Jonathan A. Epstein - Publications

Affiliations: 
2004 University of Pennsylvania, Philadelphia, PA, United States 

129 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Ramjee V, Li D, Manderfield LJ, Liu F, Engleka KA, Aghajanian H, Rodell CB, Lu W, Ho V, Wang T, Li L, Singh A, Cibi DM, Burdick JA, Singh MK, ... ... Epstein JA, et al. Epicardial YAP/TAZ orchestrate an immunosuppressive response following myocardial infarction. The Journal of Clinical Investigation. PMID 28165342 DOI: 10.1172/JCI88759  0.48
2016 Loh KM, Chen A, Koh PW, Deng TZ, Sinha R, Tsai JM, Barkal AA, Shen KY, Jain R, Morganti RM, Shyh-Chang N, Fernhoff NB, George BM, Wernig G, Salomon RE, ... ... Epstein JA, et al. Mapping the Pairwise Choices Leading from Pluripotency to Human Bone, Heart, and Other Mesoderm Cell Types. Cell. 166: 451-467. PMID 27419872 DOI: 10.1016/j.cell.2016.06.011  1
2016 Aghajanian H, Cho YK, Manderfield LJ, Herling MR, Gupta M, Ho VC, Li L, Degenhardt K, Aharonov A, Tzahor E, Epstein JA. Coronary vasculature patterning requires a novel endothelial ErbB2 holoreceptor. Nature Communications. 7: 12038. PMID 27356767 DOI: 10.1038/ncomms12038  1
2016 Singh A, Ramesh S, Cibi DM, Yun LS, Li J, Li L, Manderfield LJ, Olson EN, Epstein JA, Singh MK. Hippo Signaling Mediators Yap and Taz Are Required in the Epicardium for Coronary Vasculature Development. Cell Reports. PMID 27160901 DOI: 10.1016/j.celrep.2016.04.027  1
2016 He S, Mansour MR, Zimmerman MW, Ki DH, Layden HM, Akahane K, Gjini E, de Groh ED, Perez-Atayde AR, Zhu S, Epstein JA, Look AT. Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain. Elife. 5. PMID 27130733 DOI: 10.7554/eLife.14713  0.32
2015 Manderfield LJ, Engleka KA, Aghajanian H, Gupta M, Yang S, Li L, Baggs JE, Hogenesch JB, Olson EN, Epstein JA. Pax3 and Hippo Signaling Coordinate Melanocyte Gene Expression in Neural Crest. Cell Reports. 10: 841. PMID 30849859 DOI: 10.1016/j.celrep.2015.01.041  0.48
2015 Yzaguirre AD, Padmanabhan A, de Groh ED, Engleka KA, Li J, Speck NA, Epstein JA. Loss of neurofibromin Ras-GAP activity enhances the formation of cardiac blood islands in murine embryos. Elife. 4. PMID 26460546 DOI: 10.7554/eLife.07780  1
2015 Li D, Takeda N, Jain R, Manderfield LJ, Liu F, Li L, Anderson SA, Epstein JA. Hopx distinguishes hippocampal from lateral ventricle neural stem cells. Stem Cell Research. 15: 522-529. PMID 26451648 DOI: 10.1016/j.scr.2015.09.015  1
2015 Manderfield LJ, Aghajanian H, Engleka KA, Lim LY, Lui F, Jain R, Li L, Olson EN, Epstein JA. Hippo signaling is required for Notch-dependent smooth muscle differentiation of neural crest. Development (Cambridge, England). PMID 26253400 DOI: 10.1242/dev.125807  1
2015 Jones A, Opejin A, Henderson JG, Gross C, Jain R, Epstein JA, Flavell RA, Hawiger D. Peripherally Induced Tolerance Depends on Peripheral Regulatory T Cells That Require Hopx To Inhibit Intrinsic IL-2 Expression. Journal of Immunology (Baltimore, Md. : 1950). PMID 26170384 DOI: 10.4049/jimmunol.1500174  1
2015 Jain R, Li D, Gupta M, Manderfield LJ, Ifkovits JL, Wang Q, Liu F, Liu Y, Poleshko A, Padmanabhan A, Raum JC, Li L, Morrisey EE, Lu MM, Won KJ, ... Epstein JA, et al. HEART DEVELOPMENT. Integration of Bmp and Wnt signaling by Hopx specifies commitment of cardiomyoblasts. Science (New York, N.Y.). 348: aaa6071. PMID 26113728 DOI: 10.1126/science.aaa6071  1
2015 Tomas-Roca L, Tsaalbi-Shtylik A, Jansen JG, Singh MK, Epstein JA, Altunoglu U, Verzijl H, Soria L, van Beusekom E, Roscioli T, Iqbal Z, Gilissen C, Hoischen A, de Brouwer AP, Erasmus C, et al. De novo mutations in PLXND1 and REV3L cause Möbius syndrome. Nature Communications. 6: 7199. PMID 26068067 DOI: 10.1038/ncomms8199  1
2015 Zhou X, Crow AL, Hartiala J, Spindler TJ, Ghazalpour A, Barsky LW, Bennett BB, Parks BW, Eskin E, Jain R, Epstein JA, Lusis AJ, Adams GB, Allayee H. The Genetic Landscape of Hematopoietic Stem Cell Frequency in Mice. Stem Cell Reports. PMID 26050929 DOI: 10.1016/j.stemcr.2015.05.008  1
2015 Han SS, Zhang R, Jain R, Shi H, Zhang L, Zhou G, Sangwung P, Tugal D, Atkins GB, Prosdocimo DA, Lu Y, Han X, Tso P, Liao X, Epstein JA, et al. Circadian control of bile acid synthesis by a KLF15-Fgf15 axis. Nature Communications. 6: 7231. PMID 26040986 DOI: 10.1038/ncomms8231  1
2015 Jain R, Barkauskas CE, Takeda N, Bowie EJ, Aghajanian H, Wang Q, Padmanabhan A, Manderfield LJ, Gupta M, Li D, Li L, Trivedi CM, Hogan BL, Epstein JA. Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung. Nature Communications. 6: 6727. PMID 25865356 DOI: 10.1038/ncomms7727  1
2015 Minchin JE, Dahlman I, Harvey CJ, Mejhert N, Singh MK, Epstein JA, Arner P, Torres-Vázquez J, Rawls JF. Plexin D1 determines body fat distribution by regulating the type V collagen microenvironment in visceral adipose tissue. Proceedings of the National Academy of Sciences of the United States of America. 112: 4363-8. PMID 25831505 DOI: 10.1073/pnas.1416412112  1
2015 Roger VL, Boerwinkle E, Crapo JD, Douglas PS, Epstein JA, Granger CB, Greenland P, Kohane I, Psaty BM. Strategic transformation of population studies: recommendations of the working group on epidemiology and population sciences from the National Heart, Lung, and Blood Advisory Council and Board of External Experts. American Journal of Epidemiology. 181: 363-8. PMID 25743324 DOI: 10.1093/aje/kwv011  1
2015 Roger VL, Boerwinkle E, Crapo JD, Douglas PS, Epstein JA, Granger CB, Greenland P, Kohane I, Psaty BM. Roger et al. respond to "future of population studies". American Journal of Epidemiology. 181: 372-3. PMID 25743323 DOI: 10.1093/aje/kwv009  1
2015 Epstein JA, Aghajanian H, Singh MK. Semaphorin signaling in cardiovascular development. Cell Metabolism. 21: 163-73. PMID 25651171 DOI: 10.1016/j.cmet.2014.12.015  1
2015 Epstein JA, Ingram DA, Hirbe AC, Gutmann DH. A multidisciplinary approach in neurofibromatosis 1-Authors' reply The Lancet Neurology. 14: 30-31. PMID 25496893 DOI: 10.1016/S1474-4422(14)70298-4  1
2014 Manderfield LJ, Engleka KA, Aghajanian H, Gupta M, Yang S, Li L, Baggs JE, Hogenesch JB, Olson EN, Epstein JA. Pax3 and hippo signaling coordinate melanocyte gene expression in neural crest. Cell Reports. 9: 1885-95. PMID 25466249 DOI: 10.1016/j.celrep.2014.10.061  1
2014 Li N, Yousefi M, Nakauka-Ddamba A, Jain R, Tobias J, Epstein JA, Jensen ST, Lengner CJ. Single-cell analysis of proxy reporter allele-marked epithelial cells establishes intestinal stem cell hierarchy. Stem Cell Reports. 3: 876-91. PMID 25418730 DOI: 10.1016/j.stemcr.2014.09.011  1
2014 Chen HI, Sharma B, Akerberg BN, Numi HJ, Kivelä R, Saharinen P, Aghajanian H, McKay AS, Bogard PE, Chang AH, Jacobs AH, Epstein JA, Stankunas K, Alitalo K, Red-Horse K. The sinus venosus contributes to coronary vasculature through VEGFC-stimulated angiogenesis. Development (Cambridge, England). 141: 4500-12. PMID 25377552 DOI: 10.1242/dev.113639  1
2014 Wolman MA, de Groh ED, McBride SM, Jongens TA, Granato M, Epstein JA. Modulation of cAMP and ras signaling pathways improves distinct behavioral deficits in a zebrafish model of neurofibromatosis type 1. Cell Reports. 8: 1265-70. PMID 25176649 DOI: 10.1016/j.celrep.2014.07.054  1
2014 Hogan BL, Barkauskas CE, Chapman HA, Epstein JA, Jain R, Hsia CC, Niklason L, Calle E, Le A, Randell SH, Rock J, Snitow M, Krummel M, Stripp BR, Vu T, et al. Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function. Cell Stem Cell. 15: 123-38. PMID 25105578 DOI: 10.1016/j.stem.2014.07.012  1
2014 Aghajanian H, Choi C, Ho VC, Gupta M, Singh MK, Epstein JA. Semaphorin 3d and semaphorin 3e direct endothelial motility through distinct molecular signaling pathways. The Journal of Biological Chemistry. 289: 17971-9. PMID 24825896 DOI: 10.1074/jbc.M113.544833  1
2014 Gerhardt DM, Pajcini KV, D'altri T, Tu L, Jain R, Xu L, Chen MJ, Rentschler S, Shestova O, Wertheim GB, Tobias JW, Kluk M, Wood AW, Aster JC, Gimotty PA, ... Epstein JA, et al. The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells. Genes & Development. 28: 576-93. PMID 24637115 DOI: 10.1101/gad.227496.113  1
2014 Ifkovits JL, Addis RC, Epstein JA, Gearhart JD. Inhibition of TGFβ signaling increases direct conversion of fibroblasts to induced cardiomyocytes. Plos One. 9: e89678. PMID 24586958 DOI: 10.1371/journal.pone.0089678  1
2014 Worzfeld T, Swiercz JM, Sentürk A, Genz B, Korostylev A, Deng S, Xia J, Hoshino M, Epstein JA, Chan AM, Vollmar B, Acker-Palmer A, Kuner R, Offermanns S. Genetic dissection of plexin signaling in vivo. Proceedings of the National Academy of Sciences of the United States of America. 111: 2194-9. PMID 24469813 DOI: 10.1073/pnas.1308418111  1
2014 Zhao T, Gan Q, Stokes A, Lassiter RN, Wang Y, Chan J, Han JX, Pleasure DE, Epstein JA, Zhou CJ. β-catenin regulates Pax3 and Cdx2 for caudal neural tube closure and elongation. Development (Cambridge, England). 141: 148-57. PMID 24284205 DOI: 10.1242/dev.101550  1
2013 Choi YI, Duke-Cohan JS, Tan J, Gui J, Singh MK, Epstein JA, Reinherz EL. Plxnd1 expression in thymocytes regulates their intrathymic migration while that in thymic endothelium impacts medullary topology. Frontiers in Immunology. 4: 392. PMID 24312099 DOI: 10.3389/fimmu.2013.00392  1
2013 Addis RC, Epstein JA. Induced regeneration--the progress and promise of direct reprogramming for heart repair. Nature Medicine. 19: 829-36. PMID 23836233 DOI: 10.1038/nm.3225  1
2013 Takeda N, Jain R, Li D, Li L, Lu MM, Epstein JA. Lgr5 Identifies Progenitor Cells Capable of Taste Bud Regeneration after Injury. Plos One. 8: e66314. PMID 23824276 DOI: 10.1371/journal.pone.0066314  1
2013 Degenhardt K, Singh MK, Aghajanian H, Massera D, Wang Q, Li J, Li L, Choi C, Yzaguirre AD, Francey LJ, Gallant E, Krantz ID, Gruber PJ, Epstein JA. Semaphorin 3d signaling defects are associated with anomalous pulmonary venous connections. Nature Medicine. 19: 760-5. PMID 23685842 DOI: 10.1038/nm.3185  1
2013 Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, et al. Molecular determinants of lung development. Annals of the American Thoracic Society. 10: S12-6. PMID 23607856 DOI: 10.1513/AnnalsATS.201207-036OT  1
2013 Addis RC, Ifkovits JL, Pinto F, Kellam LD, Esteso P, Rentschler S, Christoforou N, Epstein JA, Gearhart JD. Optimization of direct fibroblast reprogramming to cardiomyocytes using calcium activity as a functional measure of success. Journal of Molecular and Cellular Cardiology. 60: 97-106. PMID 23591016 DOI: 10.1016/j.yjmcc.2013.04.004  1
2013 Singh N, Gupta M, Trivedi CM, Singh MK, Li L, Epstein JA. Murine craniofacial development requires Hdac3-mediated repression of Msx gene expression. Developmental Biology. 377: 333-44. PMID 23506836 DOI: 10.1016/j.ydbio.2013.03.008  1
2013 Parmacek MS, Epstein JA. An epigenetic roadmap for cardiomyocyte differentiation. Circulation Research. 112: 881-3. PMID 23493303 DOI: 10.1161/CIRCRESAHA.113.301134  1
2013 Takeda N, Jain R, Leboeuf MR, Padmanabhan A, Wang Q, Li L, Lu MM, Millar SE, Epstein JA. Hopx expression defines a subset of multipotent hair follicle stem cells and a progenitor population primed to give rise to K6+ niche cells. Development (Cambridge, England). 140: 1655-64. PMID 23487314 DOI: 10.1242/dev.093005  1
2013 Meadows SM, Ratliff LA, Singh MK, Epstein JA, Cleaver O. Resolution of defective dorsal aortae patterning in Sema3E-deficient mice occurs via angiogenic remodeling. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 242: 580-90. PMID 23444297 DOI: 10.1002/dvdy.23949  1
2013 Degenhardt K, Singh MK, Epstein JA. New approaches under development: cardiovascular embryology applied to heart disease. The Journal of Clinical Investigation. 123: 71-4. PMID 23281412 DOI: 10.1172/JCI62884  1
2013 Padmanabhan A, Epstein JA. Zebrafish model for NF1 Neurofibromatosis Type 1: Molecular and Cellular Biology. 535-547. DOI: 10.1007/978-3-642-32864-0_35  1
2012 Yang Y, García-Verdugo JM, Soriano-Navarro M, Srinivasan RS, Scallan JP, Singh MK, Epstein JA, Oliver G. Lymphatic endothelial progenitors bud from the cardinal vein and intersomitic vessels in mammalian embryos. Blood. 120: 2340-8. PMID 22859612 DOI: 10.1182/blood-2012-05-428607  1
2012 Rentschler S, Yen AH, Lu J, Petrenko NB, Lu MM, Manderfield LJ, Patel VV, Fishman GI, Epstein JA. Myocardial Notch signaling reprograms cardiomyocytes to a conduction-like phenotype. Circulation. 126: 1058-66. PMID 22837163 DOI: 10.1161/CIRCULATIONAHA.112.103390  1
2012 Shin J, Padmanabhan A, de Groh ED, Lee JS, Haidar S, Dahlberg S, Guo F, He S, Wolman MA, Granato M, Lawson ND, Wolfe SA, Kim SH, Solnica-Krezel L, Kanki JP, ... ... Epstein JA, et al. Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development. Disease Models & Mechanisms. 5: 881-94. PMID 22773753 DOI: 10.1242/dmm.009779  1
2012 Singh MK, Epstein JA. Epicardium-derived cardiac mesenchymal stem cells: expanding the outer limit of heart repair. Circulation Research. 110: 904-6. PMID 22461359 DOI: 10.1161/RES.0b013e31825332a3  1
2012 Katz TC, Singh MK, Degenhardt K, Rivera-Feliciano J, Johnson RL, Epstein JA, Tabin CJ. Distinct compartments of the proepicardial organ give rise to coronary vascular endothelial cells. Developmental Cell. 22: 639-50. PMID 22421048 DOI: 10.1016/j.devcel.2012.01.012  1
2012 Engleka KA, Manderfield LJ, Brust RD, Li L, Cohen A, Dymecki SM, Epstein JA. Islet1 derivatives in the heart are of both neural crest and second heart field origin. Circulation Research. 110: 922-6. PMID 22394517 DOI: 10.1161/CIRCRESAHA.112.266510  1
2012 de la Pompa JL, Epstein JA. Coordinating tissue interactions: Notch signaling in cardiac development and disease. Developmental Cell. 22: 244-54. PMID 22340493 DOI: 10.1016/j.devcel.2012.01.014  1
2012 Zhang H, Qiao H, Frank RS, Huang B, Propert KJ, Margulies S, Ferrari VA, Epstein JA, Zhou R. Spin-labeling magnetic resonance imaging detects increased myocardial blood flow after endothelial cell transplantation in the infarcted heart. Circulation. Cardiovascular Imaging. 5: 210-7. PMID 22311739 DOI: 10.1161/CIRCIMAGING.111.966317  1
2012 Banerjee A, Trivedi CM, Damera G, Jiang M, Jester W, Hoshi T, Epstein JA, Panettieri RA. Trichostatin A abrogates airway constriction, but not inflammation, in murine and human asthma models. American Journal of Respiratory Cell and Molecular Biology. 46: 132-8. PMID 22298527 DOI: 10.1165/rcmb.2010-0276OC  1
2012 Manderfield LJ, High FA, Engleka KA, Liu F, Li L, Rentschler S, Epstein JA. Notch activation of Jagged1 contributes to the assembly of the arterial wall. Circulation. 125: 314-23. PMID 22147907 DOI: 10.1161/CIRCULATIONAHA.111.047159  1
2012 Boudou T, Legant WR, Mu A, Borochin MA, Thavandiran N, Radisic M, Zandstra PW, Epstein JA, Margulies KB, Chen CS. A microfabricated platform to measure and manipulate the mechanics of engineered cardiac microtissues. Tissue Engineering. Part A. 18: 910-9. PMID 22092279 DOI: 10.1089/ten.TEA.2011.0341  1
2011 Takeda N, Jain R, LeBoeuf MR, Wang Q, Lu MM, Epstein JA. Interconversion between intestinal stem cell populations in distinct niches. Science (New York, N.Y.). 334: 1420-4. PMID 22075725 DOI: 10.1126/science.1213214  1
2011 Singh MK, Lu MM, Massera D, Epstein JA. MicroRNA-processing enzyme Dicer is required in epicardium for coronary vasculature development. The Journal of Biological Chemistry. 286: 41036-45. PMID 21969379 DOI: 10.1074/jbc.M111.268573  1
2011 Singh N, Trivedi CM, Lu M, Mullican SE, Lazar MA, Epstein JA. Histone deacetylase 3 regulates smooth muscle differentiation in neural crest cells and development of the cardiac outflow tract. Circulation Research. 109: 1240-9. PMID 21959220 DOI: 10.1161/CIRCRESAHA.111.255067  1
2011 Zhu C, Smith T, McNulty J, Rayla AL, Lakshmanan A, Siekmann AF, Buffardi M, Meng X, Shin J, Padmanabhan A, Cifuentes D, Giraldez AJ, Look AT, Epstein JA, Lawson ND, et al. Evaluation and application of modularly assembled zinc-finger nucleases in zebrafish. Development (Cambridge, England). 138: 4555-64. PMID 21937602 DOI: 10.1242/dev.066779  1
2011 Li D, Epstein JA. Micro-managing myocyte mitosis. Circulation Research. 109: 611-3. PMID 21885834 DOI: 10.1161/CIRCRESAHA.111.252627  1
2011 Epstein JA. Politicizing NIH funding: a bridge to nowhere. The Journal of Clinical Investigation. 121: 3362-3. PMID 21881213 DOI: 10.1172/JCI60182  1
2011 Sun Z, Singh N, Mullican SE, Everett LJ, Li L, Yuan L, Liu X, Epstein JA, Lazar MA. Diet-induced lethality due to deletion of the Hdac3 gene in heart and skeletal muscle. The Journal of Biological Chemistry. 286: 33301-9. PMID 21808063 DOI: 10.1074/jbc.M111.277707  1
2011 Zygmunt T, Gay CM, Blondelle J, Singh MK, Flaherty KM, Means PC, Herwig L, Krudewig A, Belting HG, Affolter M, Epstein JA, Torres-Vázquez J. Semaphorin-PlexinD1 signaling limits angiogenic potential via the VEGF decoy receptor sFlt1. Developmental Cell. 21: 301-14. PMID 21802375 DOI: 10.1016/j.devcel.2011.06.033  1
2011 Lee T, Li YR, Chesi A, Hart MP, Ramos D, Jethava N, Hosangadi D, Epstein J, Hodges B, Bonini NM, Gitler AD. Evaluating the prevalence of polyglutamine repeat expansions in amyotrophic lateral sclerosis. Neurology. 76: 2062-5. PMID 21562248 DOI: 10.1212/WNL.0b013e31821f4447  1
2011 Epstein JA. Enhancing discovery and saving money with MERIT. The Journal of Clinical Investigation. 121: 1226. PMID 21490403 DOI: 10.1172/JCI57708  1
2011 Anokye-Danso F, Trivedi CM, Juhr D, Gupta M, Cui Z, Tian Y, Zhang Y, Yang W, Gruber PJ, Epstein JA, Morrisey EE. Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency. Cell Stem Cell. 8: 376-88. PMID 21474102 DOI: 10.1016/j.stem.2011.03.001  1
2011 Trivedi CM, Cappola TP, Margulies KB, Epstein JA. Homeodomain only protein x is down-regulated in human heart failure. Journal of Molecular and Cellular Cardiology. 50: 1056-8. PMID 21382376 DOI: 10.1016/j.yjmcc.2011.02.015  1
2011 Rentschler S, Harris BS, Kuznekoff L, Jain R, Manderfield L, Lu MM, Morley GE, Patel VV, Epstein JA. Notch signaling regulates murine atrioventricular conduction and the formation of accessory pathways. The Journal of Clinical Investigation. 121: 525-33. PMID 21266778 DOI: 10.1172/JCI44470  1
2011 Rentschler S, Epstein JA. Kicking the epicardium up a notch. Circulation Research. 108: 6-8. PMID 21212389 DOI: 10.1161/CIRCRESAHA.110.237297  1
2011 Trivedi CM, Epstein JA. Heart-healthy hypertrophy. Cell Metabolism. 13: 3-4. PMID 21195341 DOI: 10.1016/j.cmet.2010.12.012  1
2011 Jain R, Engleka KA, Rentschler SL, Manderfield LJ, Li L, Yuan L, Epstein JA. Cardiac neural crest orchestrates remodeling and functional maturation of mouse semilunar valves. The Journal of Clinical Investigation. 121: 422-30. PMID 21157040 DOI: 10.1172/JCI44244  1
2010 LeBoeuf M, Terrell A, Trivedi S, Sinha S, Epstein JA, Olson EN, Morrisey EE, Millar SE. Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells. Developmental Cell. 19: 807-18. PMID 21093383 DOI: 10.1016/j.devcel.2010.10.015  1
2010 Albrecht I, Niesner U, Janke M, Menning A, Loddenkemper C, Kühl AA, Lepenies I, Lexberg MH, Westendorf K, Hradilkova K, Grün J, Hamann A, Epstein JA, Chang HD, Tokoyoda K, et al. Persistence of effector memory Th1 cells is regulated by Hopx. European Journal of Immunology. 40: 2993-3006. PMID 21061432 DOI: 10.1002/eji.201040936  1
2010 Epstein JA. Franklin H. Epstein Lecture. Cardiac development and implications for heart disease. The New England Journal of Medicine. 363: 1638-47. PMID 20961247 DOI: 10.1056/NEJMra1003941  1
2010 Lee JS, Padmanabhan A, Shin J, Zhu S, Guo F, Kanki JP, Epstein JA, Look AT. Oligodendrocyte progenitor cell numbers and migration are regulated by the zebrafish orthologs of the NF1 tumor suppressor gene. Human Molecular Genetics. 19: 4643-53. PMID 20858602 DOI: 10.1093/hmg/ddq395  1
2010 Trivedi CM, Zhu W, Wang Q, Jia C, Kee HJ, Li L, Hannenhalli S, Epstein JA. Hopx and Hdac2 interact to modulate Gata4 acetylation and embryonic cardiac myocyte proliferation. Developmental Cell. 19: 450-9. PMID 20833366 DOI: 10.1016/j.devcel.2010.08.012  1
2010 Kapitsinou PP, Liu Q, Unger TL, Rha J, Davidoff O, Keith B, Epstein JA, Moores SL, Erickson-Miller CL, Haase VH. Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia. Blood. 116: 3039-48. PMID 20628150 DOI: 10.1182/blood-2010-02-270322  1
2010 Epstein J. Lessons of our fathers Journal of Clinical Investigation. 120: 2243-2247. PMID 20516648 DOI: 10.1172/JCI43606  1
2010 Stoller JZ, Huang L, Tan CC, Huang F, Zhou DD, Yang J, Gelb BD, Epstein JA. Ash2l interacts with Tbx1 and is required during early embryogenesis. Experimental Biology and Medicine (Maywood, N.J.). 235: 569-76. PMID 20463296 DOI: 10.1258/ebm.2010.009318  1
2010 Jain R, Rentschler S, Epstein JA. Notch and cardiac outflow tract development. Annals of the New York Academy of Sciences. 1188: 184-90. PMID 20201902 DOI: 10.1111/j.1749-6632.2009.05099.x  1
2010 Degenhardt K, Wright AC, Horng D, Padmanabhan A, Epstein JA. Rapid 3D phenotyping of cardiovascular development in mouse embryos by micro-CT with iodine staining. Circulation. Cardiovascular Imaging. 3: 314-22. PMID 20190279 DOI: 10.1161/CIRCIMAGING.109.918482  1
2010 Chokas AL, Trivedi CM, Lu MM, Tucker PW, Li S, Epstein JA, Morrisey EE. Foxp1/2/4-NuRD interactions regulate gene expression and epithelial injury response in the lung via regulation of interleukin-6. The Journal of Biological Chemistry. 285: 13304-13. PMID 20185820 DOI: 10.1074/jbc.M109.088468  1
2010 Degenhardt KR, Milewski RC, Padmanabhan A, Miller M, Singh MK, Lang D, Engleka KA, Wu M, Li J, Zhou D, Antonucci N, Li L, Epstein JA. Distinct enhancers at the Pax3 locus can function redundantly to regulate neural tube and neural crest expressions. Developmental Biology. 339: 519-27. PMID 20045680 DOI: 10.1016/j.ydbio.2009.12.030  1
2010 Rentschler S, Jain R, Epstein JA. Tissue-tissue interactions during morphogenesis of the outflow tract. Pediatric Cardiology. 31: 408-13. PMID 20039033 DOI: 10.1007/s00246-009-9611-2  1
2010 Singh MK, Li Y, Li S, Cobb RM, Zhou D, Lu MM, Epstein JA, Morrisey EE, Gruber PJ. Gata4 and Gata5 cooperatively regulate cardiac myocyte proliferation in mice. The Journal of Biological Chemistry. 285: 1765-72. PMID 19889636 DOI: 10.1074/jbc.M109.038539  1
2009 Epstein JA, Turka LA, Birnbaum M, Koretzky G. The physician's voice in the health care debate. The Journal of Clinical Investigation. 119: 2846. PMID 20069703 DOI: 10.1172/JCI40970  1
2009 Padmanabhan A, Lee JS, Ismat FA, Lu MM, Lawson ND, Kanki JP, Look AT, Epstein JA. Cardiac and vascular functions of the zebrafish orthologues of the type I neurofibromatosis gene NFI. Proceedings of the National Academy of Sciences of the United States of America. 106: 22305-10. PMID 19966217 DOI: 10.1073/pnas.0901932106  1
2009 Zhu W, Trivedi CM, Zhou D, Yuan L, Lu MM, Epstein JA. Inpp5f is a polyphosphoinositide phosphatase that regulates cardiac hypertrophic responsiveness. Circulation Research. 105: 1240-7. PMID 19875726 DOI: 10.1161/CIRCRESAHA.109.208785  1
2009 Levin MD, Lu MM, Petrenko NB, Hawkins BJ, Gupta TH, Lang D, Buckley PT, Jochems J, Liu F, Spurney CF, Yuan LJ, Jacobson JT, Brown CB, Huang L, Beermann F, ... ... Epstein JA, et al. Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers. The Journal of Clinical Investigation. 119: 3420-36. PMID 19855129 DOI: 10.1172/JCI39109  1
2009 Xu J, Ismat FA, Wang T, Lu MM, Antonucci N, Epstein JA. Cardiomyocyte-specific loss of neurofibromin promotes cardiac hypertrophy and dysfunction. Circulation Research. 105: 304-11. PMID 19574548 DOI: 10.1161/CIRCRESAHA.109.201509  1
2009 Parmacek MS, Epstein JA. Cardiomyocyte renewal. The New England Journal of Medicine. 361: 86-8. PMID 19571289 DOI: 10.1056/NEJMcibr0903347  1
2009 High FA, Jain R, Stoller JZ, Antonucci NB, Lu MM, Loomes KM, Kaestner KH, Pear WS, Epstein JA. Murine Jagged1/Notch signaling in the second heart field orchestrates Fgf8 expression and tissue-tissue interactions during outflow tract development. The Journal of Clinical Investigation. 119: 1986-96. PMID 19509466 DOI: 10.1172/JCI38922  1
2009 Epstein JA. Reinvestment and recovery. The Journal of Clinical Investigation. 119: 1398. PMID 19487815 DOI: 10.1172/JCI39701  1
2009 Aziz A, Miyake T, Engleka KA, Epstein JA, McDermott JC. Menin expression modulates mesenchymal cell commitment to the myogenic and osteogenic lineages. Developmental Biology. 332: 116-30. PMID 19464283 DOI: 10.1016/j.ydbio.2009.05.555  1
2009 Nishijo K, Hosoyama T, Bjornson CR, Schaffer BS, Prajapati SI, Bahadur AN, Hansen MS, Blandford MC, McCleish AT, Rubin BP, Epstein JA, Rando TA, Capecchi MR, Keller C. Biomarker system for studying muscle, stem cells, and cancer in vivo. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 2681-90. PMID 19332644 DOI: 10.1096/fj.08-128116  1
2009 Epstein JA, Niemitz EL. Stem cells by the shore: Meeting summary of the 2008 MDI Stem Cell Symposium. Epigenetics. 4: 125-6. PMID 19305143 DOI: 10.4161/epi.4.2.7735  1
2009 Griffith AV, Cardenas K, Carter C, Gordon J, Iberg A, Engleka K, Epstein JA, Manley NR, Richie ER. Increased thymus- and decreased parathyroid-fated organ domains in Splotch mutant embryos. Developmental Biology. 327: 216-27. PMID 19135046 DOI: 10.1016/j.ydbio.2008.12.019  1
2009 Zhang Y, Singh MK, Degenhardt KR, Lu MM, Bennett J, Yoshida Y, Epstein JA. Tie2Cre-mediated inactivation of plexinD1 results in congenital heart, vascular and skeletal defects. Developmental Biology. 325: 82-93. PMID 18992737 DOI: 10.1016/j.ydbio.2008.09.031  1
2009 Epstein JA. Currying favor for the heart (Journal of Clinical Investigation (2008) 118, (850-852) DOI: 10.1172/JCI34650) Journal of Clinical Investigation. 119: 2113.  1
2008 Choi YI, Duke-Cohan JS, Ahmed WB, Handley MA, Mann F, Epstein JA, Clayton LK, Reinherz EL. PlexinD1 glycoprotein controls migration of positively selected thymocytes into the medulla. Immunity. 29: 888-98. PMID 19027330 DOI: 10.1016/j.immuni.2008.10.008  1
2008 Liu F, Levin MD, Petrenko NB, Lu MM, Wang T, Yuan LJ, Stout AL, Epstein JA, Patel VV. Histone-deacetylase inhibition reverses atrial arrhythmia inducibility and fibrosis in cardiac hypertrophy independent of angiotensin. Journal of Molecular and Cellular Cardiology. 45: 715-23. PMID 18926829 DOI: 10.1016/j.yjmcc.2008.08.015  1
2008 Kerkela R, Kockeritz L, Macaulay K, Zhou J, Doble BW, Beahm C, Greytak S, Woulfe K, Trivedi CM, Woodgett JR, Epstein JA, Force T, Huggins GS. Deletion of GSK-3beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation. The Journal of Clinical Investigation. 118: 3609-18. PMID 18830417 DOI: 10.1172/JCI36245  1
2008 Trivedi CM, Lu MM, Wang Q, Epstein JA. Transgenic overexpression of Hdac3 in the heart produces increased postnatal cardiac myocyte proliferation but does not induce hypertrophy. The Journal of Biological Chemistry. 283: 26484-9. PMID 18625706 DOI: 10.1074/jbc.M803686200  1
2008 Granger A, Abdullah I, Huebner F, Stout A, Wang T, Huebner T, Epstein JA, Gruber PJ. Histone deacetylase inhibition reduces myocardial ischemia-reperfusion injury in mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 3549-60. PMID 18606865 DOI: 10.1096/fj.08-108548  1
2008 Lagha M, Kormish JD, Rocancourt D, Manceau M, Epstein JA, Zaret KS, Relaix F, Buckingham ME. Pax3 regulation of FGF signaling affects the progression of embryonic progenitor cells into the myogenic program. Genes & Development. 22: 1828-37. PMID 18593883 DOI: 10.1101/gad.477908  1
2008 Wu M, Li J, Engleka KA, Zhou B, Lu MM, Plotkin JB, Epstein JA. Persistent expression of Pax3 in the neural crest causes cleft palate and defective osteogenesis in mice. The Journal of Clinical Investigation. 118: 2076-87. PMID 18483623 DOI: 10.1172/JCI33715  1
2008 Stoller JZ, Degenhardt KR, Huang L, Zhou DD, Lu MM, Epstein JA. Cre reporter mouse expressing a nuclear localized fusion of GFP and beta-galactosidase reveals new derivatives of Pax3-expressing precursors. Genesis (New York, N.Y. : 2000). 46: 200-4. PMID 18395835 DOI: 10.1002/dvg.20384  0.48
2008 High FA, Lu MM, Pear WS, Loomes KM, Kaestner KH, Epstein JA. Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development. Proceedings of the National Academy of Sciences of the United States of America. 105: 1955-9. PMID 18245384 DOI: 10.1073/pnas.0709663105  1
2008 Hori K, Cholewa-Waclaw J, Nakada Y, Glasgow SM, Masui T, Henke RM, Wildner H, Martarelli B, Beres TM, Epstein JA, Magnuson MA, Macdonald RJ, Birchmeier C, Johnson JE. A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling. Genes & Development. 22: 166-78. PMID 18198335 DOI: 10.1101/gad.1628008  1
2008 Huang J, Cheng L, Li J, Chen M, Zhou D, Lu MM, Proweller A, Epstein JA, Parmacek MS. Myocardin regulates expression of contractile genes in smooth muscle cells and is required for closure of the ductus arteriosus in mice. The Journal of Clinical Investigation. 118: 515-25. PMID 18188448 DOI: 10.1172/JCI33304  1
2008 High FA, Epstein JA. The multifaceted role of Notch in cardiac development and disease. Nature Reviews. Genetics. 9: 49-61. PMID 18071321 DOI: 10.1038/nrg2279  1
2007 High F, Epstein JA. Signalling pathways regulating cardiac neural crest migration and differentiation. Novartis Foundation Symposium. 283: 152-61; discussion 1. PMID 18300420  1
2007 Engleka KA, Wu M, Zhang M, Antonucci NB, Epstein JA. Menin is required in cranial neural crest for palatogenesis and perinatal viability. Developmental Biology. 311: 524-37. PMID 17927973 DOI: 10.1016/j.ydbio.2007.08.057  0.48
2007 Vasyutina E, Lenhard DC, Wende H, Erdmann B, Epstein JA, Birchmeier C. RBP-J (Rbpsuh) is essential to maintain muscle progenitor cells and to generate satellite cells. Proceedings of the National Academy of Sciences of the United States of America. 104: 4443-8. PMID 17360543 DOI: 10.1073/pnas.0610647104  1
2007 Trivedi CM, Luo Y, Yin Z, Zhang M, Zhu W, Wang T, Floss T, Goettlicher M, Noppinger PR, Wurst W, Ferrari VA, Abrams CS, Gruber PJ, Epstein JA. Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity. Nature Medicine. 13: 324-31. PMID 17322895 DOI: 10.1038/nm1552  1
2007 High FA, Zhang M, Proweller A, Tu L, Parmacek MS, Pear WS, Epstein JA. An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation. The Journal of Clinical Investigation. 117: 353-63. PMID 17273555 DOI: 10.1172/JCI30070  1
2006 Luo Y, High FA, Epstein JA, Radice GL. N-cadherin is required for neural crest remodeling of the cardiac outflow tract. Developmental Biology. 299: 517-28. PMID 17014840 DOI: 10.1016/j.ydbio.2006.09.003  1
2006 Hannenhalli S, Putt ME, Gilmore JM, Wang J, Parmacek MS, Epstein JA, Morrisey EE, Margulies KB, Cappola TP. Transcriptional genomics associates FOX transcription factors with human heart failure. Circulation. 114: 1269-76. PMID 16952980 DOI: 10.1161/CIRCULATIONAHA.106.632430  1
2006 Kook H, Yung WW, Simpson RJ, Kee HJ, Shin S, Lowry JA, Loughlin FE, Yin Z, Epstein JA, Mackay JP. Analysis of the structure and function of the transcriptional coregulator HOP. Biochemistry. 45: 10584-90. PMID 16939210 DOI: 10.1021/bi060641s  1
2006 Ismat FA, Xu J, Lu MM, Epstein JA. The neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1 mice. The Journal of Clinical Investigation. 116: 2378-84. PMID 16906226 DOI: 10.1172/JCI28341  0.32
2005 Engleka KA, Gitler AD, Zhang M, Zhou DD, High FA, Epstein JA. Insertion of Cre into the Pax3 locus creates a new allele of Splotch and identifies unexpected Pax3 derivatives. Developmental Biology. 280: 396-406. PMID 15882581 DOI: 10.1016/j.ydbio.2005.02.002  1
2004 Torres-Vázquez J, Gitler AD, Fraser SD, Berk JD, Van N Pham, Fishman MC, Childs S, Epstein JA, Weinstein BM. Semaphorin-plexin signaling guides patterning of the developing vasculature. Developmental Cell. 7: 117-23. PMID 15239959 DOI: 10.1016/j.devcel.2004.06.008  1
2004 Gitler AD, Lu MM, Epstein JA. PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development. Developmental Cell. 7: 107-16. PMID 15239958 DOI: 10.1016/j.devcel.2004.06.002  1
2004 Gitler AD, Kong Y, Choi JK, Zhu Y, Pear WS, Epstein JA. Tie2-Cre-induced inactivation of a conditional mutant Nf1 allele in mouse results in a myeloproliferative disorder that models juvenile myelomonocytic leukemia. Pediatric Research. 55: 581-4. PMID 14739366 DOI: 10.1203/01.PDR.0000113462.98851.2E  1
2004 Milewski RC, Chi NC, Li J, Brown C, Lu MM, Epstein JA. Identification of minimal enhancer elements sufficient for Pax3 expression in neural crest and implication of Tead2 as a regulator of Pax3. Development (Cambridge, England). 131: 829-37. PMID 14736747 DOI: 10.1242/dev.00975  1
2003 Gitler AD, Lu MM, Jiang YQ, Epstein JA, Gruber PJ. Molecular markers of cardiac endocardial cushion development. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 228: 643-50. PMID 14648841 DOI: 10.1002/dvdy.10418  1
2003 Kook H, Lepore JJ, Gitler AD, Lu MM, Wing-Man Yung W, Mackay J, Zhou R, Ferrari V, Gruber P, Epstein JA. Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop. The Journal of Clinical Investigation. 112: 863-71. PMID 12975471 DOI: 10.1172/JCI19137  1
2003 Gitler AD, Epstein JA. Regulating heart development: the role of Nf1. Cell Cycle (Georgetown, Tex.). 2: 96-8. PMID 12695655  1
2003 Gitler AD, Zhu Y, Ismat FA, Lu MM, Yamauchi Y, Parada LF, Epstein JA. Nf1 has an essential role in endothelial cells. Nature Genetics. 33: 75-9. PMID 12469121 DOI: 10.1038/ng1059  1
2002 Gitler AD, Brown CB, Kochilas L, Li J, Epstein JA. Neural crest migration and mouse models of congenital heart disease. Cold Spring Harbor Symposia On Quantitative Biology. 67: 57-62. PMID 12858524  1
2002 Chen F, Kook H, Milewski R, Gitler AD, Lu MM, Li J, Nazarian R, Schnepp R, Jen K, Biben C, Runke G, Mackay JP, Novotny J, Schwartz RJ, Harvey RP, ... ... Epstein JA, et al. Hop is an unusual homeobox gene that modulates cardiac development. Cell. 110: 713-23. PMID 12297045 DOI: 10.1016/S0092-8674(02)00932-7  1
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