Beverley A. Orser - Publications

Affiliations: 
University of Toronto, Toronto, ON, Canada 
Area:
GABA, anesthetics, memory, pain, extrasynaptic receptors

153 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Hemmings HC, Riegelhaupt PM, Kelz MB, Solt K, Eckenhoff RG, Orser BA, Goldstein PA. Towards a Comprehensive Understanding of Anesthetic Mechanisms of Action: A Decade of Discovery. Trends in Pharmacological Sciences. PMID 31147199 DOI: 10.1016/j.tips.2019.05.001  0.36
2019 Yu J, Wang DS, Bonin RP, Penna A, Alavian-Ghavanini A, Zurek AA, Rauw G, Baker GB, Orser BA. Gabapentin increases expression of δ subunit-containing GABA receptors. Ebiomedicine. PMID 30878595 DOI: 10.1016/j.ebiom.2019.03.008  1
2019 Orser BA, Wang DS. GABAA Receptor Theory of Perioperative Neurocognitive Disorders. Anesthesiology. 130: 618-619. PMID 30870211 DOI: 10.1097/ALN.0000000000002562  1
2019 Choi S, Avramescu S, Orser BA, Au S. Protocol for a prospective cohort study of assessing postoperative cognitive changes after total hip and knee arthroplasty in the Greater Toronto area. Bmj Open. 9: e024259. PMID 30804030 DOI: 10.1136/bmjopen-2018-024259  0.8
2018 Untereiner A, Abdo S, Bhattacharjee A, Gohil H, Pourasgari F, Ibeh N, Lai M, Batchuluun B, Wong A, Khuu N, Liu Y, Al Rijjal D, Winegarden N, Virtanen C, Orser BA, et al. GABA promotes β-cell proliferation, but does not overcome impaired glucose homeostasis associated with diet-induced obesity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201801397R. PMID 30509117 DOI: 10.1096/fj.201801397R  0.36
2018 Berger M, Schenning KJ, Brown CH, Deiner SG, Whittington RA, Eckenhoff RG, Angst MS, Avramescu S, Bekker A, Brzezinski M, Crosby G, Culley DJ, Eckenhoff M, Eriksson LI, Evered L, ... ... Orser BA, et al. Best Practices for Postoperative Brain Health: Recommendations From the Fifth International Perioperative Neurotoxicity Working Group. Anesthesia and Analgesia. PMID 30303868 DOI: 10.1213/ANE.0000000000003841  1
2018 Wang DS, Kaneshwaran K, Lei G, Mostafa F, Wang J, Lecker I, Avramescu S, Xie YF, Chan NK, Fernandez-Escobar A, Woo J, Chan D, Ramsey AJ, Sivak JM, Lee CJ, ... ... Orser BA, et al. Dexmedetomidine Prevents Excessive γ-Aminobutyric Acid Type A Receptor Function after Anesthesia. Anesthesiology. PMID 29889105 DOI: 10.1097/ALN.0000000000002311  1
2017 Montandon G, Wu H, Liu H, Vu MT, Orser BA, Horner RL. δ-Subunit Containing GABAA Receptors Modulate Respiratory Networks. Scientific Reports. 7: 18105. PMID 29273726 DOI: 10.1038/s41598-017-17379-x  0.6
2017 Wang DSh, Mazer CD, Orser BA. Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery. The New England Journal of Medicine. 376: 1891-2. PMID 28492070  0.68
2017 Lecker I, Wang DS, Kaneshwaran K, Mazer CD, Orser BA. High Concentrations of Tranexamic Acid Inhibit Ionotropic Glutamate Receptors. Anesthesiology. PMID 28475556 DOI: 10.1097/ALN.0000000000001665  1
2017 Avramescu S, Wang DS, Choi S, Orser BA. Preventing delirium: beyond dexmedetomidine. Lancet (London, England). 389: 1009. PMID 28290991 DOI: 10.1016/S0140-6736(17)30661-X  1
2016 Wang DS, Penna A, Orser BA. Ketamine Increases the Function of γ-Aminobutyric Acid Type A Receptors in Hippocampal and Cortical Neurons. Anesthesiology. PMID 27984263 DOI: 10.1097/ALN.0000000000001483  1
2016 Mesbah-Oskui L, Penna A, Orser BA, Horner RL. Reduced expression of α5GABAA receptors elicits autism-like alterations in EEG patterns and sleep-wake behavior. Neurotoxicology and Teratology. PMID 27793660 DOI: 10.1016/j.ntt.2016.10.009  0.6
2016 Perez-Sanchez J, Lorenzo LE, Lecker I, Zurek AA, Labrakakis C, Bridgwater EM, Orser BA, De Koninck Y, Bonin RP. α5GABAA Receptors Mediate Tonic Inhibition in the Spinal Cord Dorsal Horn and Contribute to the Resolution Of Hyperalgesia. Journal of Neuroscience Research. PMID 27792253 DOI: 10.1002/jnr.23981  1
2016 Avramescu S, Wang DS, Horner RL, Orser BA. In Reply. Anesthesiology. 125: 604-605. PMID 27529857 DOI: 10.1097/ALN.0000000000001206  1
2016 Whissell PD, Avramescu S, Wang DS, Orser BA. δGABAA Receptors Are Necessary for Synaptic Plasticity in the Hippocampus: Implications for Memory Behavior. Anesthesia and Analgesia. PMID 27464975 DOI: 10.1213/ANE.0000000000001373  1
2016 Zurek AA, Kemp SW, Aga Z, Walker S, Milenkovic M, Ramsey AJ, Sibille E, Scherer SW, Orser BA. α5GABAA receptor deficiency causes autism-like behaviors. Annals of Clinical and Translational Neurology. 3: 392-8. PMID 27231709 DOI: 10.1002/acn3.303  1
2016 Orser BA, Evers AS, Suresh S, Hertz S. The GAS trial. Lancet (London, England). 387: 1613-4. PMID 27116066 DOI: 10.1016/S0140-6736(16)30199-4  1
2016 Avramescu S, Orser BA. Anesthesia research training: preparing for the future of our speciality. Canadian Journal of Anaesthesia = Journal Canadien D'Anesthesie. PMID 26792281 DOI: 10.1007/s12630-016-0592-3  0.64
2015 Lecker I, Wang DS, Whissell PD, Avramescu S, Mazer CD, Orser BA. Tranexamic acid-associated seizures: Causes and treatment. Annals of Neurology. PMID 26580862 DOI: 10.1002/ana.24558  0.64
2015 Avramescu S, Wang DS, Lecker I, To WT, Penna A, Whissell PD, Mesbah-Oskui L, Horner RL, Orser BA. Inflammation Increases Neuronal Sensitivity to General Anesthetics. Anesthesiology. PMID 26566283 DOI: 10.1097/ALN.0000000000000943  1
2015 Orser BA, U D, Cohen MR. Perioperative Medication Errors: Building Safer Systems. Anesthesiology. PMID 26501388 DOI: 10.1097/ALN.0000000000000905  0.64
2015 Nanji KC, Orser BA. Managing Ebola: Lessons Learned from the SARS Epidemic. Anesthesia and Analgesia. 121: 834-5. PMID 26287305 DOI: 10.1213/ANE.0000000000000748  1
2015 Accardi MV, Brown PM, Miraucourt LS, Orser BA, Bowie D. α6-Containing GABAA Receptors Are the Principal Mediators of Inhibitory Synapse Strengthening by Insulin in Cerebellar Granule Cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 9676-88. PMID 26134650 DOI: 10.1523/JNEUROSCI.0513-15.2015  1
2015 Rappaport BA, Suresh S, Hertz S, Evers AS, Orser BA. Anesthetic neurotoxicity--clinical implications of animal models. The New England Journal of Medicine. 372: 796-7. PMID 25714157 DOI: 10.1056/NEJMp1414786  1
2015 McBain CJ, Kittler J, Luscher B, Mody I, Orser BA. GABAergic signaling in health and disease. Neuropharmacology. 88: 1. PMID 25305324 DOI: 10.1016/j.neuropharm.2014.10.001  1
2015 Whissell PD, Lecker I, Wang DS, Yu J, Orser BA. Altered expression of δGABAA receptors in health and disease. Neuropharmacology. 88: 24-35. PMID 25128850 DOI: 10.1016/j.neuropharm.2014.08.003  1
2015 Zurek AA, Orser BA. Understanding anesthesia-induced memory loss Essentials of Pharmacology For Anesthesia, Pain Medicine, and Critical Care. 847-858. DOI: 10.1007/978-1-4614-8948-1_54  1
2014 Zurek AA, Yu J, Wang DS, Haffey SC, Bridgwater EM, Penna A, Lecker I, Lei G, Chang T, Salter EW, Orser BA. Sustained increase in α5GABAA receptor function impairs memory after anesthesia. The Journal of Clinical Investigation. 124: 5437-41. PMID 25365226 DOI: 10.1172/JCI76669  1
2014 Mesbah-Oskui L, Orser BA, Horner RL. Thalamic δ-subunit containing GABAA receptors promote electrocortical signatures of deep non-REM sleep but do not mediate the effects of etomidate at the thalamus in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 12253-66. PMID 25209268 DOI: 10.1523/JNEUROSCI.0618-14.2014  0.6
2014 Penna A, Wang DS, Yu J, Lecker I, Brown PM, Bowie D, Orser BA. Hydrogen peroxide increases GABAA receptor-mediated tonic current in hippocampal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 10624-34. PMID 25100596 DOI: 10.1523/JNEUROSCI.0335-14.2014  1
2014 Diaz MR, Vollmer CC, Zamudio-Bulcock PA, Vollmer W, Blomquist SL, Morton RA, Everett JC, Zurek AA, Yu J, Orser BA, Valenzuela CF. Repeated intermittent alcohol exposure during the third trimester-equivalent increases expression of the GABA(A) receptor δ subunit in cerebellar granule neurons and delays motor development in rats. Neuropharmacology. 79: 262-74. PMID 24316160 DOI: 10.1016/j.neuropharm.2013.11.020  1
2013 Whissell PD, Eng D, Lecker I, Martin LJ, Wang DS, Orser BA. Acutely increasing δGABA(A) receptor activity impairs memory and inhibits synaptic plasticity in the hippocampus. Frontiers in Neural Circuits. 7: 146. PMID 24062648 DOI: 10.3389/fncir.2013.00146  1
2013 Jevtovic-Todorovic V, Absalom AR, Blomgren K, Brambrink A, Crosby G, Culley DJ, Fiskum G, Giffard RG, Herold KF, Loepke AW, Ma D, Orser BA, Planel E, Slikker W, Soriano SG, et al. Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar. British Journal of Anaesthesia. 111: 143-51. PMID 23722106 DOI: 10.1093/bja/aet177  1
2013 Whissell PD, Rosenzweig S, Lecker I, Wang DS, Wojtowicz JM, Orser BA. γ-aminobutyric acid type A receptors that contain the δ subunit promote memory and neurogenesis in the dentate gyrus. Annals of Neurology. 74: 611-21. PMID 23686887 DOI: 10.1002/ana.23941  1
2013 Lecker I, Yin Y, Wang DS, Orser BA. Potentiation of GABAA receptor activity by volatile anaesthetics is reduced by α5GABAA receptor-preferring inverse agonists. British Journal of Anaesthesia. 110: i73-81. PMID 23535829 DOI: 10.1093/bja/aet038  1
2013 Bonin RP, Zurek AA, Yu J, Bayliss DA, Orser BA. Hyperpolarization-activated current (In) is reduced in hippocampal neurons from Gabra5-/- mice. Plos One. 8: e58679. PMID 23516534 DOI: 10.1371/journal.pone.0058679  1
2013 Xiang YY, Chen X, Li J, Wang S, Faclier G, Macdonald JF, Hogg JC, Orser BA, Lu WY. Isoflurane regulates atypical type-A γ-aminobutyric acid receptors in alveolar type II epithelial cells. Anesthesiology. 118: 1065-75. PMID 23485993 DOI: 10.1097/ALN.0b013e31828e180e  1
2013 Clarke H, Wijeysundera DN, Bonin RP, Orser B, Englesakis M, Katz J. Pregabalin effective for the prevention of chronic postsurgical pain: really? Reply. Anesthesia and Analgesia. 116: 508-9. PMID 23460947 DOI: 10.1213/ANE.0b013e3182799186  1
2013 Clarke H, Kirkham KR, Orser BA, Katznelson R, Mitsakakis N, Ko R, Snyman A, Ma M, Katz J. Gabapentin reduces preoperative anxiety and pain catastrophizing in highly anxious patients prior to major surgery: a blinded randomized placebo-controlled trial. Canadian Journal of Anaesthesia = Journal Canadien D'AnesthéSie. 60: 432-43. PMID 23377862 DOI: 10.1007/s12630-013-9890-1  1
2013 Orser BA, Hyland S, U D, Sheppard I, Wilson CR. Review article: improving drug safety for patients undergoing anesthesia and surgery. Canadian Journal of Anaesthesia = Journal Canadien D'AnesthéSie. 60: 127-35. PMID 23264011 DOI: 10.1007/s12630-012-9853-y  1
2012 Lecker I, Wang DS, Romaschin AD, Peterson M, Mazer CD, Orser BA. Tranexamic acid concentrations associated with human seizures inhibit glycine receptors. The Journal of Clinical Investigation. 122: 4654-66. PMID 23187124 DOI: 10.1172/JCI63375  1
2012 Wang DS, Zurek AA, Lecker I, Yu J, Abramian AM, Avramescu S, Davies PA, Moss SJ, Lu WY, Orser BA. Memory deficits induced by inflammation are regulated by α5-subunit-containing GABAA receptors. Cell Reports. 2: 488-96. PMID 22999935 DOI: 10.1016/j.celrep.2012.08.022  1
2012 Orser BA. Canadian Anesthesiologists' Society 2011 Royal College lecture: anesthesiology: a profession at a crossroads. Canadian Journal of Anaesthesia = Journal Canadien D'AnesthéSie. 59: 882-8. PMID 22865204 DOI: 10.1007/s12630-012-9749-x  1
2012 Clarke H, Bonin RP, Orser BA, Englesakis M, Wijeysundera DN, Katz J. The prevention of chronic postsurgical pain using gabapentin and pregabalin: a combined systematic review and meta-analysis. Anesthesia and Analgesia. 115: 428-42. PMID 22415535 DOI: 10.1213/ANE.0b013e318249d36e  1
2012 Zurek AA, Bridgwater EM, Orser BA. Inhibition of α5 γ-Aminobutyric acid type A receptors restores recognition memory after general anesthesia. Anesthesia and Analgesia. 114: 845-55. PMID 22383672 DOI: 10.1213/ANE.0b013e31824720da  1
2012 Yang K, Trepanier C, Sidhu B, Xie YF, Li H, Lei G, Salter MW, Orser BA, Nakazawa T, Yamamoto T, Jackson MF, Macdonald JF. Metaplasticity gated through differential regulation of GluN2A versus GluN2B receptors by Src family kinases. The Embo Journal. 31: 805-16. PMID 22187052 DOI: 10.1038/emboj.2011.453  1
2012 Lecker I, Orser BA, Mazer CD. "Seizing" the opportunity to understand antifibrinolytic drugs. Canadian Journal of Anaesthesia = Journal Canadien D'AnesthéSie. 59: 1-5. PMID 22052288 DOI: 10.1007/s12630-011-9621-4  1
2011 Chen X, Li M, Xiong ZG, Orser BA, Macdonald JF, Lu WY. An anti-coagulation agent Futhan preferentially targets GABA(A) receptors in lungepithelia: implication in treating asthma. International Journal of Physiology, Pathophysiology and Pharmacology. 3: 249-56. PMID 22162781  1
2011 Chen X, Whissell P, Orser BA, MacDonald JF. Functional modifications of acid-sensing ion channels by ligand-gated chloride channels. Plos One. 6: e21970. PMID 21789198 DOI: 10.1371/journal.pone.0021970  1
2011 Mashour GA, Orser BA, Avidan MS. Intraoperative awareness: from neurobiology to clinical practice. Anesthesiology. 114: 1218-33. PMID 21464699 DOI: 10.1097/ALN.0b013e31820fc9b6  1
2011 Bonin RP, Labrakakis C, Eng DG, Whissell PD, De Koninck Y, Orser BA. Pharmacological enhancement of δ-subunit-containing GABA(A) receptors that generate a tonic inhibitory conductance in spinal neurons attenuates acute nociception in mice. Pain. 152: 1317-26. PMID 21396779 DOI: 10.1016/j.pain.2011.02.011  1
2011 Lingard L, Regehr G, Cartmill C, Orser B, Espin S, Bohnen J, Reznick R, Baker R, Rotstein L, Doran D. Evaluation of a preoperative team briefing: a new communication routine results in improved clinical practice. Bmj Quality & Safety. 20: 475-82. PMID 21303767 DOI: 10.1136/bmjqs.2009.032326  1
2011 Wang DS, Orser BA. Inhibition of learning and memory by general anesthetics. Canadian Journal of Anaesthesia = Journal Canadien D'AnesthéSie. 58: 167-77. PMID 21181566 DOI: 10.1007/s12630-010-9428-8  1
2011 Miller KW, Orser BA, Roth SH. Mechanisms of anesthesia: past, present, and a glimpse into the future. Canadian Journal of Anaesthesia = Journal Canadien D'AnesthéSie. 58: 131-4, 134-8. PMID 21165729 DOI: 10.1007/s12630-010-9433-y  1
2011 Martin LJ, Zurek AA, Bonin RP, Oh GH, Kim JH, Mount HT, Orser BA. The sedative but not the memory-blocking properties of ethanol are modulated by α5-subunit-containing γ-aminobutyric acid type A receptors. Behavioural Brain Research. 217: 379-85. PMID 21070817 DOI: 10.1016/j.bbr.2010.11.008  1
2011 Li HB, Jackson MF, Yang K, Trepanier C, Salter MW, Orser BA, Macdonald JF. Plasticity of synaptic GluN receptors is required for the Src-dependent induction of long-term potentiation at CA3-CA1 synapses. Hippocampus. 21: 1053-61. PMID 20865743 DOI: 10.1002/hipo.20818  1
2011 Chen X, Li M, Xiong ZG, Orser BA, MacDonald JF, Lu WY. An anti-coagulation agent futhan preferentially targets GABA A receptors in lung epithelia: Implication in treating asthma International Journal of Physiology, Pathophysiology and Pharmacology. 3: 249-256.  1
2010 Chen X, Numata T, Li M, Mori Y, Orser BA, Jackson MF, Xiong ZG, MacDonald JF. The modulation of TRPM7 currents by nafamostat mesilate depends directly upon extracellular concentrations of divalent cations. Molecular Brain. 3: 38. PMID 21122141 DOI: 10.1186/1756-6606-3-38  1
2010 Saab BJ, Maclean AJ, Kanisek M, Zurek AA, Martin LJ, Roder JC, Orser BA. Short-term memory impairment after isoflurane in mice is prevented by the α5 γ-aminobutyric acid type A receptor inverse agonist L-655,708. Anesthesiology. 113: 1061-71. PMID 20966663 DOI: 10.1097/ALN.0b013e3181f56228  1
2010 Chen X, Orser BA, MacDonald JF. Design and screening of ASIC inhibitors based on aromatic diamidines for combating neurological disorders. European Journal of Pharmacology. 648: 15-23. PMID 20854810 DOI: 10.1016/j.ejphar.2010.09.005  1
2010 Martin LJ, Zurek AA, MacDonald JF, Roder JC, Jackson MF, Orser BA. Alpha5GABAA receptor activity sets the threshold for long-term potentiation and constrains hippocampus-dependent memory. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 5269-82. PMID 20392949 DOI: 10.1523/JNEUROSCI.4209-09.2010  1
2010 Clarke H, Kay J, Orser BA, Gollish J, Mitsakakis N, Katz J. Gabapentin does not reduce preoperative anxiety when given prior to total hip arthroplasty. Pain Medicine (Malden, Mass.). 11: 966-71. PMID 20353411 DOI: 10.1111/j.1526-4637.2010.00826.x  1
2010 Chen X, Qiu L, Li M, Dürrnagel S, Orser BA, Xiong ZG, MacDonald JF. Diarylamidines: high potency inhibitors of acid-sensing ion channels. Neuropharmacology. 58: 1045-53. PMID 20114056 DOI: 10.1016/j.neuropharm.2010.01.011  1
2010 Vargas-Caballero M, Martin LJ, Salter MW, Orser BA, Paulsen O. alpha5 Subunit-containing GABA(A) receptors mediate a slowly decaying inhibitory synaptic current in CA1 pyramidal neurons following Schaffer collateral activation. Neuropharmacology. 58: 668-75. PMID 19941877 DOI: 10.1016/j.neuropharm.2009.11.005  1
2009 Li GH, Jackson MF, Orser BA, Macdonald JF. Reciprocal and activity-dependent regulation of surface AMPA and NMDA receptors in cultured neurons. International Journal of Physiology, Pathophysiology and Pharmacology. 2: 47-56. PMID 21383896  1
2009 Martin LJ, Bonin RP, Orser BA. The physiological properties and therapeutic potential of alpha5-GABAA receptors. Biochemical Society Transactions. 37: 1334-7. PMID 19909271 DOI: 10.1042/BST0371334  1
2009 Whyte S, Cartmill C, Gardezi F, Reznick R, Orser BA, Doran D, Lingard L. Uptake of a team briefing in the operating theatre: a Burkean dramatistic analysis. Social Science & Medicine (1982). 69: 1757-66. PMID 19853344 DOI: 10.1016/j.socscimed.2009.09.054  1
2009 Martin LJ, Oh GH, Orser BA. Etomidate targets alpha5 gamma-aminobutyric acid subtype A receptors to regulate synaptic plasticity and memory blockade. Anesthesiology. 111: 1025-35. PMID 19809285 DOI: 10.1097/ALN.0b013e3181bbc961  1
2009 Sun HS, Jackson MF, Martin LJ, Jansen K, Teves L, Cui H, Kiyonaka S, Mori Y, Jones M, Forder JP, Golde TE, Orser BA, Macdonald JF, Tymianski M. Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia. Nature Neuroscience. 12: 1300-7. PMID 19734892 DOI: 10.1038/nn.2395  1
2009 Ju YH, Guzzo A, Chiu MW, Taylor P, Moran MF, Gurd JW, MacDonald JF, Orser BA. Distinct properties of murine alpha 5 gamma-aminobutyric acid type a receptors revealed by biochemical fractionation and mass spectroscopy. Journal of Neuroscience Research. 87: 1737-47. PMID 19156871 DOI: 10.1002/jnr.21991  1
2009 Gardezi F, Lingard L, Espin S, Whyte S, Orser B, Baker GR. Silence, power and communication in the operating room Journal of Advanced Nursing. 65: 1390-1399. DOI: 10.1111/j.1365-2648.2009.04994.x  1
2009 Orser BA. Three editorials - Three historical allusions Anesthesiology. 111: 443. DOI: 10.1097/ALN.0b013e3181ac712d  1
2008 Orser BA, Saper CB. Multimodal anesthesia and systems neuroscience: the new frontier. Anesthesiology. 109: 948-50. PMID 19034087 DOI: 10.1097/ALN.0b013e31818e47fb  1
2008 Burnham GM. Violence-related mortality in Iraq, 2002-2006. The New England Journal of Medicine. 359: 431-2; author reply . PMID 18650523 DOI: 10.1056/NEJMc080419  1
2008 Merali R, Orser BA, Leeksma A, Lingard S, Belo S, Hyland S. Medication safety in the operating room: teaming up to improve patient safety. Healthcare Quarterly (Toronto, Ont.). 11: 54-7. PMID 18382162  1
2008 Orser BA. Depth-of-anesthesia monitor and the frequency of intraoperative awareness. The New England Journal of Medicine. 358: 1189-91. PMID 18337608 DOI: 10.1056/NEJMe0800998  1
2008 Lingard L, Regehr G, Orser B, Reznick R, Baker GR, Doran D, Espin S, Bohnen J, Whyte S. Evaluation of a preoperative checklist and team briefing among surgeons, nurses, and anesthesiologists to reduce failures in communication. Archives of Surgery (Chicago, Ill. : 1960). 143: 12-7; discussion 18. PMID 18209148 DOI: 10.1001/archsurg.2007.21  1
2008 Bonin RP, Orser BA. GABA(A) receptor subtypes underlying general anesthesia. Pharmacology, Biochemistry, and Behavior. 90: 105-12. PMID 18201756 DOI: 10.1016/j.pbb.2007.12.011  1
2008 Orser BA, Mazer CD, Baker AJ. Awareness during anesthesia. Cmaj : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne. 178: 185-8. PMID 18073268 DOI: 10.1503/cmaj.071761  0.68
2008 Whyte S, Lingard L, Espin S, Baker GR, Bohnen J, Orser BA, Doran D, Reznick R, Regehr G. Paradoxical effects of interprofessional briefings on or team performance Cognition, Technology and Work. 10: 287-294. DOI: 10.1007/s10111-007-0086-8  1
2007 Meyer R, Orser BA, Byrick R. Medication error: a leading cause of anesthesia-related morbidity and mortality. Anesthesiology. 107: 1033; author reply 1. PMID 18043078 DOI: 10.1097/01.anes.0000290620.54964.96  1
2007 Wei WL, Sun HS, Olah ME, Sun X, Czerwinska E, Czerwinski W, Mori Y, Orser BA, Xiong ZG, Jackson MF, Tymianski M, MacDonald JF. TRPM7 channels in hippocampal neurons detect levels of extracellular divalent cations. Proceedings of the National Academy of Sciences of the United States of America. 104: 16323-8. PMID 17913893 DOI: 10.1073/pnas.0701149104  1
2007 Bonin RP, Martin LJ, MacDonald JF, Orser BA. Alpha5GABAA receptors regulate the intrinsic excitability of mouse hippocampal pyramidal neurons. Journal of Neurophysiology. 98: 2244-54. PMID 17715197 DOI: 10.1152/jn.00482.2007  1
2007 Orser BA. Lifting the fog around anesthesia. Scientific American. 296: 54-61. PMID 17663225  1
2007 Xiang YY, Wang S, Liu M, Hirota JA, Li J, Ju W, Fan Y, Kelly MM, Ye B, Orser B, O'Byrne PM, Inman MD, Yang X, Lu WY. A GABAergic system in airway epithelium is essential for mucus overproduction in asthma. Nature Medicine. 13: 862-7. PMID 17589520 DOI: 10.1038/nm1604  1
2007 Li J, Zhang N, Ye B, Ju W, Orser B, Fox JE, Wheeler MB, Wang Q, Lu WY. Non-steroidal anti-inflammatory drugs increase insulin release from beta cells by inhibiting ATP-sensitive potassium channels. British Journal of Pharmacology. 151: 483-93. PMID 17435793 DOI: 10.1038/sj.bjp.0707259  1
2007 Caraiscos VB, Bonin RP, Newell JG, Czerwinska E, Macdonald JF, Orser BA. Insulin increases the potency of glycine at ionotropic glycine receptors. Molecular Pharmacology. 71: 1277-87. PMID 17308032 DOI: 10.1124/mol.106.033563  1
2006 Orser BA. Extrasynaptic GABAA receptors are critical targets for sedative-hypnotic drugs. Journal of Clinical Sleep Medicine : Jcsm : Official Publication of the American Academy of Sleep Medicine. 2: S12-8. PMID 17557502  1
2006 Lingard L, Whyte S, Espin S, Baker GR, Orser B, Doran D. Towards safer interprofessional communication: constructing a model of "utility" from preoperative team briefings. Journal of Interprofessional Care. 20: 471-83. PMID 17000473 DOI: 10.1080/13561820600921865  1
2006 Cheng VY, Bonin RP, Chiu MW, Newell JG, MacDonald JF, Orser BA. Gabapentin increases a tonic inhibitory conductance in hippocampal pyramidal neurons. Anesthesiology. 105: 325-33. PMID 16871066 DOI: 10.1097/00000542-200608000-00015  1
2006 Cheng VY, Martin LJ, Elliott EM, Kim JH, Mount HT, Taverna FA, Roder JC, Macdonald JF, Bhambri A, Collinson N, Wafford KA, Orser BA. Alpha5GABAA receptors mediate the amnestic but not sedative-hypnotic effects of the general anesthetic etomidate. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 3713-20. PMID 16597725 DOI: 10.1523/JNEUROSCI.5024-05.2006  1
2006 Orser BA, Dionee C, Hyland S. Drug safety in Canada: 2 steps forward, 1 step back. Cmaj : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne. 174: 66; discussion 66-7. PMID 16389245 DOI: 10.1503/cmaj.1050235  1
2006 Orser BA, Study RE. The structure and function of neurons Foundations of Anesthesia. 221-232. DOI: 10.1016/B978-0-323-03707-5.50025-5  1
2005 Macdonald DS, Weerapura M, Beazely MA, Martin L, Czerwinski W, Roder JC, Orser BA, MacDonald JF. Modulation of NMDA receptors by pituitary adenylate cyclase activating peptide in CA1 neurons requires G alpha q, protein kinase C, and activation of Src. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 11374-84. PMID 16339032 DOI: 10.1523/JNEUROSCI.3871-05.2005  1
2005 Lingard L, Espin S, Rubin B, Whyte S, Colmenares M, Baker GR, Doran D, Grober E, Orser B, Bohnen J, Reznick R. Getting teams to talk: Development and pilot implementation of a checklist to promote interprofessional communication in the OR Quality and Safety in Health Care. 14: 340-346. PMID 16195567 DOI: 10.1136/qshc.2004.012377  1
2005 Hemmings HC, Akabas MH, Goldstein PA, Trudell JR, Orser BA, Harrison NL. Emerging molecular mechanisms of general anesthetic action. Trends in Pharmacological Sciences. 26: 503-10. PMID 16126282 DOI: 10.1016/j.tips.2005.08.006  1
2005 Naik VN, Levine MF, Orser BA. Grow your own: strategies to develop anesthesia researchers. Canadian Journal of Anaesthesia = Journal Canadien D'AnesthéSie. 52: 437. PMID 15814763 DOI: 10.1007/BF03016291  1
2005 Orser BA, Caraiscos VB, Elliott E, Cheng VY, Newell JG, MacDonald JF. Anesthetic sensitivity is reduced in hippocampal pyramidal neurons from GABAA receptor α5 subunit null mutant mice International Congress Series. 1283: 38-42. DOI: 10.1016/j.ics.2005.07.070  1
2005 Orser BA, Caraiscos VB, You-Ten EK, Cheng VY, Newell JG, MacDonald JF. The α5 GABAA receptor subunit confers resistance to isoflurane inhibition International Congress Series. 1283: 189-192. DOI: 10.1016/j.ics.2005.06.085  1
2004 Orser BA, Byrick R. Anesthesia-related medication error: time to take action. Canadian Journal of Anaesthesia = Journal Canadien D'AnesthéSie. 51: 756-60. PMID 15470163 DOI: 10.1007/BF03018447  1
2004 Lingard L, Espin S, Whyte S, Regehr G, Baker GR, Reznick R, Bohnen J, Orser B, Doran D, Grober E. Communication failures in the operating room: An observational classification of recurrent types and effects Quality and Safety in Health Care. 13: 330-334. PMID 15465935 DOI: 10.1136/qshc.2003.008425  1
2004 Caraiscos VB, Newell JG, You-Ten KE, Elliott EM, Rosahl TW, Wafford KA, MacDonald JF, Orser BA. Selective enhancement of tonic GABAergic inhibition in murine hippocampal neurons by low concentrations of the volatile anesthetic isoflurane. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 8454-8. PMID 15456818 DOI: 10.1523/JNEUROSCI.2063-04.2004  1
2004 Xing Y, Sonner J, Laster MJ, Abaigar W, Caraiscos VB, Orser B, Eger EI. Insulin decreases isoflurane minimum alveolar anesthetic concentration in rats independently of an effect on the spinal cord. Anesthesia and Analgesia. 98: 1712-7, table of con. PMID 15155333  1
2004 Caraiscos VB, Elliott EM, You-Ten KE, Cheng VY, Belelli D, Newell JG, Jackson MF, Lambert JJ, Rosahl TW, Wafford KA, MacDonald JF, Orser BA. Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptors. Proceedings of the National Academy of Sciences of the United States of America. 101: 3662-7. PMID 14993607 DOI: 10.1073/pnas.0307231101  1
2003 Lederer W, Benzer A, Doyle DJ, Lamb JD, Chan VWS, Vicente KJ, Kada-Bekhaled K, Hillel G, Cassano A, Orser BA. Programming errors from patient-controlled analgesia [3] Canadian Journal of Anesthesia. 50: 854-857. PMID 14525830  1
2003 Sonner JM, Antognini JF, Dutton RC, Flood P, Gray AT, Harris RA, Homanics GE, Kendig J, Orser B, Raines DE, Rampil IJ, Trudell J, Vissel B, Eger EI. Inhaled anesthetics and immobility: mechanisms, mysteries, and minimum alveolar anesthetic concentration. Anesthesia and Analgesia. 97: 718-40. PMID 12933393  1
2003 Jackson MF, Joo DT, Al-Mahrouki AA, Orser BA, Macdonald JF. Desensitization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors facilitates use-dependent inhibition by pentobarbital. Molecular Pharmacology. 64: 395-406. PMID 12869644 DOI: 10.1124/mol.64.2.395  1
2003 Kotecha SA, Jackson MF, Al-Mahrouki A, Roder JC, Orser BA, MacDonald JF. Co-stimulation of mGluR5 and N-methyl-D-aspartate receptors is required for potentiation of excitatory synaptic transmission in hippocampal neurons. The Journal of Biological Chemistry. 278: 27742-9. PMID 12740378 DOI: 10.1074/jbc.M301946200  1
2003 Vicente KJ, Kada-Bekhaled K, Hillel G, Cassano A, Orser BA. Programming errors contribute to death from patient-controlled analgesia: case report and estimate of probability. Canadian Journal of Anaesthesia = Journal Canadien D'AnesthéSie. 50: 328-32. PMID 12670807 DOI: 10.1007/BF03021027  1
2003 Yeung JY, Canning KJ, Zhu G, Pennefather P, MacDonald JF, Orser BA. Tonically activated GABAA receptors in hippocampal neurons are high-affinity, low-conductance sensors for extracellular GABA. Molecular Pharmacology. 63: 2-8. PMID 12488530 DOI: 10.1124/mol.63.1.2  1
2002 Orser BA, Canning KJ, Macdonald JF. Mechanisms of general anesthesia. Current Opinion in Anaesthesiology. 15: 427-33. PMID 17019234 DOI: 10.1097/00001503-200208000-00004  1
2002 Baker PM, Pennefather PS, Orser BA, Skinner FK. Disruption of coherent oscillations in inhibitory networks with anesthetics: role of GABA(A) receptor desensitization. Journal of Neurophysiology. 88: 2821-33. PMID 12424315 DOI: 10.1152/jn.00052.2002  1
2002 Orser BA, Miller DR. New opportunities for anesthesia research in Canada. Canadian Journal of Anaesthesia = Journal Canadien D'AnesthéSie. 49: 895-9. PMID 12419712 DOI: 10.1007/BF03016870  1
2002 Kotecha SA, Oak JN, Jackson MF, Perez Y, Orser BA, Van Tol HH, MacDonald JF. A D2 class dopamine receptor transactivates a receptor tyrosine kinase to inhibit NMDA receptor transmission. Neuron. 35: 1111-22. PMID 12354400 DOI: 10.1016/S0896-6273(02)00859-0  1
2002 Chun R, Orser BA, Madan M. Platelet glycoprotein IIb/IIIa inhibitors: overview and implications for the anesthesiologist. Anesthesia and Analgesia. 95: 879-88. PMID 12351262  1
2002 Schramm BM, Orser BA. Dystonic reaction to propofol attenuated by benztropine (cogentin). Anesthesia and Analgesia. 94: 1237-40, table of co. PMID 11973196  1
2002 Caraiscos VB, Mihic SJ, MacDonald JF, Orser BA. Tyrosine kinases enhance the function of glycine receptors in rat hippocampal neurons and human alpha(1)beta glycine receptors. The Journal of Physiology. 539: 495-502. PMID 11882681 DOI: 10.1113/jphysiol.2001.013508  1
2001 Naik V, Matsumoto E, Houston P, Hamstra S, Yeung R, Mallon J, Martire T, Zwack RM, Campbell DC, Breen TW, Yip RW, Roy JD, Girard M, Drolet P, Guay J, ... ... Orser BA, et al. Learning fiberoptic intubation on a simple model transfers to the O.R. Canadian Journal of Anaesthesia = Journal Canadien D'Anesthesie. 48: A2-A50. PMID 27688127 DOI: 10.1007/BF03028184  1
2001 Jayasuriya JP, Orser BA. Medication safety in anesthetic practice (multiple letters) [4] Canadian Journal of Anesthesia. 48: 614. PMID 11444463  1
2001 Toong S, Xiong ZG, Zavorin SI, Bai D, Orser BA, Thatcher GR, Reynolds JN, MacDonald JF. Modulation of AMPA receptors by a novel organic nitrate. Canadian Journal of Physiology and Pharmacology. 79: 422-9. PMID 11405246 DOI: 10.1139/cjpp-79-5-422  1
2001 Orser BA, Miller DR. Propofol-benzodiazepine interactions: insights from a "bench to bedside" approach. Canadian Journal of Anaesthesia = Journal Canadien D'AnesthéSie. 48: 431-4. PMID 11394508 DOI: 10.1007/BF03028303  1
2001 Joo DT, Gong D, Sonner JM, Jia Z, MacDonald JF, Eger EI, Orser BA. Blockade of AMPA receptors and volatile anesthetics: reduced anesthetic requirements in GluR2 null mutant mice for loss of the righting reflex and antinociception but not minimum alveolar concentration. Anesthesiology. 94: 478-88. PMID 11374610  1
2001 Lei S, Orser BA, Thatcher GR, Reynolds JN, MacDonald JF. Positive allosteric modulators of AMPA receptors reduce proton-induced receptor desensitization in rat hippocampal neurons. Journal of Neurophysiology. 85: 2030-8. PMID 11353019  1
2001 Iihara K, Joo DT, Henderson J, Sattler R, Taverna FA, Lourensen S, Orser BA, Roder JC, Tymianski M. The influence of glutamate receptor 2 expression on excitotoxicity in Glur2 null mutant mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 2224-39. PMID 11264298  1
2001 Bai D, Zhu G, Pennefather P, Jackson MF, MacDonald JF, Orser BA. Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by gamma-aminobutyric acid(A) receptors in hippocampal neurons. Molecular Pharmacology. 59: 814-24. PMID 11259626  1
2001 Orser BA, Chen RJ, Yee DA. Medication errors in anesthetic practice: a survey of 687 practitioners. Canadian Journal of Anaesthesia = Journal Canadien D'AnesthéSie. 48: 139-46. PMID 11220422 DOI: 10.1007/BF03019726  1
2001 Baker PM, Grigull J, Pennefather PS, Orser BA, Skinner FK. Frequency switches in inhibitory networks with anesthetics Neurocomputing. 38: 467-474. DOI: 10.1016/S0925-2312(01)00385-X  1
2000 Joo DT, Orser BA. Anesthetics and glutamate co-transporters in the central nervous system. Canadian Journal of Anaesthesia = Journal Canadien D'AnesthéSie. 47: 725-9. PMID 10958087  1
2000 Lu WY, Jackson MF, Bai D, Orser BA, MacDonald JF. In CA1 pyramidal neurons of the hippocampus protein kinase C regulates calcium-dependent inactivation of NMDA receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 4452-61. PMID 10844014  1
2000 Joo DT, Orser BA. External compression of a nasotracheal tube due to the displaced bony fragments of multiple LeFort fractures. Anesthesiology. 92: 1830-2. PMID 10839937  1
2000 Lei S, Jackson MF, Jia Z, Roder J, Bai D, Orser BA, MacDonald JF. Cyclic GMP-dependent feedback inhibition of AMPA receptors is independent of PKG. Nature Neuroscience. 3: 559-65. PMID 10816311 DOI: 10.1038/75729  1
1999 Bai D, Pennefather PS, MacDonald JF, Orser BA. The general anesthetic propofol slows deactivation and desensitization of GABA(A) receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 10635-46. PMID 10594047  1
1999 Joo DT, Xiong Z, MacDonald JF, Jia Z, Roder J, Sonner J, Orser BA. Blockade of glutamate receptors and barbiturate anesthesia: increased sensitivity to pentobarbital-induced anesthesia despite reduced inhibition of AMPA receptors in GluR2 null mutant mice. Anesthesiology. 91: 1329-41. PMID 10551584 DOI: 10.1097/00000542-199911000-00025  1
1999 Lei S, Lu WY, Xiong ZG, Orser BA, Valenzuela CF, MacDonald JF. Platelet-derived growth factor receptor-induced feed-forward inhibition of excitatory transmission between hippocampal pyramidal neurons. The Journal of Biological Chemistry. 274: 30617-23. PMID 10521446 DOI: 10.1074/jbc.274.43.30617  1
1999 Jariani M, Orser BA. Missed cuff herniation despite fibreoptic bronchoscopy. Canadian Journal of Anaesthesia = Journal Canadien D'AnesthéSie. 46: 514-5. PMID 10349938 DOI: 10.1007/BF03012964  1
1999 Lu WY, Xiong ZG, Lei S, Orser BA, Dudek E, Browning MD, MacDonald JF. G-protein-coupled receptors act via protein kinase C and Src to regulate NMDA receptors. Nature Neuroscience. 2: 331-8. PMID 10204539 DOI: 10.1038/7243  1
1998 Orser BA, McAdam LC, Roder S, MacDonald JF. General anaesthetics and their effects on GABA(A) receptor desensitization. Toxicology Letters. 100: 217-24. PMID 10049145 DOI: 10.1016/S0378-4274(98)00188-X  1
1998 MacDonald JF, Xiong XG, Lu WY, Raouf R, Orser BA. Modulation of NMDA receptors. Progress in Brain Research. 116: 191-208. PMID 9932378  1
1998 McAdam LC, MacDonald JF, Orser BA. Isobolographic analysis of the interactions between midazolam and propofol at GABA(A) receptors in embryonic mouse neurons. Anesthesiology. 89: 1444-54. PMID 9856719 DOI: 10.1097/00000542-199812000-00022  1
1998 Xiong ZG, Raouf R, Lu WY, Wang LY, Orser BA, Dudek EM, Browning MD, MacDonald JF. Regulation of N-methyl-D-aspartate receptor function by constitutively active protein kinase C. Molecular Pharmacology. 54: 1055-63. PMID 9855634  1
1998 Lu WY, Xiong ZG, Orser BA, MacDonald JF. Multiple sites of action of neomycin, Mg2+ and spermine on the NMDA receptors of rat hippocampal CA1 pyramidal neurones. The Journal of Physiology. 512: 29-46. PMID 9729615 DOI: 10.1111/j.1469-7793.1998.029bf.x  1
1997 Oxorn DC, Ferris LE, Harrington E, Orser BA. The effects of midazolam on propofol-induced anesthesia: propofol dose requirements, mood profiles, and perioperative dreams. Anesthesia and Analgesia. 85: 553-9. PMID 9296408 DOI: 10.1097/00000539-199709000-00013  1
1997 Orser BA, Pennefather PS, MacDonald JF. Multiple mechanisms of ketamine blockade of N-methyl-D-aspartate receptors. Anesthesiology. 86: 903-17. PMID 9105235 DOI: 10.1097/00000542-199704000-00021  1
1996 Chen R, Orser BA. Medication labels: for whose benefit? Canadian Journal of Anaesthesia = Journal Canadien D'AnesthéSie. 43: 194-5. PMID 8825548 DOI: 10.1007/BF03011266  1
1996 Orser BA, MacDonald JF. Reconciling differences between in vitro and in vivo effects of propofol. Anesthesiology. 84: 749-50. PMID 8659808  1
1995 Orser BA, Bertlik M, Wang LY, MacDonald JF. Inhibition by propofol (2,6 di-isopropylphenol) of the N-methyl-D-aspartate subtype of glutamate receptor in cultured hippocampal neurones. British Journal of Pharmacology. 116: 1761-8. PMID 8528557  1
1994 Wang LY, Orser BA, Brautigan DL, MacDonald JF. Regulation of NMDA receptors in cultured hippocampal neurons by protein phosphatases 1 and 2A. Nature. 369: 230-2. PMID 8183343 DOI: 10.1038/369230a0  1
1994 Orser BA, Wang LY, Pennefather PS, MacDonald JF. Propofol modulates activation and desensitization of GABAA receptors in cultured murine hippocampal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 7747-60. PMID 7996209  1
1994 Orser BA, Oxorn DC. An anaesthetic drug error: minimizing the risk. Canadian Journal of Anaesthesia = Journal Canadien D'AnesthéSie. 41: 120-4. PMID 7802751 DOI: 10.1007/BF03009804  1
1994 Orser BA, Oxorn DC, Yee DA. Reply (1) Canadian Journal of Anaesthesia. 41: 870. DOI: 10.1007/BF03011598  1
1992 Orser BA, Wang LY, MacDonald JF. Propofol activates inhibitory chloride current in hippocampal neurons Canadian Journal of Anaesthesia. 39: A12.  1
1991 Orser BA, Bertlik M, Fedorko L, O'Brodovich H. Cation selective channel in fetal alveolar type II epithelium. Biochimica Et Biophysica Acta. 1094: 19-26. PMID 1653022 DOI: 10.1016/0167-4889(91)90021-O  1
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