| Year |
Citation |
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| 2019 |
Yanagi KS, Wu Z, Amaya J, Chapkis N, Duffy AM, Hajdarovic KH, Held A, Mathur AD, Russo K, Ryan VH, Steinert BL, Whitt JP, Fallon JR, Fawzi NL, Lipscombe D, ... ... Hart AC, et al. Meta-analysis of Genetic Modifiers Reveals Candidate Dysregulated Pathways in Amyotrophic Lateral Sclerosis. Neuroscience. 396: A3-A20. PMID 30594291 DOI: 10.1016/j.neuroscience.2018.10.033 |
1 |
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| 2018 |
Baskoylu SN, Yersak J, O'Hern P, Grosser S, Simon J, Kim S, Schuch K, Dimitriadi M, Yanagi KS, Lins J, Hart AC. Single copy/knock-in models of ALS SOD1 in C. elegans suggest loss and gain of function have different contributions to cholinergic and glutamatergic neurodegeneration. Plos Genetics. 14: e1007682. PMID 30296255 DOI: 10.1371/journal.pgen.1007682 |
1 |
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| 2018 |
Nam YW, Baskoylu SN, Gazgalis D, Orfali R, Cui M, Hart AC, Zhang M. A V-to-F substitution in SK2 channels causes Ca hypersensitivity and improves locomotion in a C. elegans ALS model. Scientific Reports. 8: 10749. PMID 30013223 DOI: 10.1038/s41598-018-28783-2 |
1 |
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| 2018 |
Sorkaç A, DiIorio MA, O'Hern PJ, Baskoylu SN, Graham HK, Hart AC. LIN-12/Notch Regulates GABA Signaling at the Neuromuscular Junction. G3 (Bethesda, Md.). PMID 29950427 DOI: 10.1534/g3.118.200202 |
1 |
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| 2017 |
O'Hern PJ, do Carmo G Gonçalves I, Brecht J, López Soto EJ, Simon J, Chapkis N, Lipscombe D, Kye MJ, Hart AC. Decreased microRNA levels lead to deleterious increases in neuronal M2 muscarinic receptors in Spinal Muscular Atrophy models. Elife. 6. PMID 28463115 DOI: 10.7554/eLife.20752 |
1 |
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| 2017 |
Riessland M, Kaczmarek A, Schneider S, Swoboda KJ, Löhr H, Bradler C, Grysko V, Dimitriadi M, Hosseinibarkooie S, Torres-Benito L, Peters M, Upadhyay A, Biglari N, Kröber S, Hölker I, ... ... Hart AC, et al. Neurocalcin Delta Suppression Protects against Spinal Muscular Atrophy in Humans and across Species by Restoring Impaired Endocytosis. American Journal of Human Genetics. PMID 28132687 DOI: 10.1016/j.ajhg.2017.01.005 |
1 |
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| 2016 |
Sorkaç A, Alcantara IC, Hart AC. In Vivo Modelling of ATP1A3 G316S-Induced Ataxia in C. elegans Using CRISPR/Cas9-Mediated Homologous Recombination Reveals Dominant Loss of Function Defects. Plos One. 11: e0167963. PMID 27936181 DOI: 10.1371/journal.pone.0167963 |
1 |
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| 2016 |
Dimitriadi M, Derdowski A, Kalloo G, Maginnis MS, O'Hern P, Bliska B, Sorkaç A, Nguyen KC, Cook SJ, Poulogiannis G, Atwood WJ, Hall DH, Hart AC. Decreased function of survival motor neuron protein impairs endocytic pathways. Proceedings of the National Academy of Sciences of the United States of America. PMID 27402754 DOI: 10.1073/pnas.1600015113 |
1 |
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| 2016 |
Anderson EN, Corkins ME, Li JC, Singh K, Parsons S, Tucey TM, Sorkaç A, Huang H, Dimitriadi M, Sinclair DA, Hart AC. C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins. Mechanisms of Ageing and Development. PMID 26854551 DOI: 10.1016/j.mad.2016.01.004 |
1 |
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| 2014 |
Moroz N, Carmona JJ, Anderson E, Hart AC, Sinclair DA, Blackwell TK. Dietary restriction involves NAD⁺ -dependent mechanisms and a shift toward oxidative metabolism. Aging Cell. 13: 1075-85. PMID 25257342 DOI: 10.1111/acel.12273 |
1 |
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| 2014 |
Singh K, Ju JY, Walsh MB, DiIorio MA, Hart AC. Deep conservation of genes required for both Drosphila melanogaster and Caenorhabditis elegans sleep includes a role for dopaminergic signaling. Sleep. 37: 1439-51. PMID 25142568 DOI: 10.5665/sleep.3990 |
1 |
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| 2013 |
Sen A, Dimlich DN, Guruharsha KG, Kankel MW, Hori K, Yokokura T, Brachat S, Richardson D, Loureiro J, Sivasankaran R, Curtis D, Davidow LS, Rubin LL, Hart AC, Van Vactor D, et al. Genetic circuitry of Survival motor neuron, the gene underlying spinal muscular atrophy. Proceedings of the National Academy of Sciences of the United States of America. 110: E2371-80. PMID 23757500 DOI: 10.1073/pnas.1301738110 |
1 |
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| 2013 |
Kwon DY, Dimitriadi M, Terzic B, Cable C, Hart AC, Chitnis A, Fischbeck KH, Burnett BG. The E3 ubiquitin ligase mind bomb 1 ubiquitinates and promotes the degradation of survival of motor neuron protein. Molecular Biology of the Cell. 24: 1863-71. PMID 23615451 DOI: 10.1091/mbc.E13-01-0042 |
1 |
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| 2013 |
Dimitriadi M, Kye MJ, Kalloo G, Yersak JM, Sahin M, Hart AC. The neuroprotective drug riluzole acts via small conductance Ca2+-activated K+ channels to ameliorate defects in spinal muscular atrophy models. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 6557-62. PMID 23575853 DOI: 10.1523/JNEUROSCI.1536-12.2013 |
1 |
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| 2013 |
Singh K, Huang H, Hart AC. Do C. elegans sleep? A closer look. Sleep. 36: 307-8. PMID 23450901 DOI: 10.5665/sleep.2436 |
1 |
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| 2011 |
Liu-Yesucevitz L, Bassell GJ, Gitler AD, Hart AC, Klann E, Richter JD, Warren ST, Wolozin B. Local RNA translation at the synapse and in disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 16086-93. PMID 22072660 DOI: 10.1523/JNEUROSCI.4105-11.2011 |
1 |
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| 2011 |
Walker AK, Jacobs RL, Watts JL, Rottiers V, Jiang K, Finnegan DM, Shioda T, Hansen M, Yang F, Niebergall LJ, Vance DE, Tzoneva M, Hart AC, Näär AM. A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans. Cell. 147: 840-52. PMID 22035958 DOI: 10.1016/j.cell.2011.09.045 |
1 |
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| 2011 |
Singh K, Chao MY, Somers GA, Komatsu H, Corkins ME, Larkins-Ford J, Tucey T, Dionne HM, Walsh MB, Beaumont EK, Hart DP, Lockery SR, Hart AC. C. elegans Notch signaling regulates adult chemosensory response and larval molting quiescence. Current Biology : Cb. 21: 825-34. PMID 21549604 DOI: 10.1016/j.cub.2011.04.010 |
1 |
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| 2011 |
Hyde R, Corkins ME, Somers GA, Hart AC. PKC-1 acts with the ERK MAPK signaling pathway to regulate Caenorhabditis elegans mechanosensory response. Genes, Brain, and Behavior. 10: 286-98. PMID 21143768 DOI: 10.1111/j.1601-183X.2010.00667.x |
1 |
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| 2010 |
Dimitriadi M, Sleigh JN, Walker A, Chang HC, Sen A, Kalloo G, Harris J, Barsby T, Walsh MB, Satterlee JS, Li C, Van Vactor D, Artavanis-Tsakonas S, Hart AC. Conserved genes act as modifiers of invertebrate SMN loss of function defects. Plos Genetics. 6: e1001172. PMID 21124729 DOI: 10.1371/journal.pgen.1001172 |
1 |
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| 2010 |
Haspel G, O'Donovan MJ, Hart AC. Motoneurons dedicated to either forward or backward locomotion in the nematode Caenorhabditis elegans. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 11151-6. PMID 20720122 DOI: 10.1523/JNEUROSCI.2244-10.2010 |
1 |
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| 2010 |
Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, ... ... Hart AC, et al. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes & Development. 24: 1403-17. PMID 20595232 DOI: 10.1101/gad.1901210 |
1 |
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| 2010 |
Dimitriadi M, Hart AC. Neurodegenerative disorders: insights from the nematode Caenorhabditis elegans. Neurobiology of Disease. 40: 4-11. PMID 20493260 DOI: 10.1016/j.nbd.2010.05.012 |
1 |
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| 2009 |
Guo ZV, Hart AC, Ramanathan S. Optical interrogation of neural circuits in Caenorhabditis elegans. Nature Methods. 6: 891-6. PMID 19898486 DOI: 10.1038/nmeth.1397 |
1 |
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| 2009 |
Jeong H, Then F, Melia TJ, Mazzulli JR, Cui L, Savas JN, Voisine C, Paganetti P, Tanese N, Hart AC, Yamamoto A, Krainc D. Acetylation targets mutant huntingtin to autophagosomes for degradation. Cell. 137: 60-72. PMID 19345187 DOI: 10.1016/j.cell.2009.03.018 |
1 |
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| 2008 |
Chang HC, Dimlich DN, Yokokura T, Mukherjee A, Kankel MW, Sen A, Sridhar V, Fulga TA, Hart AC, Van Vactor D, Artavanis-Tsakonas S. Modeling spinal muscular atrophy in Drosophila. Plos One. 3: e3209. PMID 18791638 DOI: 10.1371/journal.pone.0003209 |
1 |
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| 2008 |
Komatsu H, Chao MY, Larkins-Ford J, Corkins ME, Somers GA, Tucey T, Dionne HM, White JQ, Wani K, Boxem M, Hart AC. OSM-11 facilitates LIN-12 Notch signaling during Caenorhabditis elegans vulval development. Plos Biology. 6: e196. PMID 18700817 DOI: 10.1371/journal.pbio.0060196 |
1 |
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| 2007 |
Varma H, Cheng R, Voisine C, Hart AC, Stockwell BR. Inhibitors of metabolism rescue cell death in Huntington's disease models. Proceedings of the National Academy of Sciences of the United States of America. 104: 14525-30. PMID 17726098 DOI: 10.1073/pnas.0704482104 |
1 |
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| 2007 |
Voisine C, Varma H, Walker N, Bates EA, Stockwell BR, Hart AC. Identification of potential therapeutic drugs for huntington's disease using Caenorhabditis elegans. Plos One. 2: e504. PMID 17551584 DOI: 10.1371/journal.pone.0000504 |
1 |
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| 2007 |
Ferkey DM, Hyde R, Haspel G, Dionne HM, Hess HA, Suzuki H, Schafer WR, Koelle MR, Hart AC. C. elegans G protein regulator RGS-3 controls sensitivity to sensory stimuli. Neuron. 53: 39-52. PMID 17196529 DOI: 10.1016/j.neuron.2006.11.015 |
1 |
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| 2007 |
Varma H, Voisine C, DeMarco CT, Cattaneo E, Lo DC, Hart AC, Stockwell BR. Selective inhibitors of death in mutant huntingtin cells. Nature Chemical Biology. 3: 99-100. PMID 17195849 DOI: 10.1038/nchembio852 |
1 |
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| 2007 |
Jia K, Hart AC, Levine B. Autophagy genes protect against disease caused by polyglutamine expansion proteins in Caenorhabditis elegans. Autophagy. 3: 21-5. PMID 17172799 |
1 |
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| 2006 |
Carre-Pierrat M, Baillie D, Johnsen R, Hyde R, Hart A, Granger L, Ségalat L. Characterization of the Caenorhabditis elegans G protein-coupled serotonin receptors. Invertebrate Neuroscience : In. 6: 189-205. PMID 17082916 DOI: 10.1007/s10158-006-0033-z |
1 |
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| 2006 |
Yang F, Vought BW, Satterlee JS, Walker AK, Jim Sun ZY, Watts JL, DeBeaumont R, Saito RM, Hyberts SG, Yang S, Macol C, Iyer L, Tjian R, van den Heuvel S, Hart AC, et al. An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Nature. 442: 700-4. PMID 16799563 DOI: 10.1038/nature04942 |
1 |
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| 2006 |
Bates EA, Victor M, Jones AK, Shi Y, Hart AC. Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 2830-8. PMID 16525063 DOI: 10.1523/JNEUROSCI.3344-05.2006 |
1 |
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| 2005 |
Chao MY, Larkins-Ford J, Tucey TM, Hart AC. lin-12 Notch functions in the adult nervous system of C. elegans. Bmc Neuroscience. 6: 45. PMID 16011804 DOI: 10.1186/1471-2202-6-45 |
1 |
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| 2004 |
Chao MY, Komatsu H, Fukuto HS, Dionne HM, Hart AC. Feeding status and serotonin rapidly and reversibly modulate a Caenorhabditis elegans chemosensory circuit. Proceedings of the National Academy of Sciences of the United States of America. 101: 15512-7. PMID 15492222 DOI: 10.1073/pnas.0403369101 |
1 |
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| 2004 |
Voisine C, Hart AC. Caenorhabditis elegans as a model system for triplet repeat diseases. Methods in Molecular Biology (Clifton, N.J.). 277: 141-60. PMID 15201454 DOI: 10.1385/1-59259-804-8:141 |
1 |
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| 2004 |
Fukuto HS, Ferkey DM, Apicella AJ, Lans H, Sharmeen T, Chen W, Lefkowitz RJ, Jansen G, Schafer WR, Hart AC. G protein-coupled receptor kinase function is essential for chemosensation in C. elegans. Neuron. 42: 581-93. PMID 15157420 DOI: 10.1016/S0896-6273(04)00252-1 |
1 |
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| 2003 |
Chao MY, Hart AC. Sensory biology: how the nose knows. Current Biology : Cb. 13: R226-8. PMID 12646147 DOI: 10.1016/S0960-9822(03)00156-8 |
1 |
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| 2002 |
Faber PW, Voisine C, King DC, Bates EA, Hart AC. Glutamine/proline-rich PQE-1 proteins protect Caenorhabditis elegans neurons from huntingtin polyglutamine neurotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 99: 17131-6. PMID 12486229 DOI: 10.1073/pnas.262544899 |
1 |
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| 2002 |
Nathoo AN, Moeller RA, Westlund BA, Hart AC. More neuropeptides in C elegans Genome Biology. 3: 0010. |
1 |
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| 2001 |
Nathoo AN, Moeller RA, Westlund BA, Hart AC. Identification of neuropeptide-like protein gene families in Caenorhabditiselegans and other species. Proceedings of the National Academy of Sciences of the United States of America. 98: 14000-5. PMID 11717458 DOI: 10.1073/pnas.241231298 |
1 |
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| 1999 |
Li C, Nelson LS, Kim K, Nathoo A, Hart AC. Neuropeptide gene families in the nematode Caenorhabditis elegans. Annals of the New York Academy of Sciences. 897: 239-52. PMID 10676452 |
1 |
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| 1999 |
Hart AC, Kass J, Shapiro JE, Kaplan JM. Distinct signaling pathways mediate touch and osmosensory responses in a polymodal sensory neuron. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 1952-8. PMID 10066248 |
1 |
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| 1999 |
Faber PW, Alter JR, MacDonald ME, Hart AC. Polyglutamine-mediated dysfunction and apoptotic death of a Caenorhabditis elegans sensory neuron. Proceedings of the National Academy of Sciences of the United States of America. 96: 179-84. PMID 9874792 DOI: 10.1073/pnas.96.1.179 |
1 |
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| 1999 |
Hart AC. Chapter 3.3.6 Forward genetic approaches in the analysis of Caenorhabditis elegans Techniques in the Behavioral and Neural Sciences. 13: 569-584. DOI: 10.1016/S0921-0709(99)80045-5 |
1 |
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| 1998 |
Serra-Pagès C, Medley QG, Tang M, Hart A, Streuli M. Liptins, a family of LAR transmembrane protein-tyrosine phosphatase- interacting proteins Journal of Biological Chemistry. 273: 15611-15620. PMID 9624153 DOI: 10.1074/jbc.273.25.15611 |
1 |
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| 1998 |
Berger AJ, Hart AC, Kaplan JM. G alphas-induced neurodegeneration in Caenorhabditis elegans. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 2871-80. PMID 9526004 |
1 |
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| 1995 |
Hart AC, Sims S, Kaplan JM. Synaptic code for sensory modalities revealed by C. elegans GLR-1 glutamate receptor. Nature. 378: 82-5. PMID 7477294 DOI: 10.1038/378082a0 |
1 |
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| 1993 |
Hart AC, Harrison SD, Van Vactor DL, Rubin GM, Zipursky SL. The interaction of bride of sevenless with sevenless is conserved between Drosophila virilis and Drosophila melanogaster. Proceedings of the National Academy of Sciences of the United States of America. 90: 5047-51. PMID 8506350 |
0.68 |
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| 1993 |
Hart AC, Krämer H, Zipursky SL. Extracellular domain of the boss transmembrane ligand acts as an antagonist of the sev receptor. Nature. 361: 732-6. PMID 7680109 DOI: 10.1038/361732a0 |
1 |
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| 1992 |
Zipursky SL, Krämer H, Cagan R, Hart A, Vactor DV. Induction of the R7 neuron in the Drosophila compound eye: the bride of sevenless and sevenless interaction. Cold Spring Harbor Symposia On Quantitative Biology. 57: 381-9. PMID 1339673 |
1 |
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| 1992 |
Cagan RL, Krämer H, Hart AC, Zipursky SL. The bride of sevenless and sevenless interaction: internalization of a transmembrane ligand. Cell. 69: 393-9. PMID 1316239 DOI: 10.1016/0092-8674(92)90442-F |
1 |
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| 1990 |
Hart AC, Krämer H, Van Vactor DL, Paidhungat M, Zipursky SL. Induction of cell fate in the Drosophila retina: the bride of sevenless protein is predicted to contain a large extracellular domain and seven transmembrane segments. Genes & Development. 4: 1835-47. PMID 2276620 |
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