS, Chen C, Abbate F, Arora KS, Tanne A, Gruber SB, Johnson TM, Fullen DR, ... ... Schadt EE, et al. Transcriptional dissection of melanoma identifies a high-risk subtype underlying TP53 family genes and epigenome deregulation. Jci Insight. 2. PMID 28469092 DOI: 10.1172/Jci.Insight.92102  1
2017 Bansilal S, Vedanthan R, Kovacic JC, Soto AV, Latina J, Björkegren JLM, Jaslow R, Santana M, Sartori S, Giannarelli C, Mani V, Hajjar R, Schadt E, Kasarskis A, Fayad ZA, et al. Rationale and Design of Family-Based Approach in a Minority Community Integrating Systems-Biology for Promotion of Health (FAMILIA). American Heart Journal. 187: 170-181. PMID 28454800 DOI: 10.1016/J.Ahj.2017.02.020  1
2017 Pandya C, Uzilov AV, Bellizzi J, Lau CY, Moe AS, Strahl M, Hamou W, Newman LC, Fink MY, Antipin Y, Yu W, Stevenson M, Cavaco BM, Teh BT, Thakker RV, ... ... Schadt EE, et al. Genomic profiling reveals mutational landscape in parathyroid carcinomas. Jci Insight. 2: e92061. PMID 28352668 DOI: 10.1172/Jci.Insight.92061  1
2017 Chan YY, Wang P, Rogers L, Tignor N, Zweig M, Hershman SG, Genes N, Scott ER, Krock E, Badgeley M, Edgar R, Violante S, Wright R, Powell CA, Dudley JT, ... Schadt EE, et al. The Asthma Mobile Health Study, a large-scale clinical observational study using ResearchKit. Nature Biotechnology. PMID 28288104 DOI: 10.1038/Nbt.3826  1
2017 Webb TR, Erdmann J, Stirrups KE, Stitziel NO, Masca NG, Jansen H, Kanoni S, Nelson CP, Ferrario PG, König IR, Eicher JD, Johnson AD, Hamby SE, Betsholtz C, Ruusalepp A, ... ... Schadt EE, et al. Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease. Journal of the American College of Cardiology. 69: 823-836. PMID 28209224 DOI: 10.1016/J.Jacc.2016.11.056  1
2017 Di Narzo AF, Telesco SE, Brodmerkel C, Argmann C, Peters LA, Li K, Kidd B, Dudley J, Cho J, Schadt EE, Kasarskis A, Dobrin R, Hao K. High-Throughput Characterization of Blood Serum Proteomics of IBD Patients with Respect to Aging and Genetic Factors. Plos Genetics. 13: e1006565. PMID 28129359 DOI: 10.1371/Journal.Pgen.1006565  1
2017 Mendelson MM, Marioni RE, Joehanes R, Liu C, Hedman ÅK, Aslibekyan S, Demerath EW, Guan W, Zhi D, Yao C, Huan T, Willinger C, Chen B, Courchesne P, Multhaup M, ... ... Schadt EE, et al. Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach. Plos Medicine. 14: e1002215. PMID 28095459 DOI: 10.1371/Journal.Pmed.1002215  1
2017 Webb BD, Metikala S, Wheeler PG, Sherpa MD, Houten SM, Horb ME, Schadt EE. Heterozygous Pathogenic Variant in DACT1 Causes an Autosomal Dominant Syndrome with Features Overlapping Townes-Brocks Syndrome. Human Mutation. PMID 28054444 DOI: 10.1002/Humu.23171  1
2017 Sanderson SC, Linderman MD, Suckiel SA, Zinberg R, Wasserstein M, Kasarskis A, Diaz GA, Schadt EE. Psychological and behavioural impact of returning personal results from whole-genome sequencing: the HealthSeq project. European Journal of Human Genetics : Ejhg. PMID 28051073 DOI: 10.1038/Ejhg.2016.178  1
2017 Akers NK, Schadt EE, Losic B. Abstract 1653: Modeling tumor immuno-dynamics to predict patient survival and immunotherapy efficacy Cancer Research. 77: 1653-1653. DOI: 10.1158/1538-7445.Am2017-1653  1
2017 Dincer A, Schadt EE, Gavin D, Dudley J, Zhang B, Akbarian S. 158. Decoding Brain Epigenome Maps with Broad Histone H3K4me3 Domains: Discovering Functional Epigenetic Patterns and Their Dynamics in Gene Regulatory Networks Biological Psychiatry. 81. DOI: 10.1016/J.Biopsych.2017.02.171  1
2016 Akerman I, Tu Z, Beucher A, Rolando DM, Sauty-Colace C, Benazra M, Nakic N, Yang J, Wang H, Pasquali L, Moran I, Garcia-Hurtado J, Castro N, Gonzalez-Franco R, Stewart AF, ... ... Schadt E, et al. Human Pancreatic β Cell lncRNAs Control Cell-Specific Regulatory Networks. Cell Metabolism. PMID 28041957 DOI: 10.1016/j.cmet.2016.11.016  1
2016 Carcamo-Orive I, Hoffman GE, Cundiff P, Beckmann ND, D'Souza SL, Knowles JW, Patel A, Papatsenko D, Abbasi F, Reaven GM, Whalen S, Lee P, Shahbazi M, Henrion MY, Zhu K, ... ... Schadt EE, et al. Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity. Cell Stem Cell. PMID 28017796 DOI: 10.1016/J.Stem.2016.11.005  1
2016 Jones GT, Tromp G, Kuivaniemi H, Gretarsdottir S, Baas AF, Giusti B, Strauss E, van 't Hof FN, Webb T, Erdman R, Ritchie MD, Elmore JR, Verma A, Pendergrass S, Kullo IJ, ... ... Schadt E, et al. Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci. Circulation Research. PMID 27899403 DOI: 10.1161/Circresaha.116.308765  1
2016 Ma M, Wang C, Glicksberg BS, Schadt EE, Li SD, Chen R. IDENTIFY CANCER DRIVER GENES THROUGH SHARED MENDELIAN DISEASE PATHOGENIC VARIANTS AND CANCER SOMATIC MUTATIONS. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 22: 473-484. PMID 27896999  1
2016 Tignor N, Wang P, Genes N, Rogers L, Hershman SG, Scott ER, Zweig M, Yvonne Chan YF, Schadt EE. METHODS FOR CLUSTERING TIME SERIES DATA ACQUIRED FROM MOBILE HEALTH APPS. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 22: 300-311. PMID 27896984  1
2016 Cohain A, Divaraniya AA, Zhu K, Scarpa JR, Kasarskis A, Zhu J, Chang R, Dudley JT, Schadt EE. EXPLORING THE REPRODUCIBILITY OF PROBABILISTIC CAUSAL MOLECULAR NETWORK MODELS. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 22: 120-131. PMID 27896968 DOI: 10.1142/9789813207813_0013  1
2016 Hoffman GE, Schadt EE. variancePartition: interpreting drivers of variation in complex gene expression studies. Bmc Bioinformatics. 17: 483. PMID 27884101 DOI: 10.1186/s12859-016-1323-z  1
2016 Wang M, Roussos P, McKenzie A, Zhou X, Kajiwara Y, Brennand KJ, De Luca GC, Crary JF, Casaccia P, Buxbaum JD, Ehrlich M, Gandy S, Goate A, Katsel P, Schadt E, et al. Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer's disease. Genome Medicine. 8: 104. PMID 27799057 DOI: 10.1186/S13073-016-0355-3  1
2016 Peterson CT, Lucas J, John-Williams LS, Thompson JW, Moseley MA, Patel S, Peterson SN, Porter V, Schadt EE, Mills PJ, Tanzi RE, Doraiswamy PM, Chopra D. Corrigendum: Identification of Altered Metabolomic Profiles Following a Panchakarma-based Ayurvedic Intervention in Healthy Subjects: The Self-Directed Biological Transformation Initiative (SBTI). Scientific Reports. 6: 34678. PMID 27721380 DOI: 10.1038/srep34678  1
2016 Fromer M, Roussos P, Sieberts SK, Johnson JS, Kavanagh DH, Perumal TM, Ruderfer DM, Oh EC, Topol A, Shah HR, Klei LL, Kramer R, Pinto D, Gümüş ZH, Cicek AE, ... ... Schadt EE, et al. Gene expression elucidates functional impact of polygenic risk for schizophrenia. Nature Neuroscience. PMID 27668389 DOI: 10.1038/Nn.4399  1
2016 Peterson CT, Lucas J, John-Williams LS, Thompson JW, Moseley MA, Patel S, Peterson SN, Porter V, Schadt EE, Mills PJ, Tanzi RE, Doraiswamy PM, Chopra D. Identification of Altered Metabolomic Profiles Following a Panchakarma-based Ayurvedic Intervention in Healthy Subjects: The Self-Directed Biological Transformation Initiative (SBTI). Scientific Reports. 6: 32609. PMID 27611967 DOI: 10.1038/Srep32609  1
2016 Yang J, Huang T, Song WM, Petralia F, Mobbs CV, Zhang B, Zhao Y, Schadt EE, Zhu J, Tu Z. Discover the network mechanisms underlying the connections between aging and age-related diseases. Scientific Reports. 6: 32566. PMID 27582315 DOI: 10.1038/Srep32566  1
2016 Franzén O, Ermel R, Cohain A, Akers NK, Di Narzo A, Talukdar HA, Foroughi-Asl H, Giambartolomei C, Fullard JF, Sukhavasi K, Köks S, Gan LM, Giannarelli C, Kovacic JC, Betsholtz C, ... ... Schadt EE, et al. Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases. Science (New York, N.Y.). 353: 827-30. PMID 27540175 DOI: 10.1126/science.aad6970  1
2016 Kojima Y, Volkmer JP, McKenna K, Civelek M, Lusis AJ, Miller CL, Direnzo D, Nanda V, Ye J, Connolly AJ, Schadt EE, Quertermous T, Betancur P, Maegdefessel L, Matic LP, et al. CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis. Nature. PMID 27437576 DOI: 10.1038/Nature18935  1
2016 Miller CL, Pjanic M, Wang T, Nguyen T, Cohain A, Lee JD, Perisic L, Hedin U, Kundu RK, Majmudar D, Kim JB, Wang O, Betsholtz C, Ruusalepp A, Franzén O, ... ... Schadt EE, et al. Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci. Nature Communications. 7: 12092. PMID 27386823 DOI: 10.1038/Ncomms12092  1
2016 Kidd BA, Hoffman G, Zimmerman N, Li L, Morgan JW, Glowe PK, Botwin GJ, Parekh S, Babic N, Doust MW, Stock GB, Schadt EE, Dudley JT. Evaluation of direct-to-consumer low-volume lab tests in healthy adults. The Journal of Clinical Investigation. 126: 2773. PMID 27367185 DOI: 10.1172/JCI88464  1
2016 Mills PJ, Wilson KL, Pung MA, Weiss L, Patel S, Doraiswamy PM, Peterson C, Porter V, Schadt E, Chopra D, Tanz RE. The Self-Directed Biological Transformation Initiative and Well-Being. Journal of Alternative and Complementary Medicine (New York, N.Y.). PMID 27351443 DOI: 10.1089/acm.2016.0002  1
2016 Di Narzo AF, Peters LA, Argmann C, Stojmirovic A, Perrigoue J, Li K, Telesco S, Kidd B, Walker J, Dudley J, Cho J, Schadt EE, Kasarskis A, Curran M, Dobrin R, et al. Blood and Intestine eQTLs from an Anti-TNF-Resistant Crohn's Disease Cohort Inform IBD Genetic Association Loci. Clinical and Translational Gastroenterology. 7: e177. PMID 27336838 DOI: 10.1038/Ctg.2016.34  1
2016 Kappil MA, Li Q, Li A, Dassanayake PS, Xia Y, Nanes JA, Landrigan PJ, Stodgell CJ, Aagaard KM, Schadt EE, Dole N, Varner M, Moye J, Kasten C, Miller RK, et al. In utero exposures to environmental organic pollutants disrupt epigenetic marks linked to fetoplacental development. Environmental Epigenetics. 2. PMID 27308065 DOI: 10.1093/Eep/Dvv013  1
2016 Glicksberg BS, Li L, Badgeley MA, Shameer K, Kosoy R, Beckmann ND, Pho N, Hakenberg J, Ma M, Ayers KL, Hoffman GE, Dan Li S, Schadt EE, Patel CJ, Chen R, et al. Comparative analyses of population-scale phenomic data in electronic medical records reveal race-specific disease networks. Bioinformatics (Oxford, England). 32: i101-i110. PMID 27307606 DOI: 10.1093/Bioinformatics/Btw282  1
2016 Zook JM, Catoe D, McDaniel J, Vang L, Spies N, Sidow A, Weng Z, Liu Y, Mason CE, Alexander N, Henaff E, McIntyre AB, Chandramohan D, Chen F, Jaeger E, ... ... Schadt E, et al. Extensive sequencing of seven human genomes to characterize benchmark reference materials. Scientific Data. 3: 160025. PMID 27271295 DOI: 10.1038/Sdata.2016.25  1
2016 Uzilov AV, Ding W, Fink MY, Antipin Y, Brohl AS, Davis C, Lau CY, Pandya C, Shah H, Kasai Y, Powell J, Micchelli M, Castellanos R, Zhang Z, Linderman M, ... ... Schadt EE, et al. Development and clinical application of an integrative genomic approach to personalized cancer therapy. Genome Medicine. 8: 62. PMID 27245685 DOI: 10.1186/S13073-016-0313-0  1
2016 Talukdar HA, Foroughi Asl H, Jain RK, Ermel R, Ruusalepp A, Franzén O, Kidd BA, Readhead B, Giannarelli C, Kovacic JC, Ivert T, Dudley JT, Civelek M, Lusis AJ, Schadt EE, et al. Cross-Tissue Regulatory Gene Networks in Coronary Artery Disease. Cell Systems. 2: 196-208. PMID 27135365 DOI: 10.1016/J.Cels.2016.02.002  1
2016 Rykunov D, Beckmann ND, Li H, Uzilov A, Schadt EE, Reva B. A new molecular signature method for prediction of driver cancer pathways from transcriptional data. Nucleic Acids Research. PMID 27098033 DOI: 10.1093/Nar/Gkw269  1
2016 Chen R, Shi L, Hakenberg J, Naughton B, Sklar P, Zhang J, Zhou H, Tian L, Prakash O, Lemire M, Sleiman P, Cheng WY, Chen W, Shah H, Shen Y, ... ... Schadt EE, et al. Analysis of 589,306 genomes identifies individuals resilient to severe Mendelian childhood diseases. Nature Biotechnology. PMID 27065010 DOI: 10.1038/Nbt.3514  1
2016 Vedanthan R, Bansilal S, Soto AV, Kovacic JC, Latina J, Jaslow R, Santana M, Gorga E, Kasarskis A, Hajjar R, Schadt EE, Björkegren JL, Fayad ZA, Fuster V. Family-Based Approaches to Cardiovascular Health Promotion. Journal of the American College of Cardiology. 67: 1725-37. PMID 27056780 DOI: 10.1016/J.Jacc.2016.01.036  1
2016 Kidd BA, Hoffman G, Zimmerman N, Li L, Morgan JW, Glowe PK, Botwin GJ, Parekh S, Babic N, Doust MW, Stock GB, Schadt EE, Dudley JT. Evaluation of direct-to-consumer low-volume lab tests in healthy adults. The Journal of Clinical Investigation. PMID 27018593 DOI: 10.1172/Jci86318  1
2016 Suckiel SA, Linderman MD, Sanderson SC, Diaz GA, Wasserstein M, Kasarskis A, Schadt EE, Zinberg RE. Impact of Genomic Counseling on Informed Decision-Making among ostensibly Healthy Individuals Seeking Personal Genome Sequencing: the HealthSeq Project. Journal of Genetic Counseling. PMID 26898680 DOI: 10.1007/S10897-016-9935-Z  1
2016 Li Q, Lee CH, Peters LA, Mastropaolo LA, Thoeni C, Elkadri A, Schwerd T, Zhu J, Zhang B, Zhao Y, Hao K, Dinarzo A, Hoffman G, Kidd BA, Murchie R, ... ... Schadt EE, et al. Variants in TRIM22 that Affect NOD2 Signaling Are Associated With Very Early Onset Inflammatory Bowel Disease. Gastroenterology. PMID 26836588 DOI: 10.1053/J.Gastro.2016.01.031  1
2016 Yang J, Huang T, Petralia F, Long Q, Zhang B, Argmann C, Zhao Y, Mobbs CV, Schadt EE, Zhu J, Tu Z. Corrigendum: Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases. Scientific Reports. 6: 19384. PMID 26795431 DOI: 10.1038/Srep19384  1
2016 Readhead B, Haure-Mirande JV, Zhang B, Haroutunian V, Gandy S, Schadt EE, Dudley JT, Ehrlich ME. Molecular systems evaluation of oligomerogenic APP(E693Q) and fibrillogenic APP(KM670/671NL)/PSEN1(Δexon9) mouse models identifies shared features with human Alzheimer's brain molecular pathology. Molecular Psychiatry. PMID 26782051 DOI: 10.1038/Mp.2015.215  1
2016 Knowles JW, Xie W, Zhang Z, Chennamsetty I, Assimes TL, Paananen J, Hansson O, Pankow J, Goodarzi MO, Carcamo-Orive I, Morris AP, Chen YI, Mäkinen VP, Ganna A, Mahajan A, ... ... Schadt EE, et al. Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene. The Journal of Clinical Investigation. 126: 403. PMID 26727231 DOI: 10.1172/Jci85921  1
2016 Akers NK, Schadt E, Losic B. Abstract A024: Predicting cancer survival with neo-epitope burden Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-A024  1
2016 Readhead B, Haure-Mirande JV, Zhang B, Haroutunian V, Gandy S, Schadt EE, Dudley JT, Ehrlich ME. Molecular systems evaluation of oligomerogenic APPE693Q and fibrillogenic APPKM670/671NL/PSEN1?exon9 mouse models identifies shared features with human Alzheimer’s brain molecular pathology Molecular Psychiatry. DOI: 10.1038/mp.2015.215  1
2016 Martignetti J, Reva B, Elena P, Camacho-Vanegas O, Rykunov D, Kendall S, Shah H, Nair N, Strahl M, Hamou W, Kalir T, Schadt E, Sebra R, Dottino P. A pre-operative, diagnostic gene panel for guiding primary treatment choices in endometrial cancer: Advancing beyond the decades-old technology of dilation and curettage (D&C) European Journal of Cancer. 61. DOI: 10.1016/S0959-8049(16)61103-6  1
2016 Gowda I, Genes N, Tignor N, Wang P, Chan YY, Hershman S, Zweig M, Charles AP, Scott E, Schadt E, Rogers L. 176 The Asthma Mobile Health Study: Wildfires and Asthma Exacerbations, Just Blowing Smoke or is There a Correlation? Annals of Emergency Medicine. 68. DOI: 10.1016/J.Annemergmed.2016.08.189  1
2015 Afshinnekoo E, Meydan C, Chowdhury S, Jaroudi D, Boyer C, Bernstein N, Maritz JM, Reeves D, Gandara J, Chhangawala S, Ahsanuddin S, Simmons A, Nessel T, Sundaresh B, Pereira E, ... ... Schadt EE, et al. Geospatial Resolution of Human and Bacterial Diversity with City-Scale Metagenomics. Cell Systems. 1: 97-97.e3. PMID 27135689 DOI: 10.1016/J.Cels.2015.07.006  1
2015 Afshinnekoo E, Meydan C, Chowdhury S, Jaroudi D, Boyer C, Bernstein N, Maritz JM, Reeves D, Gandara J, Chhangawala S, Ahsanuddin S, Simmons A, Nessel T, Sundaresh B, Pereira E, ... ... Schadt EE, et al. Modern Methods for Delineating Metagenomic Complexity. Cell Systems. 1: 6-7. PMID 27135684 DOI: 10.1016/J.Cels.2015.07.007  1
2015 Pereira E, Camacho-Vanegas O, Anand S, Sebra R, Catalina Camacho S, Garnar-Wortzel L, Nair N, Moshier E, Wooten M, Uzilov A, Chen R, Prasad-Hayes M, Zakashansky K, Beddoe AM, Schadt E, et al. Personalized Circulating Tumor DNA Biomarkers Dynamically Predict Treatment Response and Survival In Gynecologic Cancers. Plos One. 10: e0145754. PMID 26717006 DOI: 10.1371/Journal.Pone.0145754  1
2015 Argmann CA, Houten SM, Zhu J, Schadt EE. A Next Generation Multiscale View of Inborn Errors of Metabolism. Cell Metabolism. PMID 26712461 DOI: 10.1016/J.Cmet.2015.11.012  1
2015 Chao MC, Zhu S, Kimura S, Davis BM, Schadt EE, Fang G, Waldor MK. Correction: A Cytosine Methytransferase Modulates the Cell Envelope Stress Response in the Cholera Pathogen. Plos Genetics. 11: e1005739. PMID 26657207 DOI: 10.1371/Journal.Pgen.1005739  1
2015 Afshinnekoo E, Meydan C, Chowdhury S, Jaroudi D, Boyer C, Bernstein N, Maritz JM, Reeves D, Gandara J, Chhangawala S, Ahsanuddin S, Simmons A, Nessel T, Sundaresh B, Pereira E, ... ... Schadt EE, et al. Geospatial Resolution of Human and Bacterial Diversity with City-Scale Metagenomics. Cell Systems. 1: 72-87. PMID 26594662 DOI: 10.1016/J.Cels.2015.01.001  1
2015 Chao MC, Zhu S, Kimura S, Davis BM, Schadt EE, Fang G, Waldor MK. A Cytosine Methytransferase Modulates the Cell Envelope Stress Response in the Cholera Pathogen. Plos Genetics. 11: e1005666. PMID 26588462 DOI: 10.1371/Journal.Pgen.1005666  1
2015 Dincer A, Gavin DP, Xu K, Zhang B, Dudley JT, Schadt EE, Akbarian S. Deciphering H3K4me3 broad domains associated with gene-regulatory networks and conserved epigenomic landscapes in the human brain. Translational Psychiatry. 5: e679. PMID 26575220 DOI: 10.1038/Tp.2015.169  1
2015 Readhead B, Haure-Mirande JV, Zhang B, Haroutunian V, Gandy S, Schadt EE, Dudley JT, Ehrlich ME. Molecular systems evaluation of oligomerogenic APP(E693Q) and fibrillogenic APP(KM670/671NL)/PSEN1(Δexon9) mouse models identifies shared features with human Alzheimer's brain molecular pathology. Molecular Psychiatry. PMID 26552589 DOI: 10.1038/Mp.2015.167  1
2015 Sanderson SC, Linderman MD, Suckiel SA, Diaz GA, Zinberg RE, Ferryman K, Wasserstein M, Kasarskis A, Schadt EE. Motivations, concerns and preferences of personal genome sequencing research participants: Baseline findings from the HealthSeq project. European Journal of Human Genetics : Ejhg. PMID 26508568 DOI: 10.1038/Ejhg.2015.179  1
2015 Wagschal A, Najafi-Shoushtari SH, Wang L, Goedeke L, Sinha S, deLemos AS, Black JC, Ramírez CM, Li Y, Tewhey R, Hatoum I, Shah N, Lu Y, Kristo F, Psychogios N, ... ... Schadt E, et al. Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis. Nature Medicine. PMID 26501192 DOI: 10.1038/Nm.3980  1
2015 Keating BJ, Setten Jv, Jacobson PA, Holmes MV, Verma SS, Chandrupatla HR, Nair N, Gao H, Li YR, Chang B, Wong C, Phillips R, Cole BS, Mukhtar E, Zhang W, ... ... Schadt EE, et al. Design and Implementation of the International Genetics and Translational Research in Transplantation Network Transplantation. 99: 2401-2412. PMID 26479416 DOI: 10.1097/Tp.0000000000000913  1
2015 Yang J, Huang T, Petralia F, Long Q, Zhang B, Argmann C, Zhao Y, Mobbs CV, Schadt EE, Zhu J, Tu Z. Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases. Scientific Reports. 5: 15145. PMID 26477495 DOI: 10.1038/Srep15145  1
2015 Sudmant PH, Rausch T, Gardner EJ, Handsaker RE, Abyzov A, Huddleston J, Zhang Y, Ye K, Jun G, Hsi-Yang Fritz M, Konkel MK, Malhotra A, Stütz AM, Shi X, Paolo Casale F, ... ... Schadt EE, et al. An integrated map of structural variation in 2,504 human genomes. Nature. 526: 75-81. PMID 26432246 DOI: 10.1038/Nature15394  1
2015 Lee E, Ito K, Zhao Y, Schadt EE, Irie HY, Zhu J. Inferred miRNA activity identifies miRNA-mediated regulatory networks underlying multiple cancers. Bioinformatics (Oxford, England). PMID 26358730 DOI: 10.1093/Bioinformatics/Btv531  1
2015 Pak TR, Altman DR, Attie O, Sebra R, Hamula CL, Lewis M, Deikus G, Newman LC, Fang G, Hand J, Patel G, Wallach F, Schadt EE, Huprikar S, van Bakel H, et al. Whole-genome sequencing identifies emergence of a quinolone resistance mutation in a case of Stenotrophomonas maltophilia bacteremia. Antimicrobial Agents and Chemotherapy. PMID 26324280 DOI: 10.1128/Aac.01723-15  1
2015 Wang L, Gong Y, Chippada-Venkata U, Heck MM, Retz M, Nawroth R, Galsky M, Tsao CK, Schadt E, de Bono J, Olmos D, Zhu J, Oh WK. A robust blood gene expression-based prognostic model for castration-resistant prostate cancer. Bmc Medicine. 13: 201. PMID 26297150 DOI: 10.1186/S12916-015-0442-0  1
2015 Brænne I, Civelek M, Vilne B, Di Narzo A, Johnson AD, Zhao Y, Reiz B, Codoni V, Webb TR, Foroughi Asl H, Hamby SE, Zeng L, Trégouët DA, Hao K, Topol EJ, ... Schadt EE, et al. Prediction of Causal Candidate Genes in Coronary Artery Disease Loci. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 26293461 DOI: 10.1161/Atvbaha.115.306108  1
2015 Linderman MD, Bashir A, Diaz GA, Kasarskis A, Sanderson SC, Zinberg RE, Mahajan M, Shah H, Suckiel S, Zweig M, Schadt EE. Preparing the next generation of genomicists: a laboratory-style course in medical genomics. Bmc Medical Genomics. 8: 47. PMID 26264128 DOI: 10.1186/S12920-015-0124-Y  1
2015 Li Q, Kappil MA, Li A, Dassanayake PS, Darrah TH, Friedman AE, Friedman M, Lambertini L, Landrigan P, Stodgell CJ, Xia Y, Nanes JA, Aagaard KM, Schadt EE, Murray JC, et al. Exploring the associations between microRNA expression profiles and environmental pollutants in human placenta from the National Children's Study (NCS). Epigenetics. 1-10. PMID 26252056 DOI: 10.1080/15592294.2015.1066960  1
2015 Pendleton M, Sebra R, Pang AW, Ummat A, Franzen O, Rausch T, Stütz AM, Stedman W, Anantharaman T, Hastie A, Dai H, Fritz MH, Cao H, Cohain A, Deikus G, ... ... Schadt EE, et al. Assembly and diploid architecture of an individual human genome via single-molecule technologies. Nature Methods. PMID 26121404 DOI: 10.1038/Nmeth.3454  1
2015 Beaulaurier J, Zhang XS, Zhu S, Sebra R, Rosenbluh C, Deikus G, Shen N, Munera D, Waldor MK, Chess A, Blaser MJ, Schadt EE, Fang G. Single molecule-level detection and long read-based phasing of epigenetic variations in bacterial methylomes. Nature Communications. 6: 7438. PMID 26074426 DOI: 10.1038/Ncomms8438  1
2015 Sanderson SC, Linderman MD, Suckiel SA, Diaz GA, Zinberg RE, Ferryman K, Wasserstein M, Kasarskis A, Schadt EE. Motivations, concerns and preferences of personal genome sequencing research participants: Baseline findings from the HealthSeq project. European Journal of Human Genetics : Ejhg. PMID 26036856 DOI: 10.1038/Ejhg.2015.118  1
2015 Ning K, Gettler K, Zhang W, Ng SM, Bowen BM, Hyams J, Stephens MC, Kugathasan S, Denson LA, Schadt EE, Hoffman GE, Cho JH. Improved integrative framework combining association data with gene expression features to prioritize Crohn's disease genes. Human Molecular Genetics. 24: 4147-57. PMID 25935003 DOI: 10.1093/Hmg/Ddv142  1
2015 Knowles JW, Xie W, Zhang Z, Chennemsetty I, Assimes TL, Paananen J, Hansson O, Pankow J, Goodarzi MO, Carcamo-Orive I, Morris AP, Chen YD, Mäkinen VP, Ganna A, Mahajan A, ... ... Schadt EE, et al. Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene. The Journal of Clinical Investigation. 125: 1739-51. PMID 25798622 DOI: 10.1172/Jci74692  1
2015 Webb BD, Wheeler PG, Hagen JJ, Cohen N, Linderman MD, Diaz GA, Naidich TP, Rodenburg RJ, Houten SM, Schadt EE. Novel, compound heterozygous, single-nucleotide variants in MARS2 associated with developmental delay, poor growth, and sensorineural hearing loss. Human Mutation. 36: 587-92. PMID 25754315 DOI: 10.1002/Humu.22781  1
2015 Björkegren JL, Kovacic JC, Dudley JT, Schadt EE. Genome-wide significant loci: how important are they? Systems genetics to understand heritability of coronary artery disease and other common complex disorders. Journal of the American College of Cardiology. 65: 830-45. PMID 25720628 DOI: 10.1016/J.Jacc.2014.12.033  1
2015 Xu K, Schadt EE, Pollard KS, Roussos P, Dudley JT. Genomic and network patterns of schizophrenia genetic variation in human evolutionary accelerated regions. Molecular Biology and Evolution. 32: 1148-60. PMID 25681384 DOI: 10.1093/Molbev/Msv031  1
2015 Sanderson SC, Linderman MD, Zinberg R, Bashir A, Kasarskis A, Zweig M, Suckiel S, Shah H, Mahajan M, Diaz GA, Schadt EE. How do students react to analyzing their own genomes in a whole-genome sequencing course?: outcomes of a longitudinal cohort study. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 25634025 DOI: 10.1038/Gim.2014.203  1
2015 Sia D, Losic B, Moeini A, Cabellos L, Hao K, Revill K, Bonal D, Miltiadous O, Zhang Z, Hoshida Y, Cornella H, Castillo-Martin M, Pinyol R, Kasai Y, Roayaie S, ... ... Schadt E, et al. Massive parallel sequencing uncovers actionable FGFR2-PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma. Nature Communications. 6: 6087. PMID 25608663 DOI: 10.1038/Ncomms7087  1
2015 Chang R, Karr JR, Schadt EE. Causal inference in biology networks with integrated belief propagation. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 359-70. PMID 25592596  1
2015 Foroughi Asl H, Talukdar HA, Kindt AS, Jain RK, Ermel R, Ruusalepp A, Nguyen KD, Dobrin R, Reilly DF, Schunkert H, Samani NJ, Braenne I, Erdmann J, Melander O, Qi J, ... ... Schadt EE, et al. Expression quantitative trait Loci acting across multiple tissues are enriched in inherited risk for coronary artery disease. Circulation. Cardiovascular Genetics. 8: 305-15. PMID 25578447 DOI: 10.1161/Circgenetics.114.000640  1
2015 Yoo S, Takikawa S, Geraghty P, Argmann C, Campbell J, Lin L, Huang T, Tu Z, Foronjy RF, Feronjy R, Spira A, Schadt EE, Powell CA, Zhu J. Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD. Plos Genetics. 11: e1004898. PMID 25569234 DOI: 10.1371/Journal.Pgen.1004898  1
2015 Bunyavanich S, Schadt EE. Systems biology of asthma and allergic diseases: a multiscale approach. The Journal of Allergy and Clinical Immunology. 135: 31-42. PMID 25468194 DOI: 10.1016/J.Jaci.2014.10.015  1
2015 Ferguson JF, Meyer NJ, Qu L, Xue C, Liu Y, DerOhannessian SL, Rushefski M, Paschos GK, Tang S, Schadt EE, Li M, Christie JD, Reilly MP. Integrative genomics identifies 7p11.2 as a novel locus for fever and clinical stress response in humans. Human Molecular Genetics. 24: 1801-12. PMID 25416278 DOI: 10.1093/Hmg/Ddu589  1
2015 Teixeira A, Yen B, Gusella GL, Thomas AG, Mullen MP, Aberg J, Chen X, Hoshida Y, van Bakel H, Schadt E, Basler CF, García-Sastre A, Mosoian A. Prothymosin α variants isolated from CD8+ T cells and cervicovaginal fluid suppress HIV-1 replication through type I interferon induction. The Journal of Infectious Diseases. 211: 1467-75. PMID 25404520 DOI: 10.1093/Infdis/Jiu643  0.01
2015 Rubinsteyn A, Martignetti J, Pereira E, O'Donnell T, Ahuja A, Garnar-Wortzel L, Sebra R, Dottino P, Hammerbacher J, Schadt E. Heterogeneity of mutated tumor antigens in a single high grade ovarian serous carcinoma F1000research. 6. DOI: 10.7490/F1000Research.1098264.1  1
2015 Wang L, Gong Y, Chippada-Venkata U, Heck MM, Retz M, Nawroth R, Galsky M, Tsao CK, Schadt E, de Bono J, Olmos D, Zhu J, Oh WK. A robust blood gene expression-based prognostic model for castration-resistant prostate cancer Bmc Medicine. 13. DOI: 10.1186/s12916-015-0442-0  1
2015 Lee E, Ito K, Schadt EE, Irie HY, Zhu J. Abstract B2-03: Inferred miRNA activity identifies miRNA-mediated regulatory networks underlying multiple cancers Cancer Research. 75. DOI: 10.1158/1538-7445.Compsysbio-B2-03  1
2015 Xu K, Schadt EE, Pollard KS, Roussos P, Dudley JT. Genomic and network patterns of schizophrenia genetic variation in human evolutionary accelerated regions Molecular Biology and Evolution. 32: 1148-1160. DOI: 10.1093/molbev/msv031  1
2015 Afshinnekoo E, Meydan C, Chowdhury S, Jaroudi D, Boyer C, Bernstein N, Maritz JM, Reeves D, Gandara J, Chhangawala S, Ahsanuddin S, Simmons A, Nessel T, Sundaresh B, Pereira E, ... ... Schadt EE, et al. Modern Methods for Delineating Metagenomic Complexity Cell Systems. 1: 6-7. DOI: 10.1016/j.cels.2015.07.007  1
2015 Afshinnekoo E, Meydan C, Chowdhury S, Jaroudi D, Boyer C, Bernstein N, Maritz JM, Reeves D, Gandara J, Chhangawala S, Ahsanuddin S, Simmons A, Nessel T, Sundaresh B, Pereira E, ... ... Schadt EE, et al. Geospatial Resolution of Human and Bacterial Diversity with City-Scale Metagenomics Cell Systems. 1: 72-87. DOI: 10.1016/j.cels.2015.01.001  1
2014 Schadt EE, Buchanan S, Brennand KJ, Merchant KM. Evolving toward a human-cell based and multiscale approach to drug discovery for CNS disorders. Frontiers in Pharmacology. 5: 252. PMID 25520658 DOI: 10.3389/Fphar.2014.00252  1
2014 Woodard CM, Campos BA, Kuo SH, Nirenberg MJ, Nestor MW, Zimmer M, Mosharov EV, Sulzer D, Zhou H, Paull D, Clark L, Schadt EE, Sardi SP, Rubin L, Eggan K, et al. iPSC-derived dopamine neurons reveal differences between monozygotic twins discordant for Parkinson's disease. Cell Reports. 9: 1173-82. PMID 25456120 DOI: 10.1016/J.Celrep.2014.10.023  1
2014 Roussos P, Mitchell AC, Voloudakis G, Fullard JF, Pothula VM, Tsang J, Stahl EA, Georgakopoulos A, Ruderfer DM, Charney A, Okada Y, Siminovitch KA, Worthington J, Padyukov L, Klareskog L, ... ... Schadt EE, et al. A role for noncoding variation in schizophrenia. Cell Reports. 9: 1417-29. PMID 25453756 DOI: 10.1016/J.Celrep.2014.10.015  1
2014 Kennedy BK, Berger SL, Brunet A, Campisi J, Cuervo AM, Epel ES, Franceschi C, Lithgow GJ, Morimoto RI, Pessin JE, Rando TA, Richardson A, Schadt EE, Wyss-Coray T, Sierra F. Geroscience: linking aging to chronic disease. Cell. 159: 709-13. PMID 25417146 DOI: 10.1016/J.Cell.2014.10.039  1
2014 Levovitz C, Chen D, Ivansson E, Gyllensten U, Finnigan JP, Alshawish S, Zhang W, Schadt EE, Posner MR, Genden EM, Boffetta P, Sikora AG. TGFβ receptor 1: an immune susceptibility gene in HPV-associated cancer. Cancer Research. 74: 6833-44. PMID 25273091 DOI: 10.1158/0008-5472.Can-14-0602-T  1
2014 Altman DR, Sebra R, Hand J, Attie O, Deikus G, Carpini KW, Patel G, Rana M, Arvelakis A, Grewal P, Dutta J, Rose H, Shopsin B, Daefler S, Schadt E, et al. Transmission of methicillin-resistant Staphylococcus aureus via deceased donor liver transplantation confirmed by whole genome sequencing. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 14: 2640-4. PMID 25250641 DOI: 10.1111/Ajt.12897  1
2014 Neylan TC, Schadt EE, Yehuda R. Biomarkers for combat-related PTSD: focus on molecular networks from high-dimensional data. European Journal of Psychotraumatology. 5. PMID 25206954 DOI: 10.3402/Ejpt.V5.23938  0.01
2014 Yoo S, Huang T, Campbell JD, Lee E, Tu Z, Geraci MW, Powell CA, Schadt EE, Spira A, Zhu J. MODMatcher: multi-omics data matcher for integrative genomic analysis. Plos Computational Biology. 10: e1003790. PMID 25122495 DOI: 10.1371/Journal.Pcbi.1003790  1
2014 Bunyavanich S, Schadt EE, Himes BE, Lasky-Su J, Qiu W, Lazarus R, Ziniti JP, Cohain A, Linderman M, Torgerson DG, Eng CS, Pino-Yanes M, Padhukasahasram B, Yang JJ, Mathias RA, et al. Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis. Bmc Medical Genomics. 7: 48. PMID 25085501 DOI: 10.1186/1755-8794-7-48  1
2014 Narayanan M, Huynh JL, Wang K, Yang X, Yoo S, McElwee J, Zhang B, Zhang C, Lamb JR, Xie T, Suver C, Molony C, Melquist S, Johnson AD, Fan G, ... ... Schadt EE, et al. Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases. Molecular Systems Biology. 10: 743. PMID 25080494 DOI: 10.15252/Msb.20145304  1
2014 Hoffman GE, Mezey JG, Schadt EE. lrgpr: interactive linear mixed model analysis of genome-wide association studies with composite hypothesis testing and regression diagnostics in R. Bioinformatics (Oxford, England). 30: 3134-5. PMID 25035399 DOI: 10.1093/Bioinformatics/Btu435  1
2014 Soni MS, Rabaglia ME, Bhatnagar S, Shang J, Ilkayeva O, Mynatt R, Zhou YP, Schadt EE, Thornberry NA, Muoio DM, Keller MP, Attie AD. Downregulation of carnitine acyl-carnitine translocase by miRNAs 132 and 212 amplifies glucose-stimulated insulin secretion. Diabetes. 63: 3805-14. PMID 24969106 DOI: 10.2337/Db13-1677  1
2014 Shang MM, Talukdar HA, Hofmann JJ, Niaudet C, Asl HF, Jain RK, Rossignoli A, Cedergren C, Silveira A, Gigante B, Leander K, de Faire U, Hamsten A, Ruusalepp A, Melander O, ... ... Schadt EE, et al. Lim domain binding 2: a key driver of transendothelial migration of leukocytes and atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 34: 2068-77. PMID 24925974 DOI: 10.1161/Atvbaha.113.302709  1
2014 Friend SH, Schadt EE. Translational genomics. Clues from the resilient. Science (New York, N.Y.). 344: 970-2. PMID 24876479 DOI: 10.1126/Science.1255648  1
2014 Richardson AG, Schadt EE. The role of macromolecular damage in aging and age-related disease. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 69: S28-32. PMID 24833583 DOI: 10.1093/Gerona/Glu056  1
2014 Giambartolomei C, Vukcevic D, Schadt EE, Franke L, Hingorani AD, Wallace C, Plagnol V. Bayesian test for colocalisation between pairs of genetic association studies using summary statistics. Plos Genetics. 10: e1004383. PMID 24830394 DOI: 10.1371/Journal.Pgen.1004383  1
2014 Linderman MD, Brandt T, Edelmann L, Jabado O, Kasai Y, Kornreich R, Mahajan M, Shah H, Kasarskis A, Schadt EE. Analytical validation of whole exome and whole genome sequencing for clinical applications. Bmc Medical Genomics. 7: 20. PMID 24758382 DOI: 10.1186/1755-8794-7-20  1
2014 Martignetti JA, Camacho-Vanegas O, Priedigkeit N, Camacho C, Pereira E, Lin L, Garnar-Wortzel L, Miller D, Losic B, Shah H, Liao J, Ma J, Lahiri P, Chee M, Schadt E, et al. Personalized ovarian cancer disease surveillance and detection of candidate therapeutic drug target in circulating tumor DNA. Neoplasia (New York, N.Y.). 16: 97-103. PMID 24563622 DOI: 10.1593/Neo.131900  1
2014 Kojima Y, Downing K, Kundu R, Miller C, Dewey F, Lancero H, Raaz U, Perisic L, Hedin U, Schadt E, Maegdefessel L, Quertermous T, Leeper NJ. Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis. The Journal of Clinical Investigation. 124: 1083-97. PMID 24531546 DOI: 10.1172/Jci70391  1
2014 Sivendran S, Chang R, Pham L, Phelps RG, Harcharik ST, Hall LD, Bernardo SG, Moskalenko MM, Sivendran M, Fu Y, de Moll EH, Pan M, Moon JY, Arora S, Cohain A, ... ... Schadt EE, et al. Dissection of immune gene networks in primary melanoma tumors critical for antitumor surveillance of patients with stage II-III resectable disease. The Journal of Investigative Dermatology. 134: 2202-11. PMID 24522433 DOI: 10.1038/Jid.2014.85  1
2014 Holmes MV, Lange LA, Palmer T, Lanktree MB, North KE, Almoguera B, Buxbaum S, Chandrupatla HR, Elbers CC, Guo Y, Hoogeveen RC, Li J, Li YR, Swerdlow DI, Cushman M, ... ... Schadt EE, et al. Causal effects of body mass index on cardiometabolic traits and events: a Mendelian randomization analysis. American Journal of Human Genetics. 94: 198-208. PMID 24462370 DOI: 10.1016/J.Ajhg.2013.12.014  1
2014 Kidd BA, Peters LA, Schadt EE, Dudley JT. Unifying immunology with informatics and multiscale biology. Nature Immunology. 15: 118-27. PMID 24448569 DOI: 10.1038/Ni.2787  1
2014 Munera D, Ritchie JM, Hatzios SK, Bronson R, Fang G, Schadt EE, Davis BM, Waldor MK. Autotransporters but not pAA are critical for rabbit colonization by Shiga toxin-producing Escherichia coli O104:H4. Nature Communications. 5: 3080. PMID 24445323 DOI: 10.1038/Ncomms4080  1
2014 Avitzur Y, Guo C, Mastropaolo LA, Bahrami E, Chen H, Zhao Z, Elkadri A, Dhillon S, Murchie R, Fattouh R, Huynh H, Walker JL, Wales PW, Cutz E, Kakuta Y, ... ... Schadt E, et al. Mutations in tetratricopeptide repeat domain 7A result in a severe form of very early onset inflammatory bowel disease. Gastroenterology. 146: 1028-39. PMID 24417819 DOI: 10.1053/J.Gastro.2014.01.015  1
2014 Martignetti JA, Camacho-Vanegas O, Priedigkeit N, Camacho-Vanegas C, Pereira E, Lin L, Losic B, Shah h, Liao J, Ma J, Lahiri P, Chee M, Schadt E, Dottino P. Abstract 4712: Personalized ovarian cancer surveillance and detection of a therapeutic drug target in circulating tumor DNA Cancer Research. 74: 4712-4712. DOI: 10.1158/1538-7445.Am2014-4712  1
2014 Dai X, Gong Y, Galsky MD, Schadt EE, Oh WK, Zhu J. Abstract 368: Inferred regulatory interaction network from prostate cancer reveals potential regulators coordinating progression and metastasis Cancer Research. 74: 368-368. DOI: 10.1158/1538-7445.Am2014-368  1
2014 Asselbergs F, Lord G, Snyder M, Birdwell K, Schadt E, Oetting W, Petersdorf E, MacArthur D, Shaked A, Keating B. The International Genomics & Translational Research in Transplantation Network (iGeneTrain).: Abstract# A521 Transplantation. 98: 891. DOI: 10.1097/00007890-201407151-03044  0.01
2013 Sanderson SC, Linderman MD, Kasarskis A, Bashir A, Diaz GA, Mahajan MC, Shah H, Wasserstein M, Zinberg RE, Zweig M, Schadt EE. Informed decision-making among students analyzing their personal genomes on a whole genome sequencing course: a longitudinal cohort study. Genome Medicine. 5: 113. PMID 24373383 DOI: 10.1186/Gm518  1
2013 Au KF, Sebastiano V, Afshar PT, Durruthy JD, Lee L, Williams BA, van Bakel H, Schadt EE, Reijo-Pera RA, Underwood JG, Wong WH. Characterization of the human ESC transcriptome by hybrid sequencing. Proceedings of the National Academy of Sciences of the United States of America. 110: E4821-30. PMID 24282307 DOI: 10.1073/Pnas.1320101110  1
2013 Trabzuni D, Ryten M, Emmett W, Ramasamy A, Lackner KJ, Zeller T, Walker R, Smith C, Lewis PA, Mamais A, de Silva R, Vandrovcova J, Hernandez D, Nalls MA, ... ... Schadt E, et al. Fine-mapping, gene expression and splicing analysis of the disease associated LRRK2 locus. Plos One. 8: e70724. PMID 23967090 DOI: 10.1371/Journal.Pone.0070724  1
2013 Miller CL, Anderson DR, Kundu RK, Raiesdana A, Nürnberg ST, Diaz R, Cheng K, Leeper NJ, Chen CH, Chang IS, Schadt EE, Hsiung CA, Assimes TL, Quertermous T. Disease-related growth factor and embryonic signaling pathways modulate an enhancer of TCF21 expression at the 6q23.2 coronary heart disease locus. Plos Genetics. 9: e1003652. PMID 23874238 DOI: 10.1371/Journal.Pgen.1003652  1
2013 Bilal E, Dutkowski J, Guinney J, Jang IS, Logsdon BA, Pandey G, Sauerwine BA, Shimoni Y, Moen Vollan HK, Mecham BH, Rueda OM, Tost J, Curtis C, Alvarez MJ, Kristensen VN, ... ... Schadt EE, et al. Improving breast cancer survival analysis through competition-based multidimensional modeling. Plos Computational Biology. 9: e1003047. PMID 23671412 DOI: 10.1371/Journal.Pcbi.1003047  1
2013 Zhang B, Gaiteri C, Bodea LG, Wang Z, McElwee J, Podtelezhnikov AA, Zhang C, Xie T, Tran L, Dobrin R, Fluder E, Clurman B, Melquist S, Narayanan M, Suver C, ... ... Schadt EE, et al. Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease. Cell. 153: 707-20. PMID 23622250 DOI: 10.1016/J.Cell.2013.03.030  1
2013 Feng Z, Fang G, Korlach J, Clark T, Luong K, Zhang X, Wong W, Schadt E. Detecting DNA modifications from SMRT sequencing data by modeling sequence context dependence of polymerase kinetic. Plos Computational Biology. 9: e1002935. PMID 23516341 DOI: 10.1371/Journal.Pcbi.1002935  1
2013 Gandy S, Haroutunian V, DeKosky ST, Sano M, Schadt EE. CR1 and the "vanishing amyloid" hypothesis of Alzheimer's disease. Biological Psychiatry. 73: 393-5. PMID 23399469 DOI: 10.1016/J.Biopsych.2013.01.013  1
2013 Lluch-Senar M, Luong K, Lloréns-Rico V, Delgado J, Fang G, Spittle K, Clark TA, Schadt E, Turner SW, Korlach J, Serrano L. Comprehensive methylome characterization of Mycoplasma genitalium and Mycoplasma pneumoniae at single-base resolution. Plos Genetics. 9: e1003191. PMID 23300489 DOI: 10.1371/Journal.Pgen.1003191  1
2013 Leeper NJ, Raiesdana A, Kojima Y, Kundu RK, Cheng H, Maegdefessel L, Toh R, Ahn GO, Ali ZA, Anderson DR, Miller CL, Roberts SC, Spin JM, de Almeida PE, Wu JC, ... ... Schadt EE, et al. Loss of CDKN2B promotes p53-dependent smooth muscle cell apoptosis and aneurysm formation. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: e1-e10. PMID 23162013 DOI: 10.1161/Atvbaha.112.300399  1
2013 Schadt EE, Banerjee O, Fang G, Feng Z, Wong WH, Zhang X, Kislyuk A, Clark TA, Luong K, Keren-Paz A, Chess A, Kumar V, Chen-Plotkin A, Sondheimer N, Korlach J, et al. Modeling kinetic rate variation in third generation DNA sequencing data to detect putative modifications to DNA bases. Genome Research. 23: 129-41. PMID 23093720 DOI: 10.1101/Gr.136739.111  1
2013 Finnigan JP, Rubinsteyn A, Nathanson T, Akers N, Bhardwaj N, Hammerbacher J, Losic B, Schadt E. Personalized neoantigen vaccination with synthetic long peptides F1000research. 5. DOI: 10.7490/F1000Research.1111311.1  1
2013 Weisfeld-Adams JD, Ludtke A, Scott SA, Katzsand I, Naik H, Linderman MD, Paizan-Ruiz C, Wasserstein MP, Shi L, Brandt T, McGraw CA, Kornreich R, Farrell C, Schadt EE, Lublin FD, et al. Next-generation sequencing for detection of mutations associated with rare disorders in patients meeting diagnostic criteria for primary progressive multiple sclerosis Journal of the Neurological Sciences. 333. DOI: 10.1016/J.Jns.2013.07.1325  1
2012 Tu Z, Keller MP, Zhang C, Rabaglia ME, Greenawalt DM, Yang X, Wang IM, Dai H, Bruss MD, Lum PY, Zhou YP, Kemp DM, Kendziorski C, Yandell BS, Attie AD, ... Schadt EE, et al. Integrative analysis of a cross-loci regulation network identifies App as a gene regulating insulin secretion from pancreatic islets. Plos Genetics. 8: e1003107. PMID 23236292 DOI: 10.1371/Journal.Pgen.1003107  1
2012 Fang G, Munera D, Friedman DI, Mandlik A, Chao MC, Banerjee O, Feng Z, Losic B, Mahajan MC, Jabado OJ, Deikus G, Clark TA, Luong K, Murray IA, Davis BM, ... ... Schadt EE, et al. Genome-wide mapping of methylated adenine residues in pathogenic Escherichia coli using single-molecule real-time sequencing. Nature Biotechnology. 30: 1232-9. PMID 23138224 DOI: 10.1038/Nbt.2432  1
2012 Schwartz SM, Schwartz HT, Horvath S, Schadt E, Lee SI. A systematic approach to multifactorial cardiovascular disease: causal analysis. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 2821-35. PMID 23087359 DOI: 10.1161/Atvbaha.112.300123  1
2012 Mekalanos JJ, Robins W, Ussery DW, Davis BM, Schadt E, Waldor MK. Non-O1 Vibrio cholerae unlinked to cholera in Haiti. Proceedings of the National Academy of Sciences of the United States of America. 109: E3206; author reply . PMID 23035253 DOI: 10.1073/Pnas.1212443109  1
2012 Loos RJ, Schadt EE. This I believe: gaining new insights through integrating "old" data. Frontiers in Genetics. 3: 137. PMID 23024647 DOI: 10.3389/Fgene.2012.00137  0.01
2012 Schadt EE. The changing privacy landscape in the era of big data. Molecular Systems Biology. 8: 612. PMID 22968446 DOI: 10.1038/Msb.2012.47  0.01
2012 Schadt E, Chang R. Genetics. A GPS for navigating DNA. Science (New York, N.Y.). 337: 1179-80. PMID 22955822 DOI: 10.1126/Science.1227739  1
2012 Grundberg E, Small KS, Hedman Ã…K, Nica AC, Buil A, Keildson S, Bell JT, Yang TP, Meduri E, Barrett A, Nisbett J, Sekowska M, Wilk A, Shin SY, Glass D, ... ... Schadt EE, et al. Mapping cis- and trans-regulatory effects across multiple tissues in twins. Nature Genetics. 44: 1084-9. PMID 22941192 DOI: 10.1038/Ng.2394  1
2012 Ocwieja KE, Sherrill-Mix S, Mukherjee R, Custers-Allen R, David P, Brown M, Wang S, Link DR, Olson J, Travers K, Schadt E, Bushman FD. Dynamic regulation of HIV-1 mRNA populations analyzed by single-molecule enrichment and long-read sequencing. Nucleic Acids Research. 40: 10345-55. PMID 22923523 DOI: 10.1093/Nar/Gks753  1
2012 Lo K, Raftery AE, Dombek KM, Zhu J, Schadt EE, Bumgarner RE, Yeung KY. Integrating external biological knowledge in the construction of regulatory networks from time-series expression data. Bmc Systems Biology. 6: 101. PMID 22898396 DOI: 10.1186/1752-0509-6-101  1
2012 Schadt E. Eric Schadt. Interview by H. Craig Mak. Nature Biotechnology. 30: 769-770. PMID 22871721 DOI: 10.1038/Nbt.2331  0.01
2012 Califano A, Butte AJ, Friend S, Ideker T, Schadt E. Leveraging models of cell regulation and GWAS data in integrative network-based association studies. Nature Genetics. 44: 841-7. PMID 22836096 DOI: 10.1038/Ng.2355  1
2012 Wang IM, Zhang B, Yang X, Zhu J, Stepaniants S, Zhang C, Meng Q, Peters M, He Y, Ni C, Slipetz D, Crackower MA, Houshyar H, Tan CM, Asante-Appiah E, ... ... Schadt EE, et al. Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers. Molecular Systems Biology. 8: 594. PMID 22806142 DOI: 10.1038/Msb.2012.24  1
2012 Kang HP, Morgan AA, Chen R, Schadt EE, Butte AJ. Coanalysis of GWAS with eQTLs reveals disease-tissue associations. Amia Joint Summits On Translational Science Proceedings Amia Summit On Translational Science. 2012: 35-41. PMID 22779046  1
2012 Bashir A, Klammer AA, Robins WP, Chin CS, Webster D, Paxinos E, Hsu D, Ashby M, Wang S, Peluso P, Sebra R, Sorenson J, Bullard J, Yen J, Valdovino M, ... ... Schadt EE, et al. A hybrid approach for the automated finishing of bacterial genomes. Nature Biotechnology. 30: 701-7. PMID 22750883 DOI: 10.1038/Nbt.2288  1
2012 Wang CY, Stapleton DS, Schueler KL, Rabaglia ME, Oler AT, Keller MP, Kendziorski CM, Broman KW, Yandell BS, Schadt EE, Attie AD. Tsc2, a positional candidate gene underlying a quantitative trait locus for hepatic steatosis. Journal of Lipid Research. 53: 1493-501. PMID 22628617 DOI: 10.1194/Jlr.M025239  1
2012 Kang HP, Yang X, Chen R, Zhang B, Corona E, Schadt EE, Butte AJ. Integration of disease-specific single nucleotide polymorphisms, expression quantitative trait loci and coexpression networks reveal novel candidate genes for type 2 diabetes. Diabetologia. 55: 2205-13. PMID 22584726 DOI: 10.1007/S00125-012-2568-3  1
2012 Zhu J, Sova P, Xu Q, Dombek KM, Xu EY, Vu H, Tu Z, Brem RB, Bumgarner RE, Schadt EE. Stitching together multiple data dimensions reveals interacting metabolomic and transcriptomic networks that modulate cell regulation. Plos Biology. 10: e1001301. PMID 22509135 DOI: 10.1371/Journal.Pbio.1001301  1
2012 Smith CC, Wang Q, Chin CS, Salerno S, Damon LE, Levis MJ, Perl AE, Travers KJ, Wang S, Hunt JP, Zarrinkar PP, Schadt EE, Kasarskis A, Kuriyan J, Shah NP. Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia Nature. 484: 260-263. PMID 22504184 DOI: 10.1038/Nature11016  1
2012 Schadt EE, Woo S, Hao K. Bayesian method to predict individual SNP genotypes from gene expression data. Nature Genetics. 44: 603-8. PMID 22484626 DOI: 10.1038/Ng.2248  1
2012 Salm MP, Horswell SD, Hutchison CE, Speedy HE, Yang X, Liang L, Schadt EE, Cookson WO, Wierzbicki AS, Naoumova RP, Shoulders CC. The origin, global distribution, and functional impact of the human 8p23 inversion polymorphism. Genome Research. 22: 1144-53. PMID 22399572 DOI: 10.1101/Gr.126037.111  1
2012 Casellas J, Gularte RJ, Farber CR, Varona L, Mehrabian M, Schadt EE, Lusis AJ, Attie AD, Yandell BS, Medrano JF. Genome scans for transmission ratio distortion regions in mice. Genetics. 191: 247-59. PMID 22367040 DOI: 10.1534/Genetics.111.135988  1
2012 Schadt EE, Björkegren JL. NEW: network-enabled wisdom in biology, medicine, and health care. Science Translational Medicine. 4: 115rv1. PMID 22218693 DOI: 10.1126/Scitranslmed.3002132  1
2012 Davis RC, van Nas A, Castellani LW, Zhao Y, Zhou Z, Wen P, Yu S, Qi H, Rosales M, Schadt EE, Broman KW, Péterfy M, Lusis AJ. Systems genetics of susceptibility to obesity-induced diabetes in mice. Physiological Genomics. 44: 1-13. PMID 22010005 DOI: 10.1152/Physiolgenomics.00003.2011  1
2012 Langfelder P, Castellani LW, Zhou Z, Paul E, Davis R, Schadt EE, Lusis AJ, Horvath S, Mehrabian M. A systems genetic analysis of high density lipoprotein metabolism and network preservation across mouse models. Biochimica Et Biophysica Acta. 1821: 435-47. PMID 21807117 DOI: 10.1016/J.Bbalip.2011.07.014  1
2011 Kasarskis A, Yang X, Schadt E. Integrative genomics strategies to elucidate the complexity of drug response Pharmacogenomics. 12: 1695-1715. PMID 22118053 DOI: 10.2217/Pgs.11.115  1
2011 Yeung KY, Dombek KM, Lo K, Mittler JE, Zhu J, Schadt EE, Bumgarner RE, Raftery AE. Construction of regulatory networks using expression time-series data of a genotyped population. Proceedings of the National Academy of Sciences of the United States of America. 108: 19436-41. PMID 22084118 DOI: 10.1073/Pnas.1116442108  1
2011 Hao K, Lamb J, Zhang C, Xie T, Wang K, Zhang B, Chudin E, Lee NP, Mao M, Zhong H, Greenawalt D, Ferguson MD, Ng IO, Sham PC, Poon RT, ... ... Schadt EE, et al. Clinicopathologic and gene expression parameters predict liver cancer prognosis. Bmc Cancer. 11: 481. PMID 22070665 DOI: 10.1186/1471-2407-11-481  1
2011 Millstein J, Winrow CJ, Kasarskis A, Owens JR, Zhou L, Summa KC, Fitzpatrick K, Zhang B, Vitaterna MH, Schadt EE, Renger JJ, Turek FW. Identification of causal genes, networks, and transcriptional regulators of REM sleep and wake. Sleep. 34: 1469-77. PMID 22043117 DOI: 10.5665/Sleep.1378  1
2011 Patwari P, Emilsson V, Schadt EE, Chutkow WA, Lee S, Marsili A, Zhang Y, Dobrin R, Cohen DE, Larsen PR, Zavacki AM, Fong LG, Young SG, Lee RT. The arrestin domain-containing 3 protein regulates body mass and energy expenditure. Cell Metabolism. 14: 671-83. PMID 21982743 DOI: 10.1016/J.Cmet.2011.08.011  1
2011 Dobrin R, Greenawalt DM, Hu G, Kemp DM, Kaplan LM, Schadt EE, Emilsson V. Dissecting cis regulation of gene expression in human metabolic tissues. Plos One. 6: e23480. PMID 21912597 DOI: 10.1371/Journal.Pone.0023480  1
2011 Tran LM, Zhang B, Zhang Z, Zhang C, Xie T, Lamb JR, Dai H, Schadt EE, Zhu J. Inferring causal genomic alterations in breast cancer using gene expression data. Bmc Systems Biology. 5: 121. PMID 21806811 DOI: 10.1186/1752-0509-5-121  1
2011 Rasko DA, Webster DR, Sahl JW, Bashir A, Boisen N, Scheutz F, Paxinos EE, Sebra R, Chin CS, Iliopoulos D, Klammer A, Peluso P, Lee L, Kislyuk AO, Bullard J, ... ... Schadt EE, et al. Origins of the E. coli strain causing an outbreak of hemolytic-uremic syndrome in Germany. The New England Journal of Medicine. 365: 709-17. PMID 21793740 DOI: 10.1056/Nejmoa1106920  1
2011 Lamb JR, Zhang C, Xie T, Wang K, Zhang B, Hao K, Chudin E, Fraser HB, Millstein J, Ferguson M, Suver C, Ivanovska I, Scott M, Philippar U, Bansal D, ... ... Schadt EE, et al. Predictive genes in adjacent normal tissue are preferentially altered by sCNV during tumorigenesis in liver cancer and may rate limiting. Plos One. 6: e20090. PMID 21750698 DOI: 10.1371/Journal.Pone.0020090  1
2011 Su WL, Kleinhanz RR, Schadt EE. Characterizing the role of miRNAs within gene regulatory networks using integrative genomics techniques. Molecular Systems Biology. 7: 490. PMID 21613979 DOI: 10.1038/Msb.2011.23  1
2011 Greenawalt DM, Dobrin R, Chudin E, Hatoum IJ, Suver C, Beaulaurier J, Zhang B, Castro V, Zhu J, Sieberts SK, Wang S, Molony C, Heymsfield SB, Kemp DM, Reitman ML, ... ... Schadt EE, et al. A survey of the genetics of stomach, liver, and adipose gene expression from a morbidly obese cohort. Genome Research. 21: 1008-16. PMID 21602305 DOI: 10.1101/Gr.112821.110  1
2011 Fraser HB, Babak T, Tsang J, Zhou Y, Zhang B, Mehrabian M, Schadt EE. Systematic detection of polygenic cis-regulatory evolution. Plos Genetics. 7: e1002023. PMID 21483757 DOI: 10.1371/Journal.Pgen.1002023  1
2011 Speliotes EK, Yerges-Armstrong LM, Wu J, Hernaez R, Kim LJ, Palmer CD, Gudnason V, Eiriksdottir G, Garcia ME, Launer LJ, Nalls MA, Clark JM, Mitchell BD, Shuldiner AR, Butler JL, ... ... Schadt EE, et al. Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. Plos Genetics. 7: e1001324. PMID 21423719 DOI: 10.1371/Journal.Pgen.1001324  1
2011 Ma H, Schadt EE, Kaplan LM, Zhao H. COSINE: COndition-SpecIfic sub-NEtwork identification using a global optimization method. Bioinformatics (Oxford, England). 27: 1290-8. PMID 21414987 DOI: 10.1093/Bioinformatics/Btr136  1
2011 O'Brien TR, Kohaar I, Pfeiffer RM, Maeder D, Yeager M, Schadt EE, Prokunina-Olsson L. Risk alleles for chronic hepatitis B are associated with decreased mRNA expression of HLA-DPA1 and HLA-DPB1 in normal human liver. Genes and Immunity. 12: 428-33. PMID 21346778 DOI: 10.1038/Gene.2011.11  1
2011 Schadt E. First Steps on a Long Road Science. 331: 691-691. PMID 21310999 DOI: 10.1126/Science.1203235  0.01
2011 Schadt EE, Linderman MD, Sorenson J, Lee L, Nolan GP. Cloud and heterogeneous computing solutions exist today for the emerging big data problems in biology. Nature Reviews. Genetics. 12: 224. PMID 21301474 DOI: 10.1038/Nrg2857-C2  1
2011 Pichler I, Minelli C, Sanna S, Tanaka T, Schwienbacher C, Naitza S, Porcu E, Pattaro C, Busonero F, Zanon A, Maschio A, Melville SA, Grazia Piras M, Longo DL, Guralnik J, ... ... Schadt E, et al. Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels. Human Molecular Genetics. 20: 1232-40. PMID 21208937 DOI: 10.1093/Hmg/Ddq552  1
2011 Chin CS, Sorenson J, Harris JB, Robins WP, Charles RC, Jean-Charles RR, Bullard J, Webster DR, Kasarskis A, Peluso P, Paxinos EE, Yamaichi Y, Calderwood SB, Mekalanos JJ, Schadt EE, et al. The origin of the Haitian cholera outbreak strain. The New England Journal of Medicine. 364: 33-42. PMID 21142692 DOI: 10.1056/Nejmoa1012928  1
2011 Wang P, Dawson JA, Keller MP, Yandell BS, Thornberry NA, Zhang BB, Wang IM, Schadt EE, Attie AD, Kendziorski C. A model selection approach for expression quantitative trait loci (eQTL) mapping. Genetics. 187: 611-21. PMID 21115971 DOI: 10.1534/Genetics.110.122796  1
2011 Smith CC, Brown M, Chin J, Kasap C, Salerno S, Damon LE, Travers K, Wang S, Kasarskis A, Schadt E, Shah N. Single Molecule Real Time (SMRT™) Sequencing Sensitively Detects Polyclonal and Compound BCR-ABL in Patients Who Relapse on Kinase Inhibitor Therapy, Blood. 118: 3752-3752. DOI: 10.1182/Blood.V118.21.3752.3752  1
2011 Zhang B, Derry J, Schadt E, Friend S, Zhu J, Dai X, Wang Z, Meng F, Tran L, Zhang Z, Guinney J, Clurman B, Wu G. Abstract PR8: From prediction to prognosis and therapeutics: The power of breast cancer transcriptional networks Cancer Research. 71. DOI: 10.1158/1538-7445.Fbcr11-Pr8  1
2011 Califano A, Butte A, Friend S, Ideker T, Schadt EE. Integrative Network-based Association Studies: Leveraging cell regulatory models in the post-GWAS era Nature Precedings. DOI: 10.1038/Npre.2011.5732.1  1
2010 Derry JM, Zhong H, Molony C, MacNeil D, Guhathakurta D, Zhang B, Mudgett J, Small K, El Fertak L, Guimond A, Selloum M, Zhao W, Champy MF, Monassier L, Vogt T, ... ... Schadt EE, et al. Identification of genes and networks driving cardiovascular and metabolic phenotypes in a mouse F2 intercross. Plos One. 5: e14319. PMID 21179467 DOI: 10.1371/Journal.Pone.0014319  1
2010 Schadt EE, Turner S, Kasarskis A. A window into third-generation sequencing. Human Molecular Genetics. 19: R227-40. PMID 20858600 DOI: 10.1093/Hmg/Ddq416  1
2010 Pandey G, Zhang B, Chang AN, Myers CL, Zhu J, Kumar V, Schadt EE. An integrative multi-network and multi-classifier approach to predict genetic interactions. Plos Computational Biology. 6. PMID 20838583 DOI: 10.1371/Journal.Pcbi.1000928  1
2010 Listgarten J, Kadie C, Schadt EE, Heckerman D. Correction for hidden confounders in the genetic analysis of gene expression. Proceedings of the National Academy of Sciences of the United States of America. 107: 16465-70. PMID 20810919 DOI: 10.1073/Pnas.1002425107  1
2010 Shebl FM, Maeder D, Shao Y, Prokunina-Olsson L, Schadt EE, O'Brien TR. In the absence of HCV infection, interferon stimulated gene expression in liver is not associated with IL28B genotype. Gastroenterology. 139: 1422-4. PMID 20800110 DOI: 10.1053/J.Gastro.2010.07.055  1
2010 Schadt EE, Linderman MD, Sorenson J, Lee L, Nolan GP. Computational solutions to large-scale data management and analysis. Nature Reviews. Genetics. 11: 647-57. PMID 20717155 DOI: 10.1038/Nrg2857  1
2010 Babak T, Garrett-Engele P, Armour CD, Raymond CK, Keller MP, Chen R, Rohl CA, Johnson JM, Attie AD, Fraser HB, Schadt EE. Genetic validation of whole-transcriptome sequencing for mapping expression affected by cis-regulatory variation. Bmc Genomics. 11: 473. PMID 20707912 DOI: 10.1186/1471-2164-11-473  1
2010 Musunuru K, Strong A, Frank-Kamenetsky M, Lee NE, Ahfeldt T, Sachs KV, Li X, Li H, Kuperwasser N, Ruda VM, Pirruccello JP, Muchmore B, Prokunina-Olsson L, Hall JL, Schadt EE, et al. From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature. 466: 714-9. PMID 20686566 DOI: 10.1038/Nature09266  1
2010 Dudley JT, Schadt E, Sirota M, Butte AJ, Ashley E. Drug discovery in a multidimensional world: systems, patterns, and networks. Journal of Cardiovascular Translational Research. 3: 438-47. PMID 20677029 DOI: 10.1007/S12265-010-9214-6  1
2010 Nilsson EE, Savenkova MI, Schindler R, Zhang B, Schadt EE, Skinner MK. Gene bionetwork analysis of ovarian primordial follicle development. Plos One. 5: e11637. PMID 20661288 DOI: 10.1371/Journal.Pone.0011637  1
2010 Davis DB, Lavine JA, Suhonen JI, Krautkramer KA, Rabaglia ME, Sperger JM, Fernandez LA, Yandell BS, Keller MP, Wang IM, Schadt EE, Attie AD. FoxM1 is up-regulated by obesity and stimulates beta-cell proliferation. Molecular Endocrinology (Baltimore, Md.). 24: 1822-34. PMID 20660304 DOI: 10.1210/Me.2010-0082  1
2010 Vergeer M, Boekholdt SM, Sandhu MS, Ricketts SL, Wareham NJ, Brown MJ, de Faire U, Leander K, Gigante B, Kavousi M, Hofman A, Uitterlinden AG, van Duijn CM, Witteman JC, Jukema JW, ... Schadt EE, et al. Genetic variation at the phospholipid transfer protein locus affects its activity and high-density lipoprotein size and is a novel marker of cardiovascular disease susceptibility. Circulation. 122: 470-7. PMID 20644014 DOI: 10.1161/Circulationaha.109.912519  1
2010 Yang X, Peterson L, Thieringer R, Deignan JL, Wang X, Zhu J, Wang S, Zhong H, Stepaniants S, Beaulaurier J, Wang IM, Rosa R, Cumiskey AM, Luo JM, Luo Q, ... ... Schadt EE, et al. Identification and validation of genes affecting aortic lesions in mice. The Journal of Clinical Investigation. 120: 2414-22. PMID 20577049 DOI: 10.1172/Jci42742  1
2010 Hsu YH, Zillikens MC, Wilson SG, Farber CR, Demissie S, Soranzo N, Bianchi EN, Grundberg E, Liang L, Richards JB, Estrada K, Zhou Y, van Nas A, Moffatt MF, Zhai G, ... ... Schadt EE, et al. An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits. Plos Genetics. 6: e1000977. PMID 20548944 DOI: 10.1371/Journal.Pgen.1000977  1
2010 Yang X, Zhang B, Molony C, Chudin E, Hao K, Zhu J, Gaedigk A, Suver C, Zhong H, Leeder JS, Guengerich FP, Strom SC, Schuetz E, Rushmore TH, Ulrich RG, ... ... Schadt EE, et al. Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver. Genome Research. 20: 1020-36. PMID 20538623 DOI: 10.1101/Gr.103341.109  1
2010 Zhong H, Beaulaurier J, Lum PY, Molony C, Yang X, Macneil DJ, Weingarth DT, Zhang B, Greenawalt D, Dobrin R, Hao K, Woo S, Fabre-Suver C, Qian S, Tota MR, ... ... Schadt EE, et al. Liver and adipose expression associated SNPs are enriched for association to type 2 diabetes. Plos Genetics. 6: e1000932. PMID 20463879 DOI: 10.1371/Journal.Pgen.1000932  1
2010 van Nas A, Ingram-Drake L, Sinsheimer JS, Wang SS, Schadt EE, Drake T, Lusis AJ. Expression quantitative trait loci: replication, tissue- and sex-specificity in mice. Genetics. 185: 1059-68. PMID 20439777 DOI: 10.1534/Genetics.110.116087  1
2010 Narayanan M, Vetta A, Schadt EE, Zhu J. Simultaneous clustering of multiple gene expression and physical interaction datasets. Plos Computational Biology. 6: e1000742. PMID 20419151 DOI: 10.1371/Journal.Pcbi.1000742  1
2010 Zhu J, Chen Y, Leonardson AS, Wang K, Lamb JR, Emilsson V, Schadt EE. Characterizing dynamic changes in the human blood transcriptional network. Plos Computational Biology. 6: e1000671. PMID 20168994 DOI: 10.1371/Journal.Pcbi.1000671  1
2010 Xie T, Zhang C, Zhang B, Molony C, Oudes A, Roberts C, Dai H, Schadt E, Lamb J. A survey of cancer cell lines reveals highly structured and hierarchical relationships within and between DNA and mRNA that may be the result of selection Omics a Journal of Integrative Biology. 14: 91-97. PMID 20141331 DOI: 10.1089/Omi.2009.0114  1
2010 Su W, Sieberts SK, Kleinhanz RR, Lux K, Millstein J, Molony C, Schadt EE. Assessing the prospects of genome-wide association studies performed in inbred mice. Mammalian Genome. 21: 143-152. PMID 20135320 DOI: 10.1007/S00335-010-9249-7  1
2010 Fraser HB, Moses AM, Schadt EE. Evidence for widespread adaptive evolution of gene expression in budding yeast. Proceedings of the National Academy of Sciences of the United States of America. 107: 2977-82. PMID 20133628 DOI: 10.1073/Pnas.0912245107  1
2010 Zhang W, Zhu J, Schadt EE, Liu JS. A Bayesian partition method for detecting pleiotropic and epistatic eQTL modules. Plos Computational Biology. 6: e1000642. PMID 20090830 DOI: 10.1371/Journal.Pcbi.1000642  1
2010 Hao K, Chudin E, Greenawalt D, Schadt EE. Magnitude of stratification in human populations and impacts on genome wide association studies. Plos One. 5: e8695. PMID 20084173 DOI: 10.1371/Journal.Pone.0008695  1
2010 Fraser HB, Schadt EE. The quantitative genetics of phenotypic robustness. Plos One. 5: e8635. PMID 20072615 DOI: 10.1371/Journal.Pone.0008635  1
2010 Stone DJ, Molony C, Suver C, Schadt EE, Potter WZ. ApoE genotyping as a progression-rate biomarker in phase II disease-modification trials for Alzheimer's disease. The Pharmacogenomics Journal. 10: 161-4. PMID 19997085 DOI: 10.1038/Tpj.2009.58  1
2010 Leonardson AS, Zhu J, Chen Y, Wang K, Lamb JR, Reitman M, Emilsson V, Schadt EE. The effect of food intake on gene expression in human peripheral blood. Human Molecular Genetics. 19: 159-69. PMID 19837700 DOI: 10.1093/Hmg/Ddp476  1
2010 Schadt E. Abstract 2011: Separating the signal from the noise: DNA variation as a perturbagen distinguishes between causal and follower genes associated with tumorigenesis and progression in a heptacellular carcinoma (HCC) cohort Cancer Research. 70: 2011-2011. DOI: 10.1158/1538-7445.Am10-2011  0.01
2010 Cotsapas C, Speliotes EK, Hatoum IJ, Greenawalt DM, Dobrin R, Lum PY, Suver C, Chudin E, Kemp D, Reitman M, Voight BF, Neale BM, Schadt EE, Hirschhorn JN, Kaplan LM, et al. Corrigendum to Common body mass index-associated variants confer risk of extreme obesity [Human Molecular Genetics, 2009; 18;18, 3502-3507, 10.1093/hmg/ddp292] Human Molecular Genetics. 19: 3690-3691. DOI: 10.1093/Hmg/Ddq287  1
2010 Nilsson EE, Savenkova MI, Schindler R, Zhang B, Schadt EE, Skinner MK. Gene Bionetwork Analysis of Ovarian Primordial Follicle Development. Biology of Reproduction. 83: 622-622. DOI: 10.1093/Biolreprod/83.S1.622  1
2010 Fraser HB, Moses AM, Schadt EE. Reply to Jensen and Rando: Population size change does not account for widespread gene expression adaptation in yeast Proceedings of the National Academy of Sciences of the United States of America. 107: E111. DOI: 10.1073/Pnas.1006152107  1
2010 O'Brien T, Kohaar I, Pfeiffer R, Maeder D, Yeager M, Prokunina-Olsson L, Schadt E. 730 Human Genetic Variants Linked To Chronic Hepatitis B Are Associated With Expression Of Hla-Dpa1 And Hla-Dpb1 Journal of Hepatology. 52. DOI: 10.1016/S0168-8278(10)60732-5  1
2009 Wang SS, Martin LJ, Schadt EE, Meng H, Wang X, Zhao W, Ingram-Drake L, Nebohacova M, Mehrabian M, Drake TA, Lusis AJ. Disruption of the aortic elastic lamina and medial calcification share genetic determinants in mice. Circulation. Cardiovascular Genetics. 2: 573-82. PMID 20031637 DOI: 10.1161/Circgenetics.109.860270  1
2009 Wang K, Narayanan M, Zhong H, Tompa M, Schadt EE, Zhu J. Meta-analysis of inter-species liver co-expression networks elucidates traits associated with common human diseases. Plos Computational Biology. 5: e1000616. PMID 20019805 DOI: 10.1371/Journal.Pcbi.1000616  1
2009 Argmann C, Dobrin R, Heikkinen S, Auburtin A, Pouilly L, Cock TA, Koutnikova H, Zhu J, Schadt EE, Auwerx J. Ppargamma2 is a key driver of longevity in the mouse. Plos Genetics. 5: e1000752. PMID 19997628 DOI: 10.1371/Journal.Pgen.1000752  1
2009 Hägg S, Skogsberg J, Lundström J, Noori P, Nilsson R, Zhong H, Maleki S, Shang MM, Brinne B, Bradshaw M, Bajic VB, Samnegård A, Silveira A, Kaplan LM, Gigante B, ... ... Schadt EE, et al. Multi-organ expression profiling uncovers a gene module in coronary artery disease involving transendothelial migration of leukocytes and LIM domain binding 2: the Stockholm Atherosclerosis Gene Expression (STAGE) study. Plos Genetics. 5: e1000754. PMID 19997623 DOI: 10.1371/Journal.Pgen.1000754  1
2009 Schadt EE. Molecular networks as sensors and drivers of common human diseases Nature. 461: 218-223. PMID 19741703 DOI: 10.1038/Nature08454  0.01
2009 Zhao E, Keller MP, Rabaglia ME, Oler AT, Stapleton DS, Schueler KL, Neto EC, Moon JY, Wang P, Wang IM, Lum PY, Ivanovska I, Cleary M, Greenawalt D, Tsang J, ... ... Schadt EE, et al. Obesity and genetics regulate microRNAs in islets, liver, and adipose of diabetic mice. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 20: 476-85. PMID 19727952 DOI: 10.1007/S00335-009-9217-2  1
2009 Mamane Y, Chung Chan C, Lavallee G, Morin N, Xu LJ, Huang J, Gordon R, Thomas W, Lamb J, Schadt EE, Kennedy BP, Mancini JA. The C3a anaphylatoxin receptor is a key mediator of insulin resistance and functions by modulating adipose tissue macrophage infiltration and activation. Diabetes. 58: 2006-17. PMID 19581423 DOI: 10.2337/Db09-0323  1
2009 Cotsapas C, Speliotes EK, Hatoum IJ, Greenawalt DM, Dobrin R, Lum PY, Suver C, Chudin E, Kemp D, Reitman M, Voight BF, Neale BM, Schadt EE, Hirschhorn JN, Kaplan LM, et al. Common body mass index-associated variants confer risk of extreme obesity. Human Molecular Genetics. 18: 3502-7. PMID 19553259 DOI: 10.1093/Hmg/Ddp292  1
2009 Hao K, Chudin E, McElwee J, Schadt EE. Accuracy of genome-wide imputation of untyped markers and impacts on statistical power for association studies. Bmc Genetics. 10: 27. PMID 19531258 DOI: 10.1186/1471-2156-10-27  1
2009 Millstein J, Zhang B, Zhu J, Schadt EE. Disentangling molecular relationships with a causal inference test Bmc Genetics. 10. PMID 19473544 DOI: 10.1186/1471-2156-10-23  1
2009 Dobrin R, Zhu J, Molony C, Argman C, Parrish ML, Carlson S, Allan MF, Pomp D, Schadt EE. Multi-tissue coexpression networks reveal unexpected subnetworks associated with disease. Genome Biology. 10: R55. PMID 19463160 DOI: 10.1186/Gb-2009-10-5-R55  1
2009 Schadt EE, Zhang B, Zhu J. Advances in systems biology are enhancing our understanding of disease and moving us closer to novel disease treatments Genetica. 136: 259-269. PMID 19363597 DOI: 10.1007/S10709-009-9359-X  1
2009 Winrow CJ, Williams DL, Kasarskis A, Millstein J, Laposky AD, Yang HS, Mrazek K, Zhou L, Owens JR, Radzicki D, Preuss F, Schadt EE, Shimomura K, Vitaterna MH, Zhang C, et al. Uncovering the genetic landscape for multiple sleep-wake traits. Plos One. 4: e5161. PMID 19360106 DOI: 10.1371/Journal.Pone.0005161  1
2009 Schadt EE, Friend SH, Shaywitz DA. A network view of disease and compound screening Nature Reviews Drug Discovery. 8: 286-295. PMID 19337271 DOI: 10.1038/Nrd2826  1
2009 Scheinfeldt LB, Biswas S, Madeoy J, Connelly CF, Schadt EE, Akey JM. Population genomic analysis of ALMS1 in humans reveals a surprisingly complex evolutionary history. Molecular Biology and Evolution. 26: 1357-67. PMID 19279085 DOI: 10.1093/Molbev/Msp045  1
2009 Yang X, Deignan JL, Qi H, Zhu J, Qian S, Zhong J, Torosyan G, Majid S, Falkard B, Kleinhanz RR, Karlsson J, Castellani LW, Mumick S, Wang K, Xie T, ... ... Schadt EE, et al. Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks. Nature Genetics. 41: 415-23. PMID 19270708 DOI: 10.1038/Ng.325  1
2009 Tu Z, Argmann C, Wong KK, Mitnaul LJ, Edwards S, Sach IC, Zhu J, Schadt EE. Integrating siRNA and protein-protein interaction data to identify an expanded insulin signaling network. Genome Research. 19: 1057-67. PMID 19261841 DOI: 10.1101/Gr.087890.108  1
2009 Vansteelandt S, Goetgeluk S, Lutz S, Waldman I, Lyon H, Schadt EE, Weiss ST, Lange C. On the adjustment for covariates in genetic association analysis: a novel, simple principle to infer direct causal effects. Genetic Epidemiology. 33: 394-405. PMID 19219893 DOI: 10.1002/Gepi.20393  1
2009 Lum PY, Derry JMJ, Schadt EE. Integrative genomics and drug development Pharmacogenomics. 10: 203-212. PMID 19207021 DOI: 10.2217/14622416.10.2.203  1
2009 Loboda A, Kraft WK, Fine B, Joseph J, Nebozhyn M, Zhang C, He Y, Yang X, Wright C, Morris M, Chalikonda I, Ferguson M, Emilsson V, Leonardson A, Lamb J, ... ... Schadt E, et al. Diurnal variation of the human adipose transcriptome and the link to metabolic disease. Bmc Medical Genomics. 2: 7. PMID 19203388 DOI: 10.1186/1755-8794-2-7  1
2009 Heikkinen S, Argmann C, Feige JN, Koutnikova H, Champy M, Dali-Youcef N, Schadt EE, Laakso M, Auwerx J. The Pro12Ala PPARγ2 Variant Determines Metabolism at the Gene-Environment Interface Cell Metabolism. 9: 88-98. PMID 19117549 DOI: 10.1016/J.Cmet.2008.11.007  1
2009 Kathiresan S, Willer CJ, Peloso GM, Demissie S, Musunuru K, Schadt EE, Kaplan L, Bennett D, Li Y, Tanaka T, Voight BF, Bonnycastle LL, Jackson AU, Crawford G, Surti A, et al. Common variants at 30 loci contribute to polygenic dyslipidemia. Nature Genetics. 41: 56-65. PMID 19060906 DOI: 10.1038/Ng.291  1
2009 van Nas A, Guhathakurta D, Wang SS, Yehya N, Horvath S, Zhang B, Ingram-Drake L, Chaudhuri G, Schadt EE, Drake TA, Arnold AP, Lusis AJ. Elucidating the role of gonadal hormones in sexually dimorphic gene coexpression networks. Endocrinology. 150: 1235-49. PMID 18974276 DOI: 10.1210/En.2008-0563  1
2009 Farber CR, van Nas A, Ghazalpour A, Aten JE, Doss S, Sos B, Schadt EE, Ingram-Drake L, Davis RC, Horvath S, Smith DJ, Drake TA, Lusis AJ. An integrative genetics approach to identify candidate genes regulating BMD: combining linkage, gene expression, and association. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 24: 105-16. PMID 18767929 DOI: 10.1359/Jbmr.080908  1
2009 Cervino AC, Li G, Edwards S, Zhu J, Laurie C, Tokiwa G, Lum PY, Wang S, Castellani LW, Lusis AJ, Carlson S, Sachs AB, Schadt EE. Corrigendum to "Integrating QTL and high-density SNP analyses in mice to identify Insig2 as a susceptibility gene for plasma cholesterol levels" [Genomics 86 (2005) 505-517] (DOI:10.1016/j.ygeno.2005.07.010) Genomics. 93: 399. DOI: 10.1016/J.Ygeno.2008.12.005  1
2008 Keating BJ, Tischfield S, Murray SS, Bhangale T, Price TS, Glessner JT, Galver L, Barrett JC, Grant SF, Farlow DN, Chandrupatla HR, Hansen M, Ajmal S, Papanicolaou GJ, Guo Y, ... ... Schadt E, et al. Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. Plos One. 3: e3583. PMID 18974833 DOI: 10.1371/Journal.Pone.0003583  1
2008 Degnan JH, Lasky-Su J, Raby BA, Xu M, Molony C, Schadt EE, Lange C. Genomics and genome-wide association studies: an integrative approach to expression QTL mapping. Genomics. 92: 129-33. PMID 18586451 DOI: 10.1016/J.Ygeno.2008.05.012  1
2008 Hao K, Schadt EE, Storey JD. Calibrating the performance of SNP arrays for whole-genome association studies. Plos Genetics. 4: e1000109. PMID 18584036 DOI: 10.1371/Journal.Pgen.1000109  1
2008 Zhu J, Zhang B, Smith EN, Drees B, Brem RB, Kruglyak L, Bumgarner RE, Schadt EE. Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks. Nature Genetics. 40: 854-61. PMID 18552845 DOI: 10.1038/Ng.167  1
2008 Su WL, Modrek B, GuhaThakurta D, Edwards S, Shah JK, Kulkarni AV, Russell A, Schadt EE, Johnson JM, Castle JC. Exon and junction microarrays detect widespread mouse strain- and sex-bias expression differences. Bmc Genomics. 9: 273. PMID 18533039 DOI: 10.1186/1471-2164-9-273  1
2008 Schadt EE, Molony C, Chudin E, Hao K, Yang X, Lum PY, Kasarskis A, Zhang B, Wang S, Suver C, Zhu J, Millstein J, Sieberts S, Lamb J, GuhaThakurta D, et al. Mapping the genetic architecture of gene expression in human liver. Plos Biology. 6: e107. PMID 18462017 DOI: 10.1371/Journal.Pbio.0060107  1
2008 Lasky-Su J, Lyon HN, Emilsson V, Heid IM, Molony C, Raby BA, Lazarus R, Klanderman B, Soto-Quiros ME, Avila L, Silverman EK, Thorleifsson G, Thorsteinsdottir U, Kronenberg F, Vollmert C, ... ... Schadt E, et al. On the replication of genetic associations: timing can be everything! American Journal of Human Genetics. 82: 849-58. PMID 18387595 DOI: 10.1016/J.Ajhg.2008.01.018  1
2008 Zhu J, Zhang B, Schadt EE. A systems biology approach to drug discovery. Advances in Genetics. 60: 603-635. PMID 18358334 DOI: 10.1016/S0065-2660(07)00421-X  1
2008 Keller MP, Choi Y, Wang P, Davis DB, Rabaglia ME, Oler AT, Stapleton DS, Argmann C, Schueler KL, Edwards S, Steinberg HA, Chaibub Neto E, Kleinhanz R, Turner S, Hellerstein MK, ... Schadt EE, et al. A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility. Genome Research. 18: 706-16. PMID 18347327 DOI: 10.1101/Gr.074914.107  1
2008 Chen Y, Zhu J, Lum PY, Yang X, Pinto S, MacNeil DJ, Zhang C, Lamb J, Edwards S, Sieberts SK, Leonardson A, Castellini LW, Wang S, Champy MF, Zhang B, ... ... Schadt EE, et al. Variations in DNA elucidate molecular networks that cause disease. Nature. 452: 429-35. PMID 18344982 DOI: 10.1038/Nature06757  1
2008 Emilsson V, Thorleifsson G, Zhang B, Leonardson AS, Zink F, Zhu J, Carlson S, Helgason A, Walters GB, Gunnarsdottir S, Mouy M, Steinthorsdottir V, Eiriksdottir GH, Bjornsdottir G, Reynisdottir I, ... ... Schadt EE, et al. Genetics of gene expression and its effect on disease. Nature. 452: 423-8. PMID 18344981 DOI: 10.1038/Nature06758  1
2008 Feinendegen L, Hahnfeldt P, Schadt EE, Stumpf M, Voit EO. Systems biology and its potential role in radiobiology. Radiation and Environmental Biophysics. 47: 5-23. PMID 18087710 DOI: 10.1007/S00411-007-0146-8  1
2008 Schadt EE. Reconstructing The Circuits Of Disease:From Molecular States To Physiological States Genome Informatics. 21: 231-231. DOI: 10.11234/Gi1990.21.231  0.01
2008 Schadt EE. A timely guide to the genome Nature Genetics. 40: 684-684. DOI: 10.1038/Ng0608-684  0.01
2007 Fan X, Zhu J, Schadt EE, Liu JS. Statistical power of phylo-HMM for evolutionarily conserved element detection. Bmc Bioinformatics. 8: 374. PMID 17919331 DOI: 10.1186/1471-2105-8-374  1
2007 Laurie CC, Nickerson DA, Anderson AD, Weir BS, Livingston RJ, Dean MD, Smith KL, Schadt EE, Nachman MW. Linkage disequilibrium in wild mice. Plos Genetics. 3: e144. PMID 17722986 DOI: 10.1371/Journal.Pgen.0030144  1
2007 Sieberts SK, Schadt EE. Moving toward a system genetics view of disease Mammalian Genome. 18: 389-401. PMID 17653589 DOI: 10.1007/S00335-007-9040-6  1
2007 Wang SS, Schadt EE, Wang H, Wang X, Ingram-Drake L, Shi W, Drake TA, Lusis AJ. Identification of pathways for atherosclerosis in mice: integration of quantitative trait locus analysis and global gene expression data. Circulation Research. 101: e11-30. PMID 17641228 DOI: 10.1161/Circresaha.107.152975  1
2007 Davis RC, Jin A, Rosales M, Yu S, Xia X, Ranola K, Schadt EE, Lusis AJ. A genome-wide set of congenic mouse strains derived from CAST/Ei on a C57BL/6 background. Genomics. 90: 306-13. PMID 17600671 DOI: 10.1016/J.Ygeno.2007.05.009  1
2007 Reitman ML, Schadt EE. Pharmacogenetics of metformin response: a step in the path toward personalized medicine. Journal of Clinical Investigation. 117: 1226-1229. PMID 17476355 DOI: 10.1172/Jci32133  0.01
2007 Zhu J, Wiener MC, Zhang C, Fridman A, Minch E, Lum PY, Sachs JR, Schadt EE. Increasing the power to detect causal associations by combining genotypic and expression data in segregating populations. Plos Computational Biology. 3: e69. PMID 17432931 DOI: 10.1371/Journal.Pcbi.0030069  1
2007 Meng H, Vera I, Che N, Wang X, Wang SS, Ingram-Drake L, Schadt EE, Drake TA, Lusis AJ. Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics. Proceedings of the National Academy of Sciences of the United States of America. 104: 4530-5. PMID 17360558 DOI: 10.1073/Pnas.0607620104  1
2007 Itoh Y, Melamed E, Yang X, Kampf K, Wang S, Yehya N, Van Nas A, Replogle K, Band MR, Clayton DF, Schadt EE, Lusis AJ, Arnold AP. Dosage compensation is less effective in birds than in mammals. Journal of Biology. 6: 2. PMID 17352797 DOI: 10.1186/Jbiol53  1
2007 Hovatta I, Zapala MA, Broide RS, Schadt EE, Libiger O, Schork NJ, Lockhart DJ, Barlow C. DNA variation and brain region-specific expression profiles exhibit different relationships between inbred mouse strains: implications for eQTL mapping studies. Genome Biology. 8: R25. PMID 17324278 DOI: 10.1186/Gb-2007-8-2-R25  1
2007 Grupe A, Abraham R, Li Y, Rowland C, Hollingworth P, Morgan A, Jehu L, Segurado R, Stone D, Schadt E, Karnoub M, Nowotny P, Tacey K, Catanese J, Sninsky J, et al. Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants. Human Molecular Genetics. 16: 865-73. PMID 17317784 DOI: 10.1093/Hmg/Ddm031  1
2007 Schadt EE. Embracing the complexity of common human diseases through technology integration Nature Reviews Genetics. 8. DOI: 10.1038/Nrg2241  0.01
2006 Schadt EE, Lum PY. Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Reverse engineering gene networks to identify key drivers of complex disease phenotypes. Journal of Lipid Research. 47: 2601-2613. PMID 17012750 DOI: 10.1194/Jlr.R600026-Jlr200  1
2006 GuhaThakurta D, Xie T, Anand M, Edwards SW, Li G, Wang SS, Schadt EE. Cis-regulatory variations: a study of SNPs around genes showing cis-linkage in segregating mouse populations. Bmc Genomics. 7: 235. PMID 16978413 DOI: 10.1186/1471-2164-7-235  1
2006 Ghazalpour A, Doss S, Zhang B, Wang S, Plaisier C, Castellanos R, Brozell A, Schadt EE, Drake TA, Lusis AJ, Horvath S. Integrating genetic and network analysis to characterize genes related to mouse weight. Plos Genetics. 2: e130. PMID 16934000 DOI: 10.1371/Journal.Pgen.0020130  1
2006 Schadt EE. Novel integrative genomics strategies to identify genes for complex traits Animal Genetics. 37: 18-23. PMID 16886998 DOI: 10.1111/J.1365-2052.2006.01473.X  0.01
2006 Yang X, Schadt EE, Wang S, Wang H, Arnold AP, Ingram-Drake L, Drake TA, Lusis AJ. Tissue-specific expression and regulation of sexually dimorphic genes in mice. Genome Research. 16: 995-1004. PMID 16825664 DOI: 10.1101/Gr.5217506  1
2006 Drake TA, Schadt EE, Lusis AJ. Integrating genetic and gene expression data: Application to cardiovascular and metabolic traits in mice Mammalian Genome. 17: 466-479. PMID 16783628 DOI: 10.1007/S00335-005-0175-Z  1
2006 Lum PY, Chen Y, Zhu J, Lamb J, Melmed S, Wang S, Drake TA, Lusis AJ, Schadt EE. Elucidating the murine brain transcriptional network in a segregating mouse population to identify core functional modules for obesity and diabetes. Journal of Neurochemistry. 97: 50-62. PMID 16635250 DOI: 10.1111/J.1471-4159.2006.03661.X  1
2006 Wang S, Yehya N, Schadt EE, Wang H, Drake TA, Lusis AJ. Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity Plos Genetics. 2. PMID 16462940 DOI: 10.1371/Journal.Pgen.0020015  1
2005 Simon JS, Karnoub MC, Devlin DJ, Arreaza MG, Qiu P, Monks SA, Severino ME, Deutsch P, Palmisano J, Sachs AB, Bayne ML, Plump AS, Schadt EE. Sequence variation in NPC1L1 and association with improved LDL-cholesterol lowering in response to ezetimibe treatment. Genomics. 86: 648-56. PMID 16297596 DOI: 10.1016/J.Ygeno.2005.08.007  1
2005 Drake TA, Schadt EE, Davis RC, Lusis AJ. Integrating genetic and gene expression data to study the metabolic syndrome and diabetes in mice. American Journal of Therapeutics. 12: 503-11. PMID 16280644 DOI: 10.1097/01.Mjt.0000178775.39149.64  1
2005 Schadt EE. Exploiting naturally occurring DNA variation and molecular profiling data to dissect disease and drug response traits. Current Opinion in Biotechnology. 16: 647-654. PMID 16249078 DOI: 10.1016/J.Copbio.2005.10.005  0.01
2005 Hovatta I, Tennant RS, Helton R, Marr RA, Singer O, Redwine JM, Ellison JA, Schadt EE, Verma IM, Lockhart DJ, Barlow C. Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice. Nature. 438: 662-6. PMID 16244648 DOI: 10.1038/Nature04250  1
2005 Mehrabian M, Allayee H, Stockton J, Lum PY, Drake TA, Castellani LW, Suh M, Armour C, Edwards S, Lamb J, Lusis AJ, Schadt EE. Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits. Nature Genetics. 37: 1224-33. PMID 16200066 DOI: 10.1038/Ng1619  1
2005 Cervino AC, Li G, Edwards S, Zhu J, Laurie C, Tokiwa G, Lum PY, Wang S, Castellani LW, Castellini LW, Lusis AJ, Carlson S, Sachs AB, Schadt EE. Integrating QTL and high-density SNP analyses in mice to identify Insig2 as a susceptibility gene for plasma cholesterol levels. Genomics. 86: 505-17. PMID 16126366 DOI: 10.1016/J.Ygeno.2005.07.010  1
2005 Schadt EE, Sachs A, Friend S. Embracing complexity, inching closer to reality. Science's Stke : Signal Transduction Knowledge Environment. 2005: pe40. PMID 16077086 DOI: 10.1126/Stke.2952005Pe40  1
2005 Davis RC, Schadt EE, Smith DJ, Hsieh EW, Cervino AC, van Nas A, Rosales M, Doss S, Meng H, Allayee H, Lusis AJ. A genome-wide set of congenic mouse strains derived from DBA/2J on a C57BL/6J background. Genomics. 86: 259-70. PMID 16039824 DOI: 10.1016/j.ygeno.2005.05.010  1
2005 Ghazalpour A, Doss S, Sheth SS, Ingram-Drake LA, Schadt EE, Lusis AJ, Drake TA. Genomic analysis of metabolic pathway gene expression in mice. Genome Biology. 6: R59. PMID 15998448 DOI: 10.1186/Gb-2005-6-7-R59  1
2005 Schadt EE, Lamb J, Yang X, Zhu J, Edwards S, Guhathakurta D, Sieberts SK, Monks S, Reitman M, Zhang C, Lum PY, Leonardson A, Thieringer R, Metzger JM, Yang L, et al. An integrative genomics approach to infer causal associations between gene expression and disease. Nature Genetics. 37: 710-7. PMID 15965475 DOI: 10.1038/Ng1589  1
2005 Doss S, Schadt EE, Drake TA, Lusis AJ. Cis-acting expression quantitative trait loci in mice. Genome Research. 15: 681-91. PMID 15837804 DOI: 10.1101/Gr.3216905  1
2005 Davis RC, Schadt EE, Cervino AC, Péterfy M, Lusis AJ. Ultrafine mapping of SNPs from mouse strains C57BL/6J, DBA/2J, and C57BLKS/J for loci contributing to diabetes and atherosclerosis susceptibility. Diabetes. 54: 1191-9. PMID 15793261 DOI: 10.2337/Diabetes.54.4.1191  1
2005 Johnson JM, Edwards S, Shoemaker D, Schadt EE. Dark matter in the genome: evidence of widespread transcription detected by microarray tiling experiments. Trends in Genetics. 21: 93-102. PMID 15661355 DOI: 10.1016/J.Tig.2004.12.009  1
2005 Zhu J, Wiener MC, Zhang C, Fridman A, Minch E, Lum PY, Sachs JR, Schadt EE. Increasing the Power to Detect Causal Associations among Genes and between Genes and Complex Traits by Combining Genotypic and Gene Expression Data in Segregating Populations Plos Computational Biology. DOI: 10.1371/Journal.Pcbi.0030069.Eor  1
2004 Monks SA, Leonardson A, Zhu H, Cundiff P, Pietrusiak P, Edwards S, Phillips JW, Sachs A, Schadt EE. Genetic inheritance of gene expression in human cell lines. American Journal of Human Genetics. 75: 1094-105. PMID 15514893 DOI: 10.1086/426461  1
2004 Churchill GA, Airey DC, Allayee H, Angel JM, Attie AD, Beatty J, Beavis WD, Belknap JK, Bennett B, Berrettini W, Bleich A, Bogue M, Broman KW, Buck KJ, Buckler E, ... ... Schadt EE, et al. The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nature Genetics. 36: 1133-7. PMID 15514660 DOI: 10.1038/Ng1104-1133  1
2004 Schadt EE, Edwards SW, GuhaThakurta D, Holder D, Ying L, Svetnik V, Leonardson A, Hart KW, Russell A, Li G, Cavet G, Castle J, McDonagh P, Kan Z, Chen R, et al. A comprehensive transcript index of the human genome generated using microarrays and computational approaches. Genome Biology. 5: R73. PMID 15461792 DOI: 10.1186/Gb-2004-5-10-R73  1
2004 Zhu J, Lum PY, Lamb J, GuhaThakurta D, Edwards SW, Thieringer R, Berger JP, Wu MS, Thompson J, Sachs AB, Schadt EE. An integrative genomics approach to the reconstruction of gene networks in segregating populations. Cytogenetic and Genome Research. 105: 363-74. PMID 15237224 DOI: 10.1159/000078209  1
2003 Johnson JM, Castle J, Garrett-Engele P, Kan Z, Loerch PM, Armour CD, Santos R, Schadt EE, Stoughton R, Shoemaker DD. Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays. Science (New York, N.Y.). 302: 2141-4. PMID 14684825 DOI: 10.1126/Science.1090100  1
2003 Castle J, Garrett-Engele P, Armour CD, Duenwald SJ, Loerch PM, Meyer MR, Schadt EE, Stoughton R, Parrish ML, Shoemaker DD, Johnson JM. Optimization of oligonucleotide arrays and RNA amplification protocols for analysis of transcript structure and alternative splicing. Genome Biology. 4: R66. PMID 14519201 DOI: 10.1186/Gb-2003-4-10-R66  1
2003 Colinayo VV, Qiao JH, Wang X, Krass KL, Schadt E, Lusis AJ, Drake TA. Genetic loci for diet-induced atherosclerotic lesions and plasma lipids in mice. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 14: 464-71. PMID 12925895 DOI: 10.1007/S00335-002-2187-2  1
2003 He YD, Dai H, Schadt EE, Cavet G, Edwards SW, Stepaniants SB, Duenwald S, Kleinhanz R, Jones AR, Shoemaker DD, Stoughton RB. Microarray standard data set and figures of merit for comparing data processing methods and experiment designs. Bioinformatics. 19: 956-965. PMID 12761058 DOI: 10.1093/Bioinformatics/Btg126  1
2003 Kraft P, Schadt E, Aten J, Horvath S. A family-based test for correlation between gene expression and trait values. American Journal of Human Genetics. 72: 1323-30. PMID 12687497 DOI: 10.1086/375167  1
2003 Schadt EE, Monks SA, Friend SH. A new paradigm for drug discovery: integrating clinical, genetic, genomic and molecular phenotype data to identify drug targets. Biochemical Society Transactions. 31: 437-443. PMID 12653656 DOI: 10.1042/Bst0310437  1
2003 Schadt EE, Monks SA, Drake TA, Lusis AJ, Che N, Colinayo V, Ruff TG, Milligan SB, Lamb JR, Cavet G, Linsley PS, Mao M, Stoughton RB, Friend SH. Genetics of gene expression surveyed in maize, mouse and man Nature. 422: 297-302. PMID 12646919 DOI: 10.1038/Nature01434  1
2002 Schadt EE, Sinsheimer JS, Lange K. Applications of codon and rate variation models in molecular phylogeny. Molecular Biology and Evolution. 19: 1550-62. PMID 12200482 DOI: 10.1093/Oxfordjournals.Molbev.A004217  1
2002 Schadt E, Lange K. Codon and Rate Variation Models in Molecular Phylogeny Molecular Biology and Evolution. 19: 1534-1549. PMID 12200481 DOI: 10.1093/Oxfordjournals.Molbev.A004216  1
2002 Lock C, Hermans G, Pedotti R, Brendolan A, Schadt E, Garren H, Langer-Gould A, Strober S, Cannella B, Allard J, Klonowski P, Austin A, Lad N, Kaminski N, Galli SJ, et al. Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nature Medicine. 8: 500-8. PMID 11984595 DOI: 10.1038/Nm0502-500  1
2001 Waring JF, Jolly RA, Ciurlionis R, Lum PY, Praestgaard JT, Morfitt DC, Buratto B, Roberts C, Schadt E, Ulrich RG. Clustering of hepatotoxins based on mechanism of toxicity using gene expression profiles. Toxicology and Applied Pharmacology. 175: 28-42. PMID 11509024 DOI: 10.1006/Taap.2001.9243  1
2001 Shoemaker DD, Schadt EE, Armour CD, He YD, Garrett-Engele P, McDonagh PD, Loerch PM, Leonardson A, Lum PY, Cavet G, Wu LF, Altschuler SJ, Edwards S, King J, Tsang JS, et al. Experimental annotation of the human genome using microarray technology. Nature. 409: 922-7. PMID 11237012 DOI: 10.1038/35057141  1
2001 Schadt EE. The making of a bioinformatician Journal of Cellular Biochemistry. 80: 212-215. PMID 11074591 DOI: 10.1002/1097-4644(20010201)80:2<212::Aid-Jcb90>3.0.Co;2-E  0.01
2001 Schadt EE, Li C, Su C, Wong WH. Analyzing high-density oligonucleotide gene expression array data. Journal of Cellular Biochemistry. 80: 192-202. PMID 11074587 DOI: 10.1002/1097-4644(20010201)80:2<192::Aid-Jcb50>3.0.Co;2-W  0.01
2000 Ewart SL, Kuperman D, Schadt E, Tankersley C, Grupe A, Shubitowski DM, Peltz G, Wills-Karp M. Quantitative trait loci controlling allergen-induced airway hyperresponsiveness in inbred mice American Journal of Respiratory Cell and Molecular Biology. 23: 537-545. PMID 11017920 DOI: 10.1165/Ajrcmb.23.4.4199  1
2000 Karp CL, Grupe A, Schadt E, Ewart SL, Keane-Moore M, Cuomo PJ, Köhl J, Wahl L, Kuperman D, Germer S, Aud D, Peltz G, Wills-Karp M. Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma. Nature Immunology. 1: 221-6. PMID 10973279 DOI: 10.1038/79759  1
1998 Schadt EE, Sinsheimer JS, Lange K. Computational advances in maximum likelihood methods for molecular phylogeny Genome Research. 8: 222-233. PMID 9521926 DOI: 10.1101/Gr.8.3.222  1
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