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James M. Chen - Publications

Affiliations: 
Pharmaceutical Industry 
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35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2004 Chie L, Friedman FK, Duncan T, Chen JM, Chung D, Pincus M. Loop domain peptides from the SOS ras-guanine nucleotide exchange protein, identified from molecular dynamics calculations, strongly inhibit ras signaling. The Protein Journal. 23: 229-34. PMID 15200054 DOI: 10.1023/B:Jopc.0000026418.82786.5E  0.386
2004 Duncan T, Chen JM, Friedman FK, Hyde M, Chie L, Pincus MR. Comparison of molecular dynamics averaged structures for complexes of normal and oncogenic ras-p21 with SOS nucleotide exchange protein, containing computed conformations for three crystallographically undefined domains, suggests a potential role of these domains in ras signaling. The Protein Journal. 23: 217-28. PMID 15200053 DOI: 10.1023/B:Jopc.0000026417.72621.1F  0.427
2002 Chen JM, Friedman FK, Brandt-Rauf PW, Pincus MR, Chie L. Comparison of the average structures, from molecular dynamics, of complexes of GTPase activating protein (GAP) with oncogenic and wild-type ras-p21: identification of potential effector domains. Journal of Protein Chemistry. 21: 349-59. PMID 12206509 DOI: 10.1023/A:1019994302273  0.405
2000 Chen JM, Rijhwani K, Friedman FK, Hyde MJ, Pincus MR. Identification, using molecular dynamics, of an effector domain of the ras-binding domain of the raf-p74 protein that is uniquely involved in oncogenic ras-p21 signaling Journal of Protein Chemistry. 19: 545-551. PMID 11233167 DOI: 10.1023/A:1007127700199  0.441
1999 Chie L, Chen JM, Friedman FK, Chung DL, Amar S, Michl J, Yamaizumi Z, Brandt-Rauf PW, Pincus MR. Identification of the site of inhibition of oncogenic ras-p21-induced signal transduction by a peptide from a ras effector domain. Journal of Protein Chemistry. 18: 881-4. PMID 10839625 DOI: 10.1023/A:1020635414089  0.386
1999 Chie L, Chen JM, Friedman FK, Chung DL, Amar S, Michl J, Yamaizumi Z, Brandt-Rauf PW, Pincus MR. Inhibition of oncogenic and activated wild-type ras-p21 protein-induced oocyte maturation by peptides from the guanine-nucleotide exchange protein, SOS, identified from molecular dynamics calculations. Selective inhibition of oncogenic ras-p21. Journal of Protein Chemistry. 18: 875-9. PMID 10839624 DOI: 10.1023/A:1020683330019  0.45
1999 Chen JM, Friedman FK, Hyde MJ, Monaco R, Pincus MR. Molecular dynamics analysis of the structures of ras-guanine nucleotide exchange protein (SOS) bound to wild-type and oncogenic ras-p21. Identification of effector domains of SOS. Journal of Protein Chemistry. 18: 867-74. PMID 10839623 DOI: 10.1023/A:1020631313180  0.48
1999 Monaco R, Friedman FK, Hyde MJ, Chen JM, Manolatus S, Adler V, Ronai Z, Koslosky W, Pincus MR. Identification of a glutathione-S-transferase effector domain for inhibition of jun kinase, by molecular dynamics. Journal of Protein Chemistry. 18: 859-66. PMID 10839622 DOI: 10.1023/A:1020679229110  0.395
1999 Chen JM, Smith SJ, Marion MJ, Pincus MR, Brandt-Rauf PW. Common conformational effects in the p53 protein of vinyl chloride-induced mutations. Journal of Protein Chemistry. 18: 467-72. PMID 10449043 DOI: 10.1023/A:1020644826867  0.445
1997 Chung D, Amar S, Glozman A, Chen JM, Friedman FK, Robinson R, Monaco R, Brandt-Rauf P, Yamaizumi Z, Pincus MR. Inhibition of oncogenic and activated wild-type ras-p21 protein-induced oocyte maturation by peptides from the ras-binding domain of the raf-p74 protein, identified from molecular dynamics calculations. Journal of Protein Chemistry. 16: 631-5. PMID 9263125 DOI: 10.1023/A:1026374908495  0.381
1997 Chen JM, Monaco R, Manolatos S, Brandt-Rauf PW, Friedman FK, Pincus MR. Molecular dynamics on complexes of ras-p21 and its inhibitor protein, rap-1A, bound to the ras-binding domain of the raf-p74 protein: identification of effector domains in the raf protein. Journal of Protein Chemistry. 16: 619-29. PMID 9263124 DOI: 10.1023/A:1026322924424  0.395
1997 Adler V, Pincus MR, Minamoto T, Fuchs SY, Bluth MJ, Brandt-Rauf PW, Friedman FK, Robinson RC, Chen JM, Wang XW, Harris CC, Ronai Z. Conformation-dependent phosphorylation of p53. Proceedings of the National Academy of Sciences of the United States of America. 94: 1686-91. PMID 9050839 DOI: 10.1073/Pnas.94.5.1686  0.352
1996 Chen JM, Manolatos S, Brandt-Rauf PW, Murphy RB, Monaco R, Pincus MR. Computed three-dimensional structures for the ras-binding domain of the raf-p74 protein complexed with ras-p21 and with its suppressor protein, rap-1A. Journal of Protein Chemistry. 15: 511-8. PMID 8895097 DOI: 10.1007/Bf01908532  0.607
1996 Chen JM, Grad R, Monaco R, Pincus MR. Prediction of the three-dimensional structure of the rap-1A protein from its homology to the ras-gene-encoded p21 protein. Journal of Protein Chemistry. 15: 11-5. PMID 8838585 DOI: 10.1007/BF01886806  0.404
1996 Chen JM, Brandt-Rauf PW, Pincus MR. Oncogenic amino acid substitutions in the inhibitory rap-1A protein cause it to adopt a ras-p21-like conformation as computed using molecular dynamics. Journal of Biomolecular Structure & Dynamics. 13: 925-33. PMID 8832375 DOI: 10.1080/07391102.1996.10508907  0.339
1996 Brandt-Rauf PW, Chen JM, Marion MJ, Smith SJ, Luo JC, Carney W, Pincus MR. Conformational effects in the p53 protein of mutations induced during chemical carcinogenesis: molecular dynamic and immunologic analyses. Journal of Protein Chemistry. 15: 367-75. PMID 8819013 DOI: 10.1007/Bf01886863  0.325
1996 Monaco R, Chen JM, Friedman FK, Brandt-Rauf P, Chung D, Pincus MR. Structural effects of the binding of GTP to the wild-type and oncogenic forms of the ras-gene-encoded p21 proteins. Journal of Protein Chemistry. 14: 721-9. PMID 8747433 DOI: 10.1007/Bf01886911  0.388
1996 Monaco R, Chen JM, Chung D, Brandt-Rauf P, Pincus MR. Comparison of the computed three-dimensional structures of oncogenic forms (bound to GDP) of the ras-gene-encoded p21 protein with the structure of the normal (non-transforming) wild-type protein. Journal of Protein Chemistry. 14: 457-66. PMID 8593186 DOI: 10.1007/BF01888140  0.439
1993 Chen JM, Sheldon A, Pincus MR. Structure-function correlations of calcium binding and calcium channel activities based on 3-dimensional models of human annexins I, II, III, V and VII. Journal of Biomolecular Structure & Dynamics. 10: 1067-89. PMID 8395183 DOI: 10.1080/07391102.1993.10508696  0.373
1992 Murphy RB, Pincus MR, Beinfeld M, Dykes DC, Chen JM, Schneider LH, Gibbs J, Smith GP. Enkephalin is a competitive antagonist of cholecystokinin in the gastrointestinal tract, as predicted from prior conformational analysis. Journal of Protein Chemistry. 11: 723-9. PMID 1466765 DOI: 10.1007/Bf01024973  0.624
1990 Brandt-Rauf PW, Pincus MR, Chen JM. Conformational changes induced by the transforming amino acid substitution in the transmembrane domain of the neu oncogene-encoded p185 protein. Journal of Protein Chemistry. 8: 749-56. PMID 2576207 DOI: 10.1007/Bf01024899  0.489
1990 Chen JM, Lee G, Brandt-Rauf PW, Murphy RB, Gibson KD, Scheraga HA, Rackovsky S, Pincus MR. Conformations of the central transforming region (Ile 55-Met 67) of the p21 protein and their relationship to activation of the protein. International Journal of Peptide and Protein Research. 36: 247-54. PMID 2279848 DOI: 10.1111/J.1399-3011.1990.Tb00975.X  0.674
1990 Chen JM, Lee G, Murphy RB, Brandt-Rauf PW, Pincus MR. Comparisons between the three-dimensional structures of the chemotactic protein CheY and the normal Gly 12-p21 protein. International Journal of Peptide and Protein Research. 36: 1-6. PMID 2205595 DOI: 10.1111/J.1399-3011.1990.Tb00077.X  0.692
1990 Brandt-Rauf PW, Carty RP, Chen JM, Lee G, Rackovsky S, Pincus MR. The structure of the carboxyl terminus of the p21 protein. Structural relationship to the nucleotide-binding/transforming regions of the protein. Journal of Protein Chemistry. 9: 137-42. PMID 2201311 DOI: 10.1007/Bf01025304  0.588
1990 Chen JM, Lee G, Brandt-Rauf PW, Murphy RB, Rackovsky S, Pincus MR. Comparison of the predicted structure for the activated form of the P21 protein with the X-ray crystal structure. Journal of Protein Chemistry. 9: 543-7. PMID 2085379 DOI: 10.1007/Bf01025007  0.687
1989 Chen JM, Lee G, Murphy RB, Carty RP, Brandt-Rauf PW, Friedman E, Pincus MR. Comparison of the computed structures for the phosphate-binding loop of the p21 protein containing the oncogenic site Gly 12 with the X-ray crystallographic structures for this region in the p21 protein and EFtu. A model for the structure of the p21 protein in its oncogenic form. Journal of Biomolecular Structure & Dynamics. 6: 859-75. PMID 2686707 DOI: 10.1080/07391102.1989.10506518  0.719
1989 Shah D, Chen JM, Carty RP, Pincus MR, Scheraga HA. Correlation of beta-bend conformations of tetrapeptides with their activities in CD4-receptor binding assays. International Journal of Peptide and Protein Research. 34: 325-32. PMID 2599773 DOI: 10.1111/J.1399-3011.1989.Tb01582.X  0.447
1989 Brandt-Rauf PW, Lee G, Carty RP, Pincus MR, Chen JM. Conformational effects of amino acid substitutions in the P-glycoprotein of the mdr 1 gene Journal of Protein Chemistry. 8: 563-573. PMID 2572237 DOI: 10.1007/Bf01026439  0.516
1989 Chen J, Barber A, Pedersen J, Brandt-Rauf PW, Carucci J, Murphy RB, Carty RP, Licht D, Pincus MR. Comparative X-ray crystallographic evidence for a beta-bend conformation as the active structure for peptide T in T4 receptor recognition. Journal of Protein Chemistry. 8: 87-100. PMID 2548525 DOI: 10.1007/Bf01025081  0.66
1989 Brandt-Rauf PW, Pincus MR, Chen JM, Lee G. Conformational energy analysis of the leucine repeat regions of C/EBP, GCN4, and the proteins of the myc, jun, and fos oncogenes Journal of Protein Chemistry. 8: 679-688. PMID 2532887 DOI: 10.1007/Bf01025608  0.567
1988 Longo PA, Broido MS, Chen J, Kung HF, Pincus MR. The structure of the amino terminal transforming segment of the p21 protein, Tyr4-Thr20 (with Asp12), by two-dimensional NMR Biochemical and Biophysical Research Communications. 157: 776-782. PMID 3144279 DOI: 10.1016/S0006-291X(88)80317-6  0.544
1988 Brandt-Rauf PW, Carty RP, Chen J, Avitable M, Lubowsky J, Pincus MR. Structure of the carboxyl terminus of the RAS gene-encoded P21 proteins. Proceedings of the National Academy of Sciences of the United States of America. 85: 5869-73. PMID 3045806 DOI: 10.1073/Pnas.85.16.5869  0.421
1988 Pincus MR, Murphy RB, Carty RP, Chen J, Shah D, Scheraga HA. Conformational analysis of possible biologically active (receptor-bound) conformations of peptides derived from cholecystokinin, cerulein and little gastrin and the opiate peptide, Met-enkephalin. Peptides. 9: 145-52. PMID 2856638 DOI: 10.1016/0196-9781(88)90238-0  0.625
1987 Pincus MR, Carty RP, Chen J, Lubowsky J, Avitable M, Shah D, Scheraga HA, Murphy RB. On the biologically active structures of cholecystokinin, little gastrin, and enkephalin in the gastrointestinal system. Proceedings of the National Academy of Sciences of the United States of America. 84: 4821-5. PMID 3037525 DOI: 10.1073/Pnas.84.14.4821  0.624
1987 Pincus MR, Carty RP, Chen J, Murphy RB. A strong homology exists between the active T-cell binding gp120 octapeptide of human immunodeficiency virus and the subtilisin cleavage peptide of bovine ribonuclease A. Biochemical and Biophysical Research Communications. 143: 248-51. PMID 3030317 DOI: 10.1016/0006-291X(87)90657-7  0.659
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