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Anne L. Brunkan, Ph.D. - Publications

Affiliations: 
Washington University, Saint Louis, St. Louis, MO 
Area:
http://www.researchprofiles.collexis.com/jad/expert.asp?u_id=72
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12 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2005 Brunkan AL, Martinez M, Wang J, Walker ES, Beher D, Shearman MS, Goate AM. Two domains within the first putative transmembrane domain of presenilin 1 differentially influence presenilinase and gamma-secretase activity. Journal of Neurochemistry. 94: 1315-28. PMID 16001967 DOI: 10.1111/J.1471-4159.2005.03278.X  0.734
2005 Brunkan AL, Martinez M, Walker ES, Goate AM. Presenilin endoproteolysis is an intramolecular cleavage. Molecular and Cellular Neurosciences. 29: 65-73. PMID 15866047 DOI: 10.1016/J.Mcn.2004.12.012  0.739
2005 Brunkan AL, Goate AM. Presenilin function and gamma-secretase activity. Journal of Neurochemistry. 93: 769-92. PMID 15857382 DOI: 10.1111/J.1471-4159.2005.03099.X  0.633
2005 Brunkan AL, Martinez M, Wang J, Walker ES, Goate AM. A domain at the C-terminus of PS1 is required for presenilinase and gamma-secretase activities. Journal of Neurochemistry. 92: 1158-69. PMID 15715666 DOI: 10.1111/J.1471-4159.2004.02945.X  0.692
2005 Walker ES, Martinez M, Brunkan AL, Goate A. Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios. Journal of Neurochemistry. 92: 294-301. PMID 15663477 DOI: 10.1111/J.1471-4159.2004.02858.X  0.715
2004 Wang J, Brunkan AL, Hecimovic S, Walker E, Goate A. Conserved "PAL" sequence in presenilins is essential for gamma-secretase activity, but not required for formation or stabilization of gamma-secretase complexes. Neurobiology of Disease. 15: 654-66. PMID 15056474 DOI: 10.1016/J.Nbd.2003.12.008  0.73
2004 Walker ES, Martinez M, Brunkan A, Hecimovic S, Wang J, Goate A. P4-309 Presenilin 2 familial Alzheimer's disease mutation decrease Aβ and CTFγ while differentially affecting NICD production Neurobiology of Aging. 25: S563. DOI: 10.1016/S0197-4580(04)81867-0  0.645
2004 Brunkan AL, Martinez M, Goate AM. P4-283 Endoproteolysis of presenilin-1 is an intramolecular autocatalytic event Neurobiology of Aging. 25: S555-S556. DOI: 10.1016/S0197-4580(04)81841-4  0.405
2003 Schroeter EH, Ilagan MX, Brunkan AL, Hecimovic S, Li YM, Xu M, Lewis HD, Saxena MT, De Strooper B, Coonrod A, Tomita T, Iwatsubo T, Moore CL, Goate A, Wolfe MS, et al. A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis. Proceedings of the National Academy of Sciences of the United States of America. 100: 13075-80. PMID 14566063 DOI: 10.1073/Pnas.1735338100  0.636
2002 Zhou Y, Zhang W, Easton R, Ray JW, Lampe P, Jiang Z, Brunkan AL, Goate A, Johnson EM, Wu JY. Presenilin-1 protects against neuronal apoptosis caused by its interacting protein PAG. Neurobiology of Disease. 9: 126-38. PMID 11895366 DOI: 10.1006/Nbdi.2001.0472  0.529
2000 Ray WJ, Brunkan A, Schroeter EH, Kopan R, Goate AM. APP and notch proteolysis by γ-secretase requires that these substrates complex with PS1 Neurobiology of Aging. 21: 184. DOI: 10.1016/S0197-4580(00)82169-7  0.56
2000 Brunkan A, Ray WJ, Goate AM. The stability and endoproteolysis of endogenous presenilin-1 Neurobiology of Aging. 21: 181. DOI: 10.1016/S0197-4580(00)82152-1  0.41
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