David S. Segal - Publications

Affiliations: 
University of California, San Diego, La Jolla, CA 
Area:
Neuropharmacology

141 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2009 Kuczenski R, Segal DS, Melega WP, Lacan G, McCunney SJ. Human methamphetamine pharmacokinetics simulated in the rat: behavioral and neurochemical effects of a 72-h binge. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 2430-41. PMID 19571794 DOI: 10.1038/npp.2009.73  1
2007 Clark RE, Kuczenski R, Segal DS. Escalating dose, multiple binge methamphetamine regimen does not impair recognition memory in rats. Synapse (New York, N.Y.). 61: 515-22. PMID 17415795 DOI: 10.1002/syn.20397  1
2006 O'Neil ML, Kuczenski R, Segal DS, Cho AK, Lacan G, Melega WP. Escalating dose pretreatment induces pharmacodynamic and not pharmacokinetic tolerance to a subsequent high-dose methamphetamine binge. Synapse (New York, N.Y.). 60: 465-73. PMID 16897726 DOI: 10.1002/syn.20320  1
2006 Shilling PD, Kuczenski R, Segal DS, Barrett TB, Kelsoe JR. Differential regulation of immediate-early gene expression in the prefrontal cortex of rats with a high vs low behavioral response to methamphetamine. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 2359-67. PMID 16855532 DOI: 10.1038/sj.npp.1301162  1
2006 Segal DS, Kuczenski R. Human methamphetamine pharmacokinetics simulated in the rat: single daily intravenous administration reveals elements of sensitization and tolerance. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 941-55. PMID 16123749 DOI: 10.1038/sj.npp.1300865  1
2005 Segal DS, Kuczenski R, O'Neil ML, Melega WP, Cho AK. Prolonged exposure of rats to intravenous methamphetamine: behavioral and neurochemical characterization. Psychopharmacology. 180: 501-12. PMID 15959831 DOI: 10.1007/s00213-005-2188-4  1
2005 Kuczenski R, Segal DS. Stimulant actions in rodents: implications for attention-deficit/hyperactivity disorder treatment and potential substance abuse. Biological Psychiatry. 57: 1391-6. PMID 15950013 DOI: 10.1016/j.biopsych.2004.12.036  1
2003 Feifel D, Shilling PD, Kuczenski R, Segal DS. Altered extracellular dopamine concentration in the brains of cholecystokinin-A receptor deficient rats. Neuroscience Letters. 348: 147-50. PMID 12932815 DOI: 10.1016/S0304-3940(03)00767-5  1
2003 Segal DS, Kuczenski R, O'Neil ML, Melega WP, Cho AK. Escalating dose methamphetamine pretreatment alters the behavioral and neurochemical profiles associated with exposure to a high-dose methamphetamine binge. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 1730-40. PMID 12865898 DOI: 10.1038/sj.npp.1300247  1
2002 Kuczenski R, Segal DS. Exposure of adolescent rats to oral methylphenidate: preferential effects on extracellular norepinephrine and absence of sensitization and cross-sensitization to methamphetamine. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 7264-71. PMID 12177221  1
2001 Kuczenski R, Segal DS. Caudate-putamen and nucleus accumbens extracellular acetylcholine responses to methamphetamine binges. Brain Research. 923: 32-8. PMID 11743969 DOI: 10.1016/S0006-8993(01)03193-6  1
2001 Kuczenski R, Segal DS. Locomotor effects of acute and repeated threshold doses of amphetamine and methylphenidate: relative roles of dopamine and norepinephrine. The Journal of Pharmacology and Experimental Therapeutics. 296: 876-83. PMID 11181919  1
2001 Cho AK, Melega WP, Kuczenski R, Segal DS. Relevance of pharmacokinetic parameters in animal models of methamphetamine abuse. Synapse (New York, N.Y.). 39: 161-6. PMID 11180503 DOI: 10.1002/1098-2396(200102)39:2<161::AID-SYN7>3.0.CO;2-E  1
2001 Niculescu AB, Segal DS, Kuczenski R, Barrett T, Hauger RL, Kelsoe JR. Identifying a series of candidate genes for mania and psychosis: A convergent functional genomics approach Physiological Genomics. 2001: 83-91.  1
2000 Niculescu AB, Segal DS, Kuczenski R, Barrett T, Hauger RL, Kelsoe JR. Identifying a series of candidate genes for mania and psychosis: a convergent functional genomics approach. Physiological Genomics. 4: 83-91. PMID 11074017  1
2000 Shilling PD, Kelsoe JR, Kuczenski R, Segal DS. Differential regional zif268 messenger RNA expression in an escalating dose/binge model of amphetamine-induced psychosis. Neuroscience. 96: 83-90. PMID 10683413 DOI: 10.1016/S0306-4522(99)00510-2  1
2000 Niculescu AB, Hauger RL, Segal DS, Kuczenski R, Barrett T, Kelsoe JR. A convergent functional genomics approach identifies GRK3 as a candidate gene for bipolar disordr on 22q American Journal of Medical Genetics - Neuropsychiatric Genetics. 96: 483.  1
2000 Niculescu AB, Segal DS, Kuczenski R, Barrett T, Hauger R, Kelsoe JR. Identifying candidate genes for mania and psychosis using a convergent functional genomics approach American Journal of Medical Genetics - Neuropsychiatric Genetics. 96: 481.  1
1999 Kuczenski R, Segal DS. Dynamic changes in sensitivity occur during the acute response to cocaine and methylphenidate. Psychopharmacology. 147: 96-103. PMID 10591874 DOI: 10.1007/s002130051147  1
1999 Segal DS, Kuczenski R. Escalating dose-binge treatment with methylphenidate: role of serotonin in the emergent behavioral profile. The Journal of Pharmacology and Experimental Therapeutics. 291: 19-30. PMID 10490882  1
1999 Segal DS, Kuczenski R. Escalating dose-binge stimulant exposure: relationship between emergent behavioral profile and differential caudate-putamen and nucleus accumbens dopamine responses. Psychopharmacology. 142: 182-92. PMID 10102771 DOI: 10.1007/s002130050878  1
1999 Kuczenski R, Segal DS. Sensitization of amphetamine-induced stereotyped behaviors during the acute response: role of D1 and D2 dopamine receptors. Brain Research. 822: 164-74. PMID 10082894 DOI: 10.1016/S0006-8993(99)01149-X  1
1999 Cho AK, Melega WP, Kuczenski R, Segal DS, Schmitz DA. Caudate-putamen dopamine and stereotypy response profiles after intravenous and subcutaneous amphetamine. Synapse (New York, N.Y.). 31: 125-33. PMID 10024009 DOI: 10.1002/(SICI)1098-2396(199902)31:2<125::AID-SYN5>3.0.CO;2-W  1
1999 Melega WP, Cho AK, Schmitz D, Kuczenski R, Segal DS. l-methamphetamine pharmacokinetics and pharmacodynamics for assessment of in vivo deprenyl-derived l-methamphetamine. The Journal of Pharmacology and Experimental Therapeutics. 288: 752-8. PMID 9918585  1
1999 Kuczenski R, Segal DS. Sensitization of amphetamine-induced stereotyped behaviors during the acute response. The Journal of Pharmacology and Experimental Therapeutics. 288: 699-709. PMID 9918578  1
1997 Kuczenski R, Segal DS, Todd PK. Behavioral sensitization and extracellular dopamine responses to amphetamine after various treatments. Psychopharmacology. 134: 221-9. PMID 9438672 DOI: 10.1007/s002130050445  1
1997 Shilling PD, Kelsoe JR, Segal DS. Dopamine transporter mRNA is up-regulated in the substantia nigra and the ventral tegmental area of amphetamine-sensitized rats. Neuroscience Letters. 236: 131-4. PMID 9406754 DOI: 10.1016/S0304-3940(97)00768-4  1
1997 Segal DS, Kuczenski R. Behavioral alterations induced by an escalating dose-binge pattern of cocaine administration. Behavioural Brain Research. 88: 251-60. PMID 9404634 DOI: 10.1016/S0166-4328(97)00067-3  1
1997 Kuczenski R, Melega WP, Cho AK, Segal DS. Extracellular dopamine and amphetamine after systemic amphetamine administration: comparison to the behavioral response. The Journal of Pharmacology and Experimental Therapeutics. 282: 591-6. PMID 9262319  1
1997 Segal DS, Kuczenski R. Repeated binge exposures to amphetamine and methamphetamine: behavioral and neurochemical characterization. The Journal of Pharmacology and Experimental Therapeutics. 282: 561-73. PMID 9262316  1
1997 Richtand NM, Kelsoe JR, Kuczenski R, Segal DS. Quantification of dopamine D1 and D2 receptor mRNA levels associated with the development of behavioral sensitization in amphetamine treated rats. Neurochemistry International. 31: 131-7. PMID 9185173 DOI: 10.1016/S0197-0186(96)00097-6  1
1997 Kuczenski R, Segal DS. An escalating dose/multiple high-dose binge pattern of amphetamine administration results in differential changes in the extracellular dopamine response profiles in caudate-putamen and nucleus accumbens. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 4441-7. PMID 9151761  1
1997 Kuczenski R, Segal DS. Effects of methylphenidate on extracellular dopamine, serotonin, and norepinephrine: comparison with amphetamine. Journal of Neurochemistry. 68: 2032-7. PMID 9109529  1
1997 Conti LH, Segal DS, Kuczenski R. Maintenance of amphetamine-induced stereotypy and locomotion requires ongoing dopamine receptor activation. Psychopharmacology. 130: 183-8. PMID 9106917 DOI: 10.1007/s002130050227  1
1997 Segal DS, Kuczenski R. An escalating dose "binge" model of amphetamine psychosis: behavioral and neurochemical characteristics. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 2551-66. PMID 9065515  1
1996 Garcia-Munoz M, Segal DS, Patino P, Young SJ, Kuczenski R, Groves PM. Amphetamine-induced changes in nigrostriatal terminal excitability are modified following repeated amphetamine pretreatment. Brain Research. 720: 131-8. PMID 8782905 DOI: 10.1016/0006-8993(96)00161-8  1
1996 Shilling PD, Kelsoe JR, Segal DS. Hippocampal glucocorticoid receptor mRNA is up-regulated by acute and down-regulated by chronic amphetamine treatment. Brain Research. Molecular Brain Research. 38: 156-60. PMID 8737679 DOI: 10.1016/0169-328X(96)00009-5  1
1995 Richtand NM, Kelsoe JR, Segal DS, Kuczenski R. Regional quantification of D1, D2, and D3 dopamine receptor mRNA in rat brain using a ribonuclease protection assay. Brain Research. Molecular Brain Research. 33: 97-103. PMID 8774950 DOI: 10.1016/0169-328X(95)00112-6  1
1995 Richtand NM, Kelsoe JR, Segal DS, Kuczenski R. Regional quantification of dopamine transporter mRNA in rat brain using a ribonuclease protection assay. Neuroscience Letters. 200: 73-6. PMID 8614566 DOI: 10.1016/0304-3940(95)12096-M  1
1995 Kuczenski R, Segal DS, Cho AK, Melega W. Hippocampus norepinephrine, caudate dopamine and serotonin, and behavioral responses to the stereoisomers of amphetamine and methamphetamine. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 1308-17. PMID 7869099  1
1995 Segal DS, Kuczenski R, Florin SM. Does dizocilpine (MK-801) selectively block the enhanced responsiveness to repeated amphetamine administration? Behavioral Neuroscience. 109: 532-46. PMID 7662163 DOI: 10.1037/0735-7044.109.3.532  1
1995 Florin SM, Kuczenski R, Segal DS. Effects of reserpine on extracellular caudate dopamine and hippocampus norepinephrine responses to amphetamine and cocaine: mechanistic and behavioral considerations. The Journal of Pharmacology and Experimental Therapeutics. 274: 231-41. PMID 7616403  1
1994 Florin SM, Kuczenski R, Segal DS. Regional extracellular norepinephrine responses to amphetamine and cocaine and effects of clonidine pretreatment. Brain Research. 654: 53-62. PMID 7982098 DOI: 10.1016/0006-8993(94)91570-9  1
1992 Britton KT, Segal DS, Kuczenski R, Hauger R. Dissociation between in vivo hippocampal norepinephrine response and behavioral/neuroendocrine responses to noise stress in rats. Brain Research. 574: 125-30. PMID 1638389 DOI: 10.1016/0006-8993(92)90808-M  1
1992 Kuczenski R, Segal DS. Regional norepinephrine response to amphetamine using dialysis: comparison with caudate dopamine. Synapse (New York, N.Y.). 11: 164-9. PMID 1626314 DOI: 10.1002/syn.890110210  1
1992 Segal DS, Kuczenski R. Repeated cocaine administration induces behavioral sensitization and corresponding decreased extracellular dopamine responses in caudate and accumbens. Brain Research. 577: 351-5. PMID 1606506 DOI: 10.1016/0006-8993(92)90297-M  1
1992 Manley LD, Kuczenski R, Segal DS, Young SJ, Groves PM. Effects of frequency and pattern of medial forebrain bundle stimulation on caudate dialysate dopamine and serotonin. Journal of Neurochemistry. 58: 1491-8. PMID 1548482  1
1992 Kuczenski R, Segal DS. Differential effects of amphetamine and dopamine uptake blockers (cocaine, nomifensine) on caudate and accumbens dialysate dopamine and 3-methoxytyramine. The Journal of Pharmacology and Experimental Therapeutics. 262: 1085-94. PMID 1527715  1
1992 Florin SM, Kuczenski R, Segal DS. Amphetamine-induced changes in behavior and caudate extracellular acetylcholine. Brain Research. 581: 53-8. PMID 1498671 DOI: 10.1016/0006-8993(92)90343-8  1
1992 Okuda C, Segal DS, Kuczenski R. Deprenyl alters behavior and caudate dopamine through an amphetamine-like action. Pharmacology, Biochemistry, and Behavior. 43: 1075-80. PMID 1475291 DOI: 10.1016/0091-3057(92)90484-W  1
1992 Segal DS, Kuczenski R, Okuda C. Clorgyline-induced increases in presynaptic DA: changes in the behavioral and neurochemical effects of amphetamine using in vivo microdialysis. Pharmacology, Biochemistry, and Behavior. 42: 421-9. PMID 1409775 DOI: 10.1016/0091-3057(92)90135-3  1
1992 Segal DS, Kuczenski R. In vivo microdialysis reveals a diminished amphetamine-induced DA response corresponding to behavioral sensitization produced by repeated amphetamine pretreatment. Brain Research. 571: 330-7. PMID 1377088 DOI: 10.1016/0006-8993(92)90672-V  1
1991 Kuczenski R, Segal DS, Aizenstein ML. Amphetamine, cocaine, and fencamfamine: relationship between locomotor and stereotypy response profiles and caudate and accumbens dopamine dynamics. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 11: 2703-12. PMID 1715389  1
1990 Kuczenski R, Segal DS, Manley LD. Apomorphine does not alter amphetamine-induced dopamine release measured in striatal dialysates. Journal of Neurochemistry. 54: 1492-9. PMID 2324735  1
1990 Gariano RF, Young SJ, Jeste DV, Segal DS, Groves PM. Effects of long-term administration of haloperidol on electrophysiologic properties of rat mesencephalic neurons. The Journal of Pharmacology and Experimental Therapeutics. 255: 108-13. PMID 2213545  1
1990 Kuczenski R, Segal DS. In vivo measures of monoamines during amphetamine-induced behaviors in rats. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 14: S37-50. PMID 2097672 DOI: 10.1016/0278-5846(90)90085-U  1
1990 Aizenstein ML, Segal DS, Kuczenski R. Repeated amphetamine and fencamfamine: sensitization and reciprocal cross-sensitization. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 3: 283-90. PMID 1976010  1
1989 Ryan LJ, Young SJ, Segal DS, Groves PM. Antidromically identified striatonigral projection neurons in the chronically implanted behaving rat: relations of cell firing to amphetamine-induced behaviors. Behavioral Neuroscience. 103: 3-14. PMID 2923676 DOI: 10.1037/0735-7044.103.1.3  1
1989 Irwin MR, Segal DS, Hauger RL, Smith TL. Individual behavioral and neuroendocrine differences in responsiveness to audiogenic stress. Pharmacology, Biochemistry, and Behavior. 32: 913-7. PMID 2798540 DOI: 10.1016/0091-3057(89)90058-0  1
1989 Callaway CW, Kuczenski R, Segal DS. Reserpine enhances amphetamine stereotypies without increasing amphetamine-induced changes in striatal dialysate dopamine. Brain Research. 505: 83-90. PMID 2611681 DOI: 10.1016/0006-8993(89)90118-2  1
1989 Kuczenski R, Segal D. Concomitant characterization of behavioral and striatal neurotransmitter response to amphetamine using in vivo microdialysis Journal of Neuroscience. 9: 2051-2065. PMID 2566664  1
1989 Segal DS, Kuczenski R, Swick D. Audiogenic stress response: behavioral characteristics and underlying monoamine mechanisms. Journal of Neural Transmission. 75: 31-50. PMID 2537372 DOI: 10.1007/BF01250642  1
1987 Geyer MA, Russo PV, Segal DS, Kuczenski R. Effects of apomorphine and amphetamine on patterns of locomotor and investigatory behavior in rats. Pharmacology, Biochemistry, and Behavior. 28: 393-9. PMID 3685075 DOI: 10.1016/0091-3057(87)90460-6  1
1987 Segal DS, Kuczenski R. Individual differences in responsiveness to single and repeated amphetamine administration: behavioral characteristics and neurochemical correlates. The Journal of Pharmacology and Experimental Therapeutics. 242: 917-26. PMID 3656119  1
1987 Gately PF, Segal DS, Geyer MA. Sequential changes in behavior induced by continuous infusions of amphetamine in rats. Psychopharmacology. 91: 217-20. PMID 3107035 DOI: 10.1007/BF00217066  1
1987 Barnett JV, Segal DS, Kuczenski R. Repeated amphetamine pretreatment alters the responsiveness of striatal dopamine-stimulated adenylate cyclase to amphetamine-induced desensitization. The Journal of Pharmacology and Experimental Therapeutics. 242: 40-7. PMID 2956412  1
1987 Segal DS, Kuczenski R. Behavioral and neurochemical characteristics of stimulant-induced augmentation. Psychopharmacology Bulletin. 23: 417-24. PMID 2893420  1
1987 Kuczenski R, Segal DS, Leith NJ, Applegate CD. Effects of amphetamine, methylphenidate, and apomorphine on regional brain serotonin and 5-hydroxyindole acetic acid. Psychopharmacology. 93: 329-35. PMID 2448842 DOI: 10.1007/BF00187252  1
1986 Gately PF, Segal DS, Geyer MA. The behavioral effects of depletions of brain serotonin induced by 5,7-dihydroxytryptamine vary with time after administration. Behavioral and Neural Biology. 45: 31-42. PMID 3954713 DOI: 10.1016/S0163-1047(86)80003-6  1
1986 Geyer MA, Masten VL, Segal DS. Behavioral effects of xylamine-induced depletions of brain norepinephrine: interaction with amphetamine. Behavioural Brain Research. 21: 55-64. PMID 3741596 DOI: 10.1016/0166-4328(86)90060-4  1
1986 Greenberg BD, Segal DS. Evidence for multiple opiate receptor involvement in different phencyclidine-induced unconditioned behaviors in rats. Psychopharmacology. 88: 44-53. PMID 3003779 DOI: 10.1007/BF00310511  1
1985 Greenberg BD, Segal DS. Acute and chronic behavioral interactions between phencyclidine (PCP) and amphetamine: evidence for a dopaminergic role in some PCP-induced behaviors. Pharmacology, Biochemistry, and Behavior. 23: 99-105. PMID 4041046 DOI: 10.1016/0091-3057(85)90137-6  1
1985 Arnsten AF, Berridge C, Segal DS. Stress produces opioid-like effects on investigatory behavior. Pharmacology, Biochemistry, and Behavior. 22: 803-9. PMID 4011639 DOI: 10.1016/0091-3057(85)90531-3  1
1985 Gately PF, Poon SL, Segal DS, Geyer MA. Depletion of brain serotonin by 5,7-dihydroxytryptamine alters the response to amphetamine and the habituation of locomotor activity in rats. Psychopharmacology. 87: 400-5. PMID 3936096 DOI: 10.1007/BF00432502  1
1985 Gately PF, Segal DS, Geyer MA. Depletion of brain serotonin by 5,7-dihydroxytryptamine produces different behavioral responses when measured 3 or 11 days after lesioning Federation Proceedings. 44: 3632.  1
1984 Russell JW, Greenberg BD, Segal DS. The effects of phencyclidine on spontaneous aggressive behavior in the rat. Biological Psychiatry. 19: 195-202. PMID 6538800  1
1984 Arnsten AF, Neville HJ, Hillyard SA, Janowsky DS, Segal DS. Naloxone increases electrophysiological measures of selective information processing in humans. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 4: 2912-9. PMID 6502211  1
1984 Geyer MA, Segal DS, Greenberg BD. Increased startle responding in rats treated with phencyclidine. Neurobehavioral Toxicology and Teratology. 6: 161-4. PMID 6472561  1
1984 Groves PM, Segal DS. Psychobiological foundations of behaviors induced by amphetamines. Nida Research Monograph. 54: 356-66. PMID 6099879  1
1983 Arnsten AF, Segal DS, Neville HJ, Hillyard SA, Janowsky DS, Judd LL, Bloom FE. Naloxone augments electrophysiological signs of selective attention in man. Nature. 304: 725-7. PMID 6888538 DOI: 10.1038/304725a0  1
1983 Judd LL, Risch SC, Segal DS, Janowsky DS, Huey LY. Behavioral and neuroendocrine effects of opioid receptor agonists in psychopathologic states. The Psychiatric Clinics of North America. 6: 393-402. PMID 6359090  1
1983 Janowsky DS, Judd LL, Huey LY, Risch SC, Segal DS. Behavioral effects of opioid receptor antagonists in psychopathologic states. The Psychiatric Clinics of North America. 6: 403-14. PMID 6316300  1
1982 Judd LL, Risch SC, Parker DC, Janowsky DS, Segal DS, Huey LY. Blunted prolactin response. A neuroendocrine abnormality manifested by depressed patients. Archives of General Psychiatry. 39: 1413-6. PMID 7149902 DOI: 10.1001/archpsyc.1982.04290120045009  1
1982 Judd LL, Parker DC, Janowsky DS, Segal DS, Risch SC, Huey LY. The effect of methadone on the behavioral and neuroendocrine responses of manic patients. Psychiatry Research. 7: 163-70. PMID 6959168 DOI: 10.1016/0165-1781(92)90089-L  1
1982 Kuczenski R, Segal DS, Weinberger SB, Browne RG. Evidence that a behavioral augmentation following repeated amphetamine administration does not involve peripheral mechanisms. Pharmacology, Biochemistry, and Behavior. 17: 547-53. PMID 6890688 DOI: 10.1016/0091-3057(82)90317-3  1
1982 Sibley DR, Weinberger S, Segal DS, Creese I. Multiple daily amphetamine administration decreases both [3H]agonist and [3H]antagonist dopamine receptor binding. Experientia. 38: 1224-5. PMID 6890464 DOI: 10.1007/BF01959753  1
1982 Creese I, Kuczenski R, Segal D. Lack of behavioral evidence for dopamine autoreceptor subsensitivity after acute electroconvulsive shock. Pharmacology, Biochemistry, and Behavior. 17: 375-6. PMID 6291070 DOI: 10.1016/0091-3057(82)90096-X  1
1981 Judd LL, Janowsky DS, Segal DS, Parker DC, Huey LY. Behavioral effects of methadone in schizophrenic patients. The American Journal of Psychiatry. 138: 243-5. PMID 7457649  1
1981 Arnsten AF, Segal DS, Loughlin SE, Roberts DC. Evidence for an interaction of opioid and noradrenergic locus coeruleus systems in the regulation of environmental stimulus-directed behavior. Brain Research. 222: 351-63. PMID 7284783 DOI: 10.1016/0006-8993(81)91038-6  1
1981 Segal DS, Geyer MA, Schuckit MA. Stimulant-induced psychosis: an evaluation of animal methods. Essays in Neurochemistry and Neuropharmacology. 5: 95-129. PMID 6112147  1
1981 Judd LL, Janowsky DS, Segal DS, Huey LY. In Reply Archives of General Psychiatry. 38: 845. DOI: 10.1001/archpsyc.1981.01780320125021  1
1980 Segal DS, Weinberger SB, Cahill J, McCunney SJ. Multiple daily amphetamine administration: behavioral and neurochemical alterations. Science (New York, N.Y.). 207: 904-7. PMID 17729873 DOI: 10.1126/science.207.4433.904  0.48
1980 Judd LL, Janowsky DS, Segal DS, Huey LY. Naloxone-induced behavioral and physiological effects in normal and manic subjects. Archives of General Psychiatry. 37: 583-6. PMID 7377916 DOI: 10.1001/archpsyc.1980.01780180097012  1
1980 Rebec GV, Segal DS. Apparent tolerance to some aspects of amphetamine stereotypy with long-term treatment. Pharmacology, Biochemistry, and Behavior. 13: 793-7. PMID 7193874 DOI: 10.1016/0091-3057(80)90209-9  1
1980 Segal DS, Weinberger SB, Cahill J, McCunney SJ. Multiple daily amphetamine administration: behavioral and neurochemical alterations. Science (New York, N.Y.). 207: 905-7. PMID 7188815  1
1980 Browne RG, Segal DS. Alterations in beta-endorphin-induced locomotor activity in morphine-tolerant rats. Neuropharmacology. 19: 619-21. PMID 6250095 DOI: 10.1016/0028-3908(80)90035-0  1
1980 Browne RG, Segal DS. Behavioral activating effects of opiates and opioid peptides. Biological Psychiatry. 15: 77-86. PMID 6101965  1
1979 Arnsten AT, Segal DS. Naloxone alters locomotion and interaction with environmental stimuli. Life Sciences. 25: 1035-42. PMID 513946 DOI: 10.1016/0024-3205(79)90589-7  1
1979 Weinberger SB, Arnsten A, Segal DS. Des-tyrosine1-gamma-endorphin and haloperidol: behavioral and biochemical differentiation. Life Sciences. 24: 1637-43. PMID 481098 DOI: 10.1016/0024-3205(79)90246-7  1
1979 Rebec GV, Segal DS. Enhanced responsiveness to intraventricular infusion of amphetamine following its repeated systemic administration. Psychopharmacology. 62: 101-2. PMID 108743 DOI: 10.1007/BF00426043  1
1979 Browne RG, Derrington DC, Segal DS. Comparison of opiate- and opioid-peptide-induced immobility. Life Sciences. 24: 933-41. PMID 36533 DOI: 10.1016/0024-3205(79)90344-8  1
1978 Rebec GV, Segal DS. Dose-dependent biphasic alterations in the spontaneous activity of neurons in the rat neostriatum produced by d-amphetamine and methylphenidate. Brain Research. 150: 353-66. PMID 567085 DOI: 10.1016/0006-8993(78)90286-X  1
1978 Skolnick P, Daly JW, Segal DS. Neurochemical and behavioral effects of clonidine and related imidazolines: interaction with alpha-adrenoceptors. European Journal of Pharmacology. 47: 451-5. PMID 204500 DOI: 10.1016/0014-2999(78)90126-7  1
1978 Segal DS. Some considerations regarding the characterization and interpretation of neuropeptide-induced behavioral changes. Neurosciences Research Program Bulletin. 16: 510-20. PMID 35764  1
1977 Segal DS, Browne RG, Bloom F, Ling N, Guillemin R. beta-Endorphin: endogenous opiate or neuroleptic? Science (New York, N.Y.). 198: 411-4. PMID 910136  1
1977 Janowsky DS, Segal DS, Bloom F, Abrams A, Guillemin R. Lack of effect on naloxone on schizophrenic symptoms. The American Journal of Psychiatry. 134: 926-7. PMID 879360  1
1977 Liebman J, Segal DS. Differential effects of morphine and D-amphetamine on self-stimulation from closely adjacent regions in rat midbrain. Brain Research. 136: 103-17. PMID 589437 DOI: 10.1016/0006-8993(77)90135-4  1
1977 Browne RG, Segal DS. Metabolic and experimental factors in the behavioral response to repeated amphetamine. Pharmacology, Biochemistry, and Behavior. 6: 545-52. PMID 561406 DOI: 10.1016/0091-3057(77)90115-0  1
1977 Janowsky DS, Segal DS, Abrams A, Bloom F, Guillemin R. Negative naloxone effects in schizophrenic patients. Psychopharmacology. 53: 295-7. PMID 19807 DOI: 10.1007/BF00492367  1
1976 Geyer MA, Puerto A, Menkes DB, Segal DS, Mandell AJ. Behavioral studies following lesions of the mesolimbic and mesostriatal serotonergic pathways. Brain Research. 106: 257-69. PMID 1276871 DOI: 10.1016/0006-8993(76)91023-4  1
1976 Liebman JM, Segal DS. Lithium differentially antagonises self-stimulation facilitated by morphine and (+)-amphetamine. Nature. 260: 161-3. PMID 1256558  1
1976 Hadorn D, Mandell AJ, Segal DS. The effects of chronic mescaline administration on operant behavior in the pigeon. Behavioral Biology. 17: 403-9. PMID 971192 DOI: 10.1016/S0091-6773(76)90766-5  1
1976 Segal DS, Geyer MA. Pre- and post-junctional supersensitivity: differentiation by intraventricular infusions of norepinephrine and methoxamine. Psychopharmacology. 50: 145-8. PMID 188061 DOI: 10.1007/BF00430483  1
1976 Liebman JM, Segal DS. Lack of tolerance or sensitization to the effects of chronic d-amphetamine on substantia nigra self-stimulation. Behavioral Biology. 16: 211-20. PMID 176995 DOI: 10.1016/S0091-6773(76)91324-9  1
1976 Segal DS. Differential effects of para-chlorophenylalanine on amphetamine-induced locomotion and stereotypy. Brain Research. 116: 267-76. PMID 135600 DOI: 10.1016/0006-8993(76)90904-5  1
1976 Browne RG, Segal DS. Environmental influences on the behavioral response to acute and chronic amphetamine administration Federation Proceedings. 35: No.3191.  1
1975 Segal DS. Behavioral and neurochemical correlates of repeated d-amphetamine administration. Advances in Biochemical Psychopharmacology. 13: 247-62. PMID 1171583  1
1975 Segal DS. Behavioral characterization of d- and l-amphetamine: neurochemical implications. Science (New York, N.Y.). 190: 475-7. PMID 1166317  1
1975 Segal DS, Geyer MA, Weiner BE. Strain differences during intraventricular infusion of norepinephrine: possible role of receptor sensitivity. Science (New York, N.Y.). 189: 301-3. PMID 1145205  1
1975 Kuczenski R, Segal DS. Differential effects of D- and L-amphetamine and methylphenidate on rat striatal dopamine biosynthesis. European Journal of Pharmacology. 30: 244-51. PMID 1126362 DOI: 10.1016/0014-2999(75)90106-5  1
1975 Kuczenski R, Segal DS, Mandell AJ. Regional and subcellular distribution and kinetic properties of rat brain choline acetyltransferase--some functional considerations. Journal of Neurochemistry. 24: 39-45. PMID 1110366  1
1975 Schlehuber CJ, Segal DS, Spooner CE. Alterations in neostriatum tyrosine hydroxylase activity and behavior induced by electrical stimulation of the substantia nigra. Brain Research. 91: 341-7. PMID 240483 DOI: 10.1016/0006-8993(75)90560-0  1
1975 Segal DS, Callaghan M, Mandell AJ. Alterations in behaviour and catecholamine biosynthesis induced by lithium. Nature. 254: 58-9. PMID 234597  1
1974 Segal DS, Mandell AJ. Long-term administration of d-amphetamine: progressive augmentation of motor activity and stereotypy. Pharmacology, Biochemistry, and Behavior. 2: 249-55. PMID 4857295 DOI: 10.1016/0091-3057(74)90060-4  1
1974 Segal DS, McAllister C, Geyer MA. Ventricular infusion of norepinephrine and amphetamine: direct versus indirect action. Pharmacology, Biochemistry, and Behavior. 2: 79-86. PMID 4857225 DOI: 10.1016/0091-3057(74)90138-5  1
1974 Geyer MA, Segal DS. Shock-induced aggression: opposite effects of intraventricularly infused dopamine and norepinephrine. Behavioral Biology. 10: 99-104. PMID 4856062 DOI: 10.1016/S0091-6773(74)91704-0  1
1974 Kuczenski R, Segal DS. Intrasynaptosomal conversion of tyrosine to dopamine as an index of brain catecholamine biosynthetic capacity. Journal of Neurochemistry. 22: 1039-44. PMID 4852547  1
1974 Groves PM, Rebec GV. The action of D-amphetamine on spontaneous activity in the caudate nucleus and reticular formation of the rat. Behavioral Biology. 11: 33-47. PMID 4364308 DOI: 10.1016/S0091-6773(74)90158-8  1
1974 Mandell AJ, Segal DS, Kuczenski R. Proceedings: Metabolic adaptation to antidepressant drugs--a neurochemical paradox. Psychopharmacology Bulletin. 10: 53-4. PMID 4154475  1
1974 Segal DS, Kuczenski R, Mandell AJ. Theoretical implications of drug-induced adaptive regulation for a biogenic amine hypothesis of affective disorder. Biological Psychiatry. 9: 147-59. PMID 4154114  1
1974 Segal DS, Kuczenski R. Tyrosine hydroxylase activity: regional and subcellular distribution in the brain. Brain Research. 68: 261-6. PMID 4151196 DOI: 10.1016/0006-8993(74)90395-3  1
1973 Geyer MA, Segal DS. Differential effects of reserpine and alpha-methyl-P-tyrosine on norepinephrine and dopamine induced behavioral activity. Psychopharmacologia. 29: 131-40. PMID 4709837 DOI: 10.1007/BF00422645  1
1973 Segal DS, Knapp S, Kuczenski RT, Mandell AJ. The effects of environmental isolation on behavior and regional rat brain tyrosine hydroxylase and tryptophan hydroxylase activities. Behavioral Biology. 8: 47-53. PMID 4144216 DOI: 10.1016/S0091-6773(73)80005-7  1
1972 Geyer MA, Segal DS, Mandell AJ. Effect of intraventricular infusion of dopamine and norepinephrine on motor activity. Physiology & Behavior. 8: 653-8. PMID 5038135 DOI: 10.1016/0031-9384(72)90090-X  1
1972 Mandell AJ, Knapp S, Kuczenski RT, Segal DS. Methamphetamine-induced alteration in the physical state of rat caudate tyrosine hydroxylase. Biochemical Pharmacology. 21: 2737-50. PMID 4405233 DOI: 10.1016/0006-2952(72)90022-6  1
1972 Segal DS, Kuczenski RT, Mandell AJ. Strain differences in behavior and brain tyrosine hydroxylase activity. Behavioral Biology. 7: 75-81. PMID 4402928 DOI: 10.1016/S0091-6773(72)80190-1  1
1972 Sullivan JL, Segal DS, Kuczenski RT, Mandell AJ. Propranolol-induced rapid activation of rat striatal tyrosine hydroxylase concomitant with behavioral depression. Biological Psychiatry. 4: 193-203. PMID 4402871  1
1972 Emlen W, Segal DS, Mandell AJ. Thyroid state: effects on pre- and postsynaptic central noradrenergic mechanisms. Science (New York, N.Y.). 175: 79-82. PMID 4400216  1
1971 Segal DS, Sullivan JL, Kuczenski RT, Mandell AJ. Effects of long-term reserpine treatment on brain tyrosine hydroxylase and behavioral activity. Science (New York, N.Y.). 173: 847-9. PMID 5572177  1
1971 Segal DS, Squire LR, Barondes SH. Cycloheximide: its effects on activity are dissociable from its effects on memory. Science (New York, N.Y.). 172: 82-4. PMID 5546289  1
1970 Segal DS, Mandell AJ. Behavioral activation of rats during intraventricular infusion of norepinephrine. Proceedings of the National Academy of Sciences of the United States of America. 66: 289-93. PMID 5271164  1
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