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Robert S. Freeman - Publications

Affiliations: 
University of Rochester, Rochester, NY 
Area:
Developmental Cell Ceath in the Nervous System
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37 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Papasergi-Scott MM, Stoveken HM, MacConnachie L, Chan PY, Gabay M, Wong D, Freeman RS, Beg AA, Tall GG. Dual phosphorylation of Ric-8A enhances its ability to mediate G protein α subunit folding and to stimulate guanine nucleotide exchange. Science Signaling. 11. PMID 29844055 DOI: 10.1126/Scisignal.Aap8113  0.729
2011 Guo H, Barrett TM, Zhong Z, Fernández JA, Griffin JH, Freeman RS, Zlokovic BV. Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway. Molecular Neurodegeneration. 6: 13. PMID 21291561 DOI: 10.1186/1750-1326-6-13  0.504
2010 Zhong Z, Wang Y, Guo H, Sagare A, Fernández JA, Bell RD, Barrett TM, Griffin JH, Freeman RS, Zlokovic BV. Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 15521-34. PMID 21084607 DOI: 10.1523/Jneurosci.4437-10.2010  0.501
2009 Guo Y, Schoell MC, Freeman RS. The von Hippel-Lindau protein sensitizes renal carcinoma cells to apoptotic stimuli through stabilization of BIM(EL). Oncogene. 28: 1864-74. PMID 19305426 DOI: 10.1038/onc.2009.35  0.548
2009 Lomb DJ, Desouza LA, Franklin JL, Freeman RS. Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2alpha to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2alpha has a role in NGF-promoted survival of sympathetic neurons. Molecular Pharmacology. 75: 1198-209. PMID 19204094 DOI: 10.1124/Mol.108.053157  0.771
2008 Ratan RR, Siddiq A, Aminova L, Langley B, McConoughey S, Karpisheva K, Lee HH, Carmichael T, Kornblum H, Coppola G, Geschwind DH, Hoke A, Smirnova N, Rink C, Roy S, ... ... Freeman RS, et al. Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury. Annals of the New York Academy of Sciences. 1147: 383-94. PMID 19076458 DOI: 10.1196/Annals.1427.033  0.394
2008 Barone MC, Desouza LA, Freeman RS. Pin1 promotes cell death in NGF-dependent neurons through a mechanism requiring c-Jun activity. Journal of Neurochemistry. 106: 734-45. PMID 18419764 DOI: 10.1111/J.1471-4159.2008.05427.X  0.841
2007 Lomb DJ, Straub JA, Freeman RS. Prolyl hydroxylase inhibitors delay neuronal cell death caused by trophic factor deprivation. Journal of Neurochemistry. 103: 1897-906. PMID 17760870 DOI: 10.1111/J.1471-4159.2007.04873.X  0.812
2007 Fu J, Menzies K, Freeman RS, Taubman MB. EGLN3 prolyl hydroxylase regulates skeletal muscle differentiation and myogenin protein stability. The Journal of Biological Chemistry. 282: 12410-8. PMID 17344222 DOI: 10.1074/Jbc.M608748200  0.355
2005 Lee S, Nakamura E, Yang H, Wei W, Linggi MS, Sajan MP, Farese RV, Freeman RS, Carter BD, Kaelin WG, Schlisio S. Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer. Cancer Cell. 8: 155-67. PMID 16098468 DOI: 10.1016/J.Ccr.2005.06.015  0.562
2005 Xie L, Johnson RS, Freeman RS. Inhibition of NGF deprivation-induced death by low oxygen involves suppression of BIMEL and activation of HIF-1. The Journal of Cell Biology. 168: 911-20. PMID 15767462 DOI: 10.1083/Jcb.200407079  0.477
2005 Freeman RS, Barone MC. Targeting hypoxia-inducible factor (HIF) as a therapeutic strategy for CNS disorders. Current Drug Targets. Cns and Neurological Disorders. 4: 85-92. PMID 15723616 DOI: 10.2174/1568007053005154  0.363
2005 Clifton DR, Rydkina E, Freeman RS, Sahni SK. NF-kappaB activation during Rickettsia rickettsii infection of endothelial cells involves the activation of catalytic IkappaB kinases IKKalpha and IKKbeta and phosphorylation-proteolysis of the inhibitor protein IkappaBalpha. Infection and Immunity. 73: 155-65. PMID 15618150 DOI: 10.1128/Iai.73.1.155-165.2005  0.372
2004 Farhana L, Dawson MI, Huang Y, Zhang Y, Rishi AK, Reddy KB, Freeman RS, Fontana JA. Apoptosis signaling by the novel compound 3-Cl-AHPC involves increased EGFR proteolysis and accompanying decreased phosphatidylinositol 3-kinase and AKT kinase activities. Oncogene. 23: 1874-84. PMID 14981538 DOI: 10.1038/Sj.Onc.1207311  0.404
2004 Freeman RS, Burch RL, Crowder RJ, Lomb DJ, Schoell MC, Straub JA, Xie L. NGF deprivation-induced gene expression: after ten years, where do we stand? Progress in Brain Research. 146: 111-26. PMID 14699960 DOI: 10.1016/S0079-6123(03)46008-1  0.797
2003 Freeman RS, Hasbani DM, Lipscomb EA, Straub JA, Xie L. SM-20, EGL-9, and the EGLN family of hypoxia-inducible factor prolyl hydroxylases. Molecules and Cells. 16: 1-12. PMID 14503838  0.774
2003 Besirli CG, Deckwerth TL, Crowder RJ, Freeman RS, Johnson EM. Cytosine arabinoside rapidly activates Bax-dependent apoptosis and a delayed Bax-independent death pathway in sympathetic neurons. Cell Death and Differentiation. 10: 1045-58. PMID 12934079 DOI: 10.1038/Sj.Cdd.4401259  0.674
2003 Straub JA, Lipscomb EA, Yoshida ES, Freeman RS. Induction of SM-20 in PC12 cells leads to increased cytochrome c levels, accumulation of cytochrome c in the cytosol, and caspase-dependent cell death. Journal of Neurochemistry. 85: 318-28. PMID 12675908 DOI: 10.1046/J.1471-4159.2003.01688.X  0.818
2002 Wolf G, Harendza S, Schroeder R, Wenzel U, Zahner G, Butzmann U, Freeman RS, Stahl RA. Angiotensin II's antiproliferative effects mediated through AT2-receptors depend on down-regulation of SM-20. Laboratory Investigation; a Journal of Technical Methods and Pathology. 82: 1305-17. PMID 12379765 DOI: 10.1097/01.LAB.0000029207.92039.2F  0.34
2001 Sarmiere PD, Freeman RS. Analysis of the NF-kappa B and PI 3-kinase/Akt survival pathways in nerve growth factor-dependent neurons. Molecular and Cellular Neurosciences. 18: 320-31. PMID 11591132 DOI: 10.1006/Mcne.2001.1021  0.828
2001 Lipscomb EA, Sarmiere PD, Freeman RS. SM-20 is a novel mitochondrial protein that causes caspase-dependent cell death in nerve growth factor-dependent neurons. The Journal of Biological Chemistry. 276: 5085-92. PMID 11060309 DOI: 10.1074/Jbc.M008407200  0.814
2000 Crowder RJ, Freeman RS. Glycogen synthase kinase-3 beta activity is critical for neuronal death caused by inhibiting phosphatidylinositol 3-kinase or Akt but not for death caused by nerve growth factor withdrawal. The Journal of Biological Chemistry. 275: 34266-71. PMID 10954722 DOI: 10.1074/jbc.M006160200  0.484
1999 Crowder RJ, Freeman RS. The survival of sympathetic neurons promoted by potassium depolarization, but not by cyclic AMP, requires phosphatidylinositol 3-kinase and Akt. Journal of Neurochemistry. 73: 466-75. PMID 10428041 DOI: 10.1046/j.1471-4159.1999.0730466.x  0.52
1999 Lipscomb EA, Sarmiere PD, Crowder RJ, Freeman RS. Expression of the SM-20 gene promotes death in nerve growth factor-dependent sympathetic neurons. Journal of Neurochemistry. 73: 429-32. PMID 10386996 DOI: 10.1046/J.1471-4159.1999.0730429.X  0.822
1998 Maggirwar SB, Sarmiere PD, Dewhurst S, Freeman RS. Nerve growth factor-dependent activation of NF-kappaB contributes to survival of sympathetic neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 10356-65. PMID 9852573  0.835
1998 Crowder RJ, Freeman RS. Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 2933-43. PMID 9526010 DOI: 10.1523/Jneurosci.18-08-02933.1998  0.584
1998 Maggirwar SB, Sarmiere PD, Dewhurst S, Freeman RS. Nerve Growth Factor-Dependent Activation of NF-κB Contributes to Survival of Sympathetic Neurons The Journal of Neuroscience. 18: 10356-10365. DOI: 10.1523/Jneurosci.18-24-10356.1998  0.832
1994 Freeman RS, Estus S, Johnson EM. Analysis of cell cycle-related gene expression in postmitotic neurons: selective induction of Cyclin D1 during programmed cell death. Neuron. 12: 343-55. PMID 8110463 DOI: 10.1016/0896-6273(94)90276-3  0.672
1994 Estus S, Zaks WJ, Freeman RS, Gruda M, Bravo R, Johnson EM. Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis. The Journal of Cell Biology. 127: 1717-27. PMID 7798322 DOI: 10.1083/Jcb.127.6.1717  0.687
1993 Smith CJ, Johnson EM, Osborne P, Freeman RS, Neveu I, Brachet P. NGF deprivation and neuronal degeneration trigger altered beta-amyloid precursor protein gene expression in the rat superior cervical ganglia in vivo and in vitro. Brain Research. Molecular Brain Research. 17: 328-34. PMID 8510504 DOI: 10.1016/0169-328X(93)90018-K  0.619
1993 Freeman RS, Estus S, Horigome K, Johnson EM. Cell death genes in invertebrates and (maybe) vertebrates. Current Opinion in Neurobiology. 3: 25-31. PMID 8453285 DOI: 10.1016/0959-4388(93)90031-S  0.571
1992 Freeman RS, Meyer AN, Li J, Donoghue DJ. Phosphorylation of conserved serine residues does not regulate the ability of mosxe protein kinase to induce oocyte maturation or function as cytostatic factor. The Journal of Cell Biology. 116: 725-35. PMID 1530949 DOI: 10.1083/Jcb.116.3.725  0.586
1991 Freeman RS, Donoghue DJ. Protein kinases and protooncogenes: biochemical regulators of the eukaryotic cell cycle. Biochemistry. 30: 2293-302. PMID 2001361 DOI: 10.1021/Bi00223A001  0.585
1991 Freeman RS, Ballantyne SM, Donoghue DJ. Meiotic induction by Xenopus cyclin B is accelerated by coexpression with mosXe. Molecular and Cellular Biology. 11: 1713-7. PMID 1825350 DOI: 10.1128/Mcb.11.3.1713  0.542
1990 Freeman RS, Kanki JP, Ballantyne SM, Pickham KM, Donoghue DJ. Effects of the v-mos oncogene on Xenopus development: meiotic induction in oocytes and mitotic arrest in cleaving embryos. The Journal of Cell Biology. 111: 533-41. PMID 2143197 DOI: 10.1083/Jcb.111.2.533  0.565
1989 Freeman RS, Donoghue DJ. Transforming mutant v-mos protein kinases that are deficient in in vitro autophosphorylation. Molecular and Cellular Biology. 9: 4087-90. PMID 2528689 DOI: 10.1128/Mcb.9.9.4087  0.57
1989 Freeman RS, Pickham KM, Kanki JP, Lee BA, Pena SV, Donoghue DJ. Xenopus homolog of the mos protooncogene transforms mammalian fibroblasts and induces maturation of Xenopus oocytes. Proceedings of the National Academy of Sciences of the United States of America. 86: 5805-9. PMID 2527365 DOI: 10.1073/Pnas.86.15.5805  0.607
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