Anne C. Hart - Publications

Affiliations: 
Harvard Medical School, Boston, MA, United States 
 Neuroscience Brown University, Providence, RI 

55 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Yanagi KS, Wu Z, Amaya J, Chapkis N, Duffy AM, Hajdarovic KH, Held A, Mathur AD, Russo K, Ryan VH, Steinert BL, Whitt JP, Fallon JR, Fawzi NL, Lipscombe D, ... ... Hart AC, et al. Meta-analysis of Genetic Modifiers Reveals Candidate Dysregulated Pathways in Amyotrophic Lateral Sclerosis. Neuroscience. 396: A3-A20. PMID 30594291 DOI: 10.1016/j.neuroscience.2018.10.033  1
2018 Baskoylu SN, Yersak J, O'Hern P, Grosser S, Simon J, Kim S, Schuch K, Dimitriadi M, Yanagi KS, Lins J, Hart AC. Single copy/knock-in models of ALS SOD1 in C. elegans suggest loss and gain of function have different contributions to cholinergic and glutamatergic neurodegeneration. Plos Genetics. 14: e1007682. PMID 30296255 DOI: 10.1371/journal.pgen.1007682  1
2018 Nam YW, Baskoylu SN, Gazgalis D, Orfali R, Cui M, Hart AC, Zhang M. A V-to-F substitution in SK2 channels causes Ca hypersensitivity and improves locomotion in a C. elegans ALS model. Scientific Reports. 8: 10749. PMID 30013223 DOI: 10.1038/s41598-018-28783-2  1
2018 Sorkaç A, DiIorio MA, O'Hern PJ, Baskoylu SN, Graham HK, Hart AC. LIN-12/Notch Regulates GABA Signaling at the Neuromuscular Junction. G3 (Bethesda, Md.). PMID 29950427 DOI: 10.1534/g3.118.200202  1
2017 O'Hern PJ, do Carmo G Gonçalves I, Brecht J, López Soto EJ, Simon J, Chapkis N, Lipscombe D, Kye MJ, Hart AC. Decreased microRNA levels lead to deleterious increases in neuronal M2 muscarinic receptors in Spinal Muscular Atrophy models. Elife. 6. PMID 28463115 DOI: 10.7554/eLife.20752  1
2017 Riessland M, Kaczmarek A, Schneider S, Swoboda KJ, Löhr H, Bradler C, Grysko V, Dimitriadi M, Hosseinibarkooie S, Torres-Benito L, Peters M, Upadhyay A, Biglari N, Kröber S, Hölker I, ... ... Hart AC, et al. Neurocalcin Delta Suppression Protects against Spinal Muscular Atrophy in Humans and across Species by Restoring Impaired Endocytosis. American Journal of Human Genetics. PMID 28132687 DOI: 10.1016/j.ajhg.2017.01.005  1
2016 Sorkaç A, Alcantara IC, Hart AC. In Vivo Modelling of ATP1A3 G316S-Induced Ataxia in C. elegans Using CRISPR/Cas9-Mediated Homologous Recombination Reveals Dominant Loss of Function Defects. Plos One. 11: e0167963. PMID 27936181 DOI: 10.1371/journal.pone.0167963  1
2016 Dimitriadi M, Derdowski A, Kalloo G, Maginnis MS, O'Hern P, Bliska B, Sorkaç A, Nguyen KC, Cook SJ, Poulogiannis G, Atwood WJ, Hall DH, Hart AC. Decreased function of survival motor neuron protein impairs endocytic pathways. Proceedings of the National Academy of Sciences of the United States of America. PMID 27402754 DOI: 10.1073/pnas.1600015113  1
2016 Anderson EN, Corkins ME, Li JC, Singh K, Parsons S, Tucey TM, Sorkaç A, Huang H, Dimitriadi M, Sinclair DA, Hart AC. C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins. Mechanisms of Ageing and Development. PMID 26854551 DOI: 10.1016/j.mad.2016.01.004  1
2014 Moroz N, Carmona JJ, Anderson E, Hart AC, Sinclair DA, Blackwell TK. Dietary restriction involves NAD⁺ -dependent mechanisms and a shift toward oxidative metabolism. Aging Cell. 13: 1075-85. PMID 25257342 DOI: 10.1111/acel.12273  1
2014 Singh K, Ju JY, Walsh MB, DiIorio MA, Hart AC. Deep conservation of genes required for both Drosphila melanogaster and Caenorhabditis elegans sleep includes a role for dopaminergic signaling. Sleep. 37: 1439-51. PMID 25142568 DOI: 10.5665/sleep.3990  1
2013 Sen A, Dimlich DN, Guruharsha KG, Kankel MW, Hori K, Yokokura T, Brachat S, Richardson D, Loureiro J, Sivasankaran R, Curtis D, Davidow LS, Rubin LL, Hart AC, Van Vactor D, et al. Genetic circuitry of Survival motor neuron, the gene underlying spinal muscular atrophy. Proceedings of the National Academy of Sciences of the United States of America. 110: E2371-80. PMID 23757500 DOI: 10.1073/pnas.1301738110  1
2013 Kwon DY, Dimitriadi M, Terzic B, Cable C, Hart AC, Chitnis A, Fischbeck KH, Burnett BG. The E3 ubiquitin ligase mind bomb 1 ubiquitinates and promotes the degradation of survival of motor neuron protein. Molecular Biology of the Cell. 24: 1863-71. PMID 23615451 DOI: 10.1091/mbc.E13-01-0042  1
2013 Dimitriadi M, Kye MJ, Kalloo G, Yersak JM, Sahin M, Hart AC. The neuroprotective drug riluzole acts via small conductance Ca2+-activated K+ channels to ameliorate defects in spinal muscular atrophy models. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 6557-62. PMID 23575853 DOI: 10.1523/JNEUROSCI.1536-12.2013  1
2013 Singh K, Huang H, Hart AC. Do C. elegans sleep? A closer look. Sleep. 36: 307-8. PMID 23450901 DOI: 10.5665/sleep.2436  1
2011 Liu-Yesucevitz L, Bassell GJ, Gitler AD, Hart AC, Klann E, Richter JD, Warren ST, Wolozin B. Local RNA translation at the synapse and in disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 16086-93. PMID 22072660 DOI: 10.1523/JNEUROSCI.4105-11.2011  1
2011 Walker AK, Jacobs RL, Watts JL, Rottiers V, Jiang K, Finnegan DM, Shioda T, Hansen M, Yang F, Niebergall LJ, Vance DE, Tzoneva M, Hart AC, Näär AM. A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans. Cell. 147: 840-52. PMID 22035958 DOI: 10.1016/j.cell.2011.09.045  1
2011 Singh K, Chao MY, Somers GA, Komatsu H, Corkins ME, Larkins-Ford J, Tucey T, Dionne HM, Walsh MB, Beaumont EK, Hart DP, Lockery SR, Hart AC. C. elegans Notch signaling regulates adult chemosensory response and larval molting quiescence. Current Biology : Cb. 21: 825-34. PMID 21549604 DOI: 10.1016/j.cub.2011.04.010  1
2011 Hyde R, Corkins ME, Somers GA, Hart AC. PKC-1 acts with the ERK MAPK signaling pathway to regulate Caenorhabditis elegans mechanosensory response. Genes, Brain, and Behavior. 10: 286-98. PMID 21143768 DOI: 10.1111/j.1601-183X.2010.00667.x  1
2010 Dimitriadi M, Sleigh JN, Walker A, Chang HC, Sen A, Kalloo G, Harris J, Barsby T, Walsh MB, Satterlee JS, Li C, Van Vactor D, Artavanis-Tsakonas S, Hart AC. Conserved genes act as modifiers of invertebrate SMN loss of function defects. Plos Genetics. 6: e1001172. PMID 21124729 DOI: 10.1371/journal.pgen.1001172  1
2010 Haspel G, O'Donovan MJ, Hart AC. Motoneurons dedicated to either forward or backward locomotion in the nematode Caenorhabditis elegans. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 11151-6. PMID 20720122 DOI: 10.1523/JNEUROSCI.2244-10.2010  1
2010 Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, ... ... Hart AC, et al. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes & Development. 24: 1403-17. PMID 20595232 DOI: 10.1101/gad.1901210  1
2010 Dimitriadi M, Hart AC. Neurodegenerative disorders: insights from the nematode Caenorhabditis elegans. Neurobiology of Disease. 40: 4-11. PMID 20493260 DOI: 10.1016/j.nbd.2010.05.012  1
2009 Guo ZV, Hart AC, Ramanathan S. Optical interrogation of neural circuits in Caenorhabditis elegans. Nature Methods. 6: 891-6. PMID 19898486 DOI: 10.1038/nmeth.1397  1
2009 Jeong H, Then F, Melia TJ, Mazzulli JR, Cui L, Savas JN, Voisine C, Paganetti P, Tanese N, Hart AC, Yamamoto A, Krainc D. Acetylation targets mutant huntingtin to autophagosomes for degradation. Cell. 137: 60-72. PMID 19345187 DOI: 10.1016/j.cell.2009.03.018  1
2008 Chang HC, Dimlich DN, Yokokura T, Mukherjee A, Kankel MW, Sen A, Sridhar V, Fulga TA, Hart AC, Van Vactor D, Artavanis-Tsakonas S. Modeling spinal muscular atrophy in Drosophila. Plos One. 3: e3209. PMID 18791638 DOI: 10.1371/journal.pone.0003209  1
2008 Komatsu H, Chao MY, Larkins-Ford J, Corkins ME, Somers GA, Tucey T, Dionne HM, White JQ, Wani K, Boxem M, Hart AC. OSM-11 facilitates LIN-12 Notch signaling during Caenorhabditis elegans vulval development. Plos Biology. 6: e196. PMID 18700817 DOI: 10.1371/journal.pbio.0060196  1
2007 Varma H, Cheng R, Voisine C, Hart AC, Stockwell BR. Inhibitors of metabolism rescue cell death in Huntington's disease models. Proceedings of the National Academy of Sciences of the United States of America. 104: 14525-30. PMID 17726098 DOI: 10.1073/pnas.0704482104  1
2007 Voisine C, Varma H, Walker N, Bates EA, Stockwell BR, Hart AC. Identification of potential therapeutic drugs for huntington's disease using Caenorhabditis elegans. Plos One. 2: e504. PMID 17551584 DOI: 10.1371/journal.pone.0000504  1
2007 Ferkey DM, Hyde R, Haspel G, Dionne HM, Hess HA, Suzuki H, Schafer WR, Koelle MR, Hart AC. C. elegans G protein regulator RGS-3 controls sensitivity to sensory stimuli. Neuron. 53: 39-52. PMID 17196529 DOI: 10.1016/j.neuron.2006.11.015  1
2007 Varma H, Voisine C, DeMarco CT, Cattaneo E, Lo DC, Hart AC, Stockwell BR. Selective inhibitors of death in mutant huntingtin cells. Nature Chemical Biology. 3: 99-100. PMID 17195849 DOI: 10.1038/nchembio852  1
2007 Jia K, Hart AC, Levine B. Autophagy genes protect against disease caused by polyglutamine expansion proteins in Caenorhabditis elegans. Autophagy. 3: 21-5. PMID 17172799  1
2006 Carre-Pierrat M, Baillie D, Johnsen R, Hyde R, Hart A, Granger L, Ségalat L. Characterization of the Caenorhabditis elegans G protein-coupled serotonin receptors. Invertebrate Neuroscience : In. 6: 189-205. PMID 17082916 DOI: 10.1007/s10158-006-0033-z  1
2006 Yang F, Vought BW, Satterlee JS, Walker AK, Jim Sun ZY, Watts JL, DeBeaumont R, Saito RM, Hyberts SG, Yang S, Macol C, Iyer L, Tjian R, van den Heuvel S, Hart AC, et al. An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Nature. 442: 700-4. PMID 16799563 DOI: 10.1038/nature04942  1
2006 Bates EA, Victor M, Jones AK, Shi Y, Hart AC. Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 2830-8. PMID 16525063 DOI: 10.1523/JNEUROSCI.3344-05.2006  1
2005 Chao MY, Larkins-Ford J, Tucey TM, Hart AC. lin-12 Notch functions in the adult nervous system of C. elegans. Bmc Neuroscience. 6: 45. PMID 16011804 DOI: 10.1186/1471-2202-6-45  1
2004 Chao MY, Komatsu H, Fukuto HS, Dionne HM, Hart AC. Feeding status and serotonin rapidly and reversibly modulate a Caenorhabditis elegans chemosensory circuit. Proceedings of the National Academy of Sciences of the United States of America. 101: 15512-7. PMID 15492222 DOI: 10.1073/pnas.0403369101  1
2004 Voisine C, Hart AC. Caenorhabditis elegans as a model system for triplet repeat diseases. Methods in Molecular Biology (Clifton, N.J.). 277: 141-60. PMID 15201454 DOI: 10.1385/1-59259-804-8:141  1
2004 Fukuto HS, Ferkey DM, Apicella AJ, Lans H, Sharmeen T, Chen W, Lefkowitz RJ, Jansen G, Schafer WR, Hart AC. G protein-coupled receptor kinase function is essential for chemosensation in C. elegans. Neuron. 42: 581-93. PMID 15157420 DOI: 10.1016/S0896-6273(04)00252-1  1
2003 Chao MY, Hart AC. Sensory biology: how the nose knows. Current Biology : Cb. 13: R226-8. PMID 12646147 DOI: 10.1016/S0960-9822(03)00156-8  1
2002 Faber PW, Voisine C, King DC, Bates EA, Hart AC. Glutamine/proline-rich PQE-1 proteins protect Caenorhabditis elegans neurons from huntingtin polyglutamine neurotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 99: 17131-6. PMID 12486229 DOI: 10.1073/pnas.262544899  1
2002 Nathoo AN, Moeller RA, Westlund BA, Hart AC. More neuropeptides in C elegans Genome Biology. 3: 0010.  1
2001 Nathoo AN, Moeller RA, Westlund BA, Hart AC. Identification of neuropeptide-like protein gene families in Caenorhabditiselegans and other species. Proceedings of the National Academy of Sciences of the United States of America. 98: 14000-5. PMID 11717458 DOI: 10.1073/pnas.241231298  1
1999 Li C, Nelson LS, Kim K, Nathoo A, Hart AC. Neuropeptide gene families in the nematode Caenorhabditis elegans. Annals of the New York Academy of Sciences. 897: 239-52. PMID 10676452  1
1999 Hart AC, Kass J, Shapiro JE, Kaplan JM. Distinct signaling pathways mediate touch and osmosensory responses in a polymodal sensory neuron. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 1952-8. PMID 10066248  1
1999 Faber PW, Alter JR, MacDonald ME, Hart AC. Polyglutamine-mediated dysfunction and apoptotic death of a Caenorhabditis elegans sensory neuron. Proceedings of the National Academy of Sciences of the United States of America. 96: 179-84. PMID 9874792 DOI: 10.1073/pnas.96.1.179  1
1999 Hart AC. Chapter 3.3.6 Forward genetic approaches in the analysis of Caenorhabditis elegans Techniques in the Behavioral and Neural Sciences. 13: 569-584. DOI: 10.1016/S0921-0709(99)80045-5  1
1998 Serra-Pagès C, Medley QG, Tang M, Hart A, Streuli M. Liptins, a family of LAR transmembrane protein-tyrosine phosphatase- interacting proteins Journal of Biological Chemistry. 273: 15611-15620. PMID 9624153 DOI: 10.1074/jbc.273.25.15611  1
1998 Berger AJ, Hart AC, Kaplan JM. G alphas-induced neurodegeneration in Caenorhabditis elegans. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 2871-80. PMID 9526004  1
1995 Hart AC, Sims S, Kaplan JM. Synaptic code for sensory modalities revealed by C. elegans GLR-1 glutamate receptor. Nature. 378: 82-5. PMID 7477294 DOI: 10.1038/378082a0  1
1993 Hart AC, Harrison SD, Van Vactor DL, Rubin GM, Zipursky SL. The interaction of bride of sevenless with sevenless is conserved between Drosophila virilis and Drosophila melanogaster. Proceedings of the National Academy of Sciences of the United States of America. 90: 5047-51. PMID 8506350  0.68
1993 Hart AC, Krämer H, Zipursky SL. Extracellular domain of the boss transmembrane ligand acts as an antagonist of the sev receptor. Nature. 361: 732-6. PMID 7680109 DOI: 10.1038/361732a0  1
1992 Zipursky SL, Krämer H, Cagan R, Hart A, Vactor DV. Induction of the R7 neuron in the Drosophila compound eye: the bride of sevenless and sevenless interaction. Cold Spring Harbor Symposia On Quantitative Biology. 57: 381-9. PMID 1339673  1
1992 Cagan RL, Krämer H, Hart AC, Zipursky SL. The bride of sevenless and sevenless interaction: internalization of a transmembrane ligand. Cell. 69: 393-9. PMID 1316239 DOI: 10.1016/0092-8674(92)90442-F  1
1990 Hart AC, Krämer H, Van Vactor DL, Paidhungat M, Zipursky SL. Induction of cell fate in the Drosophila retina: the bride of sevenless protein is predicted to contain a large extracellular domain and seven transmembrane segments. Genes & Development. 4: 1835-47. PMID 2276620  1
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