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Anna L. Vagstad, Ph.D. - Publications

Affiliations: 
2012 Chemistry Biology Interface Johns Hopkins University, Baltimore, MD 
Area:
Organic and Bioorganic Chemistry
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24 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Hubrich F, Bösch NM, Chepkirui C, Morinaka BI, Rust M, Gugger M, Robinson SL, Vagstad AL, Piel J. Ribosomally derived lipopeptides containing distinct fatty acyl moieties. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35027450 DOI: 10.1073/pnas.2113120119  0.376
2020 Mordhorst S, Morinaka BI, Vagstad AL, Piel J. Posttranslationally Acting Arginases Provide a Ribosomal Route to Non-proteinogenic Ornithine Residues in Diverse Peptide Sequences. Angewandte Chemie (International Ed. in English). PMID 32780902 DOI: 10.1002/Anie.202008990  0.339
2020 Bösch NM, Borsa M, Greczmiel U, Morinaka BI, Gugger M, Oxenius A, Vagstad AL, Piel J. Landornamides: Antiviral Ornithine-Containing Ribosomal Peptides Discovered through Genome Mining. Angewandte Chemie (International Ed. in English). PMID 32163654 DOI: 10.1002/Anie.201916321  0.388
2018 Vagstad AL, Kuranaga T, Püntener S, Pattabiraman VR, Bode JW, Piel J. Introduction of D-Amino Acids in Minimalistic Peptide Substrates by an S-Adenosyl-L-Methionine Radical Epimerase. Angewandte Chemie (International Ed. in English). PMID 30521081 DOI: 10.1002/Anie.201809508  0.45
2018 Byer AS, Yang H, McDaniel EC, Kathiresan V, Impano S, Pagnier A, Watts H, Denler C, Vagstad A, Piel J, Duschene KS, Shepard EM, Shields TP, Scott LG, Lilla EA, et al. A paradigm shift for radical SAM reactions: The organometallic intermediate Ω is central to catalysis. Journal of the American Chemical Society. PMID 29954180 DOI: 10.1021/Jacs.8B04061  0.396
2018 Morinaka BI, Vagstad AL, Piel J. Radical S-Adenosylmethionine Peptide Epimerases: Detection of Activity and Characterization of d-Amino Acid Products. Methods in Enzymology. 604: 237-257. PMID 29779654 DOI: 10.1016/Bs.Mie.2018.01.033  0.43
2018 Morinaka BI, Lakis E, Verest M, Helf MJ, Scalvenzi T, Vagstad AL, Sims J, Sunagawa S, Gugger M, Piel J. Natural noncanonical protein splicing yields products with diverse β-amino acid residues. Science (New York, N.Y.). 359: 779-782. PMID 29449488 DOI: 10.1126/Science.Aao0157  0.476
2017 Barajas JF, Shakya G, Moreno G, Rivera H, Jackson DR, Topper CL, Vagstad AL, La Clair JJ, Townsend CA, Burkart MD, Tsai SC. Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases. Proceedings of the National Academy of Sciences of the United States of America. PMID 28484029 DOI: 10.1073/Pnas.1609001114  0.656
2016 Barajas JF, Finzel K, Valentic TR, Shakya G, Gamarra N, Martinez D, Meier JL, Vagstad AL, Newman AG, Townsend CA, Burkart MD, Tsai SC. Structural and Biochemical Analysis of Protein-Protein Interactions Between the Acyl-Carrier Protein and Product Template Domain. Angewandte Chemie (International Ed. in English). PMID 27653519 DOI: 10.1002/Anie.201605401  0.655
2015 Freeman MF, Vagstad AL, Piel J. Polytheonamide biosynthesis showcasing the metabolic potential of sponge-associated uncultivated 'Entotheonella' bacteria. Current Opinion in Chemical Biology. 31: 8-14. PMID 26625171 DOI: 10.1016/J.Cbpa.2015.11.002  0.604
2015 Huitt-Roehl CR, Hill EA, Adams MM, Vagstad AL, Li JW, Townsend CA. Starter Unit Flexibility for Engineered Product Synthesis by the Nonreducing Polyketide Synthase PksA. Acs Chemical Biology. 10: 1443-9. PMID 25714897 DOI: 10.1021/Acschembio.5B00005  0.771
2014 Morinaka BI, Vagstad AL, Helf MJ, Gugger M, Kegler C, Freeman MF, Bode HB, Piel J. Radical S-adenosyl methionine epimerases: regioselective introduction of diverse D-amino acid patterns into peptide natural products. Angewandte Chemie (International Ed. in English). 53: 8503-7. PMID 24943072 DOI: 10.1002/Anie.201400478  0.62
2014 Newman AG, Vagstad AL, Storm PA, Townsend CA. Systematic domain swaps of iterative, nonreducing polyketide synthases provide a mechanistic understanding and rationale for catalytic reprogramming. Journal of the American Chemical Society. 136: 7348-62. PMID 24815013 DOI: 10.1021/Ja5007299  0.677
2013 Bruegger J, Haushalter RW, Haushalter B, Vagstad AL, Vagstad A, Shakya G, Mih N, Townsend CA, Burkart MD, Tsai SC. Probing the selectivity and protein·protein interactions of a nonreducing fungal polyketide synthase using mechanism-based crosslinkers. Chemistry & Biology. 20: 1135-46. PMID 23993461 DOI: 10.1016/J.Chembiol.2013.07.012  0.546
2013 Vagstad AL, Newman AG, Storm PA, Belecki K, Crawford JM, Townsend CA. Combinatorial domain swaps provide insights into the rules of fungal polyketide synthase programming and the rational synthesis of non-native aromatic products. Angewandte Chemie (International Ed. in English). 52: 1718-21. PMID 23283670 DOI: 10.1002/Anie.201208550  0.747
2012 Vagstad AL, Hill EA, Labonte JW, Townsend CA. Characterization of a fungal thioesterase having Claisen cyclase and deacetylase activities in melanin biosynthesis. Chemistry & Biology. 19: 1525-34. PMID 23261597 DOI: 10.1016/j.chembiol.2012.10.002  0.752
2012 Newman AG, Vagstad AL, Belecki K, Scheerer JR, Townsend CA. Analysis of the cercosporin polyketide synthase CTB1 reveals a new fungal thioesterase function. Chemical Communications (Cambridge, England). 48: 11772-4. PMID 23108075 DOI: 10.1039/C2Cc36010A  0.643
2012 Vagstad AL, Bumpus SB, Belecki K, Kelleher NL, Townsend CA. Interrogation of global active site occupancy of a fungal iterative polyketide synthase reveals strategies for maintaining biosynthetic fidelity. Journal of the American Chemical Society. 134: 6865-77. PMID 22452347 DOI: 10.1021/Ja3016389  0.688
2012 Jensen K, Niederkrüger H, Zimmermann K, Vagstad AL, Moldenhauer J, Brendel N, Frank S, Pöplau P, Kohlhaas C, Townsend CA, Oldiges M, Hertweck C, Piel J. Polyketide proofreading by an acyltransferase-like enzyme. Chemistry & Biology. 19: 329-39. PMID 22444588 DOI: 10.1016/J.Chembiol.2012.01.005  0.632
2009 Crawford JM, Korman TP, Labonte JW, Vagstad AL, Hill EA, Kamari-Bidkorpeh O, Tsai SC, Townsend CA. Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization. Nature. 461: 1139-43. PMID 19847268 DOI: 10.1038/Nature08475  0.721
2008 Crawford JM, Vagstad AL, Ehrlich KC, Udwary DW, Townsend CA. Acyl-carrier protein-phosphopantetheinyltransferase partnerships in fungal fatty acid synthases. Chembiochem : a European Journal of Chemical Biology. 9: 1559-63. PMID 18551496 DOI: 10.1002/Cbic.200700659  0.735
2008 Crawford JM, Thomas PM, Scheerer JR, Vagstad AL, Kelleher NL, Townsend CA. Deconstruction of iterative multidomain polyketide synthase function. Science (New York, N.Y.). 320: 243-6. PMID 18403714 DOI: 10.1126/Science.1154711  0.745
2008 Crawford JM, Vagstad AL, Whitworth KP, Ehrlich KC, Townsend CA. Synthetic strategy of nonreducing iterative polyketide synthases and the origin of the classical "starter-unit effect". Chembiochem : a European Journal of Chemical Biology. 9: 1019-23. PMID 18338425 DOI: 10.1002/Cbic.200700702  0.736
2008 Crawford JM, Vagstad AL, Ehrlich KC, Townsend CA. Starter unit specificity directs genome mining of polyketide synthase pathways in fungi. Bioorganic Chemistry. 36: 16-22. PMID 18215412 DOI: 10.1016/J.Bioorg.2007.11.002  0.733
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