werner sieghart - Publications

Medical University Vienna, Wien, Wien, Austria 
GABAA receptors

247 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Sieghart W, Chiou LC, Ernst M, Fabjan J, M Savić M, Lee MT. 6-Containing GABA Receptors: Functional Roles and Therapeutic Potentials. Pharmacological Reviews. 74: 238-270. PMID 35017178 DOI: 10.1124/pharmrev.121.000293  0.448
2021 Belelli D, Hales TG, Lambert JJ, Luscher B, Olsen R, Peters JA, Rudolph U, Sieghart W. GABA receptors in GtoPdb v.2021.3. Iuphar/Bps Guide to Pharmacology Cite. 2021. PMID 35005623 DOI: 10.2218/gtopdb/F72/2021.3  0.439
2021 Golani LK, Platt DM, Rüedi-Bettschen D, Edwanker C, Huang S, Poe MM, Furtmüller R, Sieghart W, Cook JM, Rowlett JK. 8-Substituted Triazolobenzodiazepines: and Pharmacology in Relation to Structural Docking at the α1 Subunit-Containing GABA Receptor. Frontiers in Pharmacology. 12: 625233. PMID 33959005 DOI: 10.3389/fphar.2021.625233  0.346
2020 Tzeng HR, Lee MT, Fan PC, Knutson DE, Lai TH, Sieghart W, Cook J, Chiou LC. α6GABA Receptor Positive Modulators Alleviate Migraine-like Grimaces in Mice via Compensating GABAergic Deficits in Trigeminal Ganglia. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 33111258 DOI: 10.1007/s13311-020-00951-1  0.33
2020 Sperk G, Kirchmair E, Bakker J, Sieghart W, Drexel M, Kondova I. Immunohistochemical distribution of 10 GABA receptor subunits in the forebrain of the rhesus monkey Macaca mulatta. The Journal of Comparative Neurology. PMID 32220012 DOI: 10.1002/cne.24910  0.33
2019 Stefanits H, Milenkovic I, Mahr N, Pataraia E, Baumgartner C, Hainfellner JA, Kovacs GG, Kasprian G, Sieghart W, Yilmazer-Hanke D, Czech T. Alterations in GABAA Receptor Subunit Expression in the Amygdala and Entorhinal Cortex in Human Temporal Lobe Epilepsy. Journal of Neuropathology and Experimental Neurology. 78: 1022-1048. PMID 31631219 DOI: 10.1093/jnen/nlz085  0.411
2019 Kasugai Y, Vogel E, Hörtnagl H, Schönherr S, Paradiso E, Hauschild M, Göbel G, Milenkovic I, Peterschmitt Y, Tasan R, Sperk G, Shigemoto R, Sieghart W, Singewald N, Lüthi A, et al. Structural and Functional Remodeling of Amygdala GABAergic Synapses in Associative Fear Learning. Neuron. PMID 31543297 DOI: 10.1016/j.neuron.2019.08.013  0.38
2019 Vasović D, Divović B, Treven M, Knutson DE, Steudle F, Scholze P, Obradović A, Fabjan J, Brković B, Sieghart W, Ernst M, Cook JM, Savić MM. Trigeminal neuropathic pain development and maintenance in rats are suppressed by a positive modulator of α6 GABA receptors. European Journal of Pain (London, England). PMID 30633839 DOI: 10.1002/Ejp.1365  0.481
2018 Sieghart W, Savić MM. International Union of Basic and Clinical Pharmacology. CVI: GABA Receptor Subtype- and Function-selective Ligands: Key Issues in Translation to Humans. Pharmacological Reviews. 70: 836-878. PMID 30275042 DOI: 10.1124/pr.117.014449  0.537
2018 Fan PC, Lai TH, Hor CC, Lee MT, Huang P, Sieghart W, Ernst M, Knutson DE, Cook J, Chiou LC. The α6 subunit-containing GABA receptor: A novel drug target for inhibition of trigeminal activation. Neuropharmacology. PMID 30016665 DOI: 10.1016/J.Neuropharm.2018.07.017  0.382
2018 Siebert DCB, Bampali K, Puthenkalam R, Varagic Z, Sarto-Jackson I, Scholze P, Sieghart W, Mihovilovic MD, Schnürch M, Ernst M. Engineered flumazenil recognition site provides mechanistic insight governing benzodiazepine modulation in GABA receptors. Acs Chemical Biology. PMID 29989390 DOI: 10.1021/acschembio.8b00145  0.373
2018 Duke AN, Meng Z, Platt DM, Atack JR, Dawson GR, Reynolds DS, Tiruveedhula VVNPB, Li G, Stephen MR, Sieghart W, Cook JM, Rowlett JK. Evidence that Sedative Effects of Benzodiazepines Involve Unexpected GABA Receptor Subtypes: Quantitative Observation Studies in Rhesus Monkeys. The Journal of Pharmacology and Experimental Therapeutics. PMID 29720564 DOI: 10.1124/Jpet.118.249250  0.465
2018 Chiou LC, Lee HJ, Ernst M, Huang WJ, Chou JF, Chen HL, Mouri A, Chen LC, Treven M, Mamiya T, Fan PC, Knutson DE, Witzigmann C, Cook J, Sieghart W, et al. Cerebellar α6 subunit-containing GABAreceptors: A novel therapeutic target for disrupted prepulse inhibition in neuropsychiatric disorders. British Journal of Pharmacology. PMID 29518821 DOI: 10.1111/Bph.14198  0.392
2018 Knutson DE, Kodali R, Divovic B, Treven M, Stephen MR, Zahn NM, Dobričić V, Huber AT, Meirelles MA, Verma RS, Wimmer L, Witzigmann C, Arnold LA, Chiou LC, Ernst M, ... ... Sieghart W, et al. Design and Synthesis of Novel Deuterated Ligands Functionally Selective for the γ-Aminobutyric Acid Type A Receptor (GABAR) α6 Subtype with Improved Metabolic Stability and Enhanced Bioavailability. Journal of Medicinal Chemistry. PMID 29481759 DOI: 10.1021/Acs.Jmedchem.7B01664  0.323
2017 Stefanits H, Milenkovic I, Mahr N, Pataraia E, Hainfellner JA, Kovacs GG, Sieghart W, Yilmazer-Hanke D, Czech T. GABAA receptor subunits in the human amygdala and hippocampus: Immunohistochemical distribution of 7 subunits. The Journal of Comparative Neurology. PMID 29023704 DOI: 10.1002/cne.24337  0.407
2016 Jonas O, Calligaris D, Methuku KR, Poe MM, Francois JP, Tranghese F, Changelian A, Sieghart W, Ernst M, Krummel DA, Cook JM, Pomeroy SL, Cima M, Agar NY, Langer R, et al. First In Vivo Testing of Compounds Targeting Group 3 Medulloblastomas Using an Implantable Microdevice as a New Paradigm for Drug Development. Journal of Biomedical Nanotechnology. 12: 1297-302. PMID 27319222 DOI: 10.1166/Jbn.2016.2262  0.314
2016 Ghafari M, Falsafi SK, Szodorai E, Kim EJ, Li L, Höger H, Berger J, Fuchs K, Sieghart W, Lubec G. Formation of GABAA receptor complexes containing α1 and α5 subunits is paralleling a multiple T-maze learning task in mice. Brain Structure & Function. PMID 27155990 DOI: 10.1007/s00429-016-1233-x  0.348
2016 Hoerbelt P, Ramerstorfer J, Ernst M, Sieghart W, Thomson JL, Hough LB, Fleck MW. Mutagenesis and computational docking studies support the existence of a histamine binding site at the extracellular β3+β3- interface of homooligomeric β3 GABAA receptors. Neuropharmacology. PMID 27140694 DOI: 10.1016/J.Neuropharm.2016.04.042  0.304
2015 Pangratz-Fuehrer S, Sieghart W, Rudolph U, Parada I, Huguenard JR. Early Postnatal Switch in GABAAR α Subunits in the Reticular Thalamic Nucleus. Journal of Neurophysiology. jn.00905.2015. PMID 26631150 DOI: 10.1152/jn.00905.2015  0.363
2015 Stojanovic T, Capo I, Aronica E, Adle-Biassette H, Höger H, Sieghart W, Kovacs GG, Milenkovic I. The α1, α2, α3, and γ2 subunits of GABAA receptors show characteristic spatial and temporal expression patterns in rhombencephalic structures during normal human brain development. The Journal of Comparative Neurology. PMID 26518133 DOI: 10.1002/cne.23923  0.425
2015 Kudryavtsev DS, Shelukhina IV, Son LV, Ojomoko LO, Kryukova EV, Lyukmanova EN, Zhmak MN, Dolgikh DA, Ivanov IA, Kasheverov IE, Starkov VG, Ramerstorfer J, Sieghart W, Tsetlin VI, Utkin YN. Neurotoxins from Snake Venoms and α-Conotoxin ImI Inhibit Functionally Active Ionotropic γ-Aminobutyric Acid (GABA) Receptors. The Journal of Biological Chemistry. 290: 22747-58. PMID 26221036 DOI: 10.1074/jbc.M115.648824  0.417
2015 Sieghart W. Allosteric modulation of GABAA receptors via multiple drug-binding sites. Advances in Pharmacology (San Diego, Calif.). 72: 53-96. PMID 25600367 DOI: 10.1016/bs.apha.2014.10.002  0.46
2015 Ramerstorfer J, Foppa V, Thiery H, Hermange P, Janody S, Berger ML, Dodd RH, Sieghart W. GABA(A) receptor subtype-selectivity of novel bicuculline derivatives. Current Medicinal Chemistry. 22: 771-80. PMID 25386826 DOI: 10.2174/0929867321666141106110356  0.526
2015 Ernst M, Sieghart W. GABAA receptor subtypes: structural variety raises hope for new therapy concepts E-Neuroforum. 21. DOI: 10.1515/s13295-015-0016-9  0.467
2015 Ernst M, Sieghart W. GABAA-Rezeptorsubtypen: Strukturelle Vielfalt gibt Hoffnung auf neue Therapiekonzepte E-Neuroforum. 21. DOI: 10.1515/s12269-015-0025-1  0.44
2015 Ernst M, Sieghart W. GABAA receptor subtypes: Structural variety raises hope for new therapy concepts | GABAA-Rezeptorsubtypen: Strukturelle Vielfalt gibt Hoffnung auf neue Therapiekonzepte Neuroforum. 21: 144-151. DOI: 10.1007/S12269-015-0025-1  0.373
2014 Obradović ALj, Joksimović S, Poe MM, Ramerstorfer J, Varagic Z, Namjoshi O, Batinić B, Radulović T, Marković B, Roth BL, Sieghart W, Cook JM, Savić MM. Sh-I-048A, an in vitro non-selective super-agonist at the benzodiazepine site of GABAA receptors: the approximated activation of receptor subtypes may explain behavioral effects. Brain Research. 1554: 36-48. PMID 24472579 DOI: 10.1016/J.Brainres.2014.01.036  0.41
2014 Mirheydari P, Ramerstorfer J, Varagic Z, Scholze P, Wimmer L, Mihovilovic MM, Sieghart W, Ernst M. Unexpected Properties of δ-Containing GABAA Receptors in Response to Ligands Interacting with the α+ β- Site. Neurochemical Research. 39: 1057-67. PMID 24072672 DOI: 10.1007/s11064-013-1156-3  0.499
2013 Yip GM, Chen ZW, Edge CJ, Smith EH, Dickinson R, Hohenester E, Townsend RR, Fuchs K, Sieghart W, Evers AS, Franks NP. A propofol binding site on mammalian GABAA receptors identified by photolabeling. Nature Chemical Biology. 9: 715-20. PMID 24056400 DOI: 10.1038/Nchembio.1340  0.432
2013 Milenkovic I, Vasiljevic M, Maurer D, Höger H, Klausberger T, Sieghart W. The parvalbumin-positive interneurons in the mouse dentate gyrus express GABAA receptor subunits α1, β2, and δ along their extrasynaptic cell membrane. Neuroscience. 254: 80-96. PMID 24055402 DOI: 10.1016/j.neuroscience.2013.09.019  0.46
2013 Joksimović S, Varagic Z, Kovačević J, Van Linn M, Milić M, Rallapalli S, Timić T, Sieghart W, Cook JM, Savić MM. Insights into functional pharmacology of α₁ GABA(A) receptors: how much does partial activation at the benzodiazepine site matter? Psychopharmacology. 230: 113-23. PMID 23685860 DOI: 10.1007/S00213-013-3143-4  0.526
2013 Varagic Z, Ramerstorfer J, Huang S, Rallapalli S, Sarto-Jackson I, Cook J, Sieghart W, Ernst M. Subtype selectivity of α+β- site ligands of GABAA receptors: identification of the first highly specific positive modulators at α6β2/3γ2 receptors. British Journal of Pharmacology. 169: 384-99. PMID 23472935 DOI: 10.1111/Bph.12153  0.494
2013 Varagic Z, Wimmer L, Schnürch M, Mihovilovic MD, Huang S, Rallapalli S, Cook JM, Mirheydari P, Ecker GF, Sieghart W, Ernst M. Identification of novel positive allosteric modulators and null modulators at the GABAA receptor α+β- interface. British Journal of Pharmacology. 169: 371-83. PMID 23472852 DOI: 10.1111/Bph.12151  0.462
2013 Sieghart W. Anxioselective anxiolytics: additional perspective. Trends in Pharmacological Sciences. 34: 145-6. PMID 23394682 DOI: 10.1016/j.tips.2013.01.005  0.42
2013 Hörtnagl H, Tasan RO, Wieselthaler A, Kirchmair E, Sieghart W, Sperk G. Patterns of mRNA and protein expression for 12 GABAA receptor subunits in the mouse brain. Neuroscience. 236: 345-72. PMID 23337532 DOI: 10.1016/J.Neuroscience.2013.01.008  0.402
2013 Namjoshi OA, Wang ZJ, Rallapalli SK, Johnson EM, Johnson YT, Ng H, Ramerstorfer J, Varagic Z, Sieghart W, Majumder S, Roth BL, Rowlett JK, Cook JM. Search for α3β₂/₃γ2 subtype selective ligands that are stable on human liver microsomes. Bioorganic & Medicinal Chemistry. 21: 93-101. PMID 23218469 DOI: 10.1016/J.Bmc.2012.10.057  0.362
2013 Joksimović S, Divljaković J, Van Linn ML, Varagic Z, Brajković G, Milinković MM, Yin W, Timić T, Sieghart W, Cook JM, Savić MM. Benzodiazepine-induced spatial learning deficits in rats are regulated by the degree of modulation of α1 GABA(A) receptors. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 23: 390-9. PMID 22633616 DOI: 10.1016/J.Euroneuro.2012.05.003  0.355
2013 Timic T, Joksimovic S, Obradovic A, Poe M, Biawat P, Ramerstorfer J, Roth B, Sieghart W, Cook J, Savic M. P.1.h.029 MK-801-induced hyperlocomotion in rats is affected by modulation of α5-containing GABAA receptors European Neuropsychopharmacology. 23: S259-S260. DOI: 10.1016/S0924-977X(13)70405-X  0.378
2012 Spurny R, Ramerstorfer J, Price K, Brams M, Ernst M, Nury H, Verheij M, Legrand P, Bertrand D, Bertrand S, Dougherty DA, de Esch IJ, Corringer PJ, Sieghart W, Lummis SC, et al. Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines. Proceedings of the National Academy of Sciences of the United States of America. 109: E3028-34. PMID 23035248 DOI: 10.1073/Pnas.1208208109  0.482
2012 Chen ZW, Manion B, Townsend RR, Reichert DE, Covey DF, Steinbach JH, Sieghart W, Fuchs K, Evers AS. Neurosteroid analog photolabeling of a site in the third transmembrane domain of the β3 subunit of the GABA(A) receptor. Molecular Pharmacology. 82: 408-19. PMID 22648971 DOI: 10.1124/Mol.112.078410  0.379
2012 Tretter V, Mukherjee J, Maric HM, Schindelin H, Sieghart W, Moss SJ. Gephyrin, the enigmatic organizer at GABAergic synapses. Frontiers in Cellular Neuroscience. 6: 23. PMID 22615685 DOI: 10.3389/Fncel.2012.00023  0.787
2012 Utkin YN, Weise C, Kasheverov IE, Andreeva TV, Kryukova EV, Zhmak MN, Starkov VG, Hoang NA, Bertrand D, Ramerstorfer J, Sieghart W, Thompson AJ, Lummis SC, Tsetlin VI. Azemiopsin from Azemiops feae viper venom, a novel polypeptide ligand of nicotinic acetylcholine receptor. The Journal of Biological Chemistry. 287: 27079-86. PMID 22613724 DOI: 10.1074/Jbc.M112.363051  0.355
2012 Sieghart W. Unravelling the role of GABAA receptor subtypes in distinct neurons and behaviour. The Journal of Physiology. 590: 2181-2. PMID 22589205 DOI: 10.1113/jphysiol.2012.231100  0.441
2012 Seeger C, Christopeit T, Fuchs K, Grote K, Sieghart W, Danielson UH. Histaminergic pharmacology of homo-oligomeric β3 γ-aminobutyric acid type A receptors characterized by surface plasmon resonance biosensor technology. Biochemical Pharmacology. 84: 341-51. PMID 22531219 DOI: 10.1016/j.bcp.2012.04.008  0.471
2012 Richter L, de Graaf C, Sieghart W, Varagic Z, Mörzinger M, de Esch IJ, Ecker GF, Ernst M. Diazepam-bound GABAA receptor models identify new benzodiazepine binding-site ligands. Nature Chemical Biology. 8: 455-64. PMID 22446838 DOI: 10.1038/Nchembio.917  0.405
2012 Sarto-Jackson I, Milenkovic I, Smalla KH, Gundelfinger ED, Kaehne T, Herrera-Molina R, Thomas S, Kiebler MA, Sieghart W. The cell adhesion molecule neuroplastin-65 is a novel interaction partner of γ-aminobutyric acid type A receptors. The Journal of Biological Chemistry. 287: 14201-14. PMID 22389504 DOI: 10.1074/Jbc.M111.293175  0.543
2012 Sieghart W, Ramerstorfer J, Sarto-Jackson I, Varagic Z, Ernst M. A novel GABA(A) receptor pharmacology: drugs interacting with the α(+) β(-) interface. British Journal of Pharmacology. 166: 476-85. PMID 22074382 DOI: 10.1111/j.1476-5381.2011.01779.x  0.542
2012 Puthenkalam R, Varagić Z, Mirheydari P, Sieghart W, Ernst M. Understanding subtype-selective allosteric modulation of GABAAreceptors Bmc Pharmacology and Toxicology. 13. DOI: 10.1186/2050-6511-13-S1-A26  0.492
2012 Seeger C, Christopeit T, Fuchs K, Grote K, Sieghart W, Danielson UH. Corrigendum to “Histaminergic pharmacology of homo-oligomeric β3 γ-aminobutyric acid type A receptors characterized by surface plasmon resonance biosensor technology” [Biochem. Pharmacol. 84 (2012) 341–351] Biochemical Pharmacology. 84: 1541. DOI: 10.1016/j.bcp.2012.09.013  0.38
2012 Chen ZW, Fuchs K, Sieghart W, Townsend RR, Evers AS. Deep amino acid sequencing of native brain GABA A receptors using high-resolution mass spectrometry Molecular and Cellular Proteomics. 11.  0.308
2011 Yang AR, Liu J, Yi HS, Warnock KT, Wang M, June HL, Puche AC, Elnabawi A, Sieghart W, Aurelian L, June HL. Binge Drinking: In Search of its Molecular Target via the GABA(A) Receptor. Frontiers in Neuroscience. 5: 123. PMID 22022305 DOI: 10.3389/Fnins.2011.00123  0.429
2011 Suryanarayanan A, Liang J, Meyer EM, Lindemeyer AK, Chandra D, Homanics GE, Sieghart W, Olsen RW, Spigelman I. Subunit Compensation and Plasticity of Synaptic GABA(A) Receptors Induced by Ethanol in α4 Subunit Knockout Mice. Frontiers in Neuroscience. 5: 110. PMID 21977012 DOI: 10.3389/Fnins.2011.00110  0.468
2011 Leppä E, Linden AM, Vekovischeva OY, Swinny JD, Rantanen V, Toppila E, Höger H, Sieghart W, Wulff P, Wisden W, Korpi ER. Removal of GABA(A) receptor γ2 subunits from parvalbumin neurons causes wide-ranging behavioral alterations. Plos One. 6: e24159. PMID 21912668 DOI: 10.1371/Journal.Pone.0024159  0.447
2011 Tretter V, Kerschner B, Milenkovic I, Ramsden SL, Ramerstorfer J, Saiepour L, Maric HM, Moss SJ, Schindelin H, Harvey RJ, Sieghart W, Harvey K. Molecular basis of the γ-aminobutyric acid A receptor α3 subunit interaction with the clustering protein gephyrin. The Journal of Biological Chemistry. 286: 37702-11. PMID 21880742 DOI: 10.1074/Jbc.M111.291336  0.783
2011 Shrivastava AN, Triller A, Sieghart W. GABA(A) Receptors: Post-Synaptic Co-Localization and Cross-Talk with Other Receptors. Frontiers in Cellular Neuroscience. 5: 7. PMID 21734865 DOI: 10.3389/fncel.2011.00007  0.527
2011 Corteen NL, Cole TM, Sarna A, Sieghart W, Swinny JD. Localization of GABA-A receptor alpha subunits on neurochemically distinct cell types in the rat locus coeruleus. The European Journal of Neuroscience. 34: 250-62. PMID 21692880 DOI: 10.1111/j.1460-9568.2011.07740.x  0.534
2011 Liu J, Yang AR, Kelly T, Puche A, Esoga C, June HL, Elnabawi A, Merchenthaler I, Sieghart W, June HL, Aurelian L. Binge alcohol drinking is associated with GABAA alpha2-regulated Toll-like receptor 4 (TLR4) expression in the central amygdala. Proceedings of the National Academy of Sciences of the United States of America. 108: 4465-70. PMID 21368176 DOI: 10.1073/Pnas.1019020108  0.408
2011 Shrivastava AN, Triller A, Sieghart W, Sarto-Jackson I. Regulation of GABA(A) receptor dynamics by interaction with purinergic P2X(2) receptors. The Journal of Biological Chemistry. 286: 14455-68. PMID 21343285 DOI: 10.1074/jbc.M110.165282  0.449
2011 Ramerstorfer J, Furtmüller R, Sarto-Jackson I, Varagic Z, Sieghart W, Ernst M. The GABAA receptor alpha+beta- interface: a novel target for subtype selective drugs. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 870-7. PMID 21248110 DOI: 10.1523/JNEUROSCI.5012-10.2011  0.518
2011 Gross A, Sims RE, Swinny JD, Sieghart W, Bolam JP, Stanford IM. Differential localization of GABA(A) receptor subunits in relation to rat striatopallidal and pallidopallidal synapses. The European Journal of Neuroscience. 33: 868-78. PMID 21219474 DOI: 10.1111/j.1460-9568.2010.07552.x  0.476
2011 Shen Y, Lindemeyer AK, Spigelman I, Sieghart W, Olsen RW, Liang J. Plasticity of GABAA receptors after ethanol pre-exposure in cultured hippocampal neurons. Molecular Pharmacology. 79: 432-42. PMID 21163967 DOI: 10.1124/Mol.110.068650  0.469
2011 Kasugai Y, Vogel E, Hauschild M, Tasan RO, Peterschmitt Y, Lüthi A, Shigemoto R, Sieghart W, Singewald N, Sperk G, Ferraguti F. Fear learning induces structural and functional plasticity at GABAergic synapses in the basolateral amygdala Bmc Pharmacology. 11: A42. DOI: 10.1186/1471-2210-11-S2-A42  0.36
2010 Kasugai Y, Swinny JD, Roberts JD, Dalezios Y, Fukazawa Y, Sieghart W, Shigemoto R, Somogyi P. Quantitative localisation of synaptic and extrasynaptic GABAA receptor subunits on hippocampal pyramidal cells by freeze-fracture replica immunolabelling. The European Journal of Neuroscience. 32: 1868-88. PMID 21073549 DOI: 10.1111/j.1460-9568.2010.07473.x  0.512
2010 Abramian AM, Comenencia-Ortiz E, Vithlani M, Tretter EV, Sieghart W, Davies PA, Moss SJ. Protein kinase C phosphorylation regulates membrane insertion of GABAA receptor subtypes that mediate tonic inhibition. The Journal of Biological Chemistry. 285: 41795-805. PMID 20940303 DOI: 10.1074/Jbc.M110.149229  0.645
2010 Fischer BD, Licata SC, Edwankar RV, Wang ZJ, Huang S, He X, Yu J, Zhou H, Johnson EM, Cook JM, Furtmüller R, Ramerstorfer J, Sieghart W, Roth BL, Majumder S, et al. Anxiolytic-like effects of 8-acetylene imidazobenzodiazepines in a rhesus monkey conflict procedure. Neuropharmacology. 59: 612-8. PMID 20727364 DOI: 10.1016/J.Neuropharm.2010.08.011  0.513
2010 Ramerstorfer J, Furtmüller R, Vogel E, Huck S, Sieghart W. The point mutation gamma 2F77I changes the potency and efficacy of benzodiazepine site ligands in different GABAA receptor subtypes. European Journal of Pharmacology. 636: 18-27. PMID 20303942 DOI: 10.1016/j.ejphar.2010.03.015  0.521
2010 Savić MM, Majumder S, Huang S, Edwankar RV, Furtmüller R, Joksimović S, Clayton T, Ramerstorfer J, Milinković MM, Roth BL, Sieghart W, Cook JM. Novel positive allosteric modulators of GABAA receptors: do subtle differences in activity at alpha1 plus alpha5 versus alpha2 plus alpha3 subunits account for dissimilarities in behavioral effects in rats? Progress in Neuro-Psychopharmacology & Biological Psychiatry. 34: 376-86. PMID 20074611 DOI: 10.1016/J.Pnpbp.2010.01.004  0.525
2010 Kasugai Y, Hauschild M, Sieghart W, Shigemoto R, Singewald N, Ferraguti F. Fear learning triggers structural changes at GABAergic synapses in the basal amygdala Bmc Pharmacology. 10. DOI: 10.1186/1471-2210-10-S1-A34  0.4
2010 Joksimovic SM, Huang S, Ramerstorfer J, Milinkovic MM, Divljakovic JM, Roth BL, Sieghart W, Savic MM, Cook JM. P.1.c.044 SH-I-048A, a novel positive modulator of GABA-A receptor: in vitro and behavioral profile European Neuropsychopharmacology. 20. DOI: 10.1016/S0924-977X(10)70331-X  0.431
2009 Tretter V, Revilla-Sanchez R, Houston C, Terunuma M, Havekes R, Florian C, Jurd R, Vithlani M, Michels G, Couve A, Sieghart W, Brandon N, Abel T, Smart TG, Moss SJ. Deficits in spatial memory correlate with modified {gamma}-aminobutyric acid type A receptor tyrosine phosphorylation in the hippocampus. Proceedings of the National Academy of Sciences of the United States of America. 106: 20039-44. PMID 19903874 DOI: 10.1073/Pnas.0908840106  0.772
2009 Kang SU, Fuchs K, Sieghart W, Pollak A, Csaszar E, Lubec G. Gel-based mass spectrometric analysis of a strongly hydrophobic GABAA-receptor subunit containing four transmembrane domains. Nature Protocols. 4: 1093-102. PMID 19707190 DOI: 10.1038/nprot.2009.92  0.381
2009 Marchionni I, Kasap Z, Mozrzymas JW, Sieghart W, Cherubini E, Zacchi P. New insights on the role of gephyrin in regulating both phasic and tonic GABAergic inhibition in rat hippocampal neurons in culture. Neuroscience. 164: 552-62. PMID 19660531 DOI: 10.1016/j.neuroscience.2009.07.063  0.528
2009 Atucha E, Hammerschmidt F, Zolle I, Sieghart W, Berger ML. Structure-activity relationship of etomidate derivatives at the GABA(A) receptor: Comparison with binding to 11beta-hydroxylase. Bioorganic & Medicinal Chemistry Letters. 19: 4284-7. PMID 19497738 DOI: 10.1016/j.bmcl.2009.05.065  0.494
2009 Rivas FM, Stables JP, Murphree L, Edwankar RV, Edwankar CR, Huang S, Jain HD, Zhou H, Majumder S, Sankar S, Roth BL, Ramerstorfer J, Furtmüller R, Sieghart W, Cook JM. Antiseizure activity of novel gamma-aminobutyric acid (A) receptor subtype-selective benzodiazepine analogues in mice and rat models. Journal of Medicinal Chemistry. 52: 1795-8. PMID 19275170 DOI: 10.1021/Jm801652D  0.384
2009 Olsen RW, Sieghart W. GABA A receptors: subtypes provide diversity of function and pharmacology. Neuropharmacology. 56: 141-8. PMID 18760291 DOI: 10.1016/j.neuropharm.2008.07.045  0.524
2009 Baburin I, Khom S, Timin E, Hohaus A, Sieghart W, Hering S. Benzodiazepines modulate GABAA receptors by reducing a gamma-subunit-mediated inhibition of GABA sensitivity Bmc Pharmacology. 9: A23. DOI: 10.1186/1471-2210-9-S2-A23  0.519
2009 Joksimovic SM, Savic MM, Milinkovic MM, Linn MV, Ramerstorfer J, Majumder S, Yin W, Roth BL, Sieghart W, Cook JM. P.1.d.018 WYS-8, a novel ligand at GABAA receptors: a step forward to linking in vitro with in vivo selectivity? European Neuropsychopharmacology. 19. DOI: 10.1016/S0924-977X(09)70440-7  0.352
2009 Milinkovic MM, Savic MM, Huang S, Furtmüller R, Majumder S, Samardic J, Divljakovic JM, Roth BL, Sieghart W, Cook JM. P.1.d.016 Jy-xhe-053, a benzodiazepine ligand less efficacious at GABAA receptors containing alphal and alpha5 than alpha2 and alpha3 subunits European Neuropsychopharmacology. 19. DOI: 10.1016/S0924-977X(09)70438-9  0.401
2008 Choi DS, Wei W, Deitchman JK, Kharazia VN, Lesscher HM, McMahon T, Wang D, Qi ZH, Sieghart W, Zhang C, Shokat KM, Mody I, Messing RO. Protein kinase Cdelta regulates ethanol intoxication and enhancement of GABA-stimulated tonic current. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 11890-9. PMID 19005054 DOI: 10.1523/Jneurosci.3156-08.2008  0.46
2008 Olsen RW, Sieghart W. International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. Update. Pharmacological Reviews. 60: 243-60. PMID 18790874 DOI: 10.1124/pr.108.00505  0.538
2008 Han D, Holger Försterling F, Li X, Deschamps JR, Parrish D, Cao H, Rallapalli S, Clayton T, Teng Y, Majumder S, Sankar S, Roth BL, Sieghart W, Furtmuller R, Rowlett JK, et al. A study of the structure-activity relationship of GABA(A)-benzodiazepine receptor bivalent ligands by conformational analysis with low temperature NMR and X-ray analysis. Bioorganic & Medicinal Chemistry. 16: 8853-62. PMID 18790643 DOI: 10.1016/J.Bmc.2008.08.072  0.402
2008 Furtmueller R, Furtmueller B, Ramerstorfer J, Paladini AC, Wasowski C, Marder M, Huck S, Sieghart W. 6,3'-Dinitroflavone is a low efficacy modulator of GABA(A) receptors. European Journal of Pharmacology. 591: 142-6. PMID 18639544 DOI: 10.1016/j.ejphar.2008.06.093  0.571
2008 Baburin I, Khom S, Timin E, Hohaus A, Sieghart W, Hering S. Estimating the efficiency of benzodiazepines on GABA(A) receptors comprising gamma1 or gamma2 subunits. British Journal of Pharmacology. 155: 424-33. PMID 18604239 DOI: 10.1038/bjp.2008.271  0.534
2008 Kang SU, Fuchs K, Sieghart W, Lubec G. Gel-based mass spectrometric analysis of recombinant GABA(A) receptor subunits representing strongly hydrophobic transmembrane proteins. Journal of Proteome Research. 7: 3498-506. PMID 18563923 DOI: 10.1021/pr800236u  0.557
2008 Harris D, Clayton T, Cook J, Sahbaie P, Halliwell RF, Furtmüller R, Huck S, Sieghart W, DeLorey TM. Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit. Journal of Medicinal Chemistry. 51: 3788-803. PMID 18537233 DOI: 10.1021/Jm701433B  0.431
2008 Sarto-Jackson I, Sieghart W. Assembly of GABA(A) receptors (Review). Molecular Membrane Biology. 25: 302-10. PMID 18446616 DOI: 10.1080/09687680801914516  0.567
2008 Savić MM, Clayton T, Furtmüller R, Gavrilović I, Samardzić J, Savić S, Huck S, Sieghart W, Cook JM. PWZ-029, a compound with moderate inverse agonist functional selectivity at GABA(A) receptors containing alpha5 subunits, improves passive, but not active, avoidance learning in rats. Brain Research. 1208: 150-9. PMID 18394590 DOI: 10.1016/J.Brainres.2008.02.020  0.518
2008 Terunuma M, Xu J, Vithlani M, Sieghart W, Kittler J, Pangalos M, Haydon PG, Coulter DA, Moss SJ. Deficits in phosphorylation of GABA(A) receptors by intimately associated protein kinase C activity underlie compromised synaptic inhibition during status epilepticus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 376-84. PMID 18184780 DOI: 10.1523/JNEUROSCI.4346-07.2008  0.646
2008 Payne HL, Ives JH, Sieghart W, Thompson CL. AMPA and kainate receptors mediate mutually exclusive effects on GABA(A) receptor expression in cultured mouse cerebellar granule neurones. Journal of Neurochemistry. 104: 173-86. PMID 17986225 DOI: 10.1111/j.1471-4159.2007.04989.x  0.453
2008 Savić MM, Huang S, Furtmüller R, Clayton T, Huck S, Obradović DI, Ugresić ND, Sieghart W, Bokonjić DR, Cook JM. Are GABAA receptors containing alpha5 subunits contributing to the sedative properties of benzodiazepine site agonists? Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 332-9. PMID 17392731 DOI: 10.1038/Sj.Npp.1301403  0.49
2008 Peterschmitt Y, Weger S, Plauth A, Heilbronn R, Wisden W, Sperk G, Sieghart W. Establishing a new mouse model for investigating the function of amygdala neurons in anxiety Bmc Pharmacology. 8: A35. DOI: 10.1186/1471-2210-8-S1-A35  0.442
2008 Samardzic J, Savic MM, Clayton T, Rallapalli S, Obradovic DI, Joksimovic SM, Sieghart W, Cook JM. P.1.g.021 Effects of a novel inverse agonist selective for alpha5 GABAA receptors on spatial memory: comparison with the standard non-selective inverse agonist DMCM European Neuropsychopharmacology. 18. DOI: 10.1016/S0924-977X(08)70377-8  0.385
2008 Joksimovic S, Savic MM, Clayton T, Huang S, Ara S, Linn MV, Milinkovic MM, Bokonjic DR, Sieghart W, Cook JM. P.1.g.016 Relative contribution of the alpha2-, 3- and 5-containing GABAA receptors to benzodiazepine effects in the water maze European Neuropsychopharmacology. 18. DOI: 10.1016/S0924-977X(08)70372-9  0.409
2007 Clayton T, Chen JL, Ernst M, Richter L, Cromer BA, Morton CJ, Ng H, Kaczorowski CC, Helmstetter FJ, Furtmüller R, Ecker G, Parker MW, Sieghart W, Cook JM. An updated unified pharmacophore model of the benzodiazepine binding site on gamma-aminobutyric acid(a) receptors: correlation with comparative models. Current Medicinal Chemistry. 14: 2755-75. PMID 18045122 DOI: 10.2174/092986707782360097  0.428
2007 Payne HL, Connelly WM, Ives JH, Lehner R, Furtmuller B, Sieghart W, Tiwari P, Lucocq JM, Lees G, Thompson CL. GABAA alpha6-containing receptors are selectively compromised in cerebellar granule cells of the ataxic mouse, stargazer. The Journal of Biological Chemistry. 282: 29130-43. PMID 17646167 DOI: 10.1074/Jbc.M700111200  0.574
2007 Wulff P, Goetz T, Leppä E, Linden AM, Renzi M, Swinny JD, Vekovischeva OY, Sieghart W, Somogyi P, Korpi ER, Farrant M, Wisden W. From synapse to behavior: rapid modulation of defined neuronal types with engineered GABAA receptors. Nature Neuroscience. 10: 923-9. PMID 17572671 DOI: 10.1515/Nf-2007-0405  0.438
2007 Pytel M, Wójtowicz T, Mercik K, Sarto-Jackson I, Sieghart W, Ikonomidou C, Mozrzymas JW. 17 beta-estradiol modulates GABAergic synaptic transmission and tonic currents during development in vitro. Neuropharmacology. 52: 1342-53. PMID 17418284 DOI: 10.1016/j.neuropharm.2007.01.014  0.415
2007 Sarto-Jackson I, Furtmueller R, Ernst M, Huck S, Sieghart W. Spontaneous cross-link of mutated alpha1 subunits during GABA(A) receptor assembly. The Journal of Biological Chemistry. 282: 4354-63. PMID 17148454 DOI: 10.1074/jbc.M609676200  0.544
2007 Savic MM, Clayton T, Furtmüller R, Gavrilovic I, Savic S, Sieghart W, Cook JM. P.1.c.040 Electrophysiological and behavioral profile of a GABAA alpha5 subtype-functionally selective negative modulator European Neuropsychopharmacology. 17. DOI: 10.1016/S0924-977X(07)70364-4  0.329
2006 Sieghart W. Structure, pharmacology, and function of GABAA receptor subtypes. Advances in Pharmacology (San Diego, Calif.). 54: 231-63. PMID 17175817 DOI: 10.1016/S1054-3589(06)54010-4  0.544
2006 Payne HL, Donoghue PS, Connelly WM, Hinterreiter S, Tiwari P, Ives JH, Hann V, Sieghart W, Lees G, Thompson CL. Aberrant GABA(A) receptor expression in the dentate gyrus of the epileptic mutant mouse stargazer. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 8600-8. PMID 16914686 DOI: 10.1523/JNEUROSCI.1088-06.2006  0.501
2006 Hanchar HJ, Chutsrinopkun P, Meera P, Supavilai P, Sieghart W, Wallner M, Olsen RW. Ethanol potently and competitively inhibits binding of the alcohol antagonist Ro15-4513 to alpha4/6beta3delta GABAA receptors. Proceedings of the National Academy of Sciences of the United States of America. 103: 8546-51. PMID 16581914 DOI: 10.1073/Pnas.0509903103  0.463
2006 Swanwick CC, Murthy NR, Mtchedlishvili Z, Sieghart W, Kapur J. Development of gamma-aminobutyric acidergic synapses in cultured hippocampal neurons. The Journal of Comparative Neurology. 495: 497-510. PMID 16498682 DOI: 10.1002/cne.20897  0.437
2006 Sarto-Jackson I, Ramerstorfer J, Ernst M, Sieghart W. Identification of amino acid residues important for assembly of GABA receptor alpha1 and gamma2 subunits. Journal of Neurochemistry. 96: 983-95. PMID 16412095 DOI: 10.1111/j.1471-4159.2005.03626.x  0.528
2006 Ogris W, Lehner R, Fuchs K, Furtmüller B, Höger H, Homanics GE, Sieghart W. Investigation of the abundance and subunit composition of GABAA receptor subtypes in the cerebellum of alpha1-subunit-deficient mice. Journal of Neurochemistry. 96: 136-47. PMID 16277610 DOI: 10.1111/J.1471-4159.2005.03509.X  0.448
2006 Khom S, Baburin I, Timin EN, Hohaus A, Sieghart W, Hering S. Pharmacological properties of GABAA receptors containing gamma1 subunits. Molecular Pharmacology. 69: 640-9. PMID 16272224 DOI: 10.1124/mol.105.017236  0.536
2005 Ernst M, Bruckner S, Boresch S, Sieghart W. Comparative models of GABAA receptor extracellular and transmembrane domains: important insights in pharmacology and function. Molecular Pharmacology. 68: 1291-300. PMID 16103045 DOI: 10.1124/Mol.105.015982  0.413
2005 Cope DW, Halbsguth C, Karayannis T, Wulff P, Ferraguti F, Hoeger H, Leppä E, Linden AM, Oberto A, Ogris W, Korpi ER, Sieghart W, Somogyi P, Wisden W, Capogna M. Loss of zolpidem efficacy in the hippocampus of mice with the GABAA receptor gamma2 F77I point mutation. The European Journal of Neuroscience. 21: 3002-16. PMID 15978011 DOI: 10.1111/J.1460-9568.2005.04127.X  0.52
2005 Mangan PS, Sun C, Carpenter M, Goodkin HP, Sieghart W, Kapur J. Cultured Hippocampal Pyramidal Neurons Express Two Kinds of GABAA Receptors. Molecular Pharmacology. 67: 775-88. PMID 15613639 DOI: 10.1124/mol.104.007385  0.501
2004 Sun C, Sieghart W, Kapur J. Distribution of alpha1, alpha4, gamma2, and delta subunits of GABAA receptors in hippocampal granule cells. Brain Research. 1029: 207-16. PMID 15542076 DOI: 10.1016/j.brainres.2004.09.056  0.426
2004 Ogris W, Pöltl A, Hauer B, Ernst M, Oberto A, Wulff P, Höger H, Wisden W, Sieghart W. Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABA(A) receptor gamma2 subunit. Biochemical Pharmacology. 68: 1621-9. PMID 15451405 DOI: 10.1016/J.Bcp.2004.07.020  0.488
2004 Sinkkonen ST, Vekovischeva OY, Möykkynen T, Ogris W, Sieghart W, Wisden W, Korpi ER. Behavioural correlates of an altered balance between synaptic and extrasynaptic GABAAergic inhibition in a mouse model. The European Journal of Neuroscience. 20: 2168-78. PMID 15450096 DOI: 10.1111/J.1460-9568.2004.03684.X  0.532
2004 Petrini EM, Marchionni I, Zacchi P, Sieghart W, Cherubini E. Clustering of extrasynaptic GABA(A) receptors modulates tonic inhibition in cultured hippocampal neurons. The Journal of Biological Chemistry. 279: 45833-43. PMID 15317810 DOI: 10.1074/jbc.M407229200  0.507
2004 Cope DW, Wulff P, Oberto A, Aller MI, Capogna M, Ferraguti F, Halbsguth C, Hoeger H, Jolin HE, Jones A, McKenzie AN, Ogris W, Poeltl A, Sinkkonen ST, Vekovischeva OY, ... ... Sieghart W, et al. Abolition of zolpidem sensitivity in mice with a point mutation in the GABAA receptor gamma2 subunit. Neuropharmacology. 47: 17-34. PMID 15165831 DOI: 10.1016/J.Neuropharm.2004.03.007  0.438
2004 Mitterhauser M, Wadsak W, Wabnegger L, Mien LK, Tögel S, Langer O, Sieghart W, Viernstein H, Kletter K, Dudczak R. Biological evaluation of 2'-[18F]fluoroflumazenil ([18F]FFMZ), a potential GABA receptor ligand for PET. Nuclear Medicine and Biology. 31: 291-5. PMID 15013496 DOI: 10.1016/j.nucmedbio.2003.09.003  0.432
2003 Pöltl A, Hauer B, Fuchs K, Tretter V, Sieghart W. Subunit composition and quantitative importance of GABA(A) receptor subtypes in the cerebellum of mouse and rat. Journal of Neurochemistry. 87: 1444-55. PMID 14713300 DOI: 10.1046/J.1471-4159.2003.02135.X  0.783
2003 Li X, Cao H, Zhang C, Furtmueller R, Fuchs K, Huck S, Sieghart W, Deschamps J, Cook JM. Synthesis, in vitro affinity, and efficacy of a bis 8-ethynyl-4H-imidazo[1,5a]- [1,4]benzodiazepine analogue, the first bivalent alpha5 subtype selective BzR/GABA(A) antagonist. Journal of Medicinal Chemistry. 46: 5567-70. PMID 14667209 DOI: 10.1021/Jm034164C  0.471
2003 Pirker S, Schwarzer C, Czech T, Baumgartner C, Pockberger H, Maier H, Hauer B, Sieghart W, Furtinger S, Sperk G. Increased expression of GABA(A) receptor beta-subunits in the hippocampus of patients with temporal lobe epilepsy. Journal of Neuropathology and Experimental Neurology. 62: 820-34. PMID 14503638 DOI: 10.1093/JNEN/62.8.820  0.541
2003 Mitterhauser M, Wadsak W, Wabnegger L, Sieghart W, Viernstein H, Kletter K, Dudczak R. In vivo and in vitro evaluation of [18F]FETO with respect to the adrenocortical and GABAergic system in rats. European Journal of Nuclear Medicine and Molecular Imaging. 30: 1398-401. PMID 12845489 DOI: 10.1007/s00259-003-1252-8  0.352
2003 Ernst M, Brauchart D, Boresch S, Sieghart W. Comparative modeling of GABA(A) receptors: limits, insights, future developments. Neuroscience. 119: 933-43. PMID 12831854 DOI: 10.1016/S0306-4522(03)00288-4  0.483
2003 Ehya N, Sarto I, Wabnegger L, Sieghart W. Identification of an amino acid sequence within GABA(A) receptor beta3 subunits that is important for receptor assembly. Journal of Neurochemistry. 84: 127-35. PMID 12485409 DOI: 10.1046/j.1471-4159.2003.01509.x  0.484
2003 Keenan CM, Esfandyari T, Sieghart W, Sharkey KA. Localization of a functional GABA-A receptor in the guinea pig myenteric plexus Gastroenterology. 124: A136. DOI: 10.1016/S0016-5085(03)80674-1  0.398
2002 Wisden W, Cope D, Klausberger T, Hauer B, Sinkkonen ST, Tretter V, Lujan R, Jones A, Korpi ER, Mody I, Sieghart W, Somogyi P. Ectopic expression of the GABA(A) receptor alpha6 subunit in hippocampal pyramidal neurons produces extrasynaptic receptors and an increased tonic inhibition. Neuropharmacology. 43: 530-49. PMID 12367600 DOI: 10.1016/S0028-3908(02)00151-X  0.781
2002 Sarto I, Wabnegger L, Dögl E, Sieghart W. Homologous sites of GABA(A) receptor alpha(1), beta(3) and gamma(2) subunits are important for assembly. Neuropharmacology. 43: 482-91. PMID 12367595 DOI: 10.1016/S0028-3908(02)00160-0  0.555
2002 Sieghart W, Sperk G. Subunit composition, distribution and function of GABA(A) receptor subtypes. Current Topics in Medicinal Chemistry. 2: 795-816. PMID 12171572  0.48
2002 Kumar S, Sieghart W, Morrow AL. Association of protein kinase C with GABA(A) receptors containing alpha1 and alpha4 subunits in the cerebral cortex: selective effects of chronic ethanol consumption. Journal of Neurochemistry. 82: 110-7. PMID 12091471 DOI: 10.1046/J.1471-4159.2002.00943.X  0.532
2002 Sarto I, Klausberger T, Ehya N, Mayer B, Fuchs K, Sieghart W. A novel site on gamma 3 subunits important for assembly of GABA(A) receptors. The Journal of Biological Chemistry. 277: 30656-64. PMID 12065588 DOI: 10.1074/jbc.M203597200  0.512
2002 El Hadri A, Abouabdellah A, Thomet U, Baur R, Furtmüller R, Sigel E, Sieghart W, Dodd RH. N-Substituted 4-amino-3,3-dipropyl-2(3H)-furanones: new positive allosteric modulators of the GABA(A) receptor sharing electrophysiological properties with the anticonvulsant loreclezole. Journal of Medicinal Chemistry. 45: 2824-31. PMID 12061884 DOI: 10.1021/jm011082k  0.499
2002 Peng Z, Hauer B, Mihalek RM, Homanics GE, Sieghart W, Olsen RW, Houser CR. GABA(A) receptor changes in delta subunit-deficient mice: altered expression of alpha4 and gamma2 subunits in the forebrain. The Journal of Comparative Neurology. 446: 179-97. PMID 11932935 DOI: 10.1002/Cne.10210  0.533
2002 Korpi ER, Mihalek RM, Sinkkonen ST, Hauer B, Hevers W, Homanics GE, Sieghart W, Lüddens H. Altered receptor subtypes in the forebrain of GABA(A) receptor delta subunit-deficient mice: recruitment of gamma 2 subunits. Neuroscience. 109: 733-43. PMID 11927155 DOI: 10.1016/S0306-4522(01)00527-9  0.551
2002 Furtmüller R, Schlag MG, Berger M, Hopf R, Huck S, Sieghart W, Redl H. Tranexamic acid, a widely used antifibrinolytic agent, causes convulsions by a gamma-aminobutyric acid(A) receptor antagonistic effect. The Journal of Pharmacology and Experimental Therapeutics. 301: 168-73. PMID 11907171 DOI: 10.1124/jpet.301.1.168  0.539
2001 Dellovade TL, Davis AM, Ferguson C, Sieghart W, Homanics GE, Tobet SA. GABA influences the development of the ventromedial nucleus of the hypothalamus. Journal of Neurobiology. 49: 264-76. PMID 11745664 DOI: 10.1002/Neu.10011  0.512
2001 Klausberger T, Sarto I, Ehya N, Fuchs K, Furtmuller R, Mayer B, Huck S, Sieghart W. Alternate use of distinct intersubunit contacts controls GABAA receptor assembly and stoichiometry. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 9124-33. PMID 11717345 DOI: 10.1523/Jneurosci.21-23-09124.2001  0.518
2001 Sigel E, Baur R, Furtmueller R, Razet R, Dodd RH, Sieghart W. Differential cross talk of ROD compounds with the benzodiazepine binding site. Molecular Pharmacology. 59: 1470-7. PMID 11353808 DOI: 10.1124/Mol.59.6.1470  0.33
2001 Schwarzer C, Berresheim U, Pirker S, Wieselthaler A, Fuchs K, Sieghart W, Sperk G. Distribution of the major gamma-aminobutyric acid(A) receptor subunits in the basal ganglia and associated limbic brain areas of the adult rat. The Journal of Comparative Neurology. 433: 526-49. PMID 11304716 DOI: 10.1002/cne.1158  0.522
2001 Klausberger T, Ehya N, Fuchs K, Fuchs T, Ebert V, Sarto I, Sieghart W. Detection and binding properties of GABA(A) receptor assembly intermediates. The Journal of Biological Chemistry. 276: 16024-32. PMID 11278514 DOI: 10.1074/jbc.M009508200  0.479
2001 Maric D, Liu QY, Maric I, Chaudry S, Chang YH, Smith SV, Sieghart W, Fritschy JM, Barker JL. GABA expression dominates neuronal lineage progression in the embryonic rat neocortex and facilitates neurite outgrowth via GABA(A) autoreceptor/Cl- channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 2343-60. PMID 11264309 DOI: 10.1523/Jneurosci.21-07-02343.2001  0.431
2001 Saha S, Sieghart W, Fritschy JM, McWilliam PN, Batten TF. Gamma-aminobutyric acid receptor (GABA(A)) subunits in rat nucleus tractus solitarii (NTS) revealed by polymerase chain reaction (PCR) and immunohistochemistry. Molecular and Cellular Neurosciences. 17: 241-57. PMID 11161482 DOI: 10.1006/mcne.2000.0919  0.386
2001 Tretter V, Hauer B, Nusser Z, Mihalek RM, Höger H, Homanics GE, Somogyi P, Sieghart W. Targeted disruption of the GABA(A) receptor delta subunit gene leads to an up-regulation of gamma 2 subunit-containing receptors in cerebellar granule cells. The Journal of Biological Chemistry. 276: 10532-8. PMID 11136737 DOI: 10.1074/Jbc.M011054200  0.767
2001 Buhr A, Wagner C, Fuchs K, Sieghart W, Sigel E. Two novel residues in M2 of the gamma-aminobutyric acid type A receptor affecting gating by GABA and picrotoxin affinity. The Journal of Biological Chemistry. 276: 7775-81. PMID 11114302 DOI: 10.1074/jbc.M008907200  0.529
2000 Louiset E, McKernan R, Sieghart W, Vaudry H. Subunit Composition and Pharmacological Characterization ofγ -Aminobutyric Acid Type A Receptors in Frog Pituitary Melanotrophs. Endocrinology. 141: 1083-1092. PMID 28200864 DOI: 10.1210/endo.141.3.7397  0.337
2000 Sieghart W. Unraveling the function of GABA(A) receptor subtypes. Trends in Pharmacological Sciences. 21: 411-3. PMID 11121567 DOI: 10.1016/S0165-6147(00)01564-9  0.539
2000 Pirker S, Schwarzer C, Wieselthaler A, Sieghart W, Sperk G. GABA(A) receptors: immunocytochemical distribution of 13 subunits in the adult rat brain. Neuroscience. 101: 815-50. PMID 11113332 DOI: 10.1016/S0306-4522(00)00442-5  0.452
2000 Do-Rego JL, Mensah-Nyagan GA, Beaujean D, Vaudry D, Sieghart W, Luu-The V, Pelletier G, Vaudry H. gamma-Aminobutyric acid, acting through gamma -aminobutyric acid type A receptors, inhibits the biosynthesis of neurosteroids in the frog hypothalamus. Proceedings of the National Academy of Sciences of the United States of America. 97: 13925-30. PMID 11087816 DOI: 10.1073/Pnas.240269897  0.55
2000 Razet R, Thomet U, Furtmüller R, Chiaroni A, Sigel E, Sieghart W, Dodd RH. 5-[1'-(2'-N-Arylsulfonyl-1',2',3',4'-tetrahydroisoquinolyl)]-4, 5-dihydro-2(3H)-furanones: positive allosteric modulators of the GABA(A) receptor with a new mode of action. Journal of Medicinal Chemistry. 43: 4363-6. PMID 11087560 DOI: 10.1021/jm001049i  0.438
2000 Razet R, Thomet U, Furtmüller R, Jursky F, Sigel E, Sieghart W, Dodd RH. Use of bicuculline, a GABA antagonist, as a template for the development of a new class of ligands showing positive allosteric modulation of the GABA(A) receptor. Bioorganic & Medicinal Chemistry Letters. 10: 2579-83. PMID 11086734 DOI: 10.1016/S0960-894X(00)00514-X  0.515
2000 Thomet U, Baur R, Razet R, Dodd RH, Furtmüller R, Sieghart W, Sigel E. A novel positive allosteric modulator of the GABA(A) receptor: the action of (+)-ROD188. British Journal of Pharmacology. 131: 843-50. PMID 11030736 DOI: 10.1038/sj.bjp.0703558  0.51
2000 Simonian SX, Skynner MJ, Sieghart W, Essrich C, Luscher B, Herbison AE. Role of the GABA(A) receptor gamma2 subunit in the development of gonadotropin-releasing hormone neurons in vivo. The European Journal of Neuroscience. 12: 3488-96. PMID 11029618 DOI: 10.1046/J.1460-9568.2000.00225.X  0.456
2000 Brandon NJ, Delmas P, Kittler JT, McDonald BJ, Sieghart W, Brown DA, Smart TG, Moss SJ. GABAA receptor phosphorylation and functional modulation in cortical neurons by a protein kinase C-dependent pathway. The Journal of Biological Chemistry. 275: 38856-62. PMID 10978327 DOI: 10.1074/Jbc.M004910200  0.602
2000 Uusi-Oukari M, Heikkilä J, Sinkkonen ST, Mäkelä R, Hauer B, Homanics GE, Sieghart W, Wisden W, Korpi ER. Long-range interactions in neuronal gene expression: evidence from gene targeting in the GABA(A) receptor beta2-alpha6-alpha1-gamma2 subunit gene cluster. Molecular and Cellular Neurosciences. 16: 34-41. PMID 10882481 DOI: 10.1006/Mcne.2000.0856  0.464
2000 Sassoè-Pognetto M, Panzanelli P, Sieghart W, Fritschy JM. Colocalization of multiple GABA(A) receptor subtypes with gephyrin at postsynaptic sites. The Journal of Comparative Neurology. 420: 481-98. PMID 10805922 DOI: 10.1002/(Sici)1096-9861(20000515)420:4<481::Aid-Cne6>3.0.Co;2-5  0.528
2000 Nicoletti D, Ghini AA, Furtmüller R, Sieghart W, Dodd RH, Burton G. Synthesis and GABA(A) receptor activity of 6-oxa-analogs of neurosteroids. Steroids. 65: 349-56. PMID 10802285 DOI: 10.1016/S0039-128X(00)00088-X  0.443
2000 Klausberger T, Fuchs K, Mayer B, Ehya N, Sieghart W. GABA(A) receptor assembly. Identification and structure of gamma(2) sequences forming the intersubunit contacts with alpha(1) and beta(3) subunits. The Journal of Biological Chemistry. 275: 8921-8. PMID 10722739 DOI: 10.1074/jbc.275.12.8921  0.544
2000 Okada M, Onodera K, Van Renterghem C, Sieghart W, Takahashi T. Functional correlation of GABA(A) receptor alpha subunits expression with the properties of IPSCs in the developing thalamus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 2202-8. PMID 10704495  0.424
2000 Louiset E, McKernan R, Sieghart W, Vaudry H. Subunit composition and pharmacological characterization of gamma-aminobutyric acid type A receptors in frog pituitary melanotrophs. Endocrinology. 141: 1083-92. PMID 10698184 DOI: 10.1210/endo.141.3.7397  0.542
2000 Jursky F, Fuchs K, Buhr A, Tretter V, Sigel E, Sieghart W. Identification of amino acid residues of GABA(A) receptor subunits contributing to the formation and affinity of the tert-butylbicyclophosphorothionate binding site. Journal of Neurochemistry. 74: 1310-6. PMID 10693965  0.745
2000 Okada M, Onodera K, Renterghem CV, Sieghart W, Takahashi T. Functional Correlation of GABAA Receptor α Subunits Expression with the Properties of IPSCs in the Developing Thalamus The Journal of Neuroscience. 20: 2202-2208. DOI: 10.1523/Jneurosci.20-06-02202.2000  0.406
1999 Nusser Z, Sieghart W, Mody I. Differential regulation of synaptic GABAA receptors by cAMP-dependent protein kinase in mouse cerebellar and olfactory bulb neurones. The Journal of Physiology. 521: 421-35. PMID 10581313 DOI: 10.1111/J.1469-7793.1999.00421.X  0.419
1999 Mihalek RM, Banerjee PK, Korpi ER, Quinlan JJ, Firestone LL, Mi ZP, Lagenaur C, Tretter V, Sieghart W, Anagnostaras SG, Sage JR, Fanselow MS, Guidotti A, Spigelman I, Li Z, et al. Attenuated sensitivity to neuroactive steroids in gamma-aminobutyrate type A receptor delta subunit knockout mice. Proceedings of the National Academy of Sciences of the United States of America. 96: 12905-10. PMID 10536021 DOI: 10.1073/Pnas.96.22.12905  0.744
1999 Feucht M, Fuchs K, Pichlbauer E, Hornik K, Scharfetter J, Goessler R, Füreder T, Cvetkovic N, Sieghart W, Kasper S, Aschauer H. Possible association between childhood absence epilepsy and the gene encoding GABRB3. Biological Psychiatry. 46: 997-1002. PMID 10509183 DOI: 10.1016/S0006-3223(99)00039-6  0.361
1999 Gustincich S, Feigenspan A, Sieghart W, Raviola E. Composition of the GABA(A) receptors of retinal dopaminergic neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 7812-22. PMID 10479684 DOI: 10.1523/Jneurosci.19-18-07812.1999  0.534
1999 Lévi S, Chesnoy-Marchais D, Sieghart W, Triller A. Synaptic control of glycine and GABA(A) receptors and gephyrin expression in cultured motoneurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 7434-49. PMID 10460250 DOI: 10.1523/Jneurosci.19-17-07434.1999  0.501
1999 Thomet U, Baur R, Scholze P, Sieghart W, Sigel E. Dual mode of stimulation by the beta-carboline ZK 91085 of recombinant GABA(A) receptor currents: molecular determinants affecting its action. British Journal of Pharmacology. 127: 1231-9. PMID 10455270 DOI: 10.1038/sj.bjp.0702639  0.443
1999 Thomet U, Furtmüller R, Sieghart W, Le Hyaric-Almeida M, Rousseau JF, Dodd RH, Venault P, Chapouthier G, Sigel E. EDPC: a novel high affinity ligand for the benzodiazepine site on rat GABA(A) receptors. Neuroscience Letters. 269: 63-6. PMID 10430505 DOI: 10.1016/S0304-3940(99)00431-0  0.452
1999 Chen S, Huang X, Zeng XJ, Sieghart W, Tietz EI. Benzodiazepine-mediated regulation of alpha1, alpha2, beta1-3 and gamma2 GABA(A) receptor subunit proteins in the rat brain hippocampus and cortex. Neuroscience. 93: 33-44. PMID 10430468 DOI: 10.1016/S0306-4522(99)00118-9  0.381
1999 Kannenberg K, Schaerer MT, Fuchs K, Sieghart W, Sigel E. A novel serine kinase with specificity for beta3-subunits is tightly associated with GABA(A) receptors. The Journal of Biological Chemistry. 274: 21257-64. PMID 10409683  0.377
1999 Ebert V, Scholze P, Fuchs K, Sieghart W. Identification of subunits mediating clustering of GABA(A) receptors by rapsyn. Neurochemistry International. 34: 453-63. PMID 10397374 DOI: 10.1016/S0197-0186(99)00039-X  0.449
1999 Sieghart W, Fuchs K, Tretter V, Ebert V, Jechlinger M, Höger H, Adamiker D. Structure and subunit composition of GABA(A) receptors. Neurochemistry International. 34: 379-85. PMID 10397365 DOI: 10.1016/S0197-0186(99)00045-5  0.779
1999 Bencsits E, Ebert V, Tretter V, Sieghart W. A significant part of native gamma-aminobutyric AcidA receptors containing alpha4 subunits do not contain gamma or delta subunits. The Journal of Biological Chemistry. 274: 19613-6. PMID 10391897 DOI: 10.1074/jbc.274.28.19613  0.752
1999 Maric D, Maric I, Wen X, Fritschy JM, Sieghart W, Barker JL, Serafini R. GABAA receptor subunit composition and functional properties of Cl- channels with differential sensitivity to zolpidem in embryonic rat hippocampal cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 4921-37. PMID 10366626 DOI: 10.1523/Jneurosci.19-12-04921.1999  0.505
1999 Nusser Z, Ahmad Z, Tretter V, Fuchs K, Wisden W, Sieghart W, Somogyi P. Alterations in the expression of GABAA receptor subunits in cerebellar granule cells after the disruption of the alpha6 subunit gene. The European Journal of Neuroscience. 11: 1685-97. PMID 10215922 DOI: 10.1046/J.1460-9568.1999.00581.X  0.752
1999 Kannenberg K, Sieghart W, Reuter H. Clusters of GABAA receptors on cultured hippocampal cells correlate only partially with functional synapses. The European Journal of Neuroscience. 11: 1256-64. PMID 10103120 DOI: 10.1046/J.1460-9568.1999.00533.X  0.516
1999 Tobet SA, Henderson RG, Whiting PJ, Sieghart W. Special relationship of gamma-aminobutyric acid to the ventromedial nucleus of the hypothalamus during embryonic development. The Journal of Comparative Neurology. 405: 88-98. PMID 10022198 DOI: 10.1002/(Sici)1096-9861(19990301)405:1<88::Aid-Cne7>3.0.Co;2-0  0.486
1998 Serafini R, Ma W, Maric D, Maric I, Lahjouji F, Sieghart W, Barker JL. Initially expressed early rat embryonic GABA(A) receptor Cl- ion channels exhibit heterogeneous channel properties. The European Journal of Neuroscience. 10: 1771-83. PMID 9751149 DOI: 10.1046/j.1460-9568.1998.00187.x  0.507
1998 Mitsuyama H, Little KY, Sieghart W, Devaud LL, Morrow AL. GABA(A) receptor alpha1, alpha4, and beta3 subunit mRNA and protein expression in the frontal cortex of human alcoholics. Alcoholism, Clinical and Experimental Research. 22: 815-22. PMID 9660306 DOI: 10.1111/J.1530-0277.1998.Tb03873.X  0.434
1998 Barnard EA, Skolnick P, Olsen RW, Mohler H, Sieghart W, Biggio G, Braestrup C, Bateson AN, Langer SZ. International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function. Pharmacological Reviews. 50: 291-313. PMID 9647870  0.396
1998 Jechlinger M, Pelz R, Tretter V, Klausberger T, Sieghart W. Subunit composition and quantitative importance of hetero-oligomeric receptors: GABAA receptors containing alpha6 subunits. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 2449-57. PMID 9502805  0.732
1998 Matthews DB, Devaud LL, Fritschy JM, Sieghart W, Morrow AL. Differential regulation of GABA(A) receptor gene expression by ethanol in the rat hippocampus versus cerebral cortex. Journal of Neurochemistry. 70: 1160-6. PMID 9489737 DOI: 10.1046/J.1471-4159.1998.70031160.X  0.498
1998 Nusser Z, Sieghart W, Somogyi P. Segregation of different GABAA receptors to synaptic and extrasynaptic membranes of cerebellar granule cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 1693-703. PMID 9464994 DOI: 10.1523/Jneurosci.18-05-01693.1998  0.53
1998 Jechlinger M, Pelz R, Tretter V, Klausberger T, Sieghart W. Subunit Composition and Quantitative Importance of Hetero-oligomeric Receptors: GABAA Receptors Containing α6 Subunits The Journal of Neuroscience. 18: 2449-2457. DOI: 10.1523/Jneurosci.18-07-02449.1998  0.723
1998 Aschauer HN, Scharfetter J, Homik K, Fuchs K, Gerhard E, Gebhardt C, Lenzinger E, Meszarost K, Sieghart W, Kasper S. No association between tardive dyskinesia and serotonin 2a receptor gene mutations European Neuropsychopharmacology. 8. DOI: 10.1016/S0924-977X(98)80380-5  0.309
1998 Aschauer HN, Scharfetter J, Fuchs K, Gerhard E, Gebhardt C, Lenzinger E, Meszaros K, Hornik K, Sieghart W, Kasper S. Tardive dyskinesia and dopamine 3 receptor gene mutation European Psychiatry. 13: 231s-231s. DOI: 10.1016/S0924-9338(99)80290-9  0.307
1997 Tsunashima K, Schwarzer C, Kirchmair E, Sieghart W, Sperk G. GABA(A) receptor subunits in the rat hippocampus III: altered messenger RNA expression in kainic acid-induced epilepsy. Neuroscience. 80: 1019-32. PMID 9284057 DOI: 10.1016/S0306-4522(97)00144-9  0.348
1997 Schwarzer C, Tsunashima K, Wanzenböck C, Fuchs K, Sieghart W, Sperk G. GABA(A) receptor subunits in the rat hippocampus II: altered distribution in kainic acid-induced temporal lobe epilepsy. Neuroscience. 80: 1001-17. PMID 9284056 DOI: 10.1016/S0306-4522(97)00145-0  0.49
1997 Sperk G, Schwarzer C, Tsunashima K, Fuchs K, Sieghart W. GABA(A) receptor subunits in the rat hippocampus I: immunocytochemical distribution of 13 subunits. Neuroscience. 80: 987-1000. PMID 9284055 DOI: 10.1016/S0306-4522(97)00146-2  0.54
1997 Devaud LL, Fritschy JM, Sieghart W, Morrow AL. Bidirectional alterations of GABA(A) receptor subunit peptide levels in rat cortex during chronic ethanol consumption and withdrawal. Journal of Neurochemistry. 69: 126-30. PMID 9202302 DOI: 10.1046/J.1471-4159.1997.69010126.X  0.397
1997 Maric D, Maric I, Ma W, Lahojuji F, Somogyi R, Wen X, Sieghart W, Fritschy JM, Barker JL. Anatomical gradients in proliferation and differentiation of embryonic rat CNS accessed by buoyant density fractionation: alpha 3, beta 3 and gamma 2 GABAA receptor subunit co-expression by post-mitotic neocortical neurons correlates directly with cell buoyancy. The European Journal of Neuroscience. 9: 507-22. PMID 9104593 DOI: 10.1111/J.1460-9568.1997.Tb01628.X  0.324
1997 Tretter V, Ehya N, Fuchs K, Sieghart W. Stoichiometry and assembly of a recombinant GABAA receptor subtype. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 2728-37. PMID 9092594 DOI: 10.1523/Jneurosci.17-08-02728.1997  0.752
1997 Jones A, Korpi ER, McKernan RM, Pelz R, Nusser Z, Mäkelä R, Mellor JR, Pollard S, Bahn S, Stephenson FA, Randall AD, Sieghart W, Somogyi P, Smith AJ, Wisden W. Ligand-gated ion channel subunit partnerships: GABAA receptor alpha6 subunit gene inactivation inhibits delta subunit expression. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 1350-62. PMID 9006978 DOI: 10.1523/Jneurosci.17-04-01350.1997  0.475
1997 Scharfetter J, Feucht M, Fuchs K, Füreder T, Gößler R, Cvetkovic N, Pichlbauer E, Sieghart W, Kasper S, Aschauer HN. Association of GABAA receptor subunit genes with childhood absence epilepsy Biological Psychiatry. 42: 166. DOI: 10.1016/S0006-3223(97)87569-5  0.414
1996 Somogyi P, Fritschy JM, Benke D, Roberts JD, Sieghart W. The gamma 2 subunit of the GABAA receptor is concentrated in synaptic junctions containing the alpha 1 and beta 2/3 subunits in hippocampus, cerebellum and globus pallidus. Neuropharmacology. 35: 1425-44. PMID 9014159 DOI: 10.1016/S0028-3908(96)00086-X  0.49
1996 Ebert V, Scholze P, Sieghart W. Extensive heterogeneity of recombinant gamma-aminobutyric acidA receptors expressed in alpha 4 beta 3 gamma 2-transfected human embryonic kidney 293 cells. Neuropharmacology. 35: 1323-30. PMID 9014148 DOI: 10.1016/S0028-3908(96)00062-7  0.482
1996 Nusser Z, Sieghart W, Benke D, Fritschy JM, Somogyi P. Differential synaptic localization of two major gamma-aminobutyric acid type A receptor alpha subunits on hippocampal pyramidal cells. Proceedings of the National Academy of Sciences of the United States of America. 93: 11939-44. PMID 8876241 DOI: 10.1073/pnas.93.21.11939  0.471
1996 Scholze P, Ebert V, Sieghart W. Affinity of various ligands for GABAA receptors containing alpha 4 beta 3 gamma 2, alpha 4 gamma 2, or alpha 1 beta 3 gamma 2 subunits. European Journal of Pharmacology. 304: 155-62. PMID 8813598 DOI: 10.1016/0014-2999(96)00088-X  0.478
1996 Zezula J, Slany A, Sieghart W. Interaction of allosteric ligands with GABAA receptors containing one, two, or three different subunits. European Journal of Pharmacology. 301: 207-14. PMID 8773466 DOI: 10.1016/0014-2999(96)00066-0  0.451
1996 Marksteiner J, Kaufmann W, Pfaller K, Sieghart W, Saria A. Striatal efferents preferentially innervate neurons in the ventral pallidum containing GABAA receptor alpha 1 subunit-like immunoreactivity. Synapse (New York, N.Y.). 23: 107-14. PMID 8723715 DOI: 10.1002/(SICI)1098-2396(199606)23:2<107::AID-SYN6>3.0.CO;2-D  0.306
1996 Nusser Z, Sieghart W, Stephenson FA, Somogyi P. The alpha 6 subunit of the GABAA receptor is concentrated in both inhibitory and excitatory synapses on cerebellar granule cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 103-14. PMID 8613776 DOI: 10.1523/Jneurosci.16-01-00103.1996  0.348
1996 Todd AJ, Watt C, Spike RC, Sieghart W. Colocalization of GABA, glycine, and their receptors at synapses in the rat spinal cord. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 974-82. PMID 8558266 DOI: 10.1523/Jneurosci.16-03-00974.1996  0.491
1996 Aschauer HN, Stompe T, Fureder T, Fuchs K, Gerhard E, Sieghart W, Meszaros K, Kasper S. Normal personality traits related to neurotransmitter receptor genes Psychiatric Genetics. 6: 164. DOI: 10.1097/00041444-199623000-00080  0.344
1995 Slany A, Zezula J, Fuchs K, Sieghart W. Allosteric modulation of [3H]flunitrazepam binding to recombinant GABAA receptors. European Journal of Pharmacology. 291: 99-105. PMID 8566181 DOI: 10.1016/0922-4106(95)90130-2  0.519
1995 Zezula J, Karall S, Dodd RH, Sieghart W. [3H]propyl-6-azido-beta-carboline-3-carboxylate: a new photoaffinity label for the GABAA-benzodiazepine receptor. European Journal of Pharmacology. 281: 93-6. PMID 8566124 DOI: 10.1016/0014-2999(95)00284-R  0.421
1995 Fuchs K, Zezula J, Slany A, Sieghart W. Endogenous [3H]flunitrazepam binding in human embryonic kidney cell line 293. European Journal of Pharmacology. 289: 87-95. PMID 7781715 DOI: 10.1016/0922-4106(95)90172-8  0.42
1995 Fenelon VS, Sieghart W, Herbison AE. Cellular localization and differential distribution of GABAA receptor subunit proteins and messenger RNAs within hypothalamic magnocellular neurons. Neuroscience. 64: 1129-43. PMID 7753380 DOI: 10.1016/0306-4522(94)00402-Q  0.371
1995 Nusser Z, Roberts JD, Baude A, Richards JG, Sieghart W, Somogyi P. Immunocytochemical localization of the alpha 1 and beta 2/3 subunits of the GABAA receptor in relation to specific GABAergic synapses in the dentate gyrus. The European Journal of Neuroscience. 7: 630-46. PMID 7620614 DOI: 10.1111/j.1460-9568.1995.tb00667.x  0.406
1995 Sieghart W. Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes. Pharmacological Reviews. 47: 181-234. PMID 7568326  0.387
1995 Slany A, Zezula J, Tretter V, Sieghart W. Rat beta 3 subunits expressed in human embryonic kidney 293 cells form high affinity [35S]t-butylbicyclophosphorothionate binding sites modulated by several allosteric ligands of gamma-aminobutyric acid type A receptors. Molecular Pharmacology. 48: 385-91. PMID 7565617  0.725
1994 Tögel M, Mossier B, Fuchs K, Sieghart W. gamma-Aminobutyric acidA receptors displaying association of gamma 3-subunits with beta 2/3 and different alpha-subunits exhibit unique pharmacological properties. The Journal of Biological Chemistry. 269: 12993-8. PMID 8175718  0.429
1994 Sieghart W. Pharmacology of benzodiazepine receptors: an update. Journal of Psychiatry & Neuroscience : Jpn. 19: 24-9. PMID 8148363  0.345
1994 Item C, Sieghart W. Binding of gamma-aminobutyric acidA receptors to tubulin. Journal of Neurochemistry. 63: 1119-25. PMID 8051553 DOI: 10.1046/j.1471-4159.1994.63031119.x  0.467
1994 Mossier B, Tögel M, Fuchs K, Sieghart W. Immunoaffinity purification of gamma-aminobutyric acidA (GABAA) receptors containing gamma 1-subunits. Evidence for the presence of a single type of gamma-subunit in GABAA receptors. The Journal of Biological Chemistry. 269: 25777-82. PMID 7929282  0.436
1994 Inglefield JR, Sieghart W, Kellogg CK. Immunohistochemical and neurochemical evidence for GABAA receptor heterogeneity between the hypothalamus and cortex. Journal of Chemical Neuroanatomy. 7: 243-52. PMID 7873096 DOI: 10.1016/0891-0618(94)90016-7  0.4
1993 Sieghart W, Item C, Buchstaller A, Fuchs K, Höger H, Adamiker D. Evidence for the existence of differential O-glycosylated alpha 5-subunits of the gamma-aminobutyric acidA receptor in the rat brain. Journal of Neurochemistry. 60: 93-8. PMID 8380199 DOI: 10.1111/j.1471-4159.1993.tb05826.x  0.446
1993 Mhatre MC, Pena G, Sieghart W, Ticku MK. Antibodies specific for GABAA receptor alpha subunits reveal that chronic alcohol treatment down-regulates alpha-subunit expression in rat brain regions. Journal of Neurochemistry. 61: 1620-5. PMID 8228981 DOI: 10.1111/j.1471-4159.1993.tb09795.x  0.425
1992 Sieghart W. GABAA receptors: ligand-gated Cl- ion channels modulated by multiple drug-binding sites. Trends in Pharmacological Sciences. 13: 446-50. PMID 1338138 DOI: 10.1016/0165-6147(92)90142-S  0.488
1992 Sieghart W. Molecular basis of pharmacological heterogeneity of GABAA receptors. Cellular Signalling. 4: 231-7. PMID 1324699  0.316
1992 Sieghart W, Fuchs K, Zezula J, Buchstaller A, Zimprich F, Lassmann H. Biochemical, immunological, and pharmacological characterization of GABAA-benzodiazepine receptor subtypes. Advances in Biochemical Psychopharmacology. 47: 155-62. PMID 1324569  0.368
1992 Sieghart W. Heterogeneity of GABAA receptors. Clinical Neuropharmacology. 15: 681A-682A. PMID 1323413  0.347
1992 Sieghart W. Pharmacology of benzodiazepine receptors: an update. Clinical Neuropharmacology. 15: 523A-524A. PMID 1323404 DOI: 10.1097/00002826-199201001-00272  0.452
1991 Zimprich F, Zezula J, Sieghart W, Lassmann H. Immunohistochemical localization of the alpha 1, alpha 2 and alpha 3 subunit of the GABAA receptor in the rat brain. Neuroscience Letters. 127: 125-8. PMID 1715535 DOI: 10.1016/0304-3940(91)90910-L  0.448
1991 Buchstaller A, Adamiker D, Fuchs K, Sieghart W. N-deglycosylation and immunological identification indicates the existence of beta-subunit isoforms of the rat GABAA receptor. Febs Letters. 287: 27-30. PMID 1715287 DOI: 10.1016/0014-5793(91)80008-Q  0.398
1991 Zezula J, Fuchs K, Sieghart W. Separation of alpha 1, alpha 2 and alpha 3 subunits of the GABAA-benzodiazepine receptor complex by immunoaffinity chromatography. Brain Research. 563: 325-8. PMID 1664775 DOI: 10.1016/0006-8993(91)91556-G  0.454
1991 Buchstaller A, Fuchs K, Sieghart W. Identification of alpha 1-, alpha 2- and alpha 3-subunit isoforms of the GABAA-benzodiazepine receptor in the rat brain. Neuroscience Letters. 129: 237-41. PMID 1660579 DOI: 10.1016/0304-3940(91)90470-E  0.437
1991 Sieghart W, Schlerka W. Potency of several type I-benzodiazepine receptor ligands for inhibition of [3H]flunitrazepam binding in different rat brain tissues. European Journal of Pharmacology. 197: 103-7. PMID 1654258 DOI: 10.1016/0014-2999(91)90371-V  0.35
1991 Zezula J, Sieghart W. Isolation of type I and type II GABAA-benzodiazepine receptors by immunoaffinity chromatography. Febs Letters. 284: 15-8. PMID 1647972 DOI: 10.1016/0014-5793(91)80750-W  0.351
1991 Sieghart W. Heterogeneity of GABAA-benzodiazepine receptors. Biochemical Society Transactions. 19: 129-32. PMID 1645305  0.365
1991 Sieghart W. Proposal of a new GABAA-benzodiazepine receptor nomenclature based on the subunit composition of GABAA receptors European Neuropsychopharmacology. 1: 286-288. DOI: 10.1016/0924-977X(91)90531-X  0.362
1990 Sieghart W. [GABA(A) benzodiazepine receptors and epilepsy]. Wiener Klinische Wochenschrift. 102: 197-201. PMID 2160756  0.401
1990 Fuchs K, Adamiker D, Sieghart W. Identification of alpha 2- and alpha 3-subunits of the GABAA-benzodiazepine receptor complex purified from the brains of young rats. Febs Letters. 261: 52-4. PMID 2155135 DOI: 10.1016/0014-5793(90)80634-U  0.416
1989 Sieghart W. Multiplicity of GABAA--benzodiazepine receptors. Trends in Pharmacological Sciences. 10: 407-11. PMID 2559519 DOI: 10.1016/0165-6147(89)90189-2  0.546
1989 Fuchs K, Sieghart W. Evidence for the existence of several different alpha- and beta-subunits of the GABA/benzodiazepine receptor complex from rat brain. Neuroscience Letters. 97: 329-33. PMID 2541384 DOI: 10.1016/0304-3940(89)90619-8  0.344
1988 Fuchs K, Möhler H, Sieghart W. Various proteins from rat brain, specifically and irreversibly labeled by [3H]flunitrazepam, are distinct alpha-subunits of the GABA-benzodiazepine receptor complex. Neuroscience Letters. 90: 314-9. PMID 2458558 DOI: 10.1016/0304-3940(88)90208-X  0.405
1987 Sieghart W, Eichinger A, Zezula J. Comparison of tryptic peptides of benzodiazepine binding proteins photolabeled with [3H]flunitrazepam or [3H]Ro 15-4513. Journal of Neurochemistry. 48: 1109-14. PMID 3029327 DOI: 10.1111/J.1471-4159.1987.Tb05634.X  0.321
1986 Sieghart W. Comparison of benzodiazepine receptors in cerebellum and inferior colliculus. Journal of Neurochemistry. 47: 920-3. PMID 3016192  0.328
1985 Sieghart W. Binding of Various Benzodiazepine Receptor Ligands to Different Benzodiazepine Receptor Subtypes Pharmacopsychiatry. 18: 160-162. DOI: 10.1055/S-2007-1017355  0.318
1984 Drexler G, Sieghart W. Properties of a high affinity binding site for [3H]avermectin B1a. European Journal of Pharmacology. 99: 269-77. PMID 6329785 DOI: 10.1016/0014-2999(84)90133-X  0.431
1984 Sieghart W, Schuster A. Affinity of various ligands for benzodiazepine receptors in rat cerebellum and hippocampus. Biochemical Pharmacology. 33: 4033-8. PMID 6095867 DOI: 10.1016/0006-2952(84)90017-0  0.424
1984 Drexler G, Sieghart W. [35S]tert.-butylbicyclophosphorothionate and avermectin bind to different sites associated with the gamma- aminobutyric acid-benzodiazepine receptor complex. Neuroscience Letters. 50: 273-7. PMID 6093013 DOI: 10.1016/0304-3940(84)90498-1  0.335
1984 Möhler H, Sieghart W, Richards JG, Hunkeler W. Photoaffinity labeling of benzodiazepine receptors with a partial inverse agonist. European Journal of Pharmacology. 102: 191-2. PMID 6090157 DOI: 10.1016/0014-2999(84)90358-3  0.32
1984 Drexler G, Sieghart W. Evidence for association of a high affinity avermectin binding site with the benzodiazepine receptor. European Journal of Pharmacology. 101: 201-7. PMID 6088254 DOI: 10.1016/0014-2999(84)90157-2  0.425
1983 Sieghart W, Drexler G, Mayer A, Schuster A. Interaction of benzodiazepine agonists and antagonists with different benzodiazepine receptors. Advances in Biochemical Psychopharmacology. 38: 11-9. PMID 6142599  0.32
1983 Sieghart W. Several new benzodiazepines selectively interact with a benzodiazepine receptor subtype. Neuroscience Letters. 38: 73-8. PMID 6136944 DOI: 10.1016/0304-3940(83)90113-1  0.441
1983 Sieghart W, Mayer A, Drexler G. Properties of [3H]flunitrazepam binding to different benzodiazepine binding proteins. European Journal of Pharmacology. 88: 291-9. PMID 6134627 DOI: 10.1016/0014-2999(83)90579-4  0.311
1982 Singer EA, Sieghart W, Placheta P. Sedimentation and release properties of P2 fractions derived from rat cerebral cortex slices incubated with radiolabeled GABA for a short or long time period. Neurochemical Research. 6: 1193-203. PMID 7343859 DOI: 10.1007/BF00966677  0.389
1982 Sieghart W, Moehler H. [3H]clonazepam, like [3H]flunitrazepam, is a photoaffinity label for the central type of benzodiazepine receptors. European Journal of Pharmacology. 81: 171-3. PMID 6126369 DOI: 10.1016/0014-2999(82)90620-3  0.313
1980 Sieghart W, Karobath M. Molecular heterogeneity of benzodiazepine receptors. Nature. 286: 285-7. PMID 6250054 DOI: 10.1038/286285A0  0.462
1980 Placheta P, Singer E, Sieghart W, Karobath M. Properties of [3H]taurine release from crude synaptosomal fractions of rat cerebral cortex. Neurochemical Research. 4: 703-12. PMID 120936 DOI: 10.1007/BF00964467  0.353
1975 Sieghart W, Karobath M. Evidence for specific synaptosomal localization of exogenous accumulated taurine. Journal of Neurochemistry. 23: 911-5. PMID 4154973 DOI: 10.1111/j.1471-4159.1974.tb10742.x  0.353
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