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John D. Trzupek, Ph.D. - Publications

Affiliations: 
2006 Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
synthetic organic chemistry
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18 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Lee KL, Ambler CM, Anderson DR, Boscoe BP, Bree AG, Brodfuehrer JI, Chang JS, Choi C, Chung SW, Curran KJ, Day JE, Dehnhardt CM, Dower K, Drozda SE, Frisbie RK, ... ... Trzupek JD, et al. Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design. Journal of Medicinal Chemistry. PMID 28498658 DOI: 10.1021/Acs.Jmedchem.7B00231  0.314
2016 Knochel P, Hammann JM, Wright SW, Choi C, Chung S, Boscoe BP, Drozda SE, Mousseau JJ, Trzupek JD. Reverse Diastereocontrol in the Conjugate Addition of Cuprates Synfacts. 12: 80-80. DOI: 10.1055/S-0035-1561030  0.333
2015 Wright SW, Choi C, Chung S, Boscoe BP, Drozda SE, Mousseau JJ, Trzupek JD. Reversal of Diastereoselection in the Conjugate Addition of Cuprates to Unsaturated Lactams. Organic Letters. PMID 26485576 DOI: 10.1021/Acs.Orglett.5B02533  0.331
2010 Trzupek JD, Li C, Chan C, Crowley BM, Heimann AC, Danishefsky SJ. Lessons from the Total Synthesis of (±) Phalarine: Insights Into the Mechanism of the Pictet-Spengler Reaction. Pure and Applied Chemistry. Chimie Pure Et Appliquee. 82: 1735-1748. PMID 20711493 DOI: 10.1351/Pac-Con-09-11-14  0.692
2010 Trzupek JD, Lee D, Crowley BM, Marathias VM, Danishefsky SJ. Total synthesis of enantiopure phalarine via a stereospecific Pictet-Spengler reaction: traceless transfer of chirality from L-tryptophan. Journal of the American Chemical Society. 132: 8506-12. PMID 20509657 DOI: 10.1021/Ja1030968  0.66
2010 Shimamura H, Breazzano SP, Garfunkle J, Kimball FS, Trzupek JD, Boger DL. Total synthesis of complestatin: development of a Pd(0)-mediated indole annulation for macrocyclization. Journal of the American Chemical Society. 132: 7776-83. PMID 20469945 DOI: 10.1021/Ja102304P  0.684
2010 Trzupek JD, Li C, Chan C, Crowley BM, Heimann AC, Danishefsky SJ. Lessons from the total synthesis of (±)-phalarine: Insights into the mechanism of the Pictet-Spengler reaction Pure and Applied Chemistry. 82: 1735-1748. DOI: 10.1351/PAC-CON-09-11-14  0.615
2010 Danishefsky S, Trzupek J, Lee D, Crowley B, Marathias V. Synthesis of (-)-Phalarine Synfacts. 2010: 1099-1099. DOI: 10.1055/S-0030-1258625  0.665
2010 Garfunkle J, Kimball FS, Trzupek JD, Takizawa S, Shimamura H, Tomishima M, Boger DL. Synthesis of Chloropeptin II Synfacts. 2010: 263-263. DOI: 10.1055/S-0029-1219254  0.487
2009 Garfunkle J, Kimball FS, Trzupek JD, Takizawa S, Shimamura H, Tomishima M, Boger DL. Total synthesis of chloropeptin II (complestatin) and chloropeptin I. Journal of the American Chemical Society. 131: 16036-8. PMID 19839632 DOI: 10.1021/Ja907193B  0.625
2009 Kan C, Trzupek JD, Wu B, Wan Q, Chen G, Tan Z, Yuan Y, Danishefsky SJ. Toward homogeneous erythropoietin: chemical synthesis of the Ala1-Gly28 glycopeptide domain by "alanine" ligation. Journal of the American Chemical Society. 131: 5438-43. PMID 19334679 DOI: 10.1021/Ja808707W  0.381
2007 Jin W, Trzupek JD, Rayl TJ, Broward MA, Vielhauer GA, Weir SJ, Hwang I, Boger DL. A unique class of duocarmycin and CC-1065 analogues subject to reductive activation. Journal of the American Chemical Society. 129: 15391-7. PMID 18020335 DOI: 10.1021/Ja075398E  0.425
2007 Tichenor MS, MacMillan KS, Trzupek JD, Rayl TJ, Hwang I, Boger DL. Systematic exploration of the structural features of yatakemycin impacting DNA alkylation and biological activity. Journal of the American Chemical Society. 129: 10858-69. PMID 17691783 DOI: 10.1021/Ja072777Z  0.557
2006 Tichenor MS, Trzupek JD, Kastrinsky DB, Shiga F, Hwang I, Boger DL. Asymmetric total synthesis of (+)- and ent-(-)-yatakemycin and duocarmycin SA: evaluation of yatakemycin key partial structures and its unnatural enantiomer. Journal of the American Chemical Society. 128: 15683-96. PMID 17147378 DOI: 10.1021/Ja064228J  0.703
2006 Trzupek JD, Gottesfeld JM, Boger DL. Alkylation of duplex DNA in nucleosome core particles by duocarmycin SA and yatakemycin. Nature Chemical Biology. 2: 79-82. PMID 16415862 DOI: 10.1038/Nchembio761  0.505
2005 Toth JL, Trzupek JD, Flores LV, Kiakos K, Hartley JA, Pennington WT, Lee M. A novel achiral seco-amino-cyclopropylindoline (CI) analog of CC-1065 and the duocarmycins: design, synthesis and biological studies. Medicinal Chemistry (ShāRiqah (United Arab Emirates)). 1: 13-9. PMID 16789881 DOI: 10.2174/1573406053402523  0.403
2004 Kupchinsky S, Centioni S, Howard T, Trzupek J, Roller S, Carnahan V, Townes H, Purnell B, Price C, Handl H, Summerville K, Johnson K, Toth J, Hudson S, Kiakos K, et al. A novel class of achiral seco-analogs of CC-1065 and the duocarmycins: Design, synthesis, DNA binding, and anticancer properties Bioorganic and Medicinal Chemistry. 12: 6221-6236. PMID 15519165 DOI: 10.1016/J.Bmc.2004.08.051  0.345
2004 Parrish JP, Trzupek JD, Hughes TV, Hwang I, Boger DL. Synthesis and evaluation of N-aryl and N-alkenyl CBI derivatives. Bioorganic & Medicinal Chemistry. 12: 5845-56. PMID 15498660 DOI: 10.1016/J.Bmc.2004.08.032  0.522
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