Lutz Hein - Publications

Affiliations: 
1996-2004 Pharmacology University of Freiburg, Germany, Freiburg im Breisgau, Baden-Württemberg, Germany 

127 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Rommel C, Hein L. Four Dimensions of the Cardiac Myocyte Epigenome: from Fetal to Adult Heart. Current Cardiology Reports. 22: 26. PMID 32193645 DOI: 10.1007/S11886-020-01280-7  0.352
2019 Yim YY, Betke KM, McDonald WH, Gilsbach R, Chen Y, Hyde K, Wang Q, Hein L, Hamm H. The in vivo specificity of synaptic Gβ and Gγ subunits to the α adrenergic receptor at CNS synapses. Scientific Reports. 9: 1718. PMID 30737458 DOI: 10.1038/S41598-018-37222-1  0.358
2018 Lother A, Deng L, Huck M, Fürst D, Kowalski J, Esser JS, Moser M, Bode C, Hein L. Endothelial cell mineralocorticoid receptors oppose VEGF-induced gene expression and angiogenesis. The Journal of Endocrinology. PMID 30400069 DOI: 10.1530/Joe-18-0494  0.334
2018 Harris NA, Isaac AT, Günther A, Merkel K, Melchior J, Xu M, Eguakun E, Perez R, Nabit BP, Flavin S, Gilsbach R, Shonesy B, Hein L, Abel T, Baumann A, et al. Dorsal BNST α-adrenergic receptors produce HCN-dependent excitatory actions that initiate anxiogenic behaviors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 30150361 DOI: 10.1523/Jneurosci.0963-18.2018  0.316
2018 Rommel C, Rösner S, Lother A, Barg M, Schwaderer M, Gilsbach R, Bömicke T, Schnick T, Mayer S, Doll S, Hesse M, Kretz O, Stiller B, Neumann FJ, Mann M, ... ... Hein L, et al. The Transcription Factor ETV1 Induces Atrial Remodeling and Arrhythmia. Circulation Research. PMID 29930145 DOI: 10.1161/Circresaha.118.313036  0.349
2018 Deutsch MA, Doppler SA, Li X, Lahm H, Santamaria G, Cuda G, Eichhorn S, Ratschiller T, Dzilic E, Dreßen M, Eckart A, Stark K, Massberg S, Bartels A, Rischpler C, ... ... Hein L, et al. Reactivation of the Nkx2.5 cardiac enhancer after myocardial infarction does not presage myogenesis. Cardiovascular Research. PMID 29579159 DOI: 10.1093/Cvr/Cvy069  0.321
2018 Gilsbach R, Schwaderer M, Preissl S, Grüning BA, Kranzhöfer D, Schneider P, Nührenberg TG, Mulero-Navarro S, Weichenhan D, Braun C, Dreßen M, Jacobs AR, Lahm H, Doenst T, Backofen R, ... ... Hein L, et al. Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo. Nature Communications. 9: 391. PMID 29374152 DOI: 10.1038/S41467-017-02762-Z  0.346
2018 Lother A, Bergemann S, Deng L, Moser M, Bode C, Hein L. Cardiac Endothelial Cell Transcriptome. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 29301788 DOI: 10.1161/Atvbaha.117.310549  0.319
2017 Koentges C, Pepin ME, Müsse C, Pfeil K, Alvarez SVV, Hoppe N, Hoffmann MM, Odening KE, Sossalla S, Zirlik A, Hein L, Bode C, Wende AR, Bugger H. Gene expression analysis to identify mechanisms underlying heart failure susceptibility in mice and humans. Basic Research in Cardiology. 113: 8. PMID 29288409 DOI: 10.1007/S00395-017-0666-6  0.401
2017 Lother A, Bergemann S, Kowalski J, Huck M, Gilsbach R, Bode C, Hein L. Inhibition of the cardiac myocyte mineralocorticoid receptor ameliorates doxorubicin-induced cardiotoxicity. Cardiovascular Research. PMID 28430882 DOI: 10.1093/Cvr/Cvx078  0.412
2016 Beetz N, Rommel C, Schnick T, Neumann E, Lother A, Monroy-Ordonez EB, Zeeb M, Preissl S, Gilsbach R, Melchior-Becker A, Rylski B, Stoll M, Schaefer L, Beyersdorf F, Stiller B, ... Hein L, et al. Ablation of biglycan attenuates cardiac hypertrophy and fibrosis after left ventricular pressure overload. Journal of Molecular and Cellular Cardiology. PMID 27789290 DOI: 10.1016/J.Yjmcc.2016.10.011  0.326
2016 Gupta SK, Foinquinos A, Thum S, Remke J, Zimmer K, Bauters C, de Groote P, Boon RA, de Windt LJ, Preissl S, Hein L, Batkai S, Pinet F, Thum T. Preclinical Development of a MicroRNA-Based Therapy for Elderly Patients With Myocardial Infarction. Journal of the American College of Cardiology. 68: 1557-71. PMID 27687198 DOI: 10.1016/J.Jacc.2016.07.739  0.32
2016 Lother A, Hein L. Pharmacology of Heart Failure: From Basic Science to Novel Therapies. Pharmacology & Therapeutics. PMID 27456554 DOI: 10.1016/J.Pharmthera.2016.07.004  0.341
2016 Zadori ZS, Toth VE, Feher A, Al-Khrasani M, Puskar Z, Kozsurek M, Timar J, Tabi T, Helyes Z, Hein L, Holzer P, Gyires K. Inhibition of alpha2A-adrenoceptors ameliorates DSS-induced acute intestinal inflammation in mice. The Journal of Pharmacology and Experimental Therapeutics. PMID 27418171 DOI: 10.1124/Jpet.116.235101  0.37
2016 Lother A, Hein L. Vascular Mineralocorticoid Receptors: Linking Risk Factors, Hypertension, and Heart Disease. Hypertension. PMID 27217405 DOI: 10.1161/Hypertensionaha.116.07418  0.361
2016 Schmid E, Neef S, Berlin C, Tomasovic A, Kahlert K, Nordbeck P, Deiss K, Denzinger S, Herrmann S, Wettwer E, Weidendorfer M, Becker D, Schäfer F, Wagner N, Ergün S, ... ... Hein L, et al. Erratum: Cardiac RKIP induces a beneficial β-adrenoceptor-dependent positive inotropy. Nature Medicine. 22: 217. PMID 26845407 DOI: 10.1038/nm0216-217c  0.437
2015 Lother A, Fürst D, Bergemann S, Gilsbach R, Grahammer F, Huber TB, Hilgendorf I, Bode C, Moser M, Hein L. Deoxycorticosterone Acetate/Salt-Induced Cardiac But Not Renal Injury Is Mediated By Endothelial Mineralocorticoid Receptors Independently From Blood Pressure. Hypertension. PMID 26553231 DOI: 10.1161/Hypertensionaha.115.06530  0.335
2015 Koentges C, Pfeil K, Meyer-Steenbuck M, Lother A, Hoffmann MM, Odening KE, Hein L, Bode C, Bugger H. Preserved recovery of cardiac function following ischemia-reperfusion in mice lacking SIRT3. Canadian Journal of Physiology and Pharmacology. 1-9. PMID 26524632 DOI: 10.1139/Cjpp-2015-0152  0.348
2015 Schmid E, Neef S, Berlin C, Tomasovic A, Kahlert K, Nordbeck P, Deiss K, Denzinger S, Herrmann S, Wettwer E, Weidendorfer M, Becker D, Schäfer F, Wagner N, Ergün S, ... ... Hein L, et al. Cardiac RKIP induces a beneficial β-adrenoceptor-dependent positive inotropy. Nature Medicine. PMID 26479924 DOI: 10.1038/Nm.3972  0.564
2015 Mayer S, Gilsbach R, Preissl S, Monroy Ordonez EB, Schnick T, Beetz N, Lother A, Rommel C, Ihle HM, Bugger H, Rühle F, Schrepper A, Schwarzer M, Heilmann C, Bönisch U, ... ... Hein L, et al. Adrenergic Repression of the Epigenetic Reader MeCP2 Facilitates Cardiac Adaptation in Chronic Heart Failure. Circulation Research. PMID 26195221 DOI: 10.1161/Circresaha.115.306721  0.347
2015 Preissl S, Schwaderer M, Raulf A, Hesse M, Grüning BA, Köbele C, Backofen R, Fleischmann BK, Hein L, Gilsbach R. Deciphering the Epigenetic Code of Cardiac Myocyte Transcription. Circulation Research. 117: 413-23. PMID 26105955 DOI: 10.1161/Circresaha.115.306337  0.309
2015 Nührenberg TG, Hammann N, Schnick T, Preißl S, Witten A, Stoll M, Gilsbach R, Neumann FJ, Hein L. Cardiac Myocyte De Novo DNA Methyltransferases 3a/3b Are Dispensable for Cardiac Function and Remodeling after Chronic Pressure Overload in Mice. Plos One. 10: e0131019. PMID 26098432 DOI: 10.1371/Journal.Pone.0131019  0.348
2015 Koentges C, König A, Pfeil K, Hölscher ME, Schnick T, Wende AR, Schrepper A, Cimolai MC, Kersting S, Hoffmann MM, Asal J, Osterholt M, Odening KE, Doenst T, Hein L, et al. Myocardial mitochondrial dysfunction in mice lacking adiponectin receptor 1. Basic Research in Cardiology. 110: 37. PMID 25982881 DOI: 10.1007/S00395-015-0495-4  0.347
2015 Koentges C, Pfeil K, Schnick T, Wiese S, Dahlbock R, Cimolai MC, Meyer-Steenbuck M, Cenkerova K, Hoffmann MM, Jaeger C, Odening KE, Kammerer B, Hein L, Bode C, Bugger H. SIRT3 deficiency impairs mitochondrial and contractile function in the heart. Basic Research in Cardiology. 110: 36. PMID 25962702 DOI: 10.1007/S00395-015-0493-6  0.369
2015 Weise M, Vettel C, Spiger K, Gilsbach R, Hein L, Lorenz K, Wieland T, Aktories K, Orth JH. A systemic Pasteurella multocida toxin aggravates cardiac hypertrophy and fibrosis in mice. Cellular Microbiology. 17: 1320-31. PMID 25759205 DOI: 10.1111/Cmi.12436  0.377
2015 Lother A, Moser M, Bode C, Feldman RD, Hein L. Mineralocorticoids in the heart and vasculature: new insights for old hormones. Annual Review of Pharmacology and Toxicology. 55: 289-312. PMID 25251996 DOI: 10.1146/Annurev-Pharmtox-010814-124302  0.389
2014 Nührenberg T, Gilsbach R, Preissl S, Schnick T, Hein L. Epigenetics in cardiac development, function, and disease. Cell and Tissue Research. 356: 585-600. PMID 24817102 DOI: 10.1007/S00441-014-1887-8  0.337
2013 Guenther F, Herr N, Mauler M, Witsch T, Roming F, Hein L, Boeynaems JM, Robaye B, Idzko M, Bode C, Von Zur Muhlen C, Duerschmied D. Contrast ultrasound for the quantification of deep vein thrombosis in living mice: effects of enoxaparin and P2Y12 receptor inhibition. Journal of Thrombosis and Haemostasis : Jth. 11: 1154-62. PMID 23551896 DOI: 10.1111/Jth.12206  0.356
2013 Zádori ZS, Fehér Á, Al-Khrasani M, Lackó E, Tóth VE, Brancati SB, Hein L, Mátyus P, Gyires K. Imidazoline versus alpha₂-adrenoceptors in the control of gastric motility in mice. European Journal of Pharmacology. 705: 61-7. PMID 23499689 DOI: 10.1016/J.Ejphar.2013.02.043  0.391
2013 Koentges C, Pfeil K, Schnick T, Hein L, Bode C, Bugger H. SIRT3 deficiency impairs contractile function in the heart European Heart Journal. 34: 779-779. DOI: 10.1093/Eurheartj/Eht308.779  0.377
2012 Biermann D, Heilmann A, Didié M, Schlossarek S, Wahab A, Grimm M, Römer M, Reichenspurner H, Sultan KR, Steenpass A, Ergün S, Donzelli S, Carrier L, Ehmke H, Zimmermann WH, ... Hein L, et al. Impact of AT2 receptor deficiency on postnatal cardiovascular development. Plos One. 7: e47916. PMID 23144713 DOI: 10.1371/Journal.Pone.0047916  0.373
2012 Riccio O, Hurni N, Murthy S, Vutskits L, Hein L, Dayer A. Alpha2-adrenergic receptor activation regulates cortical interneuron migration. The European Journal of Neuroscience. 36: 2879-87. PMID 22805283 DOI: 10.1111/J.1460-9568.2012.08231.X  0.38
2012 Gilsbach R, Hein L. Are the pharmacology and physiology of α₂ adrenoceptors determined by α₂-heteroreceptors and autoreceptors respectively? British Journal of Pharmacology. 165: 90-102. PMID 21658028 DOI: 10.1111/J.1476-5381.2011.01533.X  0.33
2011 Hein L. [Structure and evolution of adrenergic receptors]. Pharmazie in Unserer Zeit. 40: 470-3. PMID 22028130 DOI: 10.1002/Pauz.201100441  0.321
2011 Zádori ZS, Shujaa N, Brancati SB, Hein L, Gyires K. Both α2B- and α2C-adrenoceptor subtypes are involved in the mediation of centrally induced gastroprotection in mice. European Journal of Pharmacology. 669: 115-20. PMID 21816147 DOI: 10.1016/J.Ejphar.2011.07.018  0.303
2011 Brede M, Braeuninger S, Langhauser F, Hein L, Roewer N, Stoll G, Kleinschnitz C. α(2)-adrenoceptors do not mediate neuroprotection in acute ischemic stroke in mice. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 31: e1-7. PMID 21792243 DOI: 10.1038/Jcbfm.2011.110  0.305
2011 Gilsbach R, Albarrán-Juárez J, Hein L. Pre- versus postsynaptic signaling by α(2)-adrenoceptors. Current Topics in Membranes. 67: 139-60. PMID 21771489 DOI: 10.1016/B978-0-12-384921-2.00007-0  0.334
2011 Schneider J, Lother A, Hein L, Gilsbach R. Chronic cardiac pressure overload induces adrenal medulla hypertrophy and increased catecholamine synthesis. Basic Research in Cardiology. 106: 591-602. PMID 21547520 DOI: 10.1007/S00395-011-0166-Z  0.436
2011 Shujaa N, Al-Khrasani M, Zádori ZS, Rossi M, Mátyus P, Németh J, Hein L, Gyires K. α(2)-adrenoceptor agonist-induced inhibition of gastric motor activity is mediated by α(2A)-adrenoceptor subtype in the mouse. Neurochemistry International. 58: 708-13. PMID 21333706 DOI: 10.1016/J.Neuint.2011.02.011  0.307
2011 Lother A, Berger S, Gilsbach R, Rösner S, Ecke A, Barreto F, Bauersachs J, Schütz G, Hein L. Ablation of mineralocorticoid receptors in myocytes but not in fibroblasts preserves cardiac function. Hypertension. 57: 746-54. PMID 21321305 DOI: 10.1161/Hypertensionaha.110.163287  0.449
2011 Fraccarollo D, Berger S, Galuppo P, Kneitz S, Hein L, Schütz G, Frantz S, Ertl G, Bauersachs J. Deletion of cardiomyocyte mineralocorticoid receptor ameliorates adverse remodeling after myocardial infarction. Circulation. 123: 400-8. PMID 21242479 DOI: 10.1161/Circulationaha.110.983023  0.402
2011 Faerber G, Barreto-Perreia F, Schoepe M, Gilsbach R, Schrepper A, Schwarzer M, Mohr FW, Hein L, Doenst T. Induction of heart failure by minimally invasive aortic constriction in mice: reduced peroxisome proliferator-activated receptor γ coactivator levels and mitochondrial dysfunction. The Journal of Thoracic and Cardiovascular Surgery. 141: 492-500, 500.e1. PMID 20447656 DOI: 10.1016/J.Jtcvs.2010.03.029  0.375
2011 Hoch H, Stegbauer J, Potthoff SA, Koenigshausen E, Hein L, Rump LC, Vonend O. α2A-ADRENERGIC RECEPTOR DEFICIENCY AMELIORATES PROGRESSION OF CHRONIC KIDNEY DISEASE Journal of Hypertension. 29: e203. DOI: 10.1097/00004872-201106001-00545  0.313
2011 Zádori Z, Fehér Á, Shujaa N, Al-Khrasani M, Lackó E, Brancati S, Hein L, Gyires K. In vitro analysis of the role of alpha2- and imidazoline receptors in the regulation of gastric motility in mice Zeitschrift FüR Gastroenterologie. 49. DOI: 10.1055/S-0031-1278530  0.377
2010 Haubold M, Gilsbach R, Hein L. {Alpha}2B-adrenoceptor deficiency leads to postnatal respiratory failure in mice. The Journal of Biological Chemistry. 285: 34213-9. PMID 20729197 DOI: 10.1074/Jbc.M110.129205  0.354
2010 Clere N, Corre I, Faure S, Guihot AL, Vessières E, Chalopin M, Morel A, Coqueret O, Hein L, Delneste Y, Paris F, Henrion D. Deficiency or blockade of angiotensin II type 2 receptor delays tumorigenesis by inhibiting malignant cell proliferation and angiogenesis. International Journal of Cancer. Journal International Du Cancer. 127: 2279-91. PMID 20143398 DOI: 10.1002/Ijc.25234  0.301
2010 Yanpallewar SU, Fernandes K, Marathe SV, Vadodaria KC, Jhaveri D, Rommelfanger K, Ladiwala U, Jha S, Muthig V, Hein L, Bartlett P, Weinshenker D, Vaidya VA. Alpha2-adrenoceptor blockade accelerates the neurogenic, neurotrophic, and behavioral effects of chronic antidepressant treatment. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 1096-109. PMID 20089918 DOI: 10.1523/Jneurosci.2309-09.2010  0.333
2010 Gilsbach R, Schneider J, Lother A, Schickinger S, Leemhuis J, Hein L. Sympathetic alpha(2)-adrenoceptors prevent cardiac hypertrophy and fibrosis in mice at baseline but not after chronic pressure overload. Cardiovascular Research. 86: 432-42. PMID 20083574 DOI: 10.1093/Cvr/Cvq014  0.418
2010 Yalcin I, Tessier LH, Petit-Demoulière N, Waltisperger E, Hein L, Freund-Mercier MJ, Barrot M. Chronic treatment with agonists of beta(2)-adrenergic receptors in neuropathic pain. Experimental Neurology. 221: 115-21. PMID 19840789 DOI: 10.1016/J.Expneurol.2009.10.008  0.344
2010 Zádori Z, Shujaa N, Décsei O, Dabi A, Hein L, Gyires K. Analysis of α2-adrenoceptor subtypes involved in the regulation of gastroprotection and gastric motility in mice Zeitschrift FüR Gastroenterologie. 48. DOI: 10.1055/S-0030-1254837  0.312
2009 Beetz N, Harrison MD, Brede M, Zong X, Urbanski MJ, Sietmann A, Kaufling J, Lorkowski S, Barrot M, Seeliger MW, Vieira-Coelho MA, Hamet P, Gaudet D, Seda O, Tremblay J, ... ... Hein L, et al. Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice. The Journal of Clinical Investigation. 119: 3597-3612. PMID 19959875 DOI: 10.1172/Jci38433  0.518
2009 Beetz N, Hein L, Meszaros J, Gilsbach R, Barreto F, Meissner M, Hoppe UC, Schwartz A, Herzig S, Matthes J. Transgenic simulation of human heart failure-like L-type Ca2+-channels: implications for fibrosis and heart rate in mice. Cardiovascular Research. 84: 396-406. PMID 19620129 DOI: 10.1093/Cvr/Cvp251  0.383
2009 Albarrán-Juárez J, Gilsbach R, Piekorz RP, Pexa K, Beetz N, Schneider J, Nürnberg B, Birnbaumer L, Hein L. Modulation of alpha2-adrenoceptor functions by heterotrimeric Galphai protein isoforms. The Journal of Pharmacology and Experimental Therapeutics. 331: 35-44. PMID 19589951 DOI: 10.1124/Jpet.109.157230  0.407
2009 Gilsbach R, Röser C, Beetz N, Brede M, Hadamek K, Haubold M, Leemhuis J, Philipp M, Schneider J, Urbanski M, Szabo B, Weinshenker D, Hein L. Genetic dissection of alpha2-adrenoceptor functions in adrenergic versus nonadrenergic cells. Molecular Pharmacology. 75: 1160-70. PMID 19251826 DOI: 10.1124/Mol.109.054544  0.398
2009 Benndorf RA, Krebs C, Hirsch-Hoffmann B, Schwedhelm E, Cieslar G, Schmidt-Haupt R, Steinmetz OM, Meyer-Schwesinger C, Thaiss F, Haddad M, Fehr S, Heilmann A, Helmchen U, Hein L, Ehmke H, et al. Angiotensin II type 2 receptor deficiency aggravates renal injury and reduces survival in chronic kidney disease in mice. Kidney International. 75: 1039-49. PMID 19212419 DOI: 10.1038/Ki.2009.2  0.375
2009 Schmitt JP, Ahmad F, Lorenz K, Hein L, Schulz S, Asahi M, Maclennan DH, Seidman CE, Seidman JG, Lohse MJ. Alterations of phospholamban function can exhibit cardiotoxic effects independent of excessive sarcoplasmic reticulum Ca2+-ATPase inhibition. Circulation. 119: 436-44. PMID 19139388 DOI: 10.1161/Circulationaha.108.783506  0.572
2009 Yalcin I, Tessier LH, Petit-Demoulière N, Doridot S, Hein L, Freund-Mercier MJ, Barrot M. Beta2-adrenoceptors are essential for desipramine, venlafaxine or reboxetine action in neuropathic pain. Neurobiology of Disease. 33: 386-94. PMID 19084064 DOI: 10.1016/J.Nbd.2008.11.003  0.384
2008 Hein L. [Alpha 1 adrenergic antagonists]. Pharmazie in Unserer Zeit. 37: 290-5. PMID 18570283 DOI: 10.1002/Pauz.200700271  0.302
2008 Dahmani S, Paris A, Jannier V, Hein L, Rouelle D, Scholz J, Gressens P, Mantz J. Dexmedetomidine increases hippocampal phosphorylated extracellular signal-regulated protein kinase 1 and 2 content by an alpha 2-adrenoceptor-independent mechanism: evidence for the involvement of imidazoline I1 receptors. Anesthesiology. 108: 457-66. PMID 18292683 DOI: 10.1097/Aln.0B013E318164Ca81  0.351
2008 Gilsbach R, Hein L. Presynaptic metabotropic receptors for acetylcholine and adrenaline/noradrenaline. Handbook of Experimental Pharmacology. 261-88. PMID 18064417 DOI: 10.1007/978-3-540-74805-2_9  0.391
2007 Muthig V, Gilsbach R, Haubold M, Philipp M, Ivacevic T, Gessler M, Hein L. Upregulation of soluble vascular endothelial growth factor receptor 1 contributes to angiogenesis defects in the placenta of alpha 2B-adrenoceptor deficient mice. Circulation Research. 101: 682-91. PMID 17673674 DOI: 10.1161/Circresaha.107.151563  0.392
2007 Kuba K, Zhang L, Imai Y, Arab S, Chen M, Maekawa Y, Leschnik M, Leibbrandt A, Markovic M, Makovic M, Schwaighofer J, Beetz N, Musialek R, Neely GG, Komnenovic V, ... ... Hein L, et al. Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload. Circulation Research. 101: e32-42. PMID 17673668 DOI: 10.1161/Circresaha.107.158659  0.414
2007 Knaus AE, Muthig V, Schickinger S, Moura E, Beetz N, Gilsbach R, Hein L. Alpha2-adrenoceptor subtypes--unexpected functions for receptors and ligands derived from gene-targeted mouse models. Neurochemistry International. 51: 277-81. PMID 17664025 DOI: 10.1016/J.Neuint.2007.06.036  0.407
2007 Gilsbach R, Brede M, Beetz N, Moura E, Muthig V, Gerstner C, Barreto F, Neubauer S, Vieira-Coelho MA, Hein L. Heterozygous alpha 2C-adrenoceptor-deficient mice develop heart failure after transverse aortic constriction. Cardiovascular Research. 75: 728-37. PMID 17597596 DOI: 10.1016/J.Cardiores.2007.05.017  0.394
2007 Hullin R, Matthes J, von Vietinghoff S, Bodi I, Rubio M, D'Souza K, Friedrich Khan I, Rottländer D, Hoppe UC, Mohacsi P, Schmitteckert E, Gilsbach R, Bünemann M, Hein L, Schwartz A, et al. Increased expression of the auxiliary beta(2)-subunit of ventricular L-type Ca(2)+ channels leads to single-channel activity characteristic of heart failure. Plos One. 2: e292. PMID 17356701 DOI: 10.1371/Journal.Pone.0000292  0.374
2007 Munk VC, Sanchez de Miguel L, Petrimpol M, Butz N, Banfi A, Eriksson U, Hein L, Humar R, Battegay EJ. Angiotensin II induces angiogenesis in the hypoxic adult mouse heart in vitro through an AT2-B2 receptor pathway. Hypertension. 49: 1178-85. PMID 17339539 DOI: 10.1161/Hypertensionaha.106.080242  0.395
2007 Knaus A, Zong X, Beetz N, Jahns R, Lohse MJ, Biel M, Hein L. Direct inhibition of cardiac hyperpolarization-activated cyclic nucleotide-gated pacemaker channels by clonidine. Circulation. 115: 872-80. PMID 17261653 DOI: 10.1161/Circulationaha.106.667675  0.578
2007 Vonend O, Habbel S, Stegbauer J, Roth J, Hein L, Rump LC. α 2A-adrenoceptors regulate sympathetic transmitter release in mice kidneys British Journal of Pharmacology. 150: 121-127. PMID 17115069 DOI: 10.1038/Sj.Bjp.0706961  0.327
2007 BOIVIN V, PALM D, FROST R, HEIN L, ANGERMANN C, ERTL G, LOHSE M, JAHNS R. 115 Combination-therapy with neutralizing cyclopeptides and beta-blockers decreases molecular markers of sympathetic activation and reverses cardiomyopathy in beta1-receptor antibody-induced heart failure European Journal of Heart Failure Supplements. 6: 28-28. DOI: 10.1016/S1567-4215(07)60075-7  0.544
2006 Moura E, Afonso J, Hein L, Vieira-Coelho MA. α 2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice British Journal of Pharmacology. 149: 1049-1058. PMID 17075569 DOI: 10.1038/Sj.Bjp.0706950  0.368
2006 Störk S, Boivin V, Horf R, Hein L, Lohse MJ, Angermann CE, Jahns R. Stimulating autoantibodies directed against the cardiac beta1-adrenergic receptor predict increased mortality in idiopathic cardiomyopathy. American Heart Journal. 152: 697-704. PMID 16996841 DOI: 10.1016/J.Ahj.2006.05.004  0.459
2006 Hein L. Adrenoceptors and signal transduction in neurons. Cell and Tissue Research. 326: 541-51. PMID 16896948 DOI: 10.1007/S00441-006-0285-2  0.381
2006 Paris A, Mantz J, Tonner PH, Hein L, Brede M, Gressens P. The effects of dexmedetomidine on perinatal excitotoxic brain injury are mediated by the alpha2A-adrenoceptor subtype. Anesthesia and Analgesia. 102: 456-61. PMID 16428542 DOI: 10.1213/01.Ane.0000194301.79118.E9  0.335
2006 Regitz-Zagrosek V, Hocher B, Bettmann M, Brede M, Hadamek K, Gerstner C, Lehmkuhl HB, Hetzer R, Hein L. Alpha2C-adrenoceptor polymorphism is associated with improved event-free survival in patients with dilated cardiomyopathy. European Heart Journal. 27: 454-9. PMID 16299019 DOI: 10.1093/Eurheartj/Ehi659  0.327
2005 Hein L. Angiotensin II and cell-matrix adhesion: PKCepsilon is essential. Cardiovascular Research. 67: 6-8. PMID 15922318 DOI: 10.1016/J.Cardiores.2005.05.008  0.356
2005 Boivin V, Hein L, Angermann CE, Palm D, ller JM, Ertl G, Lohse MJ, Jahns R. 104 A novel receptor‐homologous cyclic peptide prevents beta1‐adrenoceptor antibody‐induced progressive cardiomyopathy European Journal of Heart Failure Supplements. 4: 24-24. DOI: 10.1016/S1567-4215(05)80062-1  0.435
2004 Fagerholm V, Philipp M, Hein L, Scheinin M. [Ethyl-3H]RS-79948-197 alpha2-adrenoceptor autoradiography validation in alpha2-adrenoceptor knockout mice. European Journal of Pharmacology. 497: 301-9. PMID 15336948 DOI: 10.1016/J.Ejphar.2004.06.065  0.315
2004 Nikolaev VO, Bünemann M, Hein L, Hannawacker A, Lohse MJ. Novel single chain cAMP sensors for receptor-induced signal propagation. The Journal of Biological Chemistry. 279: 37215-8. PMID 15231839 DOI: 10.1074/Jbc.C400302200  0.437
2004 Brede M, Philipp M, Knaus A, Muthig V, Hein L. alpha2-adrenergic receptor subtypes - novel functions uncovered in gene-targeted mouse models. Biology of the Cell / Under the Auspices of the European Cell Biology Organization. 96: 343-8. PMID 15207902 DOI: 10.1016/J.Biolcel.2004.03.006  0.404
2004 Jahns R, Boivin V, Hein L, Triebel S, Angermann CE, Ertl G, Lohse MJ. Direct evidence for a beta 1-adrenergic receptor-directed autoimmune attack as a cause of idiopathic dilated cardiomyopathy. The Journal of Clinical Investigation. 113: 1419-29. PMID 15146239 DOI: 10.1172/Jci20149  0.549
2004 Kirchhefer U, Jones LR, Begrow F, Boknik P, Hein L, Lohse MJ, Riemann B, Schmitz W, Stypmann J, Neumann J. Transgenic triadin 1 overexpression alters SR Ca2+ handling and leads to a blunted contractile response to beta-adrenergic agonists. Cardiovascular Research. 62: 122-34. PMID 15023559 DOI: 10.1016/J.Cardiores.2004.01.005  0.541
2004 Engelhardt S, Hein L, Dyachenkow V, Kranias EG, Isenberg G, Lohse MJ. Altered calcium handling is critically involved in the cardiotoxic effects of chronic beta-adrenergic stimulation. Circulation. 109: 1154-60. PMID 14967726 DOI: 10.1161/01.Cir.0000117254.68497.39  0.592
2004 Niederhoffer N, Hein L, Starke K. Modulation of the baroreceptor reflex by alpha 2A-adrenoceptors: a study in alpha 2A knockout mice. British Journal of Pharmacology. 141: 851-9. PMID 14769782 DOI: 10.1038/Sj.Bjp.0705636  0.371
2004 Vonend O, Stegbauer J, Habbel S, Hein L, Rump LC. MODULATION OF SYMPATHETIC NEUROTRANSMITTER-RELEASE IN KIDNEYS OF WILDTYPE AND ALPHA2A-ADRENOCEPTOR KNOCKOUT MICE Journal of Hypertension. 22: S78-S79. DOI: 10.1097/00004872-200406002-00268  0.322
2003 Gaussin V, Tomlinson JE, Depre C, Engelhardt S, Antos CL, Takagi G, Hein L, Topper JN, Liggett SB, Olson EN, Lohse MJ, Vatner SF, Vatner DE. Common genomic response in different mouse models of beta-adrenergic-induced cardiomyopathy. Circulation. 108: 2926-33. PMID 14623810 DOI: 10.1161/01.Cir.0000101922.18151.7B  0.544
2003 Trendelenburg AU, Philipp M, Meyer A, Klebroff W, Hein L, Starke K. All three alpha2-adrenoceptor types serve as autoreceptors in postganglionic sympathetic neurons. Naunyn-Schmiedeberg's Archives of Pharmacology. 368: 504-12. PMID 14610637 DOI: 10.1007/S00210-003-0829-X  0.338
2003 Brede M, Roell W, Ritter O, Wiesmann F, Jahns R, Haase A, Fleischmann BK, Hein L. Cardiac hypertrophy is associated with decreased eNOS expression in angiotensin AT2 receptor-deficient mice. Hypertension. 42: 1177-82. PMID 14581297 DOI: 10.1161/01.Hyp.0000100445.80029.8E  0.451
2003 Hein L, Schmitt JP. alpha(1)-adrenoceptors in the heart - friend or foe? Journal of Molecular and Cellular Cardiology. 35: 1183-5. PMID 14519427 DOI: 10.1016/S0022-2828(03)00241-4  0.348
2003 Peterhoff M, Sieg A, Brede M, Chao CM, Hein L, Ullrich S. Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice. European Journal of Endocrinology / European Federation of Endocrine Societies. 149: 343-50. PMID 14514350 DOI: 10.1530/Eje.0.1490343  0.332
2003 Paris A, Philipp M, Tonner PH, Steinfath M, Lohse M, Scholz J, Hein L. Activation of alpha 2B-adrenoceptors mediates the cardiovascular effects of etomidate. Anesthesiology. 99: 889-95. PMID 14508322 DOI: 10.1097/00000542-200310000-00022  0.527
2003 Eigenthaler M, Engelhardt S, Schinke B, Kobsar A, Schmitteckert E, Gambaryan S, Engelhardt CM, Krenn V, Eliava M, Jarchau T, Lohse MJ, Walter U, Hein L. Disruption of cardiac Ena-VASP protein localization in intercalated disks causes dilated cardiomyopathy. American Journal of Physiology. Heart and Circulatory Physiology. 285: H2471-81. PMID 12933343 DOI: 10.1152/Ajpheart.00362.2003  0.567
2003 Brede M, Nagy G, Philipp M, Sorensen JB, Lohse MJ, Hein L. Differential control of adrenal and sympathetic catecholamine release by alpha 2-adrenoceptor subtypes. Molecular Endocrinology (Baltimore, Md.). 17: 1640-6. PMID 12764077 DOI: 10.1210/Me.2003-0035  0.541
2003 Spindler M, Engelhardt S, Niebler R, Wagner H, Hein L, Lohse MJ, Neubauer S. Alterations in the myocardial creatine kinase system precede the development of contractile dysfunction in beta(1)-adrenergic receptor transgenic mice. Journal of Molecular and Cellular Cardiology. 35: 389-97. PMID 12689818 DOI: 10.1016/S0022-2828(03)00015-4  0.601
2003 Ritter O, Schuh K, Brede M, Röthlein N, Burkard N, Hein L, Neyses L. AT2 receptor activation regulates myocardial eNOS expression via the calcineurin-NF-AT pathway. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 283-5. PMID 12490546 DOI: 10.1096/Fj.02-0321Fje  0.373
2003 ENGELHARDT S, HEIN L, KRANIAS E, LOHSE M. 682 Phospholamban is critically involved in beta-adrenergic receptor induced cardiac hypertrophy and failure European Journal of Heart Failure Supplements. 2: 140-141. DOI: 10.1016/S1567-4215(03)90427-9  0.533
2002 Brede M, Wiesmann F, Jahns R, Hadamek K, Arnolt C, Neubauer S, Lohse MJ, Hein L. Feedback inhibition of catecholamine release by two different alpha2-adrenoceptor subtypes prevents progression of heart failure. Circulation. 106: 2491-6. PMID 12417548 DOI: 10.1161/01.Cir.0000036600.39600.66  0.536
2002 Philipp M, Brede M, Hein L. Physiological significance of alpha(2)-adrenergic receptor subtype diversity: one receptor is not enough. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 283: R287-95. PMID 12121839 DOI: 10.1152/Ajpregu.00123.2002  0.381
2002 Philipp M, Brede ME, Hadamek K, Gessler M, Lohse MJ, Hein L. Placental alpha(2)-adrenoceptors control vascular development at the interface between mother and embryo. Nature Genetics. 31: 311-5. PMID 12068299 DOI: 10.1038/Ng919  0.451
2002 Engelhardt S, Hein L, Keller U, Klämbt K, Lohse MJ. Inhibition of Na(+)-H(+) exchange prevents hypertrophy, fibrosis, and heart failure in beta(1)-adrenergic receptor transgenic mice. Circulation Research. 90: 814-9. PMID 11964375 DOI: 10.1161/01.Res.0000014966.97486.C0  0.616
2002 Bücheler MM, Hadamek K, Hein L. Two alpha(2)-adrenergic receptor subtypes, alpha(2A) and alpha(2C), inhibit transmitter release in the brain of gene-targeted mice. Neuroscience. 109: 819-26. PMID 11927164 DOI: 10.1016/S0306-4522(01)00531-0  0.378
2002 Scheibner J, Trendelenburg AU, Hein L, Starke K, Blandizzi C. Alpha 2-adrenoceptors in the enteric nervous system: a study in alpha 2A-adrenoceptor-deficient mice. British Journal of Pharmacology. 135: 697-704. PMID 11834617 DOI: 10.1038/Sj.Bjp.0704512  0.303
2002 Wiesmann F, Neubauer S, Haase A, Hein L. Can we use vertical bore magnetic resonance scanners for murine cardiovascular phenotype characterization? Influence of upright body position on left ventricular hemodynamics in mice. Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society For Cardiovascular Magnetic Resonance. 3: 311-5. PMID 11777222 DOI: 10.1081/Jcmr-100108584  0.333
2002 Scheibner J, Trendelenburg AU, Hein L, Starke K. Stimulation frequency-noradrenaline release relationships examined in alpha2A-, alpha2B- and alpha2C-adrenoceptor-deficient mice. Naunyn-Schmiedeberg's Archives of Pharmacology. 364: 321-8. PMID 11683519 DOI: 10.1007/S002100100432  0.316
2002 Trendelenburg AU, Klebroff W, Hein L, Starke K. A study of presynaptic alpha2-autoreceptors in alpha2A/D-, alpha2B- and alpha2C-adrenoceptor-deficient mice. Naunyn-Schmiedeberg's Archives of Pharmacology. 364: 117-30. PMID 11534851 DOI: 10.1007/S002100100423  0.381
2001 Brede M, Hadamek K, Meinel L, Wiesmann F, Peters J, Engelhardt S, Simm A, Haase A, Lohse MJ, Hein L. Vascular hypertrophy and increased P70S6 kinase in mice lacking the angiotensin II AT(2) receptor. Circulation. 104: 2602-7. PMID 11714657 DOI: 10.1161/Hc4601.099401  0.583
2001 Schelb V, Göbel I, Khairallah L, Zhou H, Cox SL, Trendelenburg AU, Hein L, Starke K. Postnatal development of presynaptic receptors that modulate noradrenaline release in mice Naunyn-Schmiedeberg's Archives of Pharmacology. 364: 359-371. PMID 11683524 DOI: 10.1007/S002100100455  0.357
2001 Chruscinski A, Brede ME, Meinel L, Lohse MJ, Kobilka BK, Hein L. Differential distribution of beta-adrenergic receptor subtypes in blood vessels of knockout mice lacking beta(1)- or beta(2)-adrenergic receptors. Molecular Pharmacology. 60: 955-62. PMID 11641423 DOI: 10.1124/Mol.60.5.955  0.553
2001 Engelhardt S, Boknik P, Keller U, Neumann J, Lohse MJ, Hein L. Early impairment of calcium handling and altered expression of junctin in hearts of mice overexpressing the beta1-adrenergic receptor. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 15: 2718-20. PMID 11606476 DOI: 10.1096/Fj.01-0107Fje  0.616
2001 Bünemann M, Bücheler MM, Philipp M, Lohse MJ, Hein L. Activation and deactivation kinetics of alpha 2A- and alpha 2C-adrenergic receptor-activated G protein-activated inwardly rectifying K+ channel currents. The Journal of Biological Chemistry. 276: 47512-7. PMID 11591725 DOI: 10.1074/Jbc.M108652200  0.543
2001 Wiesmann F, Ruff J, Engelhardt S, Hein L, Dienesch C, Leupold A, Illinger R, Frydrychowicz A, Hiller KH, Rommel E, Haase A, Lohse MJ, Neubauer S. Dobutamine-stress magnetic resonance microimaging in mice : acute changes of cardiac geometry and function in normal and failing murine hearts. Circulation Research. 88: 563-9. PMID 11282889 DOI: 10.1161/01.Res.88.6.563  0.576
2001 Kaumann AJ, Engelhardt S, Hein L, Molenaar P, Lohse M. Abolition of (-)-CGP 12177-evoked cardiostimulation in double β1/β2-adrenoceptor knockout mice. Obligatory role of β1-adrenoceptors for putative β4-adrenoceptor pharmacology Naunyn-Schmiedeberg's Archives of Pharmacology. 363: 87-93. PMID 11191841 DOI: 10.1007/S002100000336  0.529
2001 Scheibner J, Trendelenburg AU, Hein L, Starke K. Alpha2-adrenoceptors modulating neuronal serotonin release: a study in alpha2-adrenoceptor subtype-deficient mice. British Journal of Pharmacology. 132: 925-33. PMID 11181434 DOI: 10.1038/Sj.Bjp.0703882  0.364
2001 Brede M, Hein L. Transgenic mouse models of angiotensin receptor subtype function in the cardiovascular system. Regulatory Peptides. 96: 125-132. PMID 11111018 DOI: 10.1016/S0167-0115(00)00168-3  0.383
2001 Blandizzi C, Scheibner J, Hein L, Trendelenburg AU, del Tacca M. Altered pattern of intestinal motility in α2A/0-adrenoceptor-deficient mice Gastroenterology. 120: A179-A180. DOI: 10.1016/S0016-5085(08)80888-8  0.312
1999 Hein L, Altman JD, Kobilka BK. Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission. Nature. 402: 181-4. PMID 10647009 DOI: 10.1038/46040  0.325
1999 Altman JD, Trendelenburg AU, MacMillan L, Bernstein D, Limbird L, Starke K, Kobilka BK, Hein L. Abnormal regulation of the sympathetic nervous system in alpha2A-adrenergic receptor knockout mice. Molecular Pharmacology. 56: 154-61. PMID 10385696 DOI: 10.1124/Mol.56.1.154  0.441
1999 Engelhardt S, Hein L, Wiesmann F, Lohse MJ. Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 96: 7059-64. PMID 10359838 DOI: 10.1073/Pnas.96.12.7059  0.613
1998 MacMillan LB, Lakhlani PP, Hein L, Piascik M, Guo TZ, Lovinger D, Maze M, Limbird LE. In vivo mutation of the alpha 2A-adrenergic receptor by homologous recombination reveals the role of this receptor subtype in multiple physiological processes. Advances in Pharmacology (San Diego, Calif.). 42: 493-6. PMID 9327947 DOI: 10.1016/S1054-3589(08)60796-6  0.342
1997 Hein L, Kobilka BK. Adrenergic Receptors From Molecular Structure to in vivo function. Trends in Cardiovascular Medicine. 7: 137-45. PMID 21235877 DOI: 10.1016/S1050-1738(97)00034-0  0.359
1997 Gabilondo AM, Hegler J, Krasel C, Boivin-Jahns V, Hein L, Lohse MJ. A dileucine motif in the C terminus of the beta2-adrenergic receptor is involved in receptor internalization. Proceedings of the National Academy of Sciences of the United States of America. 94: 12285-90. PMID 9356441 DOI: 10.1073/Pnas.94.23.12285  0.55
1997 Hein L, Stevens ME, Barsh GS, Pratt RE, Kobilka BK, Dzau VJ. Overexpression of angiotensin AT1 receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block. Proceedings of the National Academy of Sciences of the United States of America. 94: 6391-6. PMID 9177228 DOI: 10.1073/Pnas.94.12.6391  0.42
1996 Link RE, Desai K, Hein L, Stevens ME, Chruscinski A, Bernstein D, Barsh GS, Kobilka BK. Cardiovascular regulation in mice lacking alpha2-adrenergic receptor subtypes b and c. Science (New York, N.Y.). 273: 803-5. PMID 8670422 DOI: 10.1126/Science.273.5276.803  0.419
1996 MacMillan LB, Hein L, Smith MS, Piascik MT, Limbird LE. Central hypotensive effects of the alpha2a-adrenergic receptor subtype. Science (New York, N.Y.). 273: 801-3. PMID 8670421 DOI: 10.1126/Science.273.5276.801  0.381
1995 Hein L, Dzau VJ, Barsh GS. Linkage mapping of the angiotensin AT2 receptor gene (Agtr2) to the mouse X chromosome. Genomics. 30: 369-71. PMID 8586443 DOI: 10.1006/Geno.1995.0033  0.323
1995 Hein L, Kobilka BK. Adrenergic receptor signal transduction and regulation. Neuropharmacology. 34: 357-66. PMID 7566466 DOI: 10.1016/0028-3908(95)00018-2  0.324
1995 Hein L, Barsh GS, Pratt RE, Dzau VJ, Kobilka BK. Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice. Nature. 377: 744-7. PMID 7477266 DOI: 10.1038/377744A0  0.389
1992 Sasamura H, Hein L, Krieger JE, Pratt RE, Kobilka BK, Dzau VJ. Cloning, characterization, and expression of two angiotensin receptor (AT-1) isoforms from the mouse genome. Biochemical and Biophysical Research Communications. 185: 253-9. PMID 1599461 DOI: 10.1016/S0006-291X(05)80983-0  0.35
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