Isaac Veinbergs, Ph.D. - Related publications

University of California, San Diego, La Jolla, CA 
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 Son Y, Jeong YJ, Shin NR, Oh SJ, Nam KR, Choi HD, Choi JY, Lee HJ. Inhibition of Colony-Stimulating Factor 1 Receptor by PLX3397 Prevents Amyloid Beta Pathology and Rescues Dopaminergic Signaling in Aging 5xFAD Mice. International Journal of Molecular Sciences. 21. PMID 32756440 DOI: 10.3390/ijms21155553   
2020 Sun Y, Huang J, Chen Y, Shang H, Zhang W, Yu J, He L, Xing C, Zhuang C. Direct inhibition of Keap1-Nrf2 Protein-Protein interaction as a potential therapeutic strategy for Alzheimer's disease. Bioorganic Chemistry. 103: 104172. PMID 32890991 DOI: 10.1016/j.bioorg.2020.104172   
2020 Xu Z, Lu W, Miao Y, Li H, Xie X, Zhang F. mRNA profiling reveals the potential mechanism of TIPE2 in attenuating cognitive deficits in APP/PS1 mice. International Immunopharmacology. 87: 106792. PMID 32707494 DOI: 10.1016/j.intimp.2020.106792   
2020 Sohrabi M, Floden AM, Manocha GD, Klug MG, Combs CK. IGF-1R Inhibitor Ameliorates Neuroinflammation in an Alzheimer's Disease Transgenic Mouse Model. Frontiers in Cellular Neuroscience. 14: 200. PMID 32719587 DOI: 10.3389/fncel.2020.00200   
2020 Hunsberger HC, Greenwood BP, Tolstikov V, Narain NR, Kiebish MA, Denny CA. Divergence in the metabolome between natural aging and Alzheimer's disease. Scientific Reports. 10: 12171. PMID 32699218 DOI: 10.1038/s41598-020-68739-z   
2020 Yi JH, Whitcomb DJ, Park SJ, Martinez-Perez C, Barbati SA, Mitchell SJ, Cho K. M1 muscarinic acetylcholine receptor dysfunction in moderate Alzheimer's disease pathology. Brain Communications. 2: fcaa058. PMID 32766549 DOI: 10.1093/braincomms/fcaa058   
2020 Russo-Savage L, Rao VKS, Eipper BA, Mains RE. Role of Kalirin and mouse strain in retention of spatial memory training in an Alzheimer's disease model mouse line. Neurobiology of Aging. 95: 69-80. PMID 32768866 DOI: 10.1016/j.neurobiolaging.2020.07.006   
2020 Chiasseu M, Fesharaki A, Saito T, Saido TC, Strittmatter SM. Gene-environment interaction promotes Alzheimer's risk as revealed by synergy of repeated mild traumatic brain injury and mouse App knock-in. Neurobiology of Disease. 145: 105059. PMID 32858147 DOI: 10.1016/j.nbd.2020.105059   
2020 Khandelwal M, Manglani K, Gupta S, Tiku AB. Gamma radiation improves AD pathogenesis in APP/PS1 mouse model by potentiating insulin sensitivity. Heliyon. 6: e04499. PMID 32775714 DOI: 10.1016/j.heliyon.2020.e04499   
2020 Lee HJ, Woo H, Lee HE, Jeon H, Ryu KY, Nam JH, Jeon SG, Park H, Lee JS, Han KM, Lee SM, Kim J, Kang RJ, Lee YH, Kim JI, et al. The novel DYRK1A inhibitor KVN93 regulates cognitive function, amyloid-beta pathology, and neuroinflammation. Free Radical Biology & Medicine. PMID 32896600 DOI: 10.1016/j.freeradbiomed.2020.08.030   
2020 Michael J, Unger MS, Poupardin R, Schernthaner P, Mrowetz H, Attems J, Aigner L. Microglia depletion diminishes key elements of the leukotriene pathway in the brain of Alzheimer's Disease mice. Acta Neuropathologica Communications. 8: 129. PMID 32771067 DOI: 10.1186/s40478-020-00989-4   
2020 Qin X, Hua J, Lin SJ, Zheng HT, Wang JJ, Li W, Ke JJ, Cai HB. Astragalus polysaccharide alleviates cognitive impairment and β-amyloid accumulation in APP/PS1 mice via Nrf2 pathway. Biochemical and Biophysical Research Communications. PMID 32800555 DOI: 10.1016/j.bbrc.2020.07.122   
2020 Cecarini V, Bonfili L, Gogoi O, Lawrence S, Venanzi FM, Azevedo V, Mancha-Agresti P, Drumond MM, Rossi G, Berardi S, Galosi L, Cuccioloni M, Angeletti M, Suchodolski JS, Pilla R, et al. Neuroprotective effects of p62(SQSTM1)-engineered lactic acid bacteria in Alzheimer's disease: a pre-clinical study. Aging. 12. PMID 32855357 DOI: 10.18632/aging.103900   
2020 Maliszewska-Cyna E, Vecchio LM, Thomason LAM, Oore JJ, Steinman J, Joo IL, Dorr A, McLaurin J, Sled JG, Stefanovic B, Aubert I. The effects of voluntary running on cerebrovascular morphology and spatial short-term memory in a mouse model of amyloidosis. Neuroimage. 117269. PMID 32818618 DOI: 10.1016/j.neuroimage.2020.117269   
2020 Mo M, Jönsson ME, Mathews MA, Johnstone D, Ke YD, Ittner LM, Balleine BW, Furlong TM, Camp AJ. K369I tau mice demonstrate a shift towards striatal neuron burst firing and goal-directed behaviour. Neuroscience. PMID 32949670 DOI: 10.1016/j.neuroscience.2020.09.023   
2020 He YX, Shen QY, Tian JH, Wu Q, Xue Q, Zhang GP, Wei W, Liu YH. Zonisamide Ameliorates Cognitive Impairment by Inhibiting ER Stress in a Mouse Model of Type 2 Diabetes Mellitus. Frontiers in Aging Neuroscience. 12: 192. PMID 32754028 DOI: 10.3389/fnagi.2020.00192   
2020 Szegeczki V, Horváth G, Perényi H, Tamás A, Radák Z, Ábrahám D, Zákány R, Reglodi D, Juhász T. Alzheimer's Disease Mouse as a Model of Testis Degeneration. International Journal of Molecular Sciences. 21. PMID 32785075 DOI: 10.3390/ijms21165726   
2020 King MR, Anderson NJ, Deciu M, Guernsey LS, Cundiff M, Hajizadeh S, Jolivalt CG. Insulin deficiency, but not resistance, exaggerates cognitive deficits in transgenic mice expressing human amyloid and tau proteins. Reversal by Exendin-4 treatment. Journal of Neuroscience Research. PMID 32737929 DOI: 10.1002/jnr.24706   
2020 Vemula PK, Jing Y, Cicolini J, Zhang H, Mockett BG, Abraham WC, Liu P. Altered brain arginine metabolism with age in the APP/PSEN1 mouse model of Alzheimer's disease. Neurochemistry International. 104798. PMID 32711019 DOI: 10.1016/j.neuint.2020.104798   
2020 Qin Y, An D, Xu W, Qi X, Wang X, Chen L, Chen L, Sha S. Estradiol Replacement at the Critical Period Protects Hippocampal Neural Stem Cells to Improve Cognition in APP/PS1 Mice. Frontiers in Aging Neuroscience. 12: 240. PMID 32903757 DOI: 10.3389/fnagi.2020.00240   
2020 Xian YF, Qu C, Liu Y, Ip SP, Yuan QJ, Yang W, Lin ZX. Magnolol Ameliorates Behavioral Impairments and Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease. Oxidative Medicine and Cellular Longevity. 2020: 5920476. PMID 32714487 DOI: 10.1155/2020/5920476   
2020 Ochi S, Iga JI, Funahashi Y, Yoshino Y, Yamazaki K, Kumon H, Mori H, Ozaki Y, Mori T, Ueno SI. Identifying Blood Transcriptome Biomarkers of Alzheimer's Disease Using Transgenic Mice. Molecular Neurobiology. PMID 32816243 DOI: 10.1007/s12035-020-02058-2   
2020 Li J, Zhuang L, Luo X, Liang J, Sun E, He Y. Protection of MCC950 against Alzheimer's disease via inhibiting neuronal pyroptosis in SAMP8 mice. Experimental Brain Research. PMID 32892233 DOI: 10.1007/s00221-020-05916-6   
2020 Mori T, Koyama N, Yokoo T, Segawa T, Maeda M, Sawmiller D, Tan J, Town T. Gallic Acid is a Dual α/β-Secretase Modulator that Reverses Cognitive Impairment and Remediates Pathology in Alzheimer Mice. The Journal of Biological Chemistry. PMID 32913125 DOI: 10.1074/jbc.RA119.012330   
2020 Sarlus H, Codita A, Wang X, Cedazo-Minguez A, Schultzberg M, Oprica M. Chronic airway allergy induces pro-inflammatory responses in the brain of wildtype mice but not 3xTgAD mice. Neuroscience. PMID 32916195 DOI: 10.1016/j.neuroscience.2020.09.005   
2020 Cirrito JR, Wallace CE, Yan P, Davis TA, Gardiner WD, Doherty BM, King D, Yuede CM, Lee JM, Sheline YI. Effect of Escitalopram on Aβ levels and plaque load in an Alzheimer mouse model. Neurology. PMID 32913022 DOI: 10.1212/WNL.0000000000010733   
2020 Xu X, Meng T, Wen Q, Tao M, Wang P, Zhong K, Shen Y. Dynamic changes in vascular size and density in transgenic mice with Alzheimer's disease. Aging. 12. PMID 32908022 DOI: 10.18632/aging.103672   
2020 Fu Y, Yang Y, Shi J, Bishayee K, Lin L, Lin Y, Zhang Y, Ji L, Li C. rhizoma extract ameliorates Alzheimer's pathological syndromes by repairing myelin injury and lowering Tau phosphorylation in mice. Die Pharmazie. 75: 395-400. PMID 32758340 DOI: 10.1691/ph.2020.0492   
2020 Griciuc A, Federico AN, Natasan J, Forte AM, McGinty D, Nguyen H, Volak A, LeRoy S, Gandhi S, Lerner EP, Hudry E, Tanzi RE, Maguire CA. Gene therapy for Alzheimer's Disease targeting CD33 reduces amyloid beta accumulation and neuroinflammation. Human Molecular Genetics. PMID 32803224 DOI: 10.1093/hmg/ddaa179   
2020 Bai Y, Ma X. Chlorzoxazone exhibits neuroprotection against Alzheimer's disease by attenuating neuroinflammation and neurodegeneration in vitro and in vivo. International Immunopharmacology. 88: 106790. PMID 32795892 DOI: 10.1016/j.intimp.2020.106790   
2020 Heckmann BL, Teubner BJW, Boada-Romero E, Tummers B, Guy C, Fitzgerald P, Mayer U, Carding S, Zakharenko SS, Wileman T, Green DR. Noncanonical function of an autophagy protein prevents spontaneous Alzheimer's disease. Science Advances. 6: eabb9036. PMID 32851186 DOI: 10.1126/sciadv.abb9036   
2020 Mezö C, Dokalis N, Mossad O, Staszewski O, Neuber J, Yilmaz B, Schnepf D, de Agüero MG, Ganal-Vonarburg SC, Macpherson AJ, Meyer-Luehmann M, Staeheli P, Blank T, Prinz M, Erny D. Different effects of constitutive and induced microbiota modulation on microglia in a mouse model of Alzheimer's disease. Acta Neuropathologica Communications. 8: 119. PMID 32727612 DOI: 10.1186/s40478-020-00988-5   
2020 Zhou L, Huang JY, Zhang D, Zhao YL. Cognitive improvements and reduction in amyloid plaque deposition by saikosaponin D treatment in a murine model of Alzheimer's disease. Experimental and Therapeutic Medicine. 20: 1082-1090. PMID 32742347 DOI: 10.3892/etm.2020.8760   
2020 Lee SH, Kang J, Ho A, Watanabe H, Bolshakov VY, Shen J. APP Family Regulates Neuronal Excitability and Synaptic Plasticity but Not Neuronal Survival. Neuron. PMID 32891188 DOI: 10.1016/j.neuron.2020.08.011   
2020 Wang HY, Pei Z, Lee KC, Lopez-Brignoni E, Nikolov B, Crowley CA, Marsman MR, Barbier R, Friedmann N, Burns LH. PTI-125 Reduces Biomarkers of Alzheimer's Disease in Patients. The Journal of Prevention of Alzheimer's Disease. 7: 256-264. PMID 32920628 DOI: 10.14283/jpad.2020.6   
2020 Sun W, Zhao J, Li C. Dexmedetomidine Provides Protection Against Hippocampal Neuron Apoptosis and Cognitive Impairment in Mice with Alzheimer's Disease by Mediating the miR-129/YAP1/JAG1 Axis. Molecular Neurobiology. PMID 32839917 DOI: 10.1007/s12035-020-02069-z   
2020 Kim WI, Han JY, Song MK, Park HK, Jo J. Cognitive Function Improvement in Mouse Model of Alzheimer's Disease Following Transcranial Direct Current Stimulation. Brain Sciences. 10. PMID 32806774 DOI: 10.3390/brainsci10080547   
2020 Zhang H, Lin A, Gong P, Chen Y, Ye RD, Qian F, Zhang Y, Yu Y. The chemokine-like receptor 1 deficiency improves cognitive deficits of AD mice and attenuates tau hyperphosphorylation via regulating tau seeding. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 32801154 DOI: 10.1523/JNEUROSCI.0455-20.2020   
2020 Ma R, Kong LH, Qi FJ, He RY, Zheng Q, Lu W, Fu XP. [Effect of electroacupuncture on cyclin-dependent kinase 5 and Tau protein in hippocampus of SAMP8 mice]. Zhen Ci Yan Jiu = Acupuncture Research. 45: 529-34. PMID 32705825 DOI: 10.13702/j.1000-0607.190752   
2020 Lv J, Wang W, Zhu X, Xu X, Yan Q, Lu J, Shi X, Wang Z, Zhou J, Huang X, Wang J, Duan W, Shen X. DW14006 as a direct AMPKα1 activator improves pathology of AD model mice by regulating microglial phagocytosis and neuroinflammation. Brain, Behavior, and Immunity. PMID 32739363 DOI: 10.1016/j.bbi.2020.07.041   
2020 Zhao X, Li S, Gaur U, Zheng W. Artemisinin Improved Neuronal Functions in Alzheimer's Disease Animal Model 3xtg Mice and Neuronal Cells via Stimulating the ERK/CREB Signaling Pathway. Aging and Disease. 11: 801-819. PMID 32765947 DOI: 10.14336/AD.2019.0813   
2020 Duan R, Xue X, Zhang QQ, Wang SY, Gong PY, E Y, Jiang T, Zhang YD. ACE2 activator diminazene aceturate ameliorates Alzheimer's disease-like neuropathology and rescues cognitive impairment in SAMP8 mice. Aging. 12. PMID 32701063 DOI: 10.18632/aging.103544   
2020 van der Hoven J, van Hummel A, Przybyla M, Asih PR, Gajwani M, Feiten AF, Ke YD, Ittner A, van Eersel J, Ittner LM. Contribution of endogenous antibodies to learning deficits and astrocytosis in human P301S mutant tau transgenic mice. Scientific Reports. 10: 13845. PMID 32796905 DOI: 10.1038/s41598-020-70845-x   
2020 Luo W, Ip FCF, Fu G, Cheung K, Tian Y, Hu Y, Sinha A, Cheng EYL, Wu X, Bustos V, Greengard P, Li YM, Sinha SC, Ip NY. A pentacyclic triterpene from targets γ-secretase. Acs Chemical Neuroscience. PMID 32786303 DOI: 10.1021/acschemneuro.0c00389   
2020 Flores J, Noël A, Foveau B, Beauchet O, LeBlanc AC. Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging. Nature Communications. 11: 4571. PMID 32917871 DOI: 10.1038/s41467-020-18405-9   
2020 Li YY, Huang NQ, Feng F, Li Y, Luo XM, Tu L, Qu JQ, Xie YM, Luo Y. Icaritin Improves Memory and Learning Ability by Decreasing BACE-1 Expression and the Bax/Bcl-2 Ratio in Senescence-Accelerated Mouse Prone 8 (SAMP8) Mice. Evidence-Based Complementary and Alternative Medicine : Ecam. 2020: 8963845. PMID 32714426 DOI: 10.1155/2020/8963845   
2020 Huang YY, Fang N, Luo HR, Gao F, Zou Y, Zhou LL, Zeng QP, Fang SS, Xiao F, Zheng Q. RP1, a RAGE antagonist peptide, can improve memory impairment and reduce Aβ plaque load in the APP/PS1 mouse model of Alzheimer's disease. Neuropharmacology. 108304. PMID 32931813 DOI: 10.1016/j.neuropharm.2020.108304   
2020 von Saucken VE, Jay TR, Landreth GE. The effect of amyloid on microglia-neuron interactions before plaque onset occurs independently of TREM2 in a mouse model of Alzheimer's disease. Neurobiology of Disease. 105072. PMID 32890775 DOI: 10.1016/j.nbd.2020.105072   
2020 Xia Y, Wang ZH, Liu P, Edgington-Mitchell L, Liu X, Wang XC, Ye K. TrkB receptor cleavage by delta-secretase abolishes its phosphorylation of APP, aggravating Alzheimer's disease pathologies. Molecular Psychiatry. PMID 32782380 DOI: 10.1038/s41380-020-00863-8   
2020 Stoyanov S, Sun W, Düsedau HP, Cangalaya C, Choi I, Mirzapourdelavar H, Baidoe-Ansah D, Kaushik R, Neumann J, Dunay IR, Dityatev A. Attenuation of the extracellular matrix restores microglial activity during the early stage of amyloidosis. Glia. PMID 32865286 DOI: 10.1002/glia.23894