Anna E. Speers, Ph.D. - Publications

Affiliations: 
2005 Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
Medicinal Chemistry

26 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Chang JW, Zuhl AM, Speers AE, Niessen S, Brown SJ, Mulvihill MM, Fan YC, Spicer TP, Southern M, Scampavia L, Fernandez-Vega V, Dix MM, Cameron MD, Hodder PS, Rosen H, et al. Selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival. Acs Chemical Biology. 10: 925-32. PMID 25602368 DOI: 10.1021/cb500893q  1
2015 Zhao N, Darby CM, Small J, Bachovchin DA, Jiang X, Burns-Huang KE, Botella H, Ehrt S, Boger DL, Anderson ED, Cravatt BF, Speers AE, Fernandez-Vega V, Hodder PS, Eberhart C, et al. Target-based screen against a periplasmic serine protease that regulates intrabacterial pH homeostasis in Mycobacterium tuberculosis. Acs Chemical Biology. 10: 364-71. PMID 25457457 DOI: 10.1021/cb500746z  1
2013 Ward J, Spath SN, Pabst B, Carpino PA, Ruggeri RB, Xing G, Speers AE, Cravatt BF, Ahn K. Mechanistic characterization of a 2-thioxanthine myeloperoxidase inhibitor and selectivity assessment utilizing click chemistry--activity-based protein profiling. Biochemistry. 52: 9187-201. PMID 24320749 DOI: 10.1021/bi401354d  1
2013 Hsu KL, Tsuboi K, Chang JW, Whitby LR, Speers AE, Pugh H, Cravatt BF. Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (ABHD6). Journal of Medicinal Chemistry. 56: 8270-9. PMID 24152295 DOI: 10.1021/jm400899c  1
2013 Hsu KL, Tsuboi K, Whitby LR, Speers AE, Pugh H, Inloes J, Cravatt BF. Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis. Journal of Medicinal Chemistry. 56: 8257-69. PMID 24152245 DOI: 10.1021/jm400898x  1
2013 Nagano JM, Hsu KL, Whitby LR, Niphakis MJ, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Hodder P, Srinivasan P, Gonzalez TD, Rosen H, Bahnson BJ, Cravatt BF. Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2). Bioorganic & Medicinal Chemistry Letters. 23: 839-43. PMID 23260346 DOI: 10.1016/j.bmcl.2012.11.061  1
2012 Liu X, Dix M, Speers AE, Bachovchin DA, Zuhl AM, Cravatt BF, Kodadek TJ. Rapid development of a potent photo-triggered inhibitor of the serine hydrolase RBBP9. Chembiochem : a European Journal of Chemical Biology. 13: 2082-93. PMID 22907802 DOI: 10.1002/cbic.201200445  1
2012 Saario SM, McKinney MK, Speers AE, Wang C, Cravatt BF. Clickable, photoreactive inhibitors to probe the active site microenvironment of fatty acid amide hydrolase(). Chemical Science (Royal Society of Chemistry : 2010). 3: 77-83. PMID 22737400 DOI: 10.1039/C1SC00336D  1
2012 Adibekian A, Martin BR, Chang JW, Hsu KL, Tsuboi K, Bachovchin DA, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Hodder PS, Rosen H, Cravatt BF. Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes. Journal of the American Chemical Society. 134: 10345-8. PMID 22690931 DOI: 10.1021/ja303400u  1
2011 Rowland MM, Bostic HE, Gong D, Speers AE, Lucas N, Cho W, Cravatt BF, Best MD. Phosphatidylinositol 3,4,5-trisphosphate activity probes for the labeling and proteomic characterization of protein binding partners. Biochemistry. 50: 11143-61. PMID 22074223 DOI: 10.1021/bi201636s  1
2011 Tsuboi K, Bachovchin DA, Speers AE, Spicer TP, Fernandez-Vega V, Hodder P, Rosen H, Cravatt BF. Potent and selective inhibitors of glutathione S-transferase omega 1 that impair cancer drug resistance. Journal of the American Chemical Society. 133: 16605-16. PMID 21899313 DOI: 10.1021/ja2066972  1
2011 Lone AM, Bachovchin DA, Westwood DB, Speers AE, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Rosen H, Cravatt BF, Saghatelian A. A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors. Journal of the American Chemical Society. 133: 11665-74. PMID 21692504 DOI: 10.1021/ja2036095  1
2011 Bachovchin DA, Zuhl AM, Speers AE, Wolfe MR, Weerapana E, Brown SJ, Rosen H, Cravatt BF. Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1. Journal of Medicinal Chemistry. 54: 5229-36. PMID 21639134 DOI: 10.1021/jm200502u  1
2011 Bachovchin DA, Mohr JT, Speers AE, Wang C, Berlin JM, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Schürer SC, Nomura DK, Rosen H, Fu GC, Cravatt BF. Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 108: 6811-6. PMID 21398589 DOI: 10.1073/pnas.1015248108  1
2010 Speers AE, Cravatt BF. Ligands in crystal structures that aid in functional characterization. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1306-8. PMID 20944226 DOI: 10.1107/S1744309110035748  1
2009 Speers AE, Cravatt BF. Activity-Based Protein Profiling (ABPP) and Click Chemistry (CC)-ABPP by MudPIT Mass Spectrometry. Current Protocols in Chemical Biology. 1: 29-41. PMID 21701697 DOI: 10.1002/9780470559277.ch090138  1
2008 Blackler AR, Speers AE, Wu CC. Chromatographic benefits of elevated temperature for the proteomic analysis of membrane proteins. Proteomics. 8: 3956-64. PMID 18780350 DOI: 10.1002/pmic.200800210  1
2008 Blackler AR, Speers AE, Ladinsky MS, Wu CC. A shotgun proteomic method for the identification of membrane-embedded proteins and peptides. Journal of Proteome Research. 7: 3028-34. PMID 18537282 DOI: 10.1021/pr700795f  1
2008 Speers AE, Wu CC. Chapter 10 Bottom-Up Mass Spectrometry Analysis of Integral Membrane Protein Structure and Topology Comprehensive Analytical Chemistry. 52: 213-243. DOI: 10.1016/S0166-526X(08)00210-9  1
2007 Speers AE, Wu CC. Proteomics of integral membrane proteins--theory and application. Chemical Reviews. 107: 3687-714. PMID 17683161 DOI: 10.1021/cr068286z  1
2007 Weerapana E, Speers AE, Cravatt BF. Tandem orthogonal proteolysis-activity-based protein profiling (TOP-ABPP)--a general method for mapping sites of probe modification in proteomes. Nature Protocols. 2: 1414-25. PMID 17545978 DOI: 10.1038/nprot.2007.194  1
2007 Speers AE, Blackler AR, Wu CC. Shotgun analysis of integral membrane proteins facilitated by elevated temperature. Analytical Chemistry. 79: 4613-20. PMID 17500534 DOI: 10.1021/ac0700225  1
2005 Speers AE, Cravatt BF. A tandem orthogonal proteolysis strategy for high-content chemical proteomics. Journal of the American Chemical Society. 127: 10018-9. PMID 16011363 DOI: 10.1021/ja0532842  1
2004 Speers AE, Cravatt BF. Profiling enzyme activities in vivo using click chemistry methods. Chemistry & Biology. 11: 535-46. PMID 15123248 DOI: 10.1016/j.chembiol.2004.03.012  1
2004 Speers AE, Cravatt BF. Chemical strategies for activity-based proteomics. Chembiochem : a European Journal of Chemical Biology. 5: 41-7. PMID 14695510 DOI: 10.1002/cbic.200300721  1
2003 Speers AE, Adam GC, Cravatt BF. Activity-based protein profiling in vivo using a copper(i)-catalyzed azide-alkyne [3 + 2] cycloaddition. Journal of the American Chemical Society. 125: 4686-7. PMID 12696868 DOI: 10.1021/ja034490h  1
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