Leslie A. Crews, Ph.D. - Publications

Affiliations: 
Molecular Pathology University of California, San Diego, La Jolla, CA 

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Year Citation  Score
2019 Jamieson C, Jiang Q, Holm F, Isquith J, Mark A, Mason C, Ma W, Diep RH, Pham J, Reynoso Moreno E, Nasamran CA, Guorong X, Birmingham A, Crews LA, Alexandrov L, et al. Inflammatory Cytokine Responsive Enzymatic Mutagenesis Fuels Myeloproliferative Neoplasm Pre-Leukemia Stem Cell Evolution Blood. 134: 3780-3780. DOI: 10.1182/Blood-2019-131510  0.304
2018 Crews LA, Lazzari E, Mondala PK, Santos ND, Miller A, Pineda G, Jiang Q, Ganesan A, Wu C, Costello C, Minden M, Chiaramonte R, Stewart AK, Jamieson CHM. Abstract 4437: Down-modulation of ADAR1-mediated GLI1 editing alters extracellular and immune response genes in multiple myeloma Cancer Research. 78: 4437-4437. DOI: 10.1158/1538-7445.Am2018-4437  0.307
2017 Lazzari E, Santos ND, Wu C, Leu H, Pineda G, Ali S, Costello C, Minden M, Chiaramonte R, Crews L, Jamieson C. Abstract 3351: Aberrant RNA editing of GLI1 promotes malignant regeneration in multiple myeloma Cancer Research. 77: 3351-3351. DOI: 10.1158/1538-7445.Am2017-3351  0.308
2016 Zipeto MA, Court AC, Sadarangani A, Delos Santos NP, Balaian L, Chun HJ, Pineda G, Morris SR, Mason CN, Geron I, Barrett C, Goff DJ, Wall R, Pellecchia M, Minden M, ... ... Crews LA, et al. ADAR1 Activation Drives Leukemia Stem Cell Self-Renewal by Impairing Let-7 Biogenesis. Cell Stem Cell. PMID 27292188 DOI: 10.1016/J.Stem.2016.05.004  0.314
2016 Lazzari E, Crews LA, Wu C, Leu H, Ali S, Chiaramonte R, Minden M, Costello C, Jamieson CHM. Abstract 2414: ADAR1-dependent RNA editing is a mechanism of therapeutic resistance in human plasma cell malignancies Cancer Research. 76: 2414-2414. DOI: 10.1158/1538-7445.Am2016-2414  0.314
2015 Fields JA, Dumaop W, Crews L, Adame A, Spencer B, Metcalf J, He J, Rockenstein E, Masliah E. Mechanisms of HIV-1 Tat neurotoxicity via CDK5 translocation and hyper-activation: role in HIV-associated neurocognitive disorders. Current Hiv Research. 13: 43-54. PMID 25760044 DOI: 10.2174/1570162X13666150311164201  0.49
2015 Crews LA, Balaian L, Leu H, Delos Santos N, Court AC, Sadarangani A, Zipeto MA, La Clair JJ, Villa R, Morris S, Storb RF, Kulidjian A, Ball ED, Burkart MD, Jamieson C. RNA Splicing Modulation Impairs Acute Myeloid Leukemia Stem Cell Maintenance Blood. 126: 567-567. DOI: 10.1182/Blood.V126.23.567.567  0.328
2015 Lazzari E, Crews LA, Wu C, Leu H, Chiaramonte R, Minden MD, Costello CL, Jamieson C. Targeting Cancer Stem Cell Survival in Plasma Cell Leukemia with a Pan-BCL2 Inhibitor Blood. 126: 5351-5351. DOI: 10.1182/Blood.V126.23.5351.5351  0.302
2015 Zipeto MA, Court Recart A, Delos Santos N, Jiang Q, Crews LA, Jamieson CH. Inflammatory Cytokine-Responsive ADAR1 Impairs Let-7 Biogenesis and Promotes Leukemia Stem Cell Generation Blood. 126: 4014-4014. DOI: 10.1182/Blood.V126.23.4014.4014  0.3
2014 Wrasidlo W, Crews LA, Tsigelny IF, Stocking E, Kouznetsova VL, Price D, Paulino A, Gonzales T, Overk CR, Patrick C, Rockenstein E, Masliah E. Neuroprotective effects of the anti-cancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders. British Journal of Pharmacology. 171: 5757-73. PMID 25117211 DOI: 10.1111/Bph.12875  0.434
2014 Zipeto MA, Jiang Q, Crews LA, Court Recart A, Jamieson CH. Regulation of Self-Renewal through Modulation of Let-7 Stem Cell Regulatory Family of microRNAs in Chronic Myeloid Leukemia Stem Cells Blood. 124: 4527-4527. DOI: 10.1182/Blood.V124.21.4527.4527  0.31
2014 Lazzari E, Crews LA, Zipeto MA, Ali S, Jamieson CH. Tracking Human Myeloma Cell Therapeutic Resistance Using a Novel Diagnostic Assay for Detection of RNA Editing Biomarkers of Cancer Stem Cell Generation Blood. 124: 3406-3406. DOI: 10.1182/Blood.V124.21.3406.3406  0.301
2014 Jiang Q, Zipeto M, Cournt A, Leu H, Crews L, Morris S, Jamieson C. Abstract 5103: RNA editing enzyme induces accelerated cell cycle in normal hematopoiesis Cancer Research. 74: 5103-5103. DOI: 10.1158/1538-7445.Am2014-5103  0.323
2013 Jiang Q, Crews LA, Barrett CL, Chun HJ, Court AC, Isquith JM, Zipeto MA, Goff DJ, Minden M, Sadarangani A, Rusert JM, Dao KH, Morris SR, Goldstein LS, Marra MA, et al. ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia. Proceedings of the National Academy of Sciences of the United States of America. 110: 1041-6. PMID 23275297 DOI: 10.1073/Pnas.1213021110  0.304
2013 Crews LA, Jamieson CH. Selective elimination of leukemia stem cells: hitting a moving target. Cancer Letters. 338: 15-22. PMID 22906415 DOI: 10.1016/J.Canlet.2012.08.006  0.311
2012 Desplats P, Spencer B, Crews L, Pathel P, Morvinski-Friedmann D, Kosberg K, Roberts S, Patrick C, Winner B, Winkler J, Masliah E. α-Synuclein induces alterations in adult neurogenesis in Parkinson disease models via p53-mediated repression of Notch1. The Journal of Biological Chemistry. 287: 31691-702. PMID 22833673 DOI: 10.1074/Jbc.M112.354522  0.486
2012 Tsigelny IF, Sharikov Y, Wrasidlo W, Gonzalez T, Desplats PA, Crews L, Spencer B, Masliah E. Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation. The Febs Journal. 279: 1000-13. PMID 22251432 DOI: 10.1111/J.1742-4658.2012.08489.X  0.433
2012 Jiang Q, Leu H, Shih A, Goff D, Court-Recart A, Ma W, Smith K, Sadarangani A, Geron I, Barrett C, Frazer KA, Crews LA, Jamieson CHm. Abstract 5217: RNA editing enzyme ADAR1 drives leukemia stem cell differentiation and self-renewal in chronic myeloid leukemia Cancer Research. 72: 5217-5217. DOI: 10.1158/1538-7445.Am2012-5217  0.332
2012 Ubhi K, Crews L, Masliah E. Alpha-Synuclein and Neurodegeneration Primer On the Autonomic Nervous System. 303-305. DOI: 10.1016/B978-0-12-386525-0.00063-9  0.386
2011 Crews L, Ruf R, Patrick C, Dumaop W, Trejo-Morales M, Achim CL, Rockenstein E, Masliah E. Phosphorylation of collapsin response mediator protein-2 disrupts neuronal maturation in a model of adult neurogenesis: Implications for neurodegenerative disorders. Molecular Neurodegeneration. 6: 67. PMID 21943307 DOI: 10.1186/1750-1326-6-67  0.5
2011 Rockenstein E, Ubhi K, Doppler E, Novak P, Moessler H, Li B, Blanchard J, Grundke-Iqbal I, Iqbal K, Mante M, Adame A, Crews L, Masliah E. Regional comparison of the neurogenic effects of CNTF-derived peptides and cerebrolysin in AβPP transgenic mice. Journal of Alzheimer's Disease : Jad. 27: 743-52. PMID 21860085 DOI: 10.3233/Jad-2011-110914  0.465
2011 Paulino AD, Ubhi K, Rockenstein E, Adame A, Crews L, Letendre S, Ellis R, Everall IP, Grant I, Masliah E. Neurotoxic effects of the HCV core protein are mediated by sustained activation of ERK via TLR2 signaling. Journal of Neurovirology. 17: 327-40. PMID 21660601 DOI: 10.1007/S13365-011-0039-0  0.419
2011 Masliah E, Rockenstein E, Mante M, Crews L, Spencer B, Adame A, Patrick C, Trejo M, Ubhi K, Rohn TT, Mueller-Steiner S, Seubert P, Barbour R, McConlogue L, Buttini M, et al. Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease. Plos One. 6: e19338. PMID 21559417 DOI: 10.1371/Journal.Pone.0019338  0.492
2011 Patrick C, Crews L, Desplats P, Dumaop W, Rockenstein E, Achim CL, Everall IP, Masliah E. Increased CDK5 expression in HIV encephalitis contributes to neurodegeneration via tau phosphorylation and is reversed with Roscovitine. The American Journal of Pathology. 178: 1646-61. PMID 21435449 DOI: 10.1016/J.Ajpath.2010.12.033  0.495
2011 Crews L, Patrick C, Adame A, Rockenstein E, Masliah E. Modulation of aberrant CDK5 signaling rescues impaired neurogenesis in models of Alzheimer's disease. Cell Death & Disease. 2: e120. PMID 21368891 DOI: 10.1038/Cddis.2011.2  0.555
2010 Crews L, Adame A, Patrick C, Delaney A, Pham E, Rockenstein E, Hansen L, Masliah E. Increased BMP6 levels in the brains of Alzheimer's disease patients and APP transgenic mice are accompanied by impaired neurogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 12252-62. PMID 20844121 DOI: 10.1523/Jneurosci.1305-10.2010  0.539
2010 Pham E, Crews L, Ubhi K, Hansen L, Adame A, Cartier A, Salmon D, Galasko D, Michael S, Savas JN, Yates JR, Glabe C, Masliah E. Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins. The Febs Journal. 277: 3051-67. PMID 20573181 DOI: 10.1111/J.1742-4658.2010.07719.X  0.529
2010 Crews L, Masliah E. Molecular mechanisms of neurodegeneration in Alzheimer's disease. Human Molecular Genetics. 19: R12-20. PMID 20413653 DOI: 10.1093/Hmg/Ddq160  0.549
2010 Crews L, Spencer B, Desplats P, Patrick C, Paulino A, Rockenstein E, Hansen L, Adame A, Galasko D, Masliah E. Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy. Plos One. 5: e9313. PMID 20174468 DOI: 10.1371/Journal.Pone.0009313  0.569
2010 Crews L, Rockenstein E, Masliah E. APP transgenic modeling of Alzheimer's disease: mechanisms of neurodegeneration and aberrant neurogenesis. Brain Structure & Function. 214: 111-26. PMID 20091183 DOI: 10.1007/S00429-009-0232-6  0.536
2009 Desplats P, Lee HJ, Bae EJ, Patrick C, Rockenstein E, Crews L, Spencer B, Masliah E, Lee SJ. Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proceedings of the National Academy of Sciences of the United States of America. 106: 13010-5. PMID 19651612 DOI: 10.1073/Pnas.0903691106  0.537
2009 Crews L, Tsigelny I, Hashimoto M, Masliah E. Role of synucleins in Alzheimer's disease. Neurotoxicity Research. 16: 306-17. PMID 19551456 DOI: 10.1007/S12640-009-9073-6  0.561
2009 Crews L, Patrick C, Achim CL, Everall IP, Masliah E. Molecular pathology of neuro-AIDS (CNS-HIV). International Journal of Molecular Sciences. 10: 1045-63. PMID 19399237 DOI: 10.3390/Ijms10031045  0.464
2009 Ubhi K, Rockenstein E, Doppler E, Mante M, Adame A, Patrick C, Trejo M, Crews L, Paulino A, Moessler H, Masliah E. Neurofibrillary and neurodegenerative pathology in APP-transgenic mice injected with AAV2-mutant TAU: neuroprotective effects of Cerebrolysin. Acta Neuropathologica. 117: 699-712. PMID 19252918 DOI: 10.1007/S00401-009-0505-4  0.53
2009 Rose JB, Crews L, Rockenstein E, Adame A, Mante M, Hersh LB, Gage FH, Spencer B, Potkar R, Marr RA, Masliah E. Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 1115-25. PMID 19176820 DOI: 10.1523/Jneurosci.4220-08.2009  0.529
2009 Marongiu R, Spencer B, Crews L, Adame A, Patrick C, Trejo M, Dallapiccola B, Valente EM, Masliah E. Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson's disease by disturbing calcium flux. Journal of Neurochemistry. 108: 1561-74. PMID 19166511 DOI: 10.1111/J.1471-4159.2009.05932.X  0.735
2009 Crews L, Spencer B, Masliah E. Role of Aβ degrading enzymes in synaptic plasticity and neurogenesis in Alzheimer's disease Current Hypotheses and Research Milestones in Alzheimer's Disease. 3-12. DOI: 10.1007/978-0-387-87995-6_1  0.395
2008 Spencer B, Marr RA, Rockenstein E, Crews L, Adame A, Potkar R, Patrick C, Gage FH, Verma IM, Masliah E. Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice. Bmc Neuroscience. 9: 109. PMID 19014502 DOI: 10.1186/1471-2202-9-109  0.506
2008 Crews L, Lentz MR, Gonzalez RG, Fox HS, Masliah E. Neuronal injury in simian immunodeficiency virus and other animal models of neuroAIDS. Journal of Neurovirology. 14: 327-39. PMID 18780234 DOI: 10.1080/13550280802132840  0.446
2008 Tsigelny IF, Crews L, Desplats P, Shaked GM, Sharikov Y, Mizuno H, Spencer B, Rockenstein E, Trejo M, Platoshyn O, Yuan JX, Masliah E. Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases. Plos One. 3: e3135. PMID 18769546 DOI: 10.1371/Journal.Pone.0003135  0.565
2008 Crews L, Rockenstein E, Masliah E. Biological transgenic mouse models of Alzheimer's disease. Handbook of Clinical Neurology. 89: 291-301. PMID 18631753 DOI: 10.1016/S0072-9752(07)01227-4  0.501
2008 Doppler E, Rockenstein E, Ubhi K, Inglis C, Mante M, Adame A, Crews L, Hitzl M, Moessler H, Masliah E. Neurotrophic effects of Cerebrolysin in the Mecp2(308/Y) transgenic model of Rett syndrome. Acta Neuropathologica. 116: 425-37. PMID 18600331 DOI: 10.1007/S00401-008-0407-X  0.466
2008 Crews L, Mizuno H, Desplats P, Rockenstein E, Adame A, Patrick C, Winner B, Winkler J, Masliah E. Alpha-synuclein alters Notch-1 expression and neurogenesis in mouse embryonic stem cells and in the hippocampus of transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 4250-60. PMID 18417705 DOI: 10.1523/Jneurosci.0066-08.2008  0.543
2008 Bar-On P, Crews L, Koob AO, Mizuno H, Adame A, Spencer B, Masliah E. Statins reduce neuronal alpha-synuclein aggregation in in vitro models of Parkinson's disease. Journal of Neurochemistry. 105: 1656-67. PMID 18248604 DOI: 10.1111/J.1471-4159.2008.05254.X  0.726
2008 Kawahara K, Hashimoto M, Bar-On P, Ho GJ, Crews L, Mizuno H, Rockenstein E, Imam SZ, Masliah E. alpha-Synuclein aggregates interfere with Parkin solubility and distribution: role in the pathogenesis of Parkinson disease. The Journal of Biological Chemistry. 283: 6979-87. PMID 18195004 DOI: 10.1074/Jbc.M710418200  0.545
2008 Doppler EE, Rockenstein E, Moessler H, Mante M, Adame A, Crews L, Masliah E. P2-379: Neuroprotective effects of Cerebrolysin on neurofibrillary pathology in APP-transgenic mice that received neuronal gene transfer with AAV2-Tau Alzheimer's & Dementia. 4: T484-T484. DOI: 10.1016/J.Jalz.2008.05.1457  0.523
2007 Salaria S, Badkoobehi H, Rockenstein E, Crews L, Chana G, Masliah E, Everall IP. Toll-like receptor pathway gene expression is associated with human immunodeficiency virus-associated neurodegeneration. Journal of Neurovirology. 13: 496-503. PMID 18097881 DOI: 10.1080/13550280701558616  0.437
2007 Spencer B, Rockenstein E, Crews L, Marr R, Masliah E. Novel strategies for Alzheimer's disease treatment. Expert Opinion On Biological Therapy. 7: 1853-67. PMID 18034651 DOI: 10.1517/14712598.7.12.1853  0.522
2007 Rockenstein E, Crews L, Masliah E. Transgenic animal models of neurodegenerative diseases and their application to treatment development Advanced Drug Delivery Reviews. 59: 1093-1102. PMID 17869376 DOI: 10.1016/J.Addr.2007.08.013  0.546
2007 Kuczenski R, Everall IP, Crews L, Adame A, Grant I, Masliah E. Escalating dose-multiple binge methamphetamine exposure results in degeneration of the neocortex and limbic system in the rat Experimental Neurology. 207: 42-51. PMID 17603040 DOI: 10.1016/J.Expneurol.2007.05.023  0.434
2007 Letendre S, Paulino AD, Rockenstein E, Adame A, Crews L, Cherner M, Heaton R, Ellis R, Everall IP, Grant I, Masliah E. Pathogenesis of hepatitis C virus coinfection in the brains of patients infected with HIV. The Journal of Infectious Diseases. 196: 361-70. PMID 17597450 DOI: 10.1086/519285  0.406
2007 Tsigelny IF, Bar-On P, Sharikov Y, Crews L, Hashimoto M, Miller MA, Keller SH, Platoshyn O, Yuan JXJ, Masliah E. Dynamics of α-synuclein aggregation and inhibition of pore-like oligomer development by β-synuclein Febs Journal. 274: 1862-1877. PMID 17381514 DOI: 10.1111/J.1742-4658.2007.05733.X  0.505
2007 Rockenstein E, Torrance M, Adame A, Mante M, Bar-on P, Rose JB, Crews L, Masliah E. Neuroprotective effects of regulators of the glycogen synthase kinase-3β signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation Journal of Neuroscience. 27: 1981-1991. PMID 17314294 DOI: 10.1523/Jneurosci.4321-06.2007  0.543
2007 Spencer B, Crews L, Masliah E. Climbing the scaffolds of Parkinson's disease pathogenesis. Neuron. 53: 469-70. PMID 17296545 DOI: 10.1016/J.Neuron.2007.02.002  0.527
2007 Rockenstein E, Mante M, Adame A, Crews L, Moessler H, Masliah E. Effects of Cerebrolysin™ on neurogenesis in an APP transgenic model of Alzheimer's disease Acta Neuropathologica. 113: 265-275. PMID 17131129 DOI: 10.1007/S00401-006-0166-5  0.533
2006 Tesseur I, Zou K, Esposito L, Bard F, Berber E, Can JV, Lin AH, Crews L, Tremblay P, Mathews P, Mucke L, Masliah E, Wyss-Coray T. Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology. The Journal of Clinical Investigation. 116: 3060-9. PMID 17080199 DOI: 10.1172/Jci27341  0.514
2006 Chana G, Everall IP, Crews L, Langford D, Adame A, Grant I, Cherner M, Lazzaretto D, Heaton R, Ellis R, Masliah E. Cognitive deficits and degeneration of interneurons in HIV+ methamphetamine users. Neurology. 67: 1486-9. PMID 17060582 DOI: 10.1212/01.Wnl.0000240066.02404.E6  0.409
2006 Masliah E, Crews L, Hansen L. Synaptic remodeling during aging and in Alzheimer's disease Journal of Alzheimer's Disease. 9: 91-99. PMID 16914848 DOI: 10.3233/Jad-2006-9S311  0.429
2006 Rockenstein E, Torrance M, Mante M, Adame A, Paulino A, Rose JB, Crews L, Moessler H, Masliah E. Cerebrolysin decreases amyloid-β production by regulating amyloid protein precursor maturation in a transgenic model of Alzheimer's disease Journal of Neuroscience Research. 83: 1252-1261. PMID 16511867 DOI: 10.1002/Jnr.20818  0.539
2006 Webster B, Hansen L, Adame A, Crews L, Torrance M, Thal L, Masliah E. Astroglial activation of extracellular-regulated kinase in early stages of Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 65: 142-51. PMID 16462205 DOI: 10.1097/01.Jnen.0000199599.63204.6F  0.504
2006 Rockenstein E, Mante M, Adame A, Crews L, Moessler H, Masliah E. P4-374: Effects of cerebrolysin on neurogenesis in an amyloid precursor protein transgenic animal model of Alzheimer's disease Alzheimer's & Dementia. 2: S628-S628. DOI: 10.1016/J.Jalz.2006.05.2115  0.513
2005 Shults CW, Rockenstein E, Crews L, Adame A, Mante M, Larrea G, Hashimoto M, Song D, Iwatsubo T, Tsuboi K, Masliah E. Neurological and neurodegenerative alterations in a transgenic mouse model expressing human alpha-synuclein under oligodendrocyte promoter: implications for multiple system atrophy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 10689-99. PMID 16291942 DOI: 10.1523/Jneurosci.3527-05.2005  0.512
2005 Singer O, Marr RA, Rockenstein E, Crews L, Coufal NG, Gage FH, Verma IM, Masliah E. Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model. Nature Neuroscience. 8: 1343-9. PMID 16136043 DOI: 10.1038/Nn1531  0.538
2005 Rockenstein E, Mante M, Alford M, Adame A, Crews L, Hashimoto M, Esposito L, Mucke L, Masliah E. High beta-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-beta levels: implications for the treatment of Alzheimer disease. The Journal of Biological Chemistry. 280: 32957-67. PMID 16027115 DOI: 10.1074/Jbc.M507016200  0.524
2005 Masliah E, Rockenstein E, Adame A, Alford M, Crews L, Hashimoto M, Seubert P, Lee M, Goldstein J, Chilcote T, Games D, Schenk D. Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease. Neuron. 46: 857-68. PMID 15953415 DOI: 10.1016/J.Neuron.2005.05.010  0.544
2005 Rockenstein E, Schwach G, Ingolic E, Adame A, Crews L, Mante M, Pfragner R, Schreiner E, Windisch M, Masliah E. Lysosomal pathology associated with α-synuclein accumulation in transgenic models using an eGFP fusion protein Journal of Neuroscience Research. 80: 247-259. PMID 15765523 DOI: 10.1002/Jnr.20446  0.556
2005 Rockenstein E, Adame A, Mante M, Larrea G, Crews L, Windisch M, Moessler H, Masliah E. Amelioration of the cerebrovascular amyloidosis in a transgenic model of Alzheimer's disease with the neurotrophic compound Cerebrolysin™ Journal of Neural Transmission. 112: 269-282. PMID 15657642 DOI: 10.1007/S00702-004-0181-4  0.545
2005 Masliah E, Hansen L, Adame A, Crews L, Bard F, Lee C, Seubert P, Games D, Kirby L, Schenk D. Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease. Neurology. 64: 129-31. PMID 15642916 DOI: 10.1212/01.Wnl.0000148590.39911.Df  0.489
2005 Singer O, Marr RA, Rockenstein E, Crews L, Gage FH, Verma IM, Masliah E. 56. Amelioration of Neurodegenerative and Neuropathological Alterations in a Transgenic Model of Alzheimer's Disease: Targeting BACE1 with Small Interfering RNAs Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.084  0.544
2005 Masliah E, Roberts E, Langford D, Everall I, Crews L, Adame A, Rockenstein E, Fox H. Corrigendum to “Patterns of gene dysregulation in the frontal cortex of patients with HIV encephalitis” Journal of Neuroimmunology. 162: 197. DOI: 10.1016/J.Jneuroim.2005.01.013  0.39
2004 Langford D, Grigorian A, Hurford R, Adame A, Crews L, Masliah E. The role of mitochondrial alterations in the combined toxic effects of human immunodeficiency virus Tat protein and methamphetamine on calbindin positive-neurons Journal of Neurovirology. 10: 327-337. PMID 15765804 DOI: 10.1080/13550280490520961  0.471
2004 Hashimoto M, Kawahara K, Bar-On P, Rockenstein E, Crews L, Masliah E. The role of α-synuclein assembly and metabolism in the pathogenesis of Lewy body disease Journal of Molecular Neuroscience. 24: 343-352. PMID 15655259 DOI: 10.1385/Jmn:24:3:343  0.514
2004 Masliah E, Roberts ES, Langford D, Everall I, Crews L, Adame A, Rockenstein E, Fox HS. Patterns of gene dysregulation in the frontal cortex of patients with HIV encephalitis Journal of Neuroimmunology. 157: 163-175. PMID 15579294 DOI: 10.1016/J.Jneuroim.2004.08.026  0.477
2004 Hashimoto M, Rockenstein E, Mante M, Crews L, Bar-On P, Gage FH, Marr R, Masliah E. An antiaggregation gene therapy strategy for Lewy body disease utilizing beta-synuclein lentivirus in a transgenic model. Gene Therapy. 11: 1713-23. PMID 15483670 DOI: 10.1038/Sj.Gt.3302349  0.526
2004 Crews L, Wyss-Coray T, Masliah E. Insights into the pathogenesis of hydrocephalus from transgenic and experimental animal models. Brain Pathology (Zurich, Switzerland). 14: 312-6. PMID 15446587 DOI: 10.1111/J.1750-3639.2004.Tb00070.X  0.473
2004 Hashimoto M, Bar-On P, Ho G, Takenouchi T, Rockenstein E, Crews L, Masliah E. β-synuclein regulates Akt activity in neuronal cells: A possible mechanism for neuroprotection in Parkinson's disease Journal of Biological Chemistry. 279: 23622-23629. PMID 15026413 DOI: 10.1074/Jbc.M313784200  0.535
2004 Rockenstein E, Mante M, Adame A, Crews L, Laurrea G, Masliah E. P1-296 Neuroprotective effects of compounds regulating the GSK3β pathway in a THY1-amyloid precursor protein transgenic animal model of Alzheimer's disease Neurobiology of Aging. 25: S180. DOI: 10.1016/S0197-4580(04)80609-2  0.513
2003 Hashimoto M, Rockenstein E, Crews L, Masliah E. Role of Protein Aggregation in Mitochondrial Dysfunction and Neurodegeneration in Alzheimer's and Parkinson's Diseases Neuromolecular Medicine. 4: 21-35. PMID 14528050 DOI: 10.1385/Nmm:4:1-2:21  0.564
Low-probability matches (unlikely to be authored by this person)
2013 Balaian L, Crews LA, Zipeto M, Anna K, Ball ED, Burkart MD, Jamieson CH. A Highly Selective SF3B1-Targeted Splicing Inhibitor Reduces Human CD34+ Cell Survival and Self-Renewal In Acute Myeloid Leukemia Blood. 122: 1653-1653. DOI: 10.1182/Blood.V122.21.1653.1653  0.3
2020 Jiang Q, Holm F, Isquith J, Mark A, Mason C, Reynoso E, Morris I, Ma W, Diep R, Pham J, Nasamran C, Xu G, Sasik R, Rosenthal SB, Birmingham A, ... Crews L, et al. Abstract 5726: A-to-I RNA deaminase deregulation in pre-leukemia stem cell evolution Cancer Research. 80: 5726-5726. DOI: 10.1158/1538-7445.Am2020-5726  0.299
2013 Jiang Q, Crews LA, Barrett CL, Court-Recart A, Goff D, Sadarangani A, Rusert J, Morris S, Goldstein L, Chun H, Marra M, Fraser K, Dao K, Minden M, Jamieson C. Abstract 247: ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia. Cancer Research. 73: 247-247. DOI: 10.1158/1538-7445.Am2013-247  0.296
2016 Crews LA, Balaian L, Delos Santos NP, Leu HS, Court AC, Lazzari E, Sadarangani A, Zipeto MA, La Clair JJ, Villa R, Kulidjian A, Storb R, Morris SR, Ball ED, Burkart MD, et al. RNA Splicing Modulation Selectively Impairs Leukemia Stem Cell Maintenance in Secondary Human AML. Cell Stem Cell. PMID 27570067 DOI: 10.1016/J.Stem.2016.08.003  0.294
2012 Crews LA, Jamieson CH. Chronic myeloid leukemia stem cell biology. Current Hematologic Malignancy Reports. 7: 125-32. PMID 22467334 DOI: 10.1007/S11899-012-0121-6  0.29
2017 Garavelli S, Lazzari E, Colombo M, Platonova N, Palano MT, Baccianti F, Galletti S, Neri A, Crews L, Jamieson C, Chiaramonte R. Abstract LB-025: The role of NOTCH pathway in multiple myeloma associated drug resistance Cancer Research. 77. DOI: 10.1158/1538-7445.Am2017-Lb-025  0.287
2017 Lazzari E, Mondala PK, Santos ND, Miller AC, Pineda G, Jiang Q, Leu H, Ali SA, Ganesan AP, Wu CN, Costello C, Minden M, Chiaramonte R, Stewart AK, Crews LA, et al. Alu-dependent RNA editing of GLI1 promotes malignant regeneration in multiple myeloma. Nature Communications. 8: 1922. PMID 29203771 DOI: 10.1038/S41467-017-01890-W  0.28
2016 Colombo M, Galletti S, Bulfamante G, Falleni M, Tosi D, Todoerti K, Lazzari E, Crews LA, Jamieson CH, Ravaioli S, Baccianti F, Garavelli S, Platonova N, Neri A, Chiaramonte R. Multiple myeloma-derived Jagged ligands increases autocrine and paracrine interleukin-6 expression in bone marrow niche. Oncotarget. PMID 27463014 DOI: 10.18632/Oncotarget.10820  0.279
2014 Balaian L, Crews L, Kulidjian A, Ball E, Jamieson C. Abstract 4865: Differential survival and self-renewal of LSC and HSC in aged and leukemic niches Cancer Research. 74: 4865-4865. DOI: 10.1158/1538-7445.Am2014-4865  0.279
2017 Jiang Q, Crews LA, Holm F, Jamieson CHM. RNA editing-dependent epitranscriptome diversity in cancer stem cells. Nature Reviews. Cancer. PMID 28416802 DOI: 10.1038/Nrc.2017.23  0.278
2016 Crews LA, Jiang Q, Balaian L, Leu H, Delos Santos N, Court AC, Sadarangani A, Morris S, Storb RF, Kulidjian A, Ball ED, Jamieson C. Decoding the RNA Editome of Normal Versus Malignant Progenitor Cell Aging Short Title: RNA Editing in Normal Aging and MDS/AML Stem Cells Blood. 128: 1519-1519. DOI: 10.1182/Blood.V128.22.1519.1519  0.277
2014 Crews LA, Jiang Q, Zipeto MA, Court AC, Barrett CL, Marra MA, Frazer KA, Jamieson CHM. Abstract 375: A novel diagnostic assay for detection of primate-specific RNA editing events in leukemia stem cells Cancer Research. 74: 375-375. DOI: 10.1158/1538-7445.Am2014-375  0.27
2012 Ma W, Gutierrez A, Goff DJ, Geron I, Sadarangani A, Jamieson CA, Court AC, Shih AY, Jiang Q, Wu CC, Li K, Smith KM, Crews LA, Gibson NW, Deichaite I, et al. NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches. Plos One. 7: e39725. PMID 22768113 DOI: 10.1371/Journal.Pone.0039725  0.267
2015 Crews LA, Jiang Q, Zipeto MA, Lazzari E, Court AC, Ali S, Barrett CL, Frazer KA, Jamieson CH. An RNA editing fingerprint of cancer stem cell reprogramming. Journal of Translational Medicine. 13: 52. PMID 25889244 DOI: 10.1186/S12967-014-0370-3  0.261
2016 Crews LA, Balaian L, Leu HS, Santos NPD, Court AC, Sadarangani A, Zipeto MA, Clair JJL, Villa R, Morris SR, Storb R, Kulidjian A, Ball ED, Burkart MD, Jamieson CHM. Abstract 915: RNA processing signatures of normal versus malignant progenitor cell aging predict leukemia stem cell sensitivity to RNA splicing modulation Cancer Research. 76: 915-915. DOI: 10.1158/1538-7445.Am2016-915  0.255
2012 Sullivan BD, Crews LA, Sönmez B, de la Paz MF, Comert E, Charoenrook V, de Araujo AL, Pepose JS, Berg MS, Kosheleff VP, Lemp MA. Clinical utility of objective tests for dry eye disease: variability over time and implications for clinical trials and disease management. Cornea. 31: 1000-8. PMID 22475641 DOI: 10.1097/Ico.0B013E318242Fd60  0.244
2012 Lemp MA, Sullivan BD, Crews LA. Biomarkers In Dry Eye Disease European Ophthalmic Review. 6: 157. DOI: 10.17925/Eor.2012.06.03.157  0.233
2018 Crews LA, Mondala P, Lazzari E, Pineda G, Wu C, Costello CL, Jamieson C. Genetic Modulation of Adenosine-to-Inosine RNA Editing Selectively Disrupts Inflammasome and Extracellular Matrix Genes in Multiple Myeloma Blood. 132: 1324-1324. DOI: 10.1182/Blood-2018-99-120326  0.231
2012 Ma W, Gutierrez A, Wei P, Sadarangani A, Goff DJ, Shih AY, Court AC, Jiang Q, Leu H, Wall RH, Crews LA, Look AT, Jamieson CHM. Abstract 1011: NOTCH1 signaling is essential for leukemia initiating cell self-renewal in T-ALL Cancer Research. 72: 1011-1011. DOI: 10.1158/1538-7445.Am2012-1011  0.23
2012 Lemp MA, Crews LA, Bron AJ, Foulks GN, Sullivan BD. Distribution of aqueous-deficient and evaporative dry eye in a clinic-based patient cohort: a retrospective study. Cornea. 31: 472-8. PMID 22378109 DOI: 10.1097/Ico.0B013E318225415A  0.223
2014 Sullivan BD, Crews LA, Messmer EM, Foulks GN, Nichols KK, Baenninger P, Geerling G, Figueiredo F, Lemp MA. Correlations between commonly used objective signs and symptoms for the diagnosis of dry eye disease: clinical implications. Acta Ophthalmologica. 92: 161-6. PMID 23279964 DOI: 10.1111/Aos.12012  0.223
2018 Balaian L, Crews LA, Mayson C, Holm F, Diep RH, Leu H, Kulidjian A, Ball ED, Jamieson C. Comparative Inflammasome Analysis of Bone Marrow Stroma in Aging and Myelofibrosis Blood. 132: 4331-4331. DOI: 10.1182/Blood-2018-99-118993  0.196
2021 Mondala PK, Vora AA, Zhou T, Lazzari E, Ladel L, Luo X, Kim Y, Costello C, MacLeod AR, Jamieson CHM, Crews LA. Selective antisense oligonucleotide inhibition of human IRF4 prevents malignant myeloma regeneration via cell cycle disruption. Cell Stem Cell. PMID 33476575 DOI: 10.1016/j.stem.2020.12.017  0.189
2021 Jiang Q, Isquith J, Ladel L, Mark A, Holm F, Mason C, He Y, Mondala P, Oliver I, Pham J, Ma W, Reynoso E, Ali S, Morris IJ, Diep R, ... ... Crews L, et al. Inflammation-driven deaminase deregulation fuels human pre-leukemia stem cell evolution. Cell Reports. 34: 108670. PMID 33503434 DOI: 10.1016/j.celrep.2020.108670  0.174
2023 Crews LA, Ma W, Ladel L, Pham J, Balaian L, Steel SK, Mondala PK, Diep RH, Wu CN, Mason CN, van der Werf I, Oliver I, Reynoso E, Pineda G, Whisenant TC, et al. Reversal of malignant ADAR1 splice isoform switching with Rebecsinib. Cell Stem Cell. PMID 36803553 DOI: 10.1016/j.stem.2023.01.008  0.174
2023 Platonova N, Lazzari E, Colombo M, Falleni M, Tosi D, Giannandrea D, Citro V, Casati L, Ronchetti D, Bolli N, Neri A, Torricelli F, Crews LA, Jamieson CHM, Chiaramonte R. The Potential of JAG Ligands as Therapeutic Targets and Predictive Biomarkers in Multiple Myeloma. International Journal of Molecular Sciences. 24. PMID 37834003 DOI: 10.3390/ijms241914558  0.151
2023 van der Werf I, Mondala PK, Steel SK, Balaian L, Ladel L, Mason CN, Diep RH, Pham J, Cloos J, Kaspers GJL, Chan WC, Mark A, La Clair JJ, Wentworth P, Fisch KM, ... Crews LA, et al. Detection and targeting of splicing deregulation in pediatric acute myeloid leukemia stem cells. Cell Reports. Medicine. 100962. PMID 36889320 DOI: 10.1016/j.xcrm.2023.100962  0.148
2021 Vora AA, Mondala PK, Costello C, MacLeod AR, Crews LA. Sensitive intranuclear flow cytometric quantification of IRF4 protein in multiple myeloma and normal human hematopoietic cells. Star Protocols. 2: 100565. PMID 34136833 DOI: 10.1016/j.xpro.2021.100565  0.146
2021 Vora AA, Mondala PK, Costello C, MacLeod AR, Crews LA. Sensitive intranuclear flow cytometric quantification of IRF4 protein in multiple myeloma and normal human hematopoietic cells. Star Protocols. 2: 100565. PMID 34136833 DOI: 10.1016/j.xpro.2021.100565  0.146
2022 Holstein SA, Asimakopoulos F, Azab AK, Bianchi G, Bhutani M, Crews LA, Cupedo T, Giles H, Gooding S, Hillengass J, John L, Kaiser S, Lee L, Maclachlan K, Pasquini MC, et al. Proceedings from the BMT CTN Myeloma Intergroup Workshop on Immune and Cellular Therapy in Multiple Myeloma. Transplantation and Cellular Therapy. PMID 35605882 DOI: 10.1016/j.jtct.2022.05.019  0.106
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