Ray Kelleher - Publications

Affiliations: 
Harvard Medical School, Boston, MA, United States 

30 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Kelleher RJ, Shen J. Presenilin-1 mutations and Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 28082723 DOI: 10.1073/pnas.1619574114  0.32
2016 Xia D, Kelleher RJ, Shen J. Loss of Aβ43 Production Caused by Presenilin-1 Mutations in the Knockin Mouse Brain. Neuron. 90: 417-422. PMID 27100200 DOI: 10.1016/j.neuron.2016.03.009  1
2015 Xia D, Watanabe H, Wu B, Lee SH, Li Y, Tsvetkov E, Bolshakov VY, Shen J, Kelleher RJ. Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's disease. Neuron. 85: 967-81. PMID 25741723 DOI: 10.1016/j.neuron.2015.02.010  1
2014 Grishchuk Y, Sri S, Rudinskiy N, Ma W, Stember KG, Cottle MW, Sapp E, Difiglia M, Muzikansky A, Betensky RA, Wong AM, Bacskai BJ, Hyman BT, Kelleher RJ, Cooper JD, et al. Behavioral deficits, early gliosis, dysmyelination and synaptic dysfunction in a mouse model of mucolipidosis IV. Acta Neuropathologica Communications. 2: 133. PMID 25200117 DOI: 10.1186/s40478-014-0133-7  1
2013 Heilig EA, Gutti U, Tai T, Shen J, Kelleher RJ. Trans-dominant negative effects of pathogenic PSEN1 mutations on γ-secretase activity and Aβ production. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 11606-17. PMID 23843529 DOI: 10.1523/JNEUROSCI.0954-13.2013  1
2012 Kelleher RJ, Geigenmüller U, Hovhannisyan H, Trautman E, Pinard R, Rathmell B, Carpenter R, Margulies D. High-throughput sequencing of mGluR signaling pathway genes reveals enrichment of rare variants in autism. Plos One. 7: e35003. PMID 22558107 DOI: 10.1371/journal.pone.0035003  1
2012 Watanabe H, Xia D, Kanekiyo T, Kelleher RJ, Shen J. Familial frontotemporal dementia-associated presenilin-1 c.548G>T mutation causes decreased mRNA expression and reduced presenilin function in knock-in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 5085-96. PMID 22496554 DOI: 10.1523/JNEUROSCI.0317-12.2012  1
2011 Anguera MC, Ma W, Clift D, Namekawa S, Kelleher RJ, Lee JT. Tsx produces a long noncoding RNA and has general functions in the germline, stem cells, and brain. Plos Genetics. 7: e1002248. PMID 21912526 DOI: 10.1371/journal.pgen.1002248  1
2010 Kelleher RJ, Shen J. Genetics. Gamma-secretase and human disease. Science (New York, N.Y.). 330: 1055-6. PMID 21097925 DOI: 10.1126/science.1198668  1
2010 Heilig EA, Xia W, Shen J, Kelleher RJ. A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity. The Journal of Biological Chemistry. 285: 22350-9. PMID 20460383 DOI: 10.1074/jbc.M110.116962  1
2010 Tong Y, Yamaguchi H, Giaime E, Boyle S, Kopan R, Kelleher RJ, Shen J. Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice. Proceedings of the National Academy of Sciences of the United States of America. 107: 9879-84. PMID 20457918 DOI: 10.1073/pnas.1004676107  1
2010 Wines-Samuelson M, Schulte EC, Smith MJ, Aoki C, Liu X, Kelleher RJ, Shen J. Characterization of age-dependent and progressive cortical neuronal degeneration in presenilin conditional mutant mice. Plos One. 5: e10195. PMID 20419112 DOI: 10.1371/journal.pone.0010195  1
2009 Watanabe H, Smith MJ, Heilig E, Beglopoulos V, Kelleher RJ, Shen J. Indirect regulation of presenilins in CREB-mediated transcription. The Journal of Biological Chemistry. 284: 13705-13. PMID 19289467 DOI: 10.1074/jbc.M809168200  1
2008 Kelleher RJ, Bear MF. The autistic neuron: troubled translation? Cell. 135: 401-6. PMID 18984149 DOI: 10.1016/j.cell.2008.10.017  1
2007 Shen J, Kelleher RJ. The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism. Proceedings of the National Academy of Sciences of the United States of America. 104: 403-9. PMID 17197420 DOI: 10.1073/pnas.0608332104  1
2006 Govindarajan A, Kelleher RJ, Tonegawa S. A clustered plasticity model of long-term memory engrams. Nature Reviews. Neuroscience. 7: 575-83. PMID 16791146 DOI: 10.1038/nrn1937  1
2004 Kelleher RJ, Govindarajan A, Tonegawa S. Translational regulatory mechanisms in persistent forms of synaptic plasticity. Neuron. 44: 59-73. PMID 15450160 DOI: 10.1016/j.neuron.2004.09.013  1
2004 Saura CA, Choi SY, Beglopoulos V, Malkani S, Zhang D, Shankaranarayana Rao BS, Chattarji S, Kelleher RJ, Kandel ER, Duff K, Kirkwood A, Shen J. Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Neuron. 42: 23-36. PMID 15066262 DOI: 10.1016/S0896-6273(04)00182-5  1
2004 Kelleher RJ, Govindarajan A, Jung HY, Kang H, Tonegawa S. Translational control by MAPK signaling in long-term synaptic plasticity and memory. Cell. 116: 467-79. PMID 15016380 DOI: 10.1016/S0092-8674(04)00115-1  1
1994 Kim TK, Hashimoto S, Kelleher RJ, Flanagan PM, Kornberg RD, Horikoshi M, Roeder RG. Effects of activation-defective TBP mutations on transcription initiation in yeast. Nature. 369: 252-5. PMID 8183347 DOI: 10.1038/369252a0  1
1992 Flanagan PM, Kelleher RJ, Tschochner H, Sayre MH, Kornberg RD. Simple derivation of TFIID-dependent RNA polymerase II transcription systems from Schizosaccharomyces pombe and other organisms, and factors required for transcriptional activation. Proceedings of the National Academy of Sciences of the United States of America. 89: 7659-63. PMID 1502179 DOI: 10.1073/pnas.89.16.7659  1
1992 Kelleher RJ, Flanagan PM, Chasman DI, Ponticelli AS, Struhl K, Kornberg RD. Yeast and human TFIIDs are interchangeable for the response to acidic transcriptional activators in vitro. Genes & Development. 6: 296-303. PMID 1310667 DOI: 10.1101/gad.6.2.296  1
1991 Flanagan PM, Kelleher RJ, Sayre MH, Tschochner H, Kornberg RD. A mediator required for activation of RNA polymerase II transcription in vitro. Nature. 350: 436-8. PMID 2011193 DOI: 10.1038/350436a0  1
1991 Lue NF, Flanagan PM, Kelleher RJ, Edwards AM, Kornberg RD. RNA polymerase II transcription in vitro. Methods in Enzymology. 194: 545-50. PMID 2005807 DOI: 10.1016/0076-6879(91)94041-A  1
1990 Flanagan PM, Kelleher RJ, Feaver WJ, Lue NF, LaPointe JW, Kornberg RD. Resolution of factors required for the initiation of transcription by yeast RNA polymerase II. The Journal of Biological Chemistry. 265: 11105-7. PMID 2193032  1
1990 Kelleher RJ, Flanagan PM, Kornberg RD. A novel mediator between activator proteins and the RNA polymerase II transcription apparatus. Cell. 61: 1209-15. PMID 2163759 DOI: 10.1016/0092-8674(90)90685-8  1
1986 Ellison MJ, Feigon J, Kelleher RJ, Wang AH, Habener JF, Rich A. An assessment of the Z-DNA forming potential of alternating dA-dT stretches in supercoiled plasmids. Biochemistry. 25: 3648-55. PMID 3718951  1
1986 Kelleher RJ, Ellison MJ, Ho PS, Rich A. Competitive behavior of multiple, discrete B-Z transitions in supercoiled DNA. Proceedings of the National Academy of Sciences of the United States of America. 83: 6342-6. PMID 3462699  1
1985 Ellison MJ, Kelleher RJ, Wang AH, Habener JF, Rich A. Sequence-dependent energetics of the B-Z transition in supercoiled DNA containing nonalternating purine-pyrimidine sequences. Proceedings of the National Academy of Sciences of the United States of America. 82: 8320-4. PMID 3866225  1
1985 Ellison MJ, Kelleher RJ, Rich A. Thermal regulation of beta-galactosidase synthesis using anti-sense RNA directed against the coding portion of the mRNA. The Journal of Biological Chemistry. 260: 9085-7. PMID 2410407  1
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