Edward R. Perl, M.D. - Publications

Affiliations: 
Cell & Molecular Physiology University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Neural Processing of Somatic Sensation

106 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2012 Perl E. Afferent units and somatic sensation Pain. 153: 1783-1784. PMID 22835834 DOI: 10.1016/j.pain.2012.06.013  1
2011 Perl ER. Pain mechanisms: a commentary on concepts and issues. Progress in Neurobiology. 94: 20-38. PMID 21419824 DOI: 10.1016/j.pneurobio.2011.03.001  1
2011 Pribisko AL, Perl ER. Use of a near-infrared diode laser to activate mouse cutaneous nociceptors in vitro. Journal of Neuroscience Methods. 194: 235-41. PMID 20970454 DOI: 10.1016/j.jneumeth.2010.10.013  1
2010 Zheng J, Lu Y, Perl ER. Inhibitory neurones of the spinal substantia gelatinosa mediate interaction of signals from primary afferents. The Journal of Physiology. 588: 2065-75. PMID 20403977 DOI: 10.1113/jphysiol.2010.188052  1
2007 Lu Y, Perl ER. Selective action of noradrenaline and serotonin on neurones of the spinal superficial dorsal horn in the rat. The Journal of Physiology. 582: 127-36. PMID 17463043 DOI: 10.1113/jphysiol.2007.131565  1
2007 Perl ER. Ideas about pain, a historical view. Nature Reviews. Neuroscience. 8: 71-80. PMID 17180164 DOI: 10.1038/nrn2042  1
2005 Hantman AW, Perl ER. Molecular and genetic features of a labeled class of spinal substantia gelatinosa neurons in a transgenic mouse. The Journal of Comparative Neurology. 492: 90-100. PMID 16175558 DOI: 10.1002/cne.20709  1
2005 Lu Y, Perl ER. Modular organization of excitatory circuits between neurons of the spinal superficial dorsal horn (laminae I and II). The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 3900-7. PMID 15829642 DOI: 10.1523/JNEUROSCI.0102-05.2005  1
2004 Perl ER. Current approaches to pathological pain. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 26: 454-6. PMID 15057943 DOI: 10.1002/bies.20011  1
2004 Hantman AW, van den Pol AN, Perl ER. Morphological and physiological features of a set of spinal substantia gelatinosa neurons defined by green fluorescent protein expression. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 836-42. PMID 14749428 DOI: 10.1523/JNEUROSCI.4221-03.2004  1
2003 Lu Y, Perl ER. A specific inhibitory pathway between substantia gelatinosa neurons receiving direct C-fiber input. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 8752-8. PMID 14507975  1
2003 Light AR, Perl ER. Unmyelinated afferent fibers are not only for pain anymore. The Journal of Comparative Neurology. 461: 137-9. PMID 12724832 DOI: 10.1002/cne.10691  1
2002 Lawson SN, Crepps B, Perl ER. Calcitonin gene-related peptide immunoreactivity and afferent receptive properties of dorsal root ganglion neurones in guinea-pigs. The Journal of Physiology. 540: 989-1002. PMID 11986384 DOI: 10.1113/jphysiol.2001.013086  1
2002 Grudt TJ, Perl ER. Correlations between neuronal morphology and electrophysiological features in the rodent superficial dorsal horn. The Journal of Physiology. 540: 189-207. PMID 11927679 DOI: 10.1113/jphysiol.2001.012890  1
2002 Grudt TJ, van den Pol AN, Perl ER. Hypocretin-2 (orexin-B) modulation of superficial dorsal horn activity in rat. The Journal of Physiology. 538: 517-25. PMID 11790816 DOI: 10.1113/jphysiol.2001.013120  1
2000 Shea VK, Cai R, Crepps B, Mason JL, Perl ER. Sensory fibers of the pelvic nerve innervating the Rat's urinary bladder. Journal of Neurophysiology. 84: 1924-33. PMID 11024085  1
1999 Perl ER. Causalgia, pathological pain, and adrenergic receptors. Proceedings of the National Academy of Sciences of the United States of America. 96: 7664-7. PMID 10393877 DOI: 10.1073/pnas.96.14.7664  1
1999 Wood JN, Perl ER. Pain. Current Opinion in Genetics & Development. 9: 328-32. PMID 10377285 DOI: 10.1016/S0959-437X(99)80049-5  1
1999 Birder LA, Perl ER. Expression of alpha2-adrenergic receptors in rat primary afferent neurones after peripheral nerve injury or inflammation. The Journal of Physiology. 515: 533-42. PMID 10050019  1
1999 Birder LA, Perl ER. Expression of α2-adrenergic receptors in rat primary afferent neurones after peripheral nerve injury or inflammation Journal of Physiology. 515: 533-542.  1
1998 Perl ER. Getting a line on pain: is it mediated by dedicated pathways? Nature Neuroscience. 1: 177-8. PMID 10195139 DOI: 10.1038/624  1
1998 Bao J, Li JJ, Perl ER. Differences in Ca2+ channels governing generation of miniature and evoked excitatory synaptic currents in spinal laminae I and II. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 8740-50. PMID 9786981  1
1997 Lawson SN, Crepps BA, Perl ER. Relationship of substance P to afferent characteristics of dorsal root ganglion neurones in guinea-pig. The Journal of Physiology. 505: 177-91. PMID 9409481  1
1997 Borkholder DA, Bao J, Maluf NI, Perl ER, Kovacs GT. Microelectrode arrays for stimulation of neural slice preparations. Journal of Neuroscience Methods. 77: 61-6. PMID 9402558 DOI: 10.1016/S0165-0270(97)00112-X  1
1997 O'Halloran KD, Perl ER. Effects of partial nerve injury on the responses of C-fiber polymodal nociceptors to adrenergic agonists. Brain Research. 759: 233-40. PMID 9221942 DOI: 10.1016/S0006-8993(97)00261-8  1
1996 Perl ER. Cutaneous polymodal receptors: characteristics and plasticity. Progress in Brain Research. 113: 21-37. PMID 9009726  1
1996 Bossut DF, Shea VK, Perl ER. Sympathectomy induces adrenergic excitability of cutaneous C-fiber nociceptors. Journal of Neurophysiology. 75: 514-7. PMID 8822575  1
1995 Li J, Perl ER. ATP modulation of synaptic transmission in the spinal substantia gelatinosa. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 3357-65. PMID 7751915  1
1995 Bossut DF, Perl ER. Effects of nerve injury on sympathetic excitation of A delta mechanical nociceptors. Journal of Neurophysiology. 73: 1721-3. PMID 7643179  1
1994 Perl E. The 1944 Nobel Prize to Erlanger and Gasser The Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 8: 782-783. PMID 8050679  1
1994 Schneider SP, Perl ER. Synaptic mediation from cutaneous mechanical nociceptors. Journal of Neurophysiology. 72: 612-21. PMID 7983523  1
1994 Näström J, Schneider SP, Perl ER. Differential L-glutamate responsiveness among superficial dorsal horn neurons. Journal of Neurophysiology. 72: 2956-65. PMID 7897502  1
1994 Birder LA, Perl ER. Cutaneous sensory receptors. Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society. 11: 534-52. PMID 7860718  1
1994 Li J, Perl ER. Adenosine inhibition of synaptic transmission in the substantia gelatinosa. Journal of Neurophysiology. 72: 1611-21. PMID 7823090  1
1993 Perl ER. Multireceptive neurons and mechanical allodynia Aps Journal. 2: 37-41.  1
1992 Näsström JB, Schneider SP, Perl ER. N-methyl-D-aspartate (NMDA) depolarizes glutamate-insensitive neurones in the superficial dorsal horn. Acta Physiologica Scandinavica. 144: 483-4. PMID 1351332 DOI: 10.1111/j.1748-1716.1992.tb09325.x  1
1991 Sato J, Perl ER. Adrenergic excitation of cutaneous pain receptors induced by peripheral nerve injury. Science (New York, N.Y.). 251: 1608-10. PMID 2011742  1
1991 Perl ER. [559] Recovery and regeneration after spinal neuron injury Journal of Rehabilitation Research and Development. 28: 440.  1
1990 Seroogy KB, Mohapatra NK, Lund PK, Réthelyi M, McGehee DS, Perl ER. Species-specific expression of cholecystokinin messenger RNA in rodent dorsal root ganglia. Brain Research. Molecular Brain Research. 7: 171-6. PMID 2160045 DOI: 10.1016/0169-328X(90)90095-U  1
1990 Cohen RH, Perl ER. Contributions of arachidonic acid derivatives and substance P to the sensitization of cutaneous nociceptors. Journal of Neurophysiology. 64: 457-64. PMID 1698937  1
1989 Rèthelyi M, Light AR, Perl ER. Synaptic ultrastructure of functionally and morphologically characterized neurons of the superficial spinal dorsal horn of cat. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 9: 1846-63. PMID 2723753  1
1988 Bullitt E, Stofer WD, Vierck CJ, Perl ER. Reorganization of primary afferent nerve terminals in the spinal dorsal horn of the primate caudal to anterolateral chordotomy. The Journal of Comparative Neurology. 270: 549-58. PMID 3372746 DOI: 10.1002/cne.902700408  1
1988 Priestley JV, Hynes MA, Han VK, Réthelyi M, Perl ER, Lund PK. In situ hybridization using 32P labelled oligodeoxyribonucleotides for the cellular localisation of mRNA in neuronal and endocrine tissue. An analysis of procedural variables. Histochemistry. 89: 467-79. PMID 2902050 DOI: 10.1007/BF00492604  1
1988 Schneider SP, Perl ER. Comparison of primary afferent and glutamate excitation of neurons in the mammalian spinal dorsal horn. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 8: 2062-73. PMID 2898513  1
1988 Cohen RH, Perl ER. Chemical factors in the sensitization of cutaneous nociceptors. Progress in Brain Research. 74: 201-6. PMID 2460899  1
1986 Sugiura Y, Lee CL, Perl ER. Central projections of identified, unmyelinated (C) afferent fibers innervating mammalian skin. Science (New York, N.Y.). 234: 358-61. PMID 3764416  1
1985 Shea VK, Perl ER. Failure of sympathetic stimulation to affect responsiveness of rabbit polymodal nociceptors. Journal of Neurophysiology. 54: 513-9. PMID 4045538  1
1985 Shea VK, Perl ER. Regeneration of cutaneous afferent unmyelinated (C) fibers after transection. Journal of Neurophysiology. 54: 502-12. PMID 4045537  1
1985 Shea VK, Perl ER. Sensory receptors with unmyelinated (C) fibers innervating the skin of the rabbit's ear. Journal of Neurophysiology. 54: 491-501. PMID 4045536  1
1985 Schneider SP, Perl ER. Selective excitation of neurons in the mammalian spinal dorsal horn by aspartate and glutamate in vitro: correlation with location and excitatory input. Brain Research. 360: 339-43. PMID 2866826 DOI: 10.1016/0006-8993(85)91251-X  1
1985 Honda CN, Perl ER. Functional and morphological features of neurons in the midline region of the caudal spinal cord of the cat. Brain Research. 340: 285-95. PMID 2411353 DOI: 10.1016/0006-8993(85)90925-4  1
1984 Fyffe RE, Perl ER. Is ATP a central synaptic mediator for certain primary afferent fibers from mammalian skin? Proceedings of the National Academy of Sciences of the United States of America. 81: 6890-3. PMID 6593733  1
1984 Ralston HJ, Light AR, Ralston DD, Perl ER. Morphology and synaptic relationships of physiologically identified low-threshold dorsal root axons stained with intra-axonal horseradish peroxidase in the cat and monkey. Journal of Neurophysiology. 51: 777-92. PMID 6201596  1
1983 Honda CN, Mense S, Perl ER. Neurons in ventrobasal region of cat thalamus selectively responsive to noxious mechanical stimulation. Journal of Neurophysiology. 49: 662-73. PMID 6300352  1
1982 Réthelyi M, Light AR, Perl ER. Synaptic complexes formed by functionally defined primary afferent units with fine myelinated fibers. The Journal of Comparative Neurology. 207: 381-93. PMID 6288776 DOI: 10.1002/cne.902070409  1
1981 Konietzny F, Perl ER, Trevino D, Light A, Hensel H. Sensory experiences in man evoked by intraneural electrical stimulation of intact cutaneous afferent fibers. Experimental Brain Research. 42: 219-22. PMID 7262216 DOI: 10.1007/BF00236910  1
1981 Kruger L, Perl ER, Sedivec MJ. Fine structure of myelinated mechanical nociceptor endings in cat hairy skin. The Journal of Comparative Neurology. 198: 137-54. PMID 7229137 DOI: 10.1002/cne.901980112  1
1980 Guth L, Brewer CR, Collins WF, Goldberger ME, Perl ER. Criteria for evaluating spinal cord regeneration experiments. Experimental Neurology. 69: 1-3. PMID 7389842 DOI: 10.1016/0014-4886(80)90138-7  1
1980 Perl ER. Afferent basis of nociception and pain: evidence from the characteristics of sensory receptors and their projections to the spinal dorsal horn. Research Publications - Association For Research in Nervous and Mental Disease. 58: 19-45. PMID 6988920  1
1980 Guth L, Brewer CR, Collins WF, Goldberger ME, Perl ER. Criteria for evaluating spinal cord regeneration experiments. Surgical Neurology. 14: 392. PMID 6893764  1
1979 Light AR, Trevino DL, Perl ER. Morphological features of functionally defined neurons in the marginal zone and substantia gelatinosa of the spinal dorsal horn. The Journal of Comparative Neurology. 186: 151-71. PMID 447881 DOI: 10.1002/cne.901860204  1
1979 Light AR, Perl ER. Reexamination of the dorsal root projection to the spinal dorsal horn including observations on the differential termination of coarse and fine fibers. The Journal of Comparative Neurology. 186: 117-31. PMID 447880 DOI: 10.1002/cne.901860202  1
1979 Light AR, Perl ER. Spinal termination of functionally identified primary afferent neurons with slowly conducting myelinated fibers. The Journal of Comparative Neurology. 186: 133-50. PMID 109477 DOI: 10.1002/cne.901860203  1
1979 Réthelyi M, Trevino DL, Perl ER. Distribution of primary afferent fibers within the sacrococcygeal dorsal horn: an autoradiographic study. The Journal of Comparative Neurology. 185: 603-21. PMID 109476 DOI: 10.1002/cne.901850403  1
1978 Kumazawa T, Perl ER. Excitation of marginal and substantia gelatinosa neurons in the primate spinal cord: indications of their place in dorsal horn functional organization. The Journal of Comparative Neurology. 177: 417-34. PMID 412881 DOI: 10.1002/cne.901770305  1
1977 Light AR, Perl ER. Differential termination of large-diameter and small-diameter primary afferent fibers in the spinal dorsal gray matter as indicated by labeling with horseradish peroxidase. Neuroscience Letters. 6: 59-63. PMID 19605029 DOI: 10.1016/0304-3940(77)90065-9  1
1977 Lynn B, Perl ER. A comparison of four tests for assessing the pain sensitivity of different subjects and test areas. Pain. 3: 353-65. PMID 909713 DOI: 10.1016/0304-3959(77)90065-3  1
1977 Lynn B, Perl ER. Failure of acupuncture to produce localized analgesia. Pain. 3: 339-51. PMID 909712 DOI: 10.1016/0304-3959(77)90064-1  1
1977 Kumazawa T, Perl ER. Primate cutaneous receptors with unmyelinated (C) fibres and their projection to the substantia gelatinosa. Journal De Physiologie. 73: 287-304. PMID 411923  1
1977 Kumazawa T, Perl ER. Primate cutaneous sensory units with unmyelinated (C) afferent fibers. Journal of Neurophysiology. 40: 1325-38. PMID 411895  1
1976 Perl ER, Kumazawa T, Lynn B, Kenins P. Sensitization of high threshold receptors with unmyelinated (C) afferent fibers. Progress in Brain Research. 43: 263-77. PMID 815956 DOI: 10.1016/S0079-6123(08)64359-9  1
1975 Lynn B, Perl ER. Acupuncture analgesia of the skin in relation to the traditional meridian map. The Journal of Physiology. 245: 83P-85P. PMID 1142206  1
1975 Kumazawa T, Perl ER, Burgess PR, Whitehorn D. Ascending projections from marginal zone (Lamina I) neurons of the spinal dorsal horn Journal of Comparative Neurology. 162: 1-11.  1
1971 Bessou P, Burgess PR, Perl ER, Taylor CB. Dynamic properties of mechanoreceptors with unmyelinated (C) fibers. Journal of Neurophysiology. 34: 116-31. PMID 5540574  1
1971 Perl ER. Is pain a specific sensation? Journal of Psychiatric Research. 8: 273-87. PMID 4939377 DOI: 10.1016/0022-3956(71)90024-0  1
1970 Christensen BN, Perl ER. Spinal neurons specifically excited by noxious or thermal stimuli: marginal zone of the dorsal horn. Journal of Neurophysiology. 33: 293-307. PMID 5415075  1
1969 Bessou P, Perl ER. Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli. Journal of Neurophysiology. 32: 1025-43. PMID 5347705  1
1969 Perl ER. Somatic sensation: transfer and processing of information. 1. Peripheral receptors. Electroencephalography and Clinical Neurophysiology. 27: 650-1. PMID 4187259 DOI: 10.1016/0013-4694(69)91209-7  1
1968 Perl ER. Myelinated afferent fibres innervating the primate skin and their response to noxious stimuli. The Journal of Physiology. 197: 593-615. PMID 4969883 DOI: 10.1113/jphysiol.1968.sp008576  1
1968 Perl ER. [Study on sympathetic medullary reflexes]. ActualitéS Neurophysiologiques. 8: 231-50. PMID 4883735  1
1967 Burgess PR, Perl ER. Myelinated afferent fibres responding specifically to noxious stimulation of the skin. The Journal of Physiology. 190: 541-62. PMID 6051786 DOI: 10.1113/jphysiol.1967.sp008227  1
1966 Franz DN, Evans MH, Perl ER. Characteristics of viscerosympathetic reflexes in the spinal cat. The American Journal of Physiology. 211: 1292-8. PMID 5956538  1
1966 Bessou P, Perl ER. Amovement receptor of the small intestine. The Journal of Physiology. 182: 404-26. PMID 5942035 DOI: 10.1113/jphysiol.1966.sp007829  1
1965 Fernandez de Molina A, Kuno M, Perl ER. Antidromically evoked responses from sympathetic preganglionic neurones. The Journal of Physiology. 180: 321-35. PMID 5857112 DOI: 10.1113/jphysiol.1965.sp007705  1
1965 Fernandez de Molina A, Perl ER. Sympathetic activity and the systemic circulation in the spinal cat. The Journal of Physiology. 181: 82-102. PMID 5218181 DOI: 10.1113/jphysiol.1965.sp007747  1
1964 LEITNER JM, PERL ER. RECEPTORS SUPPLIED BY SPINAL NERVES WHICH RESPOND TO CARDIOVASCULAR CHANGES AND ADRENALINE. The Journal of Physiology. 175: 254-74. PMID 14241167 DOI: 10.1113/jphysiol.1964.sp007516  1
1964 BEACHAM WS, PERL ER. CHARACTERISTICS OF A SPINAL SYMPATHETIC REFLEX. The Journal of Physiology. 173: 431-48. PMID 14220262 DOI: 10.1113/jphysiol.1964.sp007466  1
1964 BEACHAM WS, PERL ER. BACKGROUND AND REFLEX DISCHARGE OF SYMPATHETIC PREGANGLIONIC NEURONES IN THE SPINAL CAT. The Journal of Physiology. 172: 400-16. PMID 14199372 DOI: 10.1113/jphysiol.1964.sp007428  1
1964 PERL ER. [STUDIES ON TACTILE SENSITIVITY AND ON VIBRATORY SENSITIVITY]. ActualitéS Neurophysiologiques. 5: 91-110. PMID 14109481  1
1963 PERL ER. Somatosensory mechanisms. Annual Review of Physiology. 25: 459-92. PMID 13942457 DOI: 10.1146/annurev.ph.25.030163.002331  1
1962 PERL ER, WHITLOCK DG, GENTRY JR. Cutaneous projection to second-order neurons of the dorsal column system. Journal of Neurophysiology. 25: 337-58. PMID 14485390  1
1962 PERL ER. A comparison of monosynaptic and polysynaptic reflex responses from individual flexor motoneurones. The Journal of Physiology. 164: 430-49. PMID 13942459 DOI: 10.1113/jphysiol.1962.sp007030  1
1962 PERL ER. Observations on the discharge of flexor motoneurones. The Journal of Physiology. 164: 450-64. PMID 13942458 DOI: 10.1113/jphysiol.1962.sp007031  1
1961 WHITLOCK DG, PERL ER. Thalamic projections of spinothalamic pathways in monkey. Experimental Neurology. 3: 240-55. PMID 13784911  1
1961 PERL ER, WHITLOCK DG. Somatic stimuli exciting spinothalamic projections to thalamic neurons in cat and monkey. Experimental Neurology. 3: 256-96. PMID 13734415  1
1960 KUNO M, PERL ER. Alteration of spinal reflexes by interaction with suprasegmental and dorsal root activity. The Journal of Physiology. 151: 103-22. PMID 14412770 DOI: 10.1113/jphysiol.1960.sp006425  1
1960 HUNT CC, PERL ER. Spinal reflex mechanisms concerned with skeletal muscle. Physiological Reviews. 40: 538-79. PMID 14405411  1
1959 WHITLOCK DG, PERL ER. Afferent projections through ventrolateral funiculi to thalamus of cat. Journal of Neurophysiology. 22: 133-48. PMID 13642090  1
1959 PERL ER. Effects of muscle stretch on excitability of contralateral motoneurones. The Journal of Physiology. 145: 193-203. PMID 13621429 DOI: 10.1113/jphysiol.1959.sp006135  1
1958 PERL ER. Crossed reflex effects evoked by activity in myelinated afferent fibers of muscle. Journal of Neurophysiology. 21: 101-12. PMID 13514501  1
1958 Hisey BL, Perl ER. Electronic integrator with immediate digital output Review of Scientific Instruments. 29: 355-359. DOI: 10.1063/1.1716196  1
1957 PERL ER. Crossed reflexes of cutaneous origin. The American Journal of Physiology. 188: 609-15. PMID 13411266  1
1955 PERL ER, WHITLOCK DG. Potentials evoked in cerebral somatosensory region. Journal of Neurophysiology. 18: 486-501. PMID 13252437  1
1954 PERL ER, CASBY JU. Localization of cerebral electrical activity: the acoustic cortex of cat. Journal of Neurophysiology. 17: 429-42. PMID 13201976  1
1953 PERL ER, GALAMBOS R, GLORIG A. The estimation of hearing threshold by electroencephalography. Electroencephalography and Clinical Neurophysiology. 5: 501-12. PMID 13107596  1
1949 Whitehorn WV, Perl ER. The Use of Change in Capacity to Record Cardiac Volume in Human Subjects. Science (New York, N.Y.). 109: 262-3. PMID 17774884 DOI: 10.1126/science.109.2828.262  1
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