Steven C. Leiser, Ph.D. - Related publications

Synaptic Transmission Lundbeck Research USA 
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 Roberts A, Grafton G, Powell AD, Brock K, Chen C, Xie D, Huang J, Liu S, Cooper AJ, Brady CA, Qureshi O, Stamataki Z, Manning DD, Moore NA, Sargent BJ, et al. CSTI-300; a novel 5-HT receptor partial agonist with potential to treat patients with irritable bowel syndrome or carcinoid syndrome. The Journal of Pharmacology and Experimental Therapeutics. PMID 32102919 DOI: 10.1124/jpet.119.261008   
2020 Emery S, Fieux S, Vidal B, Courault P, Bouvard S, Tourvieille C, Iecker T, Billard T, Zimmer L, Lancelot S. Preclinical validation of [F]2FNQ1P as a specific PET radiotracer of 5-HT receptors in rat, pig, non-human primate and human brain tissue. Nuclear Medicine and Biology. 82: 57-63. PMID 32006785 DOI: 10.1016/j.nucmedbio.2020.01.006   
2020 Abela AR, Browne CJ, Sargin D, Prevot TD, Ji XD, Li Z, Lambe EK, Fletcher PJ. Median raphe serotonin neurons promote anxiety-like behavior via inputs to the dorsal hippocampus. Neuropharmacology. 107985. PMID 32035145 DOI: 10.1016/j.neuropharm.2020.107985   
2020 Ryu Y, Maekawa T, Yoshino D, Sakitani N, Takashima A, Inoue T, Suzurikawa J, Toyohara J, Tago T, Makuuchi M, Fujita N, Sawada K, Murase S, Watanave M, Hirai H, et al. Mechanical Regulation Underlies Effects of Exercise on Serotonin-Induced Signaling in the Prefrontal Cortex Neurons. Iscience. 23: 100874. PMID 32062453 DOI: 10.1016/j.isci.2020.100874   
2020 Shi W, Wang Y, Wu C, Yang F, Zheng W, Wu S, Liu Y, Wang Z, He Y, Shen J. Synthesis and biological investigation of triazolopyridinone derivatives as potential multireceptor atypical antipsychotics. Bioorganic & Medicinal Chemistry Letters. 127027. PMID 32122737 DOI: 10.1016/j.bmcl.2020.127027   
2020 Okumura T, Nozu T, Ishioh M, Igarashi S, Kumei S, Ohhira M. 5-HT receptors but not cannabinoid receptors in the central nervous system mediate levodopa-induced visceral antinociception in conscious rats. Naunyn-Schmiedeberg's Archives of Pharmacology. PMID 32125460 DOI: 10.1007/s00210-020-01842-0   
2020 Cruz-Corchado J, Ooi FK, Das S, Prahlad V. Global Transcriptome Changes That Accompany Alterations in Serotonin Levels in . G3 (Bethesda, Md.). PMID 31996358 DOI: 10.1534/g3.120.401088   
2020 Wróbel MZ, Chodkowski A, Marciniak M, Dawidowski M, Maksymiuk A, Siwek A, Nowak G, Turło J. Synthesis of new 4-butyl-arylpiperazine-3-(1H-indol-3-yl)pyrrolidine-2,5-dione derivatives and evaluation for their 5-HT and D receptor affinity and serotonin transporter inhibition. Bioorganic Chemistry. 97: 103662. PMID 32086055 DOI: 10.1016/j.bioorg.2020.103662   
2020 Wan M, Ding L, Wang D, Han J, Gao P. Serotonin: A Potent Immune Cell Modulator in Autoimmune Diseases. Frontiers in Immunology. 11: 186. PMID 32117308 DOI: 10.3389/fimmu.2020.00186   
2020 Zhang B, Zhao S, Yang D, Wu Y, Xin Y, Cao H, Huang XP, Cai X, Sun W, Ye N, Xu Y, Peng Y, Zhao S, Liu ZJ, Zhong G, et al. A Novel G Protein-Biased and Subtype-Selective Agonist for a G Protein-Coupled Receptor Discovered from Screening Herbal Extracts. Acs Central Science. 6: 213-225. PMID 32123739 DOI: 10.1021/acscentsci.9b01125   
2020 Marques AM, Macena MV, Cardoso AR, Hammes CSO, Pinheiro FML, Castro NG, Neves GA. Effects of combined 5-HT and cannabinoid receptor modulation on a schizophrenia-related prepulse inhibition deficit in mice. Psychopharmacology. PMID 32095916 DOI: 10.1007/s00213-020-05485-0   
2020 Yang Q, Sun S, Liu W, Liu Q, Wang J. Hypoxia training improves hepatic steatosis partly by downregulation of CB1 receptor in obese mice. Biochemical and Biophysical Research Communications. PMID 32122652 DOI: 10.1016/j.bbrc.2020.02.134   
2020 Cong M, Song J, Chen F, Cao C, Wang S. A surrogate analyte-based LC-MS/MS method for the determination of 5-hydroxytryptamine, kynurenine and tryptophan. Bioanalysis. PMID 32026711 DOI: 10.4155/bio-2019-0267   
2020 Ananth M, Bartlett EA, DeLorenzo C, Lin X, Kunkel L, Vadhan NP, Perlman G, Godstrey M, Holzmacher D, Ogden RT, Parsey RV, Huang C. Prediction of lithium treatment response in bipolar depression using 5-HTT and 5-HT PET. European Journal of Nuclear Medicine and Molecular Imaging. PMID 32055965 DOI: 10.1007/s00259-020-04681-6   
2020 Pujol CN, Dupuy V, Séveno M, Runtz L, Bockaert J, Marin P, Chaumont-Dubel S. Dynamic interactions of the 5-HT receptor with protein partners control dendritic tree morphogenesis. Science Signaling. 13. PMID 32047117 DOI: 10.1126/scisignal.aax9520   
2020 Wang X, Daley C, Gakhar V, Lange H, Vardigan JD, Pearson M, Zhou X, Warren L, Miller CO, Belden M, Harvey AJ, Grishin AA, Coles CJ, O'Connor SM, Thomson F, et al. Pharmacological characterization of the novel and selective α7 nicotinic acetylcholine receptor positive allosteric modulator BNC375. The Journal of Pharmacology and Experimental Therapeutics. PMID 32094294 DOI: 10.1124/jpet.119.263483   
2020 Olajide TM, Liu T, Liu H, Weng X. Antioxidant properties of two novel lipophilic derivatives of hydroxytyrosol. Food Chemistry. 315: 126197. PMID 32018079 DOI: 10.1016/j.foodchem.2020.126197   
2020 Wu P, Luo S, Zhou T, Wang R, Qiu X, Yuan P, Yang Y, Han Q, Jiang L. Possible Mechanisms Involved in the Cooccurrence of Oral Lichen Planus and Hashimoto's Thyroiditis. Mediators of Inflammation. 2020: 6309238. PMID 32089646 DOI: 10.1155/2020/6309238   
2020 Pinheiro Sartori D, de Oliveira NF, Valentim JT, da Silva DMA, Serra Vasconcelos A, Maia Oliveira IC, de Castro Chaves R, Cavalcanti Capibaribe VC, de Carvalho AMR, de Oliveira Rebouças M, Macêdo D, Maia Chaves Filho AJ, de França Fonteles MM, Chavez Gutierrez SJ, Barbosa-Filho JM, et al. Involvement of monoaminergic targets in the antidepressant- and anxiolytic-like effects of the synthetic alkamide Riparin IV: elucidation of further mechanisms through pharmacological, neurochemistry and computational approaches. Behavioural Brain Research. 112487. PMID 31987932 DOI: 10.1016/j.bbr.2020.112487   
2020 Xia J, Zhang Q, Wang Y, Luan J, Yang J, Cong R, Wang Z, Song N. Association of NE, leptin and 5-HT with electrophysiological parameters in patients with primary premature ejaculation. Andrology. PMID 32068350 DOI: 10.1111/andr.12773   
2020 Choi W, Moon JH, Kim H. Serotonergic regulation of energy metabolism in peripheral tissues. The Journal of Endocrinology. PMID 32092036 DOI: 10.1530/JOE-19-0546   
2020 Xu W, Liu Y, Cheng X, Huang N, Hou N, Wang H, Han F, Han X, Sun X. Decreased shedding dipeptidyl peptidase 4 from membrane in Hashimoto's thyroiditis. International Immunopharmacology. 81: 106315. PMID 32086131 DOI: 10.1016/j.intimp.2020.106315   
2020 Sherwood AM, Halberstadt AL, Klein AK, McCorvy JD, Kaylo KW, Kargbo RB, Meisenheimer P. Synthesis and Biological Evaluation of Tryptamines Found in Hallucinogenic Mushrooms: Norbaeocystin, Baeocystin, Norpsilocin, and Aeruginascin. Journal of Natural Products. PMID 32077284 DOI: 10.1021/acs.jnatprod.9b01061   
2020 Shen G, Shi WX. Amphetamine promotes cortical Up state: Role of adrenergic receptors. Addiction Biology. e12879. PMID 32003119 DOI: 10.1111/adb.12879   
2020 Arashi H, Sato T, Kobashigawa J, Luikart H, Kobayashi Y, Okada K, Sinha S, Honda Y, Yeung AC, Khush K, Fearon WF. Long-term clinical outcomes with use of an angiotensin-converting enzyme inhibitor early after heart transplantation. American Heart Journal. 222: 30-37. PMID 32007823 DOI: 10.1016/j.ahj.2020.01.003   
2020 Yang D, Peng S, Wang F. Response of Photosynthesis to High Growth Temperature Was Not Related to Leaf Anatomy Plasticity in Rice ( L.). Frontiers in Plant Science. 11: 26. PMID 32117372 DOI: 10.3389/fpls.2020.00026   
2020 Chen J, Xu Y, Fei K, Wang R, He J, Fu L, Shao S, Li K, Zhu K, Zhang W, Wang Z, Yang J. Physiological mechanism underlying the effect of high temperature during anthesis on spikelet-opening of photo-thermo-sensitive genic male sterile rice lines. Scientific Reports. 10: 2210. PMID 32042005 DOI: 10.1038/s41598-020-59183-0   
2020 Lee JA, Levy DA, Patel KG, Brennan E, Oyer SL. Hair transplantation in frontal fibrosing alopecia and lichen planopilaris: A systematic review. The Laryngoscope. PMID 32045028 DOI: 10.1002/lary.28551   
2020 Silva ON, Franco OL, Neves BJ, Morais ÁCB, De Oliveira Neto JR, da Cunha LC, Naves LM, Pedrino GR, Costa EA, Fajemiroye JO. Involvement of the gabaergic, serotonergic and glucocorticoid mechanism in the anxiolytic-like effect of mastoparan-L. Neuropeptides. 102027. PMID 32059939 DOI: 10.1016/j.npep.2020.102027   
2020 De Deurwaerdère P, Bharatiya R, Chagraoui A, Di Giovanni G. Constitutive activity of 5-HT receptors: Factual analysis. Neuropharmacology. 107967. PMID 31958408 DOI: 10.1016/j.neuropharm.2020.107967   
2020 Yuen H, Hung A, Yang AWH, Lenon GB. Mechanisms of Action of Cassiae Semen for Weight Management: A Computational Molecular Docking Study of Serotonin Receptor 5-HT2C. International Journal of Molecular Sciences. 21. PMID 32079105 DOI: 10.3390/ijms21041326   
2020 Olivier JDA, Olivier B. Translational Studies in the Complex Role of Neurotransmitter Systems in Anxiety and Anxiety Disorders. Advances in Experimental Medicine and Biology. 1191: 121-140. PMID 32002926 DOI: 10.1007/978-981-32-9705-0_8   
2020 Ch'ng SS, Walker AJ, McCarthy M, Le TK, Thomas N, Gibbons A, Udawela M, Kusljic S, Dean B, Gogos A. The Impact of Removal of Ovarian Hormones on Cholinergic Muscarinic Receptors: Examining Prepulse Inhibition and Receptor Binding. Brain Sciences. 10. PMID 32079174 DOI: 10.3390/brainsci10020106   
2020 Prospéro-García O, Ruiz Contreras AE, Ortega Gómez A, Herrera-Solís A, Méndez-Díaz M, . Endocannabinoids as Therapeutic Targets. Archives of Medical Research. 50: 518-526. PMID 32028095 DOI: 10.1016/j.arcmed.2019.09.005   
2020 Fisher R, Hikima A, Morris R, Jackson MJ, Rose S, Varney MA, Depoortere R, Newman-Tancredi A. The selective 5-HT receptor agonist, NLX-112, exerts anti-dyskinetic and anti-parkinsonian-like effects in MPTP-treated marmosets. Neuropharmacology. 107997. PMID 32057799 DOI: 10.1016/j.neuropharm.2020.107997   
2020 Nirogi R, Mohammed AR, Shinde AK, Ravella SR, Bogaraju N, Subramanian R, Mekala VR, Palacharla RC, Muddana N, Thentu JB, Bhyrapuneni G, Abraham R, Jasti V. Discovery and Development of 3-(6-Chloropyridine-3-yloxymethyl)-2-azabicyclo[3.1.0]hexane hydrochloride (SUVN-911): A Novel, Potent, Selective and Orally Active Neuronal Nicotinic Acetylcholine α4β2 Receptor Antagonist for the Treatment of Depression. Journal of Medicinal Chemistry. PMID 32026697 DOI: 10.1021/acs.jmedchem.9b00790   
2020 Lipton RB, Lombard L, Ruff DD, Krege JH, Loo LS, Buchanan A, Melby TE, Buse DC. Trajectory of migraine-related disability following long-term treatment with lasmiditan: results of the GLADIATOR study. The Journal of Headache and Pain. 21: 20. PMID 32093628 DOI: 10.1186/s10194-020-01088-4   
2020 Camerini L, Ardais AP, Xavier J, Bastos CR, Oliveira S, Soares MSP, da Silveira de Mattos B, Ávila AA, do Couto CAT, Spanevello RM, Pochmann D, Moritz CEJ, Porciúncula LO, Figueiró F, Kaster MP, et al. Inosine prevents hyperlocomotion in a ketamine-induced model of mania in rats. Brain Research. 146721. PMID 32045593 DOI: 10.1016/j.brainres.2020.146721   
2020 Witkin JM. mGlu2/3 receptor antagonism: A mechanism to induce rapid antidepressant effects without ketamine-associated side-effects. Pharmacology, Biochemistry, and Behavior. 172854. PMID 31954773 DOI: 10.1016/j.pbb.2020.172854   
2020 Yuri T, Kono Y, Fujita T. Transport characteristics of 5-aminosalicylic acid into colonic epithelium: Involvement of sodium-coupled monocarboxylate transporter SMCT1-mediated transport system. Biochemical and Biophysical Research Communications. PMID 32014250 DOI: 10.1016/j.bbrc.2020.01.139   
2020 Olejarz W, Głuszko A, Cyran A, Bednarek-Rajewska K, Proczka R, Smith DF, Ishman SL, Migacz E, Kukwa W. TLRs and RAGE are elevated in carotid plaques from patients with moderate-to-severe obstructive sleep apnea syndrome. Sleep & Breathing = Schlaf & Atmung. PMID 32076951 DOI: 10.1007/s11325-020-02029-w   
2020 Sullivan HJ, Tursi A, Moore K, Campbell A, Floyd C, Wu C. Binding interactions of ergotamine and dihydroergotamine to 5-hydroxytryptamine receptor 1B (5-HT1b) using Molecular Dynamics Simulations and Dynamic Network Analysis. Journal of Chemical Information and Modeling. PMID 32078320 DOI: 10.1021/acs.jcim.9b01082   
2020 Zhang K, Yang C, Chang L, Sakamoto A, Suzuki T, Fujita Y, Qu Y, Wang S, Pu Y, Tan Y, Wang X, Ishima T, Shirayama Y, Hatano M, Tanaka KF, et al. Essential role of microglial transforming growth factor-β1 in antidepressant actions of (R)-ketamine and the novel antidepressant TGF-β1. Translational Psychiatry. 10: 32. PMID 32066676 DOI: 10.1038/s41398-020-0733-x   
2020 Timperley CM, Bird M, Gore SJ, Lindsay CD, Rice H, Tattersall JEH, Whitmore CL, Green AC. 3-Quinuclidinyl-α-methoxydiphenylacetate: a multi-targeted ligand with antimuscarinic and antinicotinic effects designed for the treatment of anticholinesterase poisoning. Toxicology Letters. PMID 32017982 DOI: 10.1016/j.toxlet.2020.01.027   
2020 Shabaan MA, Kamal AM, Faggal SI, Elsahar AE, Mohamed KO. Synthesis and biological evaluation of pyrazolone analogues as potential anti-inflammatory agents targeting cyclooxygenases and 5-lipoxygenase. Archiv Der Pharmazie. e1900308. PMID 32031284 DOI: 10.1002/ardp.201900308   
2020 Gulsevin A, Papke RL, Horenstein N. In silico modeling of the α7 nicotinic acetylcholine receptor: new pharmacological challenges associated with multiple modes of signaling. Mini Reviews in Medicinal Chemistry. PMID 32000651 DOI: 10.2174/1389557520666200130105256   
2020 Xu G, Chang XF, Gu GX, Jia WX, Guo L, Huang J, Ye GY. Molecular and pharmacological characterization of a β-adrenergic-like octopamine receptor from the green rice leafhopper Nephotettix cincticeps. Insect Biochemistry and Molecular Biology. 103337. PMID 32109588 DOI: 10.1016/j.ibmb.2020.103337   
2020 Hone AJ, Rueda-Ruzafa L, Gordon TJ, Gajewiak J, Christensen S, Dyhring T, Albillos A, McIntosh JM. Expression of α3β2β4 nicotinic acetylcholine receptors by rat adrenal chromaffin cells determined using novel conopeptide antagonists. Journal of Neurochemistry. e14966. PMID 31967330 DOI: 10.1111/jnc.14966   
2020 Bradley SJ, Molloy C, Valuskova P, Dwomoh L, Scarpa M, Rossi M, Finlayson L, Svensson KA, Chernet E, Barth VN, Gherbi K, Sykes DA, Wilson CA, Mistry R, Sexton PM, et al. Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs. Nature Chemical Biology. 16: 240-249. PMID 32080630 DOI: 10.1038/s41589-019-0453-9   
2020 Azam S, Haque ME, Jakaria M, Jo SH, Kim IS, Choi DK. G-Protein-Coupled Receptors in CNS: A Potential Therapeutic Target for Intervention in Neurodegenerative Disorders and Associated Cognitive Deficits. Cells. 9. PMID 32102186 DOI: 10.3390/cells9020506