Year |
Citation |
Score |
2020 |
LaMarche MJ, Acker MG, Argintaru A, Bauer D, Boisclair J, Chan H, Chen C, Chen YP, Chen Z, Deng Z, Doré M, Dunstan D, Fan J, Fekkes P, Firestone B, et al. Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer. Journal of Medicinal Chemistry. PMID 32910655 DOI: 10.1021/Acs.Jmedchem.0C01170 |
0.333 |
|
2016 |
LaMarche MJ, Leeds JA, Brewer J, Dean K, Ding J, Dzink-Fox J, Gamber G, Jain A, Kerrigan R, Krastel P, Lee K, Lombardo F, McKenney D, Neckermann G, Osborne CS, et al. Antibacterial and Solubility Optimization of Thiomuracin A. Journal of Medicinal Chemistry. PMID 27355833 DOI: 10.1021/acs.jmedchem.6b00726 |
0.362 |
|
2013 |
LaMarche MJ, Leeds JA, Dzink-Fox J, Gangl E, Krastel P, Neckermann G, Palestrant D, Patane MA, Rann EM, Tiamfook S, Yu D. Correction to Antibiotic Optimization and Chemical Structure Stabilization of Thiomuracin A Journal of Medicinal Chemistry. 56: 1360-1360. DOI: 10.1021/Jm4000402 |
0.339 |
|
2012 |
LaMarche MJ, Leeds JA, Dzink-Fox J, Gangl E, Krastel P, Neckermann G, Palestrant D, Patane MA, Rann EM, Tiamfook S, Yu D. Antibiotic optimization and chemical structure stabilization of thiomuracin A. Journal of Medicinal Chemistry. 55: 6934-41. PMID 22812377 DOI: 10.1021/jm300783c |
0.424 |
|
2012 |
Trzasko A, Leeds JA, Praestgaard J, Lamarche MJ, McKenney D. Efficacy of LFF571 in a hamster model of Clostridium difficile infection. Antimicrobial Agents and Chemotherapy. 56: 4459-62. PMID 22644020 DOI: 10.1128/Aac.06355-11 |
0.315 |
|
2012 |
LaMarche MJ, Leeds JA, Amaral A, Brewer JT, Bushell SM, Deng G, Dewhurst JM, Ding J, Dzink-Fox J, Gamber G, Jain A, Lee K, Lee L, Lister T, McKenney D, et al. Discovery of LFF571: an investigational agent for Clostridium difficile infection. Journal of Medicinal Chemistry. 55: 2376-87. PMID 22315981 DOI: 10.1021/Jm201685H |
0.305 |
|
2011 |
LaMarche MJ, Leeds JA, Amaral K, Brewer JT, Bushell SM, Dewhurst JM, Dzink-Fox J, Gangl E, Goldovitz J, Jain A, Mullin S, Neckermann G, Osborne C, Palestrant D, Patane MA, et al. Antibacterial optimization of 4-aminothiazolyl analogues of the natural product GE2270 A: identification of the cycloalkylcarboxylic acids. Journal of Medicinal Chemistry. 54: 8099-109. PMID 21999529 DOI: 10.1021/Jm200938F |
0.302 |
|
2011 |
Leeds JA, LaMarche MJ, Brewer JT, Bushell SM, Deng G, Dewhurst JM, Dzink-Fox J, Gangl E, Jain A, Lee L, Lilly M, Manni K, Mullin S, Neckermann G, Osborne C, et al. In vitro and in vivo activities of novel, semisynthetic thiopeptide inhibitors of bacterial elongation factor Tu. Antimicrobial Agents and Chemotherapy. 55: 5277-83. PMID 21825297 DOI: 10.1128/Aac.00582-11 |
0.345 |
|
2011 |
LaMarche MJ, Leeds JA, Dzink-Fox J, Mullin S, Patane MA, Rann EM, Tiamfook S. 4-Aminothiazolyl analogs of GE2270 A: design, synthesis and evaluation of imidazole analogs. Bioorganic & Medicinal Chemistry Letters. 21: 3210-5. PMID 21550238 DOI: 10.1016/j.bmcl.2011.04.048 |
0.379 |
|
2011 |
LaMarche MJ, Leeds JA, Dzink-Fox J, Gunderson K, Krastel P, Memmert K, Patane MA, Rann EM, Schmitt E, Tiamfook S, Wang B. 4-Aminothiazolyl analogues of GE2270 A: antibacterial lead finding. Journal of Medicinal Chemistry. 54: 2517-21. PMID 21405087 DOI: 10.1021/jm101602q |
0.422 |
|
2005 |
Smith AB, Freeze BS, LaMarche MJ, Sager J, Kinzler KW, Vogelstein B. Discodermolide analogues as the chemical component of combination bacteriolytic therapy. Bioorganic & Medicinal Chemistry Letters. 15: 3623-6. PMID 15979874 DOI: 10.1016/J.Bmcl.2005.05.068 |
0.578 |
|
2005 |
Smith AB, Freeze BS, Lamarche MJ, Hirose T, Brouard I, Xian M, Sundermann KF, Shaw SJ, Burlingame MA, Horwitz SB, Myles DC. Design, synthesis, and evaluation of analogues of (+)-14-normethyldiscodermolide. Organic Letters. 7: 315-8. PMID 15646986 DOI: 10.1021/Ol0476873 |
0.615 |
|
2005 |
Smith AB, Freeze BS, Lamarche MJ, Hirose T, Brouard I, Rucker PV, Xian M, Sundermann KF, Shaw SJ, Burlingame MA, Horwitz SB, Myles DC. Design, synthesis, and evaluation of carbamate-substituted analogues of (+)-discodermolide. Organic Letters. 7: 311-4. PMID 15646985 DOI: 10.1021/Ol047686A |
0.619 |
|
2004 |
Burlingame MA, Shaw SJ, Sundermann KF, Zhang D, Petryka J, Mendoza E, Liu F, Myles DC, LaMarche MJ, Hirose T, Scott Freeze B, Smith AB. Design, synthesis and cytotoxicity of 7-deoxy aryl discodermolide analogues. Bioorganic & Medicinal Chemistry Letters. 14: 2335-8. PMID 15081036 DOI: 10.1016/J.Bmcl.2004.01.102 |
0.544 |
|
2001 |
Martello LA, LaMarche MJ, He L, Beauchamp TJ, Smith AB, Horwitz SB. The relationship between Taxol and (+)-discodermolide: synthetic analogs and modeling studies. Chemistry & Biology. 8: 843-55. PMID 11564553 DOI: 10.1016/S1074-5521(01)00055-2 |
0.476 |
|
2000 |
Smith AB, Beauchamp TJ, Lamarche MJ, Kaufman MD, Qiu Y, Arimoto H, Jones DR, Kobayashi K. Evolution of a gram-scale synthesis of (+)-discodermolide Journal of the American Chemical Society. 122: 8654-8664. DOI: 10.1021/Ja0015287 |
0.337 |
|
1999 |
Smith AB, Kaufman MD, Beauchamp TJ, LaMarche MJ, Arimoto H. Gram-scale synthesis of (+)-discodermolide. Organic Letters. 1: 1823-6. PMID 10836041 DOI: 10.1021/Ol9910870 |
0.336 |
|
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