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Dionicio R. Siegel, Ph.D. - Publications

Affiliations: 
2003 Harvard University, Cambridge, MA, United States 
Area:
synthesis of natural products
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47 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Konduri S, Schweer J, Siegel D. Short Synthesis of a Broadly Reactive, Cell Permeable Serine Hydrolase Fluorophosphonate-Alkyne Probe. Bioorganic & Medicinal Chemistry Letters. 129434. PMID 37557924 DOI: 10.1016/j.bmcl.2023.129434  0.377
2020 Konduri S, Prashanth J, Krishna VS, Sriram D, Behera JN, Siegel D, Rao KP. Design and Synthesis of Purine Connected Piperazine Derivatives as Novel Inhibitors of Mycobacterium tuberculosis. Bioorganic & Medicinal Chemistry Letters. 127512. PMID 32871269 DOI: 10.1016/J.Bmcl.2020.127512  0.372
2020 Christy MP, Johnson T, McNerlin CD, Woodard J, Nelson AT, Lim B, Hamilton TL, Freiberg KM, Siegel D. Total Synthesis of Micrococcin P1 through Scalable Thiazole Forming Reactions of Cysteine Derivatives and Nitriles. Organic Letters. PMID 32134277 DOI: 10.1021/Acs.Orglett.0C00202  0.422
2020 Quinn RA, Melnik AV, Vrbanac A, Fu T, Patras KA, Christy MP, Bodai Z, Belda-Ferre P, Tripathi A, Chung LK, Downes M, Welch RD, Quinn M, Humphrey G, Panitchpakdi M, ... ... Siegel D, et al. Global chemical effects of the microbiome include new bile-acid conjugations. Nature. PMID 32103176 DOI: 10.1038/S41586-020-2047-9  0.346
2020 Santoro A, Zhou P, Zhu Y, Peroni OD, Nelson AT, Siegel D, Kahn B. 1832-P: Palmitic Acid Esters of Hydroxy Stearic Acids Reduce Endogenous Glucose Production through GPR43 Activation Diabetes. 69. DOI: 10.2337/Db20-1832-P  0.302
2019 Wang H, Kolar MJ, Chang T, Rizo J, Konduri S, McNerlin C, Saghatelian A, Siegel D. Stereochemistry of Linoleic Acid Esters of Hydroxy Linoleic Acids. Organic Letters. PMID 31545060 DOI: 10.1021/Acs.Orglett.9B03054  0.317
2019 Wang H, Chang T, Konduri S, Huang J, Saghatelian A, Siegel D. Synthesis of chemically edited derivatives of the endogenous regulator of inflammation 9-PAHSA. The Journal of Antibiotics. PMID 30988370 DOI: 10.1038/S41429-019-0180-1  0.349
2018 Kolar MJ, Nelson AT, Chang T, Ertunc ME, Christy MP, Ohlsson L, Härröd M, Kahn BB, Siegel D, Saghatelian A. Faster Protocol for Endogenous Fatty Acid Esters of Hydroxy Fatty Acid (FAHFA) Measurements. Analytical Chemistry. PMID 29578702 DOI: 10.1021/Acs.Analchem.8B00503  0.302
2018 Eliasen AM, Chin MR, Axelrod AJ, Abagyan R, Siegel D. Cascade reactions leading to the mechanism of action of vinaxanthone and xanthofulvin, natural products that drive nerve repair Tetrahedron. 74: 3238-3245. DOI: 10.1016/J.Tet.2018.02.068  0.778
2017 Johnson TC, Siegel D. Directing Stem Cell Fate: The Synthetic Natural Product Connection. Chemical Reviews. PMID 28771328 DOI: 10.1021/Acs.Chemrev.7B00015  0.332
2017 Johnson TC, Chin MR, Siegel D. Synthetic Route Development for the Laboratory Preparation of Eupalinilide E. The Journal of Organic Chemistry. PMID 28440078 DOI: 10.1021/Acs.Joc.7B00266  0.449
2017 Nelson AT, Kolar MJ, Chu Q, Syed I, Kahn BB, Saghatelian A, Siegel D. Stereochemistry of Endogenous Palmitic Acid Ester of 9-Hydroxystearic Acid and Relevance of Absolute Configuration to Regulation. Journal of the American Chemical Society. PMID 28350171 DOI: 10.1021/Jacs.7B01269  0.336
2016 Johnson TC, Chin MR, Han T, Shen JP, Rana TM, Siegel D. Synthesis of Eupalinilide E a Promoter of Human Hematopoietic Stem and Progenitor Cell Expansion. Journal of the American Chemical Society. PMID 27096704 DOI: 10.1021/Jacs.6B03055  0.42
2015 Eliasen AM, Christy M, Claussen KR, Besandre R, Thedford RP, Siegel D. Dearomatization Reactions Using Phthaloyl Peroxide. Organic Letters. 17: 4420-3. PMID 26333308 DOI: 10.1021/Acs.Orglett.5B02008  0.359
2015 Camelio AM, Johnson TC, Siegel D. Total Synthesis of Celastrol, Development of a Platform to Access Celastroid Natural Products. Journal of the American Chemical Society. 137: 11864-7. PMID 26331410 DOI: 10.1021/Jacs.5B06261  0.45
2015 Nelson AT, Camelio AM, Claussen KR, Cho J, Tremmel L, DiGiovanni J, Siegel D. Synthesis of oxygenated oleanolic and ursolic acid derivatives with anti-inflammatory properties. Bioorganic & Medicinal Chemistry Letters. 25: 4342-6. PMID 26259803 DOI: 10.1016/J.Bmcl.2015.07.029  0.38
2015 Camelio AM, Liang Y, Eliasen AM, Johnson TC, Yuan C, Schuppe AW, Houk KN, Siegel D. Computational and Experimental Studies of Phthaloyl Peroxide-Mediated Hydroxylation of Arenes Yield a More Reactive Derivative, 4,5-Dichlorophthaloyl Peroxide. The Journal of Organic Chemistry. 80: 8084-95. PMID 26200205 DOI: 10.1021/Acs.Joc.5B01079  0.405
2015 Chin MR, Zlotkowski K, Han M, Patel S, Eliasen AM, Axelrod A, Siegel D. Expedited access to vinaxanthone and chemically edited derivatives possessing neuronal regenerative effects through ynone coupling reactions. Acs Chemical Neuroscience. 6: 542-50. PMID 25615693 DOI: 10.1021/Cn500237Z  0.768
2014 Yuan C, Eliasen AM, Camelio AM, Siegel D. Preparation of phenols by phthaloyl peroxide-mediated oxidation of arenes Nature Protocols. 9: 2624-2629. PMID 25321407 DOI: 10.1038/Nprot.2014.175  0.435
2014 Eliasen AM, Thedford RP, Claussen KR, Yuan C, Siegel D. A protocol to generate phthaloyl peroxide in flow for the hydroxylation of arenes Organic Letters. 16: 3628-3631. PMID 24988535 DOI: 10.1021/Ol501497Y  0.309
2013 Zlotkowski K, Eliasen AM, Mitra A, Siegel D. Small-molecule mechanism of action studies in Caenorhabditis elegans. Chembiochem : a European Journal of Chemical Biology. 14: 2338-44. PMID 24123757 DOI: 10.1002/Cbic.201300399  0.328
2013 Yuan C, Liang Y, Hernandez T, Berriochoa A, Houk KN, Siegel D. Metal-free oxidation of aromatic carbon-hydrogen bonds through a reverse-rebound mechanism. Nature. 499: 192-6. PMID 23846658 DOI: 10.1038/Nature12284  0.378
2013 Yuan C, Chang CT, Siegel D. Syntheses of (+)-complanadine A and lycodine derivatives by regioselective [2 + 2 + 2] cycloadditions. The Journal of Organic Chemistry. 78: 5647-68. PMID 23635039 DOI: 10.1021/Jo400695C  0.429
2013 Zlotkowski K, Pierce-Shimomura J, Siegel D. Small-molecule-mediated axonal branching in Caenorhabditis elegans. Chembiochem : a European Journal of Chemical Biology. 14: 307-10. PMID 23362121 DOI: 10.1002/Cbic.201200712  0.307
2013 Axelrod A, Eliasen AM, Chin MR, Zlotkowski K, Siegel D. Syntheses of xanthofulvin and vinaxanthone, natural products enabling spinal cord regeneration Angewandte Chemie - International Edition. 52: 3421-3424. PMID 23086682 DOI: 10.1002/Anie.201205837  0.738
2012 Cheng X, Harzdorf N, Khaing Z, Kang D, Camelio AM, Shaw T, Schmidt CE, Siegel D. Neuronal growth promoting sesquiterpene-neolignans; syntheses and biological studies. Organic & Biomolecular Chemistry. 10: 383-93. PMID 22083452 DOI: 10.1039/C1Ob06363D  0.324
2012 Barton T, Siegel D. Investigation of an acrylate lynchpin approach toward the synthesis of stolonidiol Synthesis (Germany). 44: 2770-2778. DOI: 10.1055/S-0032-1316589  0.475
2011 Piasecki SK, Taylor CA, Detelich JF, Liu J, Zheng J, Komsoukaniants A, Siegel DR, Keatinge-Clay AT. Employing modular polyketide synthase ketoreductases as biocatalysts in the preparative chemoenzymatic syntheses of diketide chiral building blocks. Chemistry & Biology. 18: 1331-40. PMID 22035802 DOI: 10.1016/J.Chembiol.2011.07.021  0.432
2011 Vidal-Gadea A, Topper S, Young L, Crisp A, Kressin L, Elbel E, Maples T, Brauner M, Erbguth K, Axelrod A, Gottschalk A, Siegel D, Pierce-Shimomura JT. Caenorhabditis elegans selects distinct crawling and swimming gaits via dopamine and serotonin. Proceedings of the National Academy of Sciences of the United States of America. 108: 17504-9. PMID 21969584 DOI: 10.1073/Pnas.1108673108  0.737
2011 Camelio AM, Barton T, Guo F, Shaw T, Siegel D. Hydroxyl-directed cyclizations of 1,6-enynes Organic Letters. 13: 1517-1519. PMID 21314167 DOI: 10.1021/Ol200157X  0.387
2011 Camelio AM, Barton T, Guo F, Shaw T, Siegel D. Palladium-Catalyzed Enyne Cyclization towards Complex Cyclopentanes Synfacts. 2011: 631-631. DOI: 10.1055/S-0030-1260390  0.326
2011 Yuan C, Axelrod A, Varela M, Danysh L, Siegel D. Synthesis and reaction of phthaloyl peroxide derivatives, potential organocatalysts for the stereospecific dihydroxylation of alkenes Tetrahedron Letters. 52: 2540-2542. DOI: 10.1016/J.Tetlet.2011.03.005  0.788
2010 Yuan C, Chang CT, Axelrod A, Siegel D. Synthesis of (+)-complanadine A, an inducer of neurotrophic factor excretion. Journal of the American Chemical Society. 132: 5924-5. PMID 20387896 DOI: 10.1021/Ja101956X  0.771
2010 Cheng X, Harzdorf NL, Shaw T, Siegel D. Biomimetic syntheses of the neurotrophic natural products caryolanemagnolol and clovanemagnolol Organic Letters. 12: 1304-1307. PMID 20158263 DOI: 10.1021/Ol100214X  0.412
2010 Tsukano C, Siegel DR, Danishefsky SJ. Total syntheses of polycyclic polyp renylated acylphloroglucinols Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 68: 592-600. DOI: 10.5059/Yukigoseikyokaishi.68.592  0.564
2010 Yuan C, Chang C-, Axelrod A, Siegel D. Synthesis of (+)-Complanadine A Synfacts. 2010: 863-863. DOI: 10.1055/S-0030-1257770  0.784
2008 Sun C, Wang Q, Brubaker JD, Wright PM, Lerner CD, Noson K, Charest M, Siegel DR, Wang YM, Myers AG. A robust platform for the synthesis of new tetracycline antibiotics. Journal of the American Chemical Society. 130: 17913-27. PMID 19053822 DOI: 10.1021/Ja806629E  0.709
2008 Tsukano C, Siegel DR, Danishefsky SJ. Synthesis of Nemorosone and Clusianone Synfacts. 2008: 337-337. DOI: 10.1055/S-2008-1042888  0.576
2007 Tsukano C, Siegel DR, Danishefsky SJ. Differentiation of nonconventional "carbanions"-the total synthesis of nemorosone and clusianone. Angewandte Chemie (International Ed. in English). 46: 8840-4. PMID 17935090 DOI: 10.1002/Anie.200703886  0.533
2006 Liu H, Siegel DR, Danishefsky SJ. Studies directed toward the synthesis of terreulactone A: rapid construction of the A, B, C rings. Organic Letters. 8: 423-5. PMID 16435850 DOI: 10.1021/Ol052618P  0.6
2006 Siegel DR, Danishefsky SJ. Total synthesis of garsubellin A. Journal of the American Chemical Society. 128: 1048-9. PMID 16433500 DOI: 10.1021/Ja057418N  0.571
2006 Danishefsky S, Siegel D. Synthesis of Garsubellin A Synfacts. 2006: 0760-0760. DOI: 10.1055/S-2006-941930  0.453
2005 Charest MG, Siegel DR, Myers AG. Synthesis of (-)-tetracycline. Journal of the American Chemical Society. 127: 8292-3. PMID 15941256 DOI: 10.1021/Ja052151D  0.77
2005 Charest MG, Lerner CD, Brubaker JD, Siegel DR, Myers AG. A convergent enantioselective route to structurally diverse 6-deoxytetracycline antibiotics. Science (New York, N.Y.). 308: 395-8. PMID 15831754 DOI: 10.1126/Science.1109755  0.748
2001 Myers AG, Siegel DR, Buzard DJ, Charest MG. Synthesis of a broad array of highly functionalized, enantiomerically pure cyclohexanecarboxylic acid derivatives by microbial dihydroxylation of benzoic acid and subsequent oxidative and rearrangement reactions. Organic Letters. 3: 2923-6. PMID 11529791 DOI: 10.1021/Ol010151M  0.757
1999 Alper PB, Meyers C, Lerchner A, Siegel DR, Carreira EM. Facile, Novel Methodology for the Synthesis of Spiro Angewandte Chemie (International Ed. in English). 38: 3186-3189. PMID 10556897 DOI: 10.1002/(Sici)1521-3773(19991102)38:21<3186::Aid-Anie3186>3.3.Co;2-5  0.312
1999 Alper PB, Meyers C, Lerchner A, Siegel DR, Carreira EM. Facile, Novel Methodology for the Synthesis of Spiro[pyrrolidin‐3,3′‐oxindoles]: Catalyzed Ring Expansion Reactions of Cyclopropanes by Aldimines Angewandte Chemie. 38: 3186-3189. PMID 10556897 DOI: 10.1002/(Sici)1521-3773(19991102)38:21<3186::Aid-Anie3186>3.0.Co;2-E  0.453
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