Jonathan A. Epstein - Publications

Affiliations: 
2004 University of Pennsylvania, Philadelphia, PA, United States 

196 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Jang J, Engleka KA, Liu F, Li L, Song G, Epstein JA, Li D. An Engineered Mouse to Identify Proliferating Cells and Their Derivatives. Frontiers in Cell and Developmental Biology. 8: 388. PMID 32523954 DOI: 10.3389/Fcell.2020.00388  0.333
2019 Poleshko A, Smith CL, Nguyen SC, Sivaramakrishnan P, Wong KG, Murray JI, Lakadamyali M, Joyce EF, Jain R, Epstein JA. H3K9me2 orchestrates inheritance of spatial positioning of peripheral heterochromatin through mitosis. Elife. 8. PMID 31573510 DOI: 10.7554/Elife.49278  0.3
2019 Aghajanian H, Kimura T, Rurik JG, Hancock AS, Leibowitz MS, Li L, Scholler J, Monslow J, Lo A, Han W, Wang T, Bedi K, Morley MP, Linares Saldana RA, Bolar NA, ... ... Epstein JA, et al. Targeting cardiac fibrosis with engineered T cells. Nature. PMID 31511695 DOI: 10.1038/S41586-019-1546-Z  0.4
2019 Sandireddy R, Cibi DM, Gupta P, Singh A, Tee N, Uemura A, Epstein JA, Singh MK. Semaphorin 3E/PlexinD1 signaling is required for cardiac ventricular compaction. Jci Insight. 4. PMID 31434798 DOI: 10.1172/Jci.Insight.125908  0.445
2019 Berg DA, Su Y, Jimenez-Cyrus D, Patel A, Huang N, Morizet D, Lee S, Shah R, Ringeling FR, Jain R, Epstein JA, Wu QF, Canzar S, Ming GL, Song H, et al. A Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis. Cell. PMID 30929900 DOI: 10.1016/J.Cell.2019.02.010  0.34
2019 See K, Lan Y, Rhoades J, Jain R, Smith CL, Epstein JA. Lineage-specific reorganization of nuclear peripheral heterochromatin and H3K9me2 domains. Development (Cambridge, England). 146. PMID 30723106 DOI: 10.1242/Dev.174078  0.404
2019 Sandireddy R, Cibi DM, Singh A, Tee N, Uemura A, Epstein JA, Singh MK. Abstract 633: Semaphorin3e-Plexind1 Signaling is Required for Cardiac Ventricular Compaction Circulation Research. 125. DOI: 10.1161/Res.125.Suppl_1.633  0.346
2018 Jain R, Poleshko A, Epstein JA. Beating the odds: programming proliferation in the mammalian heart. Genome Medicine. 10: 36. PMID 29776422 DOI: 10.1186/S13073-018-0550-5  0.375
2018 Artap S, Manderfield LJ, Smith CL, Poleshko A, Aghajanian H, See K, Li L, Jain R, Epstein JA. Endocardial Hippo signaling regulates myocardial growth and cardiogenesis. Developmental Biology. PMID 29727635 DOI: 10.1016/J.Ydbio.2018.04.026  0.401
2018 Jain R, Epstein JA. Competent for commitment: you've got to have heart! Genes & Development. 32: 4-13. PMID 29440224 DOI: 10.1101/Gad.308353.117  0.447
2018 Lin W, Li D, Cheng L, Li L, Liu F, Hand NJ, Epstein JA, Rader DJ. Zinc transporter Slc39a8 is essential for cardiac ventricular compaction. The Journal of Clinical Investigation. PMID 29337306 DOI: 10.1172/Jci96993  0.429
2017 Poleshko A, Shah PP, Gupta M, Babu A, Morley MP, Manderfield LJ, Ifkovits JL, Calderon D, Aghajanian H, Sierra-Pagán JE, Sun Z, Wang Q, Li L, Dubois NC, Morrisey EE, ... ... Epstein JA, et al. Genome-Nuclear Lamina Interactions Regulate Cardiac Stem Cell Lineage Restriction. Cell. PMID 29033129 DOI: 10.1016/J.Cell.2017.09.018  0.427
2017 Pauerstein PT, Tellez K, Willmarth KB, Park KM, Hsueh B, Arda HE, Gu X, Aghajanian H, Deisseroth K, Epstein JA, Kim SK. A radial axis defined by Semaphorin to Neuropilin signaling controls pancreatic islet morphogenesis. Development (Cambridge, England). PMID 28893946 DOI: 10.1242/Dev.148684  0.35
2017 Palpant NJ, Wang Y, Hadland B, Zaunbrecher RJ, Redd M, Jones D, Pabon L, Jain R, Epstein J, Ruzzo WL, Zheng Y, Bernstein I, Margolin A, Murry CE. Chromatin and Transcriptional Analysis of Mesoderm Progenitor Cells Identifies HOPX as a Regulator of Primitive Hematopoiesis. Cell Reports. 20: 1597-1608. PMID 28813672 DOI: 10.1016/J.Celrep.2017.07.067  0.301
2017 Bardot E, Calderon D, Santoriello F, Han S, Cheung K, Jadhav B, Burtscher I, Artap S, Jain R, Epstein J, Lickert H, Gouon-Evans V, Sharp AJ, Dubois NC. Foxa2 identifies a cardiac progenitor population with ventricular differentiation potential. Nature Communications. 8: 14428. PMID 28195173 DOI: 10.1038/ncomms14428  0.302
2017 Ramjee V, Li D, Manderfield LJ, Liu F, Engleka KA, Aghajanian H, Rodell CB, Lu W, Ho V, Wang T, Li L, Singh A, Cibi DM, Burdick JA, Singh MK, ... ... Epstein JA, et al. Epicardial YAP/TAZ orchestrate an immunosuppressive response following myocardial infarction. The Journal of Clinical Investigation. PMID 28165342 DOI: 10.1172/Jci88759  0.354
2016 Loh KM, Chen A, Koh PW, Deng TZ, Sinha R, Tsai JM, Barkal AA, Shen KY, Jain R, Morganti RM, Shyh-Chang N, Fernhoff NB, George BM, Wernig G, Salomon RE, ... ... Epstein JA, et al. Mapping the Pairwise Choices Leading from Pluripotency to Human Bone, Heart, and Other Mesoderm Cell Types. Cell. 166: 451-467. PMID 27419872 DOI: 10.1016/J.Cell.2016.06.011  0.391
2016 Aghajanian H, Cho YK, Manderfield LJ, Herling MR, Gupta M, Ho VC, Li L, Degenhardt K, Aharonov A, Tzahor E, Epstein JA. Coronary vasculature patterning requires a novel endothelial ErbB2 holoreceptor. Nature Communications. 7: 12038. PMID 27356767 DOI: 10.1038/Ncomms12038  0.315
2016 Singh A, Ramesh S, Cibi DM, Yun LS, Li J, Li L, Manderfield LJ, Olson EN, Epstein JA, Singh MK. Hippo Signaling Mediators Yap and Taz Are Required in the Epicardium for Coronary Vasculature Development. Cell Reports. PMID 27160901 DOI: 10.1016/J.Celrep.2016.04.027  0.401
2016 He S, Mansour MR, Zimmerman MW, Ki DH, Layden HM, Akahane K, Gjini E, de Groh ED, Perez-Atayde AR, Zhu S, Epstein JA, Look AT. Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain. Elife. 5. PMID 27130733 DOI: 10.7554/Elife.14713  0.353
2016 He S, Mansour MR, Zimmerman MW, Ki DH, Layden HM, Akahane K, Groh EDd, Perez-Atayde AR, Zhu S, Epstein JA, Look AT. Abstract 2456: Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain Cancer Research. 76: 2456-2456. DOI: 10.1158/1538-7445.Am2016-2456  0.346
2015 Manderfield LJ, Engleka KA, Aghajanian H, Gupta M, Yang S, Li L, Baggs JE, Hogenesch JB, Olson EN, Epstein JA. Pax3 and Hippo Signaling Coordinate Melanocyte Gene Expression in Neural Crest. Cell Reports. 10: 841. PMID 30849859 DOI: 10.1016/J.Celrep.2015.01.041  0.382
2015 Yzaguirre AD, Padmanabhan A, de Groh ED, Engleka KA, Li J, Speck NA, Epstein JA. Loss of neurofibromin Ras-GAP activity enhances the formation of cardiac blood islands in murine embryos. Elife. 4. PMID 26460546 DOI: 10.7554/Elife.07780  0.635
2015 Li D, Takeda N, Jain R, Manderfield LJ, Liu F, Li L, Anderson SA, Epstein JA. Hopx distinguishes hippocampal from lateral ventricle neural stem cells. Stem Cell Research. 15: 522-529. PMID 26451648 DOI: 10.1016/J.Scr.2015.09.015  0.395
2015 Manderfield LJ, Aghajanian H, Engleka KA, Lim LY, Lui F, Jain R, Li L, Olson EN, Epstein JA. Hippo signaling is required for Notch-dependent smooth muscle differentiation of neural crest. Development (Cambridge, England). PMID 26253400 DOI: 10.1242/Dev.125807  0.397
2015 Jain R, Li D, Gupta M, Manderfield LJ, Ifkovits JL, Wang Q, Liu F, Liu Y, Poleshko A, Padmanabhan A, Raum JC, Li L, Morrisey EE, Lu MM, Won KJ, ... Epstein JA, et al. HEART DEVELOPMENT. Integration of Bmp and Wnt signaling by Hopx specifies commitment of cardiomyoblasts. Science (New York, N.Y.). 348: aaa6071. PMID 26113728 DOI: 10.1126/Science.Aaa6071  0.651
2015 Tomas-Roca L, Tsaalbi-Shtylik A, Jansen JG, Singh MK, Epstein JA, Altunoglu U, Verzijl H, Soria L, van Beusekom E, Roscioli T, Iqbal Z, Gilissen C, Hoischen A, de Brouwer AP, Erasmus C, et al. De novo mutations in PLXND1 and REV3L cause Möbius syndrome. Nature Communications. 6: 7199. PMID 26068067 DOI: 10.1038/Ncomms8199  0.325
2015 Zhou X, Crow AL, Hartiala J, Spindler TJ, Ghazalpour A, Barsky LW, Bennett BB, Parks BW, Eskin E, Jain R, Epstein JA, Lusis AJ, Adams GB, Allayee H. The Genetic Landscape of Hematopoietic Stem Cell Frequency in Mice. Stem Cell Reports. PMID 26050929 DOI: 10.1016/J.Stemcr.2015.05.008  0.347
2015 Han SS, Zhang R, Jain R, Shi H, Zhang L, Zhou G, Sangwung P, Tugal D, Atkins GB, Prosdocimo DA, Lu Y, Han X, Tso P, Liao X, Epstein JA, et al. Circadian control of bile acid synthesis by a KLF15-Fgf15 axis. Nature Communications. 6: 7231. PMID 26040986 DOI: 10.1038/Ncomms8231  0.3
2015 Jain R, Barkauskas CE, Takeda N, Bowie EJ, Aghajanian H, Wang Q, Padmanabhan A, Manderfield LJ, Gupta M, Li D, Li L, Trivedi CM, Hogan BL, Epstein JA. Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung. Nature Communications. 6: 6727. PMID 25865356 DOI: 10.1038/Ncomms7727  0.575
2015 Epstein JA, Aghajanian H, Singh MK. Semaphorin signaling in cardiovascular development. Cell Metabolism. 21: 163-73. PMID 25651171 DOI: 10.1016/J.Cmet.2014.12.015  0.363
2015 Yzaguirre AD, Padmanabhan A, Groh EDd, Engleka KA, Li J, Speck NA, Epstein JA. Author response: Loss of neurofibromin Ras-GAP activity enhances the formation of cardiac blood islands in murine embryos Elife. DOI: 10.7554/Elife.07780.016  0.579
2014 Manderfield LJ, Engleka KA, Aghajanian H, Gupta M, Yang S, Li L, Baggs JE, Hogenesch JB, Olson EN, Epstein JA. Pax3 and hippo signaling coordinate melanocyte gene expression in neural crest. Cell Reports. 9: 1885-95. PMID 25466249 DOI: 10.1016/J.Celrep.2014.10.061  0.447
2014 Li N, Yousefi M, Nakauka-Ddamba A, Jain R, Tobias J, Epstein JA, Jensen ST, Lengner CJ. Single-cell analysis of proxy reporter allele-marked epithelial cells establishes intestinal stem cell hierarchy. Stem Cell Reports. 3: 876-91. PMID 25418730 DOI: 10.1016/J.Stemcr.2014.09.011  0.306
2014 Chen HI, Sharma B, Akerberg BN, Numi HJ, Kivelä R, Saharinen P, Aghajanian H, McKay AS, Bogard PE, Chang AH, Jacobs AH, Epstein JA, Stankunas K, Alitalo K, Red-Horse K. The sinus venosus contributes to coronary vasculature through VEGFC-stimulated angiogenesis. Development (Cambridge, England). 141: 4500-12. PMID 25377552 DOI: 10.1242/Dev.113639  0.328
2014 Aghajanian H, Choi C, Ho VC, Gupta M, Singh MK, Epstein JA. Semaphorin 3d and semaphorin 3e direct endothelial motility through distinct molecular signaling pathways. The Journal of Biological Chemistry. 289: 17971-9. PMID 24825896 DOI: 10.1074/Jbc.M113.544833  0.325
2014 Gerhardt DM, Pajcini KV, D'altri T, Tu L, Jain R, Xu L, Chen MJ, Rentschler S, Shestova O, Wertheim GB, Tobias JW, Kluk M, Wood AW, Aster JC, Gimotty PA, ... Epstein JA, et al. The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells. Genes & Development. 28: 576-93. PMID 24637115 DOI: 10.1101/Gad.227496.113  0.422
2014 Ifkovits JL, Addis RC, Epstein JA, Gearhart JD. Inhibition of TGFβ signaling increases direct conversion of fibroblasts to induced cardiomyocytes. Plos One. 9: e89678. PMID 24586958 DOI: 10.1371/Journal.Pone.0089678  0.418
2014 Worzfeld T, Swiercz JM, Sentürk A, Genz B, Korostylev A, Deng S, Xia J, Hoshino M, Epstein JA, Chan AM, Vollmar B, Acker-Palmer A, Kuner R, Offermanns S. Genetic dissection of plexin signaling in vivo. Proceedings of the National Academy of Sciences of the United States of America. 111: 2194-9. PMID 24469813 DOI: 10.1073/Pnas.1308418111  0.362
2014 Zhao T, Gan Q, Stokes A, Lassiter RN, Wang Y, Chan J, Han JX, Pleasure DE, Epstein JA, Zhou CJ. β-catenin regulates Pax3 and Cdx2 for caudal neural tube closure and elongation. Development (Cambridge, England). 141: 148-57. PMID 24284205 DOI: 10.1242/Dev.101550  0.412
2013 Choi YI, Duke-Cohan JS, Tan J, Gui J, Singh MK, Epstein JA, Reinherz EL. Plxnd1 expression in thymocytes regulates their intrathymic migration while that in thymic endothelium impacts medullary topology. Frontiers in Immunology. 4: 392. PMID 24312099 DOI: 10.3389/Fimmu.2013.00392  0.408
2013 Addis RC, Epstein JA. Induced regeneration--the progress and promise of direct reprogramming for heart repair. Nature Medicine. 19: 829-36. PMID 23836233 DOI: 10.1038/Nm.3225  0.366
2013 Takeda N, Jain R, Li D, Li L, Lu MM, Epstein JA. Lgr5 Identifies Progenitor Cells Capable of Taste Bud Regeneration after Injury. Plos One. 8: e66314. PMID 23824276 DOI: 10.1371/Journal.Pone.0066314  0.323
2013 Addis RC, Ifkovits JL, Pinto F, Kellam LD, Esteso P, Rentschler S, Christoforou N, Epstein JA, Gearhart JD. Optimization of direct fibroblast reprogramming to cardiomyocytes using calcium activity as a functional measure of success. Journal of Molecular and Cellular Cardiology. 60: 97-106. PMID 23591016 DOI: 10.1016/J.Yjmcc.2013.04.004  0.315
2013 Singh N, Gupta M, Trivedi CM, Singh MK, Li L, Epstein JA. Murine craniofacial development requires Hdac3-mediated repression of Msx gene expression. Developmental Biology. 377: 333-44. PMID 23506836 DOI: 10.1016/J.Ydbio.2013.03.008  0.605
2013 Parmacek MS, Epstein JA. An epigenetic roadmap for cardiomyocyte differentiation. Circulation Research. 112: 881-3. PMID 23493303 DOI: 10.1161/Circresaha.113.301134  0.419
2013 Takeda N, Jain R, Leboeuf MR, Padmanabhan A, Wang Q, Li L, Lu MM, Millar SE, Epstein JA. Hopx expression defines a subset of multipotent hair follicle stem cells and a progenitor population primed to give rise to K6+ niche cells. Development (Cambridge, England). 140: 1655-64. PMID 23487314 DOI: 10.1242/Dev.093005  0.594
2013 Meadows SM, Ratliff LA, Singh MK, Epstein JA, Cleaver O. Resolution of defective dorsal aortae patterning in Sema3E-deficient mice occurs via angiogenic remodeling. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 242: 580-90. PMID 23444297 DOI: 10.1002/Dvdy.23949  0.336
2013 Degenhardt K, Singh MK, Epstein JA. New approaches under development: cardiovascular embryology applied to heart disease. The Journal of Clinical Investigation. 123: 71-4. PMID 23281412 DOI: 10.1172/Jci62884  0.331
2013 Padmanabhan A, Epstein JA. Zebrafish model for NF1 Neurofibromatosis Type 1: Molecular and Cellular Biology. 535-547. DOI: 10.1007/978-3-642-32864-0_35  0.48
2012 Yang Y, García-Verdugo JM, Soriano-Navarro M, Srinivasan RS, Scallan JP, Singh MK, Epstein JA, Oliver G. Lymphatic endothelial progenitors bud from the cardinal vein and intersomitic vessels in mammalian embryos. Blood. 120: 2340-8. PMID 22859612 DOI: 10.1182/Blood-2012-05-428607  0.369
2012 Rentschler S, Yen AH, Lu J, Petrenko NB, Lu MM, Manderfield LJ, Patel VV, Fishman GI, Epstein JA. Myocardial Notch signaling reprograms cardiomyocytes to a conduction-like phenotype. Circulation. 126: 1058-66. PMID 22837163 DOI: 10.1161/Circulationaha.112.103390  0.396
2012 Shin J, Padmanabhan A, de Groh ED, Lee JS, Haidar S, Dahlberg S, Guo F, He S, Wolman MA, Granato M, Lawson ND, Wolfe SA, Kim SH, Solnica-Krezel L, Kanki JP, ... ... Epstein JA, et al. Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development. Disease Models & Mechanisms. 5: 881-94. PMID 22773753 DOI: 10.1242/Dmm.009779  0.609
2012 Singh MK, Epstein JA. Epicardium-derived cardiac mesenchymal stem cells: expanding the outer limit of heart repair. Circulation Research. 110: 904-6. PMID 22461359 DOI: 10.1161/Res.0B013E31825332A3  0.43
2012 Katz TC, Singh MK, Degenhardt K, Rivera-Feliciano J, Johnson RL, Epstein JA, Tabin CJ. Distinct compartments of the proepicardial organ give rise to coronary vascular endothelial cells. Developmental Cell. 22: 639-50. PMID 22421048 DOI: 10.1016/J.Devcel.2012.01.012  0.372
2012 Engleka KA, Manderfield LJ, Brust RD, Li L, Cohen A, Dymecki SM, Epstein JA. Islet1 derivatives in the heart are of both neural crest and second heart field origin. Circulation Research. 110: 922-6. PMID 22394517 DOI: 10.1161/Circresaha.112.266510  0.431
2012 de la Pompa JL, Epstein JA. Coordinating tissue interactions: Notch signaling in cardiac development and disease. Developmental Cell. 22: 244-54. PMID 22340493 DOI: 10.1016/J.Devcel.2012.01.014  0.452
2012 Manderfield LJ, High FA, Engleka KA, Liu F, Li L, Rentschler S, Epstein JA. Notch activation of Jagged1 contributes to the assembly of the arterial wall. Circulation. 125: 314-23. PMID 22147907 DOI: 10.1161/Circulationaha.111.047159  0.711
2012 Boudou T, Legant WR, Mu A, Borochin MA, Thavandiran N, Radisic M, Zandstra PW, Epstein JA, Margulies KB, Chen CS. A microfabricated platform to measure and manipulate the mechanics of engineered cardiac microtissues. Tissue Engineering. Part A. 18: 910-9. PMID 22092279 DOI: 10.1089/Ten.Tea.2011.0341  0.321
2012 Epstein JA. Pax3, neural crest and cardiovascular development. Trends in Cardiovascular Medicine. 6: 255-60. PMID 21232305 DOI: 10.1016/S1050-1738(96)00110-7  0.421
2011 Takeda N, Jain R, LeBoeuf MR, Wang Q, Lu MM, Epstein JA. Interconversion between intestinal stem cell populations in distinct niches. Science (New York, N.Y.). 334: 1420-4. PMID 22075725 DOI: 10.1126/Science.1213214  0.313
2011 Singh MK, Lu MM, Massera D, Epstein JA. MicroRNA-processing enzyme Dicer is required in epicardium for coronary vasculature development. The Journal of Biological Chemistry. 286: 41036-45. PMID 21969379 DOI: 10.1074/Jbc.M111.268573  0.385
2011 Singh N, Trivedi CM, Lu M, Mullican SE, Lazar MA, Epstein JA. Histone deacetylase 3 regulates smooth muscle differentiation in neural crest cells and development of the cardiac outflow tract. Circulation Research. 109: 1240-9. PMID 21959220 DOI: 10.1161/Circresaha.111.255067  0.605
2011 Zhu C, Smith T, McNulty J, Rayla AL, Lakshmanan A, Siekmann AF, Buffardi M, Meng X, Shin J, Padmanabhan A, Cifuentes D, Giraldez AJ, Look AT, Epstein JA, Lawson ND, et al. Evaluation and application of modularly assembled zinc-finger nucleases in zebrafish. Development (Cambridge, England). 138: 4555-64. PMID 21937602 DOI: 10.1242/Dev.066779  0.577
2011 Li D, Epstein JA. Micro-managing myocyte mitosis. Circulation Research. 109: 611-3. PMID 21885834 DOI: 10.1161/Circresaha.111.252627  0.395
2011 Sun Z, Singh N, Mullican SE, Everett LJ, Li L, Yuan L, Liu X, Epstein JA, Lazar MA. Diet-induced lethality due to deletion of the Hdac3 gene in heart and skeletal muscle. The Journal of Biological Chemistry. 286: 33301-9. PMID 21808063 DOI: 10.1074/Jbc.M111.277707  0.569
2011 Zygmunt T, Gay CM, Blondelle J, Singh MK, Flaherty KM, Means PC, Herwig L, Krudewig A, Belting HG, Affolter M, Epstein JA, Torres-Vázquez J. Semaphorin-PlexinD1 signaling limits angiogenic potential via the VEGF decoy receptor sFlt1. Developmental Cell. 21: 301-14. PMID 21802375 DOI: 10.1016/J.Devcel.2011.06.033  0.304
2011 Lee T, Li YR, Chesi A, Hart MP, Ramos D, Jethava N, Hosangadi D, Epstein J, Hodges B, Bonini NM, Gitler AD. Evaluating the prevalence of polyglutamine repeat expansions in amyotrophic lateral sclerosis. Neurology. 76: 2062-5. PMID 21562248 DOI: 10.1212/Wnl.0B013E31821F4447  0.717
2011 Anokye-Danso F, Trivedi CM, Juhr D, Gupta M, Cui Z, Tian Y, Zhang Y, Yang W, Gruber PJ, Epstein JA, Morrisey EE. Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency. Cell Stem Cell. 8: 376-88. PMID 21474102 DOI: 10.1016/J.Stem.2011.03.001  0.312
2011 Trivedi CM, Cappola TP, Margulies KB, Epstein JA. Homeodomain only protein x is down-regulated in human heart failure. Journal of Molecular and Cellular Cardiology. 50: 1056-8. PMID 21382376 DOI: 10.1016/J.Yjmcc.2011.02.015  0.392
2011 Rentschler S, Harris BS, Kuznekoff L, Jain R, Manderfield L, Lu MM, Morley GE, Patel VV, Epstein JA. Notch signaling regulates murine atrioventricular conduction and the formation of accessory pathways. The Journal of Clinical Investigation. 121: 525-33. PMID 21266778 DOI: 10.1172/Jci44470  0.399
2011 Rentschler S, Epstein JA. Kicking the epicardium up a notch. Circulation Research. 108: 6-8. PMID 21212389 DOI: 10.1161/Circresaha.110.237297  0.45
2011 Trivedi CM, Epstein JA. Heart-healthy hypertrophy. Cell Metabolism. 13: 3-4. PMID 21195341 DOI: 10.1016/J.Cmet.2010.12.012  0.366
2011 Jain R, Engleka KA, Rentschler SL, Manderfield LJ, Li L, Yuan L, Epstein JA. Cardiac neural crest orchestrates remodeling and functional maturation of mouse semilunar valves. The Journal of Clinical Investigation. 121: 422-30. PMID 21157040 DOI: 10.1172/Jci44244  0.342
2010 LeBoeuf M, Terrell A, Trivedi S, Sinha S, Epstein JA, Olson EN, Morrisey EE, Millar SE. Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells. Developmental Cell. 19: 807-18. PMID 21093383 DOI: 10.1016/J.Devcel.2010.10.015  0.335
2010 Albrecht I, Niesner U, Janke M, Menning A, Loddenkemper C, Kühl AA, Lepenies I, Lexberg MH, Westendorf K, Hradilkova K, Grün J, Hamann A, Epstein JA, Chang HD, Tokoyoda K, et al. Persistence of effector memory Th1 cells is regulated by Hopx. European Journal of Immunology. 40: 2993-3006. PMID 21061432 DOI: 10.1002/Eji.201040936  0.317
2010 Epstein JA. Franklin H. Epstein Lecture. Cardiac development and implications for heart disease. The New England Journal of Medicine. 363: 1638-47. PMID 20961247 DOI: 10.1056/Nejmra1003941  0.361
2010 Lee JS, Padmanabhan A, Shin J, Zhu S, Guo F, Kanki JP, Epstein JA, Look AT. Oligodendrocyte progenitor cell numbers and migration are regulated by the zebrafish orthologs of the NF1 tumor suppressor gene. Human Molecular Genetics. 19: 4643-53. PMID 20858602 DOI: 10.1093/Hmg/Ddq395  0.595
2010 Trivedi CM, Zhu W, Wang Q, Jia C, Kee HJ, Li L, Hannenhalli S, Epstein JA. Hopx and Hdac2 interact to modulate Gata4 acetylation and embryonic cardiac myocyte proliferation. Developmental Cell. 19: 450-9. PMID 20833366 DOI: 10.1016/J.Devcel.2010.08.012  0.565
2010 Stoller JZ, Huang L, Tan CC, Huang F, Zhou DD, Yang J, Gelb BD, Epstein JA. Ash2l interacts with Tbx1 and is required during early embryogenesis. Experimental Biology and Medicine (Maywood, N.J.). 235: 569-76. PMID 20463296 DOI: 10.1258/Ebm.2010.009318  0.375
2010 Jain R, Rentschler S, Epstein JA. Notch and cardiac outflow tract development. Annals of the New York Academy of Sciences. 1188: 184-90. PMID 20201902 DOI: 10.1111/J.1749-6632.2009.05099.X  0.439
2010 Degenhardt K, Wright AC, Horng D, Padmanabhan A, Epstein JA. Rapid 3D phenotyping of cardiovascular development in mouse embryos by micro-CT with iodine staining. Circulation. Cardiovascular Imaging. 3: 314-22. PMID 20190279 DOI: 10.1161/Circimaging.109.918482  0.588
2010 Chokas AL, Trivedi CM, Lu MM, Tucker PW, Li S, Epstein JA, Morrisey EE. Foxp1/2/4-NuRD interactions regulate gene expression and epithelial injury response in the lung via regulation of interleukin-6. The Journal of Biological Chemistry. 285: 13304-13. PMID 20185820 DOI: 10.1074/Jbc.M109.088468  0.344
2010 Degenhardt KR, Milewski RC, Padmanabhan A, Miller M, Singh MK, Lang D, Engleka KA, Wu M, Li J, Zhou D, Antonucci N, Li L, Epstein JA. Distinct enhancers at the Pax3 locus can function redundantly to regulate neural tube and neural crest expressions. Developmental Biology. 339: 519-27. PMID 20045680 DOI: 10.1016/J.Ydbio.2009.12.030  0.792
2010 Rentschler S, Jain R, Epstein JA. Tissue-tissue interactions during morphogenesis of the outflow tract. Pediatric Cardiology. 31: 408-13. PMID 20039033 DOI: 10.1007/S00246-009-9611-2  0.42
2010 Singh MK, Li Y, Li S, Cobb RM, Zhou D, Lu MM, Epstein JA, Morrisey EE, Gruber PJ. Gata4 and Gata5 cooperatively regulate cardiac myocyte proliferation in mice. The Journal of Biological Chemistry. 285: 1765-72. PMID 19889636 DOI: 10.1074/Jbc.M109.038539  0.461
2009 Padmanabhan A, Lee JS, Ismat FA, Lu MM, Lawson ND, Kanki JP, Look AT, Epstein JA. Cardiac and vascular functions of the zebrafish orthologues of the type I neurofibromatosis gene NFI. Proceedings of the National Academy of Sciences of the United States of America. 106: 22305-10. PMID 19966217 DOI: 10.1073/Pnas.0901932106  0.645
2009 Zhu W, Trivedi CM, Zhou D, Yuan L, Lu MM, Epstein JA. Inpp5f is a polyphosphoinositide phosphatase that regulates cardiac hypertrophic responsiveness. Circulation Research. 105: 1240-7. PMID 19875726 DOI: 10.1161/Circresaha.109.208785  0.565
2009 Levin MD, Lu MM, Petrenko NB, Hawkins BJ, Gupta TH, Lang D, Buckley PT, Jochems J, Liu F, Spurney CF, Yuan LJ, Jacobson JT, Brown CB, Huang L, Beermann F, ... ... Epstein JA, et al. Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers. The Journal of Clinical Investigation. 119: 3420-36. PMID 19855129 DOI: 10.1172/Jci39109  0.403
2009 Xu J, Ismat FA, Wang T, Lu MM, Antonucci N, Epstein JA. Cardiomyocyte-specific loss of neurofibromin promotes cardiac hypertrophy and dysfunction. Circulation Research. 105: 304-11. PMID 19574548 DOI: 10.1161/Circresaha.109.201509  0.387
2009 High FA, Jain R, Stoller JZ, Antonucci NB, Lu MM, Loomes KM, Kaestner KH, Pear WS, Epstein JA. Murine Jagged1/Notch signaling in the second heart field orchestrates Fgf8 expression and tissue-tissue interactions during outflow tract development. The Journal of Clinical Investigation. 119: 1986-96. PMID 19509466 DOI: 10.1172/Jci38922  0.747
2009 Aziz A, Miyake T, Engleka KA, Epstein JA, McDermott JC. Menin expression modulates mesenchymal cell commitment to the myogenic and osteogenic lineages. Developmental Biology. 332: 116-30. PMID 19464283 DOI: 10.1016/J.Ydbio.2009.05.555  0.391
2009 Nishijo K, Hosoyama T, Bjornson CR, Schaffer BS, Prajapati SI, Bahadur AN, Hansen MS, Blandford MC, McCleish AT, Rubin BP, Epstein JA, Rando TA, Capecchi MR, Keller C. Biomarker system for studying muscle, stem cells, and cancer in vivo. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 2681-90. PMID 19332644 DOI: 10.1096/Fj.08-128116  0.352
2009 Griffith AV, Cardenas K, Carter C, Gordon J, Iberg A, Engleka K, Epstein JA, Manley NR, Richie ER. Increased thymus- and decreased parathyroid-fated organ domains in Splotch mutant embryos. Developmental Biology. 327: 216-27. PMID 19135046 DOI: 10.1016/J.Ydbio.2008.12.019  0.344
2009 Zhang Y, Singh MK, Degenhardt KR, Lu MM, Bennett J, Yoshida Y, Epstein JA. Tie2Cre-mediated inactivation of plexinD1 results in congenital heart, vascular and skeletal defects. Developmental Biology. 325: 82-93. PMID 18992737 DOI: 10.1016/J.Ydbio.2008.09.031  0.453
2008 Choi YI, Duke-Cohan JS, Ahmed WB, Handley MA, Mann F, Epstein JA, Clayton LK, Reinherz EL. PlexinD1 glycoprotein controls migration of positively selected thymocytes into the medulla. Immunity. 29: 888-98. PMID 19027330 DOI: 10.1016/J.Immuni.2008.10.008  0.3
2008 Liu F, Levin MD, Petrenko NB, Lu MM, Wang T, Yuan LJ, Stout AL, Epstein JA, Patel VV. Histone-deacetylase inhibition reverses atrial arrhythmia inducibility and fibrosis in cardiac hypertrophy independent of angiotensin. Journal of Molecular and Cellular Cardiology. 45: 715-23. PMID 18926829 DOI: 10.1016/J.Yjmcc.2008.08.015  0.339
2008 Kerkela R, Kockeritz L, Macaulay K, Zhou J, Doble BW, Beahm C, Greytak S, Woulfe K, Trivedi CM, Woodgett JR, Epstein JA, Force T, Huggins GS. Deletion of GSK-3beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation. The Journal of Clinical Investigation. 118: 3609-18. PMID 18830417 DOI: 10.1172/Jci36245  0.385
2008 Trivedi CM, Lu MM, Wang Q, Epstein JA. Transgenic overexpression of Hdac3 in the heart produces increased postnatal cardiac myocyte proliferation but does not induce hypertrophy. The Journal of Biological Chemistry. 283: 26484-9. PMID 18625706 DOI: 10.1074/Jbc.M803686200  0.395
2008 Granger A, Abdullah I, Huebner F, Stout A, Wang T, Huebner T, Epstein JA, Gruber PJ. Histone deacetylase inhibition reduces myocardial ischemia-reperfusion injury in mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 3549-60. PMID 18606865 DOI: 10.1096/Fj.08-108548  0.304
2008 Lagha M, Kormish JD, Rocancourt D, Manceau M, Epstein JA, Zaret KS, Relaix F, Buckingham ME. Pax3 regulation of FGF signaling affects the progression of embryonic progenitor cells into the myogenic program. Genes & Development. 22: 1828-37. PMID 18593883 DOI: 10.1101/Gad.477908  0.435
2008 De Toni A, Zbinden M, Epstein JA, Ruiz i Altaba A, Prochiantz A, Caillé I. Regulation of survival in adult hippocampal and glioblastoma stem cell lineages by the homeodomain-only protein HOP. Neural Development. 3: 13. PMID 18507846 DOI: 10.1186/1749-8104-3-13  0.328
2008 Tan CC, Sindhu KV, Li S, Nishio H, Stoller JZ, Oishi K, Puttreddy S, Lee TJ, Epstein JA, Walsh MJ, Gelb BD. Transcription factor Ap2delta associates with Ash2l and ALR, a trithorax family histone methyltransferase, to activate Hoxc8 transcription. Proceedings of the National Academy of Sciences of the United States of America. 105: 7472-7. PMID 18495928 DOI: 10.1073/Pnas.0711896105  0.317
2008 Wu M, Li J, Engleka KA, Zhou B, Lu MM, Plotkin JB, Epstein JA. Persistent expression of Pax3 in the neural crest causes cleft palate and defective osteogenesis in mice. The Journal of Clinical Investigation. 118: 2076-87. PMID 18483623 DOI: 10.1172/Jci33715  0.449
2008 Stoller JZ, Degenhardt KR, Huang L, Zhou DD, Lu MM, Epstein JA. Cre reporter mouse expressing a nuclear localized fusion of GFP and beta-galactosidase reveals new derivatives of Pax3-expressing precursors. Genesis (New York, N.Y. : 2000). 46: 200-4. PMID 18395835 DOI: 10.1002/Dvg.20384  0.342
2008 Epstein JA. Currying favor for the heart. The Journal of Clinical Investigation. 118: 850-2. PMID 18292806 DOI: 10.1172/Jci34650  0.358
2008 High FA, Lu MM, Pear WS, Loomes KM, Kaestner KH, Epstein JA. Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development. Proceedings of the National Academy of Sciences of the United States of America. 105: 1955-9. PMID 18245384 DOI: 10.1073/Pnas.0709663105  0.716
2008 Hori K, Cholewa-Waclaw J, Nakada Y, Glasgow SM, Masui T, Henke RM, Wildner H, Martarelli B, Beres TM, Epstein JA, Magnuson MA, Macdonald RJ, Birchmeier C, Johnson JE. A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling. Genes & Development. 22: 166-78. PMID 18198335 DOI: 10.1101/Gad.1628008  0.358
2008 Huang J, Cheng L, Li J, Chen M, Zhou D, Lu MM, Proweller A, Epstein JA, Parmacek MS. Myocardin regulates expression of contractile genes in smooth muscle cells and is required for closure of the ductus arteriosus in mice. The Journal of Clinical Investigation. 118: 515-25. PMID 18188448 DOI: 10.1172/Jci33304  0.391
2008 High FA, Epstein JA. The multifaceted role of Notch in cardiac development and disease. Nature Reviews. Genetics. 9: 49-61. PMID 18071321 DOI: 10.1038/Nrg2279  0.745
2008 Zhang Y, Yoshida Y, Lu M, Epstein JA. Endothelial deletion of PlexinD1 results in congenital heart, vascular and skeletal defects Developmental Biology. 319: 604. DOI: 10.1016/J.Ydbio.2008.05.444  0.333
2008 Xu J, Ismat FA, Wang T, Lu MM, Epstein JA. Cardiomyocyte-specific loss of neurofibromin promotes cardiac hypertrophy and dysfunction through activation of the fetal gene program Developmental Biology. 319: 525. DOI: 10.1016/J.Ydbio.2008.05.212  0.357
2008 Wu M, Li J, Engleka KA, Zhou B, Lu M, Plotkin J, Epstein JA. Persistent expression of Pax3 in neural crest causes cleft palate and defective osteogenesis Developmental Biology. 319: 500-501. DOI: 10.1016/J.Ydbio.2008.05.120  0.365
2007 High F, Epstein JA. Signalling pathways regulating cardiac neural crest migration and differentiation. Novartis Foundation Symposium. 283: 152-61; discussion 1. PMID 18300420 DOI: 10.1002/9780470319413.Ch12  0.745
2007 Xu J, Ismat FA, Wang T, Yang J, Epstein JA. NF1 regulates a Ras-dependent vascular smooth muscle proliferative injury response. Circulation. 116: 2148-56. PMID 17967772 DOI: 10.1161/Circulationaha.107.707752  0.365
2007 Engleka KA, Wu M, Zhang M, Antonucci NB, Epstein JA. Menin is required in cranial neural crest for palatogenesis and perinatal viability. Developmental Biology. 311: 524-37. PMID 17927973 DOI: 10.1016/J.Ydbio.2007.08.057  0.437
2007 Vasyutina E, Lenhard DC, Wende H, Erdmann B, Epstein JA, Birchmeier C. RBP-J (Rbpsuh) is essential to maintain muscle progenitor cells and to generate satellite cells. Proceedings of the National Academy of Sciences of the United States of America. 104: 4443-8. PMID 17360543 DOI: 10.1073/Pnas.0610647104  0.364
2007 Trivedi CM, Luo Y, Yin Z, Zhang M, Zhu W, Wang T, Floss T, Goettlicher M, Noppinger PR, Wurst W, Ferrari VA, Abrams CS, Gruber PJ, Epstein JA. Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity. Nature Medicine. 13: 324-31. PMID 17322895 DOI: 10.1038/Nm1552  0.567
2007 High FA, Zhang M, Proweller A, Tu L, Parmacek MS, Pear WS, Epstein JA. An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation. The Journal of Clinical Investigation. 117: 353-63. PMID 17273555 DOI: 10.1172/Jci30070  0.77
2006 Luo Y, High FA, Epstein JA, Radice GL. N-cadherin is required for neural crest remodeling of the cardiac outflow tract. Developmental Biology. 299: 517-28. PMID 17014840 DOI: 10.1016/J.Ydbio.2006.09.003  0.736
2006 Hannenhalli S, Putt ME, Gilmore JM, Wang J, Parmacek MS, Epstein JA, Morrisey EE, Margulies KB, Cappola TP. Transcriptional genomics associates FOX transcription factors with human heart failure. Circulation. 114: 1269-76. PMID 16952980 DOI: 10.1161/Circulationaha.106.632430  0.366
2006 Kook H, Yung WW, Simpson RJ, Kee HJ, Shin S, Lowry JA, Loughlin FE, Yin Z, Epstein JA, Mackay JP. Analysis of the structure and function of the transcriptional coregulator HOP. Biochemistry. 45: 10584-90. PMID 16939210 DOI: 10.1021/Bi060641S  0.33
2006 Ismat FA, Xu J, Lu MM, Epstein JA. The neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1 mice. The Journal of Clinical Investigation. 116: 2378-84. PMID 16906226 DOI: 10.1172/Jci28341  0.375
2006 Liu S, Liu F, Schneider AE, St Amand T, Epstein JA, Gutstein DE. Distinct cardiac malformations caused by absence of connexin 43 in the neural crest and in the non-crest neural tube. Development (Cambridge, England). 133: 2063-73. PMID 16624854 DOI: 10.1242/Dev.02374  0.451
2006 Nowotschin S, Liao J, Gage PJ, Epstein JA, Campione M, Morrow BE. Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field. Development (Cambridge, England). 133: 1565-73. PMID 16556915 DOI: 10.1242/Dev.02309  0.432
2006 Yin Z, Gonzales L, Kolla V, Rath N, Zhang Y, Lu MM, Kimura S, Ballard PL, Beers MF, Epstein JA, Morrisey EE. Hop functions downstream of Nkx2.1 and GATA6 to mediate HDAC-dependent negative regulation of pulmonary gene expression. American Journal of Physiology. Lung Cellular and Molecular Physiology. 291: L191-9. PMID 16510470 DOI: 10.1152/Ajplung.00385.2005  0.407
2006 St Amand TR, Lu JT, Zamora M, Gu Y, Stricker J, Hoshijima M, Epstein JA, Ross JJ, Ruiz-Lozano P, Chien KR. Distinct roles of HF-1b/Sp4 in ventricular and neural crest cells lineages affect cardiac conduction system development. Developmental Biology. 291: 208-17. PMID 16430881 DOI: 10.1016/J.Ydbio.2005.10.018  0.42
2006 Schienda J, Engleka KA, Jun S, Hansen MS, Epstein JA, Tabin CJ, Kunkel LM, Kardon G. Somitic origin of limb muscle satellite and side population cells. Proceedings of the National Academy of Sciences of the United States of America. 103: 945-50. PMID 16418263 DOI: 10.1073/Pnas.0510164103  0.342
2006 Kee HJ, Sohn IS, Nam KI, Park JE, Qian YR, Yin Z, Ahn Y, Jeong MH, Bang YJ, Kim N, Kim JK, Kim KK, Epstein JA, Kook H. Inhibition of histone deacetylation blocks cardiac hypertrophy induced by angiotensin II infusion and aortic banding. Circulation. 113: 51-9. PMID 16380549 DOI: 10.1161/Circulationaha.105.559724  0.316
2006 Maillard I, High F, Shestova O, Dedhia P, Epstein JA, Pear WS. Notch Signaling Regulates Hematopoietic Stem Cell Homeostasis in the Fetal Liver through a Non-Cell-Autonomous Mechanism. Blood. 108: 440-440. DOI: 10.1182/Blood.V108.11.440.440  0.73
2005 Wynder C, Hakimi MA, Epstein JA, Shilatifard A, Shiekhattar R. Recruitment of MLL by HMG-domain protein iBRAF promotes neural differentiation. Nature Cell Biology. 7: 1113-7. PMID 16227968 DOI: 10.1038/Ncb1312  0.325
2005 Wang J, Sridurongrit S, Dudas M, Thomas P, Nagy A, Schneider MD, Epstein JA, Kaartinen V. Atrioventricular cushion transformation is mediated by ALK2 in the developing mouse heart. Developmental Biology. 286: 299-310. PMID 16140292 DOI: 10.1016/J.Ydbio.2005.07.035  0.43
2005 Ackerman KG, Herron BJ, Vargas SO, Huang H, Tevosian SG, Kochilas L, Rao C, Pober BR, Babiuk RP, Epstein JA, Greer JJ, Beier DR. Fog2 is required for normal diaphragm and lung development in mice and humans. Plos Genetics. 1: 58-65. PMID 16103912 DOI: 10.1371/Journal.Pgen.0010010  0.338
2005 Stoller JZ, Epstein JA. Cardiac neural crest. Seminars in Cell & Developmental Biology. 16: 704-15. PMID 16054405 DOI: 10.1016/J.Semcdb.2005.06.004  0.451
2005 Epstein JA, Parmacek MS. Recent advances in cardiac development with therapeutic implications for adult cardiovascular disease. Circulation. 112: 592-7. PMID 16043659 DOI: 10.1161/Circulationaha.104.479857  0.414
2005 Briegel KJ, Baldwin HS, Epstein JA, Joyner AL. Congenital heart disease reminiscent of partial trisomy 2p syndrome in mice transgenic for the transcription factor Lbh. Development (Cambridge, England). 132: 3305-16. PMID 15958514 DOI: 10.1242/Dev.01887  0.453
2005 Li J, Zhu X, Chen M, Cheng L, Zhou D, Lu MM, Du K, Epstein JA, Parmacek MS. Myocardin-related transcription factor B is required in cardiac neural crest for smooth muscle differentiation and cardiovascular development. Proceedings of the National Academy of Sciences of the United States of America. 102: 8916-21. PMID 15951419 DOI: 10.1073/Pnas.0503741102  0.443
2005 Engleka KA, Gitler AD, Zhang M, Zhou DD, High FA, Epstein JA. Insertion of Cre into the Pax3 locus creates a new allele of Splotch and identifies unexpected Pax3 derivatives. Developmental Biology. 280: 396-406. PMID 15882581 DOI: 10.1016/J.Ydbio.2005.02.002  0.788
2005 Abdullah I, Lepore JJ, Epstein JA, Parmacek MS, Gruber PJ. MRL mice fail to heal the heart in response to ischemia-reperfusion injury. Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. 13: 205-8. PMID 15828946 DOI: 10.1111/J.1067-1927.2005.130212.X  0.316
2005 Ismat FA, Zhang M, Kook H, Huang B, Zhou R, Ferrari VA, Epstein JA, Patel VV. Homeobox protein Hop functions in the adult cardiac conduction system. Circulation Research. 96: 898-903. PMID 15790958 DOI: 10.1161/01.Res.0000163108.47258.F3  0.401
2005 Brown CB, Engleka KA, Wenning J, Min Lu M, Epstein JA. Identification of a hypaxial somite enhancer element regulating Pax3 expression in migrating myoblasts and characterization of hypaxial muscle Cre transgenic mice. Genesis (New York, N.Y. : 2000). 41: 202-9. PMID 15789408 DOI: 10.1002/Gene.20116  0.4
2005 Lang D, Lu MM, Huang L, Engleka KA, Zhang M, Chu EY, Lipner S, Skoultchi A, Millar SE, Epstein JA. Pax3 functions at a nodal point in melanocyte stem cell differentiation. Nature. 433: 884-7. PMID 15729346 DOI: 10.1038/Nature03292  0.369
2005 Parmacek MS, Epstein JA. Pursuing cardiac progenitors: regeneration redux. Cell. 120: 295-8. PMID 15707888 DOI: 10.1016/J.Cell.2005.01.025  0.406
2005 Stoller JZ, Epstein JA. Identification of a novel nuclear localization signal in Tbx1 that is deleted in DiGeorge syndrome patients harboring the 1223delC mutation. Human Molecular Genetics. 14: 885-92. PMID 15703190 DOI: 10.1093/Hmg/Ddi081  0.31
2004 Horwitz PA, Tsai EJ, Putt ME, Gilmore JM, Lepore JJ, Parmacek MS, Kao AC, Desai SS, Goldberg LR, Brozena SC, Jessup ML, Epstein JA, Cappola TP. Detection of cardiac allograft rejection and response to immunosuppressive therapy with peripheral blood gene expression. Circulation. 110: 3815-21. PMID 15583081 DOI: 10.1161/01.Cir.0000150539.72783.Bf  0.308
2004 Araki T, Mohi MG, Ismat FA, Bronson RT, Williams IR, Kutok JL, Yang W, Pao LI, Gilliland DG, Epstein JA, Neel BG. Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation. Nature Medicine. 10: 849-57. PMID 15273746 DOI: 10.1038/Nm1084  0.381
2004 Torres-Vázquez J, Gitler AD, Fraser SD, Berk JD, Van N Pham, Fishman MC, Childs S, Epstein JA, Weinstein BM. Semaphorin-plexin signaling guides patterning of the developing vasculature. Developmental Cell. 7: 117-23. PMID 15239959 DOI: 10.1016/J.Devcel.2004.06.008  0.573
2004 Gitler AD, Lu MM, Epstein JA. PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development. Developmental Cell. 7: 107-16. PMID 15239958 DOI: 10.1016/J.Devcel.2004.06.002  0.644
2004 Kaartinen V, Dudas M, Nagy A, Sridurongrit S, Lu MM, Epstein JA. Cardiac outflow tract defects in mice lacking ALK2 in neural crest cells. Development (Cambridge, England). 131: 3481-90. PMID 15226263 DOI: 10.1242/Dev.01214  0.49
2004 Liao J, Kochilas L, Nowotschin S, Arnold JS, Aggarwal VS, Epstein JA, Brown MC, Adams J, Morrow BE. Full spectrum of malformations in velo-cardio-facial syndrome/DiGeorge syndrome mouse models by altering Tbx1 dosage. Human Molecular Genetics. 13: 1577-85. PMID 15190012 DOI: 10.1093/Hmg/Ddh176  0.349
2004 Akiyama H, Chaboissier MC, Behringer RR, Rowitch DH, Schedl A, Epstein JA, De Crombrugghe B. Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa Proceedings of the National Academy of Sciences of the United States of America. 101: 6502-6507. PMID 15096597 DOI: 10.1073/Pnas.0401711101  0.421
2004 Chang CP, McDill BW, Neilson JR, Joist HE, Epstein JA, Crabtree GR, Chen F. Calcineurin is required in urinary tract mesenchyme for the development of the pyeloureteral peristaltic machinery. The Journal of Clinical Investigation. 113: 1051-8. PMID 15057312 DOI: 10.1172/Jci20049  0.335
2004 Gruber PJ, Epstein JA. Development gone awry: congenital heart disease. Circulation Research. 94: 273-83. PMID 14976138 DOI: 10.1161/01.Res.0000116144.43797.3B  0.334
2004 Brown CB, Wenning JM, Lu MM, Epstein DJ, Meyers EN, Epstein JA. Cre-mediated excision of Fgf8 in the Tbx1 expression domain reveals a critical role for Fgf8 in cardiovascular development in the mouse. Developmental Biology. 267: 190-202. PMID 14975726 DOI: 10.1016/J.Ydbio.2003.10.024  0.446
2004 Gitler AD, Kong Y, Choi JK, Zhu Y, Pear WS, Epstein JA. Tie2-Cre-induced inactivation of a conditional mutant Nf1 allele in mouse results in a myeloproliferative disorder that models juvenile myelomonocytic leukemia. Pediatric Research. 55: 581-4. PMID 14739366 DOI: 10.1203/01.Pdr.0000113462.98851.2E  0.622
2004 Milewski RC, Chi NC, Li J, Brown C, Lu MM, Epstein JA. Identification of minimal enhancer elements sufficient for Pax3 expression in neural crest and implication of Tead2 as a regulator of Pax3. Development (Cambridge, England). 131: 829-37. PMID 14736747 DOI: 10.1242/Dev.00975  0.796
2004 Kook H, Epstein JA. Hopping to the beat. Hop regulation of cardiac gene expression. Trends in Cardiovascular Medicine. 13: 261-4. PMID 14522464 DOI: 10.1016/S1050-1738(03)00107-5  0.439
2004 Lang D, Epstein JA. Sox10 and Pax3 physically interact to mediate activation of a conserved c-RET enhancer. Human Molecular Genetics. 12: 937-45. PMID 12668617 DOI: 10.1093/Hmg/Ddg107  0.38
2004 Brown CB, Wenning JM, Lu MM, Epstein DJ, Meyers EN, Epstein JA. Corrigendum to “Cre-mediated excision of Fgf8 in the Tbx1 expression domain reveals a critical role for Fgf8 in cardiovascular development in the mouse” [Dev. Biol. 267 (2004) 190–202] Developmental Biology. 271: 223. DOI: 10.1016/J.Ydbio.2004.04.002  0.32
2003 Gitler AD, Lu MM, Jiang YQ, Epstein JA, Gruber PJ. Molecular markers of cardiac endocardial cushion development. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 228: 643-50. PMID 14648841 DOI: 10.1002/Dvdy.10418  0.663
2003 Epstein JA, Neel BG. An eye on organ development Nature. 426: 238-239. PMID 14628032 DOI: 10.1038/426238A  0.329
2003 Katz SG, Williams A, Yang J, Fujiwara Y, Tsang AP, Epstein JA, Orkin SH. Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development. Proceedings of the National Academy of Sciences of the United States of America. 100: 14030-5. PMID 14614148 DOI: 10.1073/Pnas.1936250100  0.48
2003 Lang D, Brown CB, Milewski R, Jiang YQ, Lu MM, Epstein JA. Distinct enhancers regulate neural expression of Pax7 Genomics. 82: 553-560. PMID 14559212 DOI: 10.1016/S0888-7543(03)00178-2  0.782
2003 Kook H, Lepore JJ, Gitler AD, Lu MM, Wing-Man Yung W, Mackay J, Zhou R, Ferrari V, Gruber P, Epstein JA. Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop. The Journal of Clinical Investigation. 112: 863-71. PMID 12975471 DOI: 10.1172/Jci19137  0.639
2003 Gitler AD, Epstein JA. Regulating heart development: the role of Nf1. Cell Cycle (Georgetown, Tex.). 2: 96-8. PMID 12695655 DOI: 10.4161/Cc.2.2.299  0.641
2003 Gitler AD, Zhu Y, Ismat FA, Lu MM, Yamauchi Y, Parada LF, Epstein JA. Nf1 has an essential role in endothelial cells. Nature Genetics. 33: 75-9. PMID 12469121 DOI: 10.1038/Ng1059  0.655
2002 Gitler AD, Brown CB, Kochilas L, Li J, Epstein JA. Neural crest migration and mouse models of congenital heart disease. Cold Spring Harbor Symposia On Quantitative Biology. 67: 57-62. PMID 12858524 DOI: 10.1101/Sqb.2002.67.57  0.617
2002 Kochilas L, Merscher-Gomez S, Lu MM, Potluri V, Liao J, Kucherlapati R, Morrow B, Epstein JA. The role of neural crest during cardiac development in a mouse model of DiGeorge syndrome. Developmental Biology. 251: 157-66. PMID 12413905 DOI: 10.1006/Dbio.2002.0819  0.475
2002 Chen F, Kook H, Milewski R, Gitler AD, Lu MM, Li J, Nazarian R, Schnepp R, Jen K, Biben C, Runke G, Mackay JP, Novotny J, Schwartz RJ, Harvey RP, ... ... Epstein JA, et al. Hop is an unusual homeobox gene that modulates cardiac development. Cell. 110: 713-23. PMID 12297045 DOI: 10.1016/S0092-8674(02)00932-7  0.8
2002 Glaser R, Lu MM, Narula N, Epstein JA. Smooth muscle cells, but not myocytes, of host origin in transplanted human hearts. Circulation. 106: 17-9. PMID 12093763 DOI: 10.1161/01.Cir.0000021923.58307.8F  0.341
2002 Epstein JA, Rader DJ, S.parmacek M. Perspective: Cardiovascular disease in the postgenomic era - Lessons learned and challenges ahead Endocrinology. 143: 2045-2050. PMID 12021168 DOI: 10.1210/Endo.143.6.8910  0.337
2002 Chi N, Epstein JA. Getting your Pax straight: Pax proteins in development and disease. Trends in Genetics : Tig. 18: 41-7. PMID 11750700 DOI: 10.1016/S0168-9525(01)02594-X  0.408
2001 Kudoh T, Tsang M, Hukriede NA, Chen X, Dedekian M, Clarke CJ, Kiang A, Schultz S, Epstein JA, Toyama R, Dawid IB. A gene expression screen in zebrafish embryogenesis. Genome Research. 11: 1979-87. PMID 11731487 DOI: 10.1101/Gr.209601  0.311
2001 Funke B, Epstein JA, Kochilas LK, Lu MM, Pandita RK, Liao J, Bauerndistel R, Schüler T, Schorle H, Brown MC, Adams J, Morrow BE. Mice overexpressing genes from the 22q11 region deleted in velo-cardio-facial syndrome/DiGeorge syndrome have middle and inner ear defects Human Molecular Genetics. 10: 2549-2556. PMID 11709542 DOI: 10.1093/Hmg/10.22.2549  0.331
2001 Epstein JA. Developing models of DiGeorge syndrome. Trends in Genetics : Tig. 17: S13-7. PMID 11585671 DOI: 10.1016/S0168-9525(01)02450-7  0.354
2001 Chen F, Collin GB, Liu KC, Beier DR, Eccles M, Nishina PM, Moshang T, Epstein JA. Characterization of the murine Lbx2 promoter, identification of the human homologue, and evaluation as a candidate for Alström syndrome. Genomics. 74: 219-27. PMID 11386758 DOI: 10.1006/Geno.2001.6539  0.349
2001 Merscher S, Funke B, Epstein JA, Heyer J, Puech A, Lu MM, Xavier RJ, Demay MB, Russell RG, Factor S, Tokooya K, Jore BS, Lopez M, Pandita RK, Lia M, et al. TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome. Cell. 104: 619-29. PMID 11239417 DOI: 10.1016/S0092-8674(01)00247-1  0.346
2001 Marmorstein LY, Kinev AV, Chan GKT, Bochar DA, Beniya H, Epstein JA, Yen TJ, Shiekhattar R. A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression Cell. 104: 247-257. PMID 11207365 DOI: 10.1016/S0092-8674(01)00209-4  0.313
2001 Loftin CD, Trivedi DB, Tiano HF, Clark JA, Lee CA, Epstein JA, Morham SG, Breyer MD, Nguyen M, Hawkins BM, Goulet JL, Smithies O, Koller BH, Langenbach R. Failure of ductus arteriosus closure and remodeling in neonatal mice deficient in cyclooxygenase-1 and cyclooxygenase-2. Proceedings of the National Academy of Sciences of the United States of America. 98: 1059-64. PMID 11158594 DOI: 10.1073/Pnas.98.3.1059  0.324
2000 Lu MM, Chen F, Gitler A, Li J, Jin F, Ma XK, Epstein JA. Cloning and expression analysis of murine lupin, a member of a novel gene family that is conserved through evolution and associated with Lupus inclusions Development Genes and Evolution. 210: 512-517. PMID 11180800 DOI: 10.1007/S004270000093  0.615
2000 Epstein JA, Buck CA. Transcriptional regulation of cardiac development: implications for congenital heart disease and DiGeorge syndrome. Pediatric Research. 48: 717-24. PMID 11102536 DOI: 10.1203/00006450-200012000-00003  0.397
2000 Epstein JA. Developmental cardiology comes of age. Circulation Research. 87: 833-4. PMID 11073875 DOI: 10.1161/01.Res.87.10.833  0.439
2000 Lang D, Chen F, Milewski R, Li J, Lu MM, Epstein JA. Pax3 is required for enteric ganglia formation and functions with Sox10 to modulate expression of c-ret Journal of Clinical Investigation. 106: 963-971. PMID 11032856 DOI: 10.1172/Jci10828  0.766
2000 Epstein JA. Pax3 and vertebrate development Methods in Molecular Biology (Clifton, N.J.). 137: 459-470. PMID 10948560 DOI: 10.1385/1-59259-066-7:459  0.31
2000 Galili N, Nayak S, Epstein JA, Buck CA. Rnf4, a RING protein expressed in the developing nervous and reproductive systems, interacts with Gscl, a gene within the DiGeorge critical region. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 218: 102-11. PMID 10822263 DOI: 10.1002/(Sici)1097-0177(200005)218:1<102::Aid-Dvdy9>3.0.Co;2-A  0.375
2000 Li J, Chen F, Epstein JA. Neural crest expression of Cre recombinase directed by the proximal Pax3 promoter in transgenic mice. Genesis (New York, N.Y. : 2000). 26: 162-4. PMID 10686619 DOI: 10.1002/(Sici)1526-968X(200002)26:2<162::Aid-Gene21>3.0.Co;2-R  0.362
1999 Chen F, Liu KC, Epstein JA. Lbx2, a novel murine homeobox gene related to the Drosophila ladybird genes is expressed in the developing urogenital system, eye and brain. Mechanisms of Development. 84: 181-184. PMID 10473138 DOI: 10.1016/S0925-4773(99)00073-8  0.339
1999 Lakkis MM, Golden JA, O'Shea KS, Epstein JA. Neurofibromin deficiency in mice causes exencephaly and is a modifier for Splotch neural tube defects. Developmental Biology. 212: 80-92. PMID 10419687 DOI: 10.1006/Dbio.1999.9327  0.413
1999 Kochilas LK, Li J, Jin F, Buck CA, Epstein JA. p57Kip2 expression is enhanced during mid-cardiac murine development and is restricted to trabecular myocardium. Pediatric Research. 45: 635-42. PMID 10231856 DOI: 10.1203/00006450-199905010-00004  0.473
1998 Epstein JA, Song B, Lakkis M, Wang C. Tumor-specific PAX3-FKHR transcription factor, but not PAX3, activates the platelet-derived growth factor alpha receptor. Molecular and Cellular Biology. 18: 4118-30. PMID 9632796 DOI: 10.1128/Mcb.18.7.4118  0.322
1998 Galili N, Epstein JA, Leconte I, Nayak S, Buck CA. Gscl, a gene within the minimal DiGeorge critical region, is expressed in primordial germ cells and the developing pons. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 212: 86-93. PMID 9603426 DOI: 10.1002/(Sici)1097-0177(199805)212:1<86::Aid-Aja8>3.0.Co;2-Z  0.371
1998 St John Sutton M, Epstein JA. Hypertrophic cardiomyopathy--beyond the sarcomere. The New England Journal of Medicine. 338: 1303-4. PMID 9562586 DOI: 10.1056/Nejm199804303381810  0.362
1998 Kochilas LK, Buck CA, Epstein JA. Identification of Genes involved in Cardiac Development • 120 Pediatric Research. 43: 23-23. DOI: 10.1203/00006450-199804001-00141  0.41
1997 Xu PX, Cheng J, Epstein JA, Maas RL. Mouse Eya genes are expressed during limb tendon development and encode a transcriptional activation function. Proceedings of the National Academy of Sciences of the United States of America. 94: 11974-9. PMID 9342347 DOI: 10.1073/Pnas.94.22.11974  0.394
1996 Epstein JA, Shapiro DN, Cheng J, Lam PY, Maas RL. Pax3 modulates expression of the c-Met receptor during limb muscle development. Proceedings of the National Academy of Sciences of the United States of America. 93: 4213-8. PMID 8633043 DOI: 10.1073/Pnas.93.9.4213  0.368
1995 Epstein JA, Lam P, Jepeal L, Maas RL, Shapiro DN. Pax3 inhibits myogenic differentiation of cultured myoblast cells. The Journal of Biological Chemistry. 270: 11719-22. PMID 7744814 DOI: 10.1074/Jbc.270.20.11719  0.362
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