Martin J. Lohse - Publications

Affiliations: 
1993- Pharmacology University of Würzburg, Würzburg, Bayern, Germany 
Area:
Pharmacology; Receptors; Cell Signaling
Website:
http://www.pharmakologie.uni-wuerzburg.de/en/startpage/

360 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Fasciani I, Petragnano F, Wang Z, Edwards R, Telugu N, Pietrantoni I, Zabel U, Zauber H, Grieben M, Terzenidou ME, Di Gregorio J, Pellegrini C, Santini S, Taddei AR, Pohl B, ... ... Lohse MJ, et al. The C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria and regulates cell respiration under stress conditions. Plos Biology. 22: e3002582. PMID 38683874 DOI: 10.1371/journal.pbio.3002582  0.322
2024 Aydin A, Klenk C, Nemec K, Işbilir A, Martin LM, Zauber H, Rrustemi T, Toka HR, Schuster H, Gong M, Stricker S, Bock A, Bähring S, Selbach M, Lohse MJ, et al. ADAM19 cleaves the PTH receptor and associates with brachydactyly type E. Life Science Alliance. 7. PMID 38331475 DOI: 10.26508/lsa.202302400  0.624
2023 Lohse MJ, Bock A, Zaccolo M. G Protein-Coupled Receptor Signaling: New Insights Define Cellular Nanodomains. Annual Review of Pharmacology and Toxicology. PMID 37683278 DOI: 10.1146/annurev-pharmtox-040623-115054  0.697
2022 Nemec K, Schihada H, Kleinau G, Zabel U, Grushevskyi EO, Scheerer P, Lohse MJ, Maiellaro I. Functional modulation of PTH1R activation and signaling by RAMP2. Proceedings of the National Academy of Sciences of the United States of America. 119: e2122037119. PMID 35914163 DOI: 10.1073/pnas.2122037119  0.379
2022 Rodríguez-Soacha DA, Steinmüller SAM, Işbilir A, Fender J, Deventer MH, Ramírez YA, Tutov A, Sotriffer C, Stove CP, Lorenz K, Lohse MJ, Hislop JN, Decker M. Development of an Indole-Amide-Based Photoswitchable Cannabinoid Receptor Subtype 1 (CBR) "Cis-On" Agonist. Acs Chemical Neuroscience. 13: 2410-2435. PMID 35881914 DOI: 10.1021/acschemneuro.2c00160  0.68
2022 Anton SE, Kayser C, Maiellaro I, Nemec K, Möller J, Koschinski A, Zaccolo M, Annibale P, Falcke M, Lohse MJ, Bock A. Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling. Cell. 185: 1130-1142.e11. PMID 35294858 DOI: 10.1016/j.cell.2022.02.011  0.83
2022 Kayser C, Lohse MJ, Bock A. Real-Time Measurements of Intracellular cAMP Gradients Using FRET-Based cAMP Nanorulers. Methods in Molecular Biology (Clifton, N.J.). 2483: 1-13. PMID 35286666 DOI: 10.1007/978-1-0716-2245-2_1  0.653
2022 Klenk C, Hommers L, Lohse MJ. Proteolytic Cleavage of the Extracellular Domain Affects Signaling of Parathyroid Hormone 1 Receptor. Frontiers in Endocrinology. 13: 839351. PMID 35273573 DOI: 10.3389/fendo.2022.839351  0.404
2021 Bathe-Peters M, Gmach P, Boltz HH, Einsiedel J, Gotthardt M, Hübner H, Gmeiner P, Lohse MJ, Annibale P. Visualization of β-adrenergic receptor dynamics and differential localization in cardiomyocytes. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34088840 DOI: 10.1073/pnas.2101119118  0.731
2021 Schihada H, Nemec K, Lohse MJ, Maiellaro I. Bioluminescence in G Protein-Coupled Receptors Drug Screening Using Nanoluciferase and Halo-Tag Technology. Methods in Molecular Biology (Clifton, N.J.). 2268: 137-147. PMID 34085266 DOI: 10.1007/978-1-0716-1221-7_9  0.352
2021 Bock A, Annibale P, Konrad C, Hannawacker A, Anton SE, Maiellaro I, Zabel U, Sivaramakrishnan S, Falcke M, Lohse MJ. Optical Mapping of cAMP Signaling at the Nanometer Scale. Cell. 184: 2793. PMID 33989549 DOI: 10.1016/j.cell.2021.04.043  0.745
2021 Thibado JK, Tano JY, Lee J, Salas-Estrada L, Provasi D, Strauss A, Marcelo Lamim Ribeiro J, Xiang G, Broichhagen J, Filizola M, Lohse MJ, Levitz J. Differences in interactions between transmembrane domains tune the activation of metabotropic glutamate receptors. Elife. 10. PMID 33880992 DOI: 10.7554/eLife.67027  0.315
2021 Işbilir A, Serfling R, Möller J, Thomas R, De Faveri C, Zabel U, Scarselli M, Beck-Sickinger AG, Bock A, Coin I, Lohse MJ, Annibale P. Determination of G-protein-coupled receptor oligomerization by molecular brightness analyses in single cells. Nature Protocols. PMID 33514946 DOI: 10.1038/s41596-020-00458-1  0.804
2021 Shahraki A, Işbilir A, Dogan B, Lohse MJ, Durdagi S, Birgul-Iyison N. Structural and Functional Characterization of Allatostatin Receptor Type-C of , a Potential Target for Next-Generation Pest Control Agents. Journal of Chemical Information and Modeling. PMID 33476150 DOI: 10.1021/acs.jcim.0c00985  0.32
2020 Işbilir A, Duan Sahbaz B, Tuncgenc G, Bünemann M, Lohse MJ, Birgül-Iyison N. Pharmacological Characterization of the Stick Insect Allatostatin-C Receptor with Its Endogenous Agonist. Acs Omega. 5: 32183-32194. PMID 33376856 DOI: 10.1021/acsomega.0c03382  0.691
2020 Işbilir A, Möller J, Arimont M, Bobkov V, Perpiñá-Viciano C, Hoffmann C, Inoue A, Heukers R, de Graaf C, Smit MJ, Annibale P, Lohse MJ. Advanced fluorescence microscopy reveals disruption of dynamic CXCR4 dimerization by subpocket-specific inverse agonists. Proceedings of the National Academy of Sciences of the United States of America. PMID 33148803 DOI: 10.1073/pnas.2013319117  0.822
2020 Gruteser N, Kohlhas V, Balfanz S, Franzen A, Günther A, Offenhäusser A, Müller F, Nikolaev V, Lohse MJ, Baumann A. Establishing a sensitive fluorescence-based quantification method for cyclic nucleotides. Bmc Biotechnology. 20: 47. PMID 32854679 DOI: 10.1186/S12896-020-00633-Y  0.681
2020 Bock A, Annibale P, Konrad C, Hannawacker A, Anton SE, Maiellaro I, Zabel U, Sivaramakrishnan S, Falcke M, Lohse MJ. Optical Mapping of cAMP Signaling at the Nanometer Scale. Cell. PMID 32846156 DOI: 10.1016/J.Cell.2020.07.035  0.802
2020 Möller J, Isbilir A, Sungkaworn T, Osberg B, Karathanasis C, Sunkara V, Grushevskyi EO, Bock A, Annibale P, Heilemann M, Schütte C, Lohse MJ. Single-molecule analysis reveals agonist-specific dimer formation of µ-opioid receptors. Nature Chemical Biology. PMID 32541966 DOI: 10.1038/S41589-020-0566-1  0.838
2020 Perpina-Viciano C, Isbilir A, Zarca A, Caspar B, Kilpatrick LE, Hill SJ, Smit MJ, Lohse MJ, Hoffmann C. Kinetic analysis of the early signaling steps of the human chemokine receptor CXCR4. Molecular Pharmacology. PMID 32474443 DOI: 10.1124/Mol.119.118448  0.737
2020 Wölfel A, Sättele M, Zechmeister C, Nikolaev VO, Lohse MJ, Boege F, Jahns R, Boivin-Jahns V. Unmasking features of the auto-epitope essential for β -adrenoceptor activation by autoantibodies in chronic heart failure. Esc Heart Failure. PMID 32436653 DOI: 10.1002/Ehf2.12747  0.593
2020 Schihada H, Ma X, Zabel U, Vischer HF, Schulte G, Leurs R, Pockes S, Lohse MJ. Development of a conformational histamine H receptor biosensor for the synchronous screening of agonists and inverse agonists. Acs Sensors. PMID 32397705 DOI: 10.1021/Acssensors.0C00397  0.442
2020 Paisdzior S, Dimitriou IM, Schöpe PC, Annibale P, Scheerer P, Krude H, Lohse MJ, Biebermann H, Kühnen P. Differential Signaling Profiles of MC4R Mutations with Three Different Ligands. International Journal of Molecular Sciences. 21. PMID 32059383 DOI: 10.3390/Ijms21041224  0.754
2020 Bathe-Peters M, Gmach P, Annibale P, Lohse MJ. Linescan microscopy data to extract diffusion coefficient of a fluorescent species using a commercial confocal microscope. Data in Brief. 29: 105063. PMID 32055652 DOI: 10.1016/J.Dib.2019.105063  0.695
2020 Annibale P, Lohse MJ. Spatial heterogeneity in molecular brightness. Nature Methods. PMID 32042187 DOI: 10.1038/S41592-020-0732-0  0.661
2020 Ramsey S, Provasi D, Moeller J, Lohse M, Filizola M. Efficient Prediction of the Effect of Mutations on the Activation Kinetics of G Protein-Coupled Receptors Using a Maximum Caliber Approach Biophysical Journal. 118: 92a-93a. DOI: 10.1016/J.Bpj.2019.11.670  0.42
2019 Heuninck J, Perpina Viciano C, Işbilir A, Caspar B, Capoferri D, Briddon SJ, Durroux T, Hill SJ, Lohse MJ, Milligan G, Pin JP, Hoffmann C. Context-dependent signalling of CXC chemokine receptor 4 (CXCR4) and atypical chemokine receptor 3 (ACKR3). Molecular Pharmacology. PMID 31092552 DOI: 10.1124/Mol.118.115477  0.778
2019 Serfling R, Seidel L, Bock A, Lohse MJ, Annibale P, Coin I. Quantitative single-residue bioorthogonal labeling of G protein-coupled receptors in live cells. Acs Chemical Biology. PMID 31074969 DOI: 10.1021/Acschembio.8B01115  0.822
2019 Grushevskyi EO, Kukaj T, Schmauder R, Bock A, Zabel U, Schwabe T, Benndorf K, Lohse MJ. Stepwise activation of a class C GPCR begins with millisecond dimer rearrangement. Proceedings of the National Academy of Sciences of the United States of America. PMID 31023886 DOI: 10.1073/Pnas.1900261116  0.686
2019 Boivin V, Zechmeister C, Schuetz C, Jahns R, Lohse MJ, Fassnacht MJ, Hahner S. P3561Detection and functional characterization of angiotensin receptor type 1 autoantibodies: establishment and clinical translation European Heart Journal. 40. DOI: 10.1093/Eurheartj/Ehz745.0424  0.326
2018 Godbole A, Lyga S, Lohse MJ, Calebiro D. Publisher Correction: Internalized TSH receptors en route to the TGN induce local G-protein signaling and gene transcription. Nature Communications. 9: 5459. PMID 30568183 DOI: 10.1038/S41467-018-07821-7  0.647
2018 Picard LP, Schönegge AM, Lohse MJ, Bouvier M. Bioluminescence resonance energy transfer-based biosensors allow monitoring of ligand- and transducer-mediated GPCR conformational changes. Communications Biology. 1: 106. PMID 30271986 DOI: 10.1038/s42003-018-0101-z  0.528
2018 Schihada H, Vandenabeele S, Zabel U, Frank M, Lohse MJ, Maiellaro I. A universal bioluminescence resonance energy transfer sensor design enables high-sensitivity screening of GPCR activation dynamics. Communications Biology. 1: 105. PMID 30271985 DOI: 10.1038/s42003-018-0072-0  0.309
2018 Boivin-Jahns V, Uhland K, Holthoff HP, Beyersdorf N, Kocoski V, Kerkau T, Münch G, Lohse MJ, Ungerer M, Jahns R. Cyclopeptide COR-1 to treat beta1-adrenergic receptor antibody-induced heart failure. Plos One. 13: e0201160. PMID 30125285 DOI: 10.1371/Journal.Pone.0201160  0.38
2018 Meral D, Provasi D, Prada-Gracia D, Möller J, Marino K, Lohse MJ, Filizola M. Molecular details of dimerization kinetics reveal negligible populations of transient µ-opioid receptor homodimers at physiological concentrations. Scientific Reports. 8: 7705. PMID 29769636 DOI: 10.1038/S41598-018-26070-8  0.42
2018 Dolles D, Hoffmann M, Gunesch S, Marinelli O, Möller J, Santoni G, Chatonnet A, Lohse MJ, Wittmann HJ, Strasser A, Nabissi M, Maurice T, Decker M. Structure-Activity Relationships and Computational Investigations into the Development of Potent and Balanced Dual-Acting Butyrylcholinesterase Inhibitors and Human Cannabinoid Receptor 2 Ligands with Pro-Cognitive in Vivo Profiles. Journal of Medicinal Chemistry. PMID 29400965 DOI: 10.1021/Acs.Jmedchem.7B01760  0.389
2017 Schönegge AM, Gallion J, Picard LP, Wilkins AD, Le Gouill C, Audet M, Stallaert W, Lohse MJ, Kimmel M, Lichtarge O, Bouvier M. Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity. Nature Communications. 8: 2169. PMID 29255305 DOI: 10.1038/S41467-017-02257-X  0.574
2017 Andressen KW, Ulsund AH, Krobert KA, Lohse MJ, Bünemann M, Levy FO. Related GPCRs couple differently to Gs: preassociation between G protein and 5-HT7 serotonin receptor reveals movement of Gαs upon receptor activation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 29079700 DOI: 10.1096/Fj.201700486R  0.701
2017 Sungkaworn T, Jobin ML, Burnecki K, Weron A, Lohse MJ, Calebiro D. Single-molecule imaging reveals receptor-G protein interactions at cell surface hot spots. Nature. PMID 29045395 DOI: 10.1038/Nature24264  0.741
2017 Godbole A, Lyga S, Lohse MJ, Calebiro D. Internalized TSH receptors en route to the TGN induce local Gs-protein signaling and gene transcription. Nature Communications. 8: 443. PMID 28874659 DOI: 10.1038/S41467-017-00357-2  0.752
2017 Bermudez M, Bock A, Krebs F, Holzgrabe U, Mohr K, Lohse MJ, Wolber G. Ligand-specific restriction of extracellular conformational dynamics constrains signaling of the M2 muscarinic receptor. Acs Chemical Biology. PMID 28585805 DOI: 10.1021/Acschembio.7B00275  0.724
2017 Lohse C, Bock A, Maiellaro I, Hannawacker A, Schad LR, Lohse MJ, Bauer WR. Experimental and mathematical analysis of cAMP nanodomains. Plos One. 12: e0174856. PMID 28406920 DOI: 10.1371/Journal.Pone.0174856  0.625
2016 Maiellaro I, Lohse MJ, Kittel RJ, Calebiro D. cAMP Signals in Drosophila Motor Neurons Are Confined to Single Synaptic Boutons. Cell Reports. 17: 1238-1246. PMID 27783939 DOI: 10.1016/J.Celrep.2016.09.090  0.641
2016 Bock A, Bermudez M, Krebs F, Matera C, Chirinda B, Sydow D, Dallanoce C, Holzgrabe U, De Amici M, Lohse MJ, Wolber G, Mohr K. Ligand Binding Ensembles Determine Graded Agonist Efficacies at a G Protein-Coupled Receptor. The Journal of Biological Chemistry. PMID 27298318 DOI: 10.1074/Jbc.M116.735431  0.719
2016 Nuber S, Zabel U, Lorenz K, Nuber A, Milligan G, Tobin AB, Lohse MJ, Hoffmann C. β-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycle. Nature. PMID 27007855 DOI: 10.1038/Nature17198  0.8
2016 Schmid E, Neef S, Berlin C, Tomasovic A, Kahlert K, Nordbeck P, Deiss K, Denzinger S, Herrmann S, Wettwer E, Weidendorfer M, Becker D, Schäfer F, Wagner N, Ergün S, ... ... Lohse MJ, et al. Erratum: Cardiac RKIP induces a beneficial β-adrenoceptor-dependent positive inotropy. Nature Medicine. 22: 217. PMID 26845407 DOI: 10.1038/nm0216-217c  0.653
2016 Lyga S, Volpe S, Werthmann RC, Götz K, Sungkaworn T, Lohse MJ, Calebiro D. Persistent cAMP signaling by internalized LH receptors in ovarian follicles. Endocrinology. en20151945. PMID 26828746 DOI: 10.1210/En.2015-1945  0.731
2016 Wagner J, Friedrich M, Lohse MJ, Heinze KG. Beyond an ‘On-Off’ Activation Model of G-Protein-Coupled Receptors Biophysical Journal. 110: 640a. DOI: 10.1016/J.Bpj.2015.11.3423  0.504
2015 Schmid E, Neef S, Berlin C, Tomasovic A, Kahlert K, Nordbeck P, Deiss K, Denzinger S, Herrmann S, Wettwer E, Weidendorfer M, Becker D, Schäfer F, Wagner N, Ergün S, ... ... Lohse MJ, et al. Cardiac RKIP induces a beneficial β-adrenoceptor-dependent positive inotropy. Nature Medicine. PMID 26479924 DOI: 10.1038/Nm.3972  0.697
2015 Wagner J, Sungkaworn T, Heinze KG, Lohse MJ, Calebiro D. Single-Molecule Fluorescence Microscopy for the Analysis of Fast Receptor Dynamics. Methods in Molecular Biology (Clifton, N.J.). 1335: 53-66. PMID 26260594 DOI: 10.1007/978-1-4939-2914-6_5  0.69
2015 Lohse MJ. The ins and outs of adrenergic signaling. Journal of Molecular Medicine (Berlin, Germany). 93: 955-62. PMID 26199112 DOI: 10.1007/S00109-015-1323-X  0.402
2015 Lohse MJ, Hofmann KP. Spatial and Temporal Aspects of Signaling by G-Protein-Coupled Receptors. Molecular Pharmacology. 88: 572-8. PMID 26184590 DOI: 10.1124/Mol.115.100248  0.51
2015 Bohn LM, Lohse MJ, Nitabach M, Taghert PH, Smit MJ. Exploring the Biology of GPCRs from In Vitro to In Vivo. Molecular Pharmacology. PMID 26162863 DOI: 10.1124/Mol.115.100750  0.391
2015 Boivin V, Beyersdorf N, Palm D, Nikolaev VO, Schlipp A, Müller J, Schmidt D, Kocoski V, Kerkau T, Hünig T, Ertl G, Lohse MJ, Jahns R. Novel receptor-derived cyclopeptides to treat heart failure caused by anti-β1-adrenoceptor antibodies in a human-analogous rat model. Plos One. 10: e0117589. PMID 25700031 DOI: 10.1371/Journal.Pone.0117589  0.53
2015 Wittmann T, Lohse MJ, Schmitt JP. Phospholamban pentamers attenuate PKA-dependent phosphorylation of monomers. Journal of Molecular and Cellular Cardiology. 80: 90-7. PMID 25562800 DOI: 10.1016/J.Yjmcc.2014.12.020  0.338
2015 Holthoff HP, Goebel S, Li Z, Faßbender J, Reimann A, Zeibig S, Lohse MJ, Münch G, Ungerer M. Prolonged TSH receptor A subunit immunization of female mice leads to a long-term model of Graves' disease, tachycardia, and cardiac hypertrophy. Endocrinology. 156: 1577-89. PMID 25562617 DOI: 10.1210/En.2014-1813  0.301
2015 Calebiro D, Godbole A, Lyga S, Lohse MJ. Trafficking and function of GPCRs in the endosomal compartment. Methods in Molecular Biology (Clifton, N.J.). 1234: 197-211. PMID 25304358 DOI: 10.1007/978-1-4939-1755-6_16  0.71
2015 Boivin V, Beyersdorf N, Palm D, Nikolaev VO, Schlipp A, Müller J, Schmidt D, Kocoski V, Kerkau T, Hunig T, Ertl G, Lohse MJ, Jahns R. Morphometric analysis of rat hearts (therapy-study). Plos One. DOI: 10.1371/Journal.Pone.0117589.T003  0.491
2015 Lohse M. In Vivo-Studies of GPCR Conformational Changes using Fluorescence-Based Assays Biophysical Journal. 108: 358a. DOI: 10.1016/J.Bpj.2014.11.1961  0.462
2014 Calebiro D, Hannawacker A, Lyga S, Bathon K, Zabel U, Ronchi C, Beuschlein F, Reincke M, Lorenz K, Allolio B, Kisker C, Fassnacht M, Lohse MJ. PKA catalytic subunit mutations in adrenocortical Cushing's adenoma impair association with the regulatory subunit. Nature Communications. 5: 5680. PMID 25477193 DOI: 10.1038/Ncomms6680  0.749
2014 Bock A, Kostenis E, Tränkle C, Lohse MJ, Mohr K. Pilot the pulse: controlling the multiplicity of receptor dynamics. Trends in Pharmacological Sciences. 35: 630-8. PMID 25455830 DOI: 10.1016/J.Tips.2014.10.002  0.697
2014 Sungkaworn T, Rieken F, Lohse MJ, Calebiro D. High-resolution spatiotemporal analysis of receptor dynamics by single-molecule fluorescence microscopy. Journal of Visualized Experiments : Jove. e51784. PMID 25145374 DOI: 10.3791/51784  0.733
2014 Di Dalmazi G, Kisker C, Calebiro D, Mannelli M, Canu L, Arnaldi G, Quinkler M, Rayes N, Tabarin A, Laure Jullié M, Mantero F, Rubin B, Waldmann J, Bartsch DK, Pasquali R, ... Lohse M, et al. Novel somatic mutations in the catalytic subunit of the protein kinase A as a cause of adrenal Cushing's syndrome: a European multicentric study. The Journal of Clinical Endocrinology and Metabolism. 99: E2093-100. PMID 25057884 DOI: 10.1210/Jc.2014-2152  0.624
2014 Agarwal SR, Yang PC, Rice M, Singer CA, Nikolaev VO, Lohse MJ, Clancy CE, Harvey RD. Role of membrane microdomains in compartmentation of cAMP signaling. Plos One. 9: e95835. PMID 24752595 DOI: 10.1371/Journal.Pone.0095835  0.594
2014 Beuschlein F, Fassnacht M, Assié G, Calebiro D, Stratakis CA, Osswald A, Ronchi CL, Wieland T, Sbiera S, Faucz FR, Schaak K, Schmittfull A, Schwarzmayr T, Barreau O, Vezzosi D, ... ... Lohse MJ, et al. Constitutive activation of PKA catalytic subunit in adrenal cushing's syndrome New England Journal of Medicine. 370: 1019-1028. PMID 24571724 DOI: 10.1056/Nejmoa1310359  0.603
2014 Lohse MJ, Maiellaro I, Calebiro D. Kinetics and mechanism of G protein-coupled receptor activation. Current Opinion in Cell Biology. 27: 87-93. PMID 24530699 DOI: 10.1016/J.Ceb.2013.11.009  0.753
2014 Ferré S, Casadó V, Devi LA, Filizola M, Jockers R, Lohse MJ, Milligan G, Pin JP, Guitart X. G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives. Pharmacological Reviews. 66: 413-34. PMID 24515647 DOI: 10.1124/Pr.113.008052  0.629
2014 Schiwon M, Weisheit C, Franken L, Gutweiler S, Dixit A, Meyer-Schwesinger C, Pohl JM, Maurice NJ, Thiebes S, Lorenz K, Quast T, Fuhrmann M, Baumgarten G, Lohse MJ, Opdenakker G, et al. Crosstalk between sentinel and helper macrophages permits neutrophil migration into infected uroepithelium. Cell. 156: 456-68. PMID 24485454 DOI: 10.1016/J.Cell.2014.01.006  0.582
2014 Lohse MJ, Hoffmann C. Arrestin interactions with G protein-coupled receptors. Handbook of Experimental Pharmacology. 219: 15-56. PMID 24292823 DOI: 10.1007/978-3-642-41199-1_2  0.743
2013 Volff JN, Selz Y, Hoffmann C, Froschauer A, Schultheis C, Schmidt C, Zhou Q, Bernhardt W, Hanel R, Böhne A, Brunet F, Ségurens B, Couloux A, Bernard-Samain S, Barbe V, ... ... Lohse MJ, et al. Gene amplification and functional diversification of melanocortin 4 receptor at an extremely polymorphic locus controlling sexual maturation in the platyfish. Genetics. 195: 1337-52. PMID 24077304 DOI: 10.1534/Genetics.113.155952  0.64
2013 Nakagawa Y, Nagasawa M, Mogami H, Lohse M, Ninomiya Y, Kojima I. Multimodal function of the sweet taste receptor expressed in pancreatic β-cells: Generation of diverse patterns of intracellular signals by sweet agonists Endocrine Journal. 60: 1191-1206. PMID 23933592 DOI: 10.1507/Endocrj.Ej13-0282  0.417
2013 Emami-Nemini A, Roux T, Leblay M, Bourrier E, Lamarque L, Trinquet E, Lohse MJ. Time-resolved fluorescence ligand binding for G protein-coupled receptors. Nature Protocols. 8: 1307-20. PMID 23764938 DOI: 10.1038/Nprot.2013.073  0.454
2013 Ruppert C, Deiss K, Herrmann S, Vidal M, Oezkur M, Gorski A, Weidemann F, Lohse MJ, Lorenz K. Interference with ERK(Thr188) phosphorylation impairs pathological but not physiological cardiac hypertrophy. Proceedings of the National Academy of Sciences of the United States of America. 110: 7440-5. PMID 23589880 DOI: 10.1073/Pnas.1221999110  0.643
2013 Lohse MJ, Calebiro D. Cell biology: Receptor signals come in waves. Nature. 495: 457-8. PMID 23515157 DOI: 10.1038/Nature12086  0.736
2013 Calebiro D, Rieken F, Wagner J, Sungkaworn T, Zabel U, Borzi A, Cocucci E, Zürn A, Lohse MJ. Single-molecule analysis of fluorescently labeled G-protein-coupled receptors reveals complexes with distinct dynamics and organization. Proceedings of the National Academy of Sciences of the United States of America. 110: 743-8. PMID 23267088 DOI: 10.1073/Pnas.1205798110  0.726
2013 Münch G, Boivin-Jahns V, Holthoff H, Adler K, Lappo M, Truöl S, Degen H, Steiger N, Lohse MJ, Jahns R, Ungerer M. Corrigendum to ‘Administration of the cyclic peptide COR-1 in humans (phase I study):ex vivomeasurements of anti-b1-adrenergic receptor antibody neutralization and of immune parameters’ [Eur J Heart Fail 2012;14:1230-1239] European Journal of Heart Failure. 15: 478-478. DOI: 10.1093/Eurjhf/Hft027  0.318
2013 Agarwal SR, Rice M, Singer CA, Nikolaev V, Lohse M, Harvey RD. Regulation of CAMP Compartmentation by Membrane Microdomains Biophysical Journal. 104: 612a. DOI: 10.1016/J.Bpj.2012.11.3390  0.567
2013 Lohse MJ, Hoffmann C, Calebiro D. Central theme G-protein-coupled receptors: GPCRs - Tracking individual receptors | GPCRs - Einzelnen Rezeptoren auf der Spur Biospektrum. 19: 600-604. DOI: 10.1007/S12268-013-0358-1  0.733
2013 Hoffmann C, Lohse M. FRET in living cells. Receptor conformations in a new light: GPCR-based FRET sensors | Rezeptorkonformationen in neuem Licht: GPCR-basierte FRET-Sensoren: FRET in lebenden Zellen Biospektrum. 19: 258-260. DOI: 10.1007/S12268-013-0304-2  0.682
2012 Boivin-Jahns V, Schlipp A, Hartmann S, Panjwani P, Klingel K, Lohse MJ, Ertl G, Jahns R. Antibodies to cardiac receptors. Herz. 37: 843-8. PMID 23183584 DOI: 10.1007/S00059-012-3699-5  0.328
2012 Münch G, Boivin-Jahns V, Holthoff HP, Adler K, Lappo M, Truöl S, Degen H, Steiger N, Lohse MJ, Jahns R, Ungerer M. Administration of the cyclic peptide COR-1 in humans (phase I study): ex vivo measurements of anti-β1-adrenergic receptor antibody neutralization and of immune parameters. European Journal of Heart Failure. 14: 1230-9. PMID 22968742 DOI: 10.1093/Eurjhf/Hfs118  0.306
2012 Hlavackova V, Zabel U, Frankova D, Bätz J, Hoffmann C, Prezeau L, Pin JP, Blahos J, Lohse MJ. Sequential inter- and intrasubunit rearrangements during activation of dimeric metabotropic glutamate receptor 1. Science Signaling. 5: ra59. PMID 22894836 DOI: 10.1126/Scisignal.2002720  0.779
2012 Vidal M, Wieland T, Lohse MJ, Lorenz K. β-Adrenergic receptor stimulation causes cardiac hypertrophy via a Gβγ/Erk-dependent pathway. Cardiovascular Research. 96: 255-64. PMID 22843704 DOI: 10.1093/Cvr/Cvs249  0.714
2012 Holthoff HP, Zeibig S, Jahns-Boivin V, Bauer J, Lohse MJ, Kääb S, Clauss S, Jahns R, Schlipp A, Münch G, Ungerer M. Detection of anti-β1-AR autoantibodies in heart failure by a cell-based competition ELISA. Circulation Research. 111: 675-84. PMID 22811559 DOI: 10.1161/Circresaha.112.272682  0.321
2012 Deiss K, Kisker C, Lohse MJ, Lorenz K. Raf kinase inhibitor protein (RKIP) dimer formation controls its target switch from Raf1 to G protein-coupled receptor kinase (GRK) 2. The Journal of Biological Chemistry. 287: 23407-17. PMID 22610096 DOI: 10.1074/Jbc.M112.363812  0.697
2012 Hoffmann C, Nuber S, Zabel U, Ziegler N, Winkler C, Hein P, Berlot CH, Bünemann M, Lohse MJ. Comparison of the activation kinetics of the M3 acetylcholine receptor and a constitutively active mutant receptor in living cells. Molecular Pharmacology. 82: 236-45. PMID 22564786 DOI: 10.1124/Mol.112.077578  0.784
2012 Emami-Nemini A, Gohla A, Urlaub H, Lohse MJ, Klenk C. The guanine nucleotide exchange factor Vav2 is a negative regulator of parathyroid hormone receptor/Gq signaling. Molecular Pharmacology. 82: 217-25. PMID 22554804 DOI: 10.1124/Mol.112.078824  0.481
2012 Lohse MJ, Nuber S, Hoffmann C. Fluorescence/bioluminescence resonance energy transfer techniques to study G-protein-coupled receptor activation and signaling. Pharmacological Reviews. 64: 299-336. PMID 22407612 DOI: 10.1124/Pr.110.004309  0.728
2012 Ambrosio M, Lohse MJ. Nonequilibrium activation of a G-protein-coupled receptor. Molecular Pharmacology. 81: 770-7. PMID 22379120 DOI: 10.1124/Mol.112.077693  0.478
2012 Werthmann RC, Volpe S, Lohse MJ, Calebiro D. Persistent cAMP signaling by internalized TSH receptors occurs in thyroid but not in HEK293 cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 2043-8. PMID 22291442 DOI: 10.1096/Fj.11-195248  0.721
2011 Alvarez-Curto E, Prihandoko R, Tautermann CS, Zwier JM, Pediani JD, Lohse MJ, Hoffmann C, Tobin AB, Milligan G. Developing chemical genetic approaches to explore G protein-coupled receptor function: validation of the use of a receptor activated solely by synthetic ligand (RASSL). Molecular Pharmacology. 80: 1033-46. PMID 21880827 DOI: 10.1124/Mol.111.074674  0.731
2011 Börner S, Schwede F, Schlipp A, Berisha F, Calebiro D, Lohse MJ, Nikolaev VO. FRET measurements of intracellular cAMP concentrations and cAMP analog permeability in intact cells. Nature Protocols. 6: 427-38. PMID 21412271 DOI: 10.1038/Nprot.2010.198  0.728
2011 Frölich N, Dees C, Paetz C, Ren X, Lohse MJ, Nikolaev VO, Zenk MH. Distinct pharmacological properties of morphine metabolites at G i-protein and β-arrestin signaling pathways activated by the human μ-opioid receptor Biochemical Pharmacology. 81: 1248-1254. PMID 21396918 DOI: 10.1016/J.Bcp.2011.03.001  0.569
2011 Spille JH, Zürn A, Hoffmann C, Lohse MJ, Harms GS. Rotational diffusion of the α(2a) adrenergic receptor revealed by FlAsH labeling in living cells. Biophysical Journal. 100: 1139-48. PMID 21320460 DOI: 10.1016/J.Bpj.2010.08.080  0.666
2011 Werthmann RC, Lohse MJ, Bünemann M. Temporally resolved cAMP monitoring in endothelial cells uncovers a thrombin-induced [cAMP] elevation mediated via the Ca²+-dependent production of prostacyclin. The Journal of Physiology. 589: 181-93. PMID 21059757 DOI: 10.1113/Jphysiol.2010.200121  0.648
2011 Ambrosio M, Zürn A, Lohse MJ. Sensing G protein-coupled receptor activation. Neuropharmacology. 60: 45-51. PMID 20727363 DOI: 10.1016/J.Neuropharm.2010.08.006  0.547
2011 Ziegler N, Bätz J, Zabel U, Lohse MJ, Hoffmann C. FRET-based sensors for the human M1-, M3-, and M5-acetylcholine receptors. Bioorganic & Medicinal Chemistry. 19: 1048-54. PMID 20716489 DOI: 10.1016/J.Bmc.2010.07.060  0.668
2011 Schartl M, Schories S, Schmidt C, Fischer P, Lampert K, Volff J-, Hoffmann C, Lohse M. Regulation of Onset of Sexual Maturation by Melanocortin Receptor 4 Polymorphisms in Xiphophorus Indian Journal of Science and Technology. 4: 49-49. DOI: 10.17485/Ijst/2011/V4Is8/30877  0.635
2011 Krasel C, Lohse MJ. G protein coupled receptor kinases Xpharm: the Comprehensive Pharmacology Reference. 1-19. DOI: 10.1016/B978-008055232-3.63085-5  0.379
2010 Hoffmann C, Gaietta G, Zürn A, Adams SR, Terrillon S, Ellisman MH, Tsien RY, Lohse MJ. Fluorescent labeling of tetracysteine-tagged proteins in intact cells. Nature Protocols. 5: 1666-77. PMID 20885379 DOI: 10.1038/Nprot.2010.129  0.65
2010 Lampert KP, Schmidt C, Fischer P, Volff JN, Hoffmann C, Muck J, Lohse MJ, Ryan MJ, Schartl M. Determination of onset of sexual maturation and mating behavior by melanocortin receptor 4 polymorphisms. Current Biology : Cb. 20: 1729-34. PMID 20869245 DOI: 10.1016/J.Cub.2010.08.029  0.601
2010 Kenakin T, Agnati LF, Caron M, Fredholm B, Guidoli D, Kobilka B, Lefkowitz RW, Lohse M, Woods A, Fuxe K. International Workshop at the Nobel Forum, Karolinska Institutet on G protein-coupled receptors: finding the words to describe monomers, oligomers, and their molecular mechanisms and defining their meaning. Can a consensus be reached? Journal of Receptor and Signal Transduction Research. 30: 284-6. PMID 20858022 DOI: 10.3109/10799893.2010.512438  0.651
2010 Reiner S, Ambrosio M, Hoffmann C, Lohse MJ. Differential signaling of the endogenous agonists at the beta2-adrenergic receptor. The Journal of Biological Chemistry. 285: 36188-98. PMID 20837485 DOI: 10.1074/Jbc.M110.175604  0.679
2010 Klenk C, Vetter T, Zürn A, Vilardaga JP, Friedman PA, Wang B, Lohse MJ. Formation of a ternary complex among NHERF1, beta-arrestin, and parathyroid hormone receptor. The Journal of Biological Chemistry. 285: 30355-62. PMID 20656684 DOI: 10.1074/Jbc.M110.114900  0.751
2010 Ambrosio M, Lohse MJ. Microscopy: GPCR dimers moving closer. Nature Chemical Biology. 6: 570-1. PMID 20644543 DOI: 10.1038/Nchembio.409  0.337
2010 Jacobs S, Calebiro D, Nikolaev VO, Lohse MJ, Schulz S. Real-time monitoring of somatostatin receptor-cAMP signaling in live pituitary. Endocrinology. 151: 4560-5. PMID 20610560 DOI: 10.1210/En.2010-0341  0.816
2010 Khelashvili G, Dorff K, Shan J, Camacho-Artacho M, Skrabanek L, Vroling B, Bouvier M, Devi LA, George SR, Javitch JA, Lohse MJ, Milligan G, Neubig RR, Palczewski K, Parmentier M, et al. GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base. Bioinformatics (Oxford, England). 26: 1804-5. PMID 20501551 DOI: 10.1093/Bioinformatics/Btq264  0.681
2010 Zürn A, Klenk C, Zabel U, Reiner S, Lohse MJ, Hoffmann C. Site-specific, orthogonal labeling of proteins in intact cells with two small biarsenical fluorophores. Bioconjugate Chemistry. 21: 853-9. PMID 20429545 DOI: 10.1021/Bc900394J  0.659
2010 Volpe S, Thelen S, Pertel T, Lohse MJ, Thelen M. Polarization of migrating monocytic cells is independent of PI 3-kinase activity. Plos One. 5: e10159. PMID 20419163 DOI: 10.1371/Journal.Pone.0010159  0.352
2010 Jahns R, Schlipp A, Boivin V, Lohse MJ. Targeting receptor antibodies in immune cardiomyopathy. Seminars in Thrombosis and Hemostasis. 36: 212-8. PMID 20414837 DOI: 10.1055/S-0030-1251506  0.386
2010 Calebiro D, Nikolaev VO, Lohse MJ. Imaging of persistent cAMP signaling by internalized G protein-coupled receptors. Journal of Molecular Endocrinology. 45: 1-8. PMID 20378719 DOI: 10.1677/Jme-10-0014  0.797
2010 Calebiro D, Nikolaev VO, Persani L, Lohse MJ. Signaling by internalized G-protein-coupled receptors. Trends in Pharmacological Sciences. 31: 221-8. PMID 20303186 DOI: 10.1016/J.Tips.2010.02.002  0.796
2010 Nikolaev VO, Moshkov A, Lyon AR, Miragoli M, Novak P, Paur H, Lohse MJ, Korchev YE, Harding SE, Gorelik J. Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation. Science (New York, N.Y.). 327: 1653-7. PMID 20185685 DOI: 10.1126/Science.1185988  0.754
2010 Lompré AM, Hajjar RJ, Harding SE, Kranias EG, Lohse MJ, Marks AR. Ca2+ cycling and new therapeutic approaches for heart failure. Circulation. 121: 822-30. PMID 20124124 DOI: 10.1161/Circulationaha.109.890954  0.42
2010 Maier-Peuschel M, Frölich N, Dees C, Hommers LG, Hoffmann C, Nikolaev VO, Lohse MJ. A fluorescence resonance energy transfer-based M2 muscarinic receptor sensor reveals rapid kinetics of allosteric modulation. The Journal of Biological Chemistry. 285: 8793-800. PMID 20083608 DOI: 10.1074/Jbc.M109.098517  0.786
2010 Klenk C, Schulz S, Calebiro D, Lohse MJ. Agonist-regulated cleavage of the extracellular domain of parathyroid hormone receptor type 1. The Journal of Biological Chemistry. 285: 8665-74. PMID 20080964 DOI: 10.1074/Jbc.M109.058685  0.758
2010 Wachten S, Masada N, Ayling LJ, Ciruela A, Nikolaev VO, Lohse MJ, Cooper DM. Distinct pools of cAMP centre on different isoforms of adenylyl cyclase in pituitary-derived GH3B6 cells. Journal of Cell Science. 123: 95-106. PMID 20016070 DOI: 10.1242/Jcs.058594  0.565
2010 Lohse MJ. Dimerization in GPCR mobility and signaling. Current Opinion in Pharmacology. 10: 53-8. PMID 19910252 DOI: 10.1016/J.Coph.2009.10.007  0.496
2010 von Hayn K, Werthmann RC, Nikolaev VO, Hommers LG, Lohse MJ, Bünemann M. Gq-mediated Ca2+ signals inhibit adenylyl cyclases 5/6 in vascular smooth muscle cells. American Journal of Physiology. Cell Physiology. 298: C324-32. PMID 19889965 DOI: 10.1152/Ajpcell.00197.2009  0.717
2010 Zürn A, Klenk C, Zabel U, Lohse MJ, Hoffmann C. Site-Specific, Orthogonal Two Color Labeling of Different Proteins with Flash and Reash in Living Cells Biophysical Journal. 98: 393a. DOI: 10.1016/J.Bpj.2009.12.2122  0.679
2009 Beetz N, Harrison MD, Brede M, Zong X, Urbanski MJ, Sietmann A, Kaufling J, Lorkowski S, Barrot M, Seeliger MW, Vieira-Coelho MA, Hamet P, Gaudet D, Seda O, Tremblay J, ... ... Lohse MJ, et al. Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice. The Journal of Clinical Investigation. 119: 3597-3612. PMID 19959875 DOI: 10.1172/Jci38433  0.488
2009 Reiner S, Ziegler N, Leon C, Lorenz K, von Hayn K, Gachet C, Lohse MJ, Hoffmann C. beta-Arrestin-2 interaction and internalization of the human P2Y1 receptor are dependent on C-terminal phosphorylation sites. Molecular Pharmacology. 76: 1162-71. PMID 19741005 DOI: 10.1124/Mol.109.060467  0.81
2009 Calebiro D, Nikolaev VO, Gagliani MC, de Filippis T, Dees C, Tacchetti C, Persani L, Lohse MJ. Persistent cAMP-signals triggered by internalized G-protein-coupled receptors. Plos Biology. 7: e1000172. PMID 19688034 DOI: 10.1371/Journal.Pbio.1000172  0.802
2009 Adachi E, Kazoe Y, Sato Y, Suzuki Y, Urano T, Ueyama T, Saito N, Nikolaev VO, Lohse MJ, Tominaga M, Mogami H. A technique for monitoring multiple signals with a combination of prism-based total internal reflection fluorescence microscopy and epifluorescence microscopy. PflüGers Archiv : European Journal of Physiology. 459: 227-34. PMID 19680684 DOI: 10.1007/S00424-009-0705-8  0.629
2009 Lorenz K, Schmitt JP, Vidal M, Lohse MJ. Cardiac hypertrophy: targeting Raf/MEK/ERK1/2-signaling. The International Journal of Biochemistry & Cell Biology. 41: 2351-5. PMID 19666137 DOI: 10.1016/J.Biocel.2009.08.002  0.632
2009 Werthmann RC, von Hayn K, Nikolaev VO, Lohse MJ, Bünemann M. Real-time monitoring of cAMP levels in living endothelial cells: thrombin transiently inhibits adenylyl cyclase 6. The Journal of Physiology. 587: 4091-104. PMID 19546162 DOI: 10.1113/Jphysiol.2009.172957  0.707
2009 Nakagawa Y, Nagasawa M, Yamada S, Hara A, Mogami H, Nikolaev VO, Lohse MJ, Shigemura N, Ninomiya Y, Kojima I. Sweet taste receptor expressed in pancreatic beta-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion. Plos One. 4: e5106. PMID 19352508 DOI: 10.1371/Journal.Pone.0005106  0.623
2009 Mironov SL, Skorova E, Taschenberger G, Hartelt N, Nikolaev VO, Lohse MJ, Kügler S. Imaging cytoplasmic cAMP in mouse brainstem neurons. Bmc Neuroscience. 10: 29. PMID 19327133 DOI: 10.1186/1471-2202-10-29  0.577
2009 Dorsch S, Klotz KN, Engelhardt S, Lohse MJ, Bünemann M. Analysis of receptor oligomerization by FRAP microscopy. Nature Methods. 6: 225-30. PMID 19234451 DOI: 10.1038/Nmeth.1304  0.789
2009 Ferré S, Baler R, Bouvier M, Caron MG, Devi LA, Durroux T, Fuxe K, George SR, Javitch JA, Lohse MJ, Mackie K, Milligan G, Pfleger KD, Pin JP, Volkow ND, et al. Building a new conceptual framework for receptor heteromers. Nature Chemical Biology. 5: 131-4. PMID 19219011 DOI: 10.1038/Nchembio0309-131  0.656
2009 Vilardaga JP, Bünemann M, Feinstein TN, Lambert N, Nikolaev VO, Engelhardt S, Lohse MJ, Hoffmann C. GPCR and G proteins: drug efficacy and activation in live cells. Molecular Endocrinology (Baltimore, Md.). 23: 590-9. PMID 19196832 DOI: 10.1210/Me.2008-0204  0.848
2009 Schmitt JP, Ahmad F, Lorenz K, Hein L, Schulz S, Asahi M, Maclennan DH, Seidman CE, Seidman JG, Lohse MJ. Alterations of phospholamban function can exhibit cardiotoxic effects independent of excessive sarcoplasmic reticulum Ca2+-ATPase inhibition. Circulation. 119: 436-44. PMID 19139388 DOI: 10.1161/Circulationaha.108.783506  0.727
2009 Zürn A, Zabel U, Vilardaga JP, Schindelin H, Lohse MJ, Hoffmann C. Fluorescence resonance energy transfer analysis of alpha 2a-adrenergic receptor activation reveals distinct agonist-specific conformational changes. Molecular Pharmacology. 75: 534-41. PMID 19106230 DOI: 10.1124/Mol.108.052399  0.799
2009 Lewin G, Matus M, Basu A, Frebel K, Rohsbach SP, Safronenko A, Seidl MD, Stümpel F, Buchwalow I, König S, Engelhardt S, Lohse MJ, Schmitz W, Müller FU. Critical role of transcription factor cyclic AMP response element modulator in beta1-adrenoceptor-mediated cardiac dysfunction. Circulation. 119: 79-88. PMID 19103994 DOI: 10.1161/Circulationaha.108.786533  0.583
2009 Nikolaev VO, Lohse MJ. Novel techniques for real-time monitoring of cGMP in living cells. Handbook of Experimental Pharmacology. 229-43. PMID 19089332 DOI: 10.1007/978-3-540-68964-5_11  0.524
2009 Lorenz K, Schmitt JP, Schmitteckert EM, Lohse MJ. A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy. Nature Medicine. 15: 75-83. PMID 19060905 DOI: 10.1038/Nm.1893  0.688
2009 Dorsch S, Klotz KN, Lohse MJ, Bünemann M. FRAP Microscopy As A Tool To Analyze Beta-Adrenergic Receptor Di-/Oligomerization Biophysical Journal. 96: 677a-678a. DOI: 10.1016/J.Bpj.2008.12.3579  0.705
2008 Krasel C, Zabel U, Lorenz K, Reiner S, Al-Sabah S, Lohse MJ. Dual role of the beta2-adrenergic receptor C terminus for the binding of beta-arrestin and receptor internalization. The Journal of Biological Chemistry. 283: 31840-8. PMID 18801735 DOI: 10.1074/Jbc.M806086200  0.726
2008 Lohse MJ, Klenk C. Blocking them all: beta-arrestins inhibit cellular signaling. Molecular Cell. 31: 619-21. PMID 18775321 DOI: 10.1016/J.Molcel.2008.08.015  0.426
2008 Hoffmann C, Ziegler N, Reiner S, Krasel C, Lohse MJ. Agonist-selective, receptor-specific interaction of human P2Y receptors with beta-arrestin-1 and -2. The Journal of Biological Chemistry. 283: 30933-41. PMID 18703513 DOI: 10.1074/Jbc.M801472200  0.714
2008 Iancu RV, Ramamurthy G, Warrier S, Nikolaev VO, Lohse MJ, Jones SW, Harvey RD. Cytoplasmic cAMP concentrations in intact cardiac myocytes. American Journal of Physiology. Cell Physiology. 295: C414-22. PMID 18550706 DOI: 10.1152/Ajpcell.00038.2008  0.685
2008 Herget S, Lohse MJ, Nikolaev VO. Real-time monitoring of phosphodiesterase inhibition in intact cells. Cellular Signalling. 20: 1423-31. PMID 18467075 DOI: 10.1016/J.Cellsig.2008.03.011  0.589
2008 Shafer OT, Kim DJ, Dunbar-Yaffe R, Nikolaev VO, Lohse MJ, Taghert PH. Widespread receptivity to neuropeptide PDF throughout the neuronal circadian clock network of Drosophila revealed by real-time cyclic AMP imaging. Neuron. 58: 223-37. PMID 18439407 DOI: 10.1016/J.Neuron.2008.02.018  0.52
2008 Lohse MJ, Nikolaev VO, Hein P, Hoffmann C, Vilardaga JP, Bünemann M. Optical techniques to analyze real-time activation and signaling of G-protein-coupled receptors. Trends in Pharmacological Sciences. 29: 159-65. PMID 18262662 DOI: 10.1016/J.Tips.2007.12.002  0.845
2008 Mayer G, Wulffen B, Huber C, Brockmann J, Flicke B, Neumann L, Hafenbradl D, Klebl BM, Lohse MJ, Krasel C, Blind M. An RNA molecule that specifically inhibits G-protein-coupled receptor kinase 2 in vitro. Rna (New York, N.Y.). 14: 524-34. PMID 18230760 DOI: 10.1261/Rna.821908  0.461
2008 Lohse MJ, Hein P, Hoffmann C, Nikolaev VO, Vilardaga JP, Bünemann M. Kinetics of G-protein-coupled receptor signals in intact cells. British Journal of Pharmacology. 153: S125-32. PMID 18193071 DOI: 10.1038/sj.bjp.0707656  0.803
2008 Vilardaga JP, Nikolaev VO, Lorenz K, Ferrandon S, Zhuang Z, Lohse MJ. Conformational cross-talk between alpha2A-adrenergic and mu-opioid receptors controls cell signaling. Nature Chemical Biology. 4: 126-31. PMID 18193048 DOI: 10.1038/Nchembio.64  0.851
2008 Hoffmann C, Zürn A, Bünemann M, Lohse MJ. Conformational changes in G-protein-coupled receptors-the quest for functionally selective conformations is open. British Journal of Pharmacology. 153: S358-66. PMID 18059316 DOI: 10.1038/Sj.Bjp.0707615  0.788
2008 BOIVIN V, NIKOLAEV V, SCHWARZBACH V, SCHLIPP A, YE Y, ANGERMANN C, ERTL G, LOHSE M, JAHNS R. Cardioprotective cyclic peptides and beta-blockers in the therapy of beta1-receptor antibody-induced cardiomyopathy: effects on phenotype and cardiac expression of ANP/BNP/Cytokines European Journal of Heart Failure Supplements. 7: 28-29. DOI: 10.1016/S1567-4215(08)60080-6  0.585
2008 SCHWARZBACH V, BOIVIN V, ROEDER T, NIKOLAEV V, KLINGEL K, ERTL G, LOHSE M, JAHNS R. Development of phenotype and expression of contractile proteins & molecular markers of heart failure over time in beta1-receptor antibody-induced immune-cardiomyopathy European Journal of Heart Failure Supplements. 7: 28-28. DOI: 10.1016/S1567-4215(08)60079-X  0.601
2007 Rohrbach S, Engelhardt S, Lohse MJ, Werdan K, Holtz J, Muller-Werdan U. Activation of AP-1 contributes to the beta-adrenoceptor-mediated myocardial induction of interleukin-6. Molecular Medicine (Cambridge, Mass.). 13: 605-14. PMID 17948064 DOI: 10.2119/2007-00071.Rohrbach  0.55
2007 Lohse MJ, Bünemann M, Hoffmann C, Vilardaga JP, Nikolaev VO. Monitoring receptor signaling by intramolecular FRET. Current Opinion in Pharmacology. 7: 547-53. PMID 17919975 DOI: 10.1016/J.Coph.2007.08.007  0.83
2007 Lohse MJ, Hoffmann C, Nikolaev VO, Vilardaga JP, Bünemann M. Kinetic analysis of G protein-coupled receptor signaling using fluorescence resonance energy transfer in living cells. Advances in Protein Chemistry. 74: 167-88. PMID 17854658 DOI: 10.1016/S0065-3233(07)74005-6  0.846
2007 Nikolaev VO, Boivin V, Störk S, Angermann CE, Ertl G, Lohse MJ, Jahns R. A novel fluorescence method for the rapid detection of functional beta1-adrenergic receptor autoantibodies in heart failure. Journal of the American College of Cardiology. 50: 423-31. PMID 17662395 DOI: 10.1016/J.Jacc.2007.03.051  0.593
2007 Nikolaev VO, Boettcher C, Dees C, Bünemann M, Lohse MJ, Zenk MH. Live cell monitoring of μ-opioid receptor-mediated G-protein activation reveals strong biological activity of close morphine biosynthetic precursors Journal of Biological Chemistry. 282: 27126-27132. PMID 17616524 DOI: 10.1074/Jbc.M703272200  0.771
2007 Skrabanek L, Murcia M, Bouvier M, Devi L, George SR, Lohse MJ, Milligan G, Neubig R, Palczewski K, Parmentier M, Pin JP, Vriend G, Javitch JA, Campagne F, Filizola M. Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base. Bmc Bioinformatics. 8: 177. PMID 17537266 DOI: 10.1186/1471-2105-8-177  0.653
2007 Pin JP, Neubig R, Bouvier M, Devi L, Filizola M, Javitch JA, Lohse MJ, Milligan G, Palczewski K, Parmentier M, Spedding M. International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers. Pharmacological Reviews. 59: 5-13. PMID 17329545 DOI: 10.1124/Pr.59.1.5  0.702
2007 Merkle S, Frantz S, Schön MP, Bauersachs J, Buitrago M, Frost RJ, Schmitteckert EM, Lohse MJ, Engelhardt S. A role for caspase-1 in heart failure. Circulation Research. 100: 645-53. PMID 17303764 DOI: 10.1161/01.Res.0000260203.55077.61  0.503
2007 Warrier S, Ramamurthy G, Eckert RL, Nikolaev VO, Lohse MJ, Harvey RD. cAMP microdomains and L-type Ca2+ channel regulation in guinea-pig ventricular myocytes. The Journal of Physiology. 580: 765-76. PMID 17289786 DOI: 10.1113/Jphysiol.2006.124891  0.656
2007 Knaus A, Zong X, Beetz N, Jahns R, Lohse MJ, Biel M, Hein L. Direct inhibition of cardiac hyperpolarization-activated cyclic nucleotide-gated pacemaker channels by clonidine. Circulation. 115: 872-80. PMID 17261653 DOI: 10.1161/Circulationaha.106.667675  0.509
2007 Rochais F, Vilardaga JP, Nikolaev VO, Bünemann M, Lohse MJ, Engelhardt S. Real-time optical recording of beta1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol. The Journal of Clinical Investigation. 117: 229-35. PMID 17200720 DOI: 10.1172/Jci30012  0.817
2007 Seeland U, Selejan S, Engelhardt S, Müller P, Lohse MJ, Böhm M. Interstitial remodeling in beta1-adrenergic receptor transgenic mice. Basic Research in Cardiology. 102: 183-93. PMID 17122889 DOI: 10.1007/S00395-006-0635-Y  0.53
2007 Nikolaev VO, Lohse MJ. Rapid monitoring of intracellular cGMP Bmc Pharmacology. 7. DOI: 10.1186/1471-2210-7-S1-S21  0.567
2007 Nikolaev VO, Herget S, Lohse MJ. FRET-based method for rapid screening of PDE-inhibitors in living cells Bmc Pharmacology. 7. DOI: 10.1186/1471-2210-7-S1-P43  0.536
2007 Hein P, Hoffmann C, Lohse MJ, Bünemann M. Direct Measurement Of Receptor/Gq Interaction The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A429-A  0.802
2007 BOIVIN V, PALM D, FROST R, HEIN L, ANGERMANN C, ERTL G, LOHSE M, JAHNS R. 115 Combination-therapy with neutralizing cyclopeptides and beta-blockers decreases molecular markers of sympathetic activation and reverses cardiomyopathy in beta1-receptor antibody-induced heart failure European Journal of Heart Failure Supplements. 6: 28-28. DOI: 10.1016/S1567-4215(07)60075-7  0.509
2007 Leroy J, Abi-Gerges A, Richter W, Nikolaev VO, Engelhardt S, Lohse MJ, Conti M, Fischmeister R, Vandecasteele G. Role of PDE3 and PDE4 for β-adrenergic control of cAMP and ICa,L in adult rat ventricular myocytes Journal of Molecular and Cellular Cardiology. 42: S49. DOI: 10.1016/J.Yjmcc.2007.03.139  0.635
2006 Lohse MJ. G protein-coupled receptors: too many dimers? Nature Methods. 3: 972-3. PMID 17117152 DOI: 10.1038/Nmeth1206-972  0.479
2006 Nikolaev VO, Bünemann M, Schmitteckert E, Lohse MJ, Engelhardt S. Cyclic AMP imaging in adult cardiac myocytes reveals far-reaching beta1-adrenergic but locally confined beta2-adrenergic receptor-mediated signaling. Circulation Research. 99: 1084-91. PMID 17038640 DOI: 10.1161/01.Res.0000250046.69918.D5  0.787
2006 Störk S, Boivin V, Horf R, Hein L, Lohse MJ, Angermann CE, Jahns R. Stimulating autoantibodies directed against the cardiac beta1-adrenergic receptor predict increased mortality in idiopathic cardiomyopathy. American Heart Journal. 152: 697-704. PMID 16996841 DOI: 10.1016/J.Ahj.2006.05.004  0.533
2006 Harbeck MC, Chepurny O, Nikolaev VO, Lohse MJ, Holz GG, Roe MW. Simultaneous optical measurements of cytosolic Ca2+ and cAMP in single cells. Science's Stke : Signal Transduction Knowledge Environment. 2006: pl6. PMID 16985238 DOI: 10.1126/Stke.3532006Pl6  0.558
2006 Hein P, Rochais F, Hoffmann C, Dorsch S, Nikolaev VO, Engelhardt S, Berlot CH, Lohse MJ, Bünemann M. Gs activation is time-limiting in initiating receptor-mediated signaling. The Journal of Biological Chemistry. 281: 33345-51. PMID 16963443 DOI: 10.1074/Jbc.M606713200  0.851
2006 Jahns R, Boivin V, Lohse MJ. Beta 1-adrenergic receptor-directed autoimmunity as a cause of dilated cardiomyopathy in rats. International Journal of Cardiology. 112: 7-14. PMID 16872696 DOI: 10.1016/J.Ijcard.2006.05.008  0.389
2006 Nikolaev VO, Hoffmann C, Bünemann M, Lohse MJ, Vilardaga JP. Molecular basis of partial agonism at the neurotransmitter alpha2A-adrenergic receptor and Gi-protein heterotrimer. The Journal of Biological Chemistry. 281: 24506-11. PMID 16787921 DOI: 10.1074/Jbc.M603266200  0.853
2006 Nikolaev VO, Lohse MJ. Monitoring of cAMP synthesis and degradation in living cells. Physiology (Bethesda, Md.). 21: 86-92. PMID 16565474 DOI: 10.1152/Physiol.00057.2005  0.599
2006 Klenk C, Humrich J, Quitterer U, Lohse MJ. SUMO-1 controls the protein stability and the biological function of phosducin. The Journal of Biological Chemistry. 281: 8357-64. PMID 16421094 DOI: 10.1074/Jbc.M513703200  0.691
2006 Jahns R, Boivin V, Lohse MJ. beta(1)-Adrenergic receptor function, autoimmunity, and pathogenesis of dilated cardiomyopathy. Trends in Cardiovascular Medicine. 16: 20-4. PMID 16387626 DOI: 10.1016/J.Tcm.2005.11.002  0.383
2006 Nikolaev VO, Gambaryan S, Lohse MJ. Fluorescent sensors for rapid monitoring of intracellular cGMP. Nature Methods. 3: 23-5. PMID 16369548 DOI: 10.1038/Nmeth816  0.552
2005 Vilardaga JP, Steinmeyer R, Harms GS, Lohse MJ. Molecular basis of inverse agonism in a G protein-coupled receptor. Nature Chemical Biology. 1: 25-8. PMID 16407989 DOI: 10.1038/Nchembio705  0.744
2005 Hein P, Frank M, Hoffmann C, Lohse MJ, Bünemann M. Dynamics of receptor/G protein coupling in living cells. The Embo Journal. 24: 4106-14. PMID 16292347 DOI: 10.1038/Sj.Emboj.7600870  0.797
2005 Castro M, Nikolaev VO, Palm D, Lohse MJ, Vilardaga JP. Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism. Proceedings of the National Academy of Sciences of the United States of America. 102: 16084-9. PMID 16236727 DOI: 10.1073/Pnas.0503942102  0.775
2005 Winstel R, Ihlenfeldt HG, Jung G, Krasel C, Lohse MJ. Peptide inhibitors of G protein-coupled receptor kinases. Biochemical Pharmacology. 70: 1001-8. PMID 16102734 DOI: 10.1016/J.Bcp.2005.06.015  0.423
2005 Buitrago M, Lorenz K, Maass AH, Oberdorf-Maass S, Keller U, Schmitteckert EM, Ivashchenko Y, Lohse MJ, Engelhardt S. The transcriptional repressor Nab1 is a specific regulator of pathological cardiac hypertrophy. Nature Medicine. 11: 837-44. PMID 16025126 DOI: 10.1038/Nm1272  0.693
2005 Landa LR, Harbeck M, Kaihara K, Chepurny O, Kitiphongspattana K, Graf O, Nikolaev VO, Lohse MJ, Holz GG, Roe MW. Interplay of Ca2+ and cAMP signaling in the insulin-secreting MIN6 beta-cell line. The Journal of Biological Chemistry. 280: 31294-302. PMID 15987680 DOI: 10.1074/Jbc.M505657200  0.504
2005 Frank M, Thümer L, Lohse MJ, Bünemann M. G Protein activation without subunit dissociation depends on a G{alpha}(i)-specific region. The Journal of Biological Chemistry. 280: 24584-90. PMID 15866880 DOI: 10.1074/Jbc.M414630200  0.661
2005 Hoffmann C, Gaietta G, Bünemann M, Adams SR, Oberdorff-Maass S, Behr B, Vilardaga JP, Tsien RY, Ellisman MH, Lohse MJ. A FlAsH-based FRET approach to determine G protein-coupled receptor activation in living cells. Nature Methods. 2: 171-6. PMID 15782185 DOI: 10.1038/Nmeth742  0.821
2005 Humrich J, Bermel C, Bünemann M, Härmark L, Frost R, Quitterer U, Lohse MJ. Phosducin-like protein regulates G-protein betagamma folding by interaction with tailless complex polypeptide-1alpha: dephosphorylation or splicing of PhLP turns the switch toward regulation of Gbetagamma folding. The Journal of Biological Chemistry. 280: 20042-50. PMID 15745879 DOI: 10.1074/Jbc.M409233200  0.771
2005 Frambach T, Müller T, Freund S, Engelhardt S, Sütterlin M, Lohse MJ, Dietl J. Self-limitation of intravenous tocolysis with beta2-adrenergic agonists is mediated through receptor G protein uncoupling. The Journal of Clinical Endocrinology and Metabolism. 90: 2882-7. PMID 15728216 DOI: 10.1210/Jc.2004-1732  0.686
2005 Krasel C, Bünemann M, Lorenz K, Lohse MJ. Beta-arrestin binding to the beta2-adrenergic receptor requires both receptor phosphorylation and receptor activation. The Journal of Biological Chemistry. 280: 9528-35. PMID 15634674 DOI: 10.1074/Jbc.M413078200  0.818
2005 Nikolaev VO, Gambaryan S, Engelhardt S, Walter U, Lohse MJ. Real-time monitoring of the PDE2 activity of live cells: hormone-stimulated cAMP hydrolysis is faster than hormone-stimulated cAMP synthesis. The Journal of Biological Chemistry. 280: 1716-9. PMID 15557342 DOI: 10.1074/Jbc.C400505200  0.694
2005 Boivin V, Hein L, Angermann CE, Palm D, ller JM, Ertl G, Lohse MJ, Jahns R. 104 A novel receptor‐homologous cyclic peptide prevents beta1‐adrenoceptor antibody‐induced progressive cardiomyopathy European Journal of Heart Failure Supplements. 4: 24-24. DOI: 10.1016/S1567-4215(05)80062-1  0.457
2005 Nikolaev VO, Lohse MJ. Visualization of cAMP in living cells | Visualisierung von cAMP in lebenden zellen Biospektrum. 11: 724-726.  0.468
2005 Hein P, Frank M, Lohse MJ, Bünemann M. Receptor/G-protein interaction in individual living cells | Rezeptor/G-Protein - Interaktion in einzelnen lebenden Zellen Biospektrum. 11: 331-332.  0.737
2004 Krasel C, Vilardaga JP, Bünemann M, Lohse MJ. Kinetics of G-protein-coupled receptor signalling and desensitization. Biochemical Society Transactions. 32: 1029-31. PMID 15506955 DOI: 10.1042/Bst0321029  0.823
2004 Witte K, Engelhardt S, Janssen BJ, Lohse M, Lemmer B. Circadian and short-term regulation of blood pressure and heart rate in transgenic mice with cardiac overexpression of the beta1-adrenoceptor. Chronobiology International. 21: 205-16. PMID 15332342 DOI: 10.1081/Cbi-120037801  0.512
2004 Nikolaev VO, Bünemann M, Hein L, Hannawacker A, Lohse MJ. Novel single chain cAMP sensors for receptor-induced signal propagation. The Journal of Biological Chemistry. 279: 37215-8. PMID 15231839 DOI: 10.1074/Jbc.C400302200  0.815
2004 Mongillo M, McSorley T, Evellin S, Sood A, Lissandron V, Terrin A, Huston E, Hannawacker A, Lohse MJ, Pozzan T, Houslay MD, Zaccolo M. Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases. Circulation Research. 95: 67-75. PMID 15178638 DOI: 10.1161/01.Res.0000134629.84732.11  0.441
2004 Jahns R, Boivin V, Hein L, Triebel S, Angermann CE, Ertl G, Lohse MJ. Direct evidence for a beta 1-adrenergic receptor-directed autoimmune attack as a cause of idiopathic dilated cardiomyopathy. The Journal of Clinical Investigation. 113: 1419-29. PMID 15146239 DOI: 10.1172/Jci20149  0.595
2004 Lohse MJ. Beta-adrenoceptor polymorphisms and heart failure. Trends in Molecular Medicine. 10: 55-8. PMID 15106619 DOI: 10.1016/J.Molmed.2003.12.004  0.374
2004 Foerster K, Kaeferstein T, Groner F, Engelhardt S, Matthes J, Koch WJ, Lohse MJ, Herzig S. Calcium channel function and regulation in beta 1- and beta 2-adrenoceptor transgenic mice. Naunyn-Schmiedeberg's Archives of Pharmacology. 369: 490-5. PMID 15083268 DOI: 10.1007/S00210-004-0928-3  0.552
2004 Kirchhefer U, Jones LR, Begrow F, Boknik P, Hein L, Lohse MJ, Riemann B, Schmitz W, Stypmann J, Neumann J. Transgenic triadin 1 overexpression alters SR Ca2+ handling and leads to a blunted contractile response to beta-adrenergic agonists. Cardiovascular Research. 62: 122-34. PMID 15023559 DOI: 10.1016/J.Cardiores.2004.01.005  0.556
2004 Engelhardt S, Hein L, Dyachenkow V, Kranias EG, Isenberg G, Lohse MJ. Altered calcium handling is critically involved in the cardiotoxic effects of chronic beta-adrenergic stimulation. Circulation. 109: 1154-60. PMID 14967726 DOI: 10.1161/01.Cir.0000117254.68497.39  0.662
2004 Hoffmann C, Leitz MR, Oberdorf-Maass S, Lohse MJ, Klotz KN. Comparative pharmacology of human beta-adrenergic receptor subtypes--characterization of stably transfected receptors in CHO cells. Naunyn-Schmiedeberg's Archives of Pharmacology. 369: 151-9. PMID 14730417 DOI: 10.1007/s00210-003-0860-y  0.363
2004 Freund S, Ungerer M, Lohse MJ. A1 adenosine receptors expressed in CHO-cells couple to adenylyl cyclase and to phospholipase C Naunyn-Schmiedeberg's Archives of Pharmacology. 350: 49-56. PMID 7935854 DOI: 10.1007/Bf00180010  0.471
2003 Lohse MJ, Vilardaga JP, Bünemann M. Molecular mechanisms of receptor activation: real-time analysis by fluorescence resonance energy transfer. Autonomic & Autacoid Pharmacology. 23: 231-3. PMID 15134067  0.744
2003 Bünemann M, Frank M, Lohse MJ. Gi protein activation in intact cells involves subunit rearrangement rather than dissociation. Proceedings of the National Academy of Sciences of the United States of America. 100: 16077-82. PMID 14673086 DOI: 10.1073/Pnas.2536719100  0.702
2003 Lorenz K, Lohse MJ, Quitterer U. Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2. Nature. 426: 574-9. PMID 14654844 DOI: 10.1038/Nature02158  0.825
2003 Gaussin V, Tomlinson JE, Depre C, Engelhardt S, Antos CL, Takagi G, Hein L, Topper JN, Liggett SB, Olson EN, Lohse MJ, Vatner SF, Vatner DE. Common genomic response in different mouse models of beta-adrenergic-induced cardiomyopathy. Circulation. 108: 2926-33. PMID 14623810 DOI: 10.1161/01.Cir.0000101922.18151.7B  0.689
2003 Lohse MJ, Engelhardt S, Eschenhagen T. What is the role of beta-adrenergic signaling in heart failure? Circulation Research. 93: 896-906. PMID 14615493 DOI: 10.1161/01.Res.0000102042.83024.Ca  0.608
2003 Lohse MJ, Vilardaga JP, Bünemann M. Direct optical recording of intrinsic efficacy at a G protein-coupled receptor. Life Sciences. 74: 397-404. PMID 14607268 DOI: 10.1016/J.Lfs.2003.09.026  0.821
2003 Paris A, Philipp M, Tonner PH, Steinfath M, Lohse M, Scholz J, Hein L. Activation of alpha 2B-adrenoceptors mediates the cardiovascular effects of etomidate. Anesthesiology. 99: 889-95. PMID 14508322 DOI: 10.1097/00000542-200310000-00022  0.588
2003 Eigenthaler M, Engelhardt S, Schinke B, Kobsar A, Schmitteckert E, Gambaryan S, Engelhardt CM, Krenn V, Eliava M, Jarchau T, Lohse MJ, Walter U, Hein L. Disruption of cardiac Ena-VASP protein localization in intercalated disks causes dilated cardiomyopathy. American Journal of Physiology. Heart and Circulatory Physiology. 285: H2471-81. PMID 12933343 DOI: 10.1152/Ajpheart.00362.2003  0.652
2003 Li Z, Laugwitz KL, Pinkernell K, Pragst I, Baumgartner C, Hoffmann E, Rosport K, Münch G, Moretti A, Humrich J, Lohse MJ, Ungerer M. Effects of two Gbetagamma-binding proteins--N-terminally truncated phosducin and beta-adrenergic receptor kinase C terminus (betaARKct)--in heart failure. Gene Therapy. 10: 1354-61. PMID 12883532 DOI: 10.1038/Sj.Gt.3301995  0.428
2003 Maack C, Böhm M, Vlaskin L, Dabew E, Lorenz K, Schäfers HJ, Lohse MJ, Engelhardt S. Partial agonist activity of bucindolol is dependent on the activation state of the human beta1-adrenergic receptor. Circulation. 108: 348-53. PMID 12847069 DOI: 10.1161/01.Cir.0000080325.94345.8B  0.743
2003 Vilardaga JP, Bünemann M, Krasel C, Castro M, Lohse MJ. Measurement of the millisecond activation switch of G protein-coupled receptors in living cells. Nature Biotechnology. 21: 807-12. PMID 12808462 DOI: 10.1038/Nbt838  0.813
2003 Brede M, Nagy G, Philipp M, Sorensen JB, Lohse MJ, Hein L. Differential control of adrenal and sympathetic catecholamine release by alpha 2-adrenoceptor subtypes. Molecular Endocrinology (Baltimore, Md.). 17: 1640-6. PMID 12764077 DOI: 10.1210/Me.2003-0035  0.534
2003 Spindler M, Engelhardt S, Niebler R, Wagner H, Hein L, Lohse MJ, Neubauer S. Alterations in the myocardial creatine kinase system precede the development of contractile dysfunction in beta(1)-adrenergic receptor transgenic mice. Journal of Molecular and Cellular Cardiology. 35: 389-97. PMID 12689818 DOI: 10.1016/S0022-2828(03)00015-4  0.678
2003 Hessling J, Lohse MJ, Klotz KN. Peptide G protein agonists from a phage display library. Biochemical Pharmacology. 65: 961-7. PMID 12623127 DOI: 10.1016/S0006-2952(02)01653-2  0.406
2003 Eichmann T, Lorenz K, Hoffmann M, Brockmann J, Krasel C, Lohse MJ, Quitterer U. The amino-terminal domain of G-protein-coupled receptor kinase 2 is a regulatory Gbeta gamma binding site. The Journal of Biological Chemistry. 278: 8052-7. PMID 12486133 DOI: 10.1074/Jbc.M204795200  0.799
2003 Humrich J, Bermel C, Grubel T, Quitterer U, Lohse MJ. Regulation of phosducin-like protein by casein kinase 2 and N-terminal splicing. The Journal of Biological Chemistry. 278: 4474-81. PMID 12466282 DOI: 10.1074/Jbc.M206347200  0.668
2003 Hommers LG, Lohse MJ, Bünemann M. Regulation of the inward rectifying properties of G-protein-activated inwardly rectifying K+ (GIRK) channels by Gbeta gamma subunits. The Journal of Biological Chemistry. 278: 1037-43. PMID 12403784 DOI: 10.1074/Jbc.M205325200  0.601
2003 ENGELHARDT S, HEIN L, KRANIAS E, LOHSE M. 682 Phospholamban is critically involved in beta-adrenergic receptor induced cardiac hypertrophy and failure European Journal of Heart Failure Supplements. 2: 140-141. DOI: 10.1016/S1567-4215(03)90427-9  0.703
2002 Hannawacker A, Krasel C, Lohse MJ. Mutation of Asn293 to Asp in transmembrane helix VI abolishes agonist-induced but not constitutive activity of the beta(2)-adrenergic receptor. Molecular Pharmacology. 62: 1431-7. PMID 12435811 DOI: 10.1124/Mol.62.6.1431  0.52
2002 Brede M, Wiesmann F, Jahns R, Hadamek K, Arnolt C, Neubauer S, Lohse MJ, Hein L. Feedback inhibition of catecholamine release by two different alpha2-adrenoceptor subtypes prevents progression of heart failure. Circulation. 106: 2491-6. PMID 12417548 DOI: 10.1161/01.Cir.0000036600.39600.66  0.516
2002 Castro M, Dicker F, Vilardaga JP, Krasel C, Bernhardt M, Lohse MJ. Dual regulation of the parathyroid hormone (PTH)/PTH-related peptide receptor signaling by protein kinase C and beta-arrestins. Endocrinology. 143: 3854-65. PMID 12239097 DOI: 10.1210/En.2002-220232  0.714
2002 Michaelevski I, Chikvashvili D, Tsuk S, Fili O, Lohse MJ, Singer-Lahat D, Lotan I. Modulation of a brain voltage-gated K+ channel by syntaxin 1A requires the physical interaction of Gbetagamma with the channel. The Journal of Biological Chemistry. 277: 34909-17. PMID 12114518 DOI: 10.1074/Jbc.M203943200  0.325
2002 Vetter T, Lohse MJ. Magnesium and the parathyroid. Current Opinion in Nephrology and Hypertension. 11: 403-10. PMID 12105390 DOI: 10.1097/00041552-200207000-00006  0.314
2002 Philipp M, Brede ME, Hadamek K, Gessler M, Lohse MJ, Hein L. Placental alpha(2)-adrenoceptors control vascular development at the interface between mother and embryo. Nature Genetics. 31: 311-5. PMID 12068299 DOI: 10.1038/Ng919  0.498
2002 Engelhardt S, Hein L, Keller U, Klämbt K, Lohse MJ. Inhibition of Na(+)-H(+) exchange prevents hypertrophy, fibrosis, and heart failure in beta(1)-adrenergic receptor transgenic mice. Circulation Research. 90: 814-9. PMID 11964375 DOI: 10.1161/01.Res.0000014966.97486.C0  0.701
2002 Vilardaga JP, Krasel C, Chauvin S, Bambino T, Lohse MJ, Nissenson RA. Internalization determinants of the parathyroid hormone receptor differentially regulate beta-arrestin/receptor association. The Journal of Biological Chemistry. 277: 8121-9. PMID 11726668 DOI: 10.1074/Jbc.M110433200  0.721
2001 Lohse MJ, Engelhardt S. Protein kinase a transgenes: the many faces of cAMP. Circulation Research. 89: 938-40. PMID 11717148 DOI: 10.1161/Res.89.11.938  0.649
2001 Brede M, Hadamek K, Meinel L, Wiesmann F, Peters J, Engelhardt S, Simm A, Haase A, Lohse MJ, Hein L. Vascular hypertrophy and increased P70S6 kinase in mice lacking the angiotensin II AT(2) receptor. Circulation. 104: 2602-7. PMID 11714657 DOI: 10.1161/Hc4601.099401  0.687
2001 Scheel AA, Funsch B, Busch M, Gradl G, Pschorr J, Lohse MJ. Receptor-ligand interactions studied with homogeneous fluorescence-based assays suitable for miniaturized screening. Journal of Biomolecular Screening. 6: 11-8. PMID 11679161 DOI: 10.1177/108705710100600103  0.45
2001 Chruscinski A, Brede ME, Meinel L, Lohse MJ, Kobilka BK, Hein L. Differential distribution of beta-adrenergic receptor subtypes in blood vessels of knockout mice lacking beta(1)- or beta(2)-adrenergic receptors. Molecular Pharmacology. 60: 955-62. PMID 11641423 DOI: 10.1124/Mol.60.5.955  0.668
2001 Engelhardt S, Boknik P, Keller U, Neumann J, Lohse MJ, Hein L. Early impairment of calcium handling and altered expression of junctin in hearts of mice overexpressing the beta1-adrenergic receptor. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 15: 2718-20. PMID 11606476 DOI: 10.1096/Fj.01-0107Fje  0.713
2001 Bünemann M, Bücheler MM, Philipp M, Lohse MJ, Hein L. Activation and deactivation kinetics of alpha 2A- and alpha 2C-adrenergic receptor-activated G protein-activated inwardly rectifying K+ channel currents. The Journal of Biological Chemistry. 276: 47512-7. PMID 11591725 DOI: 10.1074/Jbc.M108652200  0.74
2001 Engelhardt S, Grimmer Y, Fan GH, Lohse MJ. Constitutive activity of the human beta(1)-adrenergic receptor in beta(1)-receptor transgenic mice. Molecular Pharmacology. 60: 712-7. PMID 11562432  0.58
2001 Vilardaga JP, Frank M, Krasel C, Dees C, Nissenson RA, Lohse MJ. Differential conformational requirements for activation of G proteins and the regulatory proteins arrestin and G protein-coupled receptor kinase in the G protein-coupled receptor for parathyroid hormone (PTH)/PTH-related protein. The Journal of Biological Chemistry. 276: 33435-43. PMID 11387315 DOI: 10.1074/Jbc.M011495200  0.723
2001 Wiesmann F, Ruff J, Engelhardt S, Hein L, Dienesch C, Leupold A, Illinger R, Frydrychowicz A, Hiller KH, Rommel E, Haase A, Lohse MJ, Neubauer S. Dobutamine-stress magnetic resonance microimaging in mice : acute changes of cardiac geometry and function in normal and failing murine hearts. Circulation Research. 88: 563-9. PMID 11282889 DOI: 10.1161/01.Res.88.6.563  0.633
2001 Kaumann AJ, Engelhardt S, Hein L, Molenaar P, Lohse M. Abolition of (-)-CGP 12177-evoked cardiostimulation in double β1/β2-adrenoceptor knockout mice. Obligatory role of β1-adrenoceptors for putative β4-adrenoceptor pharmacology Naunyn-Schmiedeberg's Archives of Pharmacology. 363: 87-93. PMID 11191841 DOI: 10.1007/S002100000336  0.654
2001 Boivin V, Jahns R, Gambaryan S, Ness W, Boege F, Lohse MJ. Immunofluorescent imaging of beta 1- and beta 2-adrenergic receptors in rat kidney. Kidney International. 59: 515-31. PMID 11168934 DOI: 10.1046/J.1523-1755.2001.059002515.X  0.35
2001 Quitterer U, Hoffmann M, Freichel M, Lohse MJ. Paradoxical block of parathormone secretion is mediated by increased activity of G alpha subunits. The Journal of Biological Chemistry. 276: 6763-9. PMID 11102444 DOI: 10.1074/jbc.M007727200  0.702
2001 Krasel C, Dammeier S, Winstel R, Brockmann J, Mischak H, Lohse MJ. Phosphorylation of GRK2 by protein kinase C abolishes its inhibition by calmodulin. The Journal of Biological Chemistry. 276: 1911-5. PMID 11042191 DOI: 10.1074/Jbc.M008773200  0.413
2000 Schröder S, Lohse MJ. Quantification of the tissue levels and function of the G-protein regulator phosducin-like protein (PhlP). Naunyn-Schmiedeberg's Archives of Pharmacology. 362: 435-9. PMID 11111839 DOI: 10.1007/S002100000298  0.361
2000 Illes P, Klotz KN, Lohse MJ. Signaling by extracellular nucleotides and nucleosides. Naunyn-Schmiedeberg's Archives of Pharmacology. 362: 295-8. PMID 11111824 DOI: 10.1007/S002100000308  0.309
2000 Hammerschmidt S, Bell M, Büchler N, Wahn H, Remkes H, Lohse MJ, Neubauer S. Acute changes of myocardial creatine kinase gene expression under beta-adrenergic stimulation. Biochimica Et Biophysica Acta. 1502: 471-80. PMID 11068189 DOI: 10.1016/S0925-4439(00)00070-3  0.317
2000 Jahns R, Boivin V, Krapf T, Wallukat G, Boege F, Lohse MJ. Modulation of beta1-adrenoceptor activity by domain-specific antibodies and heart failure-associated autoantibodies. Journal of the American College of Cardiology. 36: 1280-7. PMID 11028484 DOI: 10.1016/S0735-1097(00)00881-0  0.373
2000 Ruiz-Gómez A, Humrich J, Murga C, Quitterer U, Lohse MJ, Mayor F. Phosphorylation of phosducin and phosducin-like protein by G protein-coupled receptor kinase 2. The Journal of Biological Chemistry. 275: 29724-30. PMID 10884381 DOI: 10.1074/Jbc.M001864200  0.749
2000 Brambilla R, Cattabeni F, Ceruti S, Barbieri D, Franceschi C, Kim YC, Jacobson KA, Klotz KN, Lohse MJ, Abbracchio MP. Activation of the A3 adenosine receptor affects cell cycle progression and cell growth. Naunyn-Schmiedeberg's Archives of Pharmacology. 361: 225-34. PMID 10731034 DOI: 10.1007/S002109900186  0.526
2000 Engelhardt S, Lohse MJ. Determination of adrenergic receptor mRNAs by quantitative reverse transcriptase-polymerase chain reactions. Methods in Molecular Biology (Clifton, N.J.). 126: 155-68. PMID 10685408 DOI: 10.1385/1-59259-684-3:155  0.567
1999 Jahns R, Boivin V, Siegmund C, Boege F, Lohse MJ, Inselmann G. Activating beta-1-adrenoceptor antibodies are not associated with cardiomyopathies secondary to valvular or hypertensive heart disease. Journal of the American College of Cardiology. 34: 1545-51. PMID 10551705 DOI: 10.1016/S0735-1097(99)00381-2  0.346
1999 Zuurmond HM, Hessling J, Blüml K, Lohse M, Ijzerman AP. Study of interaction between agonists and Asn293 in helix VI of human β2-adrenergic receptor Molecular Pharmacology. 56: 909-916. PMID 10531394 DOI: 10.1124/Mol.56.5.909  0.445
1999 Slupsky JR, Quitterer U, Weber CK, Gierschik P, Lohse MJ, Rapp UR. Binding of Gbetagamma subunits to cRaf1 downregulates G-protein-coupled receptor signalling. Current Biology : Cb. 9: 971-4. PMID 10508586 DOI: 10.1016/S0960-9822(99)80426-6  0.762
1999 Quitterer U, Lohse MJ. Crosstalk between Galpha(i)- and Galpha(q)-coupled receptors is mediated by Gbetagamma exchange. Proceedings of the National Academy of Sciences of the United States of America. 96: 10626-31. PMID 10485876 DOI: 10.1073/Pnas.96.19.10626  0.771
1999 Lohse MJ. G-Proteins and their regulators. Naunyn-Schmiedeberg's Archives of Pharmacology. 360: 3-4. PMID 10463327 DOI: 10.1007/S002109900029  0.351
1999 Engelhardt S, Hein L, Wiesmann F, Lohse MJ. Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 96: 7059-64. PMID 10359838 DOI: 10.1073/Pnas.96.12.7059  0.694
1999 Dicker F, Quitterer U, Winstel R, Honold K, Lohse MJ. Phosphorylation-independent inhibition of parathyroid hormone receptor signaling by G protein-coupled receptor kinases. Proceedings of the National Academy of Sciences of the United States of America. 96: 5476-81. PMID 10318908 DOI: 10.1073/Pnas.96.10.5476  0.782
1999 Jahns R, Boivin V, Siegmund C, Inselmann G, Lohse MJ, Boege F. Autoantibodies activating human beta1-adrenergic receptors are associated with reduced cardiac function in chronic heart failure. Circulation. 99: 649-54. PMID 9950662 DOI: 10.1161/01.Cir.99.5.649  0.423
1999 Danner S, Lohse MJ. Regulation of beta-adrenergic receptor responsiveness modulation of receptor gene expression. Reviews of Physiology, Biochemistry and Pharmacology. 136: 183-223. PMID 9932487  0.346
1998 Lohse MJ, Förstermann U, Schmidt HH. Pharmacology of NO:cGMP signal transduction. Naunyn-Schmiedeberg's Archives of Pharmacology. 358: 111-2. PMID 9721011 DOI: 10.1007/Pl00005230  0.312
1998 Bauer PH, Lohse MJ. Effects of phosducin on the GTPase cycle of Go. Naunyn-Schmiedeberg's Archives of Pharmacology. 357: 371-7. PMID 9606021 DOI: 10.1007/Pl00005181  0.395
1998 Bauer PH, Blüml K, Schröder S, Hegler J, Dees C, Lohse MJ. Interactions of phosducin with the subunits of G-proteins. Binding to the alpha as well as the betagamma subunits. The Journal of Biological Chemistry. 273: 9465-71. PMID 9545273 DOI: 10.1074/Jbc.273.16.9465  0.378
1998 Klotz KN, Hessling J, Hegler J, Owman C, Kull B, Fredholm BB, Lohse MJ. Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells. Naunyn-Schmiedeberg's Archives of Pharmacology. 357: 1-9. PMID 9459566 DOI: 10.1007/Pl00005131  0.493
1998 Danner S, Frank M, Lohse MJ. Agonist regulation of human beta2-adrenergic receptor mRNA stability occurs via a specific AU-rich element. The Journal of Biological Chemistry. 273: 3223-9. PMID 9452435 DOI: 10.1074/Jbc.273.6.3223  0.445
1997 Schwab KO, Gerlich M, Broecker M, Söhlemann P, Derwahl M, Lohse MJ. Constitutively active germline mutation of the thyrotropin receptor gene as a cause of congenital hyperthyroidism. The Journal of Pediatrics. 131: 899-904. PMID 9427897 DOI: 10.1016/S0022-3476(97)70040-4  0.377
1997 Gabilondo AM, Hegler J, Krasel C, Boivin-Jahns V, Hein L, Lohse MJ. A dileucine motif in the C terminus of the beta2-adrenergic receptor is involved in receptor internalization. Proceedings of the National Academy of Sciences of the United States of America. 94: 12285-90. PMID 9356441 DOI: 10.1073/Pnas.94.23.12285  0.68
1997 Jahns R, Siegmund C, Jahns V, Reiländer H, Maidhof A, Müller-Esterl W, Lohse MJ, Boege F. Probing human beta1- and beta2 -adrenoceptors with domain-specific fusion protein antibodies. European Journal of Pharmacology. 334: 115-26. PMID 9346338 DOI: 10.1016/S0014-2999(97)80346-9  0.398
1997 Blüml K, Schnepp W, Schröder S, Beyermann M, Macias M, Oschkinat H, Lohse MJ. A small region in phosducin inhibits G-protein betagamma-subunit function. The Embo Journal. 16: 4908-15. PMID 9305633 DOI: 10.1093/Emboj/16.16.4908  0.347
1997 Danner S, Lohse MJ. Cell type-specific regulation of beta2-adrenoceptor mRNA by agonists. European Journal of Pharmacology. 331: 73-8. PMID 9274932 DOI: 10.1016/S0014-2999(97)01022-4  0.347
1997 Engelhardt S, Zieger W, Kassubek J, Michel MC, Lohse MJ, Brodde OE. Tocolytic therapy with fenoterol induces selective down-regulation of beta-adrenergic receptors in human myometrium. The Journal of Clinical Endocrinology and Metabolism. 82: 1235-42. PMID 9100601 DOI: 10.1210/Jcem.82.4.3885  0.638
1997 Söhlemann P, Soppa J, Oesterhelt D, Lohse MJ. Expression of beta 2-adrenoceptors in halobacteria. Naunyn-Schmiedeberg's Archives of Pharmacology. 355: 150-60. PMID 9050006 DOI: 10.1007/Pl00004926  0.421
1997 Boekhoff I, Touhara K, Danner S, Inglese J, Lohse MJ, Breer H, Lefkowitz RJ. Phosducin, potential role in modulation of olfactory signaling. The Journal of Biological Chemistry. 272: 4606-12. PMID 9020189 DOI: 10.1074/Jbc.272.7.4606  0.565
1997 Schröder S, Blüml K, Dees C, Lohse MJ. Identification of a C-terminal binding site for G-protein betagamma-subunits in phosducin-like protein. Febs Letters. 401: 243-6. PMID 9013896 DOI: 10.1016/S0014-5793(96)01483-4  0.408
1997 Müller S, Straub A, Lohse MJ. Selectivity of beta-adrenergic receptor kinase 2 for G protein betagamma subunits. Febs Letters. 401: 25-9. PMID 9003799 DOI: 10.1016/S0014-5793(96)01424-X  0.453
1997 Krasel C, Lohse MJ. Signalling in the β-adrenergic receptor system Pharmacochemistry Library. 28: 317-327. DOI: 10.1016/S0165-7208(97)80075-X  0.45
1996 Lohse MJ, Bluml K, Danner S, Krasel C. Regulators of G-protein-mediated signalling Biochemical Society Transactions. 24: 975-980. PMID 8968495 DOI: 10.1042/Bst0240975  0.389
1996 Lohse MJ, Engelhardt S, Danner S, Böhm M. Mechanisms of beta-adrenergic receptor desensitization: from molecular biology to heart failure. Basic Research in Cardiology. 91: 29-34. PMID 8957541 DOI: 10.1007/Bf00795359  0.694
1996 Blaukat A, Alla SA, Lohse MJ, Müller-Esterl W. Ligand-induced phosphorylation/dephosphorylation of the endogenous bradykinin B2 receptor from human fibroblasts. The Journal of Biological Chemistry. 271: 32366-74. PMID 8943300 DOI: 10.1074/Jbc.271.50.32366  0.484
1996 Gabilondo AM, Krasel C, Lohse MJ. Mutations of Tyr326 in the β2-adrenoceptor disrupt multiple receptor functions European Journal of Pharmacology. 307: 243-250. PMID 8832227 DOI: 10.1016/0014-2999(96)00247-6  0.518
1996 Danner S, Lohse MJ. Phosducin is a ubiquitous G-protein regulator Proceedings of the National Academy of Sciences of the United States of America. 93: 10145-10150. PMID 8816766 DOI: 10.1073/Pnas.93.19.10145  0.393
1996 Wieland K, Zuurmond HM, Krasel C, Ijzerman AP, Lohse MJ. Involvement of Asn-293 in stereospecific agonist recognition and in activation of the beta 2-adrenergic receptor. Proceedings of the National Academy of Sciences of the United States of America. 93: 9276-81. PMID 8799191 DOI: 10.1073/Pnas.93.17.9276  0.493
1996 Schulz K, Danner S, Bauer P, Schröder S, Lohse MJ. Expression of phosducin in a phosducin-negative cell line reveals functions of a Gbetagamma-binding protein. The Journal of Biological Chemistry. 271: 22546-51. PMID 8798422 DOI: 10.1074/Jbc.271.37.22546  0.514
1996 Ungerer M, Kessebohm K, Kronsbein K, Lohse MJ, Richardt G. Activation of beta-adrenergic receptor kinase during myocardial ischemia. Circulation Research. 79: 455-60. PMID 8781479 DOI: 10.1161/01.Res.79.3.455  0.422
1996 Winstel R, Freund S, Krasel C, Hoppe E, Lohse MJ. Protein kinase cross-talk: membrane targeting of the beta-adrenergic receptor kinase by protein kinase C. Proceedings of the National Academy of Sciences of the United States of America. 93: 2105-9. PMID 8700892 DOI: 10.1073/Pnas.93.5.2105  0.478
1996 Schröder S, Lohse MJ. Inhibition of G-protein βγ-subunit functions by phosducin-like protein Proceedings of the National Academy of Sciences of the United States of America. 93: 2100-2104. PMID 8700891 DOI: 10.1073/Pnas.93.5.2100  0.396
1996 Lohse MJ, Krasel C, Winstel R, Mayor F. G-protein-coupled receptor kinases. Kidney International. 49: 1047-52. PMID 8691724 DOI: 10.1038/Ki.1996.153  0.562
1996 Müller S, Straub A, Schröder S, Bauer PH, Lohse MJ. Interactions of phosducin with defined G protein βγ-subunits Journal of Biological Chemistry. 271: 11781-11786. PMID 8662655 DOI: 10.1074/Jbc.271.20.11781  0.39
1996 Engelhardt S, Böhm M, Erdmann E, Lohse MJ. Analysis of beta-adrenergic receptor mRNA levels in human ventricular biopsy specimens by quantitative polymerase chain reactions: progressive reduction of beta 1-adrenergic receptor mRNA in heart failure. Journal of the American College of Cardiology. 27: 146-54. PMID 8522688 DOI: 10.1016/0735-1097(95)00425-4  0.602
1996 Lohse MJ. REGULATION OF G-PROTEIN-MEDIATED SIGNALLING BY REGULATORY PROTEINS Biochemical Society Transactions. 24: 575S-575S. DOI: 10.1042/Bst024575Sb  0.387
1996 Klotz KN, Jesaitis AJ, Lohse MJ. Mechanisms regulating G protein-coupled receptors Pharmacochemistry Library. 24: 11-25. DOI: 10.1016/S0165-7208(96)80004-3  0.514
1995 Muller S, Lohse MJ. The role of G-protein βγ subunits in signal transduction Biochemical Society Transactions. 23: 141-148. PMID 7758707 DOI: 10.1042/Bst0230141  0.397
1995 Pippig S, Andexinger S, Lohse MJ. Sequestration and recycling of beta 2-adrenergic receptors permit receptor resensitization. Molecular Pharmacology. 47: 666-76. PMID 7723728  0.786
1995 Söhlemann P, Hekman M, Puzicha M, Buchen C, Lohse MJ. Binding of Purified Recombinant β‐arrestin to Guanine‐Nucleotide‐Binding‐Protein‐Coupled Receptors Febs Journal. 232: 464-472. DOI: 10.1111/J.1432-1033.1995.464Zz.X  0.45
1995 Lohse MJ. G-protein-coupled receptor kinases and the heart Trends in Cardiovascular Medicine. 5: 63-68. DOI: 10.1016/1050-1738(94)00034-4  0.537
1995 Lohse M, Söhlemann P. Pharmacology of G-protein-coupled receptors in engineered cells Pharmacological Research. 31: 17. DOI: 10.1016/1043-6618(95)86329-X  0.344
1994 Ungerer M, Parruti G, Böhm M, Puzicha M, DeBlasi A, Erdmann E, Lohse MJ. Expression of beta-arrestins and beta-adrenergic receptor kinases in the failing human heart. Circulation Research. 74: 206-13. PMID 8293560 DOI: 10.1161/01.Res.74.2.206  0.34
1994 Hekman M, Bauer PH, Söhlemann P, Lohse MJ. Phosducin inhibits receptor phosphorylation by the β-adrenergic receptor kinase in a PKA-regulated manner Febs Letters. 343: 120-124. PMID 8168616 DOI: 10.1016/0014-5793(94)80302-1  0.534
1994 Häfner S, Adler HS, Mischak H, Janosch P, Heidecker G, Wolfman A, Pippig S, Lohse M, Ueffing M, Kolch W. Mechanism of inhibition of Raf-1 by protein kinase A. Molecular and Cellular Biology. 14: 6696-703. PMID 7935389 DOI: 10.1128/Mcb.14.10.6696  0.721
1994 Pei G, Samama P, Lohse M, Wang M, Codina J, Lefkowitz RJ. A constitutively active mutant beta 2-adrenergic receptor is constitutively desensitized and phosphorylated. Proceedings of the National Academy of Sciences of the United States of America. 91: 2699-702. PMID 7908440 DOI: 10.1073/Pnas.91.7.2699  0.62
1993 Sohlemann P, Hekman M, Buchen C, Elce JS, Lohse MJ. Purification and functional characterization of β‐adrenergic receptor kinase expressed in insect cells Febs Letters. 324: 59-62. PMID 8504860 DOI: 10.1016/0014-5793(93)81532-5  0.438
1993 Pippig S, Andexinger S, Daniel K, Puzicha M, Caron MG, Lefkowitz RJ, Lohse MJ. Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors. The Journal of Biological Chemistry. 268: 3201-8. PMID 8381421  0.781
1993 Ungerer M, Böhm M, Elce JS, Erdmann E, Lohse MJ. Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart. Circulation. 87: 454-63. PMID 8381058 DOI: 10.1161/01.Cir.87.2.454  0.469
1993 Müller S, Hekman M, Lohse MJ. Specific enhancement of β-adrenergic receptor kinase activity by defined G-protein β and γ subunits Proceedings of the National Academy of Sciences of the United States of America. 90: 10439-10443. PMID 8248128 DOI: 10.1073/Pnas.90.22.10439  0.428
1993 Lohse MJ. Molecular mechanisms of membrane receptor desensitization Bba - Molecular Cell Research. 1179: 171-188. PMID 7692969 DOI: 10.1016/0167-4889(93)90139-G  0.387
1993 Lohse MJ, Strasser RH, Helmreich EJM. Chapter 5 The β-adrenoceptors New Comprehensive Biochemistry. 24: 137-180. DOI: 10.1016/S0167-7306(08)60358-0  0.461
1992 Cristalli G, Eleuteri A, Vittori S, Volpini R, Lohse MJ, Klotz KN. 2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors. Journal of Medicinal Chemistry. 35: 2363-8. PMID 1619615 DOI: 10.1021/Jm00091A003  0.329
1992 Ungerer M, Obermaier-Skrobranek B, Lohse MJ. Adenosine A1 receptor gene structure and regulation in normotensive and spontaneously hypertensive rats European Journal of Pharmacology: Molecular Pharmacology. 226: 381-382. PMID 1397063 DOI: 10.1016/0922-4106(92)90058-4  0.331
1992 Ott I, Lohse MJ, Klotz KN, Vogt-Moykopf I, Schwabe U. Effects of adenosine on histamine release from human lung fragments. International Archives of Allergy and Immunology. 98: 50-6. PMID 1378041 DOI: 10.1159/000236163  0.546
1992 Lohse MJ, Andexinger S, Pitcher J, Trukawinski S, Codina J, Faure JP, Caron MG, Lefkowitz RJ. Receptor-specific desensitization with purified proteins. Kinase dependence and receptor specificity of beta-arrestin and arrestin in the beta 2-adrenergic receptor and rhodopsin systems. The Journal of Biological Chemistry. 267: 8558-64. PMID 1349018  0.549
1992 Pitcher J, Lohse MJ, Codina J, Caron MG, Lefkowitz RJ. Desensitization of the isolated beta 2-adrenergic receptor by beta-adrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular mechanisms. Biochemistry. 31: 3193-7. PMID 1348186 DOI: 10.1021/Bi00127A021  0.58
1992 Lohse MJ. Stable overexpression of human β2-adrenergic receptors in mammalian cells Naunyn-Schmiedeberg's Archives of Pharmacology. 345: 444-451. PMID 1320210 DOI: 10.1007/Bf00176623  0.465
1992 Bauer PH, Müller S, Puzicha M, Pippig S, Obermaier B, Helmreich EJ, Lohse MJ. Phosducin is a protein kinase A-regulated G-protein regulator. Nature. 358: 73-6. PMID 1319556 DOI: 10.1038/358073A0  0.786
1991 Lohse MJ, Klotz KN, Schwabe U. Mechanism of A2 adenosine receptor activation. I. Blockade of A2 adenosine receptors by photoaffinity labeling. Molecular Pharmacology. 39: 517-23. PMID 2017151  0.612
1991 Collins S, Lohse MJ, O'Dowd B, Caron MG, Lefkowitz RJ. Structure and regulation of G protein-coupled receptors: the beta 2-adrenergic receptor as a model. Vitamins and Hormones. 46: 1-39. PMID 1660639 DOI: 10.1016/S0083-6729(08)60681-0  0.645
1991 Roth NS, Campbell PT, Caron MG, Lefkowitz RJ, Lohse MJ. Comparative rates of desensitization of beta-adrenergic receptors by the beta-adrenergic receptor kinase and the cyclic AMP-dependent protein kinase. Proceedings of the National Academy of Sciences of the United States of America. 88: 6201-4. PMID 1648731 DOI: 10.1073/Pnas.88.14.6201  0.598
1991 Benovic J, Onorato J, Arriza J, Stone W, Lohse M, Jenkins N, Gilbert D, Copeland N, Caron M, Lefkowitz R. Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family Journal of Biological Chemistry. 266: 14939-14946. DOI: 10.1016/s0021-9258(18)98568-6  0.312
1990 Weber RG, Jones CR, Lohse MJ, Palacios JM. Autoradiographic visualization of A1 adenosine receptors in rat brain with [3H]8-cyclopentyl-1,3-dipropylxanthine. Journal of Neurochemistry. 54: 1344-53. PMID 2313291 DOI: 10.1111/J.1471-4159.1990.Tb01968.X  0.64
1990 Collins S, Bouvier M, Lohse MJ, Benovic JL, Caron MG, Lefkowitz RJ. Mechanisms involved in adrenergic receptor desensitization. Biochemical Society Transactions. 18: 541-4. PMID 2177406 DOI: 10.1042/Bst0180541  0.735
1990 Benovic JL, Onorato J, Lohse MJ, Dohlman HG, Staniszewski C, Caron MG, Lefkowitz RJ. Synthetic peptides of the hamster beta 2-adrenoceptor as substrates and inhibitors of the beta-adrenoceptor kinase. British Journal of Clinical Pharmacology. 30: 3S-12S. PMID 2176526 DOI: 10.1111/J.1365-2125.1990.Tb05462.X  0.528
1990 Lohse MJ, Benovic JL, Codina J, Caron MG, Lefkowitz RJ. beta-Arrestin: a protein that regulates beta-adrenergic receptor function. Science (New York, N.Y.). 248: 1547-50. PMID 2163110 DOI: 10.1126/Science.2163110  0.568
1990 Lohse MJ, Benovic JL, Caron MG, Lefkowitz RJ. Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors. The Journal of Biological Chemistry. 265: 3202-11. PMID 2154473  0.535
1990 Hausdorff WP, Lohse MJ, Bouvier M, Liggett SB, Caron MG, Lefkowitz RJ. Two kinases mediate agonist-dependent phosphorylation and desensitization of the beta 2-adrenergic receptor. Symposia of the Society For Experimental Biology. 44: 225-40. PMID 1983369  0.665
1989 Böhm M, Beuckelmann D, Diet F, Feiler G, Lohse MJ, Erdmann E. Properties of cardiac alpha- and beta-adrenoceptors in spontaneously hypertensive rats. Naunyn-Schmiedeberg's Archives of Pharmacology. 338: 383-91. PMID 2854206 DOI: 10.1007/Bf00172114  0.339
1989 Reddington M, Klotz KN, Lohse MJ, Hietel B. Radiation inactivation analysis of the A1 adenosine receptor of rat brain. Decrease in radiation inactivation size in the presence of guanine nucleotide. Febs Letters. 252: 125-8. PMID 2759228 DOI: 10.1016/0014-5793(89)80903-2  0.392
1989 Klotz KN, Lohse MJ, Schwabe U, Cristalli G, Vittori S, Grifantini M. 2-Chloro-N6-[3H]cyclopentyladenosine ([3H]CCPA)--a high affinity agonist radioligand for A1 adenosine receptors. Naunyn-Schmiedeberg's Archives of Pharmacology. 340: 679-83. PMID 2615857 DOI: 10.1007/Bf00717744  0.624
1989 Richardt G, Waas W, Kranzhöfer R, Cheng B, Lohse MJ, Schömig A. Interaction between the release of adenosine and noradrenaline during sympathetic stimulation: a feed-back mechanism in rat heart. Journal of Molecular and Cellular Cardiology. 21: 269-77. PMID 2568492 DOI: 10.1016/0022-2828(89)90742-6  0.358
1989 Schuch U, Lohse MJ, Schachner M. Neural cell adhesion molecules influence second messenger systems Neuron. 3: 13-20. PMID 2559759 DOI: 10.1016/0896-6273(89)90111-6  0.329
1989 von der Leyen H, Schmitz W, Scholz H, Scholz J, Lohse MJ, Schwabe U. Effects of 1,3-dipropyl-8-cyclopentylxanthine (DPCPX), a highly selective adenosine receptor antagonist, on force of contraction in guinea-pig atrial and ventricular cardiac preparations. Naunyn-Schmiedeberg's Archives of Pharmacology. 340: 204-9. PMID 2554151 DOI: 10.1007/Bf00168970  0.631
1989 Lohse MJ, Lefkowitz RJ, Caron MG, Benovic JL. Inhibition of beta-adrenergic receptor kinase prevents rapid homologous desensitization of beta 2-adrenergic receptors. Proceedings of the National Academy of Sciences of the United States of America. 86: 3011-5. PMID 2541428 DOI: 10.1073/Pnas.86.9.3011  0.548
1989 Raymond JR, Fargin A, Lohse MJ, Regan JW, Senogles SE, Lefkowitz RJ, Caron MG. Identification of the ligand-binding subunit of the human 5-hydroxytryptamine1A receptor with N-(p-azido-m-[125I] iodophenethyl)spiperone, a high affinity radioiodinated photoaffinity probe. Molecular Pharmacology. 36: 15-21. PMID 2526292  0.5
1989 Lohse MJ, Maurer K, Klotz KN, Schwabe U. Synergistic effects of calcium-mobilizing agents and adenosine on histamine release from rat peritoneal mast cells. British Journal of Pharmacology. 98: 1392-8. PMID 2482106 DOI: 10.1111/J.1476-5381.1989.Tb12689.X  0.537
1989 Caron MG, Kobilka BK, Bouvier M, Hausdorff WP, Benovic JL, Lohse M, Cotecchia S, Regan JW, Fargin A, Raymond JR, Lefkowitz RJ. Catecholamine Receptors: Structure, Function, and Regulation Recent Progress in Hormone Research. 48: 195-200. DOI: 10.1007/978-3-642-75022-9_21  0.763
1988 Weber RG, Jones CR, Palacios JM, Lohse MJ. Autoradiographic visualization of A1-adenosine receptors in brain and peripheral tissues of rat and guinea pig using 125I-HPIA. Neuroscience Letters. 87: 215-20. PMID 3380344 DOI: 10.1016/0304-3940(88)90451-X  0.645
1988 Cristalli G, Franchetti P, Grifantini M, Vittori S, Klotz KN, Lohse MJ. Adenosine receptor agonists: synthesis and biological evaluation of 1-deaza analogues of adenosine derivatives. Journal of Medicinal Chemistry. 31: 1179-83. PMID 3373486 DOI: 10.1021/Jm00401A018  0.386
1988 Lohse MJ, Klotz KN, Schwabe U, Cristalli G, Vittori S, Grifantini M. 2-Chloro-N6-cyclopentyladenosine: a highly selective agonist at A1 adenosine receptors. Naunyn-Schmiedeberg's Archives of Pharmacology. 337: 687-9. PMID 3216901 DOI: 10.1007/Bf00175797  0.603
1988 Lohse MJ, Klotz KN, Diekmann E, Friedrich K, Schwabe U. 2',3'-Dideoxy-N6-cyclohexyladenosine: an adenosine derivative with antagonist properties at adenosine receptors. European Journal of Pharmacology. 156: 157-60. PMID 3208837 DOI: 10.1016/0014-2999(88)90158-6  0.631
1988 Klotz KN, Lohse MJ, Schwabe U. Chemical modification of A1 adenosine receptors in rat brain membranes. Evidence for histidine in different domains of the ligand binding site. The Journal of Biological Chemistry. 263: 17522-6. PMID 3182861  0.564
1988 Fargin A, Raymond JR, Lohse MJ, Kobilka BK, Caron MG, Lefkowitz RJ. The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor. Nature. 335: 358-60. PMID 3138543 DOI: 10.1038/335358A0  0.714
1988 Martens D, Lohse MJ, Schwabe U. [3H]-8-cyclopentyl-1,3-dipropylxanthine binding to A1 adenosine receptors of intact rat ventricular myocytes. Circulation Research. 63: 613-20. PMID 2842086 DOI: 10.1161/01.Res.63.3.613  0.64
1988 Lohse MJ, Elger B, Lindenborn-Fotinos J, Klotz KN, Schwabe U. Separation of solubilized A2 adenosine receptors of human platelets from non-receptor [3H]NECA binding sites by gel filtration. Naunyn-Schmiedeberg's Archives of Pharmacology. 337: 64-8. PMID 2835689 DOI: 10.1007/Bf00169478  0.62
1988 Lohse MJ, Klotz KN, Salzer MJ, Schwabe U. Adenosine regulates the Ca2+ sensitivity of mast cell mediator release. Proceedings of the National Academy of Sciences of the United States of America. 85: 8875-9. PMID 2461558 DOI: 10.1073/Pnas.85.23.8875  0.577
1987 Schmitz W, Scholz H, Scholz J, Steinfath M, Lohse M, Puurunen J, Schwabe U. Pertussis toxin does not inhibit the alpha 1-adrenoceptor-mediated effect on inositol phosphate production in the heart. European Journal of Pharmacology. 134: 377-8. PMID 3032660 DOI: 10.1016/0014-2999(87)90374-8  0.529
1987 Puurunen J, Lohse MJ, Schwabe U. Interactions between intracellular cyclic AMP and agonist-induced inositol phospholipid breakdown in isolated gastric mucosal cells of the rat. Naunyn-Schmiedeberg's Archives of Pharmacology. 336: 471-7. PMID 2830543 DOI: 10.1007/Bf00169301  0.571
1987 Martens D, Lohse MJ, Rauch B, Schwabe U. Pharmacological characterization of A1 adenosine receptors in isolated rat ventricular myocytes. Naunyn-Schmiedeberg's Archives of Pharmacology. 336: 342-8. PMID 2825048 DOI: 10.1007/Bf00172688  0.601
1987 Lohse MJ, Böser S, Klotz KN, Schwabe U. Affinities of barbiturates for the GABA-receptor complex and A1 adenosine receptors: a possible explanation of their excitatory effects. Naunyn-Schmiedeberg's Archives of Pharmacology. 336: 211-7. PMID 2825044 DOI: 10.1007/Bf00165807  0.618
1987 Lohse MJ, Klotz KN, Lindenborn-Fotinos J, Reddington M, Schwabe U, Olsson RA. 8-Cyclopentyl-1,3-dipropylxanthine (DPCPX)--a selective high affinity antagonist radioligand for A1 adenosine receptors. Naunyn-Schmiedeberg's Archives of Pharmacology. 336: 204-10. PMID 2825043 DOI: 10.1007/Bf00165806  0.632
1987 Lohse MJ, Maurer K, Gensheimer HP, Schwabe U. Dual actions of adenosine on rat peritoneal mast cells. Naunyn-Schmiedeberg's Archives of Pharmacology. 335: 555-60. PMID 2441269 DOI: 10.1007/Bf00169124  0.599
1986 Klotz KN, Lohse MJ. The glycoprotein nature of A1 adenosine receptors Biochemical and Biophysical Research Communications. 140: 406-413. PMID 3778456 DOI: 10.1016/0006-291X(86)91105-8  0.456
1986 Lohse MJ, Klotz KN, Schwabe U. Agonist photoaffinity labeling of A1 adenosine receptors: persistent activation reveals spare receptors. Molecular Pharmacology. 30: 403-9. PMID 3020390  0.603
1986 Klotz KN, Lohse MJ, Schwabe U. Characterization of the solubilized A1 adenosine receptor from rat brain membranes. Journal of Neurochemistry. 46: 1528-34. PMID 3007672 DOI: 10.1111/J.1471-4159.1986.Tb01772.X  0.645
1986 Lohse MJ, Klotz KN, Schwabe U. Effects of temperature and membrane phase transitions on ligand binding to alpha 2-receptors of human platelets. Molecular Pharmacology. 29: 228-34. PMID 3005830  0.553
1986 Cristalli G, Grifantini M, Vittori S, Klotz K, Lohse MJ. Synthesis of 2-Azido-(R)-N6-p-hydroxyphenylisopropyladenosine (R-AHPIA) as Potential Photoaffinity Probe for A1Adenosine Receptors Nucleosides and Nucleotides. 5: 213-222. DOI: 10.1080/07328318608068674  0.358
1985 Schwabe U, Ukena D, Lohse MJ. Xanthine derivatives as antagonists at A1 and A2 adenosine receptors. Naunyn-Schmiedeberg's Archives of Pharmacology. 330: 212-21. PMID 2997628 DOI: 10.1007/Bf00572436  0.598
1985 Lohse MJ, Klotz KN, Jakobs KH, Schwabe U. Barbiturates are selective antagonists at A1 adenosine receptors. Journal of Neurochemistry. 45: 1761-70. PMID 2997396 DOI: 10.1111/J.1471-4159.1985.Tb10532.X  0.63
1985 Lohse MJ, Ukena D, Schwabe U. Demonstration of Ri-type adenosine receptors in bovine myocardium by radioligand binding. Naunyn-Schmiedeberg's Archives of Pharmacology. 328: 310-6. PMID 2984586 DOI: 10.1007/Bf00515559  0.651
1984 Lohse MJ, Ukena D, Schwabe U. Adenosine receptors on heart muscle. Lancet (London, England). 2: 355. PMID 6146898 DOI: 10.1016/S0140-6736(84)92725-9  0.597
1984 Lohse MJ, Klotz KN, Ukena D, Schwabe U. Characterization of [3H]phenobarbital binding to rat brain membranes. Neuroscience Letters. 52: 97-101. PMID 6098882 DOI: 10.1016/0304-3940(84)90357-4  0.531
1984 Ukena D, Furler R, Lohse MJ, Engel G, Schwabe U. Labelling of Ri adenosine receptors in rat fat cell membranes with (-)-[125iodo]N6-hydroxyphenylisopropyladenosine. Naunyn-Schmiedeberg's Archives of Pharmacology. 326: 233-40. PMID 6089004 DOI: 10.1007/Bf00505324  0.597
1984 Lohse MJ, Lenschow V, Schwabe U. Interaction of barbiturates with adenosine receptors in rat brain. Naunyn-Schmiedeberg's Archives of Pharmacology. 326: 69-74. PMID 6089000 DOI: 10.1007/Bf00518781  0.644
1984 Lohse MJ, Lenschow V, Schwabe U. Two affinity states of Ri adenosine receptors in brain membranes. Analysis of guanine nucleotide and temperature effects on radioligand binding. Molecular Pharmacology. 26: 1-9. PMID 6087114  0.562
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