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Izumi Maezawa, Ph.D. - Publications

Affiliations: 
University of Washington, Seattle, Seattle, WA 
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49 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Jin LW, Lucente JD, Nguyen HM, Singh V, Singh L, Chavez M, Bushong T, Wulff H, Maezawa I. Repurposing the KCa3.1 inhibitor senicapoc for Alzheimer's disease. Annals of Clinical and Translational Neurology. 6: 723-738. PMID 31019997 DOI: 10.1002/acn3.754  0.36
2019 Zhang L, Zhang S, Maezawa I, Trushin S, Minhas P, Pinto M, Jin LW, Prasain K, Nguyen TDT, Yamazaki Y, Kanekiyo T, Bu G, Gateno B, Chang KO, Nath KA, et al. Corrigendum to "Modulation of mitochondrial complex I activity averts cognitive decline in multiple animal models of familial Alzheimer's disease" [EBioMedicine 2 (2015) 294-305]. Ebiomedicine. PMID 30956174 DOI: 10.1016/j.ebiom.2019.03.062  0.36
2018 Hilt S, Altman R, Kálai T, Maezawa I, Gong Q, Wachsmann-Hogiu S, Jin LW, Voss JC. A Bifunctional Anti-Amyloid Blocks Oxidative Stress and the Accumulation of Intraneuronal Amyloid-Beta. Molecules (Basel, Switzerland). 23. PMID 30103547 DOI: 10.3390/molecules23082010  0.36
2018 Di Lucente J, Nguyen HM, Wulff H, Jin LW, Maezawa I. The voltage-gated potassium channel Kv1.3 is required for microglial pro-inflammatory activation in vivo. Glia. PMID 30043400 DOI: 10.1002/glia.23457  0.36
2018 Chen YJ, Nguyen HM, Maezawa I, Jin LW, Wulff H. Inhibition of the potassium channel Kv1.3 reduces infarction and inflammation in ischemic stroke. Annals of Clinical and Translational Neurology. 5: 147-161. PMID 29468176 DOI: 10.1002/acn3.513  0.36
2018 Jena PK, Sheng L, Di Lucente J, Jin LW, Maezawa I, Wan YY. Dysregulated bile acid synthesis and dysbiosis are implicated in Western diet-induced systemic inflammation, microglial activation, and reduced neuroplasticity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201700984RR. PMID 29401580 DOI: 10.1096/fj.201700984RR  0.36
2017 Maezawa I, Nguyen HM, Di Lucente J, Jenkins DP, Singh V, Hilt S, Kim K, Rangaraju S, Levey AI, Wulff H, Jin LW. Kv1.3 inhibition as a potential microglia-targeted therapy for Alzheimer's disease: preclinical proof of concept. Brain : a Journal of Neurology. PMID 29272333 DOI: 10.1093/brain/awx346  0.36
2017 Chen CY, Di Lucente J, Lin YC, Lien CC, Rogawski MA, Maezawa I, Jin LW. Defective GABAergic neurotransmission in the nucleus tractus solitarius in Mecp2-null mice, a model of Rett syndrome. Neurobiology of Disease. PMID 28927958 DOI: 10.1016/j.nbd.2017.09.006  0.36
2017 Maezawa I, Zou B, Di Lucente J, Cao W, Pascual C, Weerasekara S, Zhang M, Xie XS, Hua DH, Jin LW. The Anti-Amyloid-β and Neuroprotective Properties of a Novel Tricyclic Pyrone Molecule. Journal of Alzheimer's Disease : Jad. PMID 28482635 DOI: 10.3233/JAD-161175  0.36
2016 Hilt S, Tang T, Walton JH, Budamagunta M, Maezawa I, Kálai T, Hideg K, Singh V, Wulff H, Gong Q, Jin LW, Louie A, Voss JC. A Metal-Free Method for Producing MRI Contrast at Amyloid-β. Journal of Alzheimer's Disease : Jad. PMID 27911291 DOI: 10.3233/JAD-160279  0.36
2016 Nguyen HM, Grössinger EM, Horiuchi M, Davis KW, Jin LW, Maezawa I, Wulff H. Differential Kv1.3, KCa3.1, and Kir2.1 expression in "classically" and "alternatively" activated microglia. Glia. PMID 27696527 DOI: 10.1002/glia.23078  0.56
2016 Horiuchi M, Smith L, Maezawa I, Jin LW. CX3CR1 ablation ameliorates motor and respiratory dysfunctions and improves survival of a Rett syndrome mouse model. Brain, Behavior, and Immunity. PMID 26883520 DOI: 10.1016/j.bbi.2016.02.014  0.36
2015 Chen YJ, Nguyen HM, Maezawa I, Grössinger EM, Garing AL, Köhler R, Jin LW, Wulff H. The potassium channel KCa3.1 constitutes a pharmacological target for neuroinflammation associated with ischemia/reperfusion stroke. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 26661208 DOI: 10.1177/0271678X15611434  0.36
2015 Hong HS, Maezawa I, Petrlova J, Zhao XY, Voss JC, Jin LW. Tomoregulin (TMEFF2) Binds Alzheimer's Disease Amyloid-β (Aβ) Oligomer and AβPP and Protects Neurons from Aβ-Induced Toxicity. Journal of Alzheimer's Disease : Jad. PMID 26402097 DOI: 10.3233/JAD-150318  0.56
2015 Altman R, Ly S, Hilt S, Petrlova J, Maezawa I, Kálai T, Hideg K, Jin LW, Laurence TA, Voss JC. Protective spin-labeled fluorenes maintain amyloid beta peptide in small oligomers and limit transitions in secondary structure. Biochimica Et Biophysica Acta. 1854: 1860-1870. PMID 26374940 DOI: 10.1016/j.bbapap.2015.09.002  0.56
2015 Zhang L, Zhang S, Maezawa I, Trushin S, Minhas P, Pinto M, Jin LW, Prasain K, Nguyen TD, Yamazaki Y, Kanekiyo T, Bu G, Gateno B, Chang KO, Nath KA, et al. Modulation of mitochondrial complex I activity averts cognitive decline in multiple animal models of familial Alzheimer's Disease. Ebiomedicine. 2: 294-305. PMID 26086035 DOI: 10.1016/j.ebiom.2015.03.009  0.56
2015 Jin LW, Horiuchi M, Wulff H, Liu XB, Cortopassi GA, Erickson JD, Maezawa I. Dysregulation of glutamine transporter SNAT1 in Rett syndrome microglia: a mechanism for mitochondrial dysfunction and neurotoxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 2516-29. PMID 25673846 DOI: 10.1523/JNEUROSCI.2778-14.2015  0.56
2014 Prior AM, Gunaratna MJ, Kikuchi D, Desper J, Kim Y, Chang KO, Maezawa I, Jin LW, Hua DH. Syntheses of 3-[(Alkylamino)methylene]-6-methylpyridine-2,4(1H,3H)-diones, 3-Substituted 7-Methyl-2H-pyrano[3,2-c]pyridine-2,5(6H)-dione Fluorescence Probes, and Tetrahydro-1H,9H-2,10-dioxa-9-azaanthracen-1-ones. Synthesis. 46: 2179-2190. PMID 25177061 DOI: 10.1055/s-0033-1339027  0.56
2014 Lu J, Maezawa I, Weerasekara S, Erenler R, Nguyen TD, Nguyen J, Swisher LZ, Li J, Jin LW, Ranjan A, Srivastava SK, Hua DH. Syntheses, neural protective activities, and inhibition of glycogen synthase kinase-3β of substituted quinolines. Bioorganic & Medicinal Chemistry Letters. 24: 3392-7. PMID 24951331 DOI: 10.1016/j.bmcl.2014.05.085  0.56
2014 Kálai T, Altman R, Maezawa I, Balog M, Morisseau C, Petrlova J, Hammock BD, Jin LW, Trudell JR, Voss JC, Hideg K. Synthesis and functional survey of new Tacrine analogs modified with nitroxides or their precursors. European Journal of Medicinal Chemistry. 77: 343-50. PMID 24657571 DOI: 10.1016/j.ejmech.2014.03.026  0.56
2014 Monji A, Maezawa I, Mizoguchi Y, Kato TA, Jin LW. Neurodevelopmental and neuropsychiatric disorders Microglia in Health and Disease. 345-372. DOI: 10.1007/978-1-4939-1429-6_14  0.56
2013 Yasui DH, Xu H, Dunaway KW, Lasalle JM, Jin LW, Maezawa I. MeCP2 modulates gene expression pathways in astrocytes. Molecular Autism. 4: 3. PMID 23351786 DOI: 10.1186/2040-2392-4-3  0.36
2012 Pokhrel L, Maezawa I, Nguyen TD, Chang KO, Jin LW, Hua DH. Inhibition of Acyl-CoA: cholesterol acyltransferase (ACAT), overexpression of cholesterol transporter gene, and protection of amyloid β (Aβ) oligomers-induced neuronal cell death by tricyclic pyrone molecules. Journal of Medicinal Chemistry. 55: 8969-73. PMID 23025824 DOI: 10.1021/jm3012189  0.56
2012 Maezawa I, Jenkins DP, Jin BE, Wulff H. Microglial KCa3.1 Channels as a Potential Therapeutic Target for Alzheimer's Disease. International Journal of Alzheimer's Disease. 2012: 868972. PMID 22675649 DOI: 10.1155/2012/868972  0.56
2012 Petrlova J, Kálai T, Maezawa I, Altman R, Harishchandra G, Hong HS, Bricarello DA, Parikh AN, Lorigan GA, Jin LW, Hideg K, Voss JC. The influence of spin-labeled fluorene compounds on the assembly and toxicity of the aβ peptide. Plos One. 7: e35443. PMID 22558151 DOI: 10.1371/journal.pone.0035443  0.56
2012 Horiuchi M, Maezawa I, Itoh A, Wakayama K, Jin LW, Itoh T, Decarli C. Amyloid β1-42 oligomer inhibits myelin sheet formation in vitro. Neurobiology of Aging. 33: 499-509. PMID 20594620 DOI: 10.1016/j.neurobiolaging.2010.05.007  0.56
2011 Maezawa I, Calafiore M, Wulff H, Jin LW. Does microglial dysfunction play a role in autism and Rett syndrome? Neuron Glia Biology. 7: 85-97. PMID 22717189 DOI: 10.1017/S1740925X1200004X  0.56
2011 Greco CM, Navarro CS, Hunsaker MR, Maezawa I, Shuler JF, Tassone F, Delany M, Au JW, Berman RF, Jin LW, Schumann C, Hagerman PJ, Hagerman RJ. Neuropathologic features in the hippocampus and cerebellum of three older men with fragile X syndrome. Molecular Autism. 2: 2. PMID 21303513 DOI: 10.1186/2040-2392-2-2  0.56
2011 Maezawa I, Zimin PI, Wulff H, Jin LW. Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity. The Journal of Biological Chemistry. 286: 3693-706. PMID 20971854 DOI: 10.1074/jbc.M110.135244  0.56
2010 Maezawa I, Jin LW. Rett syndrome microglia damage dendrites and synapses by the elevated release of glutamate. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 5346-56. PMID 20392956 DOI: 10.1523/JNEUROSCI.5966-09.2010  0.56
2010 Hong HS, Maezawa I, Budamagunta M, Rana S, Shi A, Vassar R, Liu R, Lam KS, Cheng RH, Hua DH, Voss JC, Jin LW. Candidate anti-A beta fluorene compounds selected from analogs of amyloid imaging agents. Neurobiology of Aging. 31: 1690-9. PMID 19022536 DOI: 10.1016/j.neurobiolaging.2008.09.019  0.56
2009 Maezawa I, Swanberg S, Harvey D, LaSalle JM, Jin LW. Rett syndrome astrocytes are abnormal and spread MeCP2 deficiency through gap junctions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 5051-61. PMID 19386901 DOI: 10.1523/JNEUROSCI.0324-09.2009  0.56
2008 Maezawa I, Hong HS, Liu R, Wu CY, Cheng RH, Kung MP, Kung HF, Lam KS, Oddo S, Laferla FM, Jin LW. Congo red and thioflavin-T analogs detect Abeta oligomers. Journal of Neurochemistry. 104: 457-68. PMID 17953662 DOI: 10.1111/j.1471-4159.2007.04972.x  0.56
2007 Hong HS, Maezawa I, Yao N, Xu B, Diaz-Avalos R, Rana S, Hua DH, Cheng RH, Lam KS, Jin LW. Combining the rapid MTT formazan exocytosis assay and the MC65 protection assay led to the discovery of carbazole analogs as small molecule inhibitors of Aβ oligomer-induced cytotoxicity Brain Research. 1130: 223-234. PMID 17157826 DOI: 10.1016/j.brainres.2006.10.093  0.56
2006 Maezawa I, Zaja-Milatovic S, Milatovic D, Stephen C, Sokal I, Maeda N, Montine TJ, Montine KS. Apolipoprotein E isoform-dependent dendritic recovery of hippocampal neurons following activation of innate immunity. Journal of Neuroinflammation. 3: 21. PMID 16934151 DOI: 10.1186/1742-2094-3-21  0.56
2006 Ramos EM, Lin MT, Larson EB, Maezawa I, Tseng LH, Edwards KL, Schellenberg GD, Hansen JA, Kukull WA, Jin LW. Tumor necrosis factor alpha and interleukin 10 promoter region polymorphisms and risk of late-onset Alzheimer disease. Archives of Neurology. 63: 1165-9. PMID 16908746 DOI: 10.1001/archneur.63.8.1165  0.56
2006 Maezawa I, Hong HS, Wu HC, Battina SK, Rana S, Iwamoto T, Radke GA, Pettersson E, Martin GM, Hua DH, Jin LW. A novel tricyclic pyrone compound ameliorates cell death associated with intracellular amyloid-beta oligomeric complexes. Journal of Neurochemistry. 98: 57-67. PMID 16805796 DOI: 10.1111/j.1471-4159.2006.03862.x  0.56
2006 Maezawa I, Maeda N, Montine TJ, Montine KS. Apolipoprotein E-specific innate immune response in astrocytes from targeted replacement mice. Journal of Neuroinflammation. 3: 10. PMID 16603079 DOI: 10.1186/1742-2094-3-10  0.56
2006 Maezawa I, Nivison M, Montine KS, Maeda N, Montine TJ. Neurotoxicity from innate immune response is greatest with targeted replacement of E4 allele of apolipoprotein E gene and is mediated by microglial p38MAPK. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 797-9. PMID 16481366 DOI: 10.1096/fj.05-5423fje  0.56
2006 Kaminksy W, Jin LW, Powell S, Maezawa I, Claborn K, Branham C, Kahr B. Polarimetric imaging of amyloid. Micron (Oxford, England : 1993). 37: 324-38. PMID 16406217 DOI: 10.1016/j.micron.2005.10.014  0.56
2005 Woltjer RL, Nghiem W, Maezawa I, Milatovic D, Vaisar T, Montine KS, Montine TJ. Role of glutathione in intracellular amyloid-alpha precursor protein/carboxy-terminal fragment aggregation and associated cytotoxicity. Journal of Neurochemistry. 93: 1047-56. PMID 15857408 DOI: 10.1111/j.1471-4159.2005.03109.x  0.56
2004 Maezawa I, Jin LW, Woltjer RL, Maeda N, Martin GM, Montine TJ, Montine KS. Apolipoprotein E isoforms and apolipoprotein AI protect from amyloid precursor protein carboxy terminal fragment-associated cytotoxicity. Journal of Neurochemistry. 91: 1312-21. PMID 15584908 DOI: 10.1111/j.1471-4159.2004.02818.x  0.56
2004 Shie FS, Neely MD, Maezawa I, Wu H, Olson SJ, Jürgens G, Montine KS, Montine TJ. Oxidized low-density lipoprotein is present in astrocytes surrounding cerebral infarcts and stimulates astrocyte interleukin-6 secretion. The American Journal of Pathology. 164: 1173-81. PMID 15039206 DOI: 10.1016/S0002-9440(10)63205-1  0.56
2004 Jin LW, Shie FS, Maezawa I, Vincent I, Bird T. Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities. The American Journal of Pathology. 164: 975-85. PMID 14982851  0.56
2003 Woltjer RL, Maezawa I, Ou JJ, Montine KS, Montine TJ. Advanced glycation endproduct precursor alters intracellular amyloid-beta/A beta PP carboxy-terminal fragment aggregation and cytotoxicity. Journal of Alzheimer's Disease : Jad. 5: 467-76. PMID 14757937  0.56
2003 Jin LW, Claborn KA, Kurimoto M, Geday MA, Maezawa I, Sohraby F, Estrada M, Kaminksy W, Kahr B. Imaging linear birefringence and dichroism in cerebral amyloid pathologies. Proceedings of the National Academy of Sciences of the United States of America. 100: 15294-8. PMID 14668440 DOI: 10.1073/pnas.2534647100  0.56
2002 Maezawa I, Wang B, Hu Q, Martin GM, Jin LW, Oshima J. Alterations of chaperone protein expression in presenilin mutant neurons in response to glutamate excitotoxicity. Pathology International. 52: 551-4. PMID 12406183 DOI: 10.1046/j.1440-1827.2002.01398.x  0.56
2002 Jin LW, Hua DH, Shie FS, Maezawa I, Sopher B, Martin GM. Novel tricyclic pyrone compounds prevent intracellular APP C99-induced cell death. Journal of Molecular Neuroscience : Mn. 19: 57-61. PMID 12212794 DOI: 10.1007/s12031-002-0011-9  0.56
1997 Yamada K, Umegaki H, Maezawa I, Iguchi A, Kameyama T, Nabeshima T. Possible involvement of catalase in the protective effect of interleukin-6 against 6-hydroxydopamine toxicity in PC12 cells. Brain Research Bulletin. 43: 573-7. PMID 9254029 DOI: 10.1016/S0361-9230(96)00336-X  0.56
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