Paul D. Piehowski, Ph.D. - Publications

Pennsylvania State University, State College, PA, United States 
Bioanalytical Chemistry

57 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Sigdel TK, Piehowski PD, Roy S, Liberto J, Hansen JR, Swensen AC, Zhao R, Zhu Y, Rashmi P, Schroeder A, Damm I, Sur S, Luo J, Yang Y, Qian WJ, et al. Near-Single-Cell Proteomics Profiling of the Proximal Tubular and Glomerulus of the Normal Human Kidney. Frontiers in Medicine. 7: 499. PMID 33072769 DOI: 10.3389/fmed.2020.00499  1
2020 Bramer LM, Irvahn J, Piehowski PD, Rodland KD, Webb-Robertson BM. A review of imputation strategies for isobaric labeling-based shotgun proteomics. Journal of Proteome Research. PMID 32929967 DOI: 10.1021/acs.jproteome.0c00123  0.44
2020 Alcazar O, Hernandez LF, Nakayasu ES, Piehowski PD, Ansong C, Abdulreda MH, Buchwald P. Longitudinal proteomics analysis in the immediate microenvironment of islet allografts during progression of rejection. Journal of Proteomics. 103826. PMID 32442648 DOI: 10.1016/j.jprot.2020.103826  0.48
2020 Zhang T, Gaffrey MJ, Monroe ME, Thomas DG, Weitz KK, Piehowski PD, Petyuk VA, Moore RJ, Thrall BD, Qian WJ. Block design with common reference samples enables robust large-scale label-free quantitative proteome profiling. Journal of Proteome Research. PMID 32407631 DOI: 10.1021/acs.jproteome.0c00310  1
2020 Wang X, Swensen AC, Zhang T, Piehowski PD, Gaffrey MJ, Monroe ME, Zhu Y, Dong H, Qian WJ. Accurate Identification of Deamidation and Citrullination from Global Shotgun Proteomics Data Using a Dual-search Delta Score Strategy. Journal of Proteome Research. PMID 32175737 DOI: 10.1021/acs.jproteome.9b00766  1
2020 Zhang T, Gaffrey MJ, Thomas DG, Weber TJ, Hess BM, Weitz KK, Piehowski PD, Petyuk VA, Moore RJ, Qian WJ, Thrall BD. A proteome-wide assessment of the oxidative stress paradigm for metal and metal-oxide nanomaterials in human macrophages. Nanoimpact. 17. PMID 32133426 DOI: 10.1016/j.impact.2019.100194  1
2020 Piehowski PD, Zhu Y, Bramer LM, Stratton KG, Zhao R, Orton DJ, Moore RJ, Yuan J, Mitchell HD, Gao Y, Webb-Robertson BM, Dey SK, Kelly RT, Burnum-Johnson KE. Automated mass spectrometry imaging of over 2000 proteins from tissue sections at 100-μm spatial resolution. Nature Communications. 11: 8. PMID 31911630 DOI: 10.1038/s41467-019-13858-z  1
2019 Arshad OA, Danna V, Petyuk VA, Piehowski PD, Liu T, Rodland KD, McDermott JE. An Integrative Analysis of Tumor Proteomic and Phosphoproteomic Profiles to Examine the Relationships Between Kinase Activity and Phosphorylation. Molecular & Cellular Proteomics : McP. 18: S26-S36. PMID 33451495 DOI: 10.1074/mcp.RA119.001540  0.52
2019 Johnston GP, Bradel-Tretheway B, Piehowski PD, Brewer HM, Lee BNR, Usher NT, Zamora JLR, Ortega V, Contreras EM, Teuton JR, Wendler JP, Matz KM, Adkins JN, Aguilar HC. Nipah Virus-Like Particle Egress Is Modulated by Cytoskeletal and Vesicular Trafficking Pathways: a Validated Particle Proteomics Analysis. Msystems. 4. PMID 31551400 DOI: 10.1128/mSystems.00194-19  0.48
2019 Nagarajan A, Zhou M, Nguyen AY, Liberton M, Kedia K, Shi T, Piehowski P, Shukla A, Fillmore TL, Nicora C, Smith RD, Koppenaal DW, Jacobs JM, Pakrasi HB. Proteomic Insights into Phycobilisome Degradation, A Selective and Tightly Controlled Process in The Fast-Growing Cyanobacterium UTEX 2973. Biomolecules. 9. PMID 31426316 DOI: 10.3390/biom9080374  1
2019 Dirice E, Kahraman S, De Jesus DF, El Ouaamari A, Basile G, Baker RL, Yigit B, Piehowski PD, Kim MJ, Dwyer AJ, Ng RWS, Schuster C, Vethe H, Martinov T, Ishikawa Y, et al. Increased β-cell proliferation before immune cell invasion prevents progression of type 1 diabetes. Nature Metabolism. 1: 509-518. PMID 31423480 DOI: 10.1038/s42255-019-0061-8  1
2019 Dou M, Tsai CF, Piehowski PD, Wang Y, Fillmore TL, Zhao R, Moore RJ, Zhang P, Qian WJ, Smith RD, Liu T, Kelly RT, Shi T, Zhu Y. Automated Nanoflow Two-Dimensional Reversed-Phase Liquid Chromatography System Enables In-Depth Proteome and Phosphoproteome Profiling of Nanoscale Samples. Analytical Chemistry. PMID 31241912 DOI: 10.1021/acs.analchem.9b01248  1
2019 Arshad OA, Danna V, Petyuk VA, Piehowski PD, Liu T, Rodland K, McDermott JE. An integrative analysis of tumor proteomic and phosphoproteomic profiles to examine the relationships between kinase activity and phosphorylation. Molecular & Cellular Proteomics : McP. PMID 31227600 DOI: 10.1074/mcp.RA119.001540  0.52
2019 Yi L, Tsai CF, Dirice E, Swensen AC, Chen J, Shi T, Gritsenko MA, Chu RK, Piehowski PD, Smith RD, Rodland KD, Atkinson MA, Mathews CE, Kulkarni RN, Liu T, et al. A Boosting to Amplify Signal with Isobaric Labeling (BASIL) Strategy for Comprehensive Quantitative Phosphoproteomic Characterization of Small Populations of Cells. Analytical Chemistry. PMID 30843680 DOI: 10.1021/acs.analchem.9b00024  1
2019 Wakasaki R, Matsushita K, Golgotiu K, Anderson S, Eiwaz MB, Orton DJ, Han SJ, Lee HT, Smith RD, Rodland KD, Piehowski PD, Hutchens MP. Glomerular filtrate proteins in acute cardiorenal syndrome. Jci Insight. 4. PMID 30829647 DOI: 10.1172/jci.insight.122130  1
2018 Couvillion SP, Zhu Y, Nagy G, Adkins JN, Ansong C, Renslow RS, Piehowski PD, Ibrahim YM, Kelly RT, Metz TO. New mass spectrometry technologies contributing towards comprehensive and high throughput omics analyses of single cells. The Analyst. PMID 30507980 DOI: 10.1039/c8an01574k  0.48
2018 Xu K, Liang Y, Piehowski PD, Dou M, Schwarz KC, Zhao R, Sontag RL, Moore RJ, Zhu Y, Kelly RT. Benchtop-compatible sample processing workflow for proteome profiling of < 100 mammalian cells. Analytical and Bioanalytical Chemistry. PMID 30460388 DOI: 10.1007/s00216-018-1493-9  1
2018 Zhu Y, Piehowski PD, Kelly RT, Qian WJ. Nanoproteomics comes of age. Expert Review of Proteomics. 1-7. PMID 30375896 DOI: 10.1080/14789450.2018.1537787  1
2018 Matsushita K, Golgotiu K, Orton DJ, Smith RD, Rodland KD, Piehowski PD, Hutchens MP. Micropuncture of Bowman's Space in Mice Facilitated by 2 Photon Microscopy. Journal of Visualized Experiments : Jove. PMID 30371667 DOI: 10.3791/58206  1
2018 Dou M, Zhu Y, Liyu A, Liang Y, Chen J, Piehowski PD, Xu K, Zhao R, Moore RJ, Atkinson MA, Mathews CE, Qian WJ, Kelly RT. Nanowell-mediated two-dimensional liquid chromatography enables deep proteome profiling of <1000 mammalian cells. Chemical Science. 9: 6944-6951. PMID 30210768 DOI: 10.1039/c8sc02680g  1
2018 Kedia K, Wendler JP, Baker ES, Burnum-Johnson KE, Jarsberg LG, Stratton KG, Wright AT, Piehowski PD, Gritsenko MA, Lewinsohn DM, Sigal GB, Weiner MH, Smith RD, Jacobs JM, Nahid P. Application of multiplexed ion mobility spectrometry towards the identification of host protein signatures of treatment effect in pulmonary tuberculosis. Tuberculosis (Edinburgh, Scotland). 112: 52-61. PMID 30205969 DOI: 10.1016/  1
2018 Petyuk VA, Chang R, Ramirez-Restrepo M, Beckmann ND, Henrion MYR, Piehowski PD, Zhu K, Wang S, Clarke J, Huentelman MJ, Xie F, Andreev V, Engel A, Guettoche T, Navarro L, et al. The human brainome: network analysis identifies HSPA2 as a novel Alzheimer's disease target. Brain : a Journal of Neurology. PMID 30137212 DOI: 10.1093/brain/awy215  1
2018 Zhu Y, Dou M, Piehowski PD, Liang Y, Wang F, Chu RK, Chrisler W, Smith JN, Schwarz KC, Shen Y, Shukla AK, Moore RJ, Smith RD, Qian WJ, Kelly RT. Spatially resolved proteome mapping of laser capture microdissected tissue with automated sample transfer to nanodroplets. Molecular & Cellular Proteomics : McP. PMID 29941660 DOI: 10.1074/mcp.TIR118.000686  1
2018 Yu L, Petyuk VA, Gaiteri C, Mostafavi S, Young-Pearse T, Shah RC, Buchman AS, Schneider JA, Piehowski PD, Sontag RL, Fillmore TL, Shi T, Smith RD, De Jager PL, Bennett DA. Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia. Annals of Neurology. PMID 29908079 DOI: 10.1002/ana.25266  1
2018 Park J, Piehowski PD, Wilkins C, Zhou M, Mendoza J, Fujimoto GM, Gibbons BC, Shaw JB, Shen Y, Shukla AK, Moore RJ, Liu T, Petyuk VA, Tolić N, Paša-Tolić L, et al. Author Correction: Informed-Proteomics: open-source software package for top-down proteomics. Nature Methods. PMID 29899368 DOI: 10.1038/s41592-018-0040-0  1
2018 Rodland KD, Piehowski P, Smith RD. Moonshot Objectives: Catalyze New Scientific Breakthroughs-Proteogenomics. Cancer Journal (Sudbury, Mass.). 24: 117-121. PMID 29794536 DOI: 10.1097/PPO.0000000000000315  1
2018 Stanfill BA, Nakayasu ES, Bramer LM, Thompson AM, Ansong CK, Clauss T, Gritsenko MA, Monroe ME, Moore RJ, Orton DJ, Piehowski PD, Schepmoes AA, Smith RD, Webb-Robertson BJ, Metz TO, et al. QC-ART: A tool for real-time quality control assessment of mass spectrometry-based proteomics data. Molecular & Cellular Proteomics : McP. PMID 29666158 DOI: 10.1074/mcp.RA118.000648  1
2018 Zhu Y, Zhao R, Piehowski PD, Moore RJ, Lim S, Orphan VJ, Paša-Tolić L, Qian WJ, Smith RD, Kelly RT. Subnanogram proteomics: impact of LC column selection, MS instrumentation and data analysis strategy on proteome coverage for trace samples. International Journal of Mass Spectrometry. 427: 4-10. PMID 29576737 DOI: 10.1016/j.ijms.2017.08.016  1
2018 Zhu Y, Piehowski PD, Zhao R, Chen J, Shen Y, Moore RJ, Shukla AK, Petyuk VA, Campbell-Thompson M, Mathews CE, Smith RD, Qian WJ, Kelly RT. Nanodroplet processing platform for deep and quantitative proteome profiling of 10-100 mammalian cells. Nature Communications. 9: 882. PMID 29491378 DOI: 10.1038/s41467-018-03367-w  1
2018 Orwoll ES, Wiedrick J, Jacobs J, Baker ES, Piehowski P, Petyuk V, Gao Y, Shi T, Smith RD, Bauer DC, Cummings SR, Nielson CM, Lapidus J. High-throughput serum proteomics for the identification of protein biomarkers of mortality in older men. Aging Cell. PMID 29399943 DOI: 10.1111/acel.12717  1
2017 Smith JN, Tyrrell KJ, Hansen JR, Thomas DG, Murphree TA, Shukla AK, Luders T, Madden JM, Li Y, Wright AT, Piehowski PD. Plasma Protein Turnover Rates in Rats Using Stable Isotope Labeling, Global Proteomics, and Activity-Based Protein Profiling. Analytical Chemistry. PMID 29164873 DOI: 10.1021/acs.analchem.7b03984  1
2017 Piehowski PD, Zhao R, Moore RJ, Clair G, Ansong C. Quantitative Proteomic Analysis of Mass Limited Tissue Samples for Spatially Resolved Tissue Profiling. Methods in Molecular Biology (Clifton, N.J.). PMID 28980276 DOI: 10.1007/7651_2017_78  1
2017 Park J, Piehowski PD, Wilkins C, Zhou M, Mendoza J, Fujimoto GM, Gibbons BC, Shaw JB, Shen Y, Shukla AK, Moore RJ, Liu T, Petyuk VA, Tolić N, Paša-Tolić L, et al. Informed-Proteomics: open-source software package for top-down proteomics. Nature Methods. PMID 28783154 DOI: 10.1038/nmeth.4388  1
2017 Yi L, Piehowski PD, Shi T, Smith RD, Qian WJ. Advances in microscale separations towards nanoproteomics applications. Journal of Chromatography. A. PMID 28765000 DOI: 10.1016/j.chroma.2017.07.055  1
2017 Nielson CM, Wiedrick J, Shen J, Jacobs J, Baker ES, Baraff A, Piehowski P, Lee CG, Baratt A, Petyuk V, McWeeney S, Lim JY, Bauer DC, Lane NE, Cawthon PM, et al. Identification of Hip BMD Loss and Fracture Risk Markers through Population-based Serum Proteomics. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 28316103 DOI: 10.1002/jbmr.3125  1
2017 Shen Y, Tolić N, Piehowski PD, Shukla AK, Kim S, Zhao R, Qu Y, Robinson E, Smith RD, Paša-Tolić L. High-resolution ultrahigh-pressure long column reversed-phase liquid chromatography for top-down proteomics. Journal of Chromatography. A. PMID 28077236 DOI: 10.1016/j.chroma.2017.01.008  1
2016 Clair G, Piehowski PD, Nicola T, Kitzmiller JA, Huang EL, Zink EM, Sontag RL, Orton DJ, Moore RJ, Carson JP, Smith RD, Whitsett JA, Corley RA, Ambalavanan N, Ansong C. Spatially-Resolved Proteomics: Rapid Quantitative Analysis of Laser Capture Microdissected Alveolar Tissue Samples. Scientific Reports. 6: 39223. PMID 28004771 DOI: 10.1038/srep39223  1
2016 Hasin-Brumshtein Y, Khan AH, Hormozdiari F, Pan C, Parks BW, Petyuk VA, Piehowski PD, Bruemmer A, Pellegrini M, Xiao X, Eskin E, Smith RD, Lusis AJ, Smith DJ. Hypothalamic transcriptomes of 99 mouse strains reveal trans eQTL hotspots, splicing QTLs and novel non-coding genes. Elife. 5. PMID 27623010 DOI: 10.7554/eLife.15614  1
2016 Huang EL, Piehowski PD, Orton DJ, Moore RJ, Qian WJ, Casey CP, Sun X, Dey SK, Burnum-Johnson KE, Smith RD. SNaPP: Simplified Nano-Proteomics Platform for reproducible global proteomic analysis of nanogram protein quantities. Endocrinology. en20151821. PMID 26745641 DOI: 10.1210/en.2015-1821  1
2015 Aylward FO, Khadempour L, Tremmel DM, McDonald BR, Nicora CD, Wu S, Moore RJ, Orton DJ, Monroe ME, Piehowski PD, Purvine SO, Smith RD, Lipton MS, Burnum-Johnson KE, Currie CR. Correction: Enrichment and Broad Representation of Plant Biomass-Degrading Enzymes in the Specialized Hyphal Swellings of Leucoagaricus gongylophorus, the Fungal Symbiont of Leaf-Cutter Ants. Plos One. 10: e0139151. PMID 26398520 DOI: 10.1371/journal.pone.0139151  1
2015 Aylward FO, Khadempour L, Tremmel DM, McDonald BR, Nicora CD, Wu S, Moore RJ, Orton DJ, Monroe ME, Piehowski PD, Purvine SO, Smith RD, Lipton MS, Burnum-Johnson KE, Currie CR. Enrichment and Broad Representation of Plant Biomass-Degrading Enzymes in the Specialized Hyphal Swellings of Leucoagaricus gongylophorus, the Fungal Symbiont of Leaf-Cutter Ants. Plos One. 10: e0134752. PMID 26317212 DOI: 10.1371/journal.pone.0134752  1
2015 Cha J, Burnum-Johnson KE, Bartos A, Li Y, Baker ES, Tilton SC, Webb-Robertson BJ, Piehowski PD, Monroe ME, Jegga AG, Murata S, Hirota Y, Dey SK. Muscle Segment Homeobox Genes Direct Embryonic Diapause by Limiting Inflammation in the Uterus. The Journal of Biological Chemistry. 290: 15337-49. PMID 25931120 DOI: 10.1074/jbc.M115.655001  1
2015 Wright AT, Magnaldo T, Sontag RL, Anderson LN, Sadler NC, Piehowski PD, Gache Y, Weber TJ. Deficient expression of aldehyde dehydrogenase 1A1 is consistent with increased sensitivity of Gorlin syndrome patients to radiation carcinogenesis. Molecular Carcinogenesis. 54: 473-84. PMID 24285572 DOI: 10.1002/mc.22115  1
2014 Hyung SW, Piehowski PD, Moore RJ, Orton DJ, Schepmoes AA, Clauss TR, Chu RK, Fillmore TL, Brewer H, Liu T, Zhao R, Smith RD. Microscale depletion of high abundance proteins in human biofluids using IgY14 immunoaffinity resin: analysis of human plasma and cerebrospinal fluid. Analytical and Bioanalytical Chemistry. 406: 7117-25. PMID 25192788 DOI: 10.1007/s00216-014-8058-3  1
2014 Baker ES, Burnum-Johnson KE, Jacobs JM, Diamond DL, Brown RN, Ibrahim YM, Orton DJ, Piehowski PD, Purdy DE, Moore RJ, Danielson WF, Monroe ME, Crowell KL, Slysz GW, Gritsenko MA, et al. Advancing the high throughput identification of liver fibrosis protein signatures using multiplexed ion mobility spectrometry. Molecular & Cellular Proteomics : McP. 13: 1119-27. PMID 24403597 DOI: 10.1074/mcp.M113.034595  1
2013 Crowell KL, Baker ES, Payne SH, Ibrahim YM, Monroe ME, Slysz GW, LaMarche BL, Petyuk VA, Piehowski PD, Danielson WF, Anderson GA, Smith RD. Increasing Confidence of LC-MS Identifications by Utilizing Ion Mobility Spectrometry. International Journal of Mass Spectrometry. 354: 312-317. PMID 25089116 DOI: 10.1016/j.ijms.2013.06.028  1
2013 Aylward FO, Burnum-Johnson KE, Tringe SG, Teiling C, Tremmel DM, Moeller JA, Scott JJ, Barry KW, Piehowski PD, Nicora CD, Malfatti SA, Monroe ME, Purvine SO, Goodwin LA, Smith RD, et al. Leucoagaricus gongylophorus produces diverse enzymes for the degradation of recalcitrant plant polymers in leaf-cutter ant fungus gardens. Applied and Environmental Microbiology. 79: 3770-8. PMID 23584789 DOI: 10.1128/AEM.03833-12  1
2013 Piehowski PD, Petyuk VA, Orton DJ, Xie F, Moore RJ, Ramirez-Restrepo M, Engel A, Lieberman AP, Albin RL, Camp DG, Smith RD, Myers AJ. Sources of technical variability in quantitative LC-MS proteomics: human brain tissue sample analysis. Journal of Proteome Research. 12: 2128-37. PMID 23495885 DOI: 10.1021/pr301146m  1
2013 Piehowski PD, Petyuk VA, Sandoval JD, Burnum KE, Kiebel GR, Monroe ME, Anderson GA, Camp DG, Smith RD. STEPS: a grid search methodology for optimized peptide identification filtering of MS/MS database search results. Proteomics. 13: 766-70. PMID 23303698 DOI: 10.1002/pmic.201200096  1
2012 Aylward FO, Burnum KE, Scott JJ, Suen G, Tringe SG, Adams SM, Barry KW, Nicora CD, Piehowski PD, Purvine SO, Starrett GJ, Goodwin LA, Smith RD, Lipton MS, Currie CR. Metagenomic and metaproteomic insights into bacterial communities in leaf-cutter ant fungus gardens. The Isme Journal. 6: 1688-701. PMID 22378535 DOI: 10.1038/ismej.2012.10  1
2010 Heien ML, Piehowski PD, Winograd N, Ewing AG. Lipid detection, identification, and imaging single cells with SIMS. Methods in Molecular Biology (Clifton, N.J.). 656: 85-97. PMID 20680585 DOI: 10.1007/978-1-60761-746-4_4  0.6
2010 Kurczy ME, Piehowski PD, Van Bell CT, Heien ML, Winograd N, Ewing AG. Mass spectrometry imaging of mating Tetrahymena show that changes in cell morphology regulate lipid domain formation. Proceedings of the National Academy of Sciences of the United States of America. 107: 2751-6. PMID 20133641 DOI: 10.1073/pnas.0908101107  1
2009 Piehowski PD, Davey AM, Kurczy ME, Sheets ED, Winograd N, Ewing AG, Heien ML. Time-of-flight secondary ion mass spectrometry imaging of subcellular lipid heterogeneity: Poisson counting and spatial resolution. Analytical Chemistry. 81: 5593-602. PMID 19530687 DOI: 10.1021/ac901065s  0.6
2008 Kurczy ME, Piehowski PD, Parry SA, Jiang M, Chen G, Ewing AG, Winograd N. Which is more important in bioimaging SIMS experiments-The sample preparation or the nature of the projectile? Applied Surface Science. 255: 1298-1304. PMID 19554199 DOI: 10.1016/j.apsusc.2008.05.139  0.6
2008 Kurczy ME, Kozole J, Parry SA, Piehowski PD, Winograd N, Ewing AG. Relative Quantification of Cellular Sections with Molecular Depth Profiling ToF-SIMS Imaging. Applied Surface Science. 255: 1158-1161. PMID 19247454 DOI: 10.1016/j.apsusc.2008.05.018  0.6
2008 Piehowski PD, Carado AJ, Kurczy ME, Ostrowski SG, Heien ML, Winograd N, Ewing AG. MS/MS methodology to improve subcellular mapping of cholesterol using TOF-SIMS. Analytical Chemistry. 80: 8662-7. PMID 18925746 DOI: 10.1021/ac801591r  0.6
2008 Piehowski PD, Kurczy ME, Willingham D, Parry S, Heien ML, Winograd N, Ewing AG. Freeze-etching and vapor matrix deposition for ToF-SIMS imaging of single cells. Langmuir : the Acs Journal of Surfaces and Colloids. 24: 7906-11. PMID 18570446 DOI: 10.1021/la800292e  0.6
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