werner sieghart - Publications

Affiliations: 
Medical University Vienna, Wien, Wien, Austria 
Area:
GABAA receptors

202 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Jonas O, Calligaris D, Methuku KR, Poe MM, Francois JP, Tranghese F, Changelian A, Sieghart W, Ernst M, Krummel DA, Cook JM, Pomeroy SL, Cima M, Agar NY, Langer R, et al. First In Vivo Testing of Compounds Targeting Group 3 Medulloblastomas Using an Implantable Microdevice as a New Paradigm for Drug Development. Journal of Biomedical Nanotechnology. 12: 1297-302. PMID 27319222 DOI: 10.1166/jbn.2016.2262  0.8
2016 Ghafari M, Falsafi SK, Szodorai E, Kim EJ, Li L, Höger H, Berger J, Fuchs K, Sieghart W, Lubec G. Formation of GABAA receptor complexes containing α1 and α5 subunits is paralleling a multiple T-maze learning task in mice. Brain Structure & Function. PMID 27155990 DOI: 10.1007/s00429-016-1233-x  0.8
2016 Hoerbelt P, Ramerstorfer J, Ernst M, Sieghart W, Thomson JL, Hough LB, Fleck MW. Mutagenesis and computational docking studies support the existence of a histamine binding site at the extracellular β3+β3- interface of homooligomeric β3 GABAA receptors. Neuropharmacology. PMID 27140694 DOI: 10.1016/j.neuropharm.2016.04.042  0.8
2015 Stojanovic T, Capo I, Aronica E, Adle-Biassette H, Höger H, Sieghart W, Kovacs GG, Milenkovic I. The α1, α2, α3, and γ2 subunits of GABAA receptors show characteristic spatial and temporal expression patterns in rhombencephalic structures during normal human brain development. The Journal of Comparative Neurology. PMID 26518133 DOI: 10.1002/cne.23923  0.8
2015 Kudryavtsev DS, Shelukhina IV, Son LV, Ojomoko LO, Kryukova EV, Lyukmanova EN, Zhmak MN, Dolgikh DA, Ivanov IA, Kasheverov IE, Starkov VG, Ramerstorfer J, Sieghart W, Tsetlin VI, Utkin YN. Neurotoxins from Snake Venoms and α-Conotoxin ImI Inhibit Functionally Active Ionotropic γ-Aminobutyric Acid (GABA) Receptors. The Journal of Biological Chemistry. 290: 22747-58. PMID 26221036 DOI: 10.1074/jbc.M115.648824  0.8
2015 Sieghart W. Allosteric modulation of GABAA receptors via multiple drug-binding sites. Advances in Pharmacology (San Diego, Calif.). 72: 53-96. PMID 25600367 DOI: 10.1016/bs.apha.2014.10.002  0.8
2015 Ramerstorfer J, Foppa V, Thiery H, Hermange P, Janody S, Berger ML, Dodd RH, Sieghart W. GABA(A) receptor subtype-selectivity of novel bicuculline derivatives. Current Medicinal Chemistry. 22: 771-80. PMID 25386826  0.8
2015 Ernst M, Sieghart W. GABAA receptor subtypes: Structural variety raises hope for new therapy concepts | GABAA-Rezeptorsubtypen: Strukturelle Vielfalt gibt Hoffnung auf neue Therapiekonzepte Neuroforum. 21: 144-151. DOI: 10.1007/S12269-015-0025-1  0.8
2014 Obradović ALj, Joksimović S, Poe MM, Ramerstorfer J, Varagic Z, Namjoshi O, Batinić B, Radulović T, Marković B, Roth BL, Sieghart W, Cook JM, Savić MM. Sh-I-048A, an in vitro non-selective super-agonist at the benzodiazepine site of GABAA receptors: the approximated activation of receptor subtypes may explain behavioral effects. Brain Research. 1554: 36-48. PMID 24472579 DOI: 10.1016/j.brainres.2014.01.036  0.8
2014 Mirheydari P, Ramerstorfer J, Varagic Z, Scholze P, Wimmer L, Mihovilovic MM, Sieghart W, Ernst M. Unexpected Properties of δ-Containing GABAA Receptors in Response to Ligands Interacting with the α+ β- Site. Neurochemical Research. 39: 1057-67. PMID 24072672 DOI: 10.1007/s11064-013-1156-3  0.8
2013 Yip GM, Chen ZW, Edge CJ, Smith EH, Dickinson R, Hohenester E, Townsend RR, Fuchs K, Sieghart W, Evers AS, Franks NP. A propofol binding site on mammalian GABAA receptors identified by photolabeling. Nature Chemical Biology. 9: 715-20. PMID 24056400 DOI: 10.1038/nchembio.1340  0.8
2013 Milenkovic I, Vasiljevic M, Maurer D, Höger H, Klausberger T, Sieghart W. The parvalbumin-positive interneurons in the mouse dentate gyrus express GABAA receptor subunits α1, β2, and δ along their extrasynaptic cell membrane. Neuroscience. 254: 80-96. PMID 24055402 DOI: 10.1016/j.neuroscience.2013.09.019  0.8
2013 Joksimović S, Varagic Z, Kovačević J, Van Linn M, Milić M, Rallapalli S, Timić T, Sieghart W, Cook JM, Savić MM. Insights into functional pharmacology of α₁ GABA(A) receptors: how much does partial activation at the benzodiazepine site matter? Psychopharmacology. 230: 113-23. PMID 23685860 DOI: 10.1007/s00213-013-3143-4  0.8
2013 Varagic Z, Ramerstorfer J, Huang S, Rallapalli S, Sarto-Jackson I, Cook J, Sieghart W, Ernst M. Subtype selectivity of α+β- site ligands of GABAA receptors: identification of the first highly specific positive modulators at α6β2/3γ2 receptors. British Journal of Pharmacology. 169: 384-99. PMID 23472935 DOI: 10.1111/bph.12153  0.8
2013 Varagic Z, Wimmer L, Schnürch M, Mihovilovic MD, Huang S, Rallapalli S, Cook JM, Mirheydari P, Ecker GF, Sieghart W, Ernst M. Identification of novel positive allosteric modulators and null modulators at the GABAA receptor α+β- interface. British Journal of Pharmacology. 169: 371-83. PMID 23472852 DOI: 10.1111/bph.12151  0.8
2013 Sieghart W. Anxioselective anxiolytics: additional perspective. Trends in Pharmacological Sciences. 34: 145-6. PMID 23394682 DOI: 10.1016/j.tips.2013.01.005  0.8
2013 Hörtnagl H, Tasan RO, Wieselthaler A, Kirchmair E, Sieghart W, Sperk G. Patterns of mRNA and protein expression for 12 GABAA receptor subunits in the mouse brain. Neuroscience. 236: 345-72. PMID 23337532 DOI: 10.1016/j.neuroscience.2013.01.008  0.8
2013 Namjoshi OA, Wang ZJ, Rallapalli SK, Johnson EM, Johnson YT, Ng H, Ramerstorfer J, Varagic Z, Sieghart W, Majumder S, Roth BL, Rowlett JK, Cook JM. Search for α3β₂/₃γ2 subtype selective ligands that are stable on human liver microsomes. Bioorganic & Medicinal Chemistry. 21: 93-101. PMID 23218469 DOI: 10.1016/j.bmc.2012.10.057  0.8
2013 Joksimović S, Divljaković J, Van Linn ML, Varagic Z, Brajković G, Milinković MM, Yin W, Timić T, Sieghart W, Cook JM, Savić MM. Benzodiazepine-induced spatial learning deficits in rats are regulated by the degree of modulation of α1 GABA(A) receptors. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 23: 390-9. PMID 22633616 DOI: 10.1016/j.euroneuro.2012.05.003  0.8
2012 Spurny R, Ramerstorfer J, Price K, Brams M, Ernst M, Nury H, Verheij M, Legrand P, Bertrand D, Bertrand S, Dougherty DA, de Esch IJ, Corringer PJ, Sieghart W, Lummis SC, et al. Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines. Proceedings of the National Academy of Sciences of the United States of America. 109: E3028-34. PMID 23035248 DOI: 10.1073/pnas.1208208109  0.8
2012 Chen ZW, Manion B, Townsend RR, Reichert DE, Covey DF, Steinbach JH, Sieghart W, Fuchs K, Evers AS. Neurosteroid analog photolabeling of a site in the third transmembrane domain of the β3 subunit of the GABA(A) receptor. Molecular Pharmacology. 82: 408-19. PMID 22648971 DOI: 10.1124/mol.112.078410  0.8
2012 Tretter V, Mukherjee J, Maric HM, Schindelin H, Sieghart W, Moss SJ. Gephyrin, the enigmatic organizer at GABAergic synapses. Frontiers in Cellular Neuroscience. 6: 23. PMID 22615685 DOI: 10.3389/fncel.2012.00023  0.8
2012 Utkin YN, Weise C, Kasheverov IE, Andreeva TV, Kryukova EV, Zhmak MN, Starkov VG, Hoang NA, Bertrand D, Ramerstorfer J, Sieghart W, Thompson AJ, Lummis SC, Tsetlin VI. Azemiopsin from Azemiops feae viper venom, a novel polypeptide ligand of nicotinic acetylcholine receptor. The Journal of Biological Chemistry. 287: 27079-86. PMID 22613724 DOI: 10.1074/jbc.M112.363051  0.8
2012 Sieghart W. Unravelling the role of GABAA receptor subtypes in distinct neurons and behaviour. The Journal of Physiology. 590: 2181-2. PMID 22589205 DOI: 10.1113/jphysiol.2012.231100  0.8
2012 Radner S, Celie PH, Fuchs K, Sieghart W, Sixma TK, Stornaiuolo M. Transient transfection coupled to baculovirus infection for rapid protein expression screening in insect cells. Journal of Structural Biology. 179: 46-55. PMID 22580066 DOI: 10.1016/j.jsb.2012.04.013  0.8
2012 Seeger C, Christopeit T, Fuchs K, Grote K, Sieghart W, Danielson UH. Histaminergic pharmacology of homo-oligomeric β3 γ-aminobutyric acid type A receptors characterized by surface plasmon resonance biosensor technology. Biochemical Pharmacology. 84: 341-51. PMID 22531219 DOI: 10.1016/j.bcp.2012.04.008  0.8
2012 Richter L, de Graaf C, Sieghart W, Varagic Z, Mörzinger M, de Esch IJ, Ecker GF, Ernst M. Diazepam-bound GABAA receptor models identify new benzodiazepine binding-site ligands. Nature Chemical Biology. 8: 455-64. PMID 22446838 DOI: 10.1038/nchembio.917  0.8
2012 Sarto-Jackson I, Milenkovic I, Smalla KH, Gundelfinger ED, Kaehne T, Herrera-Molina R, Thomas S, Kiebler MA, Sieghart W. The cell adhesion molecule neuroplastin-65 is a novel interaction partner of γ-aminobutyric acid type A receptors. The Journal of Biological Chemistry. 287: 14201-14. PMID 22389504 DOI: 10.1074/jbc.M111.293175  0.8
2012 Chen ZW, Fuchs K, Sieghart W, Townsend RR, Evers AS. Deep amino acid sequencing of native brain GABAA receptors using high-resolution mass spectrometry. Molecular & Cellular Proteomics : McP. 11: M111.011445. PMID 22338125 DOI: 10.1074/mcp.M111.011445  0.8
2012 Vasiljevic M, Heisler FF, Hausrat TJ, Fehr S, Milenkovic I, Kneussel M, Sieghart W. Spatio-temporal expression analysis of the calcium-binding protein calumenin in the rodent brain. Neuroscience. 202: 29-41. PMID 22178608 DOI: 10.1016/j.neuroscience.2011.11.069  0.8
2012 Sieghart W, Ramerstorfer J, Sarto-Jackson I, Varagic Z, Ernst M. A novel GABA(A) receptor pharmacology: drugs interacting with the α(+) β(-) interface. British Journal of Pharmacology. 166: 476-85. PMID 22074382 DOI: 10.1111/j.1476-5381.2011.01779.x  0.8
2012 Chen ZW, Fuchs K, Sieghart W, Townsend RR, Evers AS. Deep amino acid sequencing of native brain GABA A receptors using high-resolution mass spectrometry Molecular and Cellular Proteomics. 11.  0.8
2011 Yang AR, Liu J, Yi HS, Warnock KT, Wang M, June HL, Puche AC, Elnabawi A, Sieghart W, Aurelian L, June HL. Binge Drinking: In Search of its Molecular Target via the GABA(A) Receptor. Frontiers in Neuroscience. 5: 123. PMID 22022305 DOI: 10.3389/fnins.2011.00123  0.8
2011 Suryanarayanan A, Liang J, Meyer EM, Lindemeyer AK, Chandra D, Homanics GE, Sieghart W, Olsen RW, Spigelman I. Subunit Compensation and Plasticity of Synaptic GABA(A) Receptors Induced by Ethanol in α4 Subunit Knockout Mice. Frontiers in Neuroscience. 5: 110. PMID 21977012 DOI: 10.3389/fnins.2011.00110  0.8
2011 Leppä E, Linden AM, Vekovischeva OY, Swinny JD, Rantanen V, Toppila E, Höger H, Sieghart W, Wulff P, Wisden W, Korpi ER. Removal of GABA(A) receptor γ2 subunits from parvalbumin neurons causes wide-ranging behavioral alterations. Plos One. 6: e24159. PMID 21912668 DOI: 10.1371/journal.pone.0024159  0.8
2011 Tretter V, Kerschner B, Milenkovic I, Ramsden SL, Ramerstorfer J, Saiepour L, Maric HM, Moss SJ, Schindelin H, Harvey RJ, Sieghart W, Harvey K. Molecular basis of the γ-aminobutyric acid A receptor α3 subunit interaction with the clustering protein gephyrin. The Journal of Biological Chemistry. 286: 37702-11. PMID 21880742 DOI: 10.1074/jbc.M111.291336  0.8
2011 Shrivastava AN, Triller A, Sieghart W. GABA(A) Receptors: Post-Synaptic Co-Localization and Cross-Talk with Other Receptors. Frontiers in Cellular Neuroscience. 5: 7. PMID 21734865 DOI: 10.3389/fncel.2011.00007  0.8
2011 Corteen NL, Cole TM, Sarna A, Sieghart W, Swinny JD. Localization of GABA-A receptor alpha subunits on neurochemically distinct cell types in the rat locus coeruleus. The European Journal of Neuroscience. 34: 250-62. PMID 21692880 DOI: 10.1111/j.1460-9568.2011.07740.x  0.8
2011 Liu J, Yang AR, Kelly T, Puche A, Esoga C, June HL, Elnabawi A, Merchenthaler I, Sieghart W, June HL, Aurelian L. Binge alcohol drinking is associated with GABAA alpha2-regulated Toll-like receptor 4 (TLR4) expression in the central amygdala. Proceedings of the National Academy of Sciences of the United States of America. 108: 4465-70. PMID 21368176 DOI: 10.1073/pnas.1019020108  0.8
2011 Shrivastava AN, Triller A, Sieghart W, Sarto-Jackson I. Regulation of GABA(A) receptor dynamics by interaction with purinergic P2X(2) receptors. The Journal of Biological Chemistry. 286: 14455-68. PMID 21343285 DOI: 10.1074/jbc.M110.165282  0.8
2011 Ramerstorfer J, Furtmüller R, Sarto-Jackson I, Varagic Z, Sieghart W, Ernst M. The GABAA receptor alpha+beta- interface: a novel target for subtype selective drugs. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 870-7. PMID 21248110 DOI: 10.1523/JNEUROSCI.5012-10.2011  0.8
2011 Gross A, Sims RE, Swinny JD, Sieghart W, Bolam JP, Stanford IM. Differential localization of GABA(A) receptor subunits in relation to rat striatopallidal and pallidopallidal synapses. The European Journal of Neuroscience. 33: 868-78. PMID 21219474 DOI: 10.1111/j.1460-9568.2010.07552.x  0.8
2011 Shen Y, Lindemeyer AK, Spigelman I, Sieghart W, Olsen RW, Liang J. Plasticity of GABAA receptors after ethanol pre-exposure in cultured hippocampal neurons. Molecular Pharmacology. 79: 432-42. PMID 21163967 DOI: 10.1124/mol.110.068650  0.8
2011 Kindler J, Bailer U, de Zwaan M, Fuchs K, Leisch F, Grün B, Strnad A, Stojanovic M, Windisch J, Lennkh-Wolfsberg C, El-Giamal N, Sieghart W, Kasper S, Aschauer H. No association of the neuropeptide Y (Leu7Pro) and ghrelin gene (Arg51Gln, Leu72Met, Gln90Leu) single nucleotide polymorphisms with eating disorders. Nordic Journal of Psychiatry. 65: 203-7. PMID 21047193 DOI: 10.3109/08039488.2010.525258  0.8
2010 Kasugai Y, Swinny JD, Roberts JD, Dalezios Y, Fukazawa Y, Sieghart W, Shigemoto R, Somogyi P. Quantitative localisation of synaptic and extrasynaptic GABAA receptor subunits on hippocampal pyramidal cells by freeze-fracture replica immunolabelling. The European Journal of Neuroscience. 32: 1868-88. PMID 21073549 DOI: 10.1111/j.1460-9568.2010.07473.x  0.8
2010 Abramian AM, Comenencia-Ortiz E, Vithlani M, Tretter EV, Sieghart W, Davies PA, Moss SJ. Protein kinase C phosphorylation regulates membrane insertion of GABAA receptor subtypes that mediate tonic inhibition. The Journal of Biological Chemistry. 285: 41795-805. PMID 20940303 DOI: 10.1074/jbc.M110.149229  0.8
2010 Fischer BD, Licata SC, Edwankar RV, Wang ZJ, Huang S, He X, Yu J, Zhou H, Johnson EM, Cook JM, Furtmüller R, Ramerstorfer J, Sieghart W, Roth BL, Majumder S, et al. Anxiolytic-like effects of 8-acetylene imidazobenzodiazepines in a rhesus monkey conflict procedure. Neuropharmacology. 59: 612-8. PMID 20727364 DOI: 10.1016/j.neuropharm.2010.08.011  0.8
2010 Ramerstorfer J, Furtmüller R, Vogel E, Huck S, Sieghart W. The point mutation gamma 2F77I changes the potency and efficacy of benzodiazepine site ligands in different GABAA receptor subtypes. European Journal of Pharmacology. 636: 18-27. PMID 20303942 DOI: 10.1016/j.ejphar.2010.03.015  0.8
2010 Schosser A, Fuchs K, Scharl T, Schloegelhofer M, Kindler J, Mossaheb N, Kaufmann RM, Leisch F, Kasper S, Sieghart W, Aschauer HN. Interaction between serotonin 5-HT2A receptor gene and dopamine transporter (DAT1) gene polymorphisms influences personality trait of persistence in Austrian Caucasians. The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry. 11: 417-24. PMID 20218802 DOI: 10.3109/15622970801935586  0.8
2010 Savić MM, Majumder S, Huang S, Edwankar RV, Furtmüller R, Joksimović S, Clayton T, Ramerstorfer J, Milinković MM, Roth BL, Sieghart W, Cook JM. Novel positive allosteric modulators of GABAA receptors: do subtle differences in activity at alpha1 plus alpha5 versus alpha2 plus alpha3 subunits account for dissimilarities in behavioral effects in rats? Progress in Neuro-Psychopharmacology & Biological Psychiatry. 34: 376-86. PMID 20074611 DOI: 10.1016/j.pnpbp.2010.01.004  0.8
2009 Tretter V, Revilla-Sanchez R, Houston C, Terunuma M, Havekes R, Florian C, Jurd R, Vithlani M, Michels G, Couve A, Sieghart W, Brandon N, Abel T, Smart TG, Moss SJ. Deficits in spatial memory correlate with modified {gamma}-aminobutyric acid type A receptor tyrosine phosphorylation in the hippocampus. Proceedings of the National Academy of Sciences of the United States of America. 106: 20039-44. PMID 19903874 DOI: 10.1073/pnas.0908840106  0.8
2009 Kang SU, Fuchs K, Sieghart W, Pollak A, Csaszar E, Lubec G. Gel-based mass spectrometric analysis of a strongly hydrophobic GABAA-receptor subunit containing four transmembrane domains. Nature Protocols. 4: 1093-102. PMID 19707190 DOI: 10.1038/nprot.2009.92  0.8
2009 Marchionni I, Kasap Z, Mozrzymas JW, Sieghart W, Cherubini E, Zacchi P. New insights on the role of gephyrin in regulating both phasic and tonic GABAergic inhibition in rat hippocampal neurons in culture. Neuroscience. 164: 552-62. PMID 19660531 DOI: 10.1016/j.neuroscience.2009.07.063  0.8
2009 Atucha E, Hammerschmidt F, Zolle I, Sieghart W, Berger ML. Structure-activity relationship of etomidate derivatives at the GABA(A) receptor: Comparison with binding to 11beta-hydroxylase. Bioorganic & Medicinal Chemistry Letters. 19: 4284-7. PMID 19497738 DOI: 10.1016/j.bmcl.2009.05.065  0.8
2009 Rivas FM, Stables JP, Murphree L, Edwankar RV, Edwankar CR, Huang S, Jain HD, Zhou H, Majumder S, Sankar S, Roth BL, Ramerstorfer J, Furtmüller R, Sieghart W, Cook JM. Antiseizure activity of novel gamma-aminobutyric acid (A) receptor subtype-selective benzodiazepine analogues in mice and rat models. Journal of Medicinal Chemistry. 52: 1795-8. PMID 19275170 DOI: 10.1021/jm801652d  0.8
2009 Olsen RW, Sieghart W. GABA A receptors: subtypes provide diversity of function and pharmacology. Neuropharmacology. 56: 141-8. PMID 18760291 DOI: 10.1016/j.neuropharm.2008.07.045  0.8
2008 Olsen RW, Sieghart W. International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. Update. Pharmacological Reviews. 60: 243-60. PMID 18790874 DOI: 10.1124/pr.108.00505  0.8
2008 Han D, Holger Försterling F, Li X, Deschamps JR, Parrish D, Cao H, Rallapalli S, Clayton T, Teng Y, Majumder S, Sankar S, Roth BL, Sieghart W, Furtmuller R, Rowlett JK, et al. A study of the structure-activity relationship of GABA(A)-benzodiazepine receptor bivalent ligands by conformational analysis with low temperature NMR and X-ray analysis. Bioorganic & Medicinal Chemistry. 16: 8853-62. PMID 18790643 DOI: 10.1016/j.bmc.2008.08.072  0.8
2008 Furtmueller R, Furtmueller B, Ramerstorfer J, Paladini AC, Wasowski C, Marder M, Huck S, Sieghart W. 6,3'-Dinitroflavone is a low efficacy modulator of GABA(A) receptors. European Journal of Pharmacology. 591: 142-6. PMID 18639544 DOI: 10.1016/j.ejphar.2008.06.093  0.8
2008 Baburin I, Khom S, Timin E, Hohaus A, Sieghart W, Hering S. Estimating the efficiency of benzodiazepines on GABA(A) receptors comprising gamma1 or gamma2 subunits. British Journal of Pharmacology. 155: 424-33. PMID 18604239 DOI: 10.1038/bjp.2008.271  0.8
2008 Kang SU, Fuchs K, Sieghart W, Lubec G. Gel-based mass spectrometric analysis of recombinant GABA(A) receptor subunits representing strongly hydrophobic transmembrane proteins. Journal of Proteome Research. 7: 3498-506. PMID 18563923 DOI: 10.1021/pr800236u  0.8
2008 Harris D, Clayton T, Cook J, Sahbaie P, Halliwell RF, Furtmüller R, Huck S, Sieghart W, DeLorey TM. Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit. Journal of Medicinal Chemistry. 51: 3788-803. PMID 18537233 DOI: 10.1021/jm701433b  0.8
2008 Sarto-Jackson I, Sieghart W. Assembly of GABA(A) receptors (Review). Molecular Membrane Biology. 25: 302-10. PMID 18446616 DOI: 10.1080/09687680801914516  0.8
2008 Savić MM, Clayton T, Furtmüller R, Gavrilović I, Samardzić J, Savić S, Huck S, Sieghart W, Cook JM. PWZ-029, a compound with moderate inverse agonist functional selectivity at GABA(A) receptors containing alpha5 subunits, improves passive, but not active, avoidance learning in rats. Brain Research. 1208: 150-9. PMID 18394590 DOI: 10.1016/j.brainres.2008.02.020  0.8
2008 Terunuma M, Xu J, Vithlani M, Sieghart W, Kittler J, Pangalos M, Haydon PG, Coulter DA, Moss SJ. Deficits in phosphorylation of GABA(A) receptors by intimately associated protein kinase C activity underlie compromised synaptic inhibition during status epilepticus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 376-84. PMID 18184780 DOI: 10.1523/JNEUROSCI.4346-07.2008  0.8
2008 Payne HL, Ives JH, Sieghart W, Thompson CL. AMPA and kainate receptors mediate mutually exclusive effects on GABA(A) receptor expression in cultured mouse cerebellar granule neurones. Journal of Neurochemistry. 104: 173-86. PMID 17986225 DOI: 10.1111/j.1471-4159.2007.04989.x  0.8
2008 Savić MM, Huang S, Furtmüller R, Clayton T, Huck S, Obradović DI, Ugresić ND, Sieghart W, Bokonjić DR, Cook JM. Are GABAA receptors containing alpha5 subunits contributing to the sedative properties of benzodiazepine site agonists? Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 332-9. PMID 17392731 DOI: 10.1038/sj.npp.1301403  0.8
2007 Clayton T, Chen JL, Ernst M, Richter L, Cromer BA, Morton CJ, Ng H, Kaczorowski CC, Helmstetter FJ, Furtmüller R, Ecker G, Parker MW, Sieghart W, Cook JM. An updated unified pharmacophore model of the benzodiazepine binding site on gamma-aminobutyric acid(a) receptors: correlation with comparative models. Current Medicinal Chemistry. 14: 2755-75. PMID 18045122 DOI: 10.2174/092986707782360097  0.8
2007 Payne HL, Connelly WM, Ives JH, Lehner R, Furtmuller B, Sieghart W, Tiwari P, Lucocq JM, Lees G, Thompson CL. GABAA alpha6-containing receptors are selectively compromised in cerebellar granule cells of the ataxic mouse, stargazer. The Journal of Biological Chemistry. 282: 29130-43. PMID 17646167 DOI: 10.1074/jbc.M700111200  0.8
2007 Wulff P, Goetz T, Leppä E, Linden AM, Renzi M, Swinny JD, Vekovischeva OY, Sieghart W, Somogyi P, Korpi ER, Farrant M, Wisden W. From synapse to behavior: rapid modulation of defined neuronal types with engineered GABAA receptors. Nature Neuroscience. 10: 923-9. PMID 17572671 DOI: 10.1038/nn1927  0.8
2007 Pytel M, Wójtowicz T, Mercik K, Sarto-Jackson I, Sieghart W, Ikonomidou C, Mozrzymas JW. 17 beta-estradiol modulates GABAergic synaptic transmission and tonic currents during development in vitro. Neuropharmacology. 52: 1342-53. PMID 17418284 DOI: 10.1016/j.neuropharm.2007.01.014  0.8
2007 Schosser A, Fuchs K, Scharl T, Leisch F, Bailer U, Kasper S, Sieghart W, Hornik K, Aschauer HN. Additional support for linkage of schizophrenia and bipolar disorder to chromosome 3q29. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 17: 501-5. PMID 17344034 DOI: 10.1016/j.euroneuro.2007.01.004  0.8
2007 Sarto-Jackson I, Furtmueller R, Ernst M, Huck S, Sieghart W. Spontaneous cross-link of mutated alpha1 subunits during GABA(A) receptor assembly. The Journal of Biological Chemistry. 282: 4354-63. PMID 17148454 DOI: 10.1074/jbc.M609676200  0.8
2006 Sieghart W. Structure, pharmacology, and function of GABAA receptor subtypes. Advances in Pharmacology (San Diego, Calif.). 54: 231-63. PMID 17175817 DOI: 10.1016/S1054-3589(06)54010-4  0.8
2006 Payne HL, Donoghue PS, Connelly WM, Hinterreiter S, Tiwari P, Ives JH, Hann V, Sieghart W, Lees G, Thompson CL. Aberrant GABA(A) receptor expression in the dentate gyrus of the epileptic mutant mouse stargazer. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 8600-8. PMID 16914686 DOI: 10.1523/JNEUROSCI.1088-06.2006  0.8
2006 Hanchar HJ, Chutsrinopkun P, Meera P, Supavilai P, Sieghart W, Wallner M, Olsen RW. Ethanol potently and competitively inhibits binding of the alcohol antagonist Ro15-4513 to alpha4/6beta3delta GABAA receptors. Proceedings of the National Academy of Sciences of the United States of America. 103: 8546-51. PMID 16581914 DOI: 10.1073/pnas.0509903103  0.8
2006 Swanwick CC, Murthy NR, Mtchedlishvili Z, Sieghart W, Kapur J. Development of gamma-aminobutyric acidergic synapses in cultured hippocampal neurons. The Journal of Comparative Neurology. 495: 497-510. PMID 16498682 DOI: 10.1002/cne.20897  0.8
2006 Sarto-Jackson I, Ramerstorfer J, Ernst M, Sieghart W. Identification of amino acid residues important for assembly of GABA receptor alpha1 and gamma2 subunits. Journal of Neurochemistry. 96: 983-95. PMID 16412095 DOI: 10.1111/j.1471-4159.2005.03626.x  0.8
2006 Ogris W, Lehner R, Fuchs K, Furtmüller B, Höger H, Homanics GE, Sieghart W. Investigation of the abundance and subunit composition of GABAA receptor subtypes in the cerebellum of alpha1-subunit-deficient mice. Journal of Neurochemistry. 96: 136-47. PMID 16277610 DOI: 10.1111/j.1471-4159.2005.03509.x  0.8
2006 Khom S, Baburin I, Timin EN, Hohaus A, Sieghart W, Hering S. Pharmacological properties of GABAA receptors containing gamma1 subunits. Molecular Pharmacology. 69: 640-9. PMID 16272224 DOI: 10.1124/mol.105.017236  0.8
2006 Sieghart W. GABAA receptors as targets for different classes of drugs Drugs of the Future. 31: 685-694. DOI: 10.1358/dof.2006.031.08.1008656  0.8
2005 Ernst M, Bruckner S, Boresch S, Sieghart W. Comparative models of GABAA receptor extracellular and transmembrane domains: important insights in pharmacology and function. Molecular Pharmacology. 68: 1291-300. PMID 16103045 DOI: 10.1124/mol.105.015982  0.8
2005 Cope DW, Halbsguth C, Karayannis T, Wulff P, Ferraguti F, Hoeger H, Leppä E, Linden AM, Oberto A, Ogris W, Korpi ER, Sieghart W, Somogyi P, Wisden W, Capogna M. Loss of zolpidem efficacy in the hippocampus of mice with the GABAA receptor gamma2 F77I point mutation. The European Journal of Neuroscience. 21: 3002-16. PMID 15978011 DOI: 10.1111/j.1460-9568.2005.04127.x  0.8
2005 Mangan PS, Sun C, Carpenter M, Goodkin HP, Sieghart W, Kapur J. Cultured Hippocampal Pyramidal Neurons Express Two Kinds of GABAA Receptors. Molecular Pharmacology. 67: 775-88. PMID 15613639 DOI: 10.1124/mol.104.007385  0.8
2005 Bailer U, Wiesegger G, Leisch F, Fuchs K, Leitner I, Letmaier M, Konstantinidis A, Stastny J, Sieghart W, Hornik K, Mitterauer B, Kasper S, Aschauer HN. No association of clock gene T3111C polymorphism and affective disorders. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 15: 51-5. PMID 15572273 DOI: 10.1016/j.euroneuro.2004.05.004  0.8
2005 Sieghart W, Ernst M. Heterogeneity of GABAA receptors: Revived interest in the development of subtype-selective drugs Current Medicinal Chemistry - Central Nervous System Agents. 5: 217-242. DOI: 10.2174/1568015054863837  0.8
2004 Sun C, Sieghart W, Kapur J. Distribution of alpha1, alpha4, gamma2, and delta subunits of GABAA receptors in hippocampal granule cells. Brain Research. 1029: 207-16. PMID 15542076 DOI: 10.1016/j.brainres.2004.09.056  0.8
2004 Ogris W, Pöltl A, Hauer B, Ernst M, Oberto A, Wulff P, Höger H, Wisden W, Sieghart W. Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABA(A) receptor gamma2 subunit. Biochemical Pharmacology. 68: 1621-9. PMID 15451405 DOI: 10.1016/j.bcp.2004.07.020  0.8
2004 Sinkkonen ST, Vekovischeva OY, Möykkynen T, Ogris W, Sieghart W, Wisden W, Korpi ER. Behavioural correlates of an altered balance between synaptic and extrasynaptic GABAAergic inhibition in a mouse model. The European Journal of Neuroscience. 20: 2168-78. PMID 15450096 DOI: 10.1111/j.1460-9568.2004.03684.x  0.8
2004 Petrini EM, Marchionni I, Zacchi P, Sieghart W, Cherubini E. Clustering of extrasynaptic GABA(A) receptors modulates tonic inhibition in cultured hippocampal neurons. The Journal of Biological Chemistry. 279: 45833-43. PMID 15317810 DOI: 10.1074/jbc.M407229200  0.8
2004 Cope DW, Wulff P, Oberto A, Aller MI, Capogna M, Ferraguti F, Halbsguth C, Hoeger H, Jolin HE, Jones A, McKenzie AN, Ogris W, Poeltl A, Sinkkonen ST, Vekovischeva OY, ... ... Sieghart W, et al. Abolition of zolpidem sensitivity in mice with a point mutation in the GABAA receptor gamma2 subunit. Neuropharmacology. 47: 17-34. PMID 15165831 DOI: 10.1016/j.neuropharm.2004.03.007  0.8
2004 Mitterhauser M, Wadsak W, Wabnegger L, Mien LK, Tögel S, Langer O, Sieghart W, Viernstein H, Kletter K, Dudczak R. Biological evaluation of 2'-[18F]fluoroflumazenil ([18F]FFMZ), a potential GABA receptor ligand for PET. Nuclear Medicine and Biology. 31: 291-5. PMID 15013496 DOI: 10.1016/j.nucmedbio.2003.09.003  0.8
2004 Schosser A, Fuchs K, Leisch F, Bailer U, Meszaros K, Lenzinger E, Willinger U, Strobl R, Heiden A, Gebhardt C, Kasper S, Sieghart W, Hornik K, Aschauer HN. Possible linkage of schizophrenia and bipolar affective disorder to chromosome 3q29; a follow-up. Journal of Psychiatric Research. 38: 357-64. PMID 15003442 DOI: 10.1016/j.jpsychires.2003.11.004  0.8
2003 Pöltl A, Hauer B, Fuchs K, Tretter V, Sieghart W. Subunit composition and quantitative importance of GABA(A) receptor subtypes in the cerebellum of mouse and rat. Journal of Neurochemistry. 87: 1444-55. PMID 14713300  0.8
2003 Li X, Cao H, Zhang C, Furtmueller R, Fuchs K, Huck S, Sieghart W, Deschamps J, Cook JM. Synthesis, in vitro affinity, and efficacy of a bis 8-ethynyl-4H-imidazo[1,5a]- [1,4]benzodiazepine analogue, the first bivalent alpha5 subtype selective BzR/GABA(A) antagonist. Journal of Medicinal Chemistry. 46: 5567-70. PMID 14667209 DOI: 10.1021/jm034164c  0.8
2003 Willeit M, Praschak-Rieder N, Neumeister A, Zill P, Leisch F, Stastny J, Hilger E, Thierry N, Konstantinidis A, Winkler D, Fuchs K, Sieghart W, Aschauer H, Ackenheil M, Bondy B, et al. A polymorphism (5-HTTLPR) in the serotonin transporter promoter gene is associated with DSM-IV depression subtypes in seasonal affective disorder. Molecular Psychiatry. 8: 942-6. PMID 14593433 DOI: 10.1038/sj.mp.4001392  0.8
2003 Pirker S, Schwarzer C, Czech T, Baumgartner C, Pockberger H, Maier H, Hauer B, Sieghart W, Furtinger S, Sperk G. Increased expression of GABA(A) receptor beta-subunits in the hippocampus of patients with temporal lobe epilepsy. Journal of Neuropathology and Experimental Neurology. 62: 820-34. PMID 14503638  0.8
2003 Mitterhauser M, Wadsak W, Wabnegger L, Sieghart W, Viernstein H, Kletter K, Dudczak R. In vivo and in vitro evaluation of [18F]FETO with respect to the adrenocortical and GABAergic system in rats. European Journal of Nuclear Medicine and Molecular Imaging. 30: 1398-401. PMID 12845489 DOI: 10.1007/s00259-003-1252-8  0.8
2003 Ernst M, Brauchart D, Boresch S, Sieghart W. Comparative modeling of GABA(A) receptors: limits, insights, future developments. Neuroscience. 119: 933-43. PMID 12831854 DOI: 10.1016/S0306-4522(03)00288-4  0.8
2003 Ehya N, Sarto I, Wabnegger L, Sieghart W. Identification of an amino acid sequence within GABA(A) receptor beta3 subunits that is important for receptor assembly. Journal of Neurochemistry. 84: 127-35. PMID 12485409 DOI: 10.1046/j.1471-4159.2003.01509.x  0.8
2002 Wisden W, Cope D, Klausberger T, Hauer B, Sinkkonen ST, Tretter V, Lujan R, Jones A, Korpi ER, Mody I, Sieghart W, Somogyi P. Ectopic expression of the GABA(A) receptor alpha6 subunit in hippocampal pyramidal neurons produces extrasynaptic receptors and an increased tonic inhibition. Neuropharmacology. 43: 530-49. PMID 12367600 DOI: 10.1016/S0028-3908(02)00151-X  0.8
2002 Sarto I, Wabnegger L, Dögl E, Sieghart W. Homologous sites of GABA(A) receptor alpha(1), beta(3) and gamma(2) subunits are important for assembly. Neuropharmacology. 43: 482-91. PMID 12367595 DOI: 10.1016/S0028-3908(02)00160-0  0.8
2002 Sieghart W, Sperk G. Subunit composition, distribution and function of GABA(A) receptor subtypes. Current Topics in Medicinal Chemistry. 2: 795-816. PMID 12171572  0.8
2002 Kumar S, Sieghart W, Morrow AL. Association of protein kinase C with GABA(A) receptors containing alpha1 and alpha4 subunits in the cerebral cortex: selective effects of chronic ethanol consumption. Journal of Neurochemistry. 82: 110-7. PMID 12091471 DOI: 10.1046/j.1471-4159.2002.00943.x  0.8
2002 Bailer U, Leisch F, Meszaros K, Lenzinger E, Willinger U, Strobl R, Heiden A, Gebhardt C, Döge E, Fuchs K, Sieghart W, Kasper S, Hornik K, Aschauer HN. Genome scan for susceptibility loci for schizophrenia and bipolar disorder. Biological Psychiatry. 52: 40-52. PMID 12079729 DOI: 10.1016/S0006-3223(02)01320-3  0.8
2002 Sarto I, Klausberger T, Ehya N, Mayer B, Fuchs K, Sieghart W. A novel site on gamma 3 subunits important for assembly of GABA(A) receptors. The Journal of Biological Chemistry. 277: 30656-64. PMID 12065588 DOI: 10.1074/jbc.M203597200  0.8
2002 El Hadri A, Abouabdellah A, Thomet U, Baur R, Furtmüller R, Sigel E, Sieghart W, Dodd RH. N-Substituted 4-amino-3,3-dipropyl-2(3H)-furanones: new positive allosteric modulators of the GABA(A) receptor sharing electrophysiological properties with the anticonvulsant loreclezole. Journal of Medicinal Chemistry. 45: 2824-31. PMID 12061884 DOI: 10.1021/jm011082k  0.8
2002 Peng Z, Hauer B, Mihalek RM, Homanics GE, Sieghart W, Olsen RW, Houser CR. GABA(A) receptor changes in delta subunit-deficient mice: altered expression of alpha4 and gamma2 subunits in the forebrain. The Journal of Comparative Neurology. 446: 179-97. PMID 11932935 DOI: 10.1002/cne.10210  0.8
2002 Korpi ER, Mihalek RM, Sinkkonen ST, Hauer B, Hevers W, Homanics GE, Sieghart W, Lüddens H. Altered receptor subtypes in the forebrain of GABA(A) receptor delta subunit-deficient mice: recruitment of gamma 2 subunits. Neuroscience. 109: 733-43. PMID 11927155 DOI: 10.1016/S0306-4522(01)00527-9  0.8
2002 Furtmüller R, Schlag MG, Berger M, Hopf R, Huck S, Sieghart W, Redl H. Tranexamic acid, a widely used antifibrinolytic agent, causes convulsions by a gamma-aminobutyric acid(A) receptor antagonistic effect. The Journal of Pharmacology and Experimental Therapeutics. 301: 168-73. PMID 11907171 DOI: 10.1124/jpet.301.1.168  0.8
2001 Dellovade TL, Davis AM, Ferguson C, Sieghart W, Homanics GE, Tobet SA. GABA influences the development of the ventromedial nucleus of the hypothalamus. Journal of Neurobiology. 49: 264-76. PMID 11745664 DOI: 10.1002/neu.10011  0.8
2001 Klausberger T, Sarto I, Ehya N, Fuchs K, Furtmuller R, Mayer B, Huck S, Sieghart W. Alternate use of distinct intersubunit contacts controls GABAA receptor assembly and stoichiometry. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 9124-33. PMID 11717345  0.8
2001 Willeit M, Stastny J, Pirker W, Praschak-Rieder N, Neumeister A, Asenbaum S, Tauscher J, Fuchs K, Sieghart W, Hornik K, Aschauer HN, Brücke T, Kasper S. No evidence for in vivo regulation of midbrain serotonin transporter availability by serotonin transporter promoter gene polymorphism. Biological Psychiatry. 50: 8-12. PMID 11457418 DOI: 10.1016/S0006-3223(00)01123-9  0.8
2001 Sigel E, Baur R, Furtmueller R, Razet R, Dodd RH, Sieghart W. Differential cross talk of ROD compounds with the benzodiazepine binding site. Molecular Pharmacology. 59: 1470-7. PMID 11353808  0.8
2001 Schwarzer C, Berresheim U, Pirker S, Wieselthaler A, Fuchs K, Sieghart W, Sperk G. Distribution of the major gamma-aminobutyric acid(A) receptor subunits in the basal ganglia and associated limbic brain areas of the adult rat. The Journal of Comparative Neurology. 433: 526-49. PMID 11304716 DOI: 10.1002/cne.1158  0.8
2001 Klausberger T, Ehya N, Fuchs K, Fuchs T, Ebert V, Sarto I, Sieghart W. Detection and binding properties of GABA(A) receptor assembly intermediates. The Journal of Biological Chemistry. 276: 16024-32. PMID 11278514 DOI: 10.1074/jbc.M009508200  0.8
2001 Maric D, Liu QY, Maric I, Chaudry S, Chang YH, Smith SV, Sieghart W, Fritschy JM, Barker JL. GABA expression dominates neuronal lineage progression in the embryonic rat neocortex and facilitates neurite outgrowth via GABA(A) autoreceptor/Cl- channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 2343-60. PMID 11264309  0.8
2001 Saha S, Sieghart W, Fritschy JM, McWilliam PN, Batten TF. Gamma-aminobutyric acid receptor (GABA(A)) subunits in rat nucleus tractus solitarii (NTS) revealed by polymerase chain reaction (PCR) and immunohistochemistry. Molecular and Cellular Neurosciences. 17: 241-57. PMID 11161482 DOI: 10.1006/mcne.2000.0919  0.8
2001 Tretter V, Hauer B, Nusser Z, Mihalek RM, Höger H, Homanics GE, Somogyi P, Sieghart W. Targeted disruption of the GABA(A) receptor delta subunit gene leads to an up-regulation of gamma 2 subunit-containing receptors in cerebellar granule cells. The Journal of Biological Chemistry. 276: 10532-8. PMID 11136737 DOI: 10.1074/jbc.M011054200  0.8
2001 Buhr A, Wagner C, Fuchs K, Sieghart W, Sigel E. Two novel residues in M2 of the gamma-aminobutyric acid type A receptor affecting gating by GABA and picrotoxin affinity. The Journal of Biological Chemistry. 276: 7775-81. PMID 11114302 DOI: 10.1074/jbc.M008907200  0.8
2000 Gebhardt C, Leisch F, Schüssler P, Fuchs K, Stompe T, Sieghart W, Hornik K, Kasper S, Aschauer HN. Non-association of dopamine D4 and D2 receptor genes with personality in healthy individuals. Psychiatric Genetics. 10: 131-7. PMID 11204349  0.8
2000 Sieghart W. Unraveling the function of GABA(A) receptor subtypes. Trends in Pharmacological Sciences. 21: 411-3. PMID 11121567 DOI: 10.1016/S0165-6147(00)01564-9  0.8
2000 Pirker S, Schwarzer C, Wieselthaler A, Sieghart W, Sperk G. GABA(A) receptors: immunocytochemical distribution of 13 subunits in the adult rat brain. Neuroscience. 101: 815-50. PMID 11113332 DOI: 10.1016/S0306-4522(00)00442-5  0.8
2000 Bailer U, Leisch F, Meszaros K, Lenzinger E, Willinger U, Strobl R, Gebhardt C, Gerhard E, Fuchs K, Sieghart W, Kasper S, Hornik K, Aschauer HN. Genome scan for susceptibility loci for schizophrenia. Neuropsychobiology. 42: 175-82. PMID 11096332  0.8
2000 Heiden A, Schüssler P, Itzlinger U, Leisch F, Scharfetter J, Gebhardt C, Fuchs K, Willeit M, Nilsson L, Miller-Reiter E, Stompe T, Meszaros K, Sieghart W, Hornik K, Kasper S, et al. Association studies of candidate genes in bipolar disorders. Neuropsychobiology. 42: 18-21. PMID 11093065  0.8
2000 Do-Rego JL, Mensah-Nyagan GA, Beaujean D, Vaudry D, Sieghart W, Luu-The V, Pelletier G, Vaudry H. gamma-Aminobutyric acid, acting through gamma -aminobutyric acid type A receptors, inhibits the biosynthesis of neurosteroids in the frog hypothalamus. Proceedings of the National Academy of Sciences of the United States of America. 97: 13925-30. PMID 11087816 DOI: 10.1073/pnas.240269897  0.8
2000 Razet R, Thomet U, Furtmüller R, Chiaroni A, Sigel E, Sieghart W, Dodd RH. 5-[1'-(2'-N-Arylsulfonyl-1',2',3',4'-tetrahydroisoquinolyl)]-4, 5-dihydro-2(3H)-furanones: positive allosteric modulators of the GABA(A) receptor with a new mode of action. Journal of Medicinal Chemistry. 43: 4363-6. PMID 11087560 DOI: 10.1021/jm001049i  0.8
2000 Razet R, Thomet U, Furtmüller R, Jursky F, Sigel E, Sieghart W, Dodd RH. Use of bicuculline, a GABA antagonist, as a template for the development of a new class of ligands showing positive allosteric modulation of the GABA(A) receptor. Bioorganic & Medicinal Chemistry Letters. 10: 2579-83. PMID 11086734  0.8
2000 Meszaros K, Lenzinger E, Hornik K, Füreder T, Stompe T, Willinger U, Heiden A, Fathi N, Gerhard E, Fuchs K, Sieghart W, Kasper S, Aschauer HN. Association study of schizophrenia spectrum disorders and dopamine D3 receptor gene: is schizoaffective disorder special? Psychiatry Research. 96: 179-83. PMID 11063791 DOI: 10.1016/S0165-1781(00)00209-2  0.8
2000 Thomet U, Baur R, Razet R, Dodd RH, Furtmüller R, Sieghart W, Sigel E. A novel positive allosteric modulator of the GABA(A) receptor: the action of (+)-ROD188. British Journal of Pharmacology. 131: 843-50. PMID 11030736 DOI: 10.1038/sj.bjp.0703558  0.8
2000 Simonian SX, Skynner MJ, Sieghart W, Essrich C, Luscher B, Herbison AE. Role of the GABA(A) receptor gamma2 subunit in the development of gonadotropin-releasing hormone neurons in vivo. The European Journal of Neuroscience. 12: 3488-96. PMID 11029618 DOI: 10.1046/j.1460-9568.2000.00225.x  0.8
2000 Brandon NJ, Delmas P, Kittler JT, McDonald BJ, Sieghart W, Brown DA, Smart TG, Moss SJ. GABAA receptor phosphorylation and functional modulation in cortical neurons by a protein kinase C-dependent pathway. The Journal of Biological Chemistry. 275: 38856-62. PMID 10978327 DOI: 10.1074/jbc.M004910200  0.8
2000 Uusi-Oukari M, Heikkilä J, Sinkkonen ST, Mäkelä R, Hauer B, Homanics GE, Sieghart W, Wisden W, Korpi ER. Long-range interactions in neuronal gene expression: evidence from gene targeting in the GABA(A) receptor beta2-alpha6-alpha1-gamma2 subunit gene cluster. Molecular and Cellular Neurosciences. 16: 34-41. PMID 10882481 DOI: 10.1006/mcne.2000.0856  0.8
2000 Sassoè-Pognetto M, Panzanelli P, Sieghart W, Fritschy JM. Colocalization of multiple GABA(A) receptor subtypes with gephyrin at postsynaptic sites. The Journal of Comparative Neurology. 420: 481-98. PMID 10805922 DOI: 10.1002/(SICI)1096-9861(20000515)420:4<481::AID-CNE6>3.0.CO;2-5  0.8
2000 Nicoletti D, Ghini AA, Furtmüller R, Sieghart W, Dodd RH, Burton G. Synthesis and GABA(A) receptor activity of 6-oxa-analogs of neurosteroids. Steroids. 65: 349-56. PMID 10802285 DOI: 10.1016/S0039-128X(00)00088-X  0.8
2000 Klausberger T, Fuchs K, Mayer B, Ehya N, Sieghart W. GABA(A) receptor assembly. Identification and structure of gamma(2) sequences forming the intersubunit contacts with alpha(1) and beta(3) subunits. The Journal of Biological Chemistry. 275: 8921-8. PMID 10722739 DOI: 10.1074/jbc.275.12.8921  0.8
2000 Okada M, Onodera K, Van Renterghem C, Sieghart W, Takahashi T. Functional correlation of GABA(A) receptor alpha subunits expression with the properties of IPSCs in the developing thalamus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 2202-8. PMID 10704495  0.8
2000 Louiset E, McKernan R, Sieghart W, Vaudry H. Subunit composition and pharmacological characterization of gamma-aminobutyric acid type A receptors in frog pituitary melanotrophs. Endocrinology. 141: 1083-92. PMID 10698184 DOI: 10.1210/endo.141.3.7397  0.8
2000 Jursky F, Fuchs K, Buhr A, Tretter V, Sigel E, Sieghart W. Identification of amino acid residues of GABA(A) receptor subunits contributing to the formation and affinity of the tert-butylbicyclophosphorothionate binding site. Journal of Neurochemistry. 74: 1310-6. PMID 10693965  0.8
2000 Itzlinger U, Heiden A, Schüssler P, Leisch F, Scharfetter J, Gebhardt C, Fuchs K, Willeit M, Nilsson L, Miller-Reiter E, Stompe T, Meszaros K, Sieghart W, Hornik K, Kasper S, et al. Bipolar disorder: Candidate genes involved in serotonin and dopamine neurotransmission American Journal of Medical Genetics - Neuropsychiatric Genetics. 96: 491-492.  0.8
1999 Scharfetter J, Chaudhry HR, Hornik K, Fuchs K, Sieghart W, Kasper S, Aschauer HN. Dopamine D3 receptor gene polymorphism and response to clozapine in schizophrenic Pakastani patients. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 10: 17-20. PMID 10647091 DOI: 10.1016/S0924-977X(99)00044-9  0.8
1999 Kapitany T, Schindl M, Schindler SD, Hesselmann B, Füreder T, Barnas C, Sieghart W, Kasper S. The citalopram challenge test in patients with major depression and in healthy controls. Psychiatry Research. 88: 75-88. PMID 10622344 DOI: 10.1016/S0165-1781(99)00082-7  0.8
1999 Nusser Z, Sieghart W, Mody I. Differential regulation of synaptic GABAA receptors by cAMP-dependent protein kinase in mouse cerebellar and olfactory bulb neurones. The Journal of Physiology. 521: 421-35. PMID 10581313  0.8
1999 Mihalek RM, Banerjee PK, Korpi ER, Quinlan JJ, Firestone LL, Mi ZP, Lagenaur C, Tretter V, Sieghart W, Anagnostaras SG, Sage JR, Fanselow MS, Guidotti A, Spigelman I, Li Z, et al. Attenuated sensitivity to neuroactive steroids in gamma-aminobutyrate type A receptor delta subunit knockout mice. Proceedings of the National Academy of Sciences of the United States of America. 96: 12905-10. PMID 10536021 DOI: 10.1073/pnas.96.22.12905  0.8
1999 Feucht M, Fuchs K, Pichlbauer E, Hornik K, Scharfetter J, Goessler R, Füreder T, Cvetkovic N, Sieghart W, Kasper S, Aschauer H. Possible association between childhood absence epilepsy and the gene encoding GABRB3. Biological Psychiatry. 46: 997-1002. PMID 10509183 DOI: 10.1016/S0006-3223(99)00039-6  0.8
1999 Gustincich S, Feigenspan A, Sieghart W, Raviola E. Composition of the GABA(A) receptors of retinal dopaminergic neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 7812-22. PMID 10479684  0.8
1999 Lévi S, Chesnoy-Marchais D, Sieghart W, Triller A. Synaptic control of glycine and GABA(A) receptors and gephyrin expression in cultured motoneurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 7434-49. PMID 10460250  0.8
1999 Chen S, Huang X, Zeng XJ, Sieghart W, Tietz EI. Benzodiazepine-mediated regulation of alpha1, alpha2, beta1-3 and gamma2 GABA(A) receptor subunit proteins in the rat brain hippocampus and cortex. Neuroscience. 93: 33-44. PMID 10430468 DOI: 10.1016/S0306-4522(99)00118-9  0.8
1999 Kannenberg K, Schaerer MT, Fuchs K, Sieghart W, Sigel E. A novel serine kinase with specificity for beta3-subunits is tightly associated with GABA(A) receptors. The Journal of Biological Chemistry. 274: 21257-64. PMID 10409683  0.64
1999 Ebert V, Scholze P, Fuchs K, Sieghart W. Identification of subunits mediating clustering of GABA(A) receptors by rapsyn. Neurochemistry International. 34: 453-63. PMID 10397374  0.72
1999 Sieghart W, Fuchs K, Tretter V, Ebert V, Jechlinger M, Höger H, Adamiker D. Structure and subunit composition of GABA(A) receptors. Neurochemistry International. 34: 379-85. PMID 10397365 DOI: 10.1016/S0197-0186(99)00045-5  0.8
1999 Bencsits E, Ebert V, Tretter V, Sieghart W. A significant part of native gamma-aminobutyric AcidA receptors containing alpha4 subunits do not contain gamma or delta subunits. The Journal of Biological Chemistry. 274: 19613-6. PMID 10391897 DOI: 10.1074/jbc.274.28.19613  0.8
1999 Maric D, Maric I, Wen X, Fritschy JM, Sieghart W, Barker JL, Serafini R. GABAA receptor subunit composition and functional properties of Cl- channels with differential sensitivity to zolpidem in embryonic rat hippocampal cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 4921-37. PMID 10366626  0.8
1999 Lenzinger E, Neumeister A, Praschak-Rieder N, Fuchs K, Gerhard E, Willeit M, Sieghart W, Kasper SF, Hornik K, Aschauer HN. Behavioral effects of tryptophan depletion in seasonal affective disorder associated with the serotonin transporter gene? Psychiatry Research. 85: 241-6. PMID 10333377  0.64
1999 Nusser Z, Ahmad Z, Tretter V, Fuchs K, Wisden W, Sieghart W, Somogyi P. Alterations in the expression of GABAA receptor subunits in cerebellar granule cells after the disruption of the alpha6 subunit gene. The European Journal of Neuroscience. 11: 1685-97. PMID 10215922 DOI: 10.1046/j.1460-9568.1999.00581.x  0.8
1999 Kannenberg K, Sieghart W, Reuter H. Clusters of GABAA receptors on cultured hippocampal cells correlate only partially with functional synapses. The European Journal of Neuroscience. 11: 1256-64. PMID 10103120 DOI: 10.1046/j.1460-9568.1999.00533.x  0.8
1999 Tobet SA, Henderson RG, Whiting PJ, Sieghart W. Special relationship of gamma-aminobutyric acid to the ventromedial nucleus of the hypothalamus during embryonic development. The Journal of Comparative Neurology. 405: 88-98. PMID 10022198 DOI: 10.1002/(SICI)1096-9861(19990301)405:1<88::AID-CNE7>3.0.CO;2-0  0.8
1998 Serafini R, Ma W, Maric D, Maric I, Lahjouji F, Sieghart W, Barker JL. Initially expressed early rat embryonic GABA(A) receptor Cl- ion channels exhibit heterogeneous channel properties. The European Journal of Neuroscience. 10: 1771-83. PMID 9751149 DOI: 10.1046/j.1460-9568.1998.00187.x  0.8
1998 Kapitany T, Meszaros K, Lenzinger E, Schindler SD, Barnas C, Fuchs K, Sieghart W, Aschauer HN, Kasper S. Genetic polymorphisms for drug metabolism (CYP2D6) and tardive dyskinesia in schizophrenia. Schizophrenia Research. 32: 101-6. PMID 9713905  0.64
1998 Mitsuyama H, Little KY, Sieghart W, Devaud LL, Morrow AL. GABA(A) receptor alpha1, alpha4, and beta3 subunit mRNA and protein expression in the frontal cortex of human alcoholics. Alcoholism, Clinical and Experimental Research. 22: 815-22. PMID 9660306  0.8
1998 Barnard EA, Skolnick P, Olsen RW, Mohler H, Sieghart W, Biggio G, Braestrup C, Bateson AN, Langer SZ. International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function. Pharmacological Reviews. 50: 291-313. PMID 9647870  0.8
1998 Spurlock G, Williams J, McGuffin P, Aschauer HN, Lenzinger E, Fuchs K, Sieghart WC, Meszaros K, Fathi N, Laurent C, Mallet J, Macciardi F, Pedrini S, Gill M, Hawi Z, et al. European Multicentre Association Study of Schizophrenia: a study of the DRD2 Ser311Cys and DRD3 Ser9Gly polymorphisms. American Journal of Medical Genetics. 81: 24-8. PMID 9514583 DOI: 10.1002/(SICI)1096-8628(19980207)81:1<24::AID-AJMG5>3.0.CO;2-N  0.8
1998 Jechlinger M, Pelz R, Tretter V, Klausberger T, Sieghart W. Subunit composition and quantitative importance of hetero-oligomeric receptors: GABAA receptors containing alpha6 subunits. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 2449-57. PMID 9502805  0.8
1998 Matthews DB, Devaud LL, Fritschy JM, Sieghart W, Morrow AL. Differential regulation of GABA(A) receptor gene expression by ethanol in the rat hippocampus versus cerebral cortex. Journal of Neurochemistry. 70: 1160-6. PMID 9489737  0.8
1998 Nusser Z, Sieghart W, Somogyi P. Segregation of different GABAA receptors to synaptic and extrasynaptic membranes of cerebellar granule cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 1693-703. PMID 9464994  0.8
1997 Köhler D, Härtter S, Fuchs K, Sieghart W, Hiemke C. CYP2D6 genotype and phenotyping by determination of dextromethorphan and metabolites in serum of healthy controls and of patients under psychotropic medication. Pharmacogenetics. 7: 453-61. PMID 9429230  0.64
1997 Schwarzer C, Tsunashima K, Wanzenböck C, Fuchs K, Sieghart W, Sperk G. GABA(A) receptor subunits in the rat hippocampus II: altered distribution in kainic acid-induced temporal lobe epilepsy. Neuroscience. 80: 1001-17. PMID 9284056  0.64
1997 Sperk G, Schwarzer C, Tsunashima K, Fuchs K, Sieghart W. GABA(A) receptor subunits in the rat hippocampus I: immunocytochemical distribution of 13 subunits. Neuroscience. 80: 987-1000. PMID 9284055  0.64
1997 Devaud LL, Fritschy JM, Sieghart W, Morrow AL. Bidirectional alterations of GABA(A) receptor subunit peptide levels in rat cortex during chronic ethanol consumption and withdrawal. Journal of Neurochemistry. 69: 126-30. PMID 9202302  0.8
1997 Maric D, Maric I, Ma W, Lahojuji F, Somogyi R, Wen X, Sieghart W, Fritschy JM, Barker JL. Anatomical gradients in proliferation and differentiation of embryonic rat CNS accessed by buoyant density fractionation: alpha 3, beta 3 and gamma 2 GABAA receptor subunit co-expression by post-mitotic neocortical neurons correlates directly with cell buoyancy. The European Journal of Neuroscience. 9: 507-22. PMID 9104593 DOI: 10.1111/j.1460-9568.1997.tb01628.x  0.8
1997 Tretter V, Ehya N, Fuchs K, Sieghart W. Stoichiometry and assembly of a recombinant GABAA receptor subtype. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 2728-37. PMID 9092594  0.8
1997 Jones A, Korpi ER, McKernan RM, Pelz R, Nusser Z, Mäkelä R, Mellor JR, Pollard S, Bahn S, Stephenson FA, Randall AD, Sieghart W, Somogyi P, Smith AJ, Wisden W. Ligand-gated ion channel subunit partnerships: GABAA receptor alpha6 subunit gene inactivation inhibits delta subunit expression. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 1350-62. PMID 9006978  0.8
1996 Somogyi P, Fritschy JM, Benke D, Roberts JD, Sieghart W. The gamma 2 subunit of the GABAA receptor is concentrated in synaptic junctions containing the alpha 1 and beta 2/3 subunits in hippocampus, cerebellum and globus pallidus. Neuropharmacology. 35: 1425-44. PMID 9014159 DOI: 10.1016/S0028-3908(96)00086-X  0.8
1996 Ebert V, Scholze P, Sieghart W. Extensive heterogeneity of recombinant gamma-aminobutyric acidA receptors expressed in alpha 4 beta 3 gamma 2-transfected human embryonic kidney 293 cells. Neuropharmacology. 35: 1323-30. PMID 9014148  0.72
1996 Meszaros K, Lenzinger E, Füreder T, Hornik K, Willinger U, Stompe T, Heiden AM, Resinger E, Fathi N, Gerhard E, Fuchs K, Miller-Reiter E, Pfersmann V, Sieghart W, Aschauer HN, et al. Schizophrenia and the dopamine-beta-hydroxylase gene: results of a linkage and association study. Psychiatric Genetics. 6: 17-22. PMID 8925253  0.64
1996 Meszaros K, Lenzinger E, Füreder T, Hornik K, Willinger U, Isenberg KE, Todd RD, Cloninger CR, Reich T, Fuchs K, Sieghart W, Aschauer HN. The influence of phenotype on the outcome of linkage analysis of schizophrenia. Schizophrenia Research. 22: 89-90. PMID 8908696  0.64
1996 Nusser Z, Sieghart W, Benke D, Fritschy JM, Somogyi P. Differential synaptic localization of two major gamma-aminobutyric acid type A receptor alpha subunits on hippocampal pyramidal cells. Proceedings of the National Academy of Sciences of the United States of America. 93: 11939-44. PMID 8876241 DOI: 10.1073/pnas.93.21.11939  0.8
1996 Meszaros K, Brücke T, Fuchs K, Gerhard E, Sieghart W, vanDer Meer CH, Aschauer HN. Normal CAG repeats in the Huntington gene in a family with benign familial chorea. Psychiatric Genetics. 6: 91-4. PMID 8840396  0.64
1996 Scholze P, Ebert V, Sieghart W. Affinity of various ligands for GABAA receptors containing alpha 4 beta 3 gamma 2, alpha 4 gamma 2, or alpha 1 beta 3 gamma 2 subunits. European Journal of Pharmacology. 304: 155-62. PMID 8813598  0.72
1996 Zezula J, Slany A, Sieghart W. Interaction of allosteric ligands with GABAA receptors containing one, two, or three different subunits. European Journal of Pharmacology. 301: 207-14. PMID 8773466  0.8
1996 Nusser Z, Sieghart W, Stephenson FA, Somogyi P. The alpha 6 subunit of the GABAA receptor is concentrated in both inhibitory and excitatory synapses on cerebellar granule cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 103-14. PMID 8613776  0.8
1996 Todd AJ, Watt C, Spike RC, Sieghart W. Colocalization of GABA, glycine, and their receptors at synapses in the rat spinal cord. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 974-82. PMID 8558266  0.8
1995 Slany A, Zezula J, Fuchs K, Sieghart W. Allosteric modulation of [3H]flunitrazepam binding to recombinant GABAA receptors. European Journal of Pharmacology. 291: 99-105. PMID 8566181 DOI: 10.1016/0922-4106(95)90130-2  0.8
1995 Zezula J, Karall S, Dodd RH, Sieghart W. [3H]propyl-6-azido-beta-carboline-3-carboxylate: a new photoaffinity label for the GABAA-benzodiazepine receptor. European Journal of Pharmacology. 281: 93-6. PMID 8566124 DOI: 10.1016/0014-2999(95)00284-R  0.8
1995 Fuchs K, Zezula J, Slany A, Sieghart W. Endogenous [3H]flunitrazepam binding in human embryonic kidney cell line 293. European Journal of Pharmacology. 289: 87-95. PMID 7781715 DOI: 10.1016/0922-4106(95)90172-8  0.8
1995 Nusser Z, Roberts JD, Baude A, Richards JG, Sieghart W, Somogyi P. Immunocytochemical localization of the alpha 1 and beta 2/3 subunits of the GABAA receptor in relation to specific GABAergic synapses in the dentate gyrus. The European Journal of Neuroscience. 7: 630-46. PMID 7620614  0.8
1995 Slany A, Zezula J, Tretter V, Sieghart W. Rat beta 3 subunits expressed in human embryonic kidney 293 cells form high affinity [35S]t-butylbicyclophosphorothionate binding sites modulated by several allosteric ligands of gamma-aminobutyric acid type A receptors. Molecular Pharmacology. 48: 385-91. PMID 7565617  0.8
1994 Tögel M, Mossier B, Fuchs K, Sieghart W. gamma-Aminobutyric acidA receptors displaying association of gamma 3-subunits with beta 2/3 and different alpha-subunits exhibit unique pharmacological properties. The Journal of Biological Chemistry. 269: 12993-8. PMID 8175718  0.64
1994 Mossier B, Tögel M, Fuchs K, Sieghart W. Immunoaffinity purification of gamma-aminobutyric acidA (GABAA) receptors containing gamma 1-subunits. Evidence for the presence of a single type of gamma-subunit in GABAA receptors. The Journal of Biological Chemistry. 269: 25777-82. PMID 7929282  0.64
1994 Inglefield JR, Sieghart W, Kellogg CK. Immunohistochemical and neurochemical evidence for GABAA receptor heterogeneity between the hypothalamus and cortex. Journal of Chemical Neuroanatomy. 7: 243-52. PMID 7873096 DOI: 10.1016/0891-0618(94)90016-7  0.8
1993 Sieghart W, Item C, Buchstaller A, Fuchs K, Höger H, Adamiker D. Evidence for the existence of differential O-glycosylated alpha 5-subunits of the gamma-aminobutyric acidA receptor in the rat brain. Journal of Neurochemistry. 60: 93-8. PMID 8380199  0.64
1992 Sieghart W, Fuchs K, Zezula J, Buchstaller A, Zimprich F, Lassmann H. Biochemical, immunological, and pharmacological characterization of GABAA-benzodiazepine receptor subtypes. Advances in Biochemical Psychopharmacology. 47: 155-62. PMID 1324569  0.8
1991 Zimprich F, Zezula J, Sieghart W, Lassmann H. Immunohistochemical localization of the alpha 1, alpha 2 and alpha 3 subunit of the GABAA receptor in the rat brain. Neuroscience Letters. 127: 125-8. PMID 1715535 DOI: 10.1016/0304-3940(91)90910-L  0.8
1991 Buchstaller A, Adamiker D, Fuchs K, Sieghart W. N-deglycosylation and immunological identification indicates the existence of beta-subunit isoforms of the rat GABAA receptor. Febs Letters. 287: 27-30. PMID 1715287  0.64
1991 Zezula J, Fuchs K, Sieghart W. Separation of alpha 1, alpha 2 and alpha 3 subunits of the GABAA-benzodiazepine receptor complex by immunoaffinity chromatography. Brain Research. 563: 325-8. PMID 1664775 DOI: 10.1016/0006-8993(91)91556-G  0.8
1991 Buchstaller A, Fuchs K, Sieghart W. Identification of alpha 1-, alpha 2- and alpha 3-subunit isoforms of the GABAA-benzodiazepine receptor in the rat brain. Neuroscience Letters. 129: 237-41. PMID 1660579  0.64
1991 Zezula J, Sieghart W. Isolation of type I and type II GABAA-benzodiazepine receptors by immunoaffinity chromatography. Febs Letters. 284: 15-8. PMID 1647972 DOI: 10.1016/0014-5793(91)80750-W  0.8
1990 Fuchs K, Adamiker D, Sieghart W. Identification of alpha 2- and alpha 3-subunits of the GABAA-benzodiazepine receptor complex purified from the brains of young rats. Febs Letters. 261: 52-4. PMID 2155135  0.64
1989 Fuchs K, Sieghart W. Evidence for the existence of several different alpha- and beta-subunits of the GABA/benzodiazepine receptor complex from rat brain. Neuroscience Letters. 97: 329-33. PMID 2541384  0.64
1988 Sieghart W, Fuchs K. Modification of the apparent molecular weight of different benzodiazepine binding proteins from rat brain membranes by various endoglycosidases. Neuroscience Letters. 86: 213-8. PMID 2835713  0.64
1988 Fuchs K, Möhler H, Sieghart W. Various proteins from rat brain, specifically and irreversibly labeled by [3H]flunitrazepam, are distinct alpha-subunits of the GABA-benzodiazepine receptor complex. Neuroscience Letters. 90: 314-9. PMID 2458558  0.64
1987 Sieghart W, Eichinger A, Zezula J. Comparison of tryptic peptides of benzodiazepine binding proteins photolabeled with [3H]flunitrazepam or [3H]Ro 15-4513. Journal of Neurochemistry. 48: 1109-14. PMID 3029327  0.8
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