Prafulla Aryal, Ph.D. - Publications

Biology University of California, San Diego, La Jolla, CA 
GIRK channels, addiction, plasticity, G proteins

24 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Wang Q, Corey RA, Hedger G, Aryal P, Grieben M, Nasrallah C, Baronina A, Pike ACW, Shi J, Carpenter EP, Sansom MSP. Lipid Interactions of a Ciliary Membrane TRP Channel: Simulation and Structural Studies of Polycystin-2. Structure (London, England : 1993). PMID 31806353 DOI: 10.1016/J.Str.2019.11.005  0.625
2019 Wang Q, Hedger G, Aryal P, Grieben M, Pike AC, Shi J, Carpenter EP, Sansom MS. Understanding Protein-Lipid Interactions of TRP Channels of the Polycystin Family, through MD Simulations and Structural Studies Biophysical Journal. 116: 534a-535a. DOI: 10.1016/J.Bpj.2018.11.2877  0.673
2019 Cullinan M, Aryal P, Bankston J. Measuring Dynamics of the Acid-Sensing Ion Channel N-Terminus using Transition Metal Ion FRET Biophysical Journal. 116: 35a-36a. DOI: 10.1016/J.Bpj.2018.11.236  0.456
2018 Wang Q, Hedger G, Aryal P, Shi J, Carpenter EP, Sansom MS. A PIP2 Binding Site on a Human TRP Channel: Simulation Studies of PKD2 Biophysical Journal. 114: 397a. DOI: 10.1016/J.Bpj.2017.11.2196  0.639
2017 Nematian-Ardestani E, Jarerattanachat V, Aryal P, Sansom MSP, Tucker SJ. The Effects of Stretch Activation on Ionic Selectivity of the TREK-2 K2P K(+) Channel. Channels (Austin, Tex.). 0. PMID 28723241 DOI: 10.1080/19336950.2017.1356955  0.707
2017 Lacin E, Aryal P, Glaaser IW, Bodhinathan K, Tsai E, Marsh N, Tucker SJ, Sansom MSP, Slesinger PA. Dynamic role of the tether helix in PIP2-dependent gating of a G protein-gated potassium channel. The Journal of General Physiology. PMID 28720589 DOI: 10.1085/Jgp.201711801  0.786
2017 Aryal P, Jarerattanachat V, Clausen MV, Schewe M, McClenaghan C, Argent L, Conrad LJ, Dong YY, Pike AC, Carpenter EP, Baukrowitz T, Sansom MS, Tucker SJ. Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel. Structure (London, England : 1993). PMID 28392258 DOI: 10.1016/J.Str.2017.03.006  0.818
2017 Jarerattanachat V, Clausen MV, Aryal P, Carpenter EP, Sansom MS, Tucker SJ. Structural and Functional Response of a Mechanosensitive K2P K + Channel to Asymmetric Membrane Tension Biophysical Journal. 112: 545a. DOI: 10.1016/J.Bpj.2016.11.2945  0.733
2017 Klesse G, Trick J, Chelvaniththilan S, Aryal P, Wallace J, Tucker S, Sansom MSP. Hydrophobic Gating and Functional Annotation of Ion Channel Structures by Molecular Dynamics Simulations Biophysical Journal. 112. DOI: 10.1016/J.Bpj.2016.11.2233  0.732
2016 Trick JL, Chelvaniththilan S, Klesse G, Aryal P, Wallace EJ, Tucker SJ, Sansom MS. Functional Annotation of Ion Channel Structures by Molecular Simulation. Structure (London, England : 1993). PMID 27866853 DOI: 10.1016/J.Str.2016.10.005  0.758
2016 McClenaghan C, Schewe M, Aryal P, Carpenter EP, Baukrowitz T, Tucker SJ. Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states. The Journal of General Physiology. 147: 497-505. PMID 27241700 DOI: 10.1085/Jgp.201611601  0.813
2016 Aryal P, Jarerattanachat V, Tucker SJ, Sansom MS. Bilayer-Mediated Structural Transitions in the TREK-2 Mechanosensitive K2P Channel Biophysical Journal. 110: 348a. DOI: 10.1016/J.Bpj.2015.11.1874  0.821
2015 Trick JL, Aryal P, Tucker SJ, Sansom MS. Molecular simulation studies of hydrophobic gating in nanopores and ion channels. Biochemical Society Transactions. 43: 146-50. PMID 25849908 DOI: 10.1042/Bst20140256  0.785
2015 Dong YY, Pike AC, Mackenzie A, McClenaghan C, Aryal P, Dong L, Quigley A, Grieben M, Goubin S, Mukhopadhyay S, Ruda GF, Clausen MV, Cao L, Brennan PE, Burgess-Brown NA, et al. K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac. Science (New York, N.Y.). 347: 1256-9. PMID 25766236 DOI: 10.1126/Science.1261512  0.824
2015 Aryal P, Abd-Wahab F, Bucci G, Sansom MS, Tucker SJ. Influence of lipids on the hydrophobic barrier within the pore of the TWIK-1 K2P channel. Channels (Austin, Tex.). 9: 44-9. PMID 25487004 DOI: 10.4161/19336950.2014.981987  0.735
2015 Aryal P, Sansom MS, Tucker SJ. Hydrophobic gating in ion channels. Journal of Molecular Biology. 427: 121-30. PMID 25106689 DOI: 10.1016/J.Jmb.2014.07.030  0.749
2015 Aryal P, Tucker SJ, Sansom MS. Understanding the Dynamics of K2P Channels in Complex Lipid Bilayers Biophysical Journal. 108: 436a-437a. DOI: 10.1016/J.Bpj.2014.11.2384  0.815
2014 Aryal P, Abd-Wahab F, Bucci G, Sansom MS, Tucker SJ. A hydrophobic barrier deep within the inner pore of the TWIK-1 K2P potassium channel. Nature Communications. 5: 4377. PMID 25001086 DOI: 10.1038/Ncomms5377  0.807
2013 Schmidt MR, Aryal P, Tucker SJ, Sansom MS. K2P and Kir K+ Channels in Physiological Bilayers Biophysical Journal. 104: 132a. DOI: 10.1016/J.Bpj.2012.11.754  0.799
2012 Almeida MC, Hew-Butler T, Soriano RN, Rao S, Wang W, Wang J, Tamayo N, Oliveira DL, Nucci TB, Aryal P, Garami A, Bautista D, Gavva NR, Romanovsky AA. Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 2086-99. PMID 22323721 DOI: 10.1523/Jneurosci.5606-11.2012  0.542
2010 Aryal P, Dvir H, Choe S, Slesinger PA. Identification of the Alcohol Activation Site in GIRK Channels Biophysical Journal. 98: 700a. DOI: 10.1016/J.Bpj.2009.12.3840  0.75
2009 Aryal P, Dvir H, Choe S, Slesinger PA. A discrete alcohol pocket involved in GIRK channel activation. Nature Neuroscience. 12: 988-95. PMID 19561601 DOI: 10.1038/Nn.2358  0.714
2009 Aryal P, Dvir H, Choe S, Slesinger PA. Evidence for a Discrete Alcohol Pocket Mediating GIRK Channel Activation Biophysical Journal. 96: 463a. DOI: 10.1016/J.Bpj.2008.12.2387  0.741
2007 Fowler CE, Aryal P, Suen KF, Slesinger PA. Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins. The Journal of Physiology. 580: 51-65. PMID 17185339 DOI: 10.1113/Jphysiol.2006.123216  0.618
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